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https://www.readbyqxmd.com/read/29163414/control-of-antimicrobial-resistance-requires-an-ethical-approach
#1
REVIEW
Ben Parsonage, Philip K Hagglund, Lloyd Keogh, Nick Wheelhouse, Richard E Brown, Stephanie J Dancer
Ethical behavior encompasses actions that benefit both self and society. This means that tackling antimicrobial resistance (AMR) becomes an ethical obligation, because the prospect of declining anti-infectives affects everyone. Without preventive action, loss of drugs that have saved lives over the past century, will condemn ourselves, people we know, and people we don't know, to unacceptable risk of untreatable infection. Policies aimed at extending antimicrobial life should be considered within an ethical framework, in order to balance the choice, range, and quality of drugs against stewardship activities...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29151327/serum-matrix-metalloproteinase-1-level-represents-disease-activity-as-opposed-to-fibrosis-in-patients-with-histologically-proven-nonalcoholic-steatohepatitis
#2
Wataru Ando, Hiroaki Yokomori, Nobuhiro Tsutsui, Eigoro Yamanouchi, Yutaka Suzuki, Masaya Oda, Yutaka Inagaki, Katsuya Otori, Isao Okazaki
Background/Aims: Nonalcoholic steatohepatitis (NASH) is prevalent in both economically developed and developing countries. Twenty percent of NASH progresses to cirrhosis with/without hepatocellular carcinoma, and there is an urgent need to find biomarkers for early diagnosis and monitoring progression of the disease. Using immunohistochemical and immunoelectron microscopic examination we previously reported that expression of matrix metalloproteinase-1 (MMP-1) increased in monocytes, Kupffer cells and hepatic stellate cells in early stage NASH...
November 20, 2017: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29150108/economy-class-syndrome-what-is-it-and-who-are-the-individuals-at-risk
#3
Luci Maria SantAna Dusse, Marcos Vinícius Ferreira Silva, Letícia Gonçalves Freitas, Milena Soriano Marcolino, Maria das Graças Carvalho
The term 'economy class syndrome' refers to the occurrence of thrombotic events during long-haul flights that mainly occur in passengers in the economy class of the aircraft. This syndrome results from several factors related to the aircraft cabin (immobilization, hypobaric hypoxia and low humidity) and the passenger (body mass index, thrombophilia, oral contraceptives or hormone replacement therapy, cancer), acting together to predispose to excessive blood coagulation, which can result in venous thromboembolism...
October 2017: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/29149162/-switching-from-one-drug-therapy-to-another-with-the-same-therapeutic-indication-without-harms
#4
Valeria Belleudi, Antonio Addis
The loss of exclusivity from several drug therapies largely used bring new attention the issues of safety, efficacy and following the switch from one drug to another (i.e., biosimilar and/or generics) with the same indication. This is not a problem that can be related to regulatory or economical factors. The increase of patients exposed to chronic conditions and the introductions or more pharmaceutical alternatives with same therapeutic indications yield for studies able to verify the effectiveness and safety even when switch from more drugs is considered by practitioners...
November 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29133873/coordinative-alignment-of-chiral-molecules-to-control-over-the-chirality-transfer-in-spontaneous-resolution-and-asymmetric-catalysis
#5
Zhengqiang Xia, Xu Jing, Cheng He, Xiaoge Wang, Chunying Duan
The production and availability of enantiomerically pure compounds that spurred the development of chiral technologies and materials are very important to the fine chemicals and pharmaceutical industries. By coordinative alignment of enantiopure guests in the metal‒organic frameworks, we reported an approach to control over the chirality of homochiral crystallization and asymmetric transformation. Synthesized by achiral triphenylamine derivatives, the chirality of silver frameworks was determined by the encapsulated enantiopure azomethine ylides, from which clear interaction patterns were observed to explore the chiral induction principles...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29121326/individualized-versus-standard-fsh-dosing-in-women-starting-ivf-icsi-an-rct-part-1-the-predicted-poor-responder
#6
Theodora C van Tilborg, Helen L Torrance, Simone C Oudshoorn, Marinus J C Eijkemans, Carolien A M Koks, Harold R Verhoeve, Annemiek W Nap, Gabrielle J Scheffer, A Petra Manger, Benedictus C Schoot, Alexander V Sluijmer, Arie Verhoeff, Henk Groen, Joop S E Laven, Ben Willem J Mol, Frank J M Broekmans
STUDY QUESTION: Does an increased FSH dose result in higher cumulative live birth rates in women with a predicted poor ovarian response, apparent from a low antral follicle count (AFC), scheduled for IVF or ICSI? SUMMARY ANSWER: In women with a predicted poor ovarian response (AFC < 11) undergoing IVF/ICSI, an increased FSH dose (225/450 IU/day) does not improve cumulative live birth rates as compared to a standard dose (150 IU/day). WHAT IS KNOWN ALREADY: In women scheduled for IVF/ICSI, an ovarian reserve test (ORT) can predict ovarian response to stimulation...
