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https://www.readbyqxmd.com/read/28651154/new-comprehensive-studies-of-a-gold-iii-dithiocarbamate-complex-with-proven-anticancer-properties-aqueous-dissolution-with-cyclodextrins-pharmacokinetics-and-upstream-inhibition-of-the-ubiquitin-proteasome-pathway
#1
Marianna F Tomasello, Chiara Nardon, Valeria Lanza, Giuseppe Di Natale, Nicolò Pettenuzzo, Stefano Salmaso, Danilo Milardi, Paolo Caliceti, Giuseppe Pappalardo, Dolores Fregona
The gold(III)-dithiocarbamate complex AuL12 (dibromo [ethyl-N-(dithiocarboxy-kS,kS')-N-methylglycinate] gold(III)), is endowed with promising in vitro/in vivo antitumor activity and toxicological profile. Here, we report our recent strategies to improve its water solubility and stability under physiological conditions along with our efforts for unravelling its tangled mechanism of action. We used three types of α-cyclodextrins (CDs), namely β-CD, Me-β-CD and HP-β-CD to prepare aqueous solutions of AuL12...
June 19, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28650690/coordinated-expression-of-acrab-tolc-and-eight-other-functional-efflux-pumps-through-activating-rama-and-mara-in-salmonella-enterica-serovar-typhimurium
#2
Chuan-Zhen Zhang, Pin-Xian Chen, Lei Yang, Wan Li, Man-Xia Chang, Hong-Xia Jiang
The aim of this study was to determine the expression of eight other functional transporter genes upon acrAB inactivation and also the expression of acrAB when the function of eight other transporters are impaired in Salmonella enterica. We used single- or multigene deletion mutants (i.e., ΔacrA, ΔacrB, ΔtolC, ΔacrAB, ΔacrEF, ΔacrD, ΔmdsABC, ΔmdtABC, ΔemrAB, ΔmacAB, ΔmdfA, ΔmdtK, ΔacrABramA, ΔacrABmarA, and ΔacrABsoxS) and real time (RT)-PCR to quantify the expression of different pump and regulator genes; infection ability was characterized by adhesion and invasion assays...
June 26, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28650620/influence-of-the-disposition-of-the-anisotropy-axes-into-the-magnetic-properties-of-mn-iii-dinuclear-compounds-with-benzoato-derivative-bridges
#3
Beltzane Garcia-Cirera, Silvia Gómez-Coca, Mercè Font-Bardia, Eliseo Ruiz, Montserrat Corbella
The two new Mn(III) dinuclear compounds [{Mn(H2O)(phen)}2(μ-4-CH3C6H4COO)2(μ-O)](ClO4)2·3CH3CN·H2O (1·3CH3CN·H2O) and [{Mn(H2O)(phen)}(μ-O)(μ-2-BrC6H4COO)2{Mn(NO3)(phen)}]NO3 (2) have been synthesized. Their structural data reveal significant differences in the shape of the coordination octahedron around the Mn(III) ions in both compounds. The different distortions from ideal geometry incite a very different magnetic behavior, affecting both the zero-field splitting parameters of the Mn(III) ions (DMn and EMn) and the magnetic interaction between them...
June 26, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28650571/development-of-proton-responsive-catalysts
#4
REVIEW
Lin Wang, Ryoichi Kanega, Hajime Kawanami, Yuichiro Himeda
A changeable ligand, which involves in activation of a catalyst or assists a reaction, draws an increasing attention, in contrast to a classical ligand as spectator. Proton-responsive catalysts, which are capable of undergoing changes of properties on gaining/losing one or more protons, provides interesting features as follows: (i) catalyst activation by electronic effect, (ii) pH-tuning of water-solubility, and (iii) second-coordination-sphere interaction. On the basis of this catalyst design concept, we developed several highly efficient proton-responsive catalysts for CO2 hydrogenation as H2 storage, formic acid (FA) dehydrogenation as H2 production, and transfer hydrogenation...
