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Pharmaceutical economics

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https://www.readbyqxmd.com/read/28428184/clinical-and-cost-effectiveness-safety-and-acceptability-of-community-intravenous-antibiotic-service-models-civas-systematic-review
#1
E D Mitchell, C Czoski Murray, D Meads, J Minton, J Wright, M Twiddy
OBJECTIVE: Evaluate evidence of the efficacy, safety, acceptability and cost-effectiveness of outpatient parenteral antimicrobial therapy (OPAT) models. DESIGN: A systematic review. DATA SOURCES: MEDLINE, EMBASE, CINAHL, Cochrane Library, National Health Service (NHS) Economic Evaluation Database (EED), Research Papers in Economics (RePEc), Tufts Cost-Effectiveness Analysis (CEA) Registry, Health Business Elite, Health Information Management Consortium (HMIC), Web of Science Proceedings, International Pharmaceutical Abstracts, British Society for Antimicrobial Chemotherapy website...
April 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28425297/new-approaches-for-itaconic-acid-production-bottlenecks-and-possible-remedies
#2
Richa Bafana, R A Pandey
Currently, growing attention is being devoted to the conversion of biomass into value-added products, such as itaconic acid (IA), which is considered as the cleanest alternative to petroleum-based acrylic acid. IA is an unsaturated dicarboxylic acid that is used as a building block chemical for the production of several value-added products such as poly-itaconic acid. IA and its derivatives have a wide range of potential applications in textile, paint, pharmaceutical and chemical industries. Presently, industries are producing IA on the large scale by fermentation from glucose...
April 20, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28424767/direct-and-indirect-costs-of-asthma-management-in-greece-an-expert-panel-approach
#3
Kyriakos Souliotis, Hara Kousoulakou, Georgios Hillas, Petros Bakakos, Michalis Toumbis, Stelios Loukides, Theodoros Vassilakopoulos
OBJECTIVE: Asthma is a major cause of morbidity and mortality and is associated with significant economic burden worldwide. The objectives of this study were to map current resource use associated with the disease management and to estimate the annual direct and indirect costs per adult patient with asthma. METHODS: A Delphi panel with seven leading pulmonologists was conducted. A semistructured questionnaire was developed to elicit data on resource use and treatment patterns...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28421986/all-solid-state-pvc-membrane-and-carbon-paste-ion-selective-electrodes-for-determination-of-donepezil-hydrochloride-in-pharmaceutical-formulation
#4
Nesreen Khamees, Tagreed Abdel-Fattah Mohamed, Abeer Rashad Derar, Azza Aziz
All-solid-state, polyvinyl chloride (PVC) membrane, and carbon paste potentiometric ion-selective electrodes (ISEs) were proposed for the determination of donepezil hydrochloride (DON) in the drug substance and a pharmaceutical formulation. The potentiometric response toward DON was based on the existence of donepezil-tetraphenyl borate (DON-TPB) in a PVC membrane or a carbon paste in the presence of dioctylphthalate. In contrast, the solid-state electrode was prepared by direct incorporation of DON-TPB into a commercial nail varnish without external additives...
April 18, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28421287/-age-89-years-depression-fall-with-pelvic-fracture-severe-confusion-serotonin-syndrome-differential-diagnosis-importance-of-cyp450-and-economic-considerations
#5
REVIEW
W Weinrebe, A Moutaouakil, K Risz, M Martin, K Jeckelmann, S Goetz
A case study of an 89-year-old patient is reported, who was admitted to hospital because of immobility due to pain. After the cause of the pain could initially be clarified and treated, the further clinical course in this very old woman showed an alarming symptom complex of agitation, confusion and cognitive deterioration, which took on grave forms. The work-up of this case showed a typical constellation of pain and depression in old age; however, the pharmaceutical treatment in this case is not atypical and could lead to a severe serotonin syndrome...
April 18, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28419600/reformulations-of-well-known-active-ingredients-in-the-topical-treatment-of-psoriasis-vulgaris-can-improve-clinical-outcomes-for-patients
#6
REVIEW
L Iversen, E Dauden, S Segaert, K Freeman, S Magina, D Rigopoulos, D Thaci
BACKGROUND: Although the majority of patients with psoriasis vulgaris are treated exclusively with topical therapies, research to develop more effective topical therapies that are associated with higher patient satisfaction has lagged behind the development of systemic agents. OBJECTIVE: The aim of this literature review was to determine whether there is documented evidence that applying an innovative approach to improving the formulation of active ingredients commonly used in the topical treatment of psoriasis can have a positive effect on clinical outcomes and patient-reported outcomes (PROs)...
