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comparison of effects of equimolar doses of mannitol and hypertonic saline

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https://www.readbyqxmd.com/read/25929908/comparison-of-equimolar-doses-of-mannitol-and-hypertonic-saline-for-the-treatment-of-elevated-intracranial-pressure-after-traumatic-brain-injury-a-systematic-review-and-meta-analysis
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Min Li, Tao Chen, Shu-da Chen, Jing Cai, Ying-Hong Hu
The purpose of this meta-analysis was to compare the effectiveness of mannitol and hypertonic saline for reducing intracranial pressure (ICP) after traumatic brain injury (TBI).PubMed, Cochrane, Embase, and ISI Web of Knowledge databases were searched until July 3, 2014 using the terms intracranial hypertension, mannitol, and hypertonic saline. Randomized controlled trials and 2-arm prospective studies in which elevated ICP was present after TBI treated with mannitol or hypertonic saline were included. The primary outcome was the change of ICP from baseline to termination of the infusion, while the secondary outcomes were change from baseline to 30, 60, and 120 minutes after terminating the infusion and change of osmolarity from baseline to termination...
May 2015: Medicine (Baltimore)
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