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https://www.readbyqxmd.com/read/28521524/a-first-glance-into-the-nutritional-properties-of-the-sea-cucumber-parastichopus-regalis-from-the-mediterranean-sea-se-spain
#1
Christina C Roggatz, Mercedes González-Wangüemert, Hugo Pereira, Catarina Vizetto-Duarte, Maria João Rodrigues, Luísa Barreira, Manuela Moreira da Silva, João Varela, Luísa Custódio
This work reports for the first time the nutritional profile, including proximate chemical composition, amino acids, fatty acids and minerals of Parastichopus regalis from the Mediterranean Sea (SE Spain). The studied species had a high moisture content, moderate protein and low lipid levels. The most abundant amino acids were glutamic acid, arginine and tyrosine. Polyunsaturated fatty acids, especially arachidonic acid, dominated the fatty acid profile. Iron, sodium, calcium and zinc were the most abundant mine rals...
May 19, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28512032/cytotoxic-triterpene-diglycosides-from-the-sea-cucumber-stichopus-horrens
#2
Nguyen Xuan Cuong, Le Thi Vien, Le Hoang, Tran Thi Hong Hanh, Do Thi Thao, Nguyen Van Thanh, Nguyen Hoai Nam, Do Cong Thung, Phan Van Kiem, Chau Van Minh
Using various chromatographic separation techniques, eight triterpene diglycosides (1-8), including four new compounds namely stichorrenosides A-D (1-4), were isolated from a methanol extract of the Vietnamese sea cucumber S. horrens. Their structures were elucidated based on spectroscopic analyses, including HR ESI MS, 1D and 2D NMR. Their in vitro cytotoxic activity against five human cancer cell lines, Hep-G2 (hepatoma cancer), KB (epidermoid carcinoma), LNCaP (prostate cancer), MCF7 (breast cancer), and SK-Mel2 (melanoma), was evaluated using SRB methods...
May 6, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28490052/effects-of-endogenous-cysteine-proteinases-on-structures-of-collagen-fibres-from-dermis-of-sea-cucumber-stichopus-japonicus
#3
Yu-Xin Liu, Da-Yong Zhou, Dong-Dong Ma, Zi-Qiang Liu, Yan-Fei Liu, Liang Song, Xiu-Ping Dong, Dong-Mei Li, Bei-Wei Zhu, Kunihiko Konno, Fereidoon Shahidi
Autolysis of sea cucumber, caused by endogenous enzymes, leads to postharvest quality deterioration of sea cucumber. However, the effects of endogenous proteinases on structures of collagen fibres, the major biologically relevant substrates in the body wall of sea cucumber, are less clear. Collagen fibres were prepared from the dermis of sea cucumber (Stichopus japonicus), and the structural consequences of degradation of the collagen fibres caused by endogenous cysteine proteinases (ECP) from Stichopus japonicus were examined...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28481429/total-synthesis-of-echinoside-a-a-representative-triterpene-glycoside-of-sea-cucumbers
#4
Biao Yu, Xiaoping Chen, Xiaofei Shao, Wei Li, Xiaheng Zhang
Echinoside A, a sulphonylated holostane tetrasaccharide with potent anticancer and antifungal activities, is synthesized in a longest linear sequence of 35 steps and 0.6% overall yield; this represents the first synthesis of the characteristic triterpene glycosides which occur ubiquitously in sea cucumbers.
May 8, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28460346/cladolosides-i1-i2-j1-k1-k2-and-l1-monosulfated-triterpene-glycosides-with-new-carbohydrate-chains-from-the-sea-cucumber-cladolabes-schmeltzii
#5
Alexandra S Silchenko, Anatoly I Kalinovsky, Sergey A Avilov, Pelageya V Andryjaschenko, Pavel S Dmitrenok, Ekaterina A Chingizova, Igor Yu Dolmatov, Vladimir I Kalinin
Six new monosulfated triterpene glycosides, cladolosides I1 (1), I2 (2), J1 (3), K1 (4), K2 (5) and L1 (6) were isolated from the tropical Indo-West Pacific sea cucumber Cladolabes schmeltzii (Cladolabinae, Sclerodactylidae, Dendrochirotida). Structures of these glycosides were elucidated by 2D NMR spectroscopy and mass spectrometry. Four new types of carbohydrate chains have been found in 1-6. Cladolosides of the groups I and J are characterized by pentasaccharide carbohydrate chains sulfated at a terminal 3-O-methylglucose residue and branched by the position 4 of the first xylose residue, but differing from each other in the lengths of the main and side carbohydrate chains...
