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https://www.readbyqxmd.com/read/28936791/nmda-receptors-and-no-cgmp-signaling-pathway-mediate-the-diazepam-induced-sensitization-to-withdrawal-signs-in-mice
#1
Sylwia Talarek, Joanna Listos, Jolanta Orzelska-Gorka, Anna Serefko, Jolanta Kotlińska
The goal of the present study was to examine the effects of N-methyl-aspartate (NMDA) receptor antagonists-memantine and ketamine and the drugs modifying the NO:cGMP pathway-NG-nitro-L-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI), the endogenous precursor of NO-L-arginine, and the guanylyl cyclase inhibitor-methylene blue (MB) on the development of sensitization to withdrawal signs precipitated after chronic, interrupted treatment with diazepam, a benzodiazepine receptor agonist, in mice. To develop the sensitization, the mice were divided into groups: continuously and sporadically (with two diazepam-free periods) treated with diazepam (15 mg/kg, sc)...
September 21, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28935606/calcimycin-mediates-mycobacterial-killing-by-inducing-intracellular-calcium-regulated-autophagy-in-a-p2rx7-dependent-manner
#2
Shradha Mawatwal, Assirbad Behura, Abhirupa Ghosh, Saqib Kidwai, Abtar Mishra, Amar Deep, Sakshi Agarwal, Sudipto Saha, Ramandeep Singh, Rohan Dhiman
Phenotypic screening led to the identification of calcimycin as a potent inhibitor of Mycobacterium bovis BCG (M. bovis BCG) growth in vitro and in THP-1 cells. In the present study, we aim to decipher the mechanism of antimycobacterial activity of calcimycin. We noticed that treatment with calcimycin led to up-regulation of different autophagy markers like Beclin-1, autophagy-related gene (Atg) 7, Atg 3 and enhanced microtubule-associated protein 1A/1B-light chain 3-I (LC3-I) to LC3-II conversion in macrophages...
September 18, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28935564/antinociception-induced-by-a-novel-%C3%AE-2a-adrenergic-receptor-agonist-in-rodents-acute-and-chronic-pain-models
#3
Roberto Takashi Sudo, Rachel Vieiralves do Amaral, Carlos Eduardo da Silva Monteiro, Ivan da Rocha Pitta, Maria do Carmo Lima, Guilherme Carneiro Montes, Douglas Gordon Ririe, Kenichiro Hayashida, Gisele Zapata-Sudo
The mechanisms and antinociceptive effects of a novel α2A adrenoceptor agonist, 3-(2-chloro-6-fluorobenzil)-imidazolinide-2,4-dione (PT-31) were investigated using animal models of acute and chronic pain. The effects of PT-31 on pain responses were examined using hot plate and formalin tests in mice and spinal nerve ligation (SNL)-induced hyperalgesia in rats. The effects of antagonists acting on α adrenoceptor were assessed to investigate the interaction of these pathways upon PT-31 induced antinociception...
September 18, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28935419/red-near-infrared-light-stimulates-release-of-an-endothelium-dependent-vasodilator-and-rescues-vascular-dysfunction-in-a-diabetes-model
#4
Agnes Keszler, Brian Lindemer, Dorothee Weihrauch, Deron Jones, Neil Hogg, Nicole L Lohr
Peripheral artery disease (PAD) is a morbid condition whereby ischemic peripheral muscle causes pain and tissue breakdown. Interestingly, PAD risk factors, e.g. diabetes mellitus, cause endothelial dysfunction secondary to decreased nitric oxide (NO) levels, which could explain treatment failures. Previously, we demonstrated 670nm light (R/NIR) increased NO from nitrosyl-heme stores, therefore we hypothesized R/NIR can stimulate vasodilation in healthy and diabetic blood vessels. Vasodilation was tested by ex vivo pressure myography in wild type C57Bl/6, endothelial nitric oxide synthase (eNOS) knockout, and db/db mice (10mW/cm(2) for 5min with 10min dark period)...
