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https://www.readbyqxmd.com/read/28630756/fast-track-in-hip-arthroplasty
#1
Torben Bæk Hansen
'Fast-track' surgery was introduced more than 20 years ago and may be defined as a co-ordinated peri-operative approach aimed at reducing surgical stress and facilitating post-operative recovery.The fast-track programmes have now been introduced into total hip arthroplasty (THA) surgery with reduction in post-operative length of stay, shorter convalescence and rapid functional recovery without increased morbidity and mortality. This has been achieved by focusing on a multidisciplinary collaboration and establishing 'fast-track' units, with a well-defined organisational set-up tailored to deliver an accelerated peri-operative course of fast-track surgical THA procedures...
May 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28630415/integrating-genome-and-transcriptome-profiling-for-elucidating-the-mechanism-of-muscle-growth-and-lipid-deposition-in-pekin-ducks
#2
Liyuan Wang, Xiangxiang Li, Jun Ma, Yawen Zhang, Hao Zhang
Muscle growth and lipid deposition are co-ordinately regulated processes. Cherry Valley Pekin duck is a lean-type duck breed with high growth rate, whereas the native Pekin duck of China has high lipid deposition. Phenotypic analysis showed that native Pekin ducks have smaller fibre diameter and larger density in the breast muscle at 3 weeks of age and higher intramuscular fat content at 6 weeks of age than those in Cherry Valley Pekin ducks. We detected 17 positively selected genes (PSGs) by comparing genes mainly involved with muscle organ development, muscle contraction, peroxisome proliferator activated receptor signalling pathway, and fatty acid metabolism...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28627136/enhancer-of-rudimentary-homologue-interacts-with-scaffold-attachment-factor-b-at-the-nuclear-matrix-to-regulate-sr-protein-phosphorylation
#3
Sotiria Drakouli, Aggeliki Lyberopoulou, Maria Papathanassiou, Ilias Mylonis, Eleni Georgatsou
Scaffold Attachment Factor B1 (SAFB1) is an integral component of the nuclear matrix of vertebrate cells.It binds to DNA on scaffold/matrix attachment region (S/MAR) elements, to RNA, and to a multitude of different proteins, affecting, as has been extensively substantiated, basic cellular activities such as transcription, splicing and DNA damage repair (DDR). In this study, we show that Enhancer of Rudimentary Homologue (ERH) is a new molecular partner of SAFB1 and its 70% homologous paralogue, Scaffold Attachment Factor B2 (SAFB2)...
June 19, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28627076/supportive-housing-for-chronically-homeless-individuals-challenges-and-opportunities-for-providers-in-chicago-usa
#4
Katherine Quinn, Julia Dickson-Gomez, Kelly Nowicki, Amy K Johnson, Arturo V Bendixen
Chronically homeless individuals often have extensive health, mental health and psychosocial needs that pose barriers to obtaining and maintain supportive housing. This study aims to qualitatively explore supportive housing providers' experiences and challenges with housing chronically homeless individuals and examine opportunities to improve supportive housing systems of care. In 2014, we conducted qualitative in-depth interviews with 65 programme administrators and case managers of supportive housing programmes in Chicago, IL...
June 18, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/28622488/dizziness-unsteadiness-visual-disturbances-and-sensorimotor-control-in-traumatic-neck-pain
#5
Julia Treleaven
Synopsis There is considerable evidence to support the importance of cervical afferent dysfunction in the development of dizziness, unsteadiness, visual disturbances and altered balance, eye, and head movement control following neck trauma, especially in those with persistent symptoms. However, there are other possible causes for these symptoms and secondary adaptive changes should also be considered in the process of differential diagnosis. Understanding the nature of these symptoms and the differential diagnosis of their potential origin is important for rehabilitation...
June 16, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28619310/dance-for-parkinson-s-the-effects-on-whole-body-co-ordination-during-turning-around
#6
Sophia Hulbert, Ann Ashburn, Lisa Roberts, Geert Verheyden
OBJECTIVE: To investigate the effects of ballroom and Latin American dancing classes on turning in people with Parkinson's. DESIGN: This study employed a randomised, controlled, experimental design. SETTING: Dance classes were performed in a community dance centre in Southern England and all assessments took place a gait laboratory. PARTICIPANTS: Twenty-seven people with mild-moderate Parkinson's participated. INTERVENTION: Participants were randomly allocated to receive either 20, 1-h dancing classes over 10 weeks (n=15), or a 'usual care' control group (n=12)...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28616191/towards-the-co-ordination-of-terrestrial-ecosystem-protocols-across-european-research-infrastructures
#7
Les G Firbank, Chiara Bertora, David Blankman, Gemini Delle Vedove, Mark Frenzel, Carlo Grignani, Elli Groner, Miklós Kertész, Eveline J Krab, Giorgio Matteucci, Christina Menta, Carsten W Mueller, Jutta Stadler, William E Kunin
The study of ecosystem processes over multiple scales of space and time is often best achieved using comparable data from multiple sites. Yet, long-term ecological observatories have often developed their own data collection protocols. Here, we address this problem by proposing a set of ecological protocols suitable for widespread adoption by the ecological community. Scientists from the European ecological research community prioritized terrestrial ecosystem parameters that could benefit from a more consistent approach to data collection within the resources available at most long-term ecological observatories...
