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Pharmaceutical economics

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https://www.readbyqxmd.com/read/28203069/the-pharmacological-cost-of-copd-during-greek-economic-crisis
#1
Eirini Stafyla, Theodora Kerenidi, Irini Gerogianni, Mary Geitona, Zoe Daniil, Konstantinos I Gourgoulianis
INTRODUCTION: The economic crisis in Greece has substantially affected patients with COPD. The reduction of disposable income has its consequences on patients' ability to afford their medication. The aim of the study is to evaluate the cost of treatment for patients with COPD and the influence of the financial crisis to the patients. METHODS: Data were collected from 189 patients (male: 178, mean age: 70.1±8.4) who visited the outpatient department of University Hospital of Larissa in 2014 and 2015...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28178881/nanobiotech-in-big-pharma-a-business-perspective
#2
Martin Würmseher, Lea Firmin
Since the early 2000s, numerous publications have presented major scientific opportunities that can be achieved through integrating insights from the area of nanotech into biotech (nanobiotech). This paper aims to explore the economic significance that nanobiotech has gained in the established pharmaceutical industry (big pharma). The empirical investigation draws on patent data as well as product revenue data; and to put the results into perspective, the amounts are compared with the established/traditional biotech sector...
March 2017: Nanomedicine
https://www.readbyqxmd.com/read/28170142/catalytic-alkylation-using-a-cyclic-s-adenosylmethionine-regeneration-system
#3
Silja Mordhorst, Jutta Siegrist, Michael Müller, Michael Richter, Jennifer N Andexer
S-Adenosylmethionine-dependent methyltransferases are versatile tools for the specific alkylation of many compounds, such as pharmaceuticals, but their biocatalytic application is severely limited owing to the lack of a cofactor regeneration system. We report a biomimetic, polyphosphate-based, cyclic cascade for methyltransferases. In addition to the substrate to be methylated, only methionine and polyphosphate have to be added in stoichiometric amounts. The system acts catalytically with respect to the cofactor precursor adenosine in methylation and ethylation reactions of selected substrates, as shown by HPLC analysis...
February 7, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28168142/electrochemical-alcohol-oxidation-mediated-by-tempo-like-nitroxyl-radicals
#4
REVIEW
Rosaria Ciriminna, Mina Ghahremani, Babak Karimi, Mario Pagliaro
The electrocatalytic oxidation of alcohols mediated by TEMPO-like nitroxyl radicals is an economically and industrially viable method that will shortly find commercial application in the synthesis of valued substances including active pharmaceutical ingredients (APIs), valued natural product derivatives, fine chemicals, and valued nanomaterials.
February 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28167450/extraction-optimization-and-in-vitro-and-in-vivo-anti-postprandial-hyperglycemia-effects-of-inhibitor-from-phoenix-dactylifera-l-parthenocarpic-fruit
#5
Hanen El Abed, Mouna Chakroun, Imen Fendri, Mohamed Makni, Mohamed Bouaziz, Noureddine Drira, Hafedh Mejdoub, Bassem Khemakhem
Phoenix dactylifera L. plays an important role in social, economic, and ecological Tunisian sectors. Some date palms produce parthenocarpic fruit named Sish. The aqueous ethanolic extract from P. dactylifera parthenocarpic dates demonstrated a potent inhibition of the enzymes related to type II diabetes. In this work, extraction optimization of amylase inhibitors was carried out using Box-Behnken Design. Bioactivity-guided fractionation of the 70% aqueous ethanol extract was performed to identify the active compounds...
February 3, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28152420/barriers-to-accessing-adequate-maternal-care-in-central-and-eastern-european-countries-a-systematic-literature-review
#6
Elina Miteniece, Milena Pavlova, Bernd Rechel, Wim Groot
Maternal health outcomes in Central and Eastern Europe (CEE) compare unfavorable with those in Western Europe, despite macro-indicators that suggest well-designed maternal care systems. However, macro-indicators at the system level only capture capacity, funding and utilization of care and not the actual allocation of financial and human resources, the quality of care and access to it. It is these latter which are problematic in the CEE region. In this study service-related indicators of access to maternal care in CEE are examined...
