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https://www.readbyqxmd.com/read/29779295/neck-pain-what-if-it-is-not-musculoskeletal
#1
Nirosen Vijiaratnam, David R Williams, Kelly L Bertram
BACKGROUND: Neck pain is a common presentation in general practice, with muscle strain or osteoarthritis the most common diagnoses. A systematic approach for identifying red flags for alternative causes is required to appropriately investigate or refer for specialist opinion. OBJECTIVE: The aim of this article is to highlight features of neurological and other causes of neck pain in adults that may present in general practice, and to outline a quick and practical diagnostic approach...
May 2018: Australian journal of general practice
https://www.readbyqxmd.com/read/29779281/-effects-of-tumor-necrosis-factor-%C3%AE-on-osteogenic-differentiation-and-notch-signaling-pathway-in-human-periodontal-ligament-stem-cells
#2
Yu Ma, Shu-Hui Li, Xin-Xin Ding, Pei-Ling Wu
OBJECTIVE: To evaluate the effects of tumor necrosis factor-α (TNF-α) on osteogenic differentiation and Notch signaling pathway of periodontal ligament stem cells (PDLSCs) and to investigate the regulatory role of Notch signaling pathway on the osteogenic differentiation of PDLSCs under the influence of TNF-α. METHODS: PDLSCs were obtained through enzyme digestion and tissue block method. The expression levels of stem cell surface markers CD105, CD90, CD146, CD45, and CD31 were detected by fluorescence activated cell sorter (FACS)...
April 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29779273/-effects-of-inhibitory-concentration-minocycline-on-the-proliferation-differentiation-and-mineralization-of-osteoblasts
#3
Hua-Ying Shao, Yi-Gong Zhang, Xue Yang, Qiong-Yue Zhang, Xiao-Hong Wu
OBJECTIVE: To study the effect of the inhibitory concentration minocycline on the proliferation, differentiation, and expression of Runt-related transcription factor 2 (Runx2), alkaline phosphatase (ALP) and osteopontin (OPN) mRNA of osteoblasts. METHODS: Primary osteoblasts were cultured in osteogenic induction medium containing 0, 0.1, 0.5, 1, 10 μg·mL⁻¹ minocycline. Cell counting kit-8 was used to observe cell proliferation. ALP activity assay, alizarin red S staining, and real-time quantitative polymerase chain reaction (PCR) were used to determine cell differentiation and mineralization...
April 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29779261/better-diet-quality-is-associated-with-lower-odds-of-severe-periodontitis-in-us-hispanics-latinos
#4
Christian R Salazar, Nadia Laniado, Yasmin Mossavar-Rahmani, Luisa N Borrell, Qibin Qi, Daniela Sotres-Alvarez, Douglas E Morse, Richard H Singer, Robert C Kaplan, Victor Badner, Ira B Lamster
AIM: We investigated the cross-sectional association between diet quality and severe periodontitis in a sample of diverse Hispanics from the Hispanic Community Health Study/Study of Latinos. MATERIALS AND METHODS: A total of 13,920 Hispanic/Latinos aged 18-74 years of different heritages underwent a full-mouth oral examination and completed two 24hr dietary recalls during 2008-2011. Severe periodontitis was defined as having ≥30% tooth sites with clinical attachment loss ≥ 5mm...
May 19, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29779132/cryptic-dispersal-of-cyanidiophytina-rhodophyta-in-non-acidic-environments-from-turkey
#5
Manuela Iovinella, Ayla Eren, Gabriele Pinto, Antonino Pollio, Seth J Davis, Paola Cennamo, Claudia Ciniglia
Cyanidiophytina are a group of polyextremophilic red algae with a worldwide, but discontinuous colonization. They are restricted to widely dispersed hot springs, geothermal habitats, and also some human-altered environments. Cyanidiophytina are predominant where pH is prohibitive for the majority of eukaryotes (pH 0.5-3). Turkey is characterized by areas rich in volcanic activity separated by non-volcanic areas. Here we show that Cyanidiophycean populations are present in thermal baths located around Turkey on neutral/alkaline soils...
