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https://www.readbyqxmd.com/read/28743127/a-rare-presentation-of-immunoglobulin-a-nephropathy-acute-kidney-injury
#1
Meric Oruc, Haydar Durak, Serkan Feyyaz Yalin, Nurhan Seyahi, Mehmet Rıza Altıparmak, Sinan Trabulus
BACKGROUND: Acute kidney injury (AKI) is known as an uncommon presentation in immunoglobulin A nephropathy (IgAN). The aim of our study was to analyze the clinical data and biopsy findings in IgAN patients presenting with AKI. METHODS: We performed a retrospective analysis of all subjects who had biopsy-proven IgAN and presented with AKI during June 2002 September 2015. The following data were obtained from medical records. RESULTS: A total of 15 patients of 123 patients (12...
July 26, 2017: Nephron
https://www.readbyqxmd.com/read/28742956/fluorescence-and-sensing-applications-of-graphene-oxide-and-graphene-quantum-dots-a-review
#2
Peng Zheng, Nianqiang Wu
Graphene oxide and graphene quantum dots are attractive fluorophores, which are inexpensive, non-toxic, photo-stable, water-soluble, biocompatible and environmentally friendly. They find extensive applications in fluorescent biosensors and chemi-sensors, in which they either serve as fluorophores or quenchers. As fluorophores, they display the tunable photoluminescence emission and the "Giant Red-Edge Effect". As quenchers, they exhibit a remarkable quenching efficiency via either electron transfer or Förster resonance energy transfer (FRET) process...
July 25, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28742881/epiphytes-in-wooded-pastures-isolation-matters-for-lichen-but-not-for-bryophyte-species-richness
#3
Thomas Kiebacher, Christine Keller, Christoph Scheidegger, Ariel Bergamini
Sylvo-pastoral systems are species-rich man-made landscapes that are currently often severely threatened by abandonment or management intensification. At low tree densities, single trees in these systems represent habitat islands for epiphytic cryptogams. Here, we focused on sycamore maple (Acer pseudoplatanus) wooded pastures in the northern European Alps. We assessed per tree species richness of bryophytes and lichens on 90 sycamore maple trees distributed across six study sites. We analysed the effects of a range of explanatory variables (tree characteristics, environmental variables and isolation measures) on the richness of epiphytic bryophytes and lichens and various functional subgroups (based on diaspore size, habitat preference and red list status)...
2017: PloS One
https://www.readbyqxmd.com/read/28742830/regulatory-effects-of-zinc-on-cadmium-induced-cytotoxicity-in-chronic-inflammation
#4
Paola Bonaventura, Aline Lamboux, Francis Albarède, Pierre Miossec
OBJECTIVES: Zinc (Zn) has major effects on immune system activation while Cadmium (Cd) has anti-inflammatory and anti-proliferative effects in several chronic inflammatory contexts. The aim of this work was to investigate by which mechanisms Zn could compete with Cd and eventually counteract its deleterious effects. Rheumatoid arthritis (RA) synoviocytes exposed to cytokines were used as a model of chronic inflammation; osteoarthritis (OA) synoviocytes were used as control. METHODS: Cell/medium fractionation constants were analyzed for different metals by inductively-coupled-plasma mass-spectrometry by comparison to the 70Zn spike...
2017: PloS One
https://www.readbyqxmd.com/read/28742673/practice-bulletin-no-181-prevention-of-rh-d-alloimmunization
#5
(no author information available yet)
Advances in the prevention and treatment of Rh D alloimmunization have been one of the great success stories of modern obstetrics. There is wide variation in prevalence rates of Rh D-negative individuals between regions, for example from 5% in India to 15% in North America (1). However, high birth rates in low prevalence areas means Rh hemolytic disease of the newborn is still an important cause of morbidity and mortality in countries without prophylaxis programs (1). In such countries, 14% of affected fetuses are stillborn and one half of live born infants suffer neonatal death or brain injury (1)...
