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https://www.readbyqxmd.com/read/29103291/current-and-future-uses-of-transcranial-focused-ultrasound-in-neurosurgery
#1
David S Hersh, Howard M Eisenberg
Focused ultrasound (FUS) produces a region of high intensity at the focal zone of the beam but with minimal effects at adjacent areas, allowing the sonication of deep targets throughout the body. Despite early obstacles to transmitting ultrasound energy through the skull, recent advances in ultrasound technology, software, and real-time monitoring have resulted in a renewed interest in the clinical applications of transcranial FUS. Following extensive pre- clinical studies, ultrasound-induced thermal ablation has been approved by several countries for the treatment of essential tremor, Parkinson's disease, obsessive-compulsive disorder, depression, and neuropathic pain...
November 3, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29103031/transcranial-sonography-in%C3%A2-neurodegenerative-diseases-with-cognitive-decline
#2
Silvia Favaretto, Uwe Walter, Claudio Baracchini, Annachiara Cagnin
Transcranial sonography (TCS) of the brain parenchyma detects alterations in the substantia nigra (SN), raphe nuclei, and basal ganglia; this technique has been established as a tool for the early diagnosis of Parkinson's disease and differential diagnosis from atypical parkinsonian syndromes. Here, we aimed to review the main applications of TCS in neurodegenerative diseases presenting with dementia syndrome, focusing on Alzheimer's disease (AD), dementia with Lewy bodies (DLB), frontotemporal lobar degeneration, idiopathic normal pressure hydrocephalus, and atypical and secondary parkinsonisms...
November 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29071355/extent-of-dorsolateral-prefrontal-cortex-plasticity-and-its-association-with-working-memory-in-patients-with-alzheimer-disease
#3
Sanjeev Kumar, Reza Zomorrodi, Zaid Ghazala, Michelle S Goodman, Daniel M Blumberger, Amay Cheam, Corinne Fischer, Zafiris J Daskalakis, Benoit H Mulsant, Bruce G Pollock, Tarek K Rajji
Importance: The extent of dorsolateral prefrontal cortex (DLPFC) plasticity in Alzheimer disease (AD) and its association with working memory are not known. Objectives: To determine whether participants with AD had impaired DLPFC plasticity compared with healthy control participants, to compare working memory between participants with AD and controls, and to determine whether DLPFC plasticity was associated with working memory. Design, Setting, and Participants: This cross-sectional study included 32 participants with AD who were 65 years or older and met diagnostic criteria for dementia due to probable AD with a score of at least 17 on the Mini-Mental State Examination and 16 age-matched control participants...
October 25, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29067352/combined-mnemonic-strategy-training-and-high-definition-transcranial-direct-current-stimulation-for-memory-deficits-in-mild-cognitive-impairment
#4
Benjamin M Hampstead, Krishnankutty Sathian, Marom Bikson, Anthony Y Stringer
INTRODUCTION: Memory deficits characterize Alzheimer's dementia and the clinical precursor stage known as mild cognitive impairment. Nonpharmacologic interventions hold promise for enhancing functioning in these patients, potentially delaying functional impairment that denotes transition to dementia. Previous findings revealed that mnemonic strategy training (MST) enhances long-term retention of trained stimuli and is accompanied by increased blood oxygen level-dependent signal in the lateral frontal and parietal cortices as well as in the hippocampus...
September 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29067331/inferior-parietal-transcranial-direct-current-stimulation-with-training-improves-cognition-in-anomic-alzheimer-s-disease-and-frontotemporal-dementia
#5
Carlos Roncero, Heike Kniefel, Erik Service, Alexander Thiel, Stephan Probst, Howard Chertkow
INTRODUCTION: We evaluated whether transcranial direct current stimulation (tDCS) can improve picture-naming abilities in subjects with anomic Alzheimer or frontotemporal dementias. METHODS: Using a double-blind crossover design, 10 participants were trained on picture naming over a series of 10 sessions with either 30 minutes of anodal (2 mA) tDCS stimulation to the left inferior parieto-temporal region (P3) or sham stimulation. We evaluated performance on a trained picture-naming list, an equivalent untrained list, and additional neuropsychological tasks...
