Read by QxMD icon Read


Henry H Wilson, Connor A Koellner, Zain M Hannan, Caroline B Endy, Mark W Bezpalko, Nicholas A Piro, W Scott Kassel, Matthew D Sonntag, Christopher R Graves
The synthesis and full characterization of a series of neutral ligand α-diimine complexes of aluminum are reported. The compounds [Al(LAr )2 Cl2 )][AlCl4 ] [LAr = N, N'-bis(4-R-C6 H4 )-2,3-dimethyl-1,4-diazabutadiene] are structurally analogous, as determined by multinuclear NMR spectroscopy and solid-state X-ray diffraction, across a range of electron-donating [R = Me (2),t Bu (3), OMe (4), and NMe2 (5)] and electron-withdrawing [R = Cl (6), CF3 (7), and NO2 (8)] substituents in the aryl side arm of the ligand...
March 19, 2018: Inorganic Chemistry
Katya B Rubinow
BACKGROUND: Over the past two decades, parallel recognition has grown of the importance of both sex steroids and immune activity in metabolic regulation. More recently, these discrete areas have been integrated in studies examining the metabolic effects of sex steroid immunomodulation. Implicit in these studies has been a traditional, endocrine model of sex steroid delivery from the gonads to target cells, including immune cells. Thus, research to date has focused on the metabolic effects of sex steroid receptor signaling in immune cells...
March 8, 2018: Molecular Metabolism
Pete Buth, Benoit de Gryse, Sean Healy, Vincent Hoedt, Tara Newell, Giovanni Pintaldi, Hernan Del Valle, Julian C Sheather, Sidney Wong
Humanitarian organisations often work alongside those responsible for serious wrongdoing. In these circumstances, accusations of moral complicity are sometimes levelled at decision makers. These accusations can carry a strong if unfocused moral charge and are frequently the source of significant moral unease. In this paper, we explore the meaning and usefulness of complicity and its relation to moral accountability. We also examine the impact of concerns about complicity on the motivation of humanitarian staff and the risk that complicity may lead to a retreat into moral narcissism...
March 17, 2018: Journal of Medical Ethics
M Moreno, A Zacarias, A Porzel, L Velasquez, G Gonzalez, M Alegría-Arcos, F Gonzalez-Nilo, E K U Gross
Emerging and re-emerging epidemic diseases pose an ongoing threat to global health. Currently, Enterobactin and Enterobactin derivatives have gained interest, owing to their potential application in the pharmaceutical field. As it is known [J. Am. Chem. Soc (1979) 101, 20, 6097-6104], Enterobactin (H6 EB) is an efficient iron carrier synthesized and secreted by many microbial species. In order to facilitate the elucidation of enterobactin and its analogues, here we propose the creation of a H6 EB standard set using Density Functional Theory Infrared (IR) and NMR spectra...
March 2, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Zachary Js Mays, Nikhil U Nair
The trillions of microbes hosted by humans can dictate health or illness depending on a multitude of genetic, environmental, and lifestyle factors that help define the human ecosystem. As the human microbiota is characterized, so can the interconnectivity of microbe-host-disease be realized and manipulated. Designing microbes as therapeutic agents can not only enable targeted drug delivery but also restore homeostasis within a perturbed microbial community. Used for centuries in fermentation and preservation of food, lactic acid bacteria (LAB) have a long history of safe, and occasionally health promoting, interactions with the human gut, making them ideal candidates for engineered functionality...
March 15, 2018: Current Opinion in Biotechnology
A V Belyaev, J L Dunster, J M Gibbins, M A Panteleev, V Volpert
Hemostasis is a complex physiological mechanism that functions to maintain vascular integrity under any conditions. Its primary components are blood platelets and a coagulation network that interact to form the hemostatic plug, a combination of cell aggregate and gelatinous fibrin clot that stops bleeding upon vascular injury. Disorders of hemostasis result in bleeding or thrombosis, and are the major immediate cause of mortality and morbidity in the world. Regulation of hemostasis and thrombosis is immensely complex, as it depends on blood cell adhesion and mechanics, hydrodynamics and mass transport of various species, huge signal transduction networks in platelets, as well as spatiotemporal regulation of the blood coagulation network...
