keyword
MENU ▼
Read by QxMD icon Read
search

involuntary movement

keyword
https://www.readbyqxmd.com/read/29651625/clinical-characteristics-and-prognosis-of-severe-anti-n-methyl-d-aspartate-receptor-encephalitis-patients
#1
Yan Zhang, Gang Liu, Mengdi Jiang, Weibi Chen, Yanbo He, Yingying Su
BACKGROUND AND PURPOSE: Data concerning the characteristics and duration of the critical manifestations, treatment response, and long-term outcomes of severe anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis patients compared to those of non-severe patients are limited. This observational study was performed to explore the clinical characteristics and long-term outcomes of severe anti-NMDAR encephalitis patients. METHODS: According to their characteristics on admission to the neurology intensive care unit, patients with anti-NMDAR encephalitis were divided into a severe group and a non-severe group...
April 12, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/29611150/nociceptive-response-to-l-dopa-induced-dyskinesia-in-hemiparkinsonian-rats
#2
G C Nascimento, K Bariotto-Dos-Santos, C R A Leite-Panissi, E A Del-Bel, M Bortolanza
Non-motor symptoms are increasingly identified to present clinical and diagnostic importance for Parkinson's disease (PD). The multifactorial origin of pain in PD makes this symptom of great complexity. The dopamine precursor, L-DOPA (L-3,4-dihydroxyphenylalanine), the classic therapy for PD, seems to be effective in pain threshold; however, there are no studies correlating L-DOPA-induced dyskinesia (LID) and nociception development in experimental Parkinsonism. Here, we first investigated nociceptive responses in a 6-hydroxydopamine (6-OHDA)-lesioned rat model of Parkinson's disease to a hind paw-induced persistent inflammation...
April 2, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29599901/management-of-restless-legs-syndrome-in-chronic-liver-disease-a-challenge-for-the-correct-diagnosis-and-therapy
#3
Rita Moretti, Paola Caruso, Marzia Tecchiolli, Silvia Gazzin, Claudio Tiribelli
AIM: To investigate the association between restless legs syndrome (RLS) and well-defined chronic liver disease, and the possible therapeutic options. METHODS: Two hundred and eleven patients with chronic liver disease, complaining of sleep disturbances, painful leg sensation and daily sleepiness, were included. Patients with persistent alcohol intake, recent worsening of clinical conditions, or hepatitis C virus were excluded. Diagnosis of RLS was suggested by the Johns Hopkins questionnaire and verified by fulfilling the diagnostic criteria by Allen...
March 27, 2018: World Journal of Hepatology
https://www.readbyqxmd.com/read/29592842/mirror-movements-are-linked-to-executive-control-in-healthy-and-brain-injured-adults
#4
Joseph Tisseyre, David Amarantini, Alexandre Chalard, Philippe Marque, David Gasq, Jessica Tallet
It has been shown that brain-injured patients have exacerbated mirror movements (MM). MM are involuntary contractions occurring in homologous muscles contralateral to voluntary movements, particularly in distal upper limb muscles. Attentional and inhibitory processes have been proposed as key factors to explain the level of MM. However, the link between MM and attentional/inhibitory processes has never been formally tested. The present study aims to test this link in 24 right-handed healthy adults and eight chronic brain-injured patients...
March 25, 2018: Neuroscience
https://www.readbyqxmd.com/read/29578611/calcium-channel-blockers-for-antipsychotic-induced-tardive-dyskinesia
#5
REVIEW
Adib Essali, Karla Soares-Weiser, Hanna Bergman, Clive E Adams
BACKGROUND: Schizophrenia and related disorders affect a sizable proportion of any population. Antipsychotic medications are the primary treatment for these disorders. Antipsychotic medications are associated with a variety of adverse effects including tardive dyskinesia. Dyskinesia is a disfiguring movement disorder of the orofacial region that can be tardive (having a slow or belated onset). Tardive dyskinesia is difficult to treat, despite experimentation with several treatments. Calcium channel blockers (diltiazem, nifedipine, nimodipine, verapamil, flunarizine) have been among these experimental treatments...
