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https://www.readbyqxmd.com/read/28231437/classification-of-organic-beef-freshness-using-vnir-hyperspectral-imaging
#1
Stuart O J Crichton, Sascha M Kirchner, Victoria Porley, Stefanie Retz, Gardis von Gersdorff, Oliver Hensel, Martin Weygandt, Barbara Sturm
Consumer trust in the food industry is heavily reliant upon accurate labelling of meat products. As such, methods, which can verify whether meat is correctly labelled are of great value to producers, retailers, and consumers. This paper illustrates two approaches to classify between, fresh and frozen thawed, and in a novel manner matured and matured frozen-thawed, as well as fresh and matured beef using the 500-1010nm waveband, captured using hyperspectral imaging, and CIELAB measurements. The results show successful classification based upon CIELAB between 1) fresh and frozen-thawed (CCR=0...
February 8, 2017: Meat Science
https://www.readbyqxmd.com/read/28229230/mycobacterium-ulcerans-mycolactone-interferes-with-adhesion-migration-and-proliferation-of-primary-human-keratinocytes-and-hacat-cell-line
#2
Francesca Graziola, Elena Colombo, Rossana Tiberio, Giorgio Leigheb, Chiarella Bozzo
The pathogenicity of Mycobacterium ulcerans (Buruli ulcer) is closely associated with the secretion of exotoxin mycolactone. The cytotoxicity of mycolactone has been linked to its apoptogenic activity. We explored if low mycolactone concentrations, which are not able to induce apoptosis, can influence other essential activities on two primary human keratinocyte populations, keratinocyte stem cells (KSC) and transit amplifying cells (TAC), and on a human keratinocyte line, HaCaT. We demonstrated that 0.01 and 0...
February 22, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28227364/a-method-to-quantify-co-localization-in-biological-images
#3
Shiwen Zhu, Roy E Welsch, Paul T Matsudaira, Shiwen Zhu, Roy E Welsch, Paul T Matsudaira, Roy E Welsch, Paul T Matsudaira, Shiwen Zhu
Quantitative co-localization analysis with fluorescent microscopy is a common approach to assess the spatial co-ordination of molecules and thus to understand their functions in biological processes. However, the co-localization analysis results might not be consistent due to various imaging conditions and different quantification methods used. We propose a novel method to separate a co-localization event into two aspects: co-occurrence and intensity correlation, which are usually combined as one parameter in other quantitative co-localization analyses...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222271/pathways-to-lung-cancer-diagnosis-a-qualitative-study-of-patients-and-general-practitioners-about-diagnostic-and-pre-treatment-intervals
#4
Nicole M Rankin, Sarah York, Emily Stone, David Barnes, Deborah McGregor, Michelle Lai, Tim Shaw, Phyllis N Butow
RATIONALE: Pathways to lung cancer diagnosis and treatment are complex. International evidence shows significant variations in pathways. Qualitative research investigating pathways to lung cancer diagnosis rarely considers both patient and general practitioner views simultaneously. OBJECTIVES: To describe the lung cancer diagnostic pathway, focusing on the perspective of patients and general practitioners about diagnostic and pre-treatment intervals. METHODS: This qualitative study of lung cancer patients and general practitioners in Australia used qualitative interviews or a focus group in which participants responded to a semistructured questionnaire designed to explore experiences of the diagnostic pathway...
February 21, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28219746/application-of-high-throughput-sequencing-to-whole-rabies-viral-genome-characterisation-and-its-use-for-phylogenetic-re-evaluation-of-a-raccoon-strain-incursion-into-the-province-of-ontario
#5
Susan A Nadin-Davis, Adam Colville, Hannah Trewby, Roman Biek, Leslie Real
Raccoon rabies remains a serious public health problem throughout much of the eastern seaboard of North America due to the urban nature of the reservoir host and the many challenges inherent in multi-jurisdictional efforts to administer co-ordinated and comprehensive wildlife rabies control programmes. Better understanding of the mechanisms of spread of rabies virus can play a significant role in guiding such control efforts. To facilitate a detailed molecular epidemiological study of raccoon rabies virus movements across eastern North America, we developed a methodology to efficiently determine whole genome sequences of hundreds of viral samples...