April 17, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28412912/the-socioeconomic-effects-of-uncontrolled-hypertension
#7
Kostas Athanasakis
Hypertension (HT), albeit a modifiable risk factor of cardiovascular morbidity and mortality, remains one of the main contributors to the total disease burden internationally and, thus, inevitably one of the basic cost drivers in healthcare systems. Taking the above into account, this brief narrative review aims at presenting the main findings of the international health economics literature on HTwith regards to four key areas: a) the costs attributable to HT, b) the effects of HTon patient well-being, c) the cost-effectiveness of pharmaceutical interventions against high blood pressure, and, d) the costs and benefits of preventive measures against HT...
April 13, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28409915/nitrogen-and-phosphorus-harvesting-from-human-urine-using-a-stripping-absorption-and-precipitation-process
#8
Surendra K Pradhan, Anna Mikola, Riku Vahala
Human urine contains significant amounts of N (nitrogen) and P (phosphorus); therefore it has been successfully used as fertilizer in different crops. But the use of urine as fertilizer has several constraints, such as, the high cost of transportation, an unpleasant smell, the risk of pathogens, and pharmaceutical residue. A combined and improved N stripping and P precipitation technique is used in this study. In this technique, Ca(OH)2 is used to increase the pH of urine which converts ammonium into ammonia gas and precipitate P as Ca-P compound...
April 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28403898/health-risks-associated-with-the-pharmaceuticals-in-wastewater
#9
EDITORIAL
Nasser Nassiri Koopaei, Mohammad Abdollahi
The overwhelming population growth in recent decades and water crisis along with limited and uneven geographical distribution of fresh water resources is a growing challenge for the economic and human development. Wastewater reclamation and use could be an alternative for intact water sources and a promising solution to water scarcity and unequal distribution. However, wastewater is a double-edged resource both as an accessible water source for food production and human usage and concurrently may carry uncharacterized content with unknown toxicological profile causing acute or long-term health risks...
April 12, 2017: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/28397187/synthesis-of-ureas-from-co2
#10
REVIEW
Hua Wang, Zhuo Xin, Yuehui Li
Ureas are an important class of bioactive organic compounds in organic chemistry and exist widely in natural products, agricultural pesticides, uron herbicides, pharmaceuticals. Even though urea itself has been synthesized from CO2 and ammonia for a long time, the selective and efficient synthesis of substituted ureas is still challenging due to the difficulty of dehydration processes. Efficient and economic fixation of CO2 is of great importance in solving the problems of resource shortages, environmental issues, global warming, etc...
April 2017: Topics in Current Chemistry (Journal)
https://www.readbyqxmd.com/read/28394965/-ethical-conflicts-in-the-authorship-of-scientific-papers
#11
Astrid von Oetinger, Kabir P Sadarangani, Sofía P Salas
The frequency of conflicts about authorship of publications has increased along with the increase in the number of people involved in scientific work. Some of the factors that strongly influence the generation of conflicts and malpractices in authorship definition of scientific publications are the pressure of academia, economic incentives from the pharmaceutical industry in the field of biomedicine and authors’ wishes and expectations of recognition, among other factors. The article analyzes this problem, increasingly common in the field of medicine and related areas...
November 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28392011/rationing-hepatitis-c-treatment-in-the-context-of-austerity-policies-in-france-and-cameroon-a-transnational-perspective-on-the-pharmaceuticalization-of-healthcare-systems
#12
Fanny Chabrol, Pierre-Marie David, Gaëlle Krikorian
New powerful drugs against hepatitis C can cure the disease, but they are not widely distributed because their exorbitant prices are destabilizing healthcare systems in both African and European countries. This article takes access to hepatitis C treatments since 2013 in France and in Cameroon as a lens to analyze the rationing of pharmaceutical treatments in relation to recent transformations of health systems. Access to these treatments is analyzed thanks to ethnographic observation and interviews lead in Paris and Yaoundé, with patients, associations, health professionals and public health experts...
March 28, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28391705/microbial-cell-immobilization-in-biohydrogen-production-a-short-overview
#13
Patrick Thabang Sekoai, Ayotunde A Awosusi, Kelvin Odafe Yoro, Muofhe Singo, Olawale Oloye, Augustine Omoniyi Ayeni, Michael Bodunrin, Michael Olawale Daramola
The high dependence on fossil fuels has escalated the challenges of greenhouse gas emissions and energy security. Biohydrogen is projected as a future alternative energy as a result of its non-polluting characteristics, high energy content (122 kJ/g), and economic feasibility. However, its industrial production has been hampered by several constraints such as low process yields and the formation of biohydrogen-competing reactions. This necessitates the search for other novel strategies to overcome this problem...
April 10, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28380593/alginate-increases-water-stability-whilst-maintaining-diet-digestibility-in-farmed-saltwater-crocodiles
#14
Magdalene Francis, Patrick C H Morel, Brian H P Wilkinson, Timothy J Wester
Saltwater crocodile () farming in Papua New Guinea is an emerging industry that supplies high-quality skins to the fashion industry. Crocodiles are semiaquatic and fed high-quality feed made from extrudated animal byproducts (i.e., forced through a die at low pressure but not heat treated); however, it disintegrates on contact with water, and this leads to low utilization. Alginate is used extensively in food and pharmaceutical processes because it quickly forms a gel at room temperature; however, its effects on nutrient availability are equivocal, and its utility in crocodile diets is unknown...
