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Pharmaceutical economics

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https://www.readbyqxmd.com/read/28933010/economic-evaluation-of-dupilumab-for-the-treatment-of-moderate-to-severe-atopic-dermatitis-in-adults
#1
Andreas Kuznik, Gaëlle Bégo-Le-Bagousse, Laurent Eckert, Abhijit Gadkari, Eric Simpson, Christopher N Graham, LaStella Miles, Vera Mastey, Puneet Mahajan, Sean D Sullivan
INTRODUCTION: Dupilumab significantly improves signs and symptoms of atopic dermatitis (AD), including pruritus, symptoms of anxiety and depression, and health-related quality of life versus placebo in adults with moderate-to-severe AD. Since the cost-effectiveness of dupilumab has not been evaluated, the objective of this analysis was to estimate a value-based price range in which dupilumab would be considered cost-effective compared with supportive care (SC) for treatment of moderate-to-severe AD in an adult population...
September 20, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28926636/the-expected-and-unexpected-benefits-of-dispensing-the-exact-number-of-pills
#2
Carole Treibich, Sabine Lescher, Luis Sagaon-Teyssier, Bruno Ventelou
BACKGROUND: From November 2014 to November 2015, an experiment in French community pharmacies replaced traditional pre-packed boxes by per-unit dispensing of pills in the exact numbers prescribed, for 14 antibiotics. METHODS: A cluster randomised control trial was carried out in 100 pharmacies. 75 pharmacies counted out the medication by units (experimental group), the other 25 providing the treatment in the existing pharmaceutical company boxes (control group)...
2017: PloS One
https://www.readbyqxmd.com/read/28919795/type-2-diabetes-in-vietnam-a-cross-sectional-prevalence-based-cost-of-illness-study
#3
Nguyen Tu Dang Le, Luyen Dinh Pham, Trung Quang Vo
BACKGROUND: According to the International Diabetes Federation, total global health care expenditures for diabetes tripled between 2003 and 2013 because of increases in the number of people with diabetes as well as in the average expenditures per patient. This study aims to provide accurate and timely information about the economic impacts of type 2 diabetes mellitus (T2DM) in Vietnam. METHOD: The cost-of-illness estimates followed a prospective, prevalence-based approach from the societal perspective of T2DM with 392 selected diabetic patients who received treatment from a public hospital in Ho Chi Minh City, Vietnam, during the 2016 fiscal year...
2017: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/28910222/restricted-access-state-medicaid-coverage-of-sofosbuvir-hepatitis-c-treatment
#4
Marea B Tumber
Chronic hepatitis C (HCV) infection can persist for decades without symptoms. Many Americans are unaware of their infection status and are not receiving necessary care and treatment. This places them at greater risk for severe, even fatal, complications from the disease and increases the likelihood that they will transmit the virus to others. In late 2013, the Food and Drug Administration approved a direct acting antiviral drug called sofosbuvir to treat chronic HCV infection. Sofosbuvir is a highly effective, but very expensive, curative treatment for HCV...
January 2017: Journal of Legal Medicine
https://www.readbyqxmd.com/read/28906232/the-pharmaceutical-industry-and-the-canadian-government-folie-%C3%A3-deux
#5
Joel Lexchin
The interest of the pharmaceutical industry is in achieving a profit for its shareholders while the interest of the Canadian government should be in protecting public health. However, over the course of the past few decades the actions of the Canadian government have been tilted in favour of industry in two areas. The first is in the relationship between industry and Health Canada and is manifested in the regulation of clinical trials, the drug approval system, drug safety and promotion. The second is in economic policy as it applies to policies about patent protection, the price of medications and measures taken to incentivize research and development...
August 2017: Healthcare Policy, Politiques de Santé
https://www.readbyqxmd.com/read/28898296/characterizing-the-interaction-between-physicians-pharmacists-and-pharmaceutical-representatives-in-a-middle-income-country-a-qualitative-study
#6
Rima Hajjar, Aya Bassatne, Mohamad Ali Cheaito, Rabie Naser El Dine, Sarah Traboulsy, Fadi Haddadin, Gladys Honein-AbouHaidar, Elie A Akl
BACKGROUND: Studies around the world have shown that interactions between pharmaceutical companies, pharmacists and physicians have a great influence on prescribing and drug dispensing practices. In middle-income countries, the nature and extent of these interactions have not been well researched. Our objectives were to qualitatively explore the nature of the interactions between pharmaceutical companies, physicians and pharmacists, their impact on drug prescription and dispensing practices in Lebanon...
2017: PloS One
https://www.readbyqxmd.com/read/28892772/multi-class-of-endocrine-disrupting-compounds-in-aquaculture-ecosystems-and-health-impacts-in-exposed-biota
#7
REVIEW
Nur Afifah Hanun Ismail, Sze Yee Wee, Ahmad Zaharin Aris
Fishes are a major protein food source for humans, with a high economic value in the aquaculture industry. Because endocrine disrupting compounds (EDCs) have been introduced into aquatic ecosystems, the exposure of humans and animals that depend on aquatic foods, especially fishes, should be seriously considered. EDCs are emerging pollutants causing global concern because they can disrupt the endocrine system in aquatic organisms, mammals, and humans. These pollutants have been released into the environment through many sources, e...