November 7, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29121269/individualized-versus-standard-fsh-dosing-in-women-starting-ivf-icsi-an-rct-part-2-the-predicted-hyper-responder
#7
Simone C Oudshoorn, Theodora C van Tilborg, Marinus J C Eijkemans, G Jur E Oosterhuis, Jaap Friederich, Marcel H A van Hooff, Evert J P van Santbrink, Egbert A Brinkhuis, Jesper M J Smeenk, Janet Kwee, Corry H de Koning, Henk Groen, Cornelis B Lambalk, Ben Willem J Mol, Frank J M Broekmans, Helen L Torrance
STUDY QUESTION: Does a reduced FSH dose in women with a predicted hyper response, apparent from a high antral follicle count (AFC), who are scheduled for IVF/ICSI lead to a different outcome with respect to cumulative live birth rate and safety? SUMMARY ANSWER: Although in women with a predicted hyper response (AFC > 15) undergoing IVF/ICSI a reduced FSH dose (100 IU per day) results in similar cumulative live birth rates and a lower occurrence of any grade of ovarian hyperstimulation syndrome (OHSS) as compared to a standard dose (150 IU/day), a higher first cycle cancellation rate and similar severe OHSS rate were observed...
November 7, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29104024/abortion-in-two-francophone-african-countries-a-study-of-whether-women-have-begun-to-use-misoprostol-in-benin-and-burkina-faso
#8
Carine Baxerres, Ines Boko, Adjara Konkobo, Fatoumata Ouattara, Agnès Guillaume
OBJECTIVES: This study aimed to document the means women use to obtain abortions in the capital cities of Benin and Burkina Faso, and to learn whether or not use of misoprostol has become an alternative to other methods of abortion, and the implications for future practice. STUDY DESIGN: We conducted in-depth, qualitative interviews between 2014 and 2015 with 34 women - 21 women in Cotonou (Benin) and 13 women in Ouagadougou (Burkina Faso) - about their pathways to abortion...
November 3, 2017: Contraception
https://www.readbyqxmd.com/read/29102705/a-laminin-receptor-like-protein-regulates-white-spot-syndrome-virus-infection-by-binding-to-the-viral-envelope-protein-vp28-in-red-claw-crayfish-cherax-quadricarinatus
#9
Ling-Ke Liu, Wei-Dong Li, Yan Gao, Rong-Yuan Chen, Xiao-Lu Xie, Heng Hong, Ke-Jian Wang, Hai-Peng Liu
White spot syndrome virus (WSSV) is a lethal pathogen of shrimp and many other crustaceans, which has been causing huge economic losses in global aquaculture. Laminin receptor (LR) is a cell surface receptor which participates in the interactions between cells as well as cells and extracellular matrix. Previously, we found that a CqLR-like gene was responsive to WSSV infection in the hematopoietic tissue (Hpt) cells from red claw crayfish Cherax quadricarinatus. To further reveal the role of CqLR-like gene involved in WSSV infection, the full-length cDNA of CqLR-like gene was cloned with 1000 bp, and the open reading frame encoded 308 amino acids with a conserved laminin-binding domain...