February 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28377260/infection-after-fracture-fixation-of-the-tibia-analysis-of-healthcare-utilization-and-related-costs
#15
Willem-Jan Metsemakers, Bart Smeets, Stefaan Nijs, Harm Hoekstra
INTRODUCTION: One of the most challenging complications in musculoskeletal trauma surgery is the development of infection after fracture fixation (IAFF). It can delay healing, lead to permanent functional loss, or even amputation of the affected limb. The main goal of this study was to investigate the total healthcare costs and length-of-stay (LOS) related to the surgical treatment of tibia fractures and furthermore identify the subset of clinical variables driving these costs within the Belgian healthcare system...
March 22, 2017: Injury
https://www.readbyqxmd.com/read/28370510/socio-economic-burden-of-participation-in-clinical-trials-in-patients-with-myeloproliferative-neoplasms
#16
Swati Goel, Chiara Paoli, Alessandra Iurlo, Arturo Pereira, Fabio Efficace, Tiziano Barbui, Ayalew Tefferi, Alessandro M Vannucchi, Francisco Cervantes
OBJECTIVE: To determine the financial and psycho-social impact of participation in clinical trials of patients with BCR/ABL-negative myeloproliferative neoplasms (MPN). METHODS: An international, observational cross section study was performed in 143 consecutive MPN patients (51% myelofibrosis, 36% polycythemia vera, 13% essential thrombocythemia), 68% from Italy, 17% from USA, and 15% from Spain. RESULTS: Thirty-five percent of patients reported having spent more money during the trial than in previous treatments and 21% having missed more workdays...
March 31, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28369066/socioeconomic-factors-explain-suboptimal-adherence-to-antiretroviral-therapy-among-hiv-infected-australian-adults-with-viral-suppression
#17
Krista J Siefried, Limin Mao, Stephen Kerr, Lucette A Cysique, Thomas M Gates, John McAllister, Anthony Maynard, John de Wit, Andrew Carr
BACKGROUND: Missing more than one tablet of contemporary antiretroviral therapy (ART) per month increases the risk of virological failure. Recent studies evaluating a comprehensive range of potential risk factors for suboptimal adherence are not available for high-income settings. METHODS: Adults on ART with undetectable viral load (UDVL) were recruited into a national, multi-centre cohort, completing a comprehensive survey assessing demographics, socio-economic indicators, physical health, well-being, life stressors, social supports, HIV disclosure, HIV-related stigma and discrimination, healthcare access, ART regimen, adherence, side effects, costs and treatment beliefs...
2017: PloS One
https://www.readbyqxmd.com/read/28367095/high-production-of-2-3-butanediol-by-a-mutant-strain-of-the-newly-isolated-klebsiella-pneumoniae-srp2-with-increased-tolerance-towards-glycerol
#18
Md Shafiqur Rahman, Chunbao Charles Xu, Kesen Ma, Malaya Nanda, Wensheng Qin
Biodiesel, a renewable fuel produced by transesterification of animal fats and vegetable oils, generates about 10% (v/v) of crude glycerol as a core byproduct. The high volume of this non bio-degradable glycerol is becoming of a great environmental and economical concern due to its worldwide ever-growing surplus. Herein we report a high production of 2,3-butanediol (2,3-BD) from pure and biodiesel derived crude glycerol using a mutant K. pneumoniae SRM2 obtained from a newly isolated strain Klebsiella pneumoniae SRP2...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28360012/assessment-of-olea-europaea-l-fruit-extracts-phytochemical-characterization-and-anticancer-pathway-investigation
#19
Amina Maalej, Zouhaier Bouallagui, Fatma Hadrich, Hiroko Isoda, Sami Sayadi
Olea europaea L. has been widely used as an advantageous rich source of bioactive compounds of high economic value leading to its use in pharmaceutical, cosmetic, and agriculture industries. Ethanolic extracts of olive fruits from three different cultivars (OFE) were studied for their phytochemical contents and were investigated for antioxidant activities and anticancer potential. Major polyphenols detected in these extracts were tyrosol, hydroxytyrosol, oleuropein, rutin, quercetin and glucoside forms of luteolin and apigenin...
March 27, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28343208/legal-features-of-the-drug-advertising
#20
Vitalii M Pashkov, Andrii A Olefir, Oleksiy Y Bytyak
INTRODUCTION: In the article discribed current trends of advertising in the pharmaceutical market and foreign experience of legal regulation of these relations. As for the advertising of medicines identified it's symptoms, types, basic rules and prohibitions. Modern pharmaceutical companies can not successfully carry out economic activities without advertising. Besides we can mention some fundamental changes in society (information overload, universal access to internet, social media, freedom of movement of goods, labor and finance), also self-medication becomes more popular...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
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