June 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29062035/csf-tau-is-associated-with-impaired-cortical-plasticity-cognitive-decline-and-astrocyte-survival-only-in-apoe4-positive-alzheimer-s-disease
#6
Giacomo Koch, Francesco Di Lorenzo, Stefano Loizzo, Caterina Motta, Sara Travaglione, Monica Baiula, Roberto Rimondini, Viviana Ponzo, Sonia Bonnì, Sofia Toniolo, Fabrizio Sallustio, Marco Bozzali, Carlo Caltagirone, Gabriele Campana, Alessandro Martorana
In Alzheimer's disease (AD) patients, apopoliprotein (APOE) polymorphism is the main genetic factor associated with more aggressive clinical course. However, the interaction between cerebrospinal fluid (CSF) tau protein levels and APOE genotype has been scarcely investigated. A possible key mechanism invokes the dysfunction of synaptic plasticity. We investigated how CSF tau interacts with APOE genotype in AD patients. We firstly explored whether CSF tau levels and APOE genotype influence disease progression and long-term potentiation (LTP)-like cortical plasticity as measured by transcranial magnetic stimulation (TMS) in AD patients...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29056365/computational-human-head-models-of-tdcs-influence-of-brain-atrophy-on-current-density-distribution
#7
Shirin Mahdavi, Farzad Towhidkhah
Despite increasing attention to the application of transcranial Direct Current Stimulation (tDCS) for enhancing cognitive functions in subjects exposing to varying degree of cerebral atrophy such as Alzheimer's disease (AD), aging, and mild cognitive impairment (MCI), there is no general information for customizing stimulation protocol. OBJECTIVE: The objective of this study is to examine how cerebral shrinkage associated with cognitive impairment and aging can perturb current density distribution through the brain...
September 28, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29043928/using-transcranial-direct-current-stimulation-to-treat-symptoms-in-mild-cognitive-impairment-and-alzheimer-s-disease
#8
Celina S Liu, Allison Rau, Damien Gallagher, Tarek K Rajji, Krista L Lanctôt, Nathan Herrmann
Transcranial direct current stimulation (tDCS) has recently been investigated as a potential nonpharmacological treatment for individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD). A comprehensive literature search was performed on tDCS studies published until March 2017 using MEDLINE, Embase and PsychINFO databases. 12 articles with a total of 202 MCI or AD participants were included. Although ten of the 12 studies demonstrated positive findings with tDCS, two studies reported no effect on cognition...
October 18, 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/28971775/beyond-the-therapeutic-effect-of-rtms-in-alzheimer-s-disease-a-possible-neuroprotective-role-of-hippocampal-bdnf-a-minireview
#9
Burak Yulug, Lütfü Hanoglu, Elmir Ksanmemmedov, Ozge Arıcı Düz, Burcu Polat, Taha Hanoglu, Mehmet Yalçin Günal, Ertugrul Kilic
There are limited studies in the literature evaluating region specific neuroprotective effects of repetitive transcranial magnetic stimulation (rTMS) in Alzheimer's Disease. Here, we aimed to review the neurochemical correlates of the hippocampal neuroprotective effect of rTMS in various preclinical and clinical studies. Our findings indicate that rTMS may exert a significant neuroprotective effect through acting on the hippocampal Brain Derived Growth Factor (BDNF) levels which may, in turn, slow the progression of Alzheimer's Disease...