May 19, 2018: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/29779121/a-comprehensive-comparable-study-of-the-physiological-properties-of-four-microalgal-species-under-different-light-wavelength-conditions
#6
Yu Zhong, Peng Jin, Jay J Cheng
Microalgae treated with blue light have potential for production of human nutrition supplement and biofuel due to their higher biomass productivity and favorable fatty acid composition. Chlorella vulgaris, Chlorella pyrenoidosa, Scenedesmus quadricauda and Scenedesmus obliquus are representative green microalgae which are widely reported for algal production. In this study, we provide a systematic investigation of the biomass productivity, photosynthetic pigments, chlorophyll fluorescence and fatty acid content of the four green microalgae...
May 19, 2018: Planta
https://www.readbyqxmd.com/read/29779011/fifteen-minute-consultation-red-flags-for-metabolic-disease-in-routine-bloods
#7
Caroline Hart, James E Davison, Maureen A Cleary
No abstract text is available yet for this article.
May 19, 2018: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/29778960/rapid-colorimetric-detection-of-p53-protein-function-using-dna-gold-nanoconjugates-with-applications-for-drug-discovery-and-cancer-diagnostics
#8
Enock Assah, Walter Goh, Xin Ting Zheng, Ting Xiang Lim, Jun Li, David Lane, Farid Ghadessy, Yen Nee Tan
The tumor suppressor protein p53 plays a central role in preventing cancer through interaction with DNA response elements (REs) to regulate target gene expression in cells. Due to its significance in cancer biology, relentless efforts have been directed toward understanding p53-DNA interactions for the development of cancer therapeutics and diagnostics. In this paper, we report a rapid, label-free and versatile colorimetric assay to detect wildtype p53 DNA-binding function in complex solutions. The assay design is based on a concept that alters interparticle-distances between RE-AuNPs from a crosslinking effect induced through tetramerization of wildtype p53 protein (p53-WT) upon binding to canonical DNA motifs modified on gold nanoparticles (RE-AuNPs)...
May 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29778891/leukocytes-and-drug-resistant-cancer-cells-are-targets-for-intracellular-delivery-by-adenoviral-dodecahedron
#9
Marta Jedynak, David Laurin, Patryk Dolega, Malgorzata Podsiadla-Bialoskorska, Inga Szurgot, Jadwiga Chroboczek, Ewa Szolajska
One of the major factors limiting the effectiveness of cancer chemotherapy is inefficient drug delivery. Systems enabling efficient delivery and enhanced intracellular uptake, appear particularly promising in this respect. Virus-like particle, adenoviral dodecahedron (Dd), employs receptor-mediated endocytosis for cell penetration and is able to deliver intracellularly dozens of cargo molecules attached to one particle. We focused on studying Dd properties in the context of cancer treatment, showing that intratumoral injection of Dd, assessed in mouse xenograft model, results in vector accumulation in tumor without spreading in off-target organs...
May 17, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29778718/nimbolide-epigenetically-regulates-autophagy-and-apoptosis-in-breast-cancer
#10
Venkatesh Pooladanda, Soumya Bandi, Sandhya Rani Mondi, Krishna Mohan Gottumukkala, Chandraiah Godugu
Autophagy is a critical regulator of cellular homeostasis and its dysregulation often results in various disease manifestations, including cancer. Nimbolide, an active chemical constituent of neem (Azadirachta indica) exhibits potent anticancer effects. Although, nimbolide mediated apoptosis activation in breast cancer cells is well known. Nevertheless, its role in autophagy induction mechanism and epigenetic alteration is not explored previously. Our current study intended to bridge the gaps in the existing research by exploring the potential of nimbolide in inducing autophagy, which could counter regulate the transformations in breast cancer...
May 17, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29778713/concluding-commentary-on-current-trends-to-enhance-the-clinical-safety-of-pediatric-transfusion-focusing-on-prevention-of-untoward-complications-of-hsc-transplantation-newer-strategies-for-improving-the-standards-of-safety-quality-of-stem-cells-expansion-for
#11
REVIEW
Irena Sniecinski, Jerard Seghatchian
Clinical practice and related diagnostic, development and research [DDR] strategies in pediatric transfusion and transplantation cover a broad range of multidisciplinary studies, performed by many professionals involved in this most challenging clinical field [1]. This commentary on the current position and future perspectives in pediatric transfusion field is aimed to highlight major unresolved transfusion complications in pediatric patients, namely red blood cell and platelet alloimmunisation, and new ones such as nosocomial infection, thrombosis and multi-organ failure...