September 18, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28933109/-study-on-volatile-components-of-lonicerae-japonicae-flos-in-bud-stage-extended-type
#5
Jing-Ru Zhang, Gen-Ben Bai, Wei-Dong Li, Zhong-Shuang Zhang, Jin-Rui Gu, Cai-Qiao Zhang
Volatile components of Lonicerae Japonicae Flos in bud stage extended type Beihua 1 were determined by the headspace solid-phase micro-extraction, compared with traditional cultivar Damaohua. There are fifty-two volatile compounds were identified and the relative content of the volatiles was calculated by the area normalization method. Thirty-nine compounds were found in Beihua 1, whereas thirty-three components in Damaohua. Total twenty identical compounds existed in Beihua 1 and Damaohua. The contents of alcohols and hydrocarbons of Beihua 1 were higher significantly than that of Damaohua, while significantly lower than that of Damaohua in ketones content...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28931548/fluid-replacement-modulates-oxidative-stress-but-not-nitric-oxide-mediated-cutaneous-vasodilation-and-sweating-during-prolonged-exercise-in-the-heat
#6
Brendan D McNeely, Robert D Meade, Naoto Fujii, Andrew J E Seely, Ronald J Sigal, Glen P Kenny
The roles of nitric oxide synthase (NOS), reactive oxygen species (ROS) and angiotensin II type 1 receptor (AT1R) activation in regulating cutaneous vasodilation and sweating during prolonged (≥60 min) exercise are currently unclear. Moreover, it remains to be determined whether fluid replacement (FR) modulates the above thermoeffector responses. To investigate, eleven young men completed 90-min of continuous moderate intensity (46% of VO2peak) cycling performed at a fixed rate of metabolic heat production of 600 W (No-FR condition)...
September 20, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28929753/identification-of-%C3%AF-n-methyl-4-hydroxytryptamine-norpsilocin-as-a-psilocybe-natural-product
#7
Claudius Lenz, Jonas Wick, Dirk Hoffmeister
We report the identification of ω-N-methyl-4-hydroxytryptamine (norpsilocin, 1) from the carpophores of the hallucinogenic mushroom Psilocybe cubensis. The structure was elucidated by 1D and 2D NMR spectroscopy and high-resolution mass spectrometry. Norpsilocin has not previously been reported as a natural product. It likely represents the actual psychotropic agent liberated from its 4-phosphate ester derivative, the known natural product baeocystin. We further present a simple and artifact-free extraction method that prevents dephosphorylation and therefore helps reflect the naturally occurring metabolic profile of Psilocybe mushrooms in subsequent analyses...
September 20, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28929427/backbone-and-ile-%C3%AE-1-leu-val-methyl-1-h-15-n-and-13-c-chemical-shift-assignments-for-rhizopus-chinensis-lipase
#8
Meng Zhang, Xiao-Wei Yu, G V T Swapna, Gaohua Liu, Rong Xiao, Yan Xu, Gaetano T Montelione
Lipase r27RCL is a 296-residue, 33 kDa monomeric enzyme with high ester hydrolysis activity, which has significant applications in the baking, paper and leather industries. The lipase gene proRCL from Rhizopus microsporus var. chinensis (also Rhizopus chinensis) CCTCC M201021 was cloned as a fusion construct C-terminal to a maltose-binding protein (MBP) tag, and expressed as MBP-proRCL in an Escherichia coli BL21 trxB (DE3) expression system with uniform (2)H,(13)C,(15)N-enrichment and Ile-δ1, Leu, and Val (13)CH3 methyl labeling...
September 19, 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28928475/isolation-of-the-antibiotic-methyl-r-e-3-1-hydroxy-4-oxocyclopent-2-en-1-yl-acrylate-ea-2801-from-trichoderma-atroviridae
#9
Emilie Adelin, Géraldine Le Goff, Pascal Retailleau, Mercedes Bonfill, Jamal Ouazzani
The endophytic Trichoderma atroviridae UB-LMA was isolated as a symbiont of Taxus baccata and analyzed for its antimicrobial activity. By applying an original approach consisting of solid-state cultivation coupled with solid-phase extraction, a new methyl (R,E)-3-(1-hydroxy-4-oxocyclopent-2-en-1-yl)-acrylate derivative named EA-2801 (1) was isolated together with the previously reported isonitrin A and dermadin methyl ester. The chemical structure of 1 was determined by NMR and MS. Compound 1 showed antimicrobial activity against a panel of Gram-positive and -negative bacteria...
September 20, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28925705/incoherent-pathways-of-charge-separation-in-organic-hybrid-solar-cells
#10
Alexander Grupp, Philipp Ehrenreich, Julian Kalb, Arne Budweg, Lukas Schmidt-Mende, Daniele Brida
In this work, we investigate the exciton dissociation dynamics occurring at the donor-acceptor interface in organic and hybrid blends employed in the realization of photovoltaic cells. Fundamental differences in the charge separation process are studied with the organic semiconductor polymer poly(3-hexylthiophene) (P3HT) and either [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) or titanium dioxide (TiO2) acting as acceptor. By using ultrafast broadband transient absorption spectroscopy with few-fs temporal resolution, we observe that in both cases the incoherent formation of free charges is dominating the charge generation process...
