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radiation oncology radiotherapy cancer

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https://www.readbyqxmd.com/read/29773816/experimental-investigation-of-radiobiology-in-head-and-neck-cancer-cell-lines-as-a-function-of-hpv-status-by-mtt-assay
#1
Paul Reid, Puthenparampil Wilson, Yanrui Li, Loredana G Marcu, Alexander H Staudacher, Michael P Brown, Eva Bezak
Head and neck cancers (HNCs) are aggressive epithelial tumours frequently treated using radiation. HNC biology shows distinctions dependent on the oncologic involvement of the human papilloma virus (HPV). Clinically, HPV positive HNCs respond better to radiotherapy but few in vitro data demonstrate radiobiological differences explaining differences in clinical outcomes. This pilot study examined radiobiological responses to irradiation and subsequent regeneration in two HNC cell lines (HPV positive and negative)...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29773414/hypofractionated-whole-breast-irradiation-with-or-without-boost-in-elderly-patients-clinical-evaluation-of-an-italian-experience
#2
Maria Carmen De Santis, Francesca Bonfantini, Francesca Di Salvo, Alba Fiorentino, Michela Dispinzieri, Mariangela Caputo, Serena Di Cosimo, Gabriella Mariani, Massimiliano Gennaro, Vito Cosentino, Milena Sant, Emanuele Pignoli, Riccardo Valdagni, Laura Lozza
PURPOSE: To examine local control, disease-free survival (DFS), and toxicity in elderly (≥ 65 years) breast cancer patients treated with hypofractionated radiotherapy (hypo-RT) with or without a boost to the tumor bed. PATIENTS AND METHODS: The study was conducted on 752 patients treated from April 2009 to February 2017. Patients received 42.4 Gy in 16 daily fractions (2.65 Gy per fraction). A boost was only administered in cases of grade 3 primary tumor and close or positive margins...
April 22, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29771796/a-population-based-cohort-analysis-of-chemoradiation-versus-radiation-alone-for-definitive-treatment-of-stage-i-anal-cancer-in-older-patients
#3
Michael Buckstein, Yotam Arens, Juan Wisnivesky, Michael Gaisa, Stephen Goldstone, Keith Sigel
BACKGROUND: Although the benefit of chemoradiation over radiation therapy alone has been shown in randomized trials for stage II to III squamous cell of the anus, this benefit is not clear for patients with stage I cancer. Nevertheless, most societal recommendations endorse chemoradiation for patients with stage I squamous cell carcinoma of the anus despite the lack of proven benefit and potential increase in toxicity. OBJECTIVE: The purpose of this study was to determine whether outcomes are improved with the addition of chemotherapy versus radiation alone for stage I squamous cell carcinoma of the anus...
May 15, 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29764588/-correlations-between-ape1-ref-1-icam-1-and-il-17a-levels-in-serum-and-radiation-pneumonitis-for-local-advanced-non-small-cell-lung-cancer-patients
#4
Leiming Guo, Gaofeng Ding, Wencai Xu, Hong Ge, Yue Jiang, Yufei Lu
BACKGROUND: The main manifestations of radiation pneumonitis are injury of alveolar epithelial and endothelial cells, abnormal expression of cytokines, abnormal proliferation of fibroblasts and synthesis of fibrous matrix. The occurrence of radiation pneumonitis is associated with multiplecytokine level abnormality. These cytokines can also be used as bio-markers to predict the occurrence of radiation pneumonitis. This study was to evaluate the correlation between the change of apurinic/apyrimidinic endonuclease 1/redox factor-1 (Ape1/Ref-1), intercellular adhesion molecules 1 (ICAM-1) and interleukin-17A (IL-17A) before and after radiotherapy and radiation pneumonitis for local advanced non-small cell lung cancer (NSCLC) patients with concurrent chemoradiotherapy...
May 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29764186/patterns-of-symptom-control-and-palliative-care-focused-original-research-articles-in-the-international-journal-of-radiation-oncology-biology-physics-and-the-radiotherapy-and-oncology-journal-2005-2014
#5
Diana D Shi, Julia DiGiovanni, Sonia Skamene, Sarah Noveroske Philbrick, Yanbing Wang, Elizabeth A Barnes, Edward Chow, Adam Sullivan, Tracy A Balboni
BACKGROUND: A significant portion of radiation treatment (30-40%) is delivered with palliative intent. Given the frequency of palliative care (PC) in radiation oncology, we determined the patterns of research focusing on symptom control and palliative care (SCPC) in two prominent radiation oncology journals from 2005-2014. METHODS: Original research manuscripts published from 2005-2014 in the International Journal of Radiation Oncology *Biology* Physics (Red Journal) and the Radiotherapy and Oncology Journal (Green Journal) were reviewed to categorize articles as PC and/or SCPC...