June 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28603881/early-palliative-care-for-adults-with-advanced-cancer
#8
REVIEW
Markus W Haun, Stephanie Estel, Gerta Rücker, Hans-Christoph Friederich, Matthias Villalobos, Michael Thomas, Mechthild Hartmann
BACKGROUND: Incurable cancer, which often constitutes an enormous challenge for patients, their families, and medical professionals, profoundly affects the patient's physical and psychosocial well-being. In standard cancer care, palliative measures generally are initiated when it is evident that disease-modifying treatments have been unsuccessful, no treatments can be offered, or death is anticipated. In contrast, early palliative care is initiated much earlier in the disease trajectory and closer to the diagnosis of incurable cancer...
June 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28603550/health-system-governance-to-support-scale-up-of-mental-health-care-in-ethiopia-a-qualitative-study
#9
Charlotte Hanlon, Tigist Eshetu, Daniel Alemayehu, Abebaw Fekadu, Maya Semrau, Graham Thornicroft, Fred Kigozi, Debra Leigh Marais, Inge Petersen, Atalay Alem
BACKGROUND: Ethiopia is embarking upon a ground-breaking plan to address the high levels of unmet need for mental health care by scaling up mental health care integrated within primary care. Health system governance is expected to impact critically upon the success or otherwise of this important initiative. The objective of the study was to explore the barriers, facilitators and potential strategies to promote good health system governance in relation to scale-up of mental health care in Ethiopia...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/28600851/neonatal-surgery-in-a-developing-country-outcome-of-co-ordinated-interdisciplinary-collaboration
#10
Sebastian O Ekenze, Victor O Modekwe, Obinna V Ajuzieogu, Isaac O Asinobi, Jubril Sanusi
AIM: Neonatal surgery in low-income and middle-income countries has a poorer outcome when compared with high-income countries. This study evaluated the management challenges and outcomes of neonatal surgery before and after the introduction of focused interdisciplinary team management in 2013. METHODS: We retrospectively analysed neonatal surgery undertaken at two referral hospitals in Enugu, south-eastern Nigeria from January 2011 to November 2015. Cases managed prior to July 2013 (group A) were compared with those managed from July 2013 (group B)...
June 10, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28599632/alcohol-screening-and-brief-interventions-for-adults-and-young-people-in-health-and-community-based-settings-a-qualitative-systematic-literature-review
#11
Jane Derges, Judi Kidger, Fiona Fox, Rona Campbell, Eileen Kaner, Matthew Hickman
BACKGROUND: Systematic reviews of alcohol screening and brief interventions (ASBI) highlight the challenges of implementation in healthcare and community-based settings. Fewer reviews have explored this through examination of qualitative literature and fewer still focus on interventions with younger people. METHODS: This review aims to examine qualitative literature on the facilitators and barriers to implementation of ASBI both for adults and young people in healthcare and community-based settings...
June 9, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28599534/on-the-scattering-of-torsional-waves-from-axisymmetric-defects-in-buried-pipelines
#12
Wenbo Duan, Ray Kirby, Peter Mudge
This article develops a numerical model suitable for analysing elastic wave scattering in buried pipelines. The model is based on a previous so-called hybrid approach, where a nominally infinite length of pipe is split up into uniform and non-uniform regions. The key challenge for buried structures is in enforcing the appropriate boundary conditions in both the axial and radial directions, which must encompass the entire length of the structure, as well as the surrounding material. Accordingly, the focus of this article is on developing a model suitable for accurately applying these boundary conditions, and so the analysis is restricted here to the study of axisymmetric defects and to an incident sound field that consists of the fundamental torsional mode only...
May 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28591665/inhibition-of-pseudomonas-aeruginosa-quorum-sensing-by-subinhibitory-concentrations-of-curcumin-with-gentamicin-and-azithromycin
#13
Shahin Bahari, Habib Zeighami, Hesam Mirshahabi, Shekoufeh Roudashti, Fakhri Haghi
OBJECTIVES: Pseudomonas aeruginosa quorum sensing (QS) circuits regulate virulence factors and co-ordinate bacterial pathogenicity. This study aimed to investigate the inhibitory activity of subinhibitory concentrations of curcumin with azithromycin and gentamicin against P. aeruginosa QS-related genes and virulence factors. METHODS: The minimum inhibitory concentrations (MICs) and synergistic activity of curcumin with azithromycin and gentamicin against P. aeruginosa PAO1 were determined using broth microdilution and checkerboard titration methods, respectively...
June 4, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28589563/bop2-bayesian-optimal-design-for-phase-ii-clinical-trials-with-simple-and-complex-endpoints
#14
Heng Zhou, J Jack Lee, Ying Yuan
We propose a flexible Bayesian optimal phase II (BOP2) design that is capable of handling simple (e.g., binary) and complicated (e.g., ordinal, nested, and co-primary) endpoints under a unified framework. We use a Dirichlet-multinomial model to accommodate different types of endpoints. At each interim, the go/no-go decision is made by evaluating a set of posterior probabilities of the events of interest, which is optimized to maximize power or minimize the number of patients under the null hypothesis. Unlike other existing Bayesian designs, the BOP2 design explicitly controls the type I error rate, thereby bridging the gap between Bayesian designs and frequentist designs...