November 1, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29098813/-industrialization-condition-and-development-strategy-of-notopterygii-rhizoma-et-radix
#10
Shun-Yuan Jiang, Hui Sun, Hong-Lan Wang, Xiao-Jun Ma, Ji-Hong Qin, Jun Xin, Hong-Bing Sun, Jiu-Zhen Du, Li Yin
Notopterygii Rhizoma et Radix, the underground part of Notopterygium incisum and N. franchetii, is used as a classical traditional Chinese medicine, and as raw materials for 262 Chinese patent drugs production in 694 pharmaceutical factories currently. It plays an important role in the whole Chinese medicine industry with irreplaceable important economic and social values. However, wild resource of was abruptly depleted, and large-scale artificial cultivation has been inapplicable. In this study, Utilization history and the industrialization status of Notopterygii Rhizoma et Radix were summarized...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29089600/incentivising-innovation-in-antibiotic-drug-discovery-and-development-progress-challenges-and-next-steps
#11
REVIEW
Victoria L Simpkin, Matthew J Renwick, Ruth Kelly, Elias Mossialos
Political momentum and funding for combatting antimicrobial resistance (AMR) continues to build. Numerous major international and national initiatives aimed at financially incentivising the research and development (R&D) of antibiotics have been implemented. However, it remains unclear how to effectively strengthen the current set of incentive programmes to further accelerate antibiotic innovation. Based on a literature review and expert input, this study first identifies and assesses the major international, European Union, US and UK antibiotic R&D funding programmes...
November 1, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/29083342/the-pharmaceutical-care-and-the-rejected-constitutional-reform-what-might-have-been-and-what-is
#12
Margherita Siracusa, Iolanda Grappasonni, Fabio Petrelli
This study analyzes the current state of legislation pertaining to pharmaceutical/health care in a period of normative ferment characterized by continuous changes, after countless discussions that have been held on a proposed constitutional reform (rejected by the will of the people at the end of 2016). After a general reflection on the division of legislative powers between the State and its Regions, in the light of attempts to bring about a reform, we will analyse specific problems: from the recent, but in some ways already defined as historic, approval of the new Essential Levels of Care (LEC), the approval of the 2017 Budget Law (concerning important items such as the purchase of drugs), until we reach the Draft Law on competition which is in the process of being approved...
October 23, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29081920/the-perverse-impact-of-external-reference-pricing-erp-a-comparison-of-orphan-drugs-affordability-in-12-european-countries-a-call-for-policy-change
#13
K E Young, I Soussi, M Toumi
Objective: The study compared the relative cost differences of similar orphan drugs among high and low GDP countries in Europe: Bulgaria, France, Germany, Greece, Hungary, Italy, Norway, Poland, Romania, Spain, Sweden, UK. Methods: Annual treatment costs per patient were calculated. Relative costs were computed by dividing the costs by each economic parameter: nominal GDP per capita, GDP in PPP per capita, % GDP contributed by the government, government budget per inhabitant, % GDP spent on healthcare, % GDP spent on pharmaceuticals, and average annual salary...
2017: Journal of Market Access & Health Policy
https://www.readbyqxmd.com/read/29075325/rhodosporidium-toruloides-a-new-platform-organism-for-conversion-of-lignocellulose-into-terpene-biofuels-and-bioproducts
#14
Junko Yaegashi, James Kirby, Masakazu Ito, Jian Sun, Tanmoy Dutta, Mona Mirsiaghi, Eric R Sundstrom, Alberto Rodriguez, Edward Baidoo, Deepti Tanjore, Todd Pray, Kenneth Sale, Seema Singh, Jay D Keasling, Blake A Simmons, Steven W Singer, Jon K Magnuson, Adam P Arkin, Jeffrey M Skerker, John M Gladden
BACKGROUND: Economical conversion of lignocellulosic biomass into biofuels and bioproducts is central to the establishment of a robust bioeconomy. This requires a conversion host that is able to both efficiently assimilate the major lignocellulose-derived carbon sources and divert their metabolites toward specific bioproducts. RESULTS: In this study, the carotenogenic yeast Rhodosporidium toruloides was examined for its ability to convert lignocellulose into two non-native sesquiterpenes with biofuel (bisabolene) and pharmaceutical (amorphadiene) applications...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29073983/drug-policy-in-poland
#15
Karina Jahnz-Różyk, Pawel Kawalec, Krzysztof Malinowski, Katarzyna Czok
We presented a general overview of the health care system as well as the pricing and reimbursement environment in Poland. Poland aims to ensure proper access to safe and effective medicines while reducing patients' share in treatment costs. Nevertheless, the co-payment for pharmacotherapy is still high (more than 60%). The key policymaker and regulator in the system is the Ministry of Health, which is supported by the Polish Agency for Health Technology Assessment and Tariff System (Agencja Oceny Technologii Medycznych i Taryfikacji), responsible for evaluating applicant drugs, and the Economic Commission, responsible for negotiating the official sales prices and conditions for reimbursement with pharmaceutical companies (e...