May 16, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29778645/screening-and-selection-of-artificial-riboswitches
#12
Svetlana V Harbaugh, Jennifer Martin, Jenna Weinstein, Grant Ingram, Nancy Kelley-Loughnane
Synthetic riboswitches are engineered to regulate gene expression in response to a variety of non-endogenous small molecules, and a challenge to select this engineered response requires robust screening tools. A new synthetic riboswitch can be created by linking an in vitro-selected aptamer library with a randomized expression platform followed by in vivo selection and screening. In order to determine response to analyte, we developed a dual-color reporter comprising elements of the E. coli fimbriae phase variation system: recombinase FimE controlled by a synthetic riboswitch and an invertible DNA segment (fimS) containing a constitutively active promoter placed between two fluorescent protein genes...
May 17, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29778484/effect-of-grain-or-by-product-based-concentrate-fed-with-early-or-late-harvested-first-cut-grass-silage-on-dairy-cow-performance
#13
D Pang, T Yan, E Trevisi, S J Krizsan
This study compared the effects of a grain-based conventional concentrate (GC) and a concentrate based on agro-industrial by-products (BC), fed with grass silage harvested at early (ES) or late (LS) maturity stage, on dairy performance, CH4 and CO2 emissions, and metabolic status of dairy cows. Twenty lactating Nordic Red cows averaging 81 d in milk and 31.9 kg of milk/d pre-trial were assigned to a replicated 4 × 4 Latin square design. Dietary treatments were in a 2 × 2 factorial arrangement. The silages were harvested 2 wk apart from the same primary growth grass ley...
May 16, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29778483/effect-of-replacing-maize-silage-with-red-clover-silage-in-the-diet-on-milk-fatty-acid-composition-in-cows
#14
Franziska Schulz, Edwin Westreicher-Kristen, Joachim Molkentin, Karin Knappstein, Andreas Susenbeth
This study aimed to evaluate the effect of replacing maize silage plus soybean meal with red clover silage (RCS) plus wheat on the fatty acid (FA) profile in the milk fat of cows. Forty-four lactating German Holstein cows were used in a 4 × 4 Latin square design with 21-d periods composed of 13 d of adaptation to diets followed by an 8-d sampling phase. Experimental diets offered as total mixed ration consisted of a constant forage-to-concentrate ratio (75:25) with target proportions of RCS to maize silage of 15:60 (RCS15 ), 30:45 (RCS30 ), 45:30 (RCS45 ), and 60:15 (RCS60 ) on a dry matter basis...
May 16, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29778331/goal-directed-perfusion-to-reduce-acute-kidney-injury-a-randomized-trial
#15
Marco Ranucci, Ian Johnson, Timothy Willcox, Robert A Baker, Christa Boer, Andreas Baumann, George A Justison, Filip de Somer, Paul Exton, Seema Agarwal, Rachael Parke, Richard F Newland, Renard G Haumann, Dirk Buchwald, Nathaen Weitzel, Rajamiyer Venkateswaran, Valeria Pistuddi
OBJECTIVE: To determine whether a goal-directed perfusion (GDP) strategy aimed at maintaining oxygen delivery (DO2 ) at ≥280 mL·min-1 ·m-2 reduces the incidence of acute kidney injury (AKI). METHODS: This multicenter randomized trial enrolled a total of 350 patients undergoing cardiac surgery in 9 institutions. Patients were randomized to receive either GDP or conventional perfusion. A total of 326 patients completed the study and were analyzed. Patients in the treatment arm were treated with a GDP strategy during cardiopulmonary bypass (CPB) aimed to maintain DO2 at ≥280 mL·min-1 ·m-2 ...