March 26, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29573455/comparative-in-vitro-and-in-vivo-effects-of-chlorpyrifos-oxon-in-the-outbred-cd-1-mouse-mus-musculus-and-great-plains-toad-anaxyrus-cognatus
#6
Tim Anderson, Jing Liu, Scott McMurry, Carey Pope
We compared biochemical, functional and behavioral responses to the organophosphorus anticholinesterase chlorpyrifos oxon (CPO) in mice (Mus musculus, CD-1) and toads (Anaxyrus cognatus, Great Plains toad). Toads were substantially less sensitive to acute lethality of CPO based on the maximum tolerated (nonlethal) dose (MTD: toads, 77 mg/kg; mice, 5.9 mg/kg). Sublethal exposures led to classical signs of toxicity (increased involuntary movements, autonomic secretions) in mice, but hypo-activity in toads...
March 24, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29570969/tardive-dyskinesia-recognition-patient-assessment-and-differential-diagnosis
#7
Rakesh Jain, Christoph U Correll
Tardive dyskinesia (TD) is an involuntary movement disorder associated with antipsychotic treatment. Because of the serious and potentially irreversible nature of TD, accurate diagnosis is crucial. However, diagnosing TD can be challenging, since the subtle and often fluctuating symptoms can be easily mistaken for symptoms of mental illness or other side effects. Although the risk of developing TD in relation to treatment with second-generation antipsychotics is lower than that associated with first-generation antipsychotics, the risk still exists and may be greater than once believed...
March 20, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29568690/altered-functional-connectivity-in-blepharospasm-orofacial-dystonia
#8
Angela Jochim, Yong Li, Gina Gora-Stahlberg, Tobias Mantel, Maria Berndt, Florian Castrop, Christian Dresel, Bernhard Haslinger
Introduction: Blepharospasm is characterized by involuntary eyelid spasms. It can be associated with perioral dystonia (Meige's syndrome or orofacial dystonia). We aimed at studying resting-state functional brain connectivity in these patients and its potential modulation by therapeutic botulinum toxin injections. Methods: We performed resting-state functional MRI and a region of interest-based analysis of functional connectivity in 13 patients with blepharospasm/Meige's syndrome in comparison to 13 healthy controls...
January 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29568322/modelling-of-soft-connective-tissues-to-investigate-female-pelvic-floor-dysfunctions
#9
Aroj Bhattarai, Manfred Staat
After menopause, decreased levels of estrogen and progesterone remodel the collagen of the soft tissues thereby reducing their stiffness. Stress urinary incontinence is associated with involuntary urine leakage due to pathological movement of the pelvic organs resulting from lax suspension system, fasciae, and ligaments. This study compares the changes in the orientation and position of the female pelvic organs due to weakened fasciae, ligaments, and their combined laxity. A mixture theory weighted by respective volume fraction of elastin-collagen fibre compound (5%), adipose tissue (85%), and smooth muscle (5%) is adopted to characterize the mechanical behaviour of the fascia...
2018: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/29564504/stability-of-vertical-posture-explored-with-unexpected-mechanical-perturbations-synergy-indices-and-motor-equivalence
#10
Momoko Yamagata, Ali Falaki, Mark L Latash
We explored the relations between indices of mechanical stability of vertical posture and synergy indices under unexpected perturbations. The main hypotheses predicted higher posture-stabilizing synergy indices and higher mechanical indices of center of pressure stability during perturbations perceived by subjects as less challenging. Healthy subjects stood on a force platform and held in fully extended arms a bar attached to two loads acting downward and upward. One of the loads was unexpectedly released by the experimenter causing a postural perturbations...
March 21, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29558228/categorisation-of-goals-set-using-goal-attainment-scaling-for-treatment-of-leg-spasticity-a-multicentre-analysis
#11
Stephen Ashford, Heather Williams, Ajoy Nair, Samantha Orridge, Lynne Turner-Stokes
BACKGROUND: Goal-classification of person-centred goals, using Goal Attainment Scaling for leg spasticity treatment. METHODS: The study was conducted in two phases: phase I, a retrospective review to evaluate categories of goal set in routine clinical practice. Findings were used to design a goal classification system. Phase II, a multi-centre study to confirm the goal categories. Goals set (n = 270) were analysed from data collected at three centres in the UK (one centre for phase I)...
