keyword
https://read.qxmd.com/read/38192228/novel-chrna3-variants-identified-in-a-patient-with-bladder-dysfunction-dysautonomia-and-gastrointestinal-dysmotility
#21
Asha Anand, Clara C Hildebrandt, Vivek Shenoy, Richard W Sutherland
Congenital anomalies of the kidney and urinary tract (CAKUT) are estimated to be responsible for 20%-50% of congenital anomalies and are also a leading etiology of early-onset renal disease. Primary CAKUT are caused by genetic factors that impair proper in-utero genitourinary tract development and secondary CAKUT result from the influence of environmental factors. The CHRNA3 gene, which encodes the Alpha-3 subunit of the nicotinic acetylcholine receptor, is hypothesized to be associated with Megacystis-microcolon-intestinal hyperperistalsis syndrome...
January 8, 2024: American Journal of Medical Genetics. Part A
https://read.qxmd.com/read/38184952/a-case-report-on-pyelovesicostomy-of-pujo-of-pelvic-crossed-fused-renal-ectopia-with-single-ureter
#22
Abeselom Lemma Gebreamlak, Kewani Tekelebirhan Alema, Ibsa Daba Kumsa, Messay Mokennen Molla
INTRODUCTION: A pyelovesicostomy is a rare procedure that offers an alternative to difficult pyeloplasty or failed pyeloplasty in the case of PUJO of pelvic renal ectopia. In this case report, we utilized pyelovesicostomy for a dilated renal pelvis of a crossed fused ectopic pelvic kidney with a single ureter. CASE PRESENTATION: This is a 19-year-old male patient who received a diagnosis of pelvic ectopic kidney disease of 4 years duration. He was on a periodic DJ-stent exchange every 3 months at a different hospital...
January 3, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38182679/urologic-surveillance-of-persons-with-spinal-cord-injuries-a-scoping-review
#23
REVIEW
Christian Bødker, Maja F Riisbøl, Benjamin Y A Khan, Rikke M Hansen, Kaare E Severinsen
STUDY DESIGN: Scoping review - standardized according to the Equator-network and the Prisma-Statement guidelines with PRISMA-ScR. OBJECTIVES: Review the literature concerning surveillance of the urinary- and renal systems in persons with spinal cord injuries (SCI). Specifically, to assess: #1 the usability of non-invasive and non-ultrasound methods, #2 the usage of systematic ultrasound surveillance #3 patient characteristics which predispose to urinary tract abnormalities (UTA) or renal function deterioration...
January 5, 2024: Spinal Cord
https://read.qxmd.com/read/38174181/impact-of-proton-pump-inhibitors-on-kidney-function-and-chronic-kidney-disease-progression-a-systematic-review
#24
REVIEW
Mihirkumar P Parmar, Safa Kaleem, Periyaiyadever Samuganathan, Lyluma Ishfaq, Tejawi Anne, Yashaswi Patel, Sashank Bollu, Roopeessh Vempati
Proton pump inhibitors (PPIs) are widely prescribed medications for the management of various gastrointestinal disorders, primarily gastroesophageal reflux disease (GERD) and peptic ulcers. However, recent concerns have emerged regarding their potential adverse effects on kidney function and their role in the progression of chronic kidney disease (CKD). This systematic review aims to comprehensively analyze the existing literature to assess the impact of PPI use on kidney function and CKD progression. We took information from PubMed, PubMed Central (PMC), and Google Scholar articles from the last 10 years, from 2013 to 2023, and looked for links between PPI use and a number of kidney-related outcomes...
December 2023: Curēus
https://read.qxmd.com/read/38139407/the-utility-of-noninvasive-urinary-biomarkers-for-the-evaluation-of-vesicoureteral-reflux-in-children
#25
JOURNAL ARTICLE
Marius-Cosmin Colceriu, Paul Luchian Aldea, Andreea-Liana Boț Răchişan, Bogdan Bulată, Dan Delean, Alina Grama, Alexandra Mititelu, Roxana Maria Decea, Alexandra Sevastre-Berghian, Simona Clichici, Tudor Lucian Pop, Teodora Mocan
Vesicoureteral reflux (VUR) is one of the most important disorders encountered in pediatric nephrology due to its frequency and potential evolution to chronic kidney disease (CKD). The aim of our study was to identify noninvasive and easy-to-determine urinary markers to facilitate the diagnosis and staging of VUR. We performed a cross-section study including 39 patients with VUR followed over three years (August 2021-September 2023) and 39 children without urinary disorder (the control group). We measured the urinary concentration of interleukin-6 (IL-6), cathelicidin (LL-37), and neutrophil gelatinase-associated lipocalin (NGAL) in VUR and healthy controls...