February 17, 2017: Virus Research
https://www.readbyqxmd.com/read/28219445/a-cross-sectional-study-of-the-income-sources-of-primary-care-health-workers-in-the-democratic-republic-of-congo
#6
Rishma Maini, David R Hotchkiss, Josephine Borghi
BACKGROUND: In the Democratic Republic of Congo (DRC), the state system to remunerate health workers is poorly functional, encouraging diversification of income sources and corruption. Given the central role that health workers play in health systems, policy-makers need to ensure health workers are remunerated in a way which best incentivises them to provide effective and good quality services. This study describes the different sources and quantities of income paid to primary care health workers in Equateur, Maniema, Kasai Occidental, Province Orientale and Kasai Oriental provinces...
February 20, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28209523/tb-iris-proteomic-analysis-of-in-vitro-pbmc-responses-to-mycobacterium-tuberculosis-and-response-modulation-by-dexamethasone
#7
Liam Bell, Janique M Peyper, Shaun Garnett, Rabecca Tadokera, Robert Wilkinson, Graeme Meintjes, Jonathan M Blackburn
Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) occurs in 8-54% of South African patients undergoing treatment for tuberculosis/human immunodeficiency virus co-infection. Improved TB-IRIS molecular pathogenesis understanding would enhance risk stratification, diagnosis, prognostication, and treatment. We assessed how TB-IRIS status and dexamethasone influence leukocyte proteomic responses to Mycobacterium tuberculosis (Mtb). Patient blood was obtained three weeks post-anti-retroviral therapy initiation...
February 14, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28208939/the-effects-of-spiritual-self-care-training-on-caregiving-strain-in-mothers-of-mentally-retarded-children
#8
Mitra Dindar, Mozhgan Rahnama, Mehdi Afshari, Mahdieh Poodineh Moghadam
INTRODUCTION: Care for a mentally retarded child induces a lot of problems for the mother and leads her to care giving strain and ignorning her self-care. Spiritual health will co-ordinate all aspects of human life and is necessary for coping with diseases in mother of mentally retarded children. AIM: To evaluate the effects of spiritual self-care training on care giving strain in mothers of mentally retarded children. MATERIALS AND METHODS: The present study, is a before and after type quasi-experimental research based on which 60 mothers of mentally retarded children who were hospitalized in Elahi Rehabilitation Center in Quchan City, were selected using convenience sampling and were randomly assigned to intervention and control groups...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28202678/stress-induced-o-glcnacylation-an-adaptive-process-of-injured-cells
#9
REVIEW
Marissa R Martinez, Thiago Braido Dias, Peter S Natov, Natasha E Zachara
In the 30 years, since the discovery of nucleocytoplasmic glycosylation, O-GlcNAc has been implicated in regulating cellular processes as diverse as protein folding, localization, degradation, activity, post-translational modifications, and interactions. The cell co-ordinates these molecular events, on thousands of cellular proteins, in concert with environmental and physiological cues to fine-tune epigenetics, transcription, translation, signal transduction, cell cycle, and metabolism. The cellular stress response is no exception: diverse forms of injury result in dynamic changes to the O-GlcNAc subproteome that promote survival...
February 8, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/28193462/both-canonical-and-noncanonical-wnt-signalling-may-be-required-for-detoxification-following-etp-class-mycotoxin-exposure
#10
Jinbi Zhang, Zengxiang Pan, Allan Sheppard
Fungal infections (mycotoxicoses) are a growing global threat for both health and food production, and the available tools for effective detection, monitoring and treatment remain limited. Mycotoxins of the so-called ETP class can cause disease in humans (notably immunocompromised clinical patients) and otherwise healthy ruminant production animals. Understanding the molecular responses caused by ETP toxicity responses will inform diagnostics and guide possible interventions. Here we provide empirical evidence that exposure of hepatic cells to the ETP mycotoxin Sporidesmin A may trigger both canonical and noncanonical Wnt signalling, mediated through miRNA regulation, and regulate the particular expression of CYP2C family members...
