Ernesto J V Crescenti, Vanina A Medina, Lorena A Sambuco, Graciela A Cremaschi, Ana M Genaro, Graciela P Cricco, Gabriela A Martín, Eduardo Valli, Diego J Martinel Lamas, Juan C Perazzo, Elena S Rivera, Rosa M Bergoc
Scleroderma, sclerosis of the skin, is a severe autoimmune disease refractant to all kind of treatments. To study the in vivo effects of a combination of three oligoelements selenium (Se), zinc (Zn), and manganese (Mn) plus Lachesis muta venom (O-LM) on the bleomycin (BLM)-induced scleroderma mouse experimental model. C3H mice were randomly divided into four groups: control (phosphate-buffered saline (PBS)), O-LM, BLM, and BLM + O-LM. All administrations were performed subcutaneously into the back of mice...
February 2014: Biological Trace Element Research