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Abhimanyu Sharma, Priyanka Gogoi, Rajesh Arora, Rehan Ul Haq, Ish Kumar Dhammi, Shuchi Bhatt
Osteoblastoma is a rare tumor and represents about 0.8% of all bone tumors. The aggressive variant is even rarer and difficult to diagnose. We present a case of a 17 year old male with a tumor of the acetabulum with characteristic epithelioid osteoblasts and other features of an aggressive osteoblastoma. It is important to recognize this entity as it can be clinically confused with an osteosarcoma. Our case not only showed epithelioid morphology but also had vacuolated cytoplasm, which simulated a mucin secreting adenocarcinoma...
June 2018: Journal of Clinical Orthopaedics and Trauma
Sean J Buckley, Peter Timms, Mark R Davies, David J McMillan
Bacteria respond to environmental changes through the co-ordinated regulation of gene expression, often mediated by two-component regulatory systems (TCS). Group A Streptococcus (GAS), a bacterium which infects multiple human body sites and causes multiple diseases, possesses up to 14 TCS. In this study we examined genetic variation in the coding sequences and non-coding DNA upstream of these TCS as a method for evaluating relationships between different GAS emm-types, and potential associations with GAS disease...
2018: PloS One
Gillian Elliott, Kathleen Pheasant, Katja Ebert-Keel, Julianna Stylianou, Ashley Franklyn, Juliet Jones
The HSV1 virion host shutoff (vhs) protein is an endoribonuclease that binds to the cellular translation initiation machinery and degrades associated mRNAs, resulting in shut-off of host protein synthesis. Hence its unrestrained activity is considered to be lethal, and it has been proposed that vhs is regulated by two other virus proteins, VP22 and VP16. We have found that during infection, translation of vhs requires VP22 but not the VP22-VP16 complex. Moreover, in the absence of VP22, vhs is not overactive against cellular or viral transcripts...
June 20, 2018: Journal of Virology
Moritz Bömer, José A O'Brien, Imma Pérez-Salamó, Jovaras Krasauskas, Paul Finch, Andrea Briones, Arsalan Daudi, Puneet Souda, Tjir-Li Tsui, Julian P Whitelegge, G Paul Bolwell, Alessandra Devoto
Background and Aims: Cultured cell suspensions have been the preferred model to study the apoplast as well as to monitor metabolic and cell cycle-related changes. Previous work showed that methyl jasmonate (MeJA) inhibits leaf growth in a CORONATINE INSENSITIVE 1 (COI1)-dependent manner, with COI1 being the jasmonate (JA) receptor. Here, the effect of COI1 overexpression on the growth of stably transformed arabidopsis cell cultures is described. Methods: Time-course experiments were carried out to analyse gene expression, and protein and metabolite levels...
June 19, 2018: Annals of Botany
Reham M Nada, Abdel Hamid A Khedr, Mamdouh S Serag, Nesma R El-Qashlan, Gaber M Abogadallah
Under high water availability, the maximum gas exchange was observed at noon in the expanding and expanded leaves. The expanded leaves showed lower gas exchange capacity due to the regulation of stomatal-movement genes. Under well-watered condition, stomatal conductance (gs ) and photosynthetic rate (A) of expanding and expanded leaves of Atriplex halimus peaked at noon despite the midday decline in the leaf relative water content, suggesting deviation from typical isohydric behaviour. However, the expanding leaves had higher gs and A than the expanded ones...
June 19, 2018: Planta
Susie Donnelly, Brenda Reginatto, Oisin Kearns, Marie Mc Carthy, Bill Byrom, Willie Muehlhausen, Brian Caulfield
BACKGROUND: Despite an aging population, older adults are typically underrecruited in clinical trials, often because of the perceived burden associated with participation, particularly travel associated with clinic visits. Conducting a clinical trial remotely presents an opportunity to leverage mobile and wearable technologies to bring the research to the patient. However, the burden associated with shifting clinical research to a remote site requires exploration. While a remote trial may reduce patient burden, the extent to which this shifts burden on the other stakeholders needs to be investigated...
June 19, 2018: Journal of Medical Internet Research
Sharon Keesing, Lorna Rosenwax, Beverley McNamara
AIM: Survivorship is an under-recognized period in the care of women with breast cancer. This paper aimed to determine if supports provided by health services were adequate in meeting the expressed needs of women and partners during survivorship. METHODS: A mixed method study consisted of: (1) in-depth interviews with women (n = 18) and partners (n = 8), (completed June 2014-November 2014) and (2) a questionnaire with health providers (n = 34) (completed April 2015) regarding services offered, needs addressed and barriers to service delivery...