December 17, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38127660/troubleshooting-tips-for-diagnosing-complex-fetal-genitourinary-malformations
#26
JOURNAL ARTICLE
April M Griffith, Paula J Woodward, Anne M Kennedy
Fetal genitourinary anomalies can present a diagnostic challenge for the radiologist. The absence of a normally located kidney may represent agenesis or be secondary to a fusion or migration abnormality. A dilated renal pelvis should prompt evaluation for a specific cause, including ureteropelvic junction obstruction, reflux, or an obstructed duplicated system. Cystic parenchymal changes are characteristic of a multicystic dysplastic kidney but may also be seen in obstructive cystic dysplasia. There are numerous causes of megacystis including chromosomal (trisomy 18 syndrome), obstruction (posterior urethral valves, urethral atresia), or muscular dysfunction (prune belly syndrome, megacystis microcolon intestinal hypoperistalsis syndrome)...
January 2024: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://read.qxmd.com/read/38095683/-imaging-in-children-and-adolescents-with-urinary-tract-infections
#27
REVIEW
J D Moritz
CLINICAL/METHODOLOGICAL PROBLEM: Urinary tract infections are among the most common infectious diseases in childhood. The task of imaging is to detect predisposing factors, such as urinary transport disorders, vesicoureteral reflux, as well as complications such as abscesses or pyonephrosis in addition to possible morphological changes of the kidneys and the draining urinary tract during an infection. STANDARD RADIOLOGICAL PROCEDURES: The initial diagnostic imaging technique is generally sonography...
December 14, 2023: Radiologie (Heidelb)
https://read.qxmd.com/read/38024545/transitional-metaplasia-of-renal-collecting-ducts-in-vesicoureteral-reflux-and-chronic-pyelonephritis-an-immunohistochemical-study-of-a-case-and-review-of-the-literature
#28
Naser Tayyebi Meibodi, Salman Soltani, Farnaz Torabian
The capability of the urinary tract to undergo metaplastic changes such as squamous, intestinal, glandular, mucinous, or ciliated epithelium in renal pelvis has been previously reported, which hypothetically is due to the mechanical irritation of the transitional epithelium. However, transitional metaplasia is a rare presentation in the collecting ducts. The aim of this paper was to report this type of extremely rare metaplasia and to inform pathologists that they may encounter this kind of metaplasia. A 25-year-old man, a known case of vesicoureteral reflux (VUR), referred to the Imam Reza Hospital; affiliated to the Mashhad University of Medical Sciences, for bilateral nephrectomy...
2023: Iranian Journal of Pathology
https://read.qxmd.com/read/38002736/fetal-renal-duplicated-collecting-system-at-14-16-weeks-of-gestation
#29
JOURNAL ARTICLE
Nizar Khatib, Moshe Bronshtein, Gal Bachar, Ron Beloosesky, Yuval Ginsberg, Osnat Zmora, Zeev Weiner, Ayala Gover
(1) Background: To examine the incidence of the prenatal diagnosis of the renal double-collecting system (rDCS) and describe its clinical outcome and associated genetic abnormalities. (2) Methods: This retrospective study included women who attended the obstetric clinic for early fetal anatomic sonography with findings of a renal DCS. Diagnosis was conducted by an expert sonographer using defined criteria. (3) Results: In total, 29,268 women underwent early ultrasound anatomical screening at 14-16 weeks, and 383 cases of rDCS were diagnosed (prevalence: 1:76)...
November 16, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37993352/a-machine-learning-algorithm-predicting-risk-of-dilating-vur-among-infants-with-hydronephrosis-using-utd-classification
#30
JOURNAL ARTICLE
Hsin-Hsiao Scott Wang, Michael Li, Dylan Cahill, John Panagides, Tanya Logvinenko, Jeanne Chow, Caleb Nelson
BACKGROUNDS: Urinary Tract Dilation (UTD) classification has been designed to be a more objective grading system to evaluate antenatal and post-natal UTD. Due to unclear association between UTD classifications to specific anomalies such as vesico-ureteral reflux (VUR), management recommendations tend to be subjective. OBJECTIVE: We sought to develop a model to reliably predict VUR from early post-natal ultrasound. STUDY DESIGN: Radiology records from single institution were reviewed to identify infants aged 0-90 days undergoing early ultrasound for antenatal UTD...