August 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28742667/practice-bulletin-no-181-summary-prevention-of-rh-d-alloimmunization
#6
(no author information available yet)
Advances in the prevention and treatment of Rh D alloimmunization have been one of the great success stories of modern obstetrics. There is wide variation in prevalence rates of Rh D-negative individuals between regions, for example from 5% in India to 15% in North America (1). However, high birth rates in low prevalence areas means Rh hemolytic disease of the newborn is still an important cause of morbidity and mortality in countries without prophylaxis programs (1). In such countries, 14% of affected fetuses are stillborn and one half of live born infants suffer neonatal death or brain injury (1)...
August 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28742384/antiproliferative-effects-of-red-and-white-wine-extracts-in-pc-3-prostate-cancer-cells
#7
Roxane Tenta, Elizabeth Fragopoulou, Magafoula Tsoukala, Marianna Xanthopoulou, Maria Skyrianou, Harris Pratsinis, Dimitris Kletsas
Experimental and epidemiological studies have shown that antioxidant polyphenols can act as chemopreventive agents against prostate cancer. Cabernet Sauvignon and Rombola wine were extracted in order to obtain fractions containing different classes of compounds. All extracts inhibited the androgen-insensitive human prostate cancer cells (PC-3) proliferation in a dose-dependent manner. The most potent compounds were selected to be further tested.Treatment of PC-3 cells with the selected wine extracts marginally increased the cell distribution in S phase, while producing a remarkable induction of autophagy...
July 25, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28742328/attachable-pulse-sensors-integrated-with-inorganic-optoelectronic-devices-for-monitoring-heart-rates-at-various-body-locations
#8
Juho Kim, Namyun Kim, Minjeong Kwon, Jongho Lee
Monitoring cardiovascular signals such as heart rate and blood flow provides critically important healthcare information about patients under medical care. However, when the sensors are worn for extended times, the sensors sometimes require higher mechanical compatibility with soft deformable tissues. In this paper, we report an attachable and flexible pulse sensor (bending radius: 2.4 mm), integrated with micro-inorganic photodetectors (thickness: 4.1 μm, photocurrent: 8.99 μA under 1.5 mW/cm(2)) and a red light emitting diode (620 nm), to monitor vital signals for extended times...
July 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28742327/amphiphilic-peptide-nanorods-based-on-oligo-phenylalanine-as-a-biocompatible-drug-carrier
#9
Su Jeong Song, Seulgi Lee, Kyoung-Seok Ryu, Joon Sig Choi
Peptide nanostructure has been widely explored for drug delivery systems in recent studies. Peptides possess comparatively lower cytotoxicity and are more efficient than polymeric carriers. Here, we propose a peptide nanorod system, composed of an amphiphilic oligo-peptide RH3F8 (Arg-His3-Phe8) as a drug delivery carrier. Arginine is an essential amino acid in typical cell penetration peptides, and histidine induces endo/lysosomal escape because of its proton sponge effect. Phenylalanine is introduced to provide rich hydrophobicity for stable self-assembly and drug encapsulation...
July 25, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28742109/young-sprague-dawley-rats-infected-by-plasmodium-berghei-a-relevant-experimental-model-to-study-cerebral-malaria
#10
Sokhna Keita Alassane, Marie-Laure Nicolau-Travers, Sandie Menard, Olivier Andreoletti, Jean-Pierre Cambus, Noémie Gaudre, Myriam Wlodarczyk, Nicolas Blanchard, Antoine Berry, Sarah Abbes, David Colongo, Babacar Faye, Jean-Michel Augereau, Caroline Lacroux, Xavier Iriart, Françoise Benoit-Vical
Cerebral malaria (CM) is the most severe manifestation of human malaria yet is still poorly understood. Mouse models have been developed to address the subject. However, their relevance to mimic human pathogenesis is largely debated. Here we study an alternative cerebral malaria model with an experimental Plasmodium berghei Keyberg 173 (K173) infection in Sprague Dawley rats. As in Human, not all infected subjects showed cerebral malaria, with 45% of the rats exhibiting Experimental Cerebral Malaria (ECM) symptoms while the majority (55%) of the remaining rats developed severe anemia and hyperparasitemia (NoECM)...
