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https://www.readbyqxmd.com/read/27926620/tapping-magnet%C3%A2-s-culture-of-innovation-to-improve-the-patient-experience
#1
Jennifer Rainer
As incentives grow for healthcare organizations to improve the patient experience, an increasing number choose to add consumers directly into their leadership structures. In this final installment about the value of patient and family advisory councils, the senior director of quality at a large, Magnet®-recognized Texas hospital explains how tapping into a well-established Magnet culture helped the organization adopt innovative approaches that produced positive change. Based on an interview with the author, she notes that seeing basic issues through patients' eyes challenged long-held beliefs and led to improvements in a wide variety of areas...
January 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/27923797/is-myocardial-fibrosis-a-new-frontier-for-discovery-in-cardiotoxicity-related-to-the-administration-of-anthracyclines
#2
EDITORIAL
Giselle C Meléndez, W Gregory Hundley
No abstract text is available yet for this article.
December 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27921381/cost-analysis-of-the-treatment-of-severe-acute-malnutrition-in-west-africa
#3
Sheila Isanaka, Nicolas A Menzies, Jessica Sayyad, Mudasiru Ayoola, Rebecca F Grais, Stéphane Doyon
We present an updated cost analysis to provide new estimates of the cost of providing community-based treatment for severe acute malnutrition, including expenditure shares for major cost categories. We calculated total and per child costs from a provider perspective. We categorized costs into three main activities (outpatient treatment, inpatient treatment, and management/administration) and four cost categories within each activity (personnel; therapeutic food; medical supplies; and infrastructure and logistical support)...
December 5, 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/27920893/antibody-drug-conjugates-and-other-nanomedicines-the-frontier-of-gynaecological-cancer-treatment
#4
REVIEW
David Howard, Jetzabel Garcia-Parra, Gareth D Healey, Cynthia Amakiri, Lavinia Margarit, Lewis W Francis, Deyarina Gonzalez, R Steven Conlan
Gynaecological cancers: malignancies of the cervix, uterus, ovaries, vagina and vulva, are responsible for over 1.1 million new cancer cases and almost half a million deaths annually. Ovarian cancer in particular is difficult to treat due to often being diagnosed at a late stage, and the incidence of uterine and vulvar malignancies are both on the rise. The field of nanomedicine is beginning to introduce drugs into the clinic for oncological applications exemplified by the liposomal drugs, Doxil and Myocet, the nanoparticle, Abraxane and antibody-drug conjugates (ADCs), Kadcyla and Adcetris...
December 6, 2016: Interface Focus
https://www.readbyqxmd.com/read/27918440/a-computational-study-of-structure-and-reactivity-of-n-substitued-4-piperidones-curcumin-analogues-and-their-radical-anions
#5
Maximiliano Martínez-Cifuentes, Boris Weiss-López, Ramiro Araya-Maturana
In this work, a computational study of a series of N-substitued-4-piperidones curcumin analogues is presented. The molecular structure of the neutral molecules and their radical anions, as well as their reactivity, are investigated. N-substituents include methyl and benzyl groups, while substituents on the aromatic rings cover electron-donor and electron-acceptor groups. Substitutions at the nitrogen atom do not significantly affect the geometry and frontier molecular orbitals (FMO) energies of these molecules...
December 2, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27917308/history-of-botulinum-toxin-treatment-in-movement-disorders
#6
REVIEW
Bahman Jabbari
BACKGROUND: The frontiers of clinical medicine constantly expand as a result of the innovative efforts of visionary researchers and keen observations of seasoned clinicians. In medicine, rarely has a therapeutic agent been found efficacious in the management of so many symptoms and in such a relatively short time as botulinum toxin. One of the most notable contributions of botulinum toxin therapy in clinical medicine is in the field of movement disorders. METHODS: The English literature was searched using the Yale search engine including but not limited to PubMed and Ovid...
2016: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/27916437/animal-testing-is-still-the-best-way-to-find-new-treatments-for-patients
#7
Silvio Garattini, Giuliano Grignaschi
Experimental research proceeds by hypotheses formulated on the basis of previous or new knowledge and then tested. If they are accepted, they serve as the basis for further hypotheses, and if they are rejected new hypotheses can be developed. In other words, when we are at the frontiers of knowledge the path is forged by "trial and error". When a trial shows a hypothesis is wrong, this is a step toward making fewer errors. This process also applies to drug development. There is no magic formula at present to predict - at the pre-clinical level - the therapeutic value of a drug for people with a disease...