November 9, 2023: Journal of Pediatric Urology
https://read.qxmd.com/read/37989212/long-term-follow-up-of-patients-with-nonrefluxing-hydronephrosis
#31
JOURNAL ARTICLE
Songül Yılmaz, Zeynep Birsin Özçakar, Nilgun Cakar, Burcu Biral Coşkun, Berk Burgu, Fatoş Yalcinkaya
BACKGOUND: The aim of this study is to examine the long-term prognosis of children with ureteropelvic junction obstruction-like hydronephrosis (UPJO-like HN). PATIENTS AND METHODS: The files of children with hydronephrosis (HN) were analyzed retrospectively. Patients with vesicoureteral reflux (VUR) and other genitourinary anomalies were excluded. The final status of the HN, the need for surgery, and urinary tract infection (UTI) frequency were evaluated. RESULTS: The study included 219 patients with 302 renal units (RU) with HN...
November 21, 2023: Klinische Pädiatrie
https://read.qxmd.com/read/37965887/role-of-dexamethasone-in-controlling-the-proinflammatory-cytokine-cascade-in-the-first-episode-of-paediatric-acute-pyelonephritis
#32
JOURNAL ARTICLE
Neus Rius-Gordillo, Natàlia Ferré, Juan David González, Zaira Ibars, Ester Parada-Ricart, Joaquín Escribano
AIM: Febrile urinary tract infection is a common bacterial infection in childhood. The kidney damage after acute pyelonephritis (APN) could be related to the stimulation of the proinflammatory response. We aimed to investigate the role of inflammatory cytokines and the effect of dexamethasone after a first episode of APN. METHODS: Subanalysis of the DEXCAR RCT in which children with confirmed APN (1 month-14 years) were randomly assigned to receive a 3 days course of either intravenous dexamethasone or placebo...
November 15, 2023: Acta Paediatrica
https://read.qxmd.com/read/37965387/obstructive-uropathy-caused-by-massive-fecal-impaction-in-a-patient-with-congenital-anorectal-malformation-and-neurogenic-bladder
#33
Soo Jin Lee, Seok Young Cho, Wonkyo Yi, Kyung Pyo Kang
Anorectal malformations (ARMs) comprise a broad spectrum of congenital anomalies involving both anorectal and urogenital tracts. After diagnosis, urological problems should be evaluated in addition to surgical correction of ARMs. Commonly encountered urological problems in patients with ARMs are recurrent urinary tract infections, vesicoureteral reflux, and chronic kidney disease. Therefore, the proper timing of urination and appropriate defecation habits are essential for preserving renal function in patients with ARMs...
October 2023: Curēus
https://read.qxmd.com/read/37961019/peristalsis-prevents-ureteral-dilation
#34
JOURNAL ARTICLE
Kourosh Kalayeh, J Brian Fowlkes, Haotian Xie, William W Schultz, Bryan S Sack
PURPOSE: The etiology of ureteral dilation in primary nonrefluxing, nonobstructing megaureters is still not well understood. Impaired ureteral peristalsis has been theorized as one of the contributing factors. However, ureteral peristalsis and its "normal" function is not well defined. In this study, using mathematical modeling techniques, we aim to better understand how ureteral peristalsis works. This is the first model to consider clinically observed, back-and-forth, cyclic wall longitudinal motion during peristalsis...
November 13, 2023: Neurourology and Urodynamics
https://read.qxmd.com/read/37955763/transfer-of-chromium-from-environment-to-fish-in-east-kolkata-wetlands-evaluation-by-structural-equation-modeling
#35
JOURNAL ARTICLE
Debkanta Ghosh, Samir Kumar Saha, Anilava Kaviraj, Subrata Saha
Chromium (Cr) is a significant pollutant in the effluents from leather industries and domestic city sewage. Cr was determined in water, sediment, and different tissues (gill, muscle, intestine, liver, and kidney) of Nile tilapia, Oreochromis niloticus harvested from wastewater-fed aquaculture (WFA) situated at Bamonghata, Bantala, Chowbaga and Chingrighata of East Kolkata Wetlands (EKW), a Ramsar site in West Bengal, India. The results showed that Cr concentration in surface water ranged between 0.05 to 0.15 mg/L, while Cr was detected at high concentration (100-300 mg/kg) in the sediment soil of the first three WFAs and in moderate concentration (50-110 mg/kg) in Chingrighata WFA...