September 8, 2017: Chemosphere
https://www.readbyqxmd.com/read/28872702/enhancement-of%C3%A2-l-phenylalanine-production-in-escherichia-coli-by-heterologous-expression-of-vitreoscilla-hemoglobin
#8
Wei-Bin Wu, Xiao-Lei Guo, Ming-Liang Zhang, Qing-Gen Huang, Feng Qi, Jian-Zhong Huang
L-phenylalanine is an important amino acid that is widely used in the production of food flavors and pharmaceuticals. Generally, L-phenylalanine production by engineered Escherichia coli requires a high rate of oxygen supply. However, the co-expression of Vitreoscilla hemoglobin gene (vgb), driven bya tac promoter, with the genes encoding 3-deoxy-D-arabinoheptulosonate-7-phosphate synthetase (aroF) and feedback-resistant chorismate mutase/prephenate dehydratase (pheA(fbr) ), led to increased productivity and decreased demand for aeration by E...
September 5, 2017: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/28869327/seasonal-variation-of-effectiveness-of-the-boar-operated-system-to-deliver-baits-to-wild-boar
#9
F Ferretti, J Coats, D Cowan, S Pietravalle, G Massei
BACKGROUND: Wild boar and feral pig numbers are growing worldwide and have substantial economic and environmental impacts. Bait-delivered pharmaceuticals such as disease vaccines, toxicants and contraceptives are advocated to mitigate these impacts. Effective campaigns based on these pharmaceuticals rely on optimising the target species' bait uptake, that might differ between seasons. We investigated seasonal differences in use of Boar-Operated-Systems (BOS) by wild boar and non-target species in an English woodland...
September 4, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28867540/finding-hidden-treasures-in-old-drugs-the-challenges-and-importance-of-licensing-generics
#10
Melek Simsek, Berrie Meijer, Adriaan A van Bodegraven, Nanne K H de Boer, Chris J J Mulder
Identifying new indications for existing drugs creates new therapeutic options while bypassing much of the costs and time involved with bringing a new drug to market. The rediscovery of a generic drug, however, is a challenging pursuit because there is no formal regulatory approach and a lack of economic interest by pharmaceutical companies. This played a part in the re-registration of thioguanine as a rescue drug for the treatment of patients with inflammatory bowel disease in The Netherlands. In this article, we aim to underline the importance of drug rediscovery, the difficulties of this procedure in Europe and we attempt to suggest conceivable solutions...
September 1, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28853698/prioritization-of-diseases-for-the-development-of-a-pharmaceutical-care-service-model-in-south-korea-using-the-analytic-hierarchy-process%C3%A2
#11
Kiyon Rhew, Nayoung Han, Keun-Tae Cho, Jeong-Hyun Yoon, Jung Mi Oh
OBJECTIVE: Drug therapy plays a critical role in most chronic diseases. Effectiveness of pharmaceutical care services in the improvement of clinical, social, or economic outcomes has been scientifically proven through numerous studies. In South Korea, to optimize and standardize pharmaceutical care for patients with chronic metabolic diseases, the development of a pharmaceutical care service model is needed. MATERIALS: To determine the priority of diseases in developing pharmaceutical care service models, analytic hierarchny process (AHP)analysis was used...
August 30, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28851428/social-and-economic-value-of-portuguese-community-pharmacies-in-health-care
#12
Jorge Félix, Diana Ferreira, Marta Afonso-Silva, Marta Vargas Gomes, César Ferreira, Björn Vandewalle, Sara Marques, Melina Mota, Suzete Costa, Maria Cary, Inês Teixeira, Ema Paulino, Bruno Macedo, Carlos Maurício Barbosa
BACKGROUND: Community pharmacies are major contributors to health care systems across the world. Several studies have been conducted to evaluate community pharmacies services in health care. The purpose of this study was to estimate the social and economic benefits of current and potential future community pharmacies services provided by pharmacists in health care in Portugal. METHODS: The social and economic value of community pharmacies services was estimated through a decision-model...
August 29, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28842310/designing-optimal-formulations-for-hot-melt-coating
#13
Diogo Gomes Lopes, Sharareh Salar-Behzadi, Andreas Zimmer
Hot-melt coating (HMC) as a solvent-free technology grants faster and more economic coating processes with reduced risk of dissolving the drug during the process. Moreover, traditional coating equipment can be modified to enable the HMC process. Despite the indubitable advantages and feasibility of the process, HMC is not well-known to pharmaceutical industry and its employment is still limited. The main aspect hindering the widespread application of this technique is the need of materials alternative to the conventional polymeric coatings...
