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https://www.readbyqxmd.com/read/28226258/a-new-hypervolume-approach-for-assessing-environmental-risks
#1
Denys Yemshanov, Frank H Koch, Bo Lu, Ronald Fournier, Gericke Cook, Jean J Turgeon
Assessing risks of uncertain but potentially damaging events, such as environmental disturbances, disease outbreaks and pest invasions, is a key analytical step that informs subsequent decisions about how to respond to these events. We present a continuous risk measure that can be used to assess and prioritize environmental risks from uncertain data in a geographical domain. The metric is influenced by both the expected magnitude of risk and its uncertainty. We demonstrate the approach by assessing risks of human-mediated spread of Asian longhorned beetle (ALB, Anoplophora glabripennis) in Greater Toronto (Ontario, Canada)...
February 19, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28226222/computer-simulations-of-intrinsically-disordered-proteins
#2
Song-Ho Chong, Prathit Chatterjee, Sihyun Ham
The investigation of intrinsically disordered proteins (IDPs) is a new frontier in structural and molecular biology that requires a new paradigm to connect structural disorder to function. Molecular dynamics simulations and statistical thermodynamics potentially offer ideal tools for atomic-level characterizations and thermodynamic descriptions of this fascinating class of proteins that will complement experimental studies. However, IDPs display sensitivity to inaccuracies in the underlying molecular mechanics force fields...
February 6, 2017: Annual Review of Physical Chemistry
https://www.readbyqxmd.com/read/28226038/filial-care-and-the-relationship-with-the-elderly-in-families-of-different-nationalities
#3
Jossiana Wilke Faller, Adriana Zilly, Angela Maria Alvarez, Sonia Silva Marcon
Objective: identify how filial care and the relationship with the elderly occur in families of different nationalities. Method: qualitative study carried out in a town on the triple frontier of Paraná, comprising 33 elderly people of five different nationalities, adopting the Symbolic Interactionism and the Grounded Theory as theoretical-methodological strategy. Results: among Lebanese people, the Muslim religion teaches children to obey and respect parents; among French, distant family relationships and institutions for the elderly stand out...
January 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28225731/queer-frontiers-in-medicine-a-structural-competency-approach
#4
Cameron A Donald, Sayantani DasGupta, Jonathan M Metzl, Kristen L Eckstrand
In 2014, the Association of American Medical Colleges (AAMC) published a report proposing qualifiers of competence to guide medical educators towards training physicians to appropriately care for individuals who are or may be lesbian, gay, bisexual, transgender (LGBT); gender nonconforming (GNC); and/or born with differences in sex development (DSD). These qualifiers provide content and context to an existing framework heavily used in competency-based medical education, emphasizing individual and interpersonal abilities to enhance care delivered to individuals identifying as LGBT, GNC, and/or born with DSD...
March 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28225619/charge-transfer-induced-para-selective-sp2-c-h-bond-activation-of-arenes-by-use-of-a-hypervalent-iodine-compound-a-theoretical-study
#5
Jiyang Zhao, Shuhua Li
The reaction mechanism of the C-H bond activation of toluene promoted by the hypervalent iodine compound TIPP-I(OH)OTs was investigated in detail by density functional theory calculations. Our calculations show that a plausible reaction pathway of the C-H bond activation of toluene contains two stages: (1) the ligand exchange process on TIPP-I(OH)OTs, involving the substitution of the hydroxyl group and tosyloxyl group with TfOH; (2) the C-H bond activation of toluene promoted by the hypervalent iodine center with the assistance of the triflate anion...
February 22, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28225614/synthesis-of-quinoidal-fused-oligosiloles-by-rhodium-catalyzed-stitching-reaction-and-theoretical-investigation-of-their-properties
#6
Ryo Shintani, Nana Misawa, Tomohiro Tsuda, Ryo Iino, Mikiya Fujii, Koichi Yamashita, Kyoko Nozaki
New quinoidal fused oligosiloles containing even-number silole units have been synthesized by a rhodium-catalyzed stitching reaction. By employing [RhCl(tfb)]2 as the catalyst, the stitching efficiency was significantly improved, and up to six siloles could be fused in a quinoidal form. Through the systematic comparison of Si1-Si6' in their physical properties, the unique trend in their LUMO levels has been confirmed, which become higher with longer pi-conjugation. To understand the origin of this unusual trend, theoretical calculations have also been carried out using various model compounds, and the results indicated that the terminal indenylidene (cyclopentadienylidene) moieties in Si1-Si6 (Si1a-Si6a) are primarily responsible for this phenomenon through their frontier orbital correlations with the HOMO of the central polyene unit, which becomes higher with longer conjugation...