January 24, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28139089/a-bias-adjusted-evidence-synthesis-of-rct-and-observational-data-the-case-of-total-hip-replacement
#7
Petra Schnell-Inderst, Cynthia P Iglesias, Marjan Arvandi, Oriana Ciani, Raffaella Matteucci Gothe, Jaime Peters, Ashley W Blom, Rod S Taylor, Uwe Siebert
Evaluation of clinical effectiveness of medical devices differs in some aspects from the evaluation of pharmaceuticals. One of the main challenges identified is lack of robust evidence and a will to make use of experimental and observational studies (OSs) in quantitative evidence synthesis accounting for internal and external biases. Using a case study of total hip replacement to compare the risk of revision of cemented and uncemented implant fixation modalities, we pooled treatment effect estimates from OS and RCTs, and simplified existing methods for bias-adjusted evidence synthesis to enhance practical application...
February 2017: Health Economics
https://www.readbyqxmd.com/read/28137644/measuring-the-effectiveness-and-impact-of-an-open-innovation-platform
#8
REVIEW
Glenn P Carroll, Sanjay Srivastava, Adam S Volini, Marta M Piñeiro-Núñez, Tatiana Vetman
Today, most pharmaceutical companies complement their traditional R&D models with some variation on the Open Innovation (OI) approach in an effort to better access global scientific talent, ideas and hypotheses. Traditional performance indicators that measure economic returns from R&D through commercialization are often not applicable to the practical assessment of these OI approaches, particularly within the context of early drug discovery. This leaves OI programs focused on early R&D without a standard assessment framework from which to evaluate overall performance...
January 27, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28128923/base-mediated-hydroamination-of-alkynes
#9
Monika Patel, Rakesh K Saunthwal, Akhilesh K Verma
Inter- or intramolecular hydroamination reactions are a paradigmatic example of modern sustainable organic chemistry, as they are a catalytic, 100% atom-economical, and waste-free process of fundamental simplicity in which an amine is added to an alkyne substrate. Many enamines are found in many natural and synthetic compounds possessing interesting physiological and biological activities. The development of synthetic protocols for such molecules and their transformation is a persistent research topic in pharmaceutical and organic chemistry...
January 27, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28125930/from-coastal-to-global-the-transnational-flow-of-ayurveda-and-its-relevance-for-indo-african-linkages
#10
Caroline Meier Zu Biesen
Driven by long-standing ties with India, and intertwined with global market interests, a growing influx of materia medica from South Asia is currently emerging in East Africa. To compete at a global level and framed within the language of 'South-South cooperation for mutual benefit', India presents itself as an appropriate exporter of medical products suitable for African clientele. The expansion of India's medical sector into Africa is particularly relevant for Ayurvedic pharmaceuticals. Ayurveda's diaspora into Africa exemplifies the emergence of new health interventions and medical assemblages in a transnationally interconnected world and implies innovative coalitions involved in the complex promotion of local/Global Health industries...
January 26, 2017: Global Public Health
https://www.readbyqxmd.com/read/28125373/health-care-resource-utilization-and-costs-in-patients-with-chronic-myeloid-leukemia-with-better-adherence-to-tyrosine-kinase-inhibitors-and-increased-molecular-monitoring-frequency
#11
Dominick Latremouille-Viau, Annie Guerin, Patrick Gagnon-Sanschagrin, Katherine Dea, Benjamin G Cohen, George J Joseph
BACKGROUND: Frequent molecular monitoring (qPCR tests), as recommended by evidence-based monitoring guidelines, is associated with higher adherence to tyrosine kinase inhibitors (TKIs) in the management of chronic myeloid leukemia (CML); both factors have been associated with better clinical and economic outcomes. OBJECTIVES: To (a) estimate the effect of more frequent qPCR tests on health care resource utilization (HRU) and associated costs, including direct (effect of qPCR test frequency on HRU) and indirect (through TKI adherence) effects, and (b) develop an economic model applicable to multiple clinical practice scenarios...