April 2018: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29761228/patterns-of-care-analysis-for-head-neck-cancer-of-unknown-primary-site-a-survey-inside-the-german-society-of-radiation-oncology-degro
#6
Jens Müller von der Grün, Dimitra Bon, Claus Rödel, Panagiotis Balermpas
BACKGROUND: Due to the absence of randomized trials, the optimal management for squamous cell cancer of unknown primary in the head and neck region (SCCHN CUP) remains controversial. Current strategies are based on retrospective studies, clinical experience, and institutional policies. METHODS: An anonymous questionnaire with a total of 24 questions was created and distributed by the use of an online version (Google Forms®, Google, Mountain View, CA, USA) as well as a printout version as equivalent option...
May 14, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29734694/hearing-loss-in-adult-survivors-of-childhood-cancer-treated-with-radiotherapy
#7
Amber Khan, Amy Budnick, Dana Barnea, Darren R Feldman, Kevin C Oeffinger, Emily S Tonorezos
The ototoxic effects of radiotherapy have been poorly characterized. We examined adult survivors of childhood cancer who were treated with radiotherapy, which included the head, before the age of 22 years and between 1952 and 2016. Those who received platinum chemotherapy were excluded. Demographic, diagnosis, and treatment outcomes were captured. Audiograms were graded using the Chang and International Society of Paediatric Oncology ototoxicity (SIOP) scales. Among 276 patients with a history of radiation to sites that included the brain, orbit, nasopharynx, and total body irradiation, the median age at treatment was 10...
May 4, 2018: Children
https://www.readbyqxmd.com/read/29728842/patients-characteristics-informing-practice-improving-individualized-nursing-care-in-the-radiation-oncology-setting
#8
Pauline M Rose
PURPOSE: A large number of patients attend for radiotherapy daily. Primary nurses in the study settings aim to individualize care for their patients. The individual characteristics of patients may determine their perceptions of nursing care, and provide guidance in tailoring their care. This study aimed to assess patients' personal characteristics on their perceptions of individualized care (IC) provided by nurses during a course of radiotherapy, and to determine predictor variables that may inform nursing practice...
May 4, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29728233/multifunctional-chitosan-capped-gold-nanoparticles-for-enhanced-cancer-chemo-radiotherapy-an-invitro-study
#9
Mohamed Mahmoud Fathy, Fayrouz S Mohamed, NihalSaad Elbialy, Wael M Elshemey
Over the last decade, chemo-radiotherapy represented a well-established paradigm for cancer treatment. Developing new strategies to promote the therapeutic efficacy while reducing toxic side effects of chemo-radiotherapy is a main research objective in cancer therapy. A promising new oncological strategy for enhancing chemo-radiotherapy against cancer involves the utilization of multifunctional nanoparticles (nanocarriers and radiosensitizers). In this work, Chitosan-Capped Gold Nanoparticles (CS-GNPs) were synthesized and loaded with an anticancer agent, Doxorubicin (CS-GNPs-DOX)...
April 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29727314/the-university-of-florida-department-of-radiation-oncology-guidelines-for-treatment-of-differentiated-thyroid-cancer-with-i-131-or-external-beam-radiotherapy
#10
Robert J Amdur, Roi Dagan
The purpose of this paper is to summarize the University of Florida Department of Radiation Oncology guidelines for treatment of differentiated thyroid cancer with I-131 or external-beam radiotherapy. This article is not meant to compete with the many excellent book chapters and consensus guidelines that present comprehensive discussions of treatment options. This is a streamlined, "How we do it?" reference without substantial discussion of background or supporting data. To serve as a treatment reference, the great majority of the information is presented in topic-specific tables...