June 19, 2018: Women & Health
Laura Pellegrini, David N Hauser, Yan Li, Adamantios Mamais, Alexandra Beilina, Ravindran Kumaran, Andrea Wetzel, George Heaton, Iakov Rudenko, Mor Alkaslasi, Natalie Ivanina, Heather L Melrose, Mark R Cookson, Kirsten Harvey
Mutations in leucine-rich repeat kinase 2 (LRRK2) segregate with familial Parkinson's disease (PD) and genetic variation around LRRK2 contributes to risk of sporadic disease. Although knockout of LRRK2 or knock-in of pathogenic mutations into the mouse germline does not result in a PD phenotype, several defects have been reported in the kidneys of LRRK2 knockout mice. To understand LRRK2 function in vivo, we used an unbiased approach to determine which protein pathways are affected in LRRK2 knockout kidneys...
June 18, 2018: Human Molecular Genetics
Julie MacInnes, Liz Williams
AimThe aim of this integrative review is to determine the effectiveness of integrated heart failure (HF) care in terms of patient-, service- and resource-related outcomes, and to determine what model or characteristics of integrated care work best, for whom and in what contexts. BACKGROUND: Integration of health and social care services is a significant driver in the development of better and more cost-effective health and social care systems in Europe and developed countries. As high users of health and social care services, considerable attention has been paid to the care of people with long-term conditions...
June 18, 2018: Primary Health Care Research & Development
James H Crichton, David Read, Ian R Adams
Recombination, synapsis, chromosome segregation and gene expression are co-ordinately regulated during meiosis to ensure successful execution of this specialised cell division. Studies with multiple mutant mouse lines have shown that mouse spermatocytes possess quality control checkpoints that eliminate cells with persistent defects in chromosome synapsis. In addition, studies on Trip13 mod/mod mice suggest that pachytene spermatocytes that successfully complete chromosome synapsis can undergo meiotic arrest in response to defects in recombination...
June 16, 2018: Chromosoma
Adebanji S Ogbiye, Olumuyiwa O Onakunle, David O Omole
The dataset analyzed in this article contains spatial and temporal values of the hydro-geometric parameters of River Atuwara. The hydro-geometrical data analyses of various sampling point on River Atuwara was examined and their geometric properties were taken with the use of a paddled boat, depth meter and global positioning system (GPS). The co-ordinates, width, depth, slopes, area, velocity, flow were gotten in-situ while the area and wetted perimeter were computed ex-situ. The statistical relationships between separate variables were considered using scatter plots and regression line equations...
June 2018: Data in Brief
Joseph J Palamar, Austin Le, Pedro Mateu-Gelabert
BACKGROUND: Heroin-related deaths are on the rise in the US and a large portion of heroin overdoses involve co-use of other drugs such as benzodiazepines. A better understanding of heroin polysubstance use patterns could help discern better prevention measures. METHODS: Data were examined from past-month ("current") heroin users from a nationally representative sample of high school seniors in the Monitoring the Future study (2010-2016, n = 327). We examined how past-month use and frequency of use of various drugs relate to frequency of current heroin use using chi-square and multivariable ordinal logistic regression...
May 30, 2018: Drug and Alcohol Dependence
Sara Frost, Samuel Guérin, Brian Elliott Hayden, Jean-Philippe Soulié, Chris Vian
High-Throughput techniques have been employed for the synthesis and characterisation of thin film phosphors of Eu doped BaxSr2-xSiO4. Direct synthesis from evaporation of the constituent elements under a flux of atomic oxygen on a sapphire substrate at 850 °C was used to directly produce thin film libraries (415 nm thickness) of the crystalline orthosilicate phase with the desired compositional variation (0.24 > x > 1.86). The orthosilicate phase could be synthesised as a pure, or predominantly pure, phase...
June 7, 2018: ACS Combinatorial Science
Shun Han, Xiang Li, Xuesong Luo, Shilin Wen, Wenli Chen, Qiaoyun Huang
Nitrification is the two-step aerobic oxidation of ammonia to nitrate via nitrite in the nitrogen-cycle on earth. However, very limited information is available on how fertilizer regimes affect the distribution of nitrite oxidizers, which are involved in the second step of nitrification, across aggregate size classes in soil. In this study, the community compositions of nitrite oxidizers ( Nitrobacter and Nitrospira ) were characterized from a red soil amended with four types of fertilizer regimes over a 26-year fertilization experiment, including control without fertilizer (CK), swine manure (M), chemical fertilization (NPK), and chemical/organic combined fertilization (MNPK)...