September 2017: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29070050/potential-barriers-in-healthcare-access-of-the-elderly-population-influenced-by-the-economic-crisis-and-the-troika-agreement-a-qualitative-case-study-in-lisbon-portugal
#16
Julia Doetsch, Eva Pilot, Paula Santana, Thomas Krafft
BACKGROUND: The recent economic and financial crisis in Portugal urged the Portuguese Government in April 2011 to request financial assistance from the troika austerity bail out program to get aid for its government debt. The troika agreement included health reforms and austerity measures of the National Health Service (NHS) in Portugal to save non-essential health care costs. This research aimed to identify potential barriers among the elderly population (aged 65 and above) to healthcare access influenced by the economic crisis and the troika agreement focussing on the Memorandum of Understanding on Specific Economic Policy Conditionality (MoU) in Lisbon metropolitan area, Portugal...
October 25, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29068825/the-economic-burden-of-pathological-gambling-and-co-occurring-mental-health-and-substance-use-disorders
#17
Rosa Rodriguez-Monguio, Evelyn Brand, Rachel Volberg
OBJECTIVES: Disordered gambling often co-occurs with psychiatric and substance use disorders. The study aim was to assess the healthcare costs of pathological gambling (PG) and co-occurring mental health and substance use disorders by payer. This is the first-of-its-kind economic analysis of addictive behaviors and mental health disorders. METHODS: Study data were derived from the Massachusetts All-Payer Claims Data-a representative health claims database-for the period 2009 to 2013...
October 24, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29039214/pharmaceutical-pricing-in-japan-market-evidence-for-rheumatoid-arthritis-treatment
#18
Jörg Mahlich, Isao Kamae, Rosarin Sruamsiri
BACKGROUND: Drug price setting is one of the key challenges faced by the Japanese health care system. This study aims to identify the determinants of drug price in Japan using the example of the rheumatoid arthritis (RA) treatment market. RESEARCH DESIGN AND METHODS: In order to compare prices across different products, we calculated prices per defined daily dose using WHO methodology. Price determinants were calculated both at launch and over time using IMS quarterly data on medicines approved for RA treatment in Japan from 2012 to 2015...
November 3, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/29038067/clay-minerals-properties-and-applications-to-dermocosmetic-products-and-perspectives-of-natural-raw-materials-for-therapeutic-purposes-a-review
#19
REVIEW
Jemima Daniela Dias Moraes, Silvana Raquel Alina Bertolino, Silvia Lucia Cuffini, Diego Fernando Ducart, Pedro Eriberto Bretzke, Gislaine Ricci Leonardi
Clay minerals are layered materials with a number of peculiar properties, which find many relevant applications in various industries. Since they are easily found everywhere, they are particularly attractive due to their economic viability. In the cosmetic industry, clay minerals are often used as excipients to stabilize emulsions or suspensions and to modify the rheological behavior of these systems. They also play an important role as adsorbents or absorbents, not only in cosmetics but also in other industries, such as pharmaceuticals...
October 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29036424/frailty-and-healthcare-costs-longitudinal-results-of-a-prospective-cohort-study
#20
André Hajek, Jens-Oliver Bock, Kai-Uwe Saum, Herbert Matschinger, Hermann Brenner, Bernd Holleczek, Walter E Haefeli, Dirk Heider, Hans-Helmut König
Objective: to investigate how frailty and frailty symptoms affect healthcare costs in older age longitudinally. Methods: data were gathered from a prospective cohort study in Saarland, Germany (two waves with 3-year interval, n = 1,636 aged 57-84 years at baseline). Frailty was assessed by the five Fried frailty criteria. Frailty was defined as having at least three criteria, the presence of 1-2 criteria as 'pre-frail'. Healthcare costs were quantified based on self-reported healthcare use in the sectors of inpatient treatment, outpatient treatment, professional nursing care and informal care as well as the provision of pharmaceuticals, medical supplies and dental prostheses...
September 21, 2017: Age and Ageing
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