2017: PloS One
https://www.readbyqxmd.com/read/28742069/nematode-grazing-promotes-bacterial-community-dynamics-in-soil-at-the-aggregate-level
#11
Yuji Jiang, Manqiang Liu, Jiabao Zhang, Yan Chen, Xiaoyun Chen, Lijun Chen, Huixin Li, Xue-Xian Zhang, Bo Sun
Nematode predation has important roles in determining bacterial community composition and dynamics, but the extent of the effects remains largely rudimentary, particularly in natural environment settings. Here, we investigated the complex microbial-microfaunal interactions in the rhizosphere of maize grown in red soils, which were derived from four long-term fertilization regimes. Root-free rhizosphere soil samples were separated into three aggregate fractions whereby the abundance and community composition were examined for nematode and total bacterial communities...
July 25, 2017: ISME Journal
https://www.readbyqxmd.com/read/28741955/synthesis-structures-and-photophysical-properties-of-a-series-of-rare-near-ir-emitting-copper-i-complexes
#12
Benjamin Hupp, Carl Schiller, Carsten Lenczyk, Marco Stanoppi, Katharina Edkins, Andreas Lorbach, Andreas Steffen
Herein, we report on the synthesis and structural characterization of a series of trigonal and tetrahedral cationic copper(I) complexes, bearing phosphine or N-heterocyclic carbene ligands as donors, with benzthiazol-2-pyridine (pybt) and benzthiazol-2-quinoline (qybt) acting as π-chromophores. The compounds are highly colored due to their (1)MLCT (MLCT = metal-to-ligand charge transfer) states absorbing between ca. λabs = 400-500 nm, with (1)ILCT (ILCT = intraligand charge transfer) states in the UV region...
July 25, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28741926/redesigned-spider-peptide-with-improved-antimicrobial-and-anticancer-properties
#13
Sonia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S Ravipati, Olivier Cheneval, Aurélie H Benfield, Alysha G Elliott, Angela Maria Kavanagh, Matthew A Cooper, Lai Yue Chan, Yen-Hua Huang, David J Craik
Gomesin, a disulfide-rich antimicrobial peptide produced by the Brazilian spider Acanthoscurria gomesiana, has been shown to be potent against Gram-negative bacteria and to possess selective anticancer properties against melanoma cells. In a recent study, a backbone cyclized analogue of gomesin was shown to be as active but more stable than its native form. In the current study, we were interested in improving the antimicrobial properties of the cyclic gomesin, understanding its selectivity towards melanoma cells and elucidating its antimicrobial and anticancer mode of action...
July 25, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28741656/biochemical-evaluation-of-storage-lesion-in-canine-packed-erythrocytes
#14
C R Wilson, M B Pashmakova, J A Heinz, M C Johnson, H M Minard, M A Bishop, J W Barr
OBJECTIVES: This study describes the biochemical changes - also known as the storage lesion - that occur in canine packed red blood cells during ex vivo storage. MATERIALS AND METHODS: Ten 125-mL units of non-leuco-reduced packed red blood cells in citrate phosphate dextrose adenine were obtained from a commercial blood bank within 24 hours of donation. Samples were aseptically collected on days 1, 4, 7, 14, 28, 35 and 42 for measurement of sodium, potassium, chloride, lactate, glucose, pH and ammonia concentrations...
July 25, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28741596/the-response-of-mri-contrast-parameters-in-i-in-vitro-i-tissues-and-tissue-mimicking-phantoms-to-fractionation-by-histotripsy
#15
Steven Paul Allen, Eli Vlaisavljevich, Jiaqi Shi, Luis Hernandez-Garcia, Charles A Cain, Zhen Xu, Timothy L Hall
Histotripsy is a non-invasive, focused ultrasound lesioning technique that can ablate precise volumes of soft tissue using a novel mechanical fractionation mechanism. Previous research suggests that magnetic resonance imaging (MRI) may be a sensitive image-based feedback mechanism for histotripsy. However, there are insufficient data to form some unified understanding of the response of the MR contrast mechanisms in tissues to histotripsy. In this paper, we investigate the response of the MR contrast parameters R1, R2, and the apparent diffusion coefficient (ADC) to various treatment levels of histotripsy in in-vitro porcine liver, kidney, muscle, and blood clot as well in formulations of bovine red blood cells suspended in agar gel...