February 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28125370/a-systematic-review-of-the-effect-of-cancer-treatment-on-work-productivity-of-patients-and-caregivers
#12
Khalid M Kamal, Jordan R Covvey, Ankur Dashputre, Somraj Ghosh, Surbhi Shah, Monali Bhosle, Christopher Zacker
BACKGROUND: Cancer is a leading cause of death with substantial financial costs. While significant data exist on the economic burden of care, less is known about the indirect costs of treatment and, specifically, the effect on work productivity of patients and their caregivers. To examine the full effect of cancer and the potential value of new therapies, all aspects of care, including indirect costs and patient-reported outcomes, should be evaluated. OBJECTIVE: To perform a systematic review of the literature examining the effect of cancer treatment on work productivity in patients and their caregivers...
February 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28116955/dutch-guidelines-for-economic-evaluation-from-good-to-better-in-theory-but-further-away-from-pharmaceuticals-in-practice
#13
Livio Garattini, Anna Padula
No abstract text is available yet for this article.
January 1, 2017: Journal of the Royal Society of Medicine
https://www.readbyqxmd.com/read/28109551/-economic-impact-of-optimising-antiretroviral-treatment-in-human-immunodeficiency-virus-infected-adults-with-suppressed-viral-load-in-spain-by-implementing-the-grade-a-1-evidence-recommendations-of-the-2015-gesida-national-aids-plan
#14
Esteban Ribera, José Manuel Martínez-Sesmero, Javier Sánchez-Rubio, Rafael Rubio, Juan Pasquau, José Luis Poveda, Alejandro Pérez-Mitru, Celia Roldán, Beatriz Hernández-Novoa
INTRODUCTION: The objective of this study is to estimate the economic impact associated with the optimisation of triple antiretroviral treatment (ART) in patients with undetectable viral load according to the recommendations from the GeSIDA/PNS (2015) Consensus and their applicability in the Spanish clinical practice. METHODS: A pharmacoeconomic model was developed based on data from a National Hospital Prescription Survey on ART (2014) and the A-I evidence recommendations for the optimisation of ART from the GeSIDA/PNS (2015) consensus...
January 18, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28107722/microalgae-biorefinery-high-value-products-perspectives
#15
Kit Wayne Chew, Jing Ying Yap, Pau Loke Show, Ng Hui Suan, Joon Ching Juan, Tau Chuan Ling, Duu-Jong Lee, Jo-Shu Chang
Microalgae have received much interest as a biofuel feedstock in response to the uprising energy crisis, climate change and depletion of natural sources. Development of microalgal biofuels from microalgae does not satisfy the economic feasibility of overwhelming capital investments and operations. Hence, high-value co-products have been produced through the extraction of a fraction of algae to improve the economics of a microalgae biorefinery. Examples of these high-value products are pigments, proteins, lipids, carbohydrates, vitamins and anti-oxidants, with applications in cosmetics, nutritional and pharmaceuticals industries...
April 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28104969/assessment-of-a-clinical-pharmacy-activity-in-a-pediatric-inpatient-department-in-cote-d-ivoire
#16
Danho Pascal Abrogoua, César Pacôme Békégnran, Bi Marius Gro, Elisée Doffou, Madeleine Amorissani Folquet
BACKGROUND: Clinical pharmacy activities in a pediatric inpatient department help to improve the management of patients clinically and economically. OBJECTIVE: To assess the relevance of pharmaceutical interventions (PIs) in a pediatric inpatient department in Abidjan (Cote d'Ivoire). MATERIALS AND METHODS: We carried out a cross-sectional, descriptive study from February to September 2014. The information collected was classified according to the classification of drug-related problems (DRPs) and PIs of the French Society of Clinical Pharmacy...