June 26, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28650511/effect-of-mixed-anions-on-the-physicochemical-properties-of-a-sodium-containing-alkoxyammonium-ionic-liquid-electrolyte
#5
Matthias Hilder, Matthieu Gras, Cameron R Pope, Mega Kar, Douglas R MacFarlane, Maria Forsyth, Luke A O'Dell
The physicochemical properties of the ionic liquid N-ethyl-2-(2-methoxyethoxy)-N,N-bis(2-(2-methoxyethoxy)ethyl)ethan-1-ammonium bis(trifluoromethylsulfonyl)imide (N2(2O2O1)3TFSI) as well as its solutions with sodium bis(trifluoromethylsulfonyl)imide (NaTFSI) and sodium bis(fluorosulfonyl)imide (NaFSI) are compared in order to study the effects of the anion. The NaFSI solutions show weaker interactions as suggested by lower glass transition temperatures, lower densities, lower viscosities and higher conductivities as compared to their more strongly coordinating NaTFSI analogues...
June 26, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28650498/two-step-fret-mediated-metal-ion-induced-signalling-responses-in-a-probe-appended-with-three-fluorophores
#6
Biswonath Biswal, Ajoy Pal, Bamaprasad Bag
A tri-fluorophoric molecular probe (1) with three different derivatized fluorophores, i.e. anthracene (An), 7-nitrobenz-2-oxa-1,3-diazole (NBD) and rhodamine-B (Rh) appended on to a Tren [tris-(2-aminoethyl)amine] receptor was demonstrated to exhibit metal ion induced ratiometric fluorescence signalling through the initiation of a two-step fluorescence resonance energy transfer (FRET) process owing to a compatible and substantial spectral overlap of electronic absorption and fluorescence of initial donor-intermediate donor/acceptor-final acceptor pairs...
June 26, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28650492/exploiting-the-biosynthetic-machinery-of-streptomyces-pilosus-to-engineer-a-water-soluble-zirconium-iv-chelator
#7
Tomas Richardson-Sanchez, William Tieu, Michael P Gotsbacher, Thomas J Telfer, Rachel Codd
The water solubility of a natural product-inspired octadentate hydroxamic acid chelator designed to coordinate Zr(iv)-89 has been improved by using a combined microbiological-chemical approach to engineer four ether oxygen atoms into the main-chain region of a methylene-containing analogue. First, an analogue of the trimeric hydroxamic acid desferrioxamine B (DFOB) that contained three main-chain ether oxygen atoms (DFOB-O3) was generated from cultures of the native DFOB-producer Streptomyces pilosus supplemented with oxybis(ethanamine) (OBEA), which competed against the native 1,5-diaminopentane (DP) substrate during DFOB assembly...
June 26, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28650476/cry2h-seq-a-massively-multiplexed-assay-for-deep-coverage-interactome-mapping
#8
Shelly A Trigg, Renee M Garza, Andrew MacWilliams, Joseph R Nery, Anna Bartlett, Rosa Castanon, Adeline Goubil, Joseph Feeney, Ronan O'Malley, Shao-Shan C Huang, Zhuzhu Z Zhang, Mary Galli, Joseph R Ecker
Broad-scale protein-protein interaction mapping is a major challenge given the cost, time, and sensitivity constraints of existing technologies. Here, we present a massively multiplexed yeast two-hybrid method, CrY2H-seq, which uses a Cre recombinase interaction reporter to intracellularly fuse the coding sequences of two interacting proteins and next-generation DNA sequencing to identify these interactions en masse. We applied CrY2H-seq to investigate sparsely annotated Arabidopsis thaliana transcription factors interactions...
June 26, 2017: Nature Methods
https://www.readbyqxmd.com/read/28650433/the-evening-complex-coordinates-environmental-and-endogenous-signals-in-arabidopsis
#9
Daphne Ezer, Jae-Hoon Jung, Hui Lan, Surojit Biswas, Laura Gregoire, Mathew S Box, Varodom Charoensawan, Sandra Cortijo, Xuelei Lai, Dorothee Stöckle, Chloe Zubieta, Katja E Jaeger, Philip A Wigge
Plants maximize their fitness by adjusting their growth and development in response to signals such as light and temperature. The circadian clock provides a mechanism for plants to anticipate events such as sunrise and adjust their transcriptional programmes. However, the underlying mechanisms by which plants coordinate environmental signals with endogenous pathways are not fully understood. Using RNA-sequencing and chromatin immunoprecipitation sequencing experiments, we show that the evening complex (EC) of the circadian clock plays a major role in directly coordinating the expression of hundreds of key regulators of photosynthesis, the circadian clock, phytohormone signalling, growth and response to the environment...
