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https://www.readbyqxmd.com/read/28739765/relationship-of-th17-treg-cells-and-radiation-pneumonia-in-locally-advanced-esophageal-carcinoma
#1
Yan Wang, Gang Xu, Jie Wang, Xin-Hua Li, Ping Sun, Wei Zhang, Jun-Xia Li, Chao-Yang Wu
BACKGROUND/AIM: Radiation pneumonia is a main side-effect that has limited the clinical usage of radiotherapy in locally advanced esophageal carcinoma. T helper cells 17 (Th 17) and T regulatory cells (Tregs) play an important role in inflammatory diseases. The balance between Treg and Th17 cells is a key factor in the progression of many inflammatory and autoimmune diseases. Whether Tregs and Th17 cells are predictive factors of radiation pneumonia has not yet been reported. In this study, we investigated the relationships of Treg/Th17 cells and radiation pneumonia in patients with locally advanced esophageal cancer who received radiotherapy...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28737100/laser-surgery-versus-radiotherapy-for-t1a-glottic-carcinoma-a-meta-analysis-of-oncologic-outcomes
#2
Guanjiang Huang, Mengsi Luo, Jingxuan Zhang, Hongbing Liu
OBJECTIVES: A meta-analysis was conducted to compare oncologic outcomes for patients of T1a glottic carcinoma who were treated with laser surgery (LS) or radiotherapy (RT). METHODS: All related studies published up to October 2016 were acquired by searching PubMed, EMBASE, and Cochrane were conducted by two authors, with the index words: vocal, glottis, larynx, laser, surgery, cordectomy, radiotherapy, radiation, irradiation, carcinoma, and cancer. Relative studies which compared oncologic outcomes between LS and RT were included...
July 24, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28735685/utilizing-circulating-tumour-dna-in-radiation-oncology
#3
REVIEW
Ariana Rostami, Scott V Bratman
Emerging technologies for detection of circulating tumour DNA (ctDNA) are expanding the possibilities for clinical impact to patients with localized, potentially curable cancer. For such patients, ctDNA analysis could aid in prognostication, prediction of treatment response, longitudinal monitoring for adaptive treatment, and evaluation of minimal residual disease. Radiation oncologists currently have few tools at their disposal for predicting or rapidly assessing treatment efficacy. By reflecting the genetic and epigenetic makeup of tumours as well as dynamic changes with treatment, ctDNA as a biomarker for radiation response could enable new personalized treatment approaches...
July 20, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28731537/frailty-and-cancer-implications-for-oncology-surgery-medical-oncology-and-radiation-oncology
#4
REVIEW
Cecilia G Ethun, Mehmet A Bilen, Ashesh B Jani, Shishir K Maithel, Kenneth Ogan, Viraj A Master
Answer questions and earn CME/CNE The concept of frailty has become increasingly recognized as one of the most important issues in health care and health outcomes and is of particular importance in patients with cancer who are receiving treatment with surgery, chemotherapy, and radiotherapy. Because both cancer itself, as well as the therapies offered, can be significant additional stressors that challenge a patient's physiologic reserve, the incidence of frailty in older patients with cancer is especially high-it is estimated that over one-half of older patients with cancer have frailty or prefrailty...
July 21, 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/28713771/integrating-hyperthermia-into-modern-radiation-oncology-what-evidence-is-necessary
#5
REVIEW
Jan C Peeken, Peter Vaupel, Stephanie E Combs
Hyperthermia (HT) is one of the hot topics that have been discussed over decades. However, it never made its way into primetime. The basic biological rationale of heat to enhance the effect of radiation, chemotherapeutic agents, and immunotherapy is evident. Preclinical work has confirmed this effect. HT may trigger changes in perfusion and oxygenation as well as inhibition of DNA repair mechanisms. Moreover, there is evidence for immune stimulation and the induction of systemic immune responses. Despite the increasing number of solid clinical studies, only few centers have included this adjuvant treatment into their repertoire...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28702770/oncologic-outcomes-after-treatment-for-mri-occult-breast-cancer-pt0n
#6
Damian P McCartan, Emily C Zabor, Monica Morrow, Kimberly J Van Zee, Mahmoud B El-Tamer
BACKGROUND: Studies assessing outcomes in occult breast cancer have often included women treated before the routine use of magnetic resonance imaging (MRI). This study examined outcomes for patients presenting with axillary adenopathy and no primary breast tumor detectable by MRI or other imaging methods. METHODS: All patients with axillary nodal metastases consistent with breast carcinoma and no breast primary tumor detectable by physical exam, mammography, or MRI treated between 1 January 1996 and 30 June 2011 were identified from an institutional database...