February 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28225441/big-data-more-than-just-big-and-more-than-just-data
#7
Gregory A Spencer
According to an report, 90 percent of the data in the world today were created in the past two years. This statistic is not surprising given the explosion of mobile phones and other devices that generate data, the Internet of Things (e.g., smart refrigerators), and metadata (data about data). While it might be a stretch to figure out how a healthcare organization can use data generated from an ice maker, data from a plethora of rich and useful sources, when combined with an organization's own data, can produce improved results...
January 2017: Frontiers of Health Services Management
https://www.readbyqxmd.com/read/28225342/outcomes-from-the-first-multidrug-resistant-tuberculosis-programme-in-kenya
#8
H Huerga, M Bastard, M Kamene, S Wanjala, A Arnold, N Oucho, I Chikwanha, F Varaine
SETTING: In March 2006, the first multidrug-resistant tuberculosis (MDR-TB) treatment programme was implemented in Kenya. OBJECTIVE: To describe patients' treatment outcomes and adverse events. DESIGN: A retrospective case note review of patients started on MDR-TB treatment at two Médecins Sans Frontières-supported sites and the national referral hospital of Kenya was undertaken. Sites operated an ambulatory model of care. Patients were treated for a minimum of 24 months with at least 4-5 drugs for the intensive phase of treatment, including an injectable agent...
March 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28224734/anxiety-genetics-dispatches-from-the-frontier
#9
Jordan W Smoller
Anxiety disorders are the most common class of psychiatric disorders and incur an enormous burden in terms of economic costs, disability and personal suffering. Despite their public health importance and documented heritability, genetic research aimed at identifying the genetic contributions to these disorders has had limited success, particularly in comparison to recent advances in the genetics of other major psychiatric disorders. The major factor contributing to this lagging progress has been a dearth of well-powered genomic studies...
March 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28224730/the-concept-of-crosstalk-directed-embryological-target-mining-and-its-application-to-essential-hypertension-treatment-failures
#10
REVIEW
Alan Alper Sag, Oguzhan Sal, Yagmur Kilic, Emine Meltem Onal, Mehmet Kanbay
This review aims to introduce the novel concept of embryological target mining applied to interorgan crosstalk network genesis, and applies embryological target mining to multidrug-resistant essential hypertension (a prototype, complex, undertreated, multiorgan systemic syndrome) to uncover new treatment targets and critique why existing strategies fail. Briefly, interorgan crosstalk pathways represent the next frontier for target mining in molecular medicine. This is because stereotyped stepwise organogenesis presents a unique opportunity to infer interorgan crosstalk pathways that may be crucial to discovering novel treatment targets...
February 21, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28224308/a-methodological-proposal-to-evaluate-the-cost-of-duration-moral-hazard-in-workplace-accident-insurance
#11
Ángel Martín-Román, Alfonso Moral
The cost of duration moral hazard in workplace accident insurance has been amply explored by North-American scholars. Given the current context of financial constraints in public accounts, and particularly in the Social Security system, we feel that the issue merits inquiry in the case of Spain. The present research posits a methodological proposal using the econometric technique of stochastic frontiers, which allows us to break down the duration of work-related leave into what we term "economic days" and "medical days"...
February 21, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28224148/hypercrosslinked-porous-polymer-materials-design-synthesis-and-applications
#12
REVIEW
Liangxiao Tan, Bien Tan
Hypercrosslinked polymers (HCPs) are a series of permanent microporous polymer materials initially reported by Davankov, and have received an increasing level of research interest. In recent years, HCPs have experienced rapid growth due to their remarkable advantages such as diverse synthetic methods, easy functionalization, high surface area, low cost reagents and mild operating conditions. Judicious selection of monomers, appropriate length crosslinkers and optimized reaction conditions yielded a well-developed polymer framework with an adjusted porous topology...