September 19, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28924081/comparative-antileukemic-activity-of-a-tetranorditerpene-isolated-from-polyalthia-longifolia-leaves-and-the-derivative-against-human-leukemia-hl-60-cells
#11
Saheed Afolabi, Olufunke Olorundare, Masayuki Ninomiya, Abiola Babatunde, Hasan Mukhtar, Mamoru Koketsu
The discovery of potent cytotoxic isolates from botanicals provides an opportunity to explore this viable tool for cancer chemoprevention. The antileukemic potential of clerodane diterpene from Polyalthia longifolia leaves has already been established. However, in this present study, utilizing chromatographic techniques we report for the first time, the isolation of a rare tetranorditerpene (compound 1) from P. longifolia. The structure of compound 1 was elucidated and confirmed by spectrophotometric data. UPLC-MS analysis was conducted on the methanolic extract, ethyl acetate fraction, and isolated tetranorditerpene showed that the tetranorditerpene is one of the major constituents of the plant with a retention time of 30...
September 15, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28923563/characterization-antioxidant-and-antiglycation-properties-of-polysaccharides-extracted-from-the-medicinal-halophyte-carpobrotus-edulis-l
#12
Jawhar Hafsa, Khaoula Mkadmini Hammi, Didier Le Cerf, Khalifa Limem, Hatem Majdoub, Bassem Charfeddine
In this study, Box-Behnken design was used to optimize the ultrasonic extraction of Carpobrotus edulis polysaccharides (CEP), and the effect of time, extraction temperature and water to material ratio was evaluated. Optimum conditions were 1.77h, 78.0°C and 33.04mL/g to improved CEP yield (7.84%), which is in good agreement with the predicted yield 7.77%. Then, the physico-chemical, antioxidant and antiglycation properties of optimized CEP were studied, and the total sugar and galacturonic acid content were 89...
September 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28923388/synthesis-of-cytotoxically-active-derivatives-based-on-alkylated-2-3-seco-triterpenoids
#13
Anastasia V Konysheva, Vladimir O Nebogatikov, Irina A Tolmacheva, Maxim V Dmitriev, Victoria V Grishko
Extremely low content of biologically active triterpenoids with the fragmented or contracted ring A extractable from plants is the main disadvantage of their use in drug discovery and practical pharmacology. Development of new methods for synthesis of these compounds and their structural analogs from bioavailable triterpene precursors gives an opportunity to obtain promising agents for pharmacology with excellent yields. A new approach to synthesis of alkylated A-seco-triterpenoids, including the Beckmann fragmentation of 3-methyl-substituted allobetulin or betulinic acid methyl ester with 2-hydroxyimino group in the ring A was proposed...
September 6, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28921217/effect-of-lower-and-higher-alcohol-fuel-synergies-in-biofuel-blends-and-exhaust-treatment-system-on-emissions-from-ci-engine
#14
Thiyagarajan Subramanian, Edwin Geo Varuvel, Leenus Jesu Martin, Nagalingam Beddhannan
The present study deals with performance, emission and combustion studies in a single cylinder CI engine with lower and higher alcohol fuel synergies with biofuel blends and exhaust treatment system. Karanja oil methyl ester (KOME), widely available biofuel in India, and orange oil (ORG), a low carbon biofuel, were taken for this study, and equal volume blend was prepared for testing. Methanol (M) and n-pentanol (P) was taken as lower and higher alcohol and blended 20% by volume with KOME-ORG blend. Activated carbon-based exhaust treatment indigenous system was designed and tested with KOME-ORG + M20 and KOME-ORG + P20 blend...
September 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28920691/pyruvate-enolate-arylation-and-alkylation-obo-ester-protected-pyruvates-as-useful-reagents-in-organic-synthesis
#15
C Henrique Alves Esteves, Christopher J J Hall, Peter D Smith, Timothy J Donohoe
A protected pyruvate equivalent is described that allows arylation and arylation/alkylation reactions to be performed at the methyl group. Utilization of the OBO derivative of the pyruvate ester allowed the application of palladium catalyzed arylation reactions together with subsequent alkylation, under basic conditions. Moreover, the OBO protecting group could be easily removed in one step to provide access to a wide range of substituted pyruvate derivatives.