July 12, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28697786/spinal-bone-metastases-in-colorectal-cancer-a-retrospective-analysis-of-stability-prognostic-factors-and-survival-after-palliative-radiotherapy
#7
Tilman Bostel, Robert Förster, Ingmar Schlampp, Tania Sprave, Thomas Bruckner, Nils Henrik Nicolay, Stefan Ezechiel Welte, Jürgen Debus, Harald Rief
BACKGROUND: This retrospective analysis aimed to analyse the stability of spinal bone metastases in colorectal cancer (CRC) patients following radiotherapy (RT) by use of a validated score and to assess prognostic factors for stability and survival. METHODS: Ninety-four patients with osteolytic spinal bone metastases from CRC were treated at the Department of Radiation Oncology at the University Hospital Heidelberg between 2000 and 2014. The stability of each affected vertebral body was assessed according to the validated Taneichi bone stability score on the basis of the treatment planning CT scan prior to RT and also based on the follow-up CT examinations at 3 and 6 months after RT...
July 11, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28690104/a-clinical-perspective-on-regional-nodal-irradiation-for-breast-cancer
#8
Amy C Moreno, Simona F Shaitelman, Thomas A Buchholz
The goal of regional treatments in breast cancer should be to eradicate any disease within lymph nodes, avoid regional recurrences, minimize the risk of distant metastases, and improve survival. In addition, regional treatments should focus on reducing potential morbidities and optimizing the long-term quality of life of breast cancer survivors. While data from recent surgical and radiation trials have helped clarify many issues regarding regional treatment, there still remains controversy as to the optimal approach for patients with "intermediate risk" disease...
July 6, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28688020/salvage-therapy-options-for-local-prostate-cancer-recurrence-after-primary-radiotherapy-a-literature-review
#9
REVIEW
Nicole M Golbari, Aaron E Katz
PURPOSE OF REVIEW: While recurrence after primary treatment of prostate cancer (PCa) is not uncommon, there is currently no consensus on the most appropriate management after radiation treatment failure. This article seeks to explore the currently utilized modalities for salvage treatment for radiorecurrent PCa. We focused our review on the oncologic outcomes and reported toxicity rates in the latest studies examining salvage radical prostatectomy (SRP), salvage cryotherapy (SCT), salvage high-intensity focused ultrasound (HIFU) and re-irradiation...
August 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28687923/lapatinib-with-whole-brain-radiotherapy-in-patients-with-brain-metastases-from-breast-and-non-small-cell-lung-cancer-a-phase-ii-study-of-the-hellenic-cooperative-oncology-group-hecog
#10
Christos Christodoulou, Anna Kalogera-Fountzila, Vasilios Karavasilis, George Kouvatseas, Christos N Papandreou, Epaminontas Samantas, Kalliopi Varaki, Georgios Papadopoulos, Mattheos Bobos, Grigorios Rallis, Evangelia Razis, Athina Goudopoulou, Konstantine T Kalogeras, Konstantinos N Syrigos, George Fountzilas
Small molecules, mainly tyrosine kinase inhibitors, are currently used in various malignancies. Lapatinib, a dual inhibitor of EGFR/HER2 tyrosine kinases, has demonstrated effectiveness in brain metastases from HER2-overexpressing breast cancer. It also appears to sensitize EGFR-expressing cell lines to radiation. To evaluate the efficacy of lapatinib in combination with whole brain radiotherapy (WBRT) in patients with brain metastases from non-small cell lung cancer (NSCLC) and breast cancer, as assessed by volumetric analysis by MRI...
