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https://www.readbyqxmd.com/read/27919146/-cancer-mortality-of-residents-near-a-steel-factory-in-udine-friuli-venezia-giulia-region-northern-italy
#1
Luigi Castriotta, Anica Casetta, Fabio Barbone
OBJECTIVES: to evaluate the association between distance of residence from a steel factory, a point source of air pollution within an industrial area in Udine (Friuli Venezia Giulia Region, Northern Italy), and cancer mortality. DESIGN: retrospective study. To evaluate the association between mortality rates and distance from the source, a Stone test analysis for all cases occurred in the entire area was conducted. The significance level was determined using Monte Carlo simulations...
November 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/27909142/disease-activity-and-increased-risk-of-cardiovascular-death-among-patients-with-psoriatic-arthritis
#2
Kristina Juneblad, Solbritt Rantapää-Dahlqvist, Gerd-Marie Alenius
OBJECTIVE: Recent studies indicate increased cardiovascular (CV) morbidity and mortality in patients with psoriatic arthritis (PsA), but results are inconsistent. This prompted our investigation of the mortality rate, cause of death, and incidence of acute CV events in patients from northern Sweden with PsA. METHODS: Patients with established PsA (464) were included. To calculate standardized mortality ratio (SMR) and standardized incidence ratio (SIR) for CV events, data were extracted from the National Causes of Death Register and the National Inpatient Care Register in Sweden, and compared with the general population...
December 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27902746/the-effect-of-intravenous-immunoglobulin-combined-with-corticosteroid-on-the-progression-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-a-meta-analysis
#3
Liang-Ping Ye, Cheng Zhang, Qi-Xing Zhu
BACKGROUND: Intravenous immunoglobulin (IVIG) treatment is commonly used to treat Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) with controversial therapeutic effect. METHODS: We conducted a comprehensive meta-analysis through combining the published eligible studies to evaluate the effectiveness of IVIG on SJS and TEN treatment. RESULTS: A total of 26 studies were selected from public available databases. The combination of IVIG and corticosteroid markedly reduced the recovery time (by 1...
2016: PloS One
https://www.readbyqxmd.com/read/27901411/injury-mortality-in-a-cohort-of-mining-smelting-and-refining-workers-in-ontario
#4
Colin J Berriault, Nancy E Lightfoot, Steven K Seilkop, Bruce R Conard
Injury mortality was followed up from 1950 to 2000 in a cohort of 56,576 nickel workers. Injury fatalities were elevated throughout the cohort of never sinter plant workers (SMR = 134, 95% CI: 129-140). Elevations were also observed in injury mortality sub-categories of road, rail, and air (SMR = 137, 95% CI: 127-147); boating and swimming (SMR = 150, 95% CI: 128-176); suicide and possible suicide (SMR = 124, 95% CI: 114-135); and possibly job-related accidents (SMR = 160, 95% CI: 145-175). The results were largely attributed to underground miners with 61...
November 30, 2016: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/27900668/propensity-score-weighting-compared-to-matching-in-a-study-of-dabigatran-and-warfarin
#5
John D Seeger, Katsiaryna Bykov, Dorothee B Bartels, Krista Huybrechts, Sebastian Schneeweiss
INTRODUCTION: Comparing medications in observational settings requires differences in patient characteristics to be accounted for. Propensity score (PS) methods can address these differences, but PS weighting approaches may introduce bias. METHODS: Within a cohort study of anticoagulant initiators from October 2010 through to December 2012, PS values for dabigatran relative to warfarin were estimated, and study outcomes (stroke or major bleeding) among the cohort were identified...
November 29, 2016: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/27899698/illuminating-a-risk-for-breast-cancer-a-preliminary-ecological-study-on-the-association-between-streetlight-and-breast-cancer
#6
Atalya Keshet-Sitton, Keren Or-Chen, Eran Huber, Abraham Haim
Artificial light at night (ALAN) for elongating photophase is a new source of pollution. We examined the association between measured ALAN levels and breast cancer (BC) standard morbidity ratio (SMR) at a statistical area (SA) level in an urban environment. Sample size consisted of 266 new BC cases ages 35-74. Light measurements (lux) were performed in 11 SAs. A new calculated variable of morbidity per SA size (SMR35-74/km(2)) was correlated with the light variables per road length, using Pearson correlations (P < ...