July 25, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28741383/adherence-to-mediterranean-diet-and-metabolic-syndrome-in-brca-mutation-carriers
#16
Eleonora Bruno, Siranoush Manoukian, Elisabetta Venturelli, Andreina Oliverio, Francesca Rovera, Giovanna Iula, Daniele Morelli, Bernard Peissel, Jacopo Azzolini, Eliana Roveda, Patrizia Pasanisi
BACKGROUND: Insulin resistance is associated with higher breast cancer (BC) penetrance in BRCA mutation carriers. Metabolic syndrome (MetS), an insulin resistance syndrome, can be reversed by adhering to the Mediterranean diet (MedDiet). In a dietary intervention trial on BRCA mutation carriers, we evaluated adherence to the MedDiet, and the association with the MetS, by analyzing data from the Mediterranean Diet Adherence Screener (MEDAS). METHODS: BRCA mutation carriers, with or without BC, aged 18 to 70 years, were eligible for the trial...
July 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28741250/effects-of-deoxynivalenol-don-and-its-microbial-biotransformation-product-deepoxy-deoxynivalenol-dom-1-on-a-trout-pig-mouse-and-human-cell-line
#17
Elisabeth Mayer, Barbara Novak, Alexandra Springler, Heidi E Schwartz-Zimmermann, Veronika Nagl, Nicole Reisinger, Sabine Hessenberger, Gerd Schatzmayr
Deoxynivalenol (DON), a trichothecene produced by various Fusarium species, is one of the most prevalent food- and feed-associated mycotoxins. The effects of DON and deepoxy-deoxynivalenol (DOM-1) were assessed in five different cell lines from different tissues and species starting from the first line of defense, the trout gill (RTgill-W1) and pig intestinal cells (IPEC-1 and IPEC-J2) over immune cells, as second line of defense (mouse macrophages RAW 264.7) to human liver cells (HepG2). Viability was assessed with a WST-1 assay, except for RTgill-W1, where a neutral red (NR) and sulforhodamine B (SRB) assay was performed...
July 24, 2017: Mycotoxin Research
https://www.readbyqxmd.com/read/28741204/remarks-on-the-current-quality-of-groundwater-in-vietnam
#18
EDITORIAL
Tran Le Luu
This paper reviews the current quality of groundwater in Vietnam. In Vietnam, groundwater is obtained primarily from tubewells, which have high concentrations of pollutants such as As, Fe, Mn, and NH4(+). In the areas where groundwater tests were conducted, arsenic levels ranged from 0.1-3050 μg/L, which substantially exceed the standard of 10 μg/L which has been established by the WHO. Contamination sources are distributed over a large area from the Red River Delta in the north to the Mekong River Delta in the south, putting as many as ten million people at risk of adverse health effects...
July 24, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28741030/hidden-and-overall-haemorrhage-following-minimally-invasive-and-open-transforaminal-lumbar-interbody-fusion
#19
Yang Yang, Liangming Zhang, Bin Liu, Mao Pang, Peigen Xie, Zihao Chen, Wenbin Wu, Feng Feng, Limin Rong
BACKGROUND: Hidden haemorrhage has been proved to be significant in joint surgery. However, when referring to lumbar interbody fusion, it is often ignored because of its invisibility. This randomized controlled study aimed to calculate and compare hidden haemorrhage following minimally invasive and open transforaminal lumbar interbody fusion (MIS-TLIF and open TLIF). Meanwhile, its clinical significance was also analyzed. MATERIALS AND METHODS: A total of 41 patients were included in this study, then they were randomized to receive MIS-TLIF or open TLIF, 21 and 20, respectively...
July 24, 2017: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/28740954/can-red-cell-distribution-width-be-used-as-a-predictor-of-acute-cholecystitis
#20
İlker Murat Arer, Hakan Yabanoğlu, Kenan Çalışkan
OBJECTIVE: Acute cholecystitis is a common disease requiring accurate markers for diagnosis and proper treatment. The aim of this study was to investigate the role of red cell distribution width (RDW) in acute cholecystitis. MATERIAL AND METHODS: 299 were included in the study. The subjects were divided into 2 groups; group 1 (n: 46) acute cholecystitis group and group 2 (n: 253) chronic cholecystitis group. The patients were compared with respect to demographic characteristics, white blood cell count, C-reactive protein, and red cell distribution width...
2017: Turk J Surg
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