August 22, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28840772/a-health-economic-lifetime-treatment-pathway-model-for-low-back-pain-in-sweden
#14
Gylfi Olafsson, Emma Jonsson, Peter Fritzell, Olle Hägg, Fredrik Borgström
AIMS: To develop a health economic model to evaluate the long-term costs and outcomes over the healthcare treatment pathway for patients with low back pain (LBP). MATERIALS AND METHODS: A health economic model, consisting of a decision tree structure with a Markov microsimulation model at the end of each branch, was created. Patients were followed from first observed clinical presentation with LBP until the age of 100 years or death. The underlying data to populate the model were based on Swedish national and regional registry data on healthcare resource use and sickness insurance in patients presenting with LBP in the Swedish region Västra Götaland during 2008-2012...
September 11, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28830488/trends-in-the-prescription-of-benzodiazepines-for-the-elderly-in-korea
#15
Soo-Hee Hwang, Seungjin Han, Hyojung Choi, Choonseon Park, Sun Min Kim, Tae Hyun Kim
BACKGROUND: This study examined trends in the prescription of benzodiazepines for the elderly (age over 65 years) in Korea, a country with a higher level of spending on pharmaceuticals compared to that in other Organization for Economic Cooperation and Development (OECD) countries, and identified factors related to the inappropriate use of such drugs. METHODS: We used the National Health Insurance Claims Data (NHICD) for the period 2009-2013, including all reimbursed drug-prescribing information...
August 22, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28828741/health-expenditure-and-all-cause-mortality-in-the-galaxy-of-italian-regional-healthcare-systems-a-15-year-panel-data-analysis
#16
Davide Golinelli, Fabrizio Toscano, Andrea Bucci, Jacopo Lenzi, Maria Pia Fantini, Nicola Nante, Gabriele Messina
BACKGROUND: The sustainability of healthcare systems is a topic of major interest. During periods of economic instability, policy makers typically reallocate resources and execute linear cuts in different areas of public spending, including healthcare. OBJECTIVES: The aim of this paper was to examine whether and how per capita public healthcare expenditure (PHE) in the Italian regions was related to the all-cause mortality rate (MR) between 1999 and 2013 and to determine which expenditure item most affected mortality in the short and very short term...
August 21, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28822846/islet-g-protein-coupled-receptors-therapeutic-potential-for-diabetes
#17
REVIEW
Shanta J Persaud
The incidence of type 2 diabetes (T2D) is increasing at an alarming rate, which is imposing substantial healthcare and economic burdens worldwide. T2D can be treated by a range of drugs, but there is a need to identify additional therapeutic options. Human islets express nearly three hundred G-protein-coupled receptors (GPCRs), which could be targeted for the treatment of T2D. However, to date, the GLP-1 receptor is the only islet GPCR for which agonists are in current clinical use. This review explores pharmaceutical development of drugs that activate individual or multiple β-cell GPCRs and explains how our knowledge of GPCR expression by human islets may inform direction on novel GPCR targets...
August 17, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/28822173/-breakthrough-in-key-science-and-technologies-in-dendrobium-catenatum-industry
#18
Ji-Ping Si, Qi Wang, Zhong-Jian Liu, Jing-Jing Liu, Yi-Bo Luo
In view of the significant difficulties of propagation, planting and simple product in Dendrobium catenatum(D. officinale)industry development, a series of research were carried out. Genome study showed that D. catenatum is a specie of diploid with 38 chromosomes and 28 910 protein-coding genes. It was identified that specific genes accumulated in different organs at the transcriptome level. We got an insight into the gene regulation mechanism of the loss of the endospermous seed, the wide ecological adaptability and the synthesis of polysaccharides, which provided a theoretical basis for genetic engineering breeding and development and utilization of active pharmaceutical ingredients...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28812229/economics-and-cost-effectiveness-of-multiple-sclerosis-therapies-in-the-usa
#19
REVIEW
Daniel M Hartung
Multiple sclerosis (MS) is a disabling, chronic disease that imposes a significant economic burden on patients and the US healthcare system. The largest cost component for individuals with MS are prescription drugs, specifically disease-modifying therapies (DMTs). Despite an increase in the number and diversity of DMTs over the past 10 years, acquisition costs for all DMTs have escalated dramatically at rates substantially higher than medical inflation. Currently, costs for most DMTs exceed $70,000 a year. Recent cost-effectiveness studies suggest the cost for nearly all DMTs exceeds generally accepted thresholds for what is considered a good value in the USA, even after factoring expected rebates...
August 15, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28804600/analysis-of-health-economics-assessment-reports-for-pharmaceuticals-in-france-understanding-the-underlying-philosophy-of-ceesp-assessment
#20
Mondher Toumi, Anastasiia Motrunich, Aurélie Millier, Cécile Rémuzat, Christos Chouaid, Bruno Falissard, Samuel Aballéa
Background: Despite the guidelines for Economic and Public Health Assessment Committee (CEESP) submission having been available for nearly six years, the dossiers submitted continue to deviate from them, potentially impacting product prices. Objective: to review the reports published by CEESP, analyse deviations from the guidelines, and discuss their implications for the pricing and reimbursement process. Study design: CEESP reports published until January 2017 were reviewed, and deviations from the guidelines were extracted...
2017: Journal of Market Access & Health Policy
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