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Anders Frid, Andrea Tura, Giovanni Pacini, Martin Ridderstråle
We conducted a double-blind placebo-controlled crossover pilot study to investigate the effect of oat betaglucans (β-glucan) on glycaemic control and variability in adults with type 1 diabetes (T1D; n = 14). Stomacol(®) tablets (1.53 g of β-glucan) or placebo (Plac) were administered three times daily before meals for two weeks. Glucose levels were monitored during the second week by continuous glucose monitoring (CGM). There was an increase in basic measures of glycaemic control (maximal glucose value 341 ± 15 vs...
September 12, 2017: Nutrients
Domenico Sagnelli, Jacob J K Kirkensgaard, Concetta Valeria L Giosafatto, Natalia Ogrodowicz, Krzysztof Kruczała, Mette S Mikkelsen, Jean-Eudes Maigret, Denis Lourdin, Kell Mortensen, Andreas Blennow
Grain polysaccharides represent potential valuable raw materials for next-generation advanced and environmentally friendly plastics. Thermoplastic starch (TPS) is processed using conventional plastic technology, such as casting, extrusion, and molding. However, to adapt the starch to specific functionalities chemical modifications or blending with synthetic polymers, such as polycaprolactone are required (e.g. Mater-Bi). As an alternative, all-natural and compostable bio-plastics can be produced by blending starch with other polysaccharides...
September 15, 2017: Carbohydrate Polymers
Andrzej M Fal, Frank Conrad, Karina Schönknecht, Hartwig Sievers, Anna Pawińska
THE AIM: The in-vitro antiviral activity of the "Virus Blocking Factor" (VBF), a combination of Pelargonium extract and Sambucus juice with addition of Betaglucan 1,3 / 1,6, Zincum gluconium, Acidum ascorbicum, was studied against human pathogenic viruses: Influenza A H1N1 (FluA H1N1), Rhinovirus B subtype 14 (HRV14), Respiratory Syncytial Virus (RSV), Parainfluenzavirus subtype 3 (Para 3), and Adenovirus C subtype 5 (Adeno 5). METHOD: Antiviral activity was assessed using plaque-reduction assays after adding the test substance post infection of the MDCK, HeLa and HEp-2 cells with the viruses...
2016: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Tuba Bayindir, Mustafa Iraz, Mehmet Kelles, Serdar Kaya, Mehmet Tan, Aliye Filiz, Yuksel Toplu, M Tayyar Kalcioglu
This study was undertaken to investigate the effect of betaglucan in ameliorating cisplatin ototoxicity. Rats were divided into four groups: cisplatin (C), cisplatin plus beta glucan (CB), beta glucan (B), and control (K). Distortion product otoacoustic emissions were elicited in 0th, 1st, and 5th days. For the group C differences were observed at 8,003 and 9,515 Hz between 0th and 5th days' measurements. In the group CB there were differences at frequencies of 3,996, 4,757, 5,660, and 6,726 Hz between 0th and 5th days' measurements...
June 2014: Indian Journal of Otolaryngology and Head and Neck Surgery
Rossella Di Franco, Elena Sammarco, Maria Grazia Calvanese, Flora De Natale, Sara Falivene, Ada Di Lecce, Francesca Maria Giugliano, Paola Murino, Roberto Manzo, Salvatore Cappabianca, Paolo Muto, Vincenzo Ravo
BACKGROUND AND PURPOSE: The purpose of this study was to add, to the objective evaluation, an instrumental assessment of the skin damage induced by radiation therapy. MATERIALS AND METHODS: A group of 100 patients affected by breast cancer was recruited in the study over one year. Patients were divided into five groups of 20 patients. For each group it was prescribed a different topical treatment. The following products were used: Betaglucan, sodium hyaluronate (Neoviderm®), Vitis vinifera A...
2013: Radiation Oncology
P Morganti, G Fabrizi, P Palombo, M Palombo, F Guarneri, A Cardillo, G Morganti
BACKGROUND: Nutritional and topical antioxidants and immuno-modulant compounds play a key role in maintaining healthy skin. However, little is known about the combined effects antioxidant cosmeceuticals and nutricosmetics can have on the appearance of aging skin. OBJECTIVE: The clinical trial was designed to study the combined effects on skin hydration, superficial lipids, elasticity, peroxidation and global clinical appearance, of melatonin, Vit. E and Betaglucan (MEB) complexed with chitin nano-crystals administered both topically and orally...
March 2012: Journal of Nutrition, Health & Aging
Vincenzo Ravo, Maria Grazia Calvanese, Rossella Di Franco, Vincenzina Crisci, Paola Murino, Roberto Manzo, Anna Morra, Fabrizio Cammarota, Paolo Muto
BACKGROUND AND AIMS: A minimal part of patients treated with radiotherapy on the entire breast may present an acute, subacute or chronic cutaneous damage of the healthy tissues involved in the radiation fields. The aim of this retrospective study was to evaluate the most efficient topical hydrating treatment in the prevention of cutaneous radio-induced acute effects in breast cancer. MATERIAL AND METHODS: From February 2009 to March 2010, 100 patients affected by breast cancer have been recruited, all of the female sex and with an average age of 47 years...