July 7, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28666551/european-organization-for-research-and-treatment-of-cancer-eortc-recommendations-for-planning-and-delivery-of-high-dose-high-precision-radiotherapy-for-lung-cancer
#11
Dirk De Ruysscher, Corinne Faivre-Finn, Ditte Moeller, Ursula Nestle, Coen W Hurkmans, Cécile Le Péchoux, José Belderbos, Matthias Guckenberger, Suresh Senan
PURPOSE: To update literature-based recommendations for techniques used in high-precision thoracic radiotherapy for lung cancer, in both routine practice and clinical trials. METHODS: A literature search was performed to identify published articles that were considered clinically relevant and practical to use. Recommendations were categorised under the following headings: patient positioning and immobilisation, Tumour and nodal changes, CT and FDG-PET imaging, target volumes definition, radiotherapy treatment planning and treatment delivery...
June 27, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28654633/chemotherapy-with-radiotherapy-influences-time-to-development-of-radiation-induced-sarcomas-a-multicenter-study
#12
A Y Zhang, I Judson, C Benson, J S Wunder, I Ray-Coquard, R J Grimer, R Quek, E Wong, A B Miah, P C Ferguson, A Dufresne, J Y H Teh, M Stockler, M H N Tattersall
BACKGROUND: An increasing number and proportion of cancer patients with apparently localised disease are treated with chemotherapy and radiation therapy in contemporary oncology practice. In a pilot study of radiation-induced sarcoma (RIS) patients, we demonstrated that chemotherapy was associated with a reduced time to development of RIS. We now present a multi-centre collaborative study to validate this association. METHODS: This was a retrospective cohort study of RIS cases across five large international sarcoma centres between 1 January 2000 to 31 December 2014...
July 25, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28648354/erratum-to-hypofractionated-radiotherapy-in-pancreatic-cancer-lessons-from-the-past-in-the-era-of-stereotactic-body-radiation-therapy-critical-reviews-in-oncology-hematology-103c-2016-49-61
#13
De Bari Berardino, Porta Laetitia, Mazzola Rosario, Alongi Filippo, Wagner Anna Dorothea, Schäfer Markus, Bourhis Jean, Ozsahin Mahmut
No abstract text is available yet for this article.
June 22, 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28643731/cardiotoxic-effects-of-radiotherapy-and-strategies-to-reduce-them-in-patients-with-breast-cancer-an-overview
#14
REVIEW
Katarzyna Rygiel
Cardiotoxicity of various anticancer therapies, including radiotherapy (RT), can lead to cardiovascular (CV) complications, and their severity depends on many factors, including the site of action, the applied dose, the method of administration, the presence of pre-existing CV diseases, or CV risk factors, the individual patient characteristics, and the current or previous use of antineoplastic therapies. Cardiotoxicity can occur immediately upon administration of the anticancer therapy or it may have a delayed onset (months or years after the treatment)...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28642008/concurrent-once-daily-versus-twice-daily-chemoradiotherapy-in-patients-with-limited-stage-small-cell-lung-cancer-convert-an-open-label-phase-3-randomised-superiority-trial
#15
Corinne Faivre-Finn, Michael Snee, Linda Ashcroft, Wiebke Appel, Fabrice Barlesi, Adityanarayan Bhatnagar, Andrea Bezjak, Felipe Cardenal, Pierre Fournel, Susan Harden, Cecile Le Pechoux, Rhona McMenemin, Nazia Mohammed, Mary O'Brien, Jason Pantarotto, Veerle Surmont, Jan P Van Meerbeeck, Penella J Woll, Paul Lorigan, Fiona Blackhall
BACKGROUND: Concurrent chemoradiotherapy is the standard of care in limited-stage small-cell lung cancer, but the optimal radiotherapy schedule and dose remains controversial. The aim of this study was to establish a standard chemoradiotherapy treatment regimen in limited-stage small-cell lung cancer. METHODS: The CONVERT trial was an open-label, phase 3, randomised superiority trial. We enrolled adult patients (aged ≥18 years) who had cytologically or histologically confirmed limited-stage small-cell lung cancer, Eastern Cooperative Oncology Group performance status of 0-2, and adequate pulmonary function...