November 13, 2023: Environmental Monitoring and Assessment
https://read.qxmd.com/read/37932198/evaluating-the-requirement-of-ultrasonography-for-children-with-their-first-urinary-tract-infection
#36
JOURNAL ARTICLE
Orkun Aydin, Selmin Karademir, Mehmet Bülbül
BACKGROUND: Management of urinary tract infection (UTI) in children remains important. It may be the first sign for a possible underlying congenital abnormalities for the kidney and urinary tract (CAKUT). This study examined whether performing renal and bladder ultrasonography (RBUS) only for children who have a pathogen other than E. coli during their first urinary tract infection (UTI), or who experience UTI recurrence, would result in more missed diagnoses of kidney anomalies. METHODS: Patients aged between 2 months and 2 years who were seen in a tertiary pediatric hospital during a 2-year period and diagnosed with UTI were included...
October 28, 2023: Journal of Pediatric Urology
https://read.qxmd.com/read/37927026/-causes-and-countermeasures-of-complications-after-bariatric-surgery
#37
JOURNAL ARTICLE
Hong-Bin Shi, Yong Dai, Xiao-Feng Li, Meng-Fan Yang, Jian-Li Gao, Jin Dong
Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy characterized by simple operation and few postoperative complications have gradually become the two most commonly used surgical methods in clinical practice.A series of complications often occur after bariatric surgery,including gallstone disease,anemia,malnutrition,gastroesophageal reflux disease,kidney stones,and birth defects in offspring of women of childbearing age.There are controversies regarding the causes and countermeasures of these complications...
October 2023: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://read.qxmd.com/read/37925278/vesicoureteral-reflux-by-contrast-ultrasound-comparison-with-voiding-and-retrograde-urethrocystography-a-prospective-accuracy-study
#38
JOURNAL ARTICLE
Marcelo Straus Takahashi, Mauricio Gustavo Ieiri Yamanari, Pedro Henrique de Marqui Moraes, Roberto Iglesias Lopes, Maria Cristina Chammas
INTRODUCTION: Diagnosis of vesicoureteral reflux (VUR) plays an important role in the management and follow-up of children presenting with urinary tract infection. This study compared voiding uronosography (VUS) as a diagnostic method for the diagnosis of VUR with the "gold standard", voiding or micturating cystourethrography (MCU). The objective of the study is not only to compare the effectiveness of both methods, but also to assess the feasibility of implementing VUS technically and economically in a large tertiary radiology center in South America...
October 18, 2023: Journal of Pediatric Urology
https://read.qxmd.com/read/37903379/pathogenesis-and-prognosis-of-intrarenal-reflux
#39
JOURNAL ARTICLE
Ioanna Gkalonaki, Evangelia Schoina, Michail Anastasakis, Ioannis Patoulias
Scar development in the children's renal cortex with vesicoureteral reflux (VUR) is one of the most important parameters of prognosis. It can develop regardless of the chosen treatment, even after the regression of VUR. The shape of the renal papillae, the ascending urinary tract infection, the greater than third-degree VUR, and finally the increased intra-calyceal pressure, induce the formation of renal scarring in the renal parenchyma. Renal scarring may complicate VUR independently of the therapeutic strategy (conservative or operative) and its regression...
July 30, 2023: Folia Medica Cracoviensia
https://read.qxmd.com/read/37897526/evidence-based-clinical-practice-guideline-for-management-of-urinary-tract-infection-and-primary-vesicoureteric-reflux
#40
REVIEW
Pankaj Hari, Jitendra Meena, Manish Kumar, Aditi Sinha, Ranjeet W Thergaonkar, Arpana Iyengar, Priyanka Khandelwal, Sudha Ekambaram, Priya Pais, Jyoti Sharma, Madhuri Kanitkar, Arvind Bagga
We present updated, evidence-based clinical practice guidelines from the Indian Society of Pediatric Nephrology (ISPN) for the management of urinary tract infection (UTI) and primary vesicoureteric reflux (VUR) in children. These guidelines conform to international standards; Institute of Medicine and AGREE checklists were used to ensure transparency, rigor, and thoroughness in the guideline development. In view of the robust methodology, these guidelines are applicable globally for the management of UTI and VUR...
October 28, 2023: Pediatric Nephrology
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