June 7, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28575760/benign-childhood-epilepsy-with-centrotemporal-spikes-bects-and-developmental-co-ordination-disorder
#15
Amanda Kirby, Natalie Williams, Loes Koelewijn, Lisa M Brindley, Suresh D Muthukumaraswamy, Johann Te Water Naudé, Marie Thomas, Frances Gibbon, Krish D Singh, Khalid Hamandi
BACKGROUND: Benign epilepsy with centro-temporal spikes (BECTS) is a common childhood epilepsy syndrome also known as Rolandic Epilepsy (RE). Neurocognitive phenotypes have been described with greater focus on attention, reading and language domains but there have been far fewer studies focusing on motor functioning. This study included measures of motor, language and cognition in order to investigate the range, degree and pattern of difficulties associated with BECTS in a case series of children, but with a particular emphasis on motor skills...
May 30, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28573736/epilepsy-as-a-systemic-condition-link-with-somatic-comorbidities
#16
J Novy, G S Bell, J L Peacock, S M Sisodiya, J W Sander
BACKGROUND: People with epilepsy have more concomitant medical conditions than the general population; these comorbidities play an important role in premature mortality. We sought to generate explanatory hypotheses about the co-occurrence of somatic comorbidities and epilepsy, avoiding causal and treatment-resultant biases. METHODS: We collected clinical, demographic and somatic comorbidity data for 2016 consecutive adults with epilepsy undergoing assessment at a tertiary centre and in 1278 people with epilepsy in the community...
June 1, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28572540/analysis-of-region-specific-gene-expression-patterns-in-the-heart-and-systemic-responses-after-experimental-myocardial-ischemia
#17
Matthias Zimmermann, Lucian Beer, Robert Ullrich, Dominika Lukovic, Elisabeth Simader, Denise Traxler, Tanja Wagner, Lucas Nemec, Lukas Altenburger, Andreas Zuckermann, Mariann Gyöngyösi, Hendrik Jan Ankersmit, Michael Mildner
AIMS: Ischemic myocardial injury leads to the activation of inflammatory mechanisms and results in ventricular remodeling. Although great efforts have been made to unravel the molecular and cellular processes taking place in the ischemic myocardium, little is known about the effects on the surrounding tissue and other organs. The aim of this study was to determine region specific differences in the myocardium and in distant organs after experimental myocardial infarction by using a bioinformatics approach...
May 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28569414/bsa-aunps-tb-amp-metal-organic-frameworks-for-ratiometric-fluorescence-detection-of-dpa-and-hg-2
#18
Keying Cai, Mulan Zeng, Fenfen Liu, Nan Liu, Zhenzhong Huang, Yonghai Song, Li Wang
An easy and effective strategy for synthesizing a ratiometric fluorescent nanosensor has been demonstrated in this work. Novel fluorescent BSA-AuNPs@Tb-AMP (BSA, bovine serum albumin; AMP, adenosine 5'-monophosphate; AuNPs, Au nanoparticles) metal-organic framework (MOF) nanostructures were synthesized by encapsulating BSA-AuNPs into Tb-AMP MOFs for the detection of 2,6-pyridinedicarboxylic acid (DPA) and Hg(2+) . DPA could strongly co-ordinate with Tb(3+) to replace water molecules from the Tb(3+) center and accordingly enhanced the fluorescence of Tb-AMP MOFs...
June 1, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28569397/promoting-continuity-of-care-for-homeless-adults-with-unmet-health-needs-the-role-of-brief-interventions
#19
Denise Lamanna, Vicky Stergiopoulos, Janet Durbin, Patricia O'Campo, Daniel Poremski, Joshua Tepper
Promoting timely and continuous care for people experiencing homelessness has been a challenge in many jurisdictions, plagued by access barriers and service fragmentation. As part of a larger programme evaluation, this study used qualitative methods to examine the role of a brief interdisciplinary intervention in supporting continuity of care for this population in a large Canadian urban centre. The intervention provides time-limited case management, primary and psychiatric care, and peer accompaniment to homeless adults with unmet health needs discharged from hospital...
June 1, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/28565932/information-transfer-capacity-of-articulators-in-american-sign-language
#20
Evie Malaia, Joshua D Borneman, Ronnie B Wilbur
The ability to convey information is a fundamental property of communicative signals. For sign languages, which are overtly produced with multiple, completely visible articulators, the question arises as to how the various channels co-ordinate and interact with each other. We analyze motion capture data of American Sign Language (ASL) narratives, and show that the capacity of information throughput, mathematically defined, is highest on the dominant hand (DH). We further demonstrate that information transfer capacity is also significant for the non-dominant hand (NDH), and the head channel too, as compared to control channels (ankles)...
May 1, 2017: Language and Speech
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