March 5, 2018: Physics of Life Reviews
Mohammed Dalwai, Katie Tayler-Smith, Michèle Twomey, Masood Nasim, Abdul Qayum Popal, Waliul Haq Haqdost, Olivia Gayraud, Sophia Cheréstal, Lee Wallis, Pola Valles
OBJECTIVE: The South African Triage Scale (SATS) has demonstrated good validity in the EDs of Médecins Sans Frontières (MSF)-supported sites in Afghanistan and Haiti; however, corresponding reliability in these settings has not yet been reported on. This study set out to assess the inter-rater and intrarater reliability of the SATS in four MSF-supported EDs in Afghanistan and Haiti (two trauma-only EDs and two mixed (including both medical and trauma cases) EDs). METHODS: Under classroom conditions between December 2013 and February 2014, ED nurses at each site assigned triage ratings to a set of context-specific vignettes (written case reports of ED patients)...
March 16, 2018: Emergency Medicine Journal: EMJ
Valérie Haydont, Bruno A Bernard, Nicolas O Fortunel
Ageing is today a major societal concern that is intrinsically associated with the increase of life expectancy. Outside the context of severe degenerative diseases that affect the elderly populations, normal visible signs of ageing, notably skin sagging and wrinkles, influence the social and individual perception of peoples. Accordingly, there is a strong demand for researches on skin ageing. Deciphering the cellular and molecular processes of skin evolution through ageing is thus an active scientific domain, at the frontier of tissue developmental and ageing biology...
March 13, 2018: Mechanisms of Ageing and Development
Shinichiro Ohshimo, Ulrich Costabel, Nobuaki Shime
No abstract text is available yet for this article.
March 2018: Respiratory Investigation
Anne C Conibear, Markus Muttenthaler
The 7th Chemical Protein Synthesis Meeting took place in September 2017 in Haifa, Israel, bringing together 100 scientists from 11 countries. The cutting-edge scientific program included new synthetic strategies and ligation auxiliaries, novel insights into protein signaling and post-translational modifications, and a range of promising therapeutic applications.
March 15, 2018: Cell Chemical Biology
Li-Hui Mou, Qing-Yu Liu, Ting Zhang, Zi-Yu Li, Sheng-Gui He
Dinitrogen activation/fixation is one of the most important and challenging subjects in synthetic as well as theoretical chemistry. In this study, the adsorption reactions of N2 onto TaCn - ( n = 1-4) cluster anions have been investigated by means of mass spectrometry in conjunction with density functional theory calculations. Following the experimental results that only TaC4 - was observed to adsorb N2 , theoretical calculations predicted that TaC4 - reaction system (TaC4 - + N2 → TaC4 N2 - ) has a negligible barrier on the approach of N2 molecule while insurmountable barriers are located on the reaction pathways of TaC1-3 - /N2 reaction systems...
March 16, 2018: Journal of Physical Chemistry. A
Rob Smith
Mass spectrometry is an important tool used by many scientists throughout the world. Nonetheless, feedback on the strengths and limitations of current software is often restricted to anecdote rather than formal inquiry. Over the course of 100 interviews over the state of mass spectrometry software, surprising patterns coalesced on several topics: perception of the frontier, perception of software quality, and differences between commercial and non-profit environments. Most notably, interviews suggested a substantial schism between user satisfaction with current software and developer perceptions of software quality...
March 16, 2018: Journal of Proteome Research
B A Hussein, J T Huynh, P L Prieto, C P Barran, A E Arnold, O V Sarycheva, A J Lough, B D Koivisto
BODIPY (4,4-difluoro-4-bora-3a,4a-diaza-s-indacenes) dyes possess intense absorption profiles that can be exploited in various light harvesting applications. However, redox stability and optimization of frontier molecular orbital energies in these dyes are critical for their successful incorporation into new solar cell materials. This article describes the synthesis and characterization of a family of β-substituted BODIPY-ferrocene dyads with push-pull architectures. Designed to stabilize the photo-oxidized BODIPY for dye-sensitized solar cell (DSSC) applications, some deleterious electron transfer behaviours emerged when the ferrocene unit was conjugated to electron deficient BODIPYs...