December 1, 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27914058/osprey-predicts-resistance-mutations-using-positive-and-negative-computational-protein-design
#8
Adegoke Ojewole, Anna Lowegard, Pablo Gainza, Stephanie M Reeve, Ivelin Georgiev, Amy C Anderson, Bruce R Donald
Drug resistance in protein targets is an increasingly common phenomenon that reduces the efficacy of both existing and new antibiotics. However, knowledge of future resistance mutations during pre-clinical phases of drug development would enable the design of novel antibiotics that are robust against not only known resistant mutants, but also against those that have not yet been clinically observed. Computational structure-based protein design (CSPD) is a transformative field that enables the prediction of protein sequences with desired biochemical properties such as binding affinity and specificity to a target...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27913463/single-dose-intravenous-iron-for-iron-deficiency-a-new-paradigm
#9
Michael Auerbach, Thomas Deloughery
Iron-deficiency anemia is the most common hematologic problem in the world. Although oral iron is often viewed as front-line therapy, extensive published evidence has accumulated that IV iron is superior, in both efficacy and safety, to oral iron in many clinical situations and should be introduced much sooner in the treatment paradigm of iron-deficient patients. In this chapter, we will review the formulations of IV iron that allow total complete replacement doses in 1 or 2 sessions including practical tips for administration...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27911885/ambient-pressure-photoelectron-spectroscopy-practical-considerations-and-experimental-frontiers
#10
Lena Trotochaud, Ashley R Head, Osman Karslıoğlu, Line Kyhl, Hendrik Bluhm
Over the past several decades, ambient pressure x-ray photoelectron spectroscopy (APXPS) has emerged as a powerful technique for in situ and operando investigations of chemical reactions under relevant ambient atmospheres far from ultra-high vacuum conditions. This review focuses on exemplary cases of APXPS experiments, giving special consideration to experimental techniques, challenges, and limitations specific to distinct condensed matter interfaces. We discuss APXPS experiments on solid/vapor interfaces, including the special case of 2D films of graphene and hexagonal boron nitride on metal substrates with intercalated gas molecules, liquid/vapor interfaces, and liquid/solid interfaces, which are a relatively new class of interfaces being probed by APXPS...
December 2, 2016: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/27911120/new-frontiers-in-anticoagulation-non-vitamin-k-oral-anticoagulants-in-stroke-prevention
#11
Valentina Arnao, Marianna Riolo, Antonino Tuttolomondo, Antonio Pinto, Brigida Fierro, Paolo Aridon
Non vitamin-K oral anticoagulants (NOACs) are direct and specific inhibitors of the coagulation factors IIa (dabigatran) and Xa (apixaban, rivaroxaban, edoxaban) which share many pharmacokinetic properties. However, indications are lacking regarding the use of NOACs during thrombolysis, surgery and bleeding events. Areas covered: In this paper, the authors retrospectively analyzed the relevant literature on the NOACs using the PubMed and Google Scholar databases. Expert Commentary: Although warfarin is effective in cardioembolic stroke prevention, easier handling and more favorable risk-benefit profile often render NOACs a more preferable therapy choice for neurologists...
December 2, 2016: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/27911113/a-tribute-to-professor-steven-l-wechsler-1948-2016-the-man-and-the-scientist
#12
Anthony B Nesburn, Lbachir BenMohamed
Professor Steven L. Wechsler, a world-renowned eye researcher and virologist, passed away unexpectedly on June 12, 2016 at the age of 68. Many scientists came to know Professor Wechsler as a gifted researcher in the field of ocular Herpes Simplex Virus (HSV-1) latency, reactivation, and pathogenesis. Professor Wechsler published over 150 peer-reviewed scientific papers during his career, pushing forward the frontiers of his field eye research. His colleagues would say, 'Steve literally wrote the book on herpes latency and reactivation...
December 2, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27908522/small-intestine-exploring-the-last-great-frontier-for-gastrointestinal-endoscopy
#13
EDITORIAL
Charles J Lightdale
No abstract text is available yet for this article.
January 2017: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/27905546/transcriptome-analysis-confers-a-complex-disease-resistance-network-in-wild-rice-oryza-meyeriana-against-xanthomonas-oryzae-pv-oryzae
#14
Xiao-Jie Cheng, Bin He, Lin Chen, Su-Qin Xiao, Jian Fu, Yue Chen, Teng-Qiong Yu, Zai-Quan Cheng, Hong Feng
Rice bacterial blight (BB), caused by Xanthomonas oryzae pv. oryzae (Xoo), is one of the devastating diseases of rice. It is well established that the wild rice Oryza meyeriana is immune to BB. In this study, the transcriptomic analysis was carried out by RNA sequencing of O. meyeriana leaves, inoculated with Xoo to understand the transcriptional responses and interaction between the host and pathogen. Totally, 57,313 unitranscripts were de novo assembled from 58.7 Gb clean reads and 14,143 unitranscripts were identified after Xoo inoculation...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27903769/education-for-the-next-frontier-in-patient-safety-a-longitudinal-resident-curriculum-on-diagnostic-error
#15
Emily Ruedinger, Maren Olson, Justin Yee, Emily Borman-Shoap, Andrew P J Olson
Diagnostic error is a common, serious problem that has received increased attention recently for its impact on both patients and providers. Presently, most graduate medical education programs do not formally address this topic. The authors developed and evaluated a longitudinal, multimodule resident curriculum about diagnostic error and medical decision making. Key components of the curriculum include demystifying the medical decision-making process, building skills in critical thinking, and providing strategies for diagnostic error mitigation...
