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https://www.readbyqxmd.com/read/28538993/fefsem-neuronal-response-during-combined-volitional-and-reflexive-pursuit
#1
Leah Bakst, Jérome Fleuriet, Michael J Mustari
Although much is known about volitional and reflexive smooth eye movements individually, much less is known about how they are coordinated. It is hypothesized that separate cortico-ponto-cerebellar loops subserve these different types of smooth eye movements. Specifically, the MT-MST-DLPN pathway is thought to be critical for ocular following eye movements, whereas the FEF-NRTP pathway is understood to be vital for volitional smooth pursuit. However, the role that these loops play in combined volitional and reflexive behavior is unknown...
May 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28538918/mental-health-care-for-brazilian-juvenile-offenders
#2
Nilson do Rosário Costa, Paulo Roberto Fagundes da Silva
This paper analyzes the use of psychoactive drugs by juvenile offenders in Brazil in socio-educational facilities (USEs). It describes the guidelines of the national public policy and the quality of mental healthcare coordination by subnational public governments. This work draws on the hypothesis that USEs vertical governance is associated with the use of psychoactive medication. This is comparative study of two cases in Rio Grande do Sul and Minas Gerais. Data resulted from a sample of medical records and interviews with key informants...
May 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28538831/effects-of-laryngeal-manual-therapy-lmt-and-transcutaneous-electrical-nerve-stimulation-tens-in-vocal-folds-diadochokinesis-of-dysphonic-women-a-randomized-clinical-trial
#3
Larissa Thaís Donalonso Siqueira, Kelly Cristina Alves Silverio, Alcione Ghedini Brasolotto, Rinaldo Roberto de Jesus Guirro, Christiano Giácomo Carneiro, Mara Behlau
Purpose: To verify and compare the effect of transcutaneous electrical nerve stimulation (TENS) and laryngeal manual therapy (LMT) on laryngeal diadochokinesis (DDK) of dysphonic women. Methods: Twenty women with bilateral vocal nodules participated and were equally divided into: LMT Group - LMT application; TENS Group - TENS application; both groups received 12 sessions of treatment, twice a week, with a duration of 20 minutes each, applied by the same therapist...
May 15, 2017: CoDAS
https://www.readbyqxmd.com/read/28538724/applying-systems-level-spectral-imaging-and-analysis-to-reveal-the-organelle-interactome
#4
Alex M Valm, Sarah Cohen, Wesley R Legant, Justin Melunis, Uri Hershberg, Eric Wait, Andrew R Cohen, Michael W Davidson, Eric Betzig, Jennifer Lippincott-Schwartz
The organization of the eukaryotic cell into discrete membrane-bound organelles allows for the separation of incompatible biochemical processes, but the activities of these organelles must be coordinated. For example, lipid metabolism is distributed between the endoplasmic reticulum for lipid synthesis, lipid droplets for storage and transport, mitochondria and peroxisomes for β-oxidation, and lysosomes for lipid hydrolysis and recycling. It is increasingly recognized that organelle contacts have a vital role in diverse cellular functions...
May 24, 2017: Nature
https://www.readbyqxmd.com/read/28538660/regulatory-plasticity-of-earthworm-wmt-2-gene-expression
#5
Victoria Drechsel, Karl Schauer, Maja Šrut, Martina Höckner
Metallothioneins (MTs) are multifunctional proteins occurring throughout the animal kingdom. While the expression and transcriptional regulation of MTs is well-studied in vertebrates, the mechanism of MT activation is still unknown for most invertebrates. Therefore, we examined wMT-2 gene regulation and expression patterns in Lumbricus rubellus and L. terrestris. Transcription levels, the occupation of DNA binding sites, the expression of putative transcriptional regulators, and promotor DNA methylation were determined...
May 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28538626/the-capacity-of-icd-10-cm-pcs-to-characterize-surgical-care
#6
Garth H Utter, Kevin M Schuster, Preston R Miller, Nathan T Mowery, Suresh K Agarwal, Robert J Winchell, Marie L Crandall
The International Classification of Diseases, 10th edition, Clinical Modification and Procedure Coding System (ICD-10-CM/PCS) have been in effect since October 1, 2015 and offer much greater capacity than previous classifications to characterize the nature and treatment of surgical conditions. However, the diagnosis codes of ICD-10-CM are unevenly specific across the spectrum of surgical conditions and currently do not adequately allow description of important distinctions in disease severity for many common surgical conditions...