April 18, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29778229/a-novel-portable-filtration-system-for-sampling-and-concentration-of-microorganisms-demonstration-on-marine-microalgae-with-subsequent-quantification-using-ic-nasba
#16
Christos-Moritz Loukas, Matthew C Mowlem, Maria-Nefeli Tsaloglou, Nicolas G Green
This paper presents a novel portable sample filtration/concentration system, designed for use on samples of microorganisms with very low cell concentrations and large volumes, such as water-borne parasites, pathogens associated with faecal matter, or toxic phytoplankton. The example application used for demonstration was the in-field collection and concentration of microalgae from seawater samples. This type of organism is responsible for Harmful Algal Blooms (HABs), an example of which is commonly referred to as "red tides", which are typically the result of rapid proliferation and high biomass accumulation of harmful microalgal species in the water column or at the sea surface...
May 2018: Harmful Algae
https://www.readbyqxmd.com/read/29778222/exploring-dinoflagellate-biology-with-high-throughput-proteomics
#17
REVIEW
David Morse, Sirius P K Tse, Samuel C L Lo
Dinoflagellates are notorious for their ability to form the harmful algal blooms known as "red tides," yet the mechanisms underlying bloom formation remain poorly understood. Despite recent advances in nucleic acid sequencing, which have generated transcriptomes from a wide range of species exposed to a variety of different conditions, measuring changes in RNA levels have not generally produced great insight into dinoflagellate cell biology or environmental physiology, nor do we have a thorough grasp on the molecular events underpinning bloom formation...
May 2018: Harmful Algae
https://www.readbyqxmd.com/read/29778084/carbon-composite-lignin-based-adsorbents-for-the-adsorption-of-dyes
#18
Xiaohong Wang, Chenglong Jiang, Bingxia Hou, Yingying Wang, Chen Hao, Jingbo Wu
Carbon composite lignin-based adsorbent were prepared through hydrothermal method with glucose as carbon source, calcium lignosulfonate and triethylene tetramine as raw materials, respectively. The optimum synthesis conditions were determined by investigating the addition of carbon and triethylene tetramine. The adsorbent was used for the adsorption of azo dyes Congo red and Eriochrome blue black R, and the five factors affecting the adsorption were discussed, including pH of dyes, initial concentration, adsorption time, adsorption temperature and adsorbent dosage...
May 10, 2018: Chemosphere
https://www.readbyqxmd.com/read/29778083/performance-of-single-pass-and-by-pass-multi-step-multi-soil-layering-systems-for-low-c-n-ratio-polluted-river-water-treatment
#19
Cai-Jie Wei, Wei-Zhong Wu
Two kinds of hybrid two-step multi-soil-layering (MSL) systems loaded with different filter medias (zeolite-ceramsite MSL-1 and ceramsite-red clay MSL-2) were set-up for the low-(C/N)-ratio polluted river water treatment. A long-term pollutant removal performance of these two kinds of MSL systems was evaluated for 214 days. By-pass was employed in MSL systems to evaluate its effect on nitrogen removal enhancement. Zeolite-ceramsite single-pass MSL-1 system owns outstanding ammonia removal capability (24 g NH4 + -Nm-2 d-1 ), 3 times higher than MSL-2 without zeolite under low aeration rate condition (0...
May 7, 2018: Chemosphere
https://www.readbyqxmd.com/read/29777963/red-wolf-canis-rufus-sperm-quality-and-quantity-is-affected-by-semen-collection-method-extender-components-and-post-thaw-holding-temperature
#20
Ashley D Franklin, William T Waddell, Karen L Goodrowe
Cryopreserving genetic resources is becoming increasingly important for species management. In the zoo-based red wolf (Canis rufus) population, inbreeding continues to increase in the absence of new founders. Through banking sperm, we preserve genetic diversity and create the ability to decrease inbreeding accumulation in the future. The quality and quantity of banked sperm can be affected by cryopreservation media and semen collection methods. This study's objectives were to further optimize semen extender used for red wolf sperm cryopreservation, investigate effects of post-thaw holding temperature, and to determine if urethral catheterization is an effective method for semen collection in this species...
May 16, 2018: Theriogenology
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