Eliana Lingard, Siyuan Dong, Anna Hoyle, Ellen Appleton, Alis Hales, Eldhose Skaria, Craig Lawless, Isobel Taylor-Hearn, Simon Saadati, Qixun Chu, Aline F Miller, Marco Domingos, Alberto Saiani, Joe Swift, Andrew P Gilmore
Three-dimensional (3D) organoid models have been instrumental in understanding molecular mechanisms responsible for many cellular processes and diseases. However, established organic biomaterial scaffolds used for 3D hydrogel cultures, such as Matrigel, are biochemically complex and display significant batch variability, limiting reproducibility in experiments. Recently, there has been significant progress in the development of synthetic hydrogels for in vitro cell culture that are reproducible, mechanically tuneable, and biocompatible...
March 28, 2024: Biomater Adv