April 19, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28460072/exploring-the-structure-of-fucosylated-chondroitin-sulfate-through-bottom-up-nuclear-magnetic-resonance-and-electrospray-ionization-high-resolution-mass-spectrometry-approaches
#6
Gustavo Rc Santos, Ana Co Porto, Paulo Ag Soares, Eduardo Vilanova, Paulo As Mourão
Fucosylated chondroitin sulfate (FCS) from sea cucumbers is composed of a chondroitin sulfate (CS) central core and branches of sulfated fucose. The structure of this complex glycosaminoglycan is usually investigated via nuclear magnetic resonance (NMR) analyses of the intact molecule, ergo through a top-down approach, which often yield spectra with intricate sets of signals. Here we employed a bottom-up approach to analyze the FCSs from the sea cucumbers Isostichopus badionotus and Ludwigothurea grisea from their basic constituents, viz...
April 28, 2017: Glycobiology
https://www.readbyqxmd.com/read/28450116/a-characteristic-chondroitin-sulfate-trisaccharide-unit-with-a-sulfated-fucose-branch-exhibits-neurite-outgrowth-promoting-activity-novel-biological-roles-of-fucosylated-chondroitin-sulfates-isolated-from-the-sea-cucumber-apostichopus-japonicus
#7
Miharu Shida, Tadahisa Mikami, Jun-Ichi Tamura, Hiroshi Kitagawa
Chondroitin sulfate (CS) is a class of sulfated glycosaminoglycan (GAG) chains that consist of repeating disaccharide unit composed of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc). CS chains are found throughout the pericellular and extracellular spaces and contribute to the formation of functional microenvironments for numerous biological events. However, their structure-function relations remain to be fully characterized. Here, a fucosylated CS (FCS) was isolated from the body wall of the sea cucumber Apostichopus japonicus...
April 25, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28444138/the-evolution-of-neuropeptide-signalling-insights-from-echinoderms
#8
Dean C Semmens, Maurice R Elphick
Neuropeptides are evolutionarily ancient mediators of neuronal signalling that regulate a wide range of physiological processes and behaviours in animals. Neuropeptide signalling has been investigated extensively in vertebrates and protostomian invertebrates, which include the ecdysozoans Drosophila melanogaster (Phylum Arthropoda) and Caenorhabditis elegans (Phylum Nematoda). However, until recently, an understanding of evolutionary relationships between neuropeptide signalling systems in vertebrates and protostomes has been impaired by a lack of genome/transcriptome sequence data from non-ecdysozoan invertebrates...
April 21, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/28442678/frondoside-a-from-sea-cucumber-and-nymphaeols-from-okinawa-propolis-natural-anti-cancer-agents-that-selectively-inhibit-pak1-in-vitro
#9
Binh Cao Quan Nguyen, Kazuki Yoshimura, Shigenori Kumazawa, Shinkichi Tawata, Hiroshi Maruta
A sulfated saponin called "Frondoside A" (FRA) from sea cucumber and ingredients from Okinawa propolis (OP) have been previously shown to suppress the PAK1-dependent growth of A549 lung cancer as well as pancreatic cancer cells. However, the precise molecular mechanism underlying their anti-cancer action still remains to be clarified. In this study, for the first time, we found that both FRA and OP directly inhibit PAK1 in vitro in a selective manner (far more effectively than two other oncogenic kinases, LIMK and AKT)...
April 24, 2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/28433155/a-highly-regular-fucosylated-chondroitin-sulfate-from-the-sea-cucumber-massinium-magnum-structure-and-effects-on-coagulation
#10
Nadezhda E Ustyuzhanina, Maria I Bilan, Andrey S Dmitrenok, Elizaveta Yu Borodina, Valentin A Stonik, Nikolay E Nifantiev, Anatolii I Usov
A fucosylated chondroitin sulfate MM was isolated from the sea cucumber Massinium magnum. Structure of this polysaccharide was determined using chemical and NMR spectroscopic methods. The backbone of MM was shown to consist mainly of chondroitin sulfate E units with a small portion (about 10%) of chondroitin sulfate A fragments. Practically one type of branches Fuc3S4S attached to O-3 of GlcA residues was found in the polysaccharide molecules. The main repeating units of MM are →4)-[α-l-Fuc3S4S-(1→3)]-β-d-GlcA-(1→3)-β-d-GalNAc4S6S-(1→, whereas the minor repeating units are →4)-[α-l-Fuc3S4S-(1→3)]-β-d-GlcA-(1→3)-β-d-GalNAc4S-(1→...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28414789/effect-of-ph-on-temperature-controlled-degradation-of-reactive-oxygen-species-heat-shock-protein-expression-and-mucosal-immunity-in-the-sea-cucumber-isostichopus-badionotus
#11
Mariel Gullian Klanian, Montserrat Terrats Preciat
This study evaluated the effect of pH on the activity of antioxidant and immune enzymes in the sea cucumber Isostichopus badionotus exposed to different temperatures. The organisms (530 ±110 g) were exposed to 16, 20, 24, 28, 30, 34 and 36°C for 6 h to evaluate thermal limits at two water pH values (treatment = 7.70; control = 8.17). For the thermal tolerance experiment, the organisms were exposed to sublethal temperature of 34°C for 3, 6, 12, 24, and 48 h. I. badionotus showed signs of thermal stress by synthesizing heat shock protein 70 (hsp70) at the cold (16°C) and warm thermal limits (34°C)...
