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Cyril Burin-des-Roziers, Pierre-Raphael Rothschild, Valérie Layet, Jian-Min Chen, Tiffany Ghiotti, Céline Leroux, Frans P M Cremers, Antoine P Brézin, Sophie Valleix
Wagner disease is a rare non-syndromic autosomal dominant vitreoretinopathy, associated with splice mutations specifically targeting VCAN exon 8. We report the extensive genetic analysis of two Wagner probands, previously found negative for disease-associated splice mutations. Next-generation sequencing, quantitative real-time PCR, and long-range PCR, identified two deletions (3.4 kb and 10.5 kb) removing at least one exon-intron boundary of exon 8, and both correlating with an imbalance of VCAN mRNA isoforms...
September 26, 2016: Human Mutation
Ahmad Manasrah, Nathan Crane, Rasim Guldiken, Kyle B Reed
Temperature perception is a highly nonlinear phenomenon with faster rates of change being perceived at much lower thresholds than slower rates. This paper presents a method that takes advantage of this nonlinear characteristic to generate a perception of continuous cooling even though the average temperature is not changing. The method uses multiple thermal actuators so that a few are cooling quickly while the rest of the actuators are heating slowly. The slowly-heating actuators are below the perceptual threshold temperature change and hence are not perceived, while the quickly-cooling actuators are above the perceptual temperature change, hence are perceived...
June 8, 2016: IEEE Transactions on Haptics
Chung Whan Lee, Seo-Jung Han, Scott C Virgil, Brian M Stoltz
An improved method for the asymetric alkylation of 3-bromooxindoles with α-arylated malonate esters is described. The asymmetric alkylation demonstrated was achieved up to 70% ee utilizing a copper(II) bis(phosphine) complex.
June 3, 2015: Tetrahedron
Rania Djemal, Habib Khoudi
Over the last decade, APETALA2/Ethylene Responsive Factor (AP2/ERF) proteins have become the subject of intensive research activity due to their involvement in a variety of biological processes. This research led to the identification of AP2/ERF genes in many species; however, little is known about these genes in durum wheat, one of the most important cereal crops in the world. In this study, a new member of the AP2/ERF transcription factor family, designated TdSHN1, was isolated from durum wheat using thermal asymetric interlaced PCR (TAIL-PCR) method...
November 2015: Protoplasma
Michael R Rowland, Neli P Ragina, Joy Sarkar, Catherine F T Uyehara, Anthony J Senagore
BACKGROUND: Hemorrhagic shock leads to a complex cascade of metabolic and hormonal processes that may result in hypoperfusion, end organ damage, and death even when blood pressure is restored. Studies have shown that morbidity and mortality could be attributable to a diminished availability of endothelial-derived nitric oxide (eNO). It is unclear whether adequate levels of citrulline (CIT) and arginine (ARG)--the precursors of eNO synthesis--are available to sustain the eNO needed to maintain adequate perfusion in severe shock...
October 2014: Surgery
Ivana Basta, Ana Nikolić, Slobodan Apostolski, Slobodan Lavrnić, Tatjana Stosić-Opinćal, Sandra Banjalić, Sladana Knezević-Apostolski, Tihomir V Ilić, Ivan Marjanović, Milena Milićev, Dragana Lavrnić
BACKGROUND/AIM: Multifocal motor neuropathy (MMN) is an immune-mediated disorder characterised by slowly progressive asymetrical weakness of limbs without sensory loss. The objective of this study was to investigate the involvement of brachial plexus using combined cervical magnetic stimulation and magnetic resonance imaging (MRI) of plexus brachialis in patients with MMN. We payed special attention to the nerve roots forming nerves inervating weak muscles, but without detectable conduction block (CB) using conventional nerve conduction studies...
August 2014: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Grégory Genta-Jouve, Olivier P Thomas
The marine sponge Haliclona fulva (previously described as Reniera fulva) is widespread in the Mediterranean Sea. The chemical study of the sponge led to the isolation and identification of a new compound: 3-epi-cladocroic acid (1) alongside the previously reported cladocroic acid (2) and some other known compounds previously isolated. The structure was fully determined on the basis of extensive analysis by 1D and 2D NMR, as well as GC-MS/MS. The absolute configuration was determined by comparison of the experimental electronic circular dichroism (ECD) spectra with theoretically calculated spectra; these results may be extended to other asymetric cyclopropane carboxylic acids...
