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https://www.readbyqxmd.com/read/28523584/external-validation-of-saps-3-and-mpm0-iii-scores-in-48-816-patients-from-72-brazilian-icus
#1
Giulliana Martines Moralez, Ligia Sarmet Cunha Farah Rabello, Thiago Costa Lisboa, Mariza da Fonte Andrade Lima, Rodrigo Marques Hatum, Fernando Vinicius Cesar De Marco, Alessandra Alves, Jorge Eduardo da Silva Soares Pinto, Hélia Beatriz Nunes de Araújo, Grazielle Viana Ramos, Aline Reis Silva, Guilherme Côrtes Fernandes, Guilherme Brenande Alves Faria, Ciro Leite Mendes, Roberto Álvaro Ramos Filho, Valdênia Pereira de Souza, Pedro Emmanuel Alvarenga Americano do Brasil, Fernando Augusto Bozza, Jorge Ibrain Figueira Salluh, Marcio Soares
BACKGROUND: The performance of severity-of-illness scores varies in different scenarios and must be validated prior of being used in a specific settings and geographic regions. Moreover, models' calibration may deteriorate overtime and performance of such instruments should be reassessed regularly. Therefore, we aimed at to validate the SAPS 3 in a large contemporary cohort of patients admitted to Brazilian ICUs. In addition, we also compared the performance of the SAPS 3 with the MPM0-III...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28514928/challenges-in-evaluation-of-screening-for-gastric-cancer-among-men-based-on-nonrandomized-design
#2
Ilkka Vohlonen, Matti Härkönen, Nea Malila, Eero Pukkala, Pentti Sipponen, Veli Koistinen, Matti Hakama
BACKGROUND: Objective was to quantify biases in screening for gastric cancer when comparing attenders to nonattenders using serum pepsinogen I (SPGI) level as primary test. METHODS: In mid 1990s, all men aged 51-65 years from two Finnish cities were invited to SPGI screening. Mortality and premature mortality in attenders were compared to nonattenders. Efficacy of screening was studied by 15 years' follow-up of standardized mortality ratio (SMR) and potential years of life lost (PYLL) due to gastric cancer...
July 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28509760/global-longitudinal-strain-predicts-outcome-after-mitraclip-implantation-for-secondary-mitral-regurgitation
#3
Rodolfo Citro, Cesare Baldi, Patrizio Lancellotti, Angelo Silverio, Gennaro Provenza, Michele Bellino, Michele R Di Muro, Generoso Mastrogiovanni, Roberta De Rosa, Gennaro Galasso, Eduardo Bossone, Pietro Giudice, Federico Piscione
AIM: The aim of this study was to assess preoperative determinants, prevalence, and prognostic impact of left ventricular (LV) reverse remodeling (LVRR) in patients with secondary mitral regurgitation (SMR), undergoing MitraClip implantation (MCi). METHODS: From March 2012 to January 2015, a total of 41 consecutive patients with moderate-to-severe SMR treated successfully with MCi were enrolled. All patients underwent clinical and echocardiographic follow-up after MCi...
May 13, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28508614/methods-for-rating-sexual-development-in-girls
#4
Vincenzo De Sanctis, Ihab Zaki Elhakim, Ashraf T Soliman, Heba Elsedfy, Rania Elalaily, Giuseppe Millimaggi
Sexual maturity rating (SMR) is important in population studies and in clinical care. Pubertal staging allows doctors to assess the maturation of adolescents to correlate several pubertal phenomena such as age at menarche, growth spurt and final height, to advise and manage patients appropriately and to have sensitive "sensors" of the effects of environmental exposure on human populations. The commonly used markers of the timing of female puberty are thelarche and menarche. Appearance of the breast bud is the first indicator of puberty onset in 90% of girls...