November 2011: Tumori
Philippe Eggimann, Jacques Bille, Oscar Marchetti
Invasive candidiasis ranges from 5 to 10 cases per 1,000 ICU admissions and represents 5% to 10% of all ICU-acquired infections, with an overall mortality comparable to that of severe sepsis/septic shock. A large majority of them are due to Candida albicans, but the proportion of strains with decreased sensitivity or resistance to fluconazole is increasingly reported. A high proportion of ICU patients become colonized, but only 5% to 30% of them develop an invasive infection. Progressive colonization and major abdominal surgery are common risk factors, but invasive candidiasis is difficult to predict and early diagnosis remains a major challenge...
2011: Annals of Intensive Care
Malcolm A Moore
The major environmental risk factors for cancer are carcinogen and co-carcinogen exposure in tobacco, insufficient exercise and above all an unhealthy diet. What we eat or do not eat is exceedingly important in determining what cancers or other chronic disease we may suffer from. Carcinogens may be integral contaminants of the diet, like nitrosamines in some situations and aflatoxins, or may be generated by cooking processes, as is known to be the case for heterocyclic amine pyrolysis products. Examples of co-carcinogenic agents may include grit in bread products, salt in pickles or betel in chewing quids...
2009: Asian Pacific Journal of Cancer Prevention: APJCP
M Rondanelli, A Opizzi, F Monteferrario
This review summarizes the recent knowledge about the positive effect of betaglucans on human health. Beta-glucans are polysaccharides occurring in the bran of cereal grains (barley and oats and to a much lesser degree in rye and wheat, in amounts of about 7%, 5%, 2% and less than 1%, respectively), the cell wall of baker's yeast, certain types of fungi, and many kinds of mushrooms. The differences between soluble and insoluble beta-glucans are significant in regards to application, mode of action, and overall biological activity...
June 2009: Minerva Medica
Wendy Yiting Chen, Esteban Marcellin, Jacky Hung, Lars Keld Nielsen
The molecular weight of hyaluronan is important for its rheological and biological function. The molecular mechanisms underlying chain termination and hence molecular weight control remain poorly understood, not only for hyaluronan synthases but also for other beta-polysaccharide synthases, e.g. cellulose, chitin, and 1,3-betaglucan synthases. In this work, we manipulated metabolite concentrations in the hyaluronan pathway by overexpressing the five genes of the hyaluronan synthesis operon in Streptococcus equi subsp...
July 3, 2009: Journal of Biological Chemistry
S Liatis, P Tsapogas, E Chala, C Dimosthenopoulos, K Kyriakopoulos, E Kapantais, N Katsilambros
AIM: Previous studies have shown that the water-soluble dietary fibre betaglucan, a natural component of oats, reduces cholesterol and postprandial hyperglycaemia. The aim of the present study was to investigate the effect of betaglucan-enriched bread consumption on the lipid profile and glucose homoeostasis of patients with type 2 diabetes (T2D). METHODS: We conducted a randomized, double-blind study in which 46 patients with T2D and LDL-C greater than 3.37 mmol/l (130 mg/dl) were randomized to incorporate into their diet, for 3 weeks, either bread enriched with betaglucan (providing 3g/day of betaglucan) or white bread without betaglucan...
April 2009: Diabetes & Metabolism
Ziba Ghasemi, Babak Farrokhi, Farah Miraghasi, Ardalan Ejaz Ahmad, Nariman Mosaffa
BACKGROUND: Polysaccharides have long been used as immune-modulators in various pathologic conditions including inflammation and solid malignancies. OBJECTIVE: To evaluate the effects of Zymosan and Betaglucan on cytotoxic reactions in an effector-target conjugate system. METHODS: Blood was obtained from 20 healthy subjects; purified mononuclear leukocytes (monocytes and lymphocytes) were extracted and cultured as effector cells by a cytotoxic method...
September 2006: Iranian Journal of Immunology: IJI
Paolo Mezzana
Nonablative skin rejuvenation using laser, intense pulsed lights (IPLs), or radiofrequency techniques are becoming increasingly popular. In this paper, a novel protocol that integrates IPL sessions, low intense light and vitamin C, low-weight hyaluronic acid, betaglucan dermal injection versus IPL photorejuvenation as monotherapy is compared. A group of 100 patients, all women, with ages ranging from 35 to 65 years old (median age 56.3) with different degrees of photodamage was considered. A blinded control study was done...
April 2008: Lasers in Medical Science
D J Jenkins, C W Kendall, M Axelsen, L S Augustin, V Vuksan
Viscous fibres such as guar, glucomannans, pectins, oat betaglucan and psyllium continue to be seen as hypocholesterolaemic. Nevertheless, in large cohort studies, ironically it is the insoluble cereal fibre that has been demonstrated to relate negatively to cardiovascular disease and diabetes, despite an absence of effect on fasting lipids or postprandial glycaemia. In general, resistant or nonabsorbable starch is lipid neutral, whereas some nonabsorbable sugars or oligosaccharides may raise serum cholesterol, possibly through providing more acetate after colonic fermentation by colonic microflora...
February 2000: Current Opinion in Lipidology
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