May 4, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29726389/combining-precision-radiotherapy-with-molecular-targeting-and-immunomodulatory-agents-a-guideline-by-the-american-society-for-radiation-oncology
#11
REVIEW
Robert G Bristow, Brian Alexander, Michael Baumann, Scott V Bratman, J Martin Brown, Kevin Camphausen, Peter Choyke, Deborah Citrin, Joseph N Contessa, Adam Dicker, David G Kirsch, Mechthild Krause, Quynh-Thu Le, Michael Milosevic, Zachary S Morris, Jann N Sarkaria, Paul M Sondel, Phuoc T Tran, George D Wilson, Henning Willers, Rebecca K S Wong, Paul M Harari
The practice of radiation oncology is primarily based on precise technical delivery of highly conformal, image-guided external beam radiotherapy or brachytherapy. However, systematic research efforts are being made to facilitate individualised radiation dose prescriptions on the basis of gene-expressssion profiles that reflect the radiosensitivity of tumour and normal tissue. This advance in precision radiotherapy should complement those benefits made in precision cancer medicine that use molecularly targeted agents and immunotherapies...
May 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29722340/role-of-recursive-partitioning-analysis-and-graded-prognostic-assessment-on-identifying-non-small-cell-lung-cancer-patients-with-brain-metastases-who-may-benefit-from-postradiation-systemic-therapy
#12
Shuai Liu, Peng Chen, Yan-Wei Liu, Xue-Nan Gu, Xiao-Guang Qiu, Bo Li
Background: The role of postradiation systemic therapy in non-small cell lung cancer (NSCLC) patients with brain metastasis (BM) was controversial. Thus, we explored the role of Radiation Therapy Oncology Group recursive partitioning analysis (RTOG-RPA) and graded prognostic assessment (GPA) in identifying population who may benefit from postradiation systemic therapy. Methods: The clinical data of NSCLC patients with documented BM from August 2007 to April 2015 of two hospitals were studied retrospectively...
May 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29714662/safety-of-concurrent-adjuvant-radiotherapy-and-chemotherapy-for-locally-advanced-soft-tissue-sarcoma
#13
Daniela Greto, Mauro Loi, Calogero Saieva, Cristina Muntoni, Camilla Delli Paoli, Carlotta Becherini, Cinzia Ciabatti, Marco Perna, Domenico Campanacci, Francesca Terziani, Giovanni Beltrami, Guido Scoccianti, Pierluigi Bonomo, Icro Meattini, Isacco Desideri, Gabriele Simontacchi, Monica Mangoni, Lorenzo Livi
INTRODUCTION: This retrospective study analyzes the safety and feasibility of concurrent chemoradiotherapy (CRT) in adjuvant treatment of soft tissue sarcoma (STS). METHODS: A total of 158 patients with STS were retrospectively analyzed. Anthracycline-based computed tomography was performed in high-risk patients. Acute radiotherapy toxicity and chemotherapy-related toxicity were assessed according to the Common Terminology Criteria for Adverse Events 4.0; late radiotherapy toxicity was recorded according to Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria...
April 1, 2018: Tumori
https://www.readbyqxmd.com/read/29697477/utility-scores-and-preferences-for-surgical-and-organ-sparing-approaches-for-treatment-of-intermediate-and-high-risk-rectal-cancer
#14
Alice M Couwenberg, Martijn P W Intven, Johannes P M Burbach, Marleen J Emaus, Wilhelmina M U van Grevenstein, Helena M Verkooijen
BACKGROUND: Organ-sparing approaches, including wait-and-see and local excision, are increasingly being offered to patients with rectal cancer following a good response to neoadjuvant therapy. Preferences regarding these treatment strategies are yet unknown. OBJECTIVE: This study aimed to determine the preferences and utility scores for rectal cancer treatment approaches. DESIGN: This is a cross-sectional study. SETTING: This study was conducted at the Radiation-Oncology Department of the University Medical Center Utrecht...
April 24, 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29694234/expanding-the-therapeutic-index-of-radiation-therapy-by-normal-tissue-protection
#15
Pierre Montay-Gruel, Lydia Meziani, Chakradhar Yakkala, Marie-Catherine Vozenin
Normal tissue damages induced by radiation therapy remain dose-limiting factors in Radiation Oncology and this is still true despite recent advances in treatment planning and delivery of image-guided radiation therapy. Additionally, as the number of long-term cancer survivors increases, unacceptable complications emerge and dramatically reduce the patients' quality of life. This means that patients and clinicians expect discovery of new options for the therapeutic management of radiation-induced complications...