September 2016: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28501121/validation-of-a-field-spinal-motion-restriction-protocol-in-a-level-i-trauma-center
#5
James M Tatum, Nicolas Melo, Ara Ko, Navpreet K Dhillon, Eric J T Smith, Dorothy A Yim, Galinos Barmparas, Eric J Ley
BACKGROUND: Spinal motion restriction (SMR) after traumatic injury has been a mainstay of prehospital trauma care for more than 3 decades. Recent guidelines recommend a selective approach with cervical spine clearance in the field when criteria are met. MATERIALS AND METHODS: In January 2014, the Department of Health Services of the City of Los Angeles, California, implemented revised guidelines for cervical SMR after blunt mechanism trauma. Adult patients (aged ≥18 y) with an initial Glasgow Coma Scale (GCS) score of ≥13 presented to a single level I trauma center after blunt mechanism trauma over the following 1-y period were retrospectively reviewed...
May 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28499197/biomolecular-stiffness-detection-based-on-positive-frequency-shift-of-cmos-compatible-gigahertz-solidly-mounted-resonators
#6
Qingrui Yang, Shuting Pan, Yuan Zhao, Hao Zhang, Wei Pang, Xuexin Duan
In this work, gigahertz solidly mounted resonators (SMRs) (2.5GHz) were designed and fabricated to construct a novel particle-resonator system to achieve the biomolecular stiffness sensing in real time. The positive frequency shift of the system was used to estimate the stiffness of biomolecules connecting between the SMR and attached particles. The working principle was revealed by the mathematical analysis of the general block-spring model of the system. Further interpretations about the mechanism of such elastic interaction from the perspective of acoustic resonant modes of SMRs were given by finite element method...
May 4, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28490663/quantitative-estimated-exposure-to-vinyl-chloride-and-risk-of-angiosarcoma-of-the-liver-and-hepatocellular-cancer-in-the-us-industry-wide-vinyl-chloride-cohort-mortality-update-through-2013
#7
Kenneth A Mundt, Linda D Dell, Lori Crawford, Alexa E Gallagher
OBJECTIVE: To evaluate mortality risks of angiosarcoma of the liver (ASL), primary hepatocellular carcinoma (HCC) and other cancers among 9951 men employed between 1942 and 1972 at 35 US vinyl chloride (VC) or polyvinyl chloride plants followed for mortality through 31 December 2013. METHODS: SMR and time-dependent Cox proportional hazards analyses were used to evaluate mortality risks by cumulative VC exposure. RESULTS: Liver cancer mortality was elevated (SMR=2...
May 10, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28489201/water-temperature-body-mass-and-fasting-heat-production-of-pacu-piaractus-mesopotamicus
#8
Fredy A A Aguilar, Thaline M P DA Cruz, Gerson B Mourão, José Eurico P Cyrino
Knowledge on fasting heat production (HEf) of fish is key to develop bioenergetics models thus improving feeding management of farmed species. The core of knowledge on HEf of farmed, neotropical fish is scarce. This study assessed the effect of body mass and water temperature on standard metabolism and fasting heat production of pacu, Piaractus mesopotamicus, an omnivore, Neotropical fresh water characin important for farming and fisheries industries all through South American continent. An automated, intermittent flow respirometry system was used to measure standard metabolic rate (SMR) of pacu (17 - 1,050 g) at five water temperatures: 19, 23, 26, 29 and 33 °C...
April 27, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28471838/risk-of-colorectal-cancer-and-associated-mortality-in-hiv-a-systematic-review-and-meta-analysis
#9
Tyler J O'Neill, Joseph Djiometio Nguemo, Anne-Marie Tynan, Ann N Burchell, Tony Antoniou
BACKGROUND: As people with HIV live longer, the numbers of colorectal cancer cases are expected to increase. We sought to compare colorectal cancer incidence and cause-specific mortality among people living with and without HIV. DESIGN: Systematic review and meta-analysis. METHODS: We searched five electronic databases to 28 June 2016 for primary studies reporting standardized incidence ratios (SIR), standardized mortality ratios (SMR)/hazard ratios or data sufficient for estimating these summary measures...
May 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28468793/mortality-in-anca-associated-vasculitis-a-meta-analysis-of-observational-studies
#10
Ju Ann Tan, Natasha Dehghan, Wenjia Chen, Hui Xie, John M Esdaile, J Antonio Avina-Zubieta
OBJECTIVE: To determine the magnitude of all-cause mortality risk in patients with antineutrophil cytoplasmic antibodies-associated vasculitis (AAV) compared with the general population through a meta-analysis of observational studies. METHODS: We searched Medline and Embase databases from their inception to April 2015. Observational studies that met the following criteria were assessed by two researchers: (1) clearly defined AAV identified by either the American College of Rheumatology 1990 classification criteria or the 2012 Chapel Hill Consensus Conference disease definitions, and (2) reported standardised mortality ratios (SMR) and 95% CI...