June 26, 2017: Nature Plants
https://www.readbyqxmd.com/read/28650429/acetate-mediated-novel-survival-strategy-against-drought-in-plants
#10
Jong-Myong Kim, Taiko Kim To, Akihiro Matsui, Keitaro Tanoi, Natsuko I Kobayashi, Fumio Matsuda, Yoshiki Habu, Daisuke Ogawa, Takuya Sakamoto, Sachihiro Matsunaga, Khurram Bashir, Sultana Rasheed, Marina Ando, Hiroko Takeda, Kanako Kawaura, Miyako Kusano, Atsushi Fukushima, Takaho A Endo, Takashi Kuromori, Junko Ishida, Taeko Morosawa, Maho Tanaka, Chieko Torii, Yumiko Takebayashi, Hitoshi Sakakibara, Yasunari Ogihara, Kazuki Saito, Kazuo Shinozaki, Alessandra Devoto, Motoaki Seki
Water deficit caused by global climate changes seriously endangers the survival of organisms and crop productivity, and increases environmental deterioration(1,2). Plants' resistance to drought involves global reprogramming of transcription, cellular metabolism, hormone signalling and chromatin modification(3-8). However, how these regulatory responses are coordinated via the various pathways, and the underlying mechanisms, are largely unknown. Herein, we report an essential drought-responsive network in which plants trigger a dynamic metabolic flux conversion from glycolysis into acetate synthesis to stimulate the jasmonate (JA) signalling pathway to confer drought tolerance...
June 26, 2017: Nature Plants
https://www.readbyqxmd.com/read/28650346/real-time-monitoring-through-the-use-of-technology-to-enhance-performances-throughout-hiv-cascades
#11
Matthew Avery, Stephen J Mills, Eric Stephan
PURPOSE OF REVIEW: Controlling the HIV epidemic requires strong linkages across a 'cascade' of prevention, testing, and treatment services. Information and communications technology (ICT) offers the potential to monitor and improve the performance of this HIV cascade in real time. We assessed recent (<18 months) peer-reviewed publications regarding uses of ICT to improve performance through expanded and targeted reach, improved clinical service delivery, and reduced loss to follow-up...
June 23, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28650255/patient-navigation-for-traumatic-brain-injury-promotes-community-re-integration-and-reduces-re-hospitalizations
#12
Emily R Rosario, Laura Espinoza, Stephanie Kaplan, Sepehr Khonsari, Earl Thurndyke, Melissa Bustos, Kayla Vickers, Brittney Navarro, Bonnie Scudder
OBJECTIVE: To determine the effectiveness of a Navigation programme for patients with traumatic brain injury. DESIGN: Prospective programme evaluation. SETTING: Inpatient rehabilitation facility and community settings. PARTICIPANTS: Eighteen individuals who suffered a traumatic brain injury (TBI), were between the ages of 16-70 years, and had a Rancho Score greater than IV. INTERVENTION: Patient navigation programme focused on identifying and addressing barriers to positive outcomes, including coordination of care and facilitating communication among the family and healthcare providers, psychosocial support, caregiver support, adherence to treatment, education, community resources and financial issues...
June 26, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28650251/managed-care-peer-led-teaching-an-innovative-learning-approach-outside-the-college-of-pharmacy-core-curriculum
#13
SyHui Tang, Julia Smith, Wilson Lau, Isaac Tse, Christine Tan, Ryan Cotten, Amy Pittenger
BACKGROUND: Managed care pharmacy is a growing field, but there are still limited educational opportunities available in pharmacy school core curricula. Students often seek self-directed learning opportunities to further explore the field. OBJECTIVES: To (a) evaluate practicality and effectiveness of a student-designed managed care pharmacy elective and (b) determine emerging best practices for design and sustainability of peer-led, self-directed courses. METHODS: A managed care elective course was designed as a student, peer-led course during the 2012-2013 school year at the University of Minnesota College of Pharmacy...
July 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28650217/a-new-outlook-on-sporadic-flowering-of-bamboo
#14
Rico Gamuyao, Keisuke Nagai, Motoyuki Ashikari, Stefan Reuscher
Moso bamboo (Phyllostachys edulis) is a temperate grass species with a tree-like habitus and an unusual reproduction strategy. While flowering is irregular and infrequent, new clonal bamboo shoots are established from an underground rhizome network during the spring season. In our previous study, we performed transcriptome analyses using bamboo shoot buds to understand the initiation of bamboo stem elongation. Interestingly, the expression profile in the shoot apical meristem (SAM) region of young bamboo shoots is similar to that of other plants...