March 20, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29552749/miscellaneous-treatments-for-antipsychotic-induced-tardive-dyskinesia
#12
REVIEW
Karla Soares-Weiser, John Rathbone, Yusuke Ogawa, Kiyomi Shinohara, Hanna Bergman
BACKGROUND: Antipsychotic (neuroleptic) medication is used extensively to treat people with chronic mental illnesses. Its use, however, is associated with adverse effects, including movement disorders such as tardive dyskinesia (TD) - a problem often seen as repetitive involuntary movements around the mouth and face. This review, one in a series examining the treatment of TD, covers miscellaneous treatments not covered elsewhere. OBJECTIVES: To determine whether drugs, hormone-, dietary-, or herb-supplements not covered in other Cochrane reviews on TD treatments, surgical interventions, electroconvulsive therapy, and mind-body therapies were effective and safe for people with antipsychotic-induced TD...
March 19, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29550415/rhythmic-neck-muscle-spasms-and-upper-limb-muscle-myoclonic-jerks-as-an-unusual-initial-presentation-of-posttraumatic-cervicothoracic-syringomyelia-a-case-report
#13
Hsin-Chin Lin, Yu-Lin Tsai, Wen-Chung Tsai
Posttraumatic syringomyelia with an initial presentation of involuntary movement is rare. We describe a 25-year-old patient who sustained complete traumatic spinal cord injury at the thoracic level and presented with rhythmic neck muscle spasms and upper limb muscle myoclonic jerks 1 month after trauma. Magnetic resonance imaging revealed syrinx formation between C3 and T1. Lumbar-peritoneal shunt and decompression were performed. The symptoms completely disappeared after surgery. This report highlights that rhythmic neck muscle spasms and upper limb muscle myoclonic jerks can be the initial and only manifestations of syringomyelia...
March 14, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29545767/involuntary-neuromuscular-coupling-between-the-thumb-and-finger-of-stroke-survivors-during-dynamic-movement
#14
Christopher L Jones, Derek G Kamper
Finger-thumb coordination is crucial to manual dexterity but remains incompletely understood, particularly following neurological injury such as stroke. While being controlled independently, the index finger and thumb especially must work in concert to perform a variety of tasks requiring lateral or palmar pinch. The impact of stroke on this functionally critical sensorimotor control during dynamic tasks has been largely unexplored. In this study, we explored finger-thumb coupling during close-open pinching motions in stroke survivors with chronic hemiparesis...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29542022/pilot-single-blind-trial-of-abobotulinumtoxina-in-oromandibular-dystonia
#15
Laura M Scorr, Michael R Silver, John Hanfelt, Elaine Sperin, Alan Freeman, H A Jinnah, Stewart A Factor
Oromandibular dystonia (OMD) causes involuntary movements of masticatory and lingual muscles impairing eating, speaking, and swallowing. Treatment options are limited. The objective of this study was to determine the safety and efficacy of abobotulinumtoxinA (aboBoNTA) in OMD. A dose-finding study (phase 1) followed by a single session, prospective, single-blind trial (phase 2) was carried out. OMD subjects were evaluated at baseline, 6 and 12 weeks. Muscles injected were tailored to individual symptoms using EMG guidance, but the aboBoNTA dose for each muscle was pre-specified based on phase 1 results...
March 14, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29532440/pooled-analyses-of-phase-iii-studies-of-ads-5102-amantadine-extended-release-capsules-for-dyskinesia-in-parkinson-s-disease
#16
Lawrence W Elmer, Jorge L Juncos, Carlos Singer, Daniel D Truong, Susan R Criswell, Sotirios Parashos, Larissa Felt, Reed Johnson, Rajiv Patni
BACKGROUND: Although levodopa is considered the most effective pharmacotherapy for motor symptoms of Parkinson's disease (PD), chronic use is associated with motor complications, including fluctuating response and unpredictable, involuntary movements called dyskinesia. ADS-5102 (amantadine) extended-release (ER) capsules (GOCOVRITM ) is a recent US FDA-approved treatment for dyskinesia in PD patients. ADS-5102 is a high-dose, ER formulation of amantadine, administered orally once daily at bedtime, that achieves high plasma drug concentrations throughout the day...