December 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/28101462/identification-and-molecular-characterization-of-genes-coding-pharmaceutically-important-enzymes-from-halo-thermo-tolerant-bacillus
#17
Azam Safary, Rezvan Moniri, Maryam Hamzeh-Mivehroud, Siavoush Dastmalchi
Purpose: Robust pharmaceutical and industrial enzymes from extremophile microorganisms are main source of enzymes with tremendous stability under harsh conditions which make them potential tools for commercial and biotechnological applications. Methods: The genome of a Gram-positive halo-thermotolerant Bacillus sp. SL1, new isolate from Saline Lake, was investigated for the presence of genes coding for potentially pharmaceutical enzymes. We determined gene sequences for the enzymes laccase (CotA), l-asparaginase (ansA3, ansA1), glutamate-specific endopeptidase (blaSE), l-arabinose isomerase (araA2), endo-1,4-β mannosidase (gmuG), glutaminase (glsA), pectate lyase (pelA), cellulase (bglC1), aldehyde dehydrogenase (ycbD) and allantoinases (pucH) in the genome of Bacillus sp...
December 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28101128/simultaneous-determination-of-newly-developed-antiviral-agents-in-pharmaceutical-formulations-by-hplc-dad
#18
Nourah Zoman Al-Zoman, Hadir Mohamed Maher, Amal Al-Subaie
BACKGROUND: Ombitasvir/paritaprevir/ritonavir/dasabuvir (Viekira Pak(®)) are the newest medicines approved for use in the treatment of hepatitis C virus (HCV) and are available in tablet form as an oral combination. Specifically, these agents are indicated in the treatment of HCV in patients with genotype 1 infection. Due to the therapeutic importance and increased use of Viekira Pak, proper methods for its determination in bulk and pharmaceutical formulations must be developed. RESULTS: The present study describes the development and validation of a simple, rapid, selective and economical reverse phase high performance liquid chromatography-diode array detection (HPLC-DAD) method for the simultaneous determination of paritaprevir (PAR), ombitasvir (OMB), dasabuvir(DAS) and ritonavir (RIT) in bulk and pharmaceutical preparations...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28100464/six-month-market-exclusivity-extensions-to-promote-research-offer-substantial-returns-for-many-drug-makers
#19
Aaron S Kesselheim, Benjamin N Rome, Ameet Sarpatwari, Jerry Avorn
To incentivize pharmaceutical manufacturers to invest in areas of unmet medical need, policy makers frequently propose extending the market exclusivity period of desired drugs. Some such proposals are modeled after the pediatric exclusivity patent extension program, which since 1997 has provided six additional months of market exclusivity for drugs studied in children. The most recent proposal would encourage rare disease research by providing six months of extended exclusivity for any existing drug that is granted subsequent FDA approval for a new rare disease indication...
January 18, 2017: Health Affairs
https://www.readbyqxmd.com/read/28087127/the-route-from-problem-to-solution-in-multistep-continuous-flow-synthesis-of-pharmaceutical-compounds
#20
Péter Bana, Róbert Örkényi, Klára Lövei, Ágnes Lakó, György István Túrós, János Éles, Ferenc Faigl, István Greiner
Recent advances in the field of continuous flow chemistry allow the multistep preparation of complex molecules such as APIs (Active Pharmaceutical Ingredients) in a telescoped manner. Numerous examples of laboratory-scale applications are described, which are pointing towards novel manufacturing processes of pharmaceutical compounds, in accordance with recent regulatory, economical and quality guidances. The chemical and technical knowledge gained during these studies is considerable; nevertheless, connecting several individual chemical transformations and the attached analytics and purification holds hidden traps...
December 29, 2016: Bioorganic & Medicinal Chemistry
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