2013: Metabolites
Fa-Chun Hu, Sheng-Wei Wang, Yun Chi, Neil Robertson, Tracy Hewat, Yue Hu, Shih-Hung Liu, Pi-Tai Chou, Po-Fan Yang, Hao-Wu Lin
To supplement our study on thiocyanate-free ruthenium sensitizers (TFRS) for dye-sensitized solar cells (DSSCs), which belong to a class of Ru(II)-based complexes coordinated by a single 4,4'-dicarboxylic acid-2,2'-bipyridine and two symmetrically arranged functionalized trans-azolate chelates, we carefully isolated and characterized the second and less-abundant stereoisomer, in which the two pyridyl azolate ancillaries are asymetrically cis-arranged to each other. Two distinctive ancillaries, namely: 5-[4-(5-hexyl-2-thienyl)-2-pyridinyl]-3-trifluoromethyl pyrazole and 5-(6-tert-butyl-1-isoquinolinyl)-3-trifluoromethyl pyrazole, were employed in this study, giving a total of four sensitizers, that is, thienyl substituted TFRS-2 a and 2 b, and isoquinolinyl substituted TFRS-52 a and 52 b, in which the suffix b indicates the cis-stereoisomers...
April 14, 2014: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Thomas Forst, Ernestos Anastassiadis, Stephan Diessel, Andrea Löffler, Andreas Pfützner
BACKGROUND: The goal of this study was to investigate the effects of linagliptin compared with glimepiride on alpha and beta cell function and several vascular biomarkers after a standardized test meal. METHODS: Thirty-nine patients on metformin alone (age, 64 ± 7 years; duration of type 2 diabetes mellitus, 7.8 ± 4.5years, 27 male, 12 female; HbA1c , 57.2 ± 6.9 mmol/mol; mean ± SD) were randomized to receive linagliptin 5 mg (n = 19) or glimepiride (n = 20) for a study duration of 12 weeks...
October 2014: Diabetes/metabolism Research and Reviews
Z Lest'anová, Z Bacová, T Havránek, J Bakos
Brain development is determined by neuronal differentiation including changes of cell polarity and asymetric growth of neuronal processes. Although, there are many unkown factors contributing to changes of lenght of neuronal cones, mounting experimental and review papers focus on changes of growth conus and role of axonal transport. In particular, mechanisms of actin/microtubule polymerisation and depolymerisation are important. Role of intracellular calcium is also significant. Normal and properly timed changes of lenght of axons and dendrites are dependent on interaction of neurons and glia...
2013: Ceskoslovenská Fysiologie
Birgit Nikolay, Anne Dupressoir, Cadhla Firth, Ousmane Faye, Cheikh S Boye, Mawlouth Diallo, Amadou A Sall
BACKGROUND: Usutu virus (USUV), a flavivirus belonging to the Japanese encephalitis serocomplex, was identified in South Africa in 1959 and reported for the first time in Europe in 2001. To date, full length genome sequences have been available only for the reference strain from South Africa and a single isolate from each of Austria, Hungary, and Italy. METHODS: We sequenced four USUV isolates from Senegal and the Central African Republic (CAR) between 1974 and 2007 and compared the sequence data to USUV strains from Austria, Hungary, Italy, and South Africa using a Bayesian Markov chain Monte Carlo method...
2013: Virology Journal
Konstantin Dorst, Wolfgang Frey, Dongren Wang, Michael Buchmeiser
The title compound, [Ru(C7F5O2)2(C10H14)(C21H24N2)]·2CH2Cl2, is formed as an orange crystalline powder by the reaction of RuCl2(p-cymene)(IMes) and AgOCOC6F5 in anhydrous tetra-hydro-furan (IMes = 1,3-dimesityl-2,3-di-hydro-1H-imidazol-2-yl-idene). The asymetric unit consists of two independent [Ru(C6F5COO)2(η(6)-p-cymene)(IMes)] com-plexes and four dichloro-methane solvent mol-ecules. In each complex molecule, the Ru atom presents a pseudo-octa-hedral environment with the p-cymene ligand occupying three facial coordination sites, while the remaining coordination positions are occupied by the O atoms of the penta-fluoro-benzoate ligands and by the imidazolyl-idene ligand...
January 1, 2013: Acta Crystallographica. Section E, Structure Reports Online
Vincent O Nyamori, Godfrey Keru, Bernard Omondi
The asymetric unit of the title compound, [Fe(C5H5)(C17H13N2)], contains two independent mol-ecules whose conformations differ, especially in the 4-{(pyridin-4-yl)methyl-idene]amino}-phenyl unit where one is flipped by almost 180°. The cyclo-penta-dienyl rings of the ferrocene unit also exhibit different staggered conformations: in one mol-ecule the conformation is staggered by 9.43 (2)° and in the other by 24.46 (1)° from an ideal eclipsed geometry. The plane of the benzene ring is tilted away from the ferrocene group in both mol-ecules, with dihedral angles of 6...