May 3, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28464214/cancer-specific-mortality-cure-fraction-and-noncancer-causes-of-death-among-diffuse-large-b-cell-lymphoma-patients-in-the-immunochemotherapy-era
#11
Nadia Howlader, Angela B Mariotto, Caroline Besson, Gita Suneja, Kim Robien, Naji Younes, Eric A Engels
BACKGROUND: Survival after the diagnosis of diffuse large B-cell lymphoma (DLBCL) has been increasing since 2002 because of improved therapies; however, long-term outcomes for these patients in the modern treatment era are still unknown. METHODS: Using Surveillance, Epidemiology, and End Results data, this study first assessed factors associated with DLBCL-specific mortality during 2002-2012. An epidemiologic risk profile, based on clinical and demographic characteristics, was used to stratify DLBCL cases into low-, medium-, and high-risk groups...
May 2, 2017: Cancer
https://www.readbyqxmd.com/read/28463667/culture-independent-detection-of-chlorhexidine-resistance-genes-qaca-b-and-smr-in-bacterial-dna-recovered-from-body-sites-treated-with-chlorhexidine-containing-dressings
#12
Md Abu Choudhury, Hanna E Sidjabat, Irani U Rathnayake, Nicole Gavin, Raymond J Chan, Nicole Marsh, Shahera Banu, Flavia Huygens, David L Paterson, Claire M Rickard, David J McMillan
PURPOSE: Dressings containing chlorhexidine gluconate (CHG) are increasingly used in clinical environments for prevention of infection at central venous catheter insertion sites. Increased tolerance to this biocide in staphylococci is primarily associated with the presence of qacA/B and smr genes. METHODOLOGY: We used a culture-independent method to assess the prevalence of these genes in 78 DNA specimens recovered from the skin of 43 patients at catheter insertion sites in the arm that were covered with CHG dressings...
April 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28443526/transformation-of-excess-mortality-in-people-with-schizophrenia-and-bipolar-disorder-in-taiwan
#13
Y-J Pan, L-L Yeh, H-Y Chan, C-K Chang
BACKGROUND: Given the concerns regarding the adverse health outcomes associated with weight gain and metabolic syndrome in relation to use of second-generation antipsychotics (SGAs), we aimed in this study to explore whether the increase in the use of SGAs would have any impacts on the trend of excess mortality in people with schizophrenia and bipolar disorder (BPD). METHOD: Two nationwide samples of individuals with schizophrenia and BPD were identified in Taiwan's National Health Insurance Research Database in 2003 and in 2008, respectively...
April 26, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28440974/risk-estimation-for-lung-cancer-in-libya-analysis-based-on-standardized-morbidity-ratio-poisson-gamma-model-bym-model-and-mixture-model
#14
Maryam Ahmed Alhdiri, Nor Azah Samat, Zulkifley Mohamed
Cancer is the most rapidly spreading disease in the world, especially in developing countries, including Libya. Cancer represents a significant burden on patients, families, and their societies. This disease can be controlled if detected early. Therefore, disease mapping has recently become an important method in the fields of public health research and disease epidemiology. The correct choice of statistical model is a very important step to producing a good map of a disease. Libya was selected to perform this work and to examine its geographical variation in the incidence of lung cancer...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28439641/data-driven-metabolic-subtypes-predict-future-adverse-events-in-individuals-with-type-1-diabetes
#15
Raija Lithovius, Iiro Toppila, Valma Harjutsalo, Carol Forsblom, Per-Henrik Groop, Ville-Petteri Mäkinen
AIMS/HYPOTHESIS: Previously, we proposed that data-driven metabolic subtypes predict mortality in type 1 diabetes. Here, we analysed new clinical endpoints and revisited the subtypes after 7 years of additional follow-up. METHODS: Finnish individuals with type 1 diabetes (2059 men and 1924 women, insulin treatment before 35 years of age) were recruited by the national multicentre FinnDiane Study Group. The participants were assigned one of six metabolic subtypes according to a previously published self-organising map from 2008...