March 12, 2018: CNS Drugs
https://www.readbyqxmd.com/read/29530712/genetic-disruption-of-the-nuclear-receptor-nur77-nr4a1-in-rat-reduces-dopamine-cell-loss-and-l-dopa-induced-dyskinesia-in-experimental-parkinson-s-disease
#17
Claude Rouillard, Joanie Baillargeon, Brigitte Paquet, Michel St-Hilaire, Jérôme Maheux, Catherine Lévesque, Noémie Darlix, Simon Majeur, Daniel Lévesque
Parkinson's disease (PD) is an idiopathic progressive neurodegenerative disorder characterized by the loss of midbrain dopamine neurons. Levodopa (l-dopa) is the main pharmacological approach to relieve PD motor symptoms. However, chronic treatment with l-Dopa is inevitably associated with the generation of abnormal involuntary movements (l-Dopa-induced dyskinesia). We have previously shown that Nr4a1 (Nur77), a transcription factor of the nuclear receptor family, is closely associated with dopamine neurotransmission in the mature brain...
March 9, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29526790/selegiline-increases-on-time-without-exacerbation-of-dyskinesia-in-6-hydroxydopamine-lesioned-rats-displaying-l-dopa-induced-wearing-off-and-abnormal-involuntary-movements
#18
Hiroko Tsunekawa, Kazue Takahata, Motoki Okano, Toshiko Ishikawa, Hiroshi Satoyoshi, Tetsuya Nishimura, Naoya Hoshino, Shizuko Muraoka
3,4-Dihydroxy-L-phenylalanine (L-Dopa) remains the most effective drug for treating the motor symptoms of Parkinson's disease (PD). However, its long-term use is limited due to motor complications such as wearing-off and dyskinesia. A clinical study in PD patients with motor complications has demonstrated that selegiline, a monoamine oxidase type B inhibitor, is effective in reducing off time without worsening dyskinesia, although another study has shown worsening dyskinesia. Here, using unilateral 6-hydroxydopamine-lesioned rats showing degeneration of nigrostriatal dopaminergic neurons and L-Dopa-induced motor complications, we determined the efficacy of selegiline in controlling L-Dopa-induced motor fluctuations and exacerbated dyskinesia...
March 8, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29525943/pelvic-floor-muscle-activity-during-jumps-in-continent-and-incontinent-women-an-exploratory-study
#19
Helene Moser, Monika Leitner, Patric Eichelberger, Annette Kuhn, Jean-Pierre Baeyens, Lorenz Radlinger
PURPOSE: Stress urinary incontinence (SUI) symptoms can be provoked during impact loads such as vertical jumps. To investigate and compare pelvic floor muscle (PFM) activity in women with SUI and continent women (CON) during drop jumps (DJ) and counter movement jumps (CMJ) could clarify the activity of the PFMs during impact loads. METHODS: A tripolar vaginal probe was used to record surface electromyographic (EMG) activity of the PFMs during DJ and CMJ. Time intervals of 30 ms were used to parameterize data from 30 ms before (pre-activity) to 150 ms after (reflex activity) ground contact on a force plate during the landing and take-off phase...
March 10, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29525397/correlation-between-dopamine-receptor-d2-expression-and-presence-of-abnormal-involuntary-movements-in-wistar-rats-with-hemiparkinsonism-and-dyskinesia
#20
P A Caro Aponte, C A Otálora, J C Guzmán, L F Turner, J P Alcázar, E L Mayorga
Parkinson's disease (PD) is characterised by motor alterations, which are commonly treated with L-DOPA. However, long-term L-DOPA use may cause dyskinesia. Although the pathogenic mechanism of L-DOPA-induced dyskinesia is unclear, the condition has been associated with alterations in dopamine receptors, among which D2 receptors (D2R) have received little attention. This study aims to: (i)develop and standardise an experimental model of L-DOPA-induced dyskinesia in rats with hemiparkinsonism; and (ii)evaluate the correlation between D2R expression and presence of abnormal involuntary movements (AIM)...
March 7, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
keyword
keyword
68716
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"