November 29, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27899672/the-swiss-model-repository-new-features-and-functionality
#7
Stefan Bienert, Andrew Waterhouse, Tjaart A P de Beer, Gerardo Tauriello, Gabriel Studer, Lorenza Bordoli, Torsten Schwede
SWISS-MODEL Repository (SMR) is a database of annotated 3D protein structure models generated by the automated SWISS-MODEL homology modeling pipeline. It currently holds >400 000 high quality models covering almost 20% of Swiss-Prot/UniProtKB entries. In this manuscript, we provide an update of features and functionalities which have been implemented recently. We address improvements in target coverage, model quality estimates, functional annotations and improved in-page visualization. We also introduce a new update concept which includes regular updates of an expanded set of core organism models and UniProtKB-based targets, complemented by user-driven on-demand update of individual models...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27897234/association-between-dioxin-and-cancer-incidence-and-mortality-a-meta-analysis
#8
Jinming Xu, Yao Ye, Fang Huang, Hanwen Chen, Han Wu, Jian Huang, Jian Hu, Dajing Xia, Yihua Wu
The objective of the present study was to systematically assess the association between dioxin/2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and cancer incidence and mortality. Systematic literature searches were conducted until July 2015 in Pubmed, Embase and Cochrane library to identify relevant studies. A random-effects model was applied to estimate the pooled odds ratio (OR), risk ratio (RR), standard incidence ratio (SIR) or standard mortality ratio (SMR) for cancer incidence or mortality. In addition, dose-response, meta-regression, subgroup, and publication bias analyses were conducted...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27896676/what-is-the-incidence-of-suicide-in-patients-with-bone-and-soft-tissue-cancer-suicide-and-sarcoma
#9
Brianna L Siracuse, George Gorgy, Jeremy Ruskin, Kathleen S Beebe
BACKGROUND: Patients with cancer in the United States are estimated to have a suicide incidence that is approximately twice that of the general population. Patients with bone and soft tissue cancer often have physical impairments and activity limitations develop that reduce their quality of life, which may put them at high risk for depression, anxiety, and suicidal ideation. To our knowledge, there have been no large studies determining incidence of suicide among patients with bone and soft tissue cancer; this information might allow screening of certain high-risk groups...
November 28, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27876056/post-universal-health-coverage-trend-and-geographical-inequalities-of-mortality-in-thailand
#10
Suchunya Aungkulanon, Viroj Tangcharoensathien, Kenji Shibuya, Kanitta Bundhamcharoen, Virasakdi Chongsuvivatwong
BACKGROUND: Thailand has achieved remarkable improvement in health status since the achievement of universal health coverage in 2002. Health equity has improved significantly. However, challenges on health inequity still remain.This study aimed to determine the trends of geographical inequalities in disease specific mortality in Thailand after the country achieved universal health coverage. METHODS: National vital registration data from 2001 to 2014 were used to calculate age-adjusted mortality rate and standardized mortality ratio (SMR)...
November 22, 2016: International Journal for Equity in Health
https://www.readbyqxmd.com/read/27875970/a-systematic-prediction-of-drug-target-interactions-using-molecular-fingerprints-and-protein-sequences
#11
Yu-An Huang, Zhu-Hong You, Xing Chen
Drug-Target Interactions (DTI) play a crucial role in discovering new drug candidates and finding new proteins to target for drug development. Although the number of detected DTI obtained by high-throughput techniques has been increasing, the number of known DTI is still limited. On the other hand, the experimental methods for detecting the interactions among drugs and proteins are costly and inefficient. Therefore, computational approaches for predicting DTI are drawing increasing attention in recent years...
November 21, 2016: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/27875220/high-quality-factor-low-temperature-dependency-smr-fbar-based-on-bst-using-mod-deposition-method
#12
Almonir Mansour, Thottam Kalkur
This paper presents the design, fabrication and experimental evaluation of switchable and tunable thin film bulk acoustic wave (BAW) resonators and filters with MOSD deposited BST for radio frequency (RF) applications. The switchability and tunability of these devices come from utilizing the electrostrictive effect of ferroelectric materials such as barium strontium titanate (BST) with the application of an external dc bias voltage. The BAW resonators and filters in this paper were fabricated on high resistivity silicon substrate as solidly mounted resonator (SMR) structure with eight layers of silicon dioxide and tantalum oxide as a Bragg reflector...
November 18, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27874920/m%C3%A3-n-har-b%C3%A3-ttre-intensivv%C3%A3-rds%C3%A2-%C3%A3-verlevnad-%C3%A3-n-kvinnor-g%C3%A3-ller-fr%C3%A3-mst-diagnoser-som-hj%C3%A3-rtstopp-och-septisk-chock
#13
Hanna Nyberg, Carolina Samuelsson, Attila Frigyesi
Better intensive care outcomes for men than women especially in septic shock and after cardiac arrest In this study 11 764 intensive care admissions to Skåne University Hospital in Sweden between 2008 and 2015 were studied for any gender differences in outcome for different diagnoses. As known from previous studies, men had more intensive care admissions and had a higher morbidity necessitating the use of risk adjusted mortality measures. Through a simple but new application of VLAD we found this risk-adjusted mortality measure to be more sensitive in detecting differences in mortality between groups than the more commonly used SMR...