November 29, 2016: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/27901014/stacked-antiaromatic-porphyrins
#16
Ryo Nozawa, Hiroko Tanaka, Won-Young Cha, Yongseok Hong, Ichiro Hisaki, Soji Shimizu, Ji-Young Shin, Tim Kowalczyk, Stephan Irle, Dongho Kim, Hiroshi Shinokubo
Aromaticity is a key concept in organic chemistry. Even though this concept has already been theoretically extrapolated to three dimensions, it usually still remains restricted to planar molecules in organic chemistry textbooks. Stacking of antiaromatic π-systems has been proposed to induce three-dimensional aromaticity as a result of strong frontier orbital interactions. However, experimental evidence to support this prediction still remains elusive so far. Here we report that close stacking of antiaromatic porphyrins diminishes their inherent antiaromaticity in the solid state as well as in solution...
November 30, 2016: Nature Communications
https://www.readbyqxmd.com/read/27900379/a-theoretical-study-on-the-unusual-square-planar-structure-of-bis-imino-pyridine-ligated-group-13-complexes
#17
Weiyi Li, Yajing Lyu, Huifang Zhang, Maoqin Zhu, Hanping Tang
The unusual square-planar (SP) structure of four-coordinate Al(III)-complexes with the phenyl-substituted tridentate bis(imino)pyridine ((Ph)I2P) ligand has been studied by a combination of density functional theory (DFT) calculations, frontier molecule orbital (FMO), nucleus-independent chemical shift (NICS) and strain/interaction analyses. The calculations disclose that: (i) the aromaticity shifting from the pyridine ring to the alumina-imidazolate metallacycle, and (ii) the small strain energy imposed on the ligand backbone are two favourable factors for driving the overall SP coordination of the Al(III) ion...
November 30, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27897285/magnetic-coupling-in-a-hybrid-mn-ii-acetylene-dicarboxylate
#18
Christopher H Hendon, Fabienne Pradaux-Caggiano, Lauren E Hatcher, William J Gee, Chick C Wilson, Keith T Butler, David R Carbery, Aron Walsh, Brent C Melot
The design of ligands that mediate through-bond long range super-exchange in metal-organic hybrid materials would expand chemical space beyond the commonly observed short range, low temperature magnetic ordering. Here we examine acetylene dicarboxylate as a potential ligand that could install long range magnetic ordering due to its spatially continuous frontier orbitals. Using a known Mn(ii)-containing coordination polymer we compute and measure the electronic structure and magnetic ordering. In this case, the latter is weak owing to the sub-optimal ligand coordination geometry, with a critical temperature of 2...
November 29, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27894124/extensive-degeneracy-coulomb-phase-and-magnetic-monopoles-in-artificial-square-ice
#19
Yann Perrin, Benjamin Canals, Nicolas Rougemaille
Artificial spin-ice systems are lithographically patterned arrangements of interacting magnetic nanostructures that were introduced as way of investigating the effects of geometric frustration in a controlled manner. This approach has enabled unconventional states of matter to be visualized directly in real space, and has triggered research at the frontier between nanomagnetism, statistical thermodynamics and condensed matter physics. Despite efforts to create an artificial realization of the square-ice model-a two-dimensional geometrically frustrated spin-ice system defined on a square lattice-no simple geometry based on arrays of nanomagnets has successfully captured the macroscopically degenerate ground-state manifold of the model...
November 28, 2016: Nature
https://www.readbyqxmd.com/read/27892559/insights-into-bonding-interactions-and-excitation-energies-of-3d-4f-mixed-lanthanide-transition-metal-macrocyclic-complexes
#20
Walter A Rabanal-León, Juliana A Murillo-López, Ramiro Arratia-Pérez
In this contribution, a computational study of equatorial bound tetranuclear macrocycle (butylene linked) [LnZn(HOM(Bu))](3+) (Ln = La(3+), Ce(3+)) complexes was carried out. Here, the electronic structure, bonding interaction and excitation energies were studied within the relativistic density functional theory framework. From the electronic structure analysis, the frontier molecular orbitals (FMOs) were strongly localized in the d-orbitals of the Zn centers and the f-orbitals of the lanthanide ions. Besides, the inner MOs were found to exhibit a π-character from the organic part of the macrocyclic chain...
November 28, 2016: Physical Chemistry Chemical Physics: PCCP
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