December 1, 2012: Acta Crystallographica. Section E, Structure Reports Online
Mohamed Neifar, Amel Kamoun, Atef Jaouani, Raoudha Ellouze-Ghorbel, Semia Ellouze-Chaabouni
Statistical approaches were employed for the optimization of different cultural parameters for the production of laccase by the white rot fungus Fomes fomentarius MUCL 35117 in wheat bran-based solid medium. first, screening of production parameters was performed using an asymmetrical design 2(5)3(3)//16, and the variables with statistically significant effects on laccase production were identified. Second, inoculum size, CaCl(2) concentration, CuSO(4) concentration, and incubation time were selected for further optimization studies using a Hoke design...
2011: Enzyme Research
Valentyna V Semenaka, Oksana V Nesterova, Volodymyr N Kokozay, Volodymyr V Bon
Single crystals of the title heterometallic compound, [Fe(C(12)H(8)N(2))(3)][Cr(NCS)(4)(C(12)H(8)N(2))](2)·3CH(3)CN·H(2)O or [Fe(Cphen)(3)][Cr(NCS)(4)(phen)](2)·3CH(3)CN·H(2)O, were pre-pared using the one-pot open-air reaction of iron powder, Reineckes salt and 1,10-phenanthroline (phen) in acetonitrile. The asymetric unit consists of an [Fe(phen)(3)](2+) cation, two [Cr(phen)(NCS)(4)](-) anions, three acetonitrile solvent mol-ecules and a water mol-ecule. The Fe and Cr atoms both show a slightly distorted octa-hedral FeN(6) and CrN(6) coordination geometry with adjacent angles in the range 79...
May 1, 2012: Acta Crystallographica. Section E, Structure Reports Online
Ugur Kucuk, Sait Demirkol, Turgay Celik, Sevket Balta, Mehmet Yokusoglu
Hypertrophic cardiomyopathy (HCM) is characterized by hypertrophy of the left ventricle, with variable clinical manifestations and morphologic and hemodynamic abnormalities. False tendons (FTs) are discrete, fibromuscular structures of varying length and thickness that tranverse either left and right ventricular cavities. Left and right ventricular FTs were giving a false impression of HCM. Misdiagnosis of HCM can lead to undue anxiety, unnecessary medication, and further evaluation. Three-dimensional (3D) transthoracic echocardiography is additive to conventional two-dimensional imaging in these patients in terms of 3D perspective and anatomically correct examination...
August 2012: Echocardiography
Karuppusamy Sakthivel, Kannupal Srinivasan, Sampath Natarajan
The asymetric unit of the title mol-ecule, C(21)H(20)O(3), contains two crystallographically independent mol-ecules, A and B, which differ in the orientation of the ethyl group substituted on the naphthalene system; the dihedral angles between the ethyl group and the naphthalene system are 7.4 (3) and 68.1 (3)°, respectively, for mol-ecules A and B. The dihedral angles between the benzoyl and naphthalene groups are 64.7 (7) and 69.4 (8)°, respectively, for mol-ecules A and B. The crystal structure features four aromatic π-π stacking interactions [centroid-centroid distances = 4...
March 1, 2012: Acta Crystallographica. Section E, Structure Reports Online
Hafid Zouihri
The asymetric unit of the title salt, 3CH(5)N(2)S(+)·3Cl(-)·2CH(4)N(2)S, contains two mol-ecules of thio-urea, three (diamino-methyl-idene)sulfonium cations and three chloride anions. The crystal packing is stabilized by N-H⋯Cl, N-H⋯S, S-H⋯Cl and S-H⋯S hydrogen bonds, forming a three-dimensional network.
February 1, 2012: Acta Crystallographica. Section E, Structure Reports Online
Srdan Novak
The most frequent early symptoms of spondyloarthritides are inflammatory back pain and asymetric peripheral arthritis. Currently the mean delay between the onset of first symptoms and diagnosing ankylosing spondylitis which is the frequent type of spondyloarthritis is over 5 years. The availability of effective therapies makes an early diagnosis mandatory. The clinical symptoms of inflammatory back pain, active inflamation on MR, and positivity for HLA-B27 are the most important parameters for an early diagnosis of spondyloarthritis, especially in combination...
2011: Reumatizam
Steinar Hustad, Simone Eussen, Øivind Midttun, Arve Ulvik, Puck M van de Kant, Lars Mørkrid, Randi Gislefoss, Per M Ueland
BACKGROUND: Biomarkers and metabolites related to B vitamin function and one-carbon metabolism have been studied as predictors of chronic diseases in studies based on samples stored in biobanks. For most biomarkers, stability data are lacking or fragmentary. METHODS: Degradation and accumulation kinetics of 32 biomarkers were determined at 23 °C in serum and plasma (EDTA, heparin, and citrate) collected from 16 individuals and stored for up to 8 days. In frozen serum (-25 °C), stability was studied cross-sectionally in 650 archival samples stored for up to 29 years...
February 2012: Clinical Chemistry
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