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radiation oncology radiotherapy cancer

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https://www.readbyqxmd.com/read/28087132/practice-patterns-of-thoracic-radiotherapy-for-extensive-stage-small-cell-lung-cancer-survey-of-us-academic-thoracic-radiation-oncologists
#1
Carl M Post, Vivek Verma, Timur Mitin, Charles B Simone
PURPOSE: Despite the recent CREST trial demonstrating a survival benefit to thoracic radiotherapy (TRT) for patients with extensive-stage small-cell lung cancer (ES-SCLC) with response to chemotherapy, as well as endorsement by current National Comprehensive Cancer Network guidelines, TRT may not be uniformly delivered in clinical practice across all circumstances. METHODS AND MATERIALS: We surveyed US academic thoracic radiation oncologists regarding their practice patterns for TRT and assessed conditions in which withholding TRT could be warranted...
December 22, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28073946/a-randomized-phase-iii-trial-of-comparing-two-dose-fractionations-stereotactic-body-radiotherapy-sbrt-for-medically-inoperable-stage-ia-non-small-cell-lung-cancer-or-small-lung-lesions-clinically-diagnosed-as-primary-lung-cancer-japan-clinical-oncology-group
#2
EDITORIAL
Tomoki Kimura, Yasushi Nagata, Junko Eba, Shuichi Ozawa, Satoshi Ishikura, Taro Shibata, Yoshinori Ito, Masahiro Hiraoka, Yasumasa Nishimura
A randomized Phase III trial commenced in Japan in February 2016. Currently, 42 Gy in four fractions of stereotactic body radiotherapy prescribed at the D95% of the planning target volume, which is considered equal to the commonly used 48 Gy in four fractions at the isocenter using an old dose calculation algorithm, is the standard treatment in Japan for medically inoperable Stage IA non-small cell lung cancer and small lung lesions clinically diagnosed as primary lung cancer. This study aims to examine the superiority of 55 Gy in four fractions over 42 Gy in four fractions...
January 9, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28063191/salvage-high-intensity-focused-ultrasound-hifu-for-locally-recurrent-prostate-cancer-after-failed-radiation-therapy-multi-institutional-analysis-of-418-patients
#3
Sebastien Crouzet, Andreas Blana, Francois J Murat, Gilles Pasticier, Stephen C W Brown, Giario N Conti, Roman Ganzer, Olivier Chapet, Albert Gelet, Christian G Chaussy, Cary N Robertson, Stefan Thuroff, John F Ward
OBJECTIVE: To report the oncological outcome of Salvage high-intensity focused ultrasound (S-HIFU) for locally recurrent prostate cancer (PCa) following External Beam Radiotherapy (EBRT) from a multicenter database. MATERIALS AND METHODS: This retrospective study comprises patients from 9 centers with local recurrent disease following EBRT treated with S-HIFU from 1995 to 2009. Biochemical free survival rates (BFSR) was based on the "Phoenix" definition (nadir+2)...
January 7, 2017: BJU International
https://www.readbyqxmd.com/read/28049550/gec-estro-acrop-recommendations-for-performing-bladder-sparing-treatment-with-brachytherapy-for-muscle-invasive-bladder-carcinoma
#4
Bradley R Pieters, Elzbieta van der Steen-Banasik, Geert A Smits, Marisol De Brabandere, Alberto Bossi, Erik Van Limbergen
The standard treatment for muscle-invasive bladder cancer (MIBC) is a radical cystectomy with pelvic lymph node dissection with or without neoadjuvant chemotherapy. In selected cases a bladder sparing approach is possible, for example a limited surgical excision combined with external beam radiotherapy and brachytherapy. To perform brachytherapy flexible catheters have to be implanted in the bladder wall. The implantation is done either by the open retropubic approach or the endoscopic surgical approach. The largest experience for brachytherapy is with low-dose rate and pulsed-dose rate, although some short-term experience with high-dose rate is also reported...