April 25, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29692980/leveraging-national-cancer-institute-programmatic-collaboration-for-uterine-cervix-cancer-patient-accrual-in-puerto-rico
#16
Charles A Kunos, Holly A Massett, Annette Galassi, Joan L Walker, Marge J Good, Luis Báez Díaz, Worta McCaskill-Stevens
Women in the U.S. Commonwealth of Puerto Rico (PR) have a higher age-adjusted incidence rate for uterine cervix cancer than the U.S. mainland as well as substantial access and economic barriers to cancer care. The National Cancer Institute (NCI) funds a Minority/Underserved NCI Community Oncology Research Program in PR (PRNCORP) as part of a national network of community-based health-care systems to conduct multisite cancer clinical trials in diverse populations. Participation by the PRNCORP in NCI's uterine cervix cancer clinical trials, however, has remained limited...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29691075/estro-acrop-guideline-interstitial-multi-catheter-breast-brachytherapy-as-accelerated-partial-breast-irradiation-alone-or-as-boost-gec-estro-breast-cancer-working-group-practical-recommendations
#17
Vratislav Strnad, Tibor Major, Csaba Polgar, Michael Lotter, Jose-Luis Guinot, Cristina Gutierrez-Miguelez, Razvan Galalae, Erik Van Limbergen, Benjamin Guix, Peter Niehoff, Kristina Lössl, Jean-Michel Hannoun-Levi
PURPOSE: This consensus statement from the Breast Cancer Working Group of Groupe Européen de Curiethérapie of European Society for Radiotherapy and Oncology (GEC-ESTRO) aims at generating practical guidelines for multi-catheter image-guided brachytherapy in the conservative management of breast cancer patients used for either Accelerated Partial Breast Irradiation (APBI) or for a breast boost. METHODS: Recent advances in techniques of multi-catheter brachytherapy were summarized and all the relevant literature was reviewed by a panel of experts...
April 21, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29681500/moving-toward-uniform-and-evidence-based-practice-of-radiotherapy-for-management-of-cervical-cancer-in-ontario-canada
#18
Negin Shahid, Timothy Craig, Mary Westerland, Allison Ashworth, Michelle Ang, David D'Souza, Raxa Sankreacha, Anthony Fyles, Michael Milosevic, Iwa Kong
PURPOSE: To recognize the practice of radiotherapy for management of cervical cancer in Ontario, Canada, and to use the results of the survey to harmonize and standardize practice across the province. METHODS AND MATERIALS: An electronic survey (SurveyMonkey) was sent to all 14 provincial cancer centers by Cancer Care Ontario Gynecology Community of Practice (CoP) in 2013. The survey included 72 questions in four different categories: general/demographic, pretreatment assessment, external beam radiotherapy (EBRT), and brachytherapy (BT)...
April 19, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29678596/evaluation-of-acute-skin-toxicity-of-breast-radiotherapy-using-thermography-results-of-a-prospective-single-centre-trial
#19
O Maillot, N Leduc, V Atallah, P Escarmant, A Petit, S Belhomme, P Sargos, V Vinh-Hung
PURPOSE: Radiotherapy is a common adjuvant treatment of breast cancer. Acute radiation-induced dermatitis is a frequent side effect. We hypothesized whether it is possible to capture the increase of local temperature as a surrogate of the inflammatory state induced by radiotherapy. We designed a prospective, observational, single-centre study to acquire data on temperature rise in the treated breast during the course of radiotherapy, establish a possible association with the occurrence of dermatitis and investigate the predictive value of temperature increase in future occurrences of radiation-induced dermatitis...
April 17, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29674005/breast-cancer-cutaneous-metastases-mimicking-papilloma-cutis-lymphostatica-biopsy-to-avoid-pitfalls
#20
Giuseppe Giudice, Michelangelo Vestita, Fabio Robusto, Paolo Annoscia, Francesco Ciancio, Eleonora Nacchiero
INTRODUCTION: Secondary lymphedema is the most frequent long-term complication of axillary lymphadenectomy. It can result in complication as erysipelas, warts, Papilloma Cutis Lymphostatica (PCL), or angiosarcomas. Moreover, in women affected by breast cancer an accurate differential diagnosis among these conditions or complication related to radiation dermatitis or cutaneous metastasis is essential. PRESENTATION OF CASE: We report the case of a 60-year-old postmenopausal Caucasian woman affected by secondary lymphedema following complete mastectomy for breast cancer...
April 10, 2018: International Journal of Surgery Case Reports
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