June 26, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28650140/dual-physically-crosslinked-nanocomposite-hydrogels-reinforced-by-tunicate-cellulose-nanocrystals-with-high-toughness-and-good-self-recoverability
#15
Tiantian Zhang, Tao Zuo, Danning Hu, Chunyu Chang
The weak mechanical properties of hydrogels usually limited their application in biomedical and industrial fields. Herein, we reported a nanocomposite network of poly (acrylic acid-co-acrylamide) (PAAAM) sequentially crosslinked by quaternized tunicate cellulose nanocrystals (Q-TCNCs) and Fe3+. Q-TCNCs acted as both interfacial compatible reinforcements and cross-linkers in the nanocomposite hydrogels to form loose crosslinking, whereas compact crosslinking was built by ionic coordination between Fe3+ and -COO- of PAAAM...
June 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28650081/diastereoselective-self-assembly-of-a-neutral-dinuclear-double-stranded-zinc-ii-helicate-via-narcissistic-self-sorting
#16
Andreas Jarzebski, Christina Tenten, Christoph Bannwarth, Gregor Schnakenburg, Stefan Grimme, Arne Lützen
A new bis(salicylimine) ligand based on the Tröger's base scaffold was synthesized in racemic and enantiomerically pure form. Upon coordination to zinc(II) ions this ligand undergoes highly diastereoselective self-assembly into neutral dinuclear double-stranded helicates as proven by XRD analysis and via comparison of experimental ECD-spectra with those simulated with quantum chemical methods. When the racemic ligand was used self-assembly occurs under narcissistic self-sorting resulting in the formation of a racemic pair of helicates as revealed by NMR spectroscopy and XRD analysis...
June 26, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28650077/considerations-on-the-assessment-of-developmental-coordination-disorder-and-the-elaboration-of-related-contextual-pathways
#17
Matthias Wagner
No abstract text is available yet for this article.
June 26, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28650056/tailoring-the-local-environment-around-metal-ions-a-solution-chemical-and-structural-study-of-some-multidentate-tripodal-ligands
#18
Ferenc Matyuska, Attila Szorcsik, Nóra V May, Ágnes Dancs, Éva Kováts, Attila Bényei, Tamás Gajda
Manganese(ii), copper(ii) and zinc(ii) complexes of four polydentate tripodal ligands (tachpyr (N,N',N''-tris(2-pyridylmethyl)-cis,cis-1,3,5-triaminocyclohexane), trenpyr (tris[2-(2-pyridylmethyl)aminoethyl]amine, tach3pyr (N,N',N''-tris(3-pyridylmethyl)-cis,cis-1,3,5-triaminocyclohexane) and tren3pyr (tris[2-(2-pyridylmethyl)aminoethyl]amine)) were characterized in both solution and solid states. A combined evaluation of potentiometric, UV-VIS, NMR and EPR data allowed the conclusion of both thermodynamic and structural information about the complexes formed in solution...
June 26, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28650049/lanthanide-doped-coordination-polymers-with-tunable-afterglow-based-on-phosphorescence-energy-transfer
#19
Yongsheng Yang, Ke-Zhi Wang, Dongpeng Yan
Lanthanide ion doped coordination polymers (CPs) exhibit an unusual red/green afterglow with long photoemission lifetimes (10.54 ms for Eu(3+) and 57.66 ms for Tb(3+)) due to the phosphorescence energy transfer at room temperature.
June 26, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28650035/sterically-encumbered-metalla-diphosphines-unlocking-alkyne-rotation-by-pt-ii-coordination
#20
Kai Helmdach, Stephan Dörk, Alexander Villinger, Wolfram W Seidel
We present the synthesis and coordination chemistry of a series of W(II) alkyne complexes with symmetric and asymmetric acetylene diphosphines. Chelate-like P,P'-coordination of PtCl2 cause a drastic potential change of the W centered oxidation proving intermetallic cooperativity. The choice of peripheric P-substituents has a measurable influence on the potential itself as well on the respective potential change upon coordination. The enlarged deviation of the diphosphino alkyne from linearity in the dinuclear complexes unlock alkyne rotation making different isomers accessible...
June 26, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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