February 10, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28183168/effects-of-alfalfa-flavonoids-extract-on-the-microbial-flora-of-dairy-cow-rumen
#11
Jinshun Zhan, Mingmei Liu, Caixia Wu, Xiaoshuang Su, Kang Zhan, Guo Qi Zhao
Objective: The effect of flavonoids from alfalfa on the microbial flora was determined using molecular techniques of 16S ribosome deoxyribonucleic acid (rDNA) analysis. Methods:Four primiparous Holstein heifers fitted with ruminal cannulas were used in a 4 × 4 Latin square design and fed a total mixed ration (TMR) to which alfalfa flavonoids extract (AFE) was added at the rates of 0 (A, control), 20 (B), 60 (C) or 100 (D) mg per kg of heifer body weight (BW) . Results: The number of OTUs in heifers given higher levels of flavonoid extract (C and D) was higher than for the two other treatments...
February 1, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28174774/bipyridine-based-metallogels-an-unprecedented-difference-in-photochemical-and-chemical-reduction-in-the-in-situ-nanoparticle-formation
#12
Rajendhraprasad Tatikonda, Kia Bertula, Nonappa, Sami Hietala, Kari Rissanen, Matti Haukka
Metal co-ordination induced supramolecular gelation of low molecular weight organic ligands is a rapidly expanding area of research due to the potential in creating hierarchically self-assembled multi-stimuli responsive materials. In this context, structurally simple O-methylpyridine derivatives of 4,4'-dihydroxy-2,2'-bipyridine ligands are reported. Upon complexation with Ag(i) ions in aqueous dimethyl sulfoxide (DMSO) solutions the ligands spontaneously form metallosupramolecular gels at concentrations as low as 0...
February 8, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28173929/postflight-reconditioning-for-european-astronauts-a-case-report-of-recovery-after-six-months-in-space
#13
Nora Petersen, Gunda Lambrecht, Jonathan Scott, Natalie Hirsch, Maria Stokes, Joachim Mester
BACKGROUND: Postflight reconditioning of astronauts is understudied. Despite a rigorous, daily inflight exercise countermeasures programme during six months in microgravity (μG) on-board the International Space Station (ISS), physiological impairments occur and postflight reconditioning is still required on return to Earth. Such postflight programmes are implemented by space agency reconditioning specialists. Case Description and Assessments: A 38 year old male European Space Agency (ESA) crewmember's pre- and postflight (at six and 21 days after landing) physical performance from a six-month mission to ISS are described...
January 2017: Musculoskelet Sci Pract
https://www.readbyqxmd.com/read/28171701/micrornas-key-players-in-host-parasite-interactions
#14
C Britton
The discovery of the RNA interference (RNAi) gene-silencing pathway in 1998 revolutionized analysis of gene function (1). In a similar way, the identification of another class of small RNAs, microRNAs (miRNAs), has significantly impacted our understanding of how genes are regulated in response to developmental, metabolic and environmental changes. The first miRNA, lin-4, was identified in the free-living nematode Caenorhabditis elegans in 1993 (2), but it was not until the discovery of the highly conserved let-7 miRNA in C...
February 7, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28162982/revival-of-old-antibiotics-needs-the-state-of-evidence-and-expectations
#15
Hiba Zayyad, Noa Eliakim-Raz, Leonard Leibovici, Mical Paul
The gap between the emergence of antibiotic resistance and new antibiotic development has drawn attention to old antibiotics whose spectrum of coverage frequently comprises highly resistant bacteria. However, these antibiotics have frequently not undergone the structured process of antibiotic development of modern antibiotics, from pharmacokinetic/pharmacodynamic (PK/PD) studies establishing safe and effective dosing, establishment of susceptibility breakpoints, to clinical trials establishing clinical safety and effectiveness...