September 27, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28955219/low-frequency-repetitive-transcranial-magnetic-stimulation-ameliorates-cognitive-function-and-synaptic-plasticity-in-app23-ps45-mouse-model-of-alzheimer-s-disease
#10
Zhilin Huang, Tao Tan, Yehong Du, Long Chen, Min Fu, Yanzhi Yu, Lu Zhang, Weihong Song, Zhifang Dong
Alzheimer's disease (AD) is a chronic neurodegenerative disease leading to dementia, which is characterized by progressive memory loss and other cognitive dysfunctions. Recent studies have attested that noninvasive repetitive transcranial magnetic stimulation (rTMS) may help improve cognitive function in patients with AD. However, the majority of these studies have focused on the effects of high-frequency rTMS on cognitive function, and little is known about low-frequency rTMS in AD treatment. Furthermore, the potential mechanisms of rTMS on the improvement of learning and memory also remain poorly understood...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28871222/reproducibility-of-single-pulse-paired-pulse-and-intermittent-theta-burst-tms-measures-in-healthy-aging-type-2-diabetes-and-alzheimer-s-disease
#11
Peter J Fried, Ali Jannati, Paula Davila-Pérez, Alvaro Pascual-Leone
Background: Transcranial magnetic stimulation (TMS) can be used to assess neurophysiology and the mechanisms of cortical brain plasticity in humans in vivo. As the use of these measures in specific populations (e.g., Alzheimer's disease; AD) increases, it is critical to understand their reproducibility (i.e., test-retest reliability) in the populations of interest. Objective: Reproducibility of TMS measures was evaluated in older adults, including healthy, AD, and Type-2 diabetes mellitus (T2DM) groups. Methods: Participants received two identical neurophysiological assessments within a year including motor thresholds, baseline motor evoked potentials (MEPs), short- and long-interval intracortical inhibition (SICI, LICI) and intracortical facilitation (ICF), and MEP changes following intermittent theta-burst stimulation (iTBS)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28766896/novel-cranial-implants-of-yttria-stabilized-zirconia-as-acoustic-windows-for-ultrasonic-brain-therapy
#12
Mario I Gutierrez, Elias H Penilla, Lorenzo Leija, Arturo Vera, Javier E Garay, Guillermo Aguilar
Therapeutic ultrasound can induce changes in tissues by means of thermal and nonthermal effects. It is proposed for treatment of some brain pathologies such as Alzheimer's, Parkinson's, Huntington's diseases, and cancer. However, cranium highly absorbs ultrasound reducing transmission efficiency. There are clinical applications of transcranial focused ultrasound and implantable ultrasound transducers proposed to address this problem. In this paper, biocompatible materials are proposed for replacing part of the cranium (cranial implants) based on low porosity polycrystalline 8 mol% yttria-stabilized-zirconia (8YSZ) ceramics as acoustic windows for brain therapy...
August 2, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28747446/transcranial-magnetic-stimulation-distinguishes-alzheimer-disease-from-frontotemporal-dementia
#13
Alberto Benussi, Francesco Di Lorenzo, Valentina Dell'Era, Maura Cosseddu, Antonella Alberici, Salvatore Caratozzolo, Maria Sofia Cotelli, Anna Micheli, Luca Rozzini, Alessandro Depari, Alessandra Flammini, Viviana Ponzo, Alessandro Martorana, Carlo Caltagirone, Alessandro Padovani, Giacomo Koch, Barbara Borroni
OBJECTIVE: To determine whether a transcranial magnetic stimulation (TMS) multiparadigm approach can be used to distinguish Alzheimer disease (AD) from frontotemporal dementia (FTD). METHODS: Paired-pulse TMS was used to investigate short-interval intracortical inhibition (SICI) and facilitation (ICF), long-interval intracortical inhibition, and short-latency afferent inhibition (SAI) to measure the activity of different intracortical circuits in patients with AD, patients with FTD, and healthy controls (HC)...
August 15, 2017: Neurology
https://www.readbyqxmd.com/read/28637840/promoting-sleep-oscillations-and-their-functional-coupling-by-transcranial-stimulation-enhances-memory-consolidation-in-mild-cognitive-impairment
#14
REVIEW
Julia Ladenbauer, Josef Ladenbauer, Nadine Külzow, Rebecca de Boor, Elena Avramova, Ulrike Grittner, Agnes Flöel
Alzheimer's disease (AD) not only involves loss of memory functions, but also prominent deterioration of sleep physiology, which is already evident at the stage of mild cognitive impairment (MCI). Cortical slow oscillations (SO; 0.5-1 Hz) and thalamocortical spindle activity (12-15 Hz) during sleep, and their temporal coordination, are considered critical for memory formation. We investigated the potential of slow oscillatory transcranial direct current stimulation (so-tDCS), applied during a daytime nap in a sleep-state-dependent manner, to modulate these activity patterns and sleep-related memory consolidation in nine male and seven female human patients with MCI...
July 26, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28629447/transcranial-direct-current-stimulation-for-depression-in-alzheimer-s-disease-study-protocol-for-a-randomized-controlled-trial
#15
Zui Narita, Yuma Yokoi
BACKGROUND: Patients with Alzheimer's disease frequently elicit neuropsychiatric symptoms as well as cognitive deficits. Above all, depression is one of the most common neuropsychiatric symptoms in Alzheimer's disease but antidepressant drugs have not shown significant beneficial effects on it. Moreover, electroconvulsive therapy has not ensured its safety for potential severe adverse events although it does show beneficial clinical effect. Transcranial direct current stimulation can be the safe alternative of neuromodulation, which applies weak direct electrical current to the brain...