November 15, 2016: Läkartidningen
https://www.readbyqxmd.com/read/27871798/the-association-of-air-pollution-and-greenness-with-mortality-and-life-expectancy-in-spain-a-small-area-study
#14
Carmen de Keijzer, David Agis, Albert Ambrós, Gustavo Arévalo, Jose M Baldasano, Stefano Bande, Jose Barrera-Gómez, Joan Benach, Marta Cirach, Payam Dadvand, Stefania Ghigo, Èrica Martinez-Solanas, Mark Nieuwenhuijsen, Ennio Cadum, Xavier Basagaña
BACKGROUND: Air pollution exposure has been associated with an increase in mortality rates, but few studies have focused on life expectancy, and most studies had restricted spatial coverage. A limited body of evidence is also suggestive for a beneficial association between residential exposure to greenness and mortality, but the evidence for such an association with life expectancy is still very scarce. OBJECTIVE: To investigate the association of exposure to air pollution and greenness with mortality and life expectancy in Spain...
November 18, 2016: Environment International
https://www.readbyqxmd.com/read/27866950/cause-specific-mortality-trends-following-total-hip-and-knee-arthroplasty
#15
Clement J Michet, Cathy D Schleck, Dirk R Larson, Hilal Maradit Kremers, Daniel J Berry, David G Lewallen
BACKGROUND: While studies have demonstrated that mortality after total hip (THA) and total knee (TKA) arthroplasty is better than the general population, the causes of death are not well established. We evaluated cause-specific mortality after THA and TKA. METHODS: The study included population-based cohorts of patients who underwent THA (N = 2019) and TKA (N = 2259) between 1969 and 2008. Causes of death were classified using the International Classification of Diseases 9th and 10th editions...
October 20, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27831506/causes-of-death-among-cancer-patients
#16
N G Zaorsky, T M Churilla, B L Egleston, S G Fisher, J A Ridge, E M Horwitz, Je Meyer Md
BACKGROUND: The purpose of our study was to characterize the causes of death among cancer patients as a function of objectives: (I) calendar year, (II) patient age, and (III) time after diagnosis. PATIENTS AND METHODS: US death certificate data in SEER Stat 8.2.1 were used to categorize cancer patient death as being due to index-cancer, non-index-cancer, and non-cancer cause from 1973 to 2012. In addition, data were characterized with standardized mortality ratios (SMRs), which provide the relative risk of death compared to all persons...
November 9, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27828241/enhanced-linear-absorption-coefficient-of-in-plane-monolayer-graphene-on-a-silicon-microring-resonator
#17
Heng Cai, Yahui Cheng, He Zhang, Qingzhong Huang, Jinsong Xia, Regis Barille, Yi Wang
We demonstrate that enhanced linear absorption coefficient (LAC) of in-plane monolayer graphene is determined by the optical transmission spectra of a graphene layer coated symmetrically coupled add-drop silicon microring resonator (SC-ADSMR), of which the value is around 0.23 dB/µm. In contrast to the traditional cut-back method, the measured results aren't dependent on the coupling efficiency between the fiber tip and the waveguide. Moreover, precisely evaluation of graphene layer coated silicon microring resonator (SMR) is crucial for future optoelectronic devices with compact footprint and low power consumption...
October 17, 2016: Optics Express
https://www.readbyqxmd.com/read/27821675/lung-cancer-mortality-among-vermont-granite-workers-factors-influencing-exposure-response-evaluation
#18
Pamela M Vacek, Peter W Callas
OBJECTIVE: To understand why 2 studies relating crystalline silica exposure to lung-cancer mortality in Vermont granite workers yielded conflicting results. METHODS: Data used in the 2 studies were linked to identify discrepancies. Mortality data and employment histories from the earlier study were revised based on data obtained in the later study. SMR were computed and Poisson regressions corresponding to those in the earlier study were performed using the original and revised data...
November 7, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27817141/mortality-in-adults-with-hypopituitarism-a-systematic-review-and-meta-analysis
#19
Sina Jasim, Fares Alahdab, Ahmed T Ahmed, Shrikant Tamhane, Larry J Prokop, Todd B Nippoldt, M Hassan Murad
PURPOSE: Hypopituitarism is a rare disorder with significant morbidity. To study the evidence on the association of premature mortality and hypopituitarism. METHODS: A comprehensive search of multiple databases: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus was conducted through August, 2015. Eligible studies that evaluated patients with hypopituitarism and reported mortality estimates were selected following a predefined protocol...
November 5, 2016: Endocrine
https://www.readbyqxmd.com/read/27814719/occupational-exposure-to-silica-dust-and-risk-of-lung-cancer-an-updated-meta-analysis-of-epidemiological-studies
#20
Satiavani Poinen-Rughooputh, Mahesh Shumsher Rughooputh, Yanjun Guo, Yi Rong, Weihong Chen
BACKGROUND: Crystalline silica is considered as one of the most common and serious occupational hazards to workers' health. Although its association with lung cancer has been studied for many decades, the conclusion remains somewhat controversial. Our objectives are to review and summarize the epidemiological evidence on the relationship between occupational silica exposure and risk of lung cancer and to provide an update on this major occupational health concern. METHODS: Eligible studies up to 29 April 2016 were identified...
November 4, 2016: BMC Public Health
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