April 24, 2017: Diabetologia
https://www.readbyqxmd.com/read/28438928/the-impact-of-healthcare-exposure-on-genotypic-antiseptic-tolerance-among-pediatric-staphylococcus-aureus-infections
#16
J Chase McNeil, Kristina G Hultén, Edward O Mason, Sheldon L Kaplan
Background: Staphylococcus aureus possessing either the smr or qacA/B genes are associated with decreased susceptibility to chlorhexidine gluconate (CHG) and other antiseptics. Previous studies of antiseptic tolerant staphylococci have largely focused on high-risk populations and the exact role of healthcare exposure on acquisition of these organisms is unclear. We sought to describe the risk factors and features of infection caused by antiseptic tolerant S. aureus in a general pediatric population.Methods: Isolates were selected from an ongoing S...
April 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28438787/mortality-from-cancer-and-other-causes-among-italian-chrysotile-asbestos-miners
#17
Enrico Pira, Canzio Romano, Francesca Donato, Claudio Pelucchi, Carlo La Vecchia, Paolo Boffetta
OBJECTIVE: To investigate the long-term mortality of a cohort of Italian asbestos miners. METHODS: The cohort included 1056 men employed in a chrysotile mine between 1930 and 1990, who were followed up during 1946-2014, for a total of 37 471 person-years of observation. Expected deaths and SMRs were computed using national and local (after 1980, when available) reference. RESULTS: A total of 294 (27.8%) subjects were alive and at the end of follow-up, 722 (68...
April 24, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28436050/comparing-performance-of-surgeons-using-risk-adjusted-procedures
#18
Xu Tang, Fah F Gan
It is naive and incorrect to use the proportions of successful operations to compare the performance of surgeons because the patients' risk profiles are different. In this paper, we explore the use of risk-adjusted procedures to compare the performance of surgeons. One such risk-adjusted statistic is the standardized mortality ratio (SMR), which measures the performance of a surgeon adjusted for the risks of patients assuming the average performance of a group of surgeons. Unlike the traditional SMR which is defined based on a population, this SMR is a random variable...
April 24, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28430884/a-20-year-temporal-change-analysis-in-incidence-presenting-phenotype-and-mortality-in-the-dutch-ibdsl-cohort-can-diagnostic-factors-explain-the-increase-in-ibd-incidence
#19
Tim R A van den Heuvel, Steven F G Jeuring, Maurice P Zeegers, Dorien H E van Dongen, Anouk Wolters, Ad A M Masclee, Wim H Hameeteman, Marielle J L Romberg-Camps, Liekele E Oostenbrug, Marieke J Pierik, Daisy M Jonkers
Background: The aim was to study temporal changes in incidence, disease phenotype at diagnosis, and mortality of adult inflammatory bowel disease (IBD) patients in South Limburg, the Netherlands, diagnosed between 1991 and 2010. In addition, the 2010 IBD prevalence was estimated. Methods: A multi-faceted approach including hospital administrations, the national pathology registry, and general practitioners led to the identification of 1162 patients with Crohn's disease (CD), 1663 with ulcerative colitis (UC) and 84 with unclassified IBD (IBD-U)...
April 20, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28430518/tunable-sign-change-of-spin-hall-magnetoresistance-in-pt-nio-yig-structures
#20
Dazhi Hou, Zhiyong Qiu, Joseph Barker, Koji Sato, Kei Yamamoto, Saül Vélez, Juan M Gomez-Perez, Luis E Hueso, Fèlix Casanova, Eiji Saitoh
Spin Hall magnetoresistance (SMR) has been investigated in Pt/NiO/YIG structures in a wide range of temperature and NiO thickness. The SMR shows a negative sign below a temperature that increases with the NiO thickness. This is contrary to a conventional SMR theory picture applied to the Pt/YIG bilayer, which always predicts a positive SMR. The negative SMR is found to persist even when NiO blocks the spin transmission between Pt and YIG, indicating it is governed by the spin current response of the NiO layer...
April 7, 2017: Physical Review Letters
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