February 2, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28159895/plant-cell-wall-signalling-and-receptor-like-kinases
#16
REVIEW
Sebastian Wolf
Communication between the extracellular matrix and the cell interior is essential for all organisms as intrinsic and extrinsic cues have to be integrated to co-ordinate development, growth, and behaviour. This applies in particular to plants, the growth and shape of which is governed by deposition and remodelling of the cell wall, a rigid, yet dynamic, extracellular network. It is thus generally assumed that cell wall surveillance pathways exist to monitor the state of the wall and, if needed, elicit compensatory responses such as altered expression of cell wall remodelling and biosynthesis genes...
February 15, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28154188/a-unique-structural-domain-in-methanococcoides-burtonii-rubisco-acts-as-a-small-subunit-mimic
#17
Laura H Gunn, Karin Valegård, Inger Andersson
The catalytic inefficiencies of the CO2-fixing enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) often limit plant productivity. Strategies to engineer more efficient plant Rubiscos have been hampered by evolutionary constraints, prompting interest in Rubisco isoforms from non-photosynthetic organisms. The methanogenic archaeon Methanococcoides burtonii contains a Rubisco isoform that functions to scavenge the ribulose-1,5-bisphosphate (RuBP) byproduct of purine/pyrimidine metabolism. The crystal structure of M...
January 30, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28153853/epigenetic-activation-of-mu-opioid-receptor-mor-gene-via-increased-expression-and-function-of-mitogen-and-stress-activated-protein-kinase-1-msk1
#18
Yadav Wagley, Ping-Yee Law, Li-Na Wei, Horace H Loh
Since the discovery of mu opioid receptor (MOR) gene two decades ago, various regulatory factors have been shown to interact with the MOR promoter and modulate transcript levels. However, the majority of early transcriptional studies on MOR gene have not addressed how intracellular signaling pathways mediate extracellular modulators. In this study, we demonstrate that MOR epigenetic regulation requires multiple co-ordinated signals converged at the MOR promoter, involving mitogen-activated protein kinase (MAPK) activation and mitogen-and stress-activated protein kinase (MSK1) - similar ranges of intracellular signaling pathways that are activated by opioid agonists...
February 2, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28153659/enoxaparin-for-the-prevention-of-preeclampsia-and%C3%A2-intrauterine-growth-restriction-in-women-with%C3%A2-a%C3%A2-history-%C3%A2-a%C3%A2-randomized-trial
#19
Katie M Groom, Lesley M McCowan, Laura K Mackay, Arier C Lee, Joanne M Said, Stefan C Kane, Susan P Walker, Thijs E van Mens, Natalie J Hannan, Stephen Tong, Larry W Chamley, Peter R Stone, Claire McLintock
BACKGROUND: Preeclampsia and small-for-gestational-age pregnancy are major causes of maternal and perinatal morbidity and mortality. Women with a previous pregnancy affected by these conditions are at an increased risk of recurrence in a future pregnancy. Past trials evaluating the effect of low-molecular-weight heparin for the prevention of recurrence of preeclampsia and small-for-gestational-age pregnancy have shown conflicting results with high levels of heterogeneity displayed when trials were compared...
January 30, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28152681/bringing-provincial-improvements-to-oral-chemotherapy-prescribing-through-co-ordinated-regional-initiatives
#20
Noor Ahmad, Leonard Kaizer, Erin Redwood, Kathy Vu, Colleen Fox, Elaine Meertens, Monika K Krzyzanowska
: 107 Background: Oral chemotherapy delivery is complex, making safe medication practices a high priority. Cancer Care Ontario, the provincial government agency responsible for continually improving cancer services in Ontario, undertook a jurisdiction-wide quality improvement initiative to ensure that all oral chemotherapy drugs are prescribed using Computerized Prescriber Order Entry (CPOE) or standardized Pre-printed Orders (PPO). The initiative was further enabled by changes to the provincial funding approach that flows facility funding for oral chemotherapy delivery...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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