2017: PloS One
https://www.readbyqxmd.com/read/28407960/contributions-of-molecular-size-charge-distribution-and-specific-amino-acids-to-the-iron-binding-capacity-of-sea-cucumber-stichopus-japonicus-ovum-hydrolysates
#12
Na Sun, Pengbo Cui, Ziqi Jin, Haitao Wu, Yixing Wang, Songyi Lin
This study investigated the contributions of molecular size, charge distribution and specific amino acids to the iron-binding capacity of sea cucumber (Stichopus japonicus) ovum hydrolysates (SCOHs), and further explored their iron-binding sites. It was demonstrated that enzyme type and degree of hydrolysis (DH) significantly influenced the iron-binding capacity of the SCOHs. The SCOHs produced by alcalase at a DH of 25.9% possessed the highest iron-binding capacity at 92.1%. As the hydrolysis time increased, the molecular size of the SCOHs decreased, the negative charges increased, and the hydrophilic amino acids were exposed to the surface, facilitating iron binding...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28406733/cerebrosides-from-sea-cucumber-protect-against-oxidative-stress-in-samp8-mice-and-pc12-cells
#13
Hongxia Che, Lei Du, Peixu Cong, Suyuan Tao, Ning Ding, Fengjuan Wu, Changhu Xue, Jie Xu, Yuming Wang
Alzheimer's disease (AD) is a neurodegenerative disorder. Emerging evidence implicates β-amyloid (Aβ) plays a critical role in the progression of AD. In this study, we investigated the protective effect of cerebrosides obtained from sea cucumber against senescence-accelerated mouse prone 8 (SAMP8) mice in vivo. We also studied the effect of cerebrosides on Aβ-induced cytotoxicity on the rat pheochromocytoma cell (PC12) and the underlying molecular mechanisms. Cerebrosides ameliorated learning and memory deficits and the Aβ accumulation in demented mice, decreased the content of malondialdehyde (MDA), 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-OHdG), 8-hydroxy-2'-deoxyguanosine (8-oxo-G), and nitric oxide (NO), and enhanced the superoxide dismutase (SOD) activity significantly...
April 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28402186/inhibition-of-hafnia-alvei-h4-biofilm-formation-by-the-food-additive-dihydrocoumarin
#14
Hong Man Hou, Feng Jiang, Gong Liang Zhang, Jia Y Wang, Ya H Zhu, Xin Y Liu
Quorum sensing (QS) is an intercellular signaling and gene regulatory mechanism that is implicated in food spoilage caused by bacteria. Thus, blocking QS may suppress QS-controlled phenotypes of these bacteria that are responsible for food spoilage. Biofilm formation is closely related to bacterial infection, and it is also a major mechanism responsible for the increased resistance of biofilm-associated bacteria to antimicrobial drugs. Food spoilage and biofilm formation caused by food-related bacteria have posed a significant problem for the food industry...
April 12, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28397256/the-application-of-compound-specific-isotope-analysis-of-fatty-acids-for-traceability-of-sea-cucumber-apostichopus-japonicus-in-the-coastal-areas-of-china
#15
Yu Liu, Xufeng Zhang, Ying Li, Haixia Wang
BACKGROUND: Geographical origin traceability is an important issue in controlling the quality of seafood and in safeguarding the interest of consumers. In this study, a new method of compound-specific isotope analysis (CSIA) of fatty acids was established to evaluate its applicability in establishing the origin traceability of Apostichopus japonicus in the coastal areas of China. Principal component analysis (PCA) and discriminant analysis (DA) were applied to distinguish between origins of A...