September 18, 2017: Organic Letters
https://www.readbyqxmd.com/read/28920570/brain-relevant-antibodies-in-first-episode-psychosis-a-matched-case-control-study
#16
Fiona Gaughran, John Lally, Katherine Beck, Ruaidhri McCormack, Poonam Gardner-Sood, Ester Coutinho, Leslie Jacobson, Bethan Lang, Ricardo Sainz-Fuertes, Evangelos Papanastasiou, Marta Di Forti, Tim Nicholson, Angela Vincent, Robin M Murray
BACKGROUND: There has been much recent excitement about the possibility that some cases of psychosis may be wholly due to brain-reactive antibodies, with antibodies to N-methyl-D-aspartate receptor (NMDAR) and the voltage-gated potassium channel (VGKC)-complex reported in a few patients with first-episode psychosis (FEP). METHODS: Participants were recruited from psychiatric services in South London, UK, from 2009 to 2011 as part of the Genetics and Psychosis study...
September 18, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28920447/synthesis-and-cytotoxic-activity-of-4-o-%C3%AE-d-galactopyranosyl-derivatives-of-phenolic-acids-esters
#17
Nader Al Bujuq, Sharif Arar, Raida Khalil
The glycosylation of naturally occurring phenolic acids has a significant impact on their solubility, stability and physiochemical properties. D-Galactose residue was found to form a part of glycoconjugates in several tissues and involved in a variety of physiological process. To the best of our knowledge, we have noticed a little information about the glycosylation of the phenolic acids with galactose residue. In this work, we describe the glycosylation of methyl vanillate and methyl ferulate with peracetylated-β-D-galactopyranose in the presence of BF3·OEt2...
September 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28918245/biodiesel-production-from-lipid-of-carbon-dioxide-sequestrating-bacterium-and-lipase-of-psychrotolerant-pseudomonas-sp-istpl3-immobilized-on-biochar
#18
Khushboo Khosla, Rashmi Rathour, Raj Maurya, Neha Maheshwari, Edgard Gnansounou, Christian Larroche, Indu Shekhar Thakur
An extracellular lipase was purified and characterized from psychrotolerant bacterium Pseudomonas sp. ISTPL3 isolated from Pangong lake. Lipase was purified by sequential methods of ammonium sulphate precipitation, dialysis, DEAE-cellulose ion exchange chromatography and Sephadex G-100 gel filtration chromatography, resulting in a purification fold of 6.53 and yield of 5.45%. The molecular weight was approximately 31kDa. The purified lipase was used for transesterification of lipids produced by oleaginous chemolithotrophic bacterium Serratia sp...
September 1, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28917186/compounds-isolated-from-eriobotrya-deflexa-leaves-protect-against-ultraviolet-radiation-b-induced-photoaging-in-human-fibroblasts
#19
Chung-Yu Huang, Yi-Tzu Lin, Hsiang-Chun Kuo, Wen-Fei Chiou, Mei-Hsien Lee
Ultraviolet (UV) irradiation leads to skin photoaging because of the upregulation of matrix metalloproteinase (MMP)-1 and downregulation of type I collagen and tissue inhibitor of metalloproteinase (TIMP)-1. Eriobotrya deflexa (Hemsl.) Nakai (Rosaceae) is a flowering plant endemic to Taiwan, and its leaves have been used as an expectorant and in antitussive folk remedy. Our previous studies have demonstrated that an E. deflexa leaf extract functions as a free radical scavenger. The current evaluated the antiphotoaging effect of partitioned fractions and specific compounds from the leaves of E...
September 4, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28917145/cell-wall-pectin-methyl-esterification-and-organic-acids-of-root-tips-involve-in-aluminum-tolerance-in-camellia-sinensis
#20
Dongqin Li, Zaifa Shu, Xiaoli Ye, Jiaojiao Zhu, Junting Pan, Weidong Wang, Pinpin Chang, Chuanlei Cui, Jiazhi Shen, Wanping Fang, Xujun Zhu, Yuhua Wang
Tea plant (Camellia sinensis (O.) Kuntze) can survive from high levels of aluminum (Al) in strongly acidic soils. However, the mechanism driving its tolerance to Al, the predominant factor limiting plant growth in acid condition, is still not fully understood. Here, two-year-old rooted cuttings of C. sinensis cultivar 'Longjingchangye' were used for Al resistance experiments. We found that the tea plants grew better in the presence of 0.4 mM Al than those grew under lower concentration of Al treatments (0 and 0...
September 7, 2017: Plant Physiology and Biochemistry: PPB
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