December 31, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28048862/th-e-202-02-the-use-of-hypoxia-pet-imaging-for-radiotherapy
#5
J Humm
: PET/CT is a very important imaging tool in the management of oncology patients. PET/CT has been applied for treatment planning and response evaluation in radiation therapy. This educational session will discuss: 1. Pitfalls and remedies in PET/CT imaging for RT planning 2. The use of hypoxia PET imaging for radiotherapy 3. PET for tumor response evaluation The first presentation will address the issue of mis-registration between the CT and PET images in the thorax and the abdomen. We will discuss the challenges of respiratory gating and introduce an average CT technique to improve the registration for dose calculation and image-guidance in radiation therapy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048529/tu-h-campus-tep2-02-flash-irradiation-improves-the-therapeutic-index-following-gi-tract-irradiation
#6
E Schueler, S Trovati, G King, F Lartey, M Rafat, B Loo, P Maxim
PURPOSE: To investigate and characterize the radiobiological effectiveness of very high dose rate radiotherapy (FLASH) compared to conventional irradiation in an in vivo model. METHODS: The gastrointestinal (GI) tract of C57BL/6 mice were irradiated with doses ranging between 10 and 18 Gy using a custom stereotactic jig. A Varian Clinac 21EX was modified to allow dose rates ranging from 0.05 to 240 Gy/s at the position of the mirror. With the gantry at 180 degrees, the jig holding the individual animals was placed above the mirror to take advantage of the reduced source to target distance...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048417/th-e-202-00-pet-for-radiation-therapy
#7
Wei Lu
: PET/CT is a very important imaging tool in the management of oncology patients. PET/CT has been applied for treatment planning and response evaluation in radiation therapy. This educational session will discuss: 1. Pitfalls and remedies in PET/CT imaging for RT planning 2. The use of hypoxia PET imaging for radiotherapy 3. PET for tumor response evaluation The first presentation will address the issue of mis-registration between the CT and PET images in the thorax and the abdomen. We will discuss the challenges of respiratory gating and introduce an average CT technique to improve the registration for dose calculation and image-guidance in radiation therapy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048404/we-h-201-03-enthusiasm-and-generosity-of-spirit-necessitate-a-volunteering-structure-to-make-them-more-meaningful
#8
Y Pipman
: The desperate need for radiotherapy in low and mid-income countries (LMICs) has been well documented. Roughly 60 % of the worldwide incidence of cancer occurs in these resource-limited settings and the international community alongside governmental and non-profit agencies have begun publishing reports and seeking help from qualified volunteers. However, the focus of several reports has been on how dire the situation is and the magnitude of the problem, leaving most to feel overwhelmed and unsure as to how to help and why to get involved...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048211/th-e-202-03-pet-for-tumor-response-evaluation
#9
W Lu
: PET/CT is a very important imaging tool in the management of oncology patients. PET/CT has been applied for treatment planning and response evaluation in radiation therapy. This educational session will discuss: 1. Pitfalls and remedies in PET/CT imaging for RT planning 2. The use of hypoxia PET imaging for radiotherapy 3. PET for tumor response evaluation The first presentation will address the issue of mis-registration between the CT and PET images in the thorax and the abdomen. We will discuss the challenges of respiratory gating and introduce an average CT technique to improve the registration for dose calculation and image-guidance in radiation therapy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048189/su-f-j-209-quantification-of-image-guidance-benefit-in-image-guided-radiotherapy-of-cancers
#10
L Zhou, J Deng
PURPOSE: Image-guidance has been widely used in radiation oncology for accurate radiotherapy. The goal of this study is to quantify the benefit of image-guidance in image-guided radiotherapy (IGRT) of cancers. METHODS: In this study, a new index termed image-guidance benefit (IGB), was proposed to quantify the benefit of image-guidance in cancer radiotherapy. It is calculated as a ratio of the square sum of dose differences between planning dose matrix and actual delivery dose matrix post image-guidance to the square sum of dose summation between the two matrixes, summing over all dose scoring voxels...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047931/su-f-t-249-application-of-human-factors-methods-usability-testing-in-the-radiation-oncology-environment
#11
H Warkentin, K Bubric, H Giovannetti, G Graham, C Clay
PURPOSE: As a quality improvement measure, we undertook this work to incorporate usability testing into the implementation procedures for new electronic documents and forms used by four affiliated radiation therapy centers. METHODS: A human factors specialist provided training in usability testing for a team of medical physicists, radiation therapists, and radiation oncologists from four radiotherapy centers. A usability testing plan was then developed that included controlled scenarios and standardized forms for qualitative and quantitative feedback from participants, including patients...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047760/we-h-201-04-models-for-developing-medical-physics-educators-and-education-programs-in-the-developing-countries-and-the-potential-role-of-us-universities-and-individual-medical-physicists
#12
P Sprawls
: The desperate need for radiotherapy in low and mid-income countries (LMICs) has been well documented. Roughly 60 % of the worldwide incidence of cancer occurs in these resource-limited settings and the international community alongside governmental and non-profit agencies have begun publishing reports and seeking help from qualified volunteers. However, the focus of several reports has been on how dire the situation is and the magnitude of the problem, leaving most to feel overwhelmed and unsure as to how to help and why to get involved...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047638/su-f-p-09-a-global-medical-physics-collaboration-for-implementation-of-modern-radiotherapy-in-botswana