June 19, 2017: Trials
https://www.readbyqxmd.com/read/28593105/photobiomodulation-with-near-infrared-light-helmet-in-a-pilot-placebo-controlled-clinical-trial-in-dementia-patients-testing-memory-and-cognition
#16
Marvin H Berman, James P Halper, Trent W Nichols, H Jarrett, Alan Lundy, Jason H Huang
Alzheimer's disease (AD) is a common, chronic expensive debilitating neurodegenerative disease with no current treatments to prevent the physical deterioration of the brain and the consequent cognitive deficits. The current pathophysiology of Alzheimer's disease is the accumulation of neurofibrillary tangles (NFTs) of hyperphosphorylated tau protein and amyloid-beta (Aβ) plaques. Antibody therapy of Tau and Amyloid beta, vaccines and other methods to decrease Tau and or Amyloid have not been successful after considerable pharmaceutical and biotech efforts...
2017: Journal of neurology and neuroscience
https://www.readbyqxmd.com/read/28580093/photobiomodulation-and-the-brain-a-new-paradigm
#17
Madison Hennessy, Michael R Hamblin
Transcranial photobiomodulation (PBM) also known as low level laser therapy (tLLLT) relies on the use of red/NIR light to stimulate, preserve and regenerate cells and tissues. The mechanism of action involves photon absorption in the mitochondria (cytochrome c oxidase), and ion channels in cells leading to activation of signaling pathways, up-regulation of transcription factors, and increased expression of protective genes. We have studied PBM for treating traumatic brain injury (TBI) in mice using a NIR laser spot delivered to the head...
January 2017: Journal of Optics
https://www.readbyqxmd.com/read/28559805/semantic-feature-training-in-combination-with-transcranial-direct-current-stimulation-tdcs-for-progressive-anomia
#18
Jinyi Hung, Ashley Bauer, Murray Grossman, Roy H Hamilton, H B Coslett, Jamie Reilly
We examined the effectiveness of a 2-week regimen of a semantic feature training in combination with transcranial direct current stimulation (tDCS) for progressive naming impairment associated with primary progressive aphasia (N = 4) or early onset Alzheimer's Disease (N = 1). Patients received a 2-week regimen (10 sessions) of anodal tDCS delivered over the left temporoparietal cortex while completing a language therapy that consisted of repeated naming and semantic feature generation. Therapy targets consisted of familiar people, household items, clothes, foods, places, hygiene implements, and activities...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28539894/modulation-of-brain-activity-with-noninvasive-transcranial-direct-current-stimulation-tdcs-clinical-applications-and-safety-concerns
#19
REVIEW
Haichao Zhao, Lei Qiao, Dongqiong Fan, Shuyue Zhang, Ofir Turel, Yonghui Li, Jun Li, Gui Xue, Antao Chen, Qinghua He
Transcranial direct current stimulation (tDCS) is a widely-used tool to induce neuroplasticity and modulate cortical function by applying weak direct current over the scalp. In this review, we first introduce the underlying mechanism of action, the brief history from discovery to clinical scientific research, electrode positioning and montages, and parameter setup of tDCS. Then, we review tDCS application in clinical samples including people with drug addiction, major depression disorder, Alzheimer's disease, as well as in children...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28505975/reduced-cardiovascular-functions-in%C3%A2-patients-with-alzheimer-s-disease
#20
Wang-Sheng Jin, Xian-Le Bu, Ye-Ran Wang, Ling Li, Wei-Wei Li, Yu-Hui Liu, Chi Zhu, Xiu-Qing Yao, Yang Chen, Chang-Yue Gao, Tao Zhang, Hua-Dong Zhou, Fan Zeng, Yan-Jiang Wang
Previous studies have suggested that cardiovascular functions might play a critical role in Alzheimer's disease (AD) pathogenesis. However, the relationship among heart function, blood flow of cerebral vessels, and AD remains unclear. In the present study, AD patients (n = 34) and age- and gender-matched cognitively normal controls (n = 34) were recruited. Demographic and comorbidity information was collected. The ejection fraction was measured using echocardiography, and the mean velocity, pulsatility index (PI), and resistance index (RI) of the basilar artery (BA), left terminal internal carotid artery (LTICA), and right terminal internal carotid artery (RTICA) were measured using transcranial Doppler...
2017: Journal of Alzheimer's Disease: JAD
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