April 10, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28395211/antioxidant-and-antiapoptotic-effects-of-sea-cucumber-and-valsartan-against-doxorubicin-induced-cardiotoxicity-in-rats-the-role-of-low-dose-gamma-irradiation
#16
Doaa M Ibrahim, Rasha R Radwan, Salma M Abdel Fattah
Doxorubicin (DOX) is a highly effective antineoplastic drug; however, the clinical use of DOX is limited by its dose dependent cardiotoxicity. This study was conducted to evaluate the cardioprotective effect of sea cucumber and valsartan against DOX-induced cardiotoxicity in rats. Also, the role of exposure to low dose γ radiation (LDR) on each of them was investigated, since LDR could suppress various reactive oxygen species-related diseases. Rats received DOX (2.5mg/kg, ip) in six equal injections over a period of 2weeks, sea cucumber (14...
March 31, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28392464/anticancer-and-cancer-preventive-compounds-from-edible-marine-organisms
#17
REVIEW
Marta Correia-da-Silva, Emília Sousa, Madalena M M Pinto, Anake Kijjoa
A direct impact of food on health, which demonstrates that dietary habit is one of the most important determinants of chronic diseases such as cancers, has led to an increased interest of the consumers toward natural bioactive compounds as functional ingredients or nutraceuticals. Epidemiological studies revealed that the populations of many Asian countries with high consumption of fish and seafood have low prevalence of particular type of cancers such as lung, breast, colorectal and prostate cancers. This observation has led to extensive investigations of the benefits of compounds present in edible marine organisms such as fish, marine invertebrates (mollusks, echinoderms) and marine algae as cancer chemopreventive agents...
April 6, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28379194/characteristics-of-n-acylhomoserine-lactones-produced-by-hafnia-alvei-h4-isolated-from-spoiled-instant-sea-cucumber
#18
Hong-Man Hou, Yao-Lei Zhu, Jia-Ying Wang, Feng Jiang, Wen-Yan Qu, Gong-Liang Zhang, Hong-Shun Hao
This study aimed to identify N-acylhomoserine lactone (AHL) produced by Hafnia alvei H4, which was isolated from spoiled instant sea cucumber, and to investigate the effect of AHLs on biofilm formation. Two biosensor strains, Chromobacterium violaceum CV026 and Agrobacterium tumefaciens KYC55, were used to detect the quorum sensing (QS) activity of H. alvei H4 and to confirm the existence of AHL-mediated QS system. Thin layer chromatography (TLC) and high resolution triple quadrupole liquid chromatography/mass spectrometry (LC/MS) analysis of the AHLs extracted from the culture supernatant of H...
April 5, 2017: Sensors
https://www.readbyqxmd.com/read/28373597/mechanical-adaptability-of-sea-cucumber-cuvierian-tubules-involves-a-mutable-collagenous-tissue
#19
Mélanie Demeuldre, Elise Hennebert, Marie Bonneel, Birgit Lengerer, Séverine Van Dyck, Ruddy Wattiez, Peter Ladurner, Patrick Flammang
Despite their soft body and slow motion, sea cucumbers present a low predation rate, reflecting the presence of efficient defence systems. For instance, members of the family Holothuriidae rely on Cuvierian tubules for their defence. These tubules are normally stored in the posterior coelomic cavity of the animal, but when the sea cucumber is threatened by a potential predator, they are expelled through the cloacal aperture, elongate, become sticky and entangle and immobilize the predator in a matter of seconds...
April 3, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28369350/draft-genome-of-the-sea-cucumber-apostichopus-japonicus-and-genetic-polymorphism-among-color-variants
#20
Jihoon Jo, Jooseong Oh, Hyun-Gwan Lee, Hyun-Hee Hong, Sung-Gwon Lee, Seongmin Cheon, Elizabeth M A Kern, Soyeong Jin, Sung-Jin Cho, Joong-Ki Park, Chungoo Park
The Japanese sea cucumber (Apostichopus japonicus Selenka 1867) is an economically important species as a source of seafood and ingredient in traditional medicine. It is mainly found off the coasts of northeast Asia. Recently, substantial exploitation and widespread biotic diseases in A. japonicus have generated increasing conservation concern. However, the genomic knowledge base and resources available for researchers to use in managing this natural resource and to establish genetically based breeding systems for sea cucumber aquaculture are still in a nascent stage...
January 1, 2017: GigaScience
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