May 22, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28538596/acute-and-hyper-acute-thoracolumbar-corpectomy-for-traumatic-burst-fractures-using-a-mini-open-lateral-approach
#7
William D Smith, Nick Ghazarian, Ginger Christian
STUDY DESIGN: Retrospective chart review. OBJECTIVE: The study purpose was to examine the feasibility of acute (<24 hours) and hyper-acute (<8 hours) treatment of thoracolumbar burst fractures to maintain or improve spinal injury scores. SUMMARY OF BACKGROUND DATA: Historically, treatment of spinal burst fractures within 24 hours from injury was considered an "acute" treatment timeframe. Patient polytrauma triage, multiple surgical specialty and hospital resource coordination affect time to treatment...
May 22, 2017: Spine
https://www.readbyqxmd.com/read/28538310/enhancing-digital-video-analysis-of-bar-kinematics-in-weightlifting-a-case-study
#8
Torstein E Dæhlin, Tron Krosshaug, Loren Z F Chiu
Dæhlin, TE, Krosshaug, T, and Chiu, LZF. Enhancing digital video analysis of bar kinematics in weightlifting: a case study. J Strength Cond Res 31(6): 1592-1600, 2017-Weightlifting technique can be objectively assessed from two-dimensional video recordings. Despite its importance, participants' bar trajectories in research involving the snatch or clean exercises are often not reported, potentially due to the time required to digitize video. The purpose of this investigation was to evaluate the use of a light-emitting diode (LED)-based marker, digital video, and open-source software to automatically track the bar end during weightlifting exercises...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538298/quantifying-the-high-speed-running-and-sprinting-profiles-of-elite-female-soccer-players-during-competitive-matches-using-an-optical-player-tracking-system
#9
Jocelyn K Mara, Kevin G Thompson, Kate L Pumpa, Stuart Morgan
Mara, JK, Thompson, KG, Pumpa, KL, and Morgan, S. Quantifying the high-speed running and sprinting profiles of elite female soccer players during competitive matches using an optical player tracking system. J Strength Cond Res 31(6): 1500-1508, 2017-The aim of this study was to determine the high-speed running and sprinting profiles of elite female soccer players during competitive matches using a new Optical Player Tracking system. Eight stationary video cameras were positioned at vantage points surrounding the soccer field so that when each camera view was combined, the entire field could be viewed simultaneously...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538196/self-assembly-of-gd-3-sds-hepes-complex-and-curcumin-entrapment-for-enhanced-stability-fluorescence-image-in-cellular-system
#10
Chonticha Sahub, Gamolwan Tumcharern, Prae Chirawatkul, Vithaya Ruangpornvisuti, Sanong Ekgasit, Supasorn Wanichweacharungruang, Thawatchai Tuntulani, Tanapat Palaga, Boosayarat Tomapatanaget
At present, strategies to disperse hydrophobic molecules in water without altering their chemical structures include conventional surfactant-based micellar and vesicular systems, encapsulation into water dispersible polymeric nanoparticles, and loading onto the surface of various metal nanoparticles. Here, we report a simple and low cost platform to incorporate hydrophobic molecules into a stable water dispersible nanostructure that can significantly increase the stability of the encapsulated materials. The platform is based on the incorporation of hydrophobic molecules into the self-assembled complex of gadolinium ion (Gd(3+)), sodium dodecyl sulfate (SDS), and 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) called GdSH...
May 13, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28538165/the-complexity-in-herpesvirus-entry
#11
REVIEW
Karthik Sathiyamoorthy, Jia Chen, Richard Longnecker, Theodore S Jardetzky
Enveloped viruses have evolved diverse transmembrane proteins and protein complexes to enable host cell entry by regulating and activating membrane fusion in a target cell-specific manner. In general terms, the entry process requires a receptor binding step, an activation step and a membrane fusion step, which can be encoded within a single viral protein or distributed among multiple viral proteins. HIV and influenza virus, for example, encode all of these functions in a single trimeric glycoprotein, HIV env or influenza virus hemagglutinin (HA)...