June 19, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28626489/conference-report-on-the-indo-global-summit-on-head-and-neck-oncology-igshno-2017-bmcon-iv-24-26-february-2017-jaipur-india
#16
Tej Prakash Soni, Anil K Gupta, Lalit M Sharma, Pawan Singhal, Dinesh Yadav, Umesh Bansal
'The multidisciplinary approach: expanding treatment horizons for head and neck cancer' was the major theme of the Indo Global Summit on Head and Neck Oncology (IGSHNO 2017-BMCON-IV). The meeting, held in Jaipur (Rajasthan, India) from 24 to 26 February 2017, assembled 600 participants from India and worldwide. It was organised by the Bhagwan Mahaveer Cancer Hospital and Research Centre (BMCHRC), Jaipur. BMCHRC Jaipur is one of the largest superspeciality oncology research and treatment centres in north India...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28620815/radiation-related-toxicities-and-outcomes-in-endometrial-cancer-are-obese-women-at-a-disadvantage
#17
A Smits, J McGrane, A Lopes, E Kent, R Bekkers, L Massuger, N Simpson, K Galaal
OBJECTIVE: To assess the impact of body mass index (BMI) on radiotherapy toxicities in endometrial cancer patients. METHODS: This was a retrospective cohort study of women diagnosed with endometrial cancer between January 2006 and December 2014 at the Royal Cornwall Hospital Trust. Women who received radiotherapy as part of their treatment, including external beam radiotherapy (EBRT) and/or vaginal brachytherapy were included. Radiation-related toxicities were graded according to the Radiation Therapy Oncology Group (RTOG) guidelines...
June 15, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28611947/thirty-five-years-of-thyroid-cancer-experience-in-a-paediatric-population-incidence-trends-in-lithuania-between-1980-and-2014
#18
Rima Bėrontienė, Edita Jašinskienė, Rosita Kiudelienė, Gintaras Kuprionis, Jurgita Makštienė, Raminta Macaitytė, Dalia Marčiulionytė, Lina Poškienė, Agnė Šemetaitė, Vygantas Šidlauskas, Raimondas Valickas, Rimantas Žalinkevičius, Rasa Verkauskienė
BACKGROUND: Thyroid cancer (TC) is a rare condition in children. It may be associated with radiation, iodine deficiency or familial inheritance. AIMS: The objectives of this study were to analyse the prevalence and incidence trends over 3 decades and clinical features of TC in the paediatric population in Lithuania. METHODS: We reviewed all TC cases diagnosed in children aged less than 18 years during the period 1980-2014 using medical records from 3 main hospitals in Lithuania where such TC cases are managed...
February 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28610779/survival-and-complications-following-surgery-and-radiation-for-localized-prostate-cancer-an-international-collaborative-review
#19
REVIEW
Christopher J D Wallis, Adam Glaser, Jim C Hu, Hartwig Huland, Nathan Lawrentschuk, Daniel Moon, Declan G Murphy, Paul L Nguyen, Matthew J Resnick, Robert K Nam
BACKGROUND: Evaluation of treatment options for localized prostate cancer (PCa) remains among the highest priorities for comparative effectiveness research. Surgery and radiotherapy (RT) are the two interventions most commonly used. OBJECTIVE: To provide a critical narrative review of evidence of the comparative effectiveness and harms of surgery and RT in the treatment of localized PCa. EVIDENCE ACQUISITION: A collaborative critical narrative review of the literature was conducted...
June 10, 2017: European Urology
https://www.readbyqxmd.com/read/28608305/quality-assurance-of-the-preopanc-trial-2012-003181-40-for-preoperative-radiochemotherapy-in-pancreatic-cancer-the-dummy-run
#20
Eva Versteijne, Eelco Lens, Astrid van der Horst, Arjan Bel, Jorrit Visser, Cornelis J A Punt, Mustafa Suker, Casper H J van Eijck, Geertjan van Tienhoven
BACKGROUND: The Dutch Pancreatic Cancer Group initiated the national, multicentre, controlled PREOPANC trial, randomising between preoperative radiochemotherapy and direct explorative laparotomy for patients with (borderline) resectable pancreatic cancer. The aim of this dummy run is to evaluate compliance with the radiotherapy protocol of this trial, and the quality of delineation and radiation plans. METHODS: Eleven radiation oncology departments open for accrual of patients in the PREOPANC trial were provided with all necessary information of a selected 'dummy' patient...
June 12, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
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