March 16, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
David Vernez, Sandrine Fraize-Frontier, Raymond Vincent, Stéphane Binet, Christophe Rousselle
OBJECTIVES: Assessment factors (AFs) are commonly used for deriving reference concentrations for chemicals. These factors take into account variabilities as well as uncertainties in the dataset, such as inter-species and intra-species variabilities or exposure duration extrapolation or extrapolation from the lowest-observed-adverse-effect level (LOAEL) to the noobserved- adverse-effect level (NOAEL). In a deterministic approach, the value of an AF is the result of a debate among experts and, often a conservative value is used as a default choice...
March 15, 2018: International Journal of Occupational Medicine and Environmental Health
Antonio Rossi, Rebecca Tay, Jaseela Chiramel, Arsela Prelaj, Raffaele Califano
Small-cell lung cancer (SCLC) is a very aggressive disease characterized by a high response rate to first-line chemotherapy, but most patients relapse within 1 year with disappointing results to second-line treatments. Chemotherapy has reached a plateau of effectiveness and new therapeutic strategies are needed to change the natural history of SCLC. Areas covered: This review will focus on the current results and the future development of the therapeutic approaches for the treatment of SCLC. Expert commentary: Immunotherapy is becoming a new frontier for the management of SCLC with preliminary interesting results...
March 15, 2018: Expert Review of Anticancer Therapy
Takashi Kumagai, Janina N Ladenthin, Yair Litman, Mariana Rossi, Leonhard Grill, Sylwester Gawinkowski, Jacek Waluk, Mats Persson
Tautomerization in single porphycene molecules is investigated on Cu(111), Ag(111), and Au(111) surfaces by a combination of low-temperature scanning tunneling microscopy (STM) experiments and density functional theory (DFT) calculations. It is revealed that the trans configuration is the thermodynamically stable form of porphycene on Cu(111) and Ag(111), whereas the cis configuration occurs as a meta-stable form. The trans → cis or cis → trans conversion on Cu(111) can be induced in an unidirectional fashion by injecting tunneling electrons from the STM tip or heating the surface, respectively...
March 14, 2018: Journal of Chemical Physics
Mariana Avalos, Gilles P van Wezel, Jos M Raaijmakers, Paolina Garbeva
Microorganisms represent a large and still resourceful pool for the discovery of novel compounds to combat antibiotic resistance in human and animal pathogens. The ability of microorganisms to produce structurally diverse volatile compounds has been known for decades, yet their biological functions and antimicrobial activities have only recently attracted attention. Various studies revealed that microbial volatiles can act as infochemicals in long-distance cross-kingdom communication as well as antimicrobials in competition and predation...
March 12, 2018: Current Opinion in Microbiology
Becky Freeman, Suzan Burton
No abstract text is available yet for this article.
March 19, 2018: Medical Journal of Australia
Shannon M Melody, Veronica Martin-Gall, Ben Harding, Mark Gk Veitch
OBJECTIVES: To describe the retail availability of tobacco and to examine the association between tobacco outlet density and area-level remoteness and socio-economic status classification in Tasmania. DESIGN: Ecological cross-sectional study; analysis of tobacco retail outlet data collected by the Department of Health and Human Services (Tasmania) according to area-level (Statistical Areas Level 2) remoteness (defined by the Remoteness Structure of the Australian Statistical Geographical Standard) and socio-economic status (defined by the 2011 Australian Bureau of Statistics Index of Relative Socioeconomic Advantage and Disadvantage)...
March 19, 2018: Medical Journal of Australia
Reza Dana
No abstract text is available yet for this article.
March 15, 2018: New England Journal of Medicine
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"