May 21, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28538098/two-dimensional-metal-organic-framework-nanosheets-as-an-enzyme-inhibitor-modulation-of-the-%C3%AE-chymotrypsin-activity
#12
Ming Xu, Shuai Yuan, Xin-Yu Chen, Yu-Jie Chang, Gregory Steven Day, Zhi-Yuan Gu, Hong-Cai Zhou
Two-dimensional metal-organic framework (MOF) nanosheets are utilized as effective enzyme inhibitors, providing an in-spiring means to enhance the control of cellular processes as well as improve our understanding of the surface chemistry between MOFs and enzymes. In this paper, we demonstrated that the activity of α-Chymotrypsin (ChT) can be effectively inhibited with 96.9% inhibition by the 2-D Cu(bpy)2(OTf)2 nanosheets, while the other Zn2(bim)4 nanosheets show no significant inhibition effect towards ChT...
May 24, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28538045/donor-derived-infections-in-solid-organ-transplant-patients-toward-a-holistic-approach
#13
Esther Benamu, Cameron R Wolfe, Jose G Montoya
PURPOSE OF REVIEW: Solid organ demand far exceeds organ supply. Strategies to increase the donor pool include the liberalization of selection criteria without increasing the risk of unexpected donor-derived infection (DDI), a rare complication of transplantation carrying high morbidity and mortality. We review the challenging aspects in the prevention of DDI, focusing on the complexities of data sharing and efficient communication and the role infectious diseases specialists play in the process...
May 19, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28538028/unnecessary-cost-of-post-mohs-permanent-pathology
#14
Kelly M MacArthur, Nikki Tang, George J Hruza, Timothy S Wang, Robert G Egbers
BACKGROUND: By providing tumor-free margins, Mohs micrographic surgery (MMS) results in high cure rates in the treatment of nonmelanoma skin cancers (NMSCs). However, when closure of the post-MMS defect is coordinated with reconstructive surgery, redundant tissue is sometimes submitted for permanent section evaluation. OBJECTIVE: The purpose of our study was to investigate the frequency and effect of this practice. MATERIALS AND METHODS: Patients (12 years and older) with NMSCs cleared by MMS with coordinated closures from 2014 to 2016 were identified...
May 22, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28537964/the-impact-of-the-affordable-care-act-on-cancer-survivorship
#15
Christine Leopold, Elyse R Park, Larissa Nekhlyudov
In 2010, the Patient Protection and Affordable Care Act (ACA) was implemented with the aim of expanding access to quality, affordable care. In this review, we describe the ACA provisions that are most relevant for cancer survivors, provide available published evidence, and offer insights for future research. We found that provisions focusing on access to preventive care, access to quality and coordinated care, and coverage expansion and increased affordability suggest beneficial effects. However, we identified research gaps specifically addressing the intended and unintended consequences of the ACA on cancer survivorship care...
May 2017: Cancer Journal
https://www.readbyqxmd.com/read/28537961/the-affordable-care-act-and-cancer-care-delivery
#16
Gabriel A Brooks, J Russell Hoverman, Carrie H Colla
The Affordable Care Act (ACA) has reformed US health care delivery through insurance coverage expansion, experiments in payment design, and funding for patient-centered clinical and health care delivery research. The impact on cancer care specifically has been far reaching, with new ACA-related programs that encourage coordinated, patient-centered, cost-effective care. Insurance expansions through private exchanges and Medicaid, along with preexisting condition clauses, have helped more than 20 million Americans gain health care coverage...
May 2017: Cancer Journal
https://www.readbyqxmd.com/read/28537952/providing-coordinated-cancer-care-a-qualitative-study-of-norwegian-cancer-coordinators-experiences-of-their-role
#17
Nataskja-Elena Kersting Lie, May Aasebø Hauken, Per Koren Solvang
BACKGROUND: There is a growing need for strategies to improve coordinated, tailored services in cancer care to meet the comprehensive needs of cancer patients. In Norway, cancer coordinators (CCs) have been established to improve coordination and patient-centeredness of services. Little is known about how CCs engage to provide patients with the needed services and support throughout the treatment. OBJECTIVE: The aim of this study was to explore how Norwegian CCs experience their role and how they enact it in order to enhance coordinated cancer care...
May 23, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28537814/a-human-oriented-framework-for-developing-assistive-service-robots
#18
Conor McGinn, Michael F Cullinan, Mark Culleton