2018: Frontiers in Microbiology
Kate Radford, Chris Sutton, Tracey Sach, Jain Holmes, Caroline Watkins, Denise Forshaw, Trevor Jones, Karen Hoffman, Rory O'Connor, Ruth Tyerman, Jose Antonio Merchán-Baeza, Richard Morris, Emma McManus, Avril Drummond, Marion Walker, Lelia Duley, David Shakespeare, Alison Hammond, Julie Phillips
BACKGROUND: Up to 160,000 people incur traumatic brain injury (TBI) each year in the UK. TBI can have profound effects on many areas of human functioning, including participation in work. There is limited evidence of the clinical effectiveness and cost-effectiveness of vocational rehabilitation (VR) after injury to promote early return to work (RTW) following TBI. OBJECTIVE: To assess the feasibility of a definitive, multicentre, randomised controlled trial (RCT) of the clinical effectiveness and cost-effectiveness of early, specialist VR plus usual care (UC) compared with UC alone on work retention 12 months post TBI...
May 2018: Health Technology Assessment: HTA
Ankita Shrestha, Ahamed Khan, Nrisingha Dey
Co-ordinated transcriptional control employing synthetic promoters and transcription factors (TFs) can be used to achieve customized gene expression regulation in planta. Synthetic promoter technology has yielded a series of promoters with modified cis-regulatory elements that provide useful tools for efficient modulation of gene expression. In addition, the use of zinc fingers (ZFs), transcription activator-like effectors (TALEs), and catalytically inactive clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (dCas9) has made it feasible to engineer TFs that can produce targeted gene expression regulation; these approaches are particularly effective when artificial TFs are coupled with transcriptional activators or repressors...
May 30, 2018: Molecular Plant
Margaret I Fitch, Fred Ashbury, Irene Nicoll
BACKGROUND: Accreditation bodies in the USA, the UK, and Europe have mandated that jurisdictions regularly screen patients for distress. While these requirements have been in place for some time, recent reports suggest that facilities still struggle to overcome implementation barriers. In Canada, a Screening for Distress (the sixth vital sign) Initiative was implemented in eight cancer treatment facilities in seven provinces. With national support and coordination from the Canadian Partnership Against Cancer, the initiative's primary goal was to provide timely and appropriate response to cancer patients' distress to improve the patient experience...
June 1, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Minakshi Ghate, N Thejo Kalyani, S J Dhoble
This paper reports the synthesis and characterization of 2-(4-ethoxyphenyl)-4-phenyl quinoline (OEt-DPQ) organic phosphor using an acid-catalyzed Friedlander reaction and the preparation of blended thin films by molecularly doping OEt-DPQ in poly(methyl methacrylate) (PMMA) at different wt%. The molecular structure of the synthesized phosphor was confirmed by Fourier transform infra-red (FTIR) spectroscopy and nuclear magnetic resonance spectra (NMR). Surface morphology and percent composition of the elements were assessed by scanning electron microscopy (SEM) and energy dispersive analysis of X-rays (EDAX)...
May 31, 2018: Luminescence: the Journal of Biological and Chemical Luminescence
Narelle Hadlow, Suzanne Brown, Robert Wardrop, Johan Conradie, David Henley
OBJECTIVE: Cortisol is a critical stress hormone with circadian rhythms synchronized by light. There are seasonal differences in expression of pro-inflammatory genes and in some diseases moderated by glucocorticoids. As light changes with season and with latitude and longitude, we assessed changes in population cortisol associated with these parameters. DESIGN: Retrospective data audit. PATIENTS: Populations across four states of Australia over three years...
May 30, 2018: Clinical Endocrinology
Brent A Lanting, Thomas J Wood, Sam Young, Douglas W Van Citters, Steven J MacDonald, James L Howard, Matthew G Teeter
INTRODUCTION: Corrosion at head neck taper junctions in total hip arthroplasty has increasingly been reported in the literature. Debate persists as to the exact causes and clinical significance of corrosion. Increased offset and head length has been correlated with an increased risk of tribocorrosion due to an adverse mechanical environment. The purpose of this study is to assess the effect of head length on corrosion of a metal-on-polyethylene articulation. METHODS: Retrievals from a single institution of 28-mm cobalt chromium alloy heads with a 12/14 taper from a single manufacturer were studied...
May 1, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
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