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Millee Singh, Anne Kroman, Juile Singh, Hassan Tariq, Shetal Amin, Cesar Alberto Morales-Pablon, Kristina Vanessa Cahill, Eric Edward Harrison
OBJECTIVE: We sought to characterize the risk of a heart attack in a 48-year-old asymptomatic US Special Operations Command (SOCOM) Soldier without known coronary artery disease (CAD). BACKGROUND: CAD continues to be a leading cause of morbidity and mortality among most age groups in the United States. Much research is dedicated to establishing new techniques to predict myocardial infarction (MI). METHODS: Coronary computed tomography (CT) angiography, also known as CCTA, along with 7-protein serum biomarker risk assessment was performed for risk evaluation...
2015: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Deeptak Verma, Gevorg Grigoryan, Chris Bailey-Kellogg
The development of protein variants with improved properties (thermostability, binding affinity, catalytic activity, etc.) has greatly benefited from the application of high-throughput screens evaluating large, diverse combinatorial libraries. At the same time, since only a very limited portion of sequence space can be experimentally constructed and tested, an attractive possibility is to use computational protein design to focus libraries on a productive portion of the space. We present a general-purpose method, called "Structure-based Optimization of Combinatorial Mutagenesis" (SOCoM), which can optimize arbitrarily large combinatorial mutagenesis libraries directly based on structural energies of their constituents...
May 2015: Protein Science: a Publication of the Protein Society
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