#13
R Makufa, M Bvochora-Nsingo, T Karumekayi, R J Schneider, J A Efstathiou, S Dryden-Peterson, A Odom, A Shulman, Y Pipman, D P Gierga
PURPOSE: The global burden of cancer is considerable, particularly in low and middle-income countries. Massachusetts General Hospital (MGH) and Botswana-Harvard AIDS Institute have partnered with the oncology community and government of Botswana to form BOTSOGO (BOTSwana Oncology Global Outreach) to address the rising burden of cancer in Botswana. Currently, radiation therapy (RT) is only available at a single linear accelerator (LINAC) in Gaborone Private Hospital (GPH). BOTSOGO worked to limit the absence of RT during a LINAC upgrade and ensure a safe transition to modern radiotherapy techniques...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047637/we-h-201-00-opportunities-for-physicists-to-support-low-and-mid-income-countries
#14
Julianne Pollard
: The desperate need for radiotherapy in low and mid-income countries (LMICs) has been well documented. Roughly 60 % of the worldwide incidence of cancer occurs in these resource-limited settings and the international community alongside governmental and non-profit agencies have begun publishing reports and seeking help from qualified volunteers. However, the focus of several reports has been on how dire the situation is and the magnitude of the problem, leaving most to feel overwhelmed and unsure as to how to help and why to get involved...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047249/su-f-t-351-establishing-a-workflow-for-imrt-pre-treatment-reviews-for-nrg-gy006-clinical-trial
#15
T Giaddui, N Li, K Curry, K Moore, L Mell, C Leath, C Kunos, Y Xiao
PURPOSE: To establish a workflow for NRG-GY006 IMRT pre-treatment reviews, incorporating advanced radiotherapy technologies being evaluated as part of the clinical trial. METHODS: Pre-Treatment reviews are required for every IMRT case as part of NRG-GY006 (a randomized phase II trial of radiation therapy and cisplatin alone or in combination with intravenous triapine in women with newly diagnosed bulky stage I B2, stage II, IIIB, or IVA cancer of the uterine cervix or stage II-IVA vaginal cancer...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046986/we-h-201-01-the-opportunities-and-benefits-of-helping-lmics-how-helping-them-can-help-you
#16
J Pollard
: The desperate need for radiotherapy in low and mid-income countries (LMICs) has been well documented. Roughly 60 % of the worldwide incidence of cancer occurs in these resource-limited settings and the international community alongside governmental and non-profit agencies have begun publishing reports and seeking help from qualified volunteers. However, the focus of several reports has been on how dire the situation is and the magnitude of the problem, leaving most to feel overwhelmed and unsure as to how to help and why to get involved...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046798/th-e-202-01-pitfalls-and-remedies-in-pet-ct-imaging-for-rt-planning
#17
T Pan
: PET/CT is a very important imaging tool in the management of oncology patients. PET/CT has been applied for treatment planning and response evaluation in radiation therapy. This educational session will discuss: 1. Pitfalls and remedies in PET/CT imaging for RT planning 2. The use of hypoxia PET imaging for radiotherapy 3. PET for tumor response evaluation The first presentation will address the issue of mis-registration between the CT and PET images in the thorax and the abdomen. We will discuss the challenges of respiratory gating and introduce an average CT technique to improve the registration for dose calculation and image-guidance in radiation therapy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046761/mo-g-201-01-a-multi-institutional-study-investigating-the-performance-of-a-knowledge-based-planning-system-against-pinnacle-auto-planning-engine-in-sib-imrt-for-the-head-and-neck-cancer
#18
B Wu, M Kusters, M Kunze-Busch, T Dijkema, T McNutt, G Sanguineti, D Pang
PURPOSE: Knowledge-based Planning (KBP) founded on prior planning experience and Auto-Planning Engine (APE; commercialized in Pinnacle v9.10 TPS) based on progressive optimization algorithm both aim to eliminate the trial-and-error process in radiotherapy inverse planning. This study investigates the performance of the approaches in a multi-institutional setting to evaluate their functionalities in oropharyngeal cancer and offers suggestions how they can be implemented in the clinic. METHODS: Radboud University Medical Center (RUMC) provided 35 oropharyngeal cancer patients (SIB-IMRT with two-dose-level prescription: 68 Gy to PTV68 and 50...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046721/su-f-t-100-development-and-implementation-of-a-treatment-planning-tracking-system-into-the-radiation-oncology-clinic
#19
C Kabat, K Cline, Y Li, C Ha, S Stathakis
PURPOSE: With increasing numbers of cancer patients being diagnosed and the complexity of radiotherapy treatments rising it's paramount that patient plan development continues to stay fluid within the clinic. In order to maintain a high standard of care and clinical efficiency the establishment of a tracking system for patient plan development allows healthcare providers to view real time plan progression and drive clinical workflow. In addition, it provides statistical datasets which can further identify inefficiencies within the clinic...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046697/su-f-j-203-retrospective-assessment-of-delivered-proton-dose-in-prostate-cancer-patients-based-on-daily-in-room-ct-imaging
#20
K Stuetzer, T Paessler, C Valentini, F Exner, J Thiele, T Hoelscher, M Krause, C Richter
PURPOSE: Retrospective calculation of the delivered proton dose in prostate cancer patients based on a unique dataset of daily CT images. METHODS: Inter-fractional motion in prostate cancer patients treated at our proton facility is counteracted by water-filled endorectal ballon and bladder filling protocol. Typical plans (XiO, Elekta Instruments AB, Stockholm) for 74 Gy(RBE) sequential boost treatment in 37 fractions include two series of opposing lateral double-scattered proton beams covering the respective iCTV...
June 2016: Medical Physics
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