February 22, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28222673/editorial-descriptor-spaces-for-qsar-delving-into-the-history-of-the-expanding-frontier
#13
EDITORIAL
Subhash C Basak, Rama K Mishra
No abstract text is available yet for this article.
2017: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/28220677/toward-a-sociology-of-oceans
#14
John Hannigan
Despite covering around 70 percent of the earth's surface, the ocean has long been ignored by sociology or treated as merely an extension of land-based systems. Increasingly, however, oceans are assuming a higher profile, emerging both as a new resource frontier, a medium for geopolitical rivalry and conflict, and a unique and threatened ecological hot spot. In this article, I propose a new sociological specialty area, the "sociology of oceans" to be situated at the interface between environmental sociology and traditional maritime studies...
February 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28220478/frontiers-in-otolith-chemistry-insights-advances-and-applications
#15
EDITORIAL
B D Walther, K E Limburg, C M Jones, J J Schaffler
No abstract text is available yet for this article.
February 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28220105/acth-receptor-mc2r-specificity-what-do-we-know-about-underlying-molecular-mechanisms
#16
REVIEW
Davids Fridmanis, Ance Roga, Janis Klovins
Coincidentally, the release of this Research Topic in Frontiers in Endocrinology takes place 25 years after the discovery of the adrenocorticotropic hormone receptor (ACTHR) by Mountjoy and colleagues. In subsequent years, following the discovery of other types of mammalian melanocortin receptors (MCRs), ACTHR also became known as melanocortin type 2 receptor (MC2R). At present, five types of MCRs have been reported, all of which share significant sequence similarity at the amino acid level, and all of which specifically bind melanocortins (MCs)-a group of biologically active peptides generated by proteolysis of the proopiomelanocortin precursor...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28219278/stem-cell-dialogues-a-philosophical-and-scientific-inquiry-into-medical-frontiers
#17
Matt James
No abstract text is available yet for this article.
April 2016: New Bioethics: a Multidisciplinary Journal of Biotechnology and the Body
https://www.readbyqxmd.com/read/28219243/light-induced-radical-formation-and-isomerization-of-an-aromatic-thiol-in-solution-followed-by-time-resolved-x-ray-absorption-spectroscopy-at-the-sulfur-k-edge
#18
Miguel Ochmann, Inga von Ahnen, Amy A Cordones, Abid Hussain, Jae Hyuk Lee, Kiryong Hong, Katrin Adamczyk, Oriol Vendrell, Tae Kyu Kim, Robert William Schoenlein, Nils Huse
We applied time-resolved sulfur-1s absorption spectroscopy to a model aromatic thiol system as a promising method for tracking chemical reactions in solution. Sulfur-1s absorption spectroscopy allows tracking multiple sulfur species with a time-resolution of ~70 ps. Experimental transient spectra combined with high-level electronic structure theory allow precise identification of a radical and two thione isomers, which are generated upon illumination with 267 nm radiation. Moreover, the regioselectivity of the thione isomerization is explained by resulting radical frontier orbitals...
February 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28217791/alkynyl-protected-gold-and-gold-silver-nanoclusters
#19
Zhen Lei, Xian-Kai Wan, Shang-Fu Yuan, Jia-Qi Wang, Quan-Ming Wang
Ligand-protected metal nanoclusters as unique nanomaterials have attracted great attention. The protecting ligands that directly bind on the cluster surfaces are crucial in dictating the structures and properties of the clusters. In contrast to the extensively studied thiolates, alkynyl ligands have been found recently to be important ligands for passivating gold/silver cluster surfaces. In this Frontier article, recent advances in alkynyl-protected metal nanoclusters are overviewed, and the structures, luminescence and catalytic activities are also discussed...
February 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28216729/aerospace-dermatology
#20
Gp Capt Sandeep Arora
Evolutionarily, man is a terrestrial mammal, adapted to land. Aviation and now space/microgravity environment, hence, pose new challenges to our physiology. Exposure to these changes affects the human body in acute and chronic settings. Since skin reflects our mental and physical well-being, any change/side effects of this environment shall be detected on the skin. Aerospace industry offers a unique environment with a blend of all possible occupational disorders, encompassing all systems of the body, particularly the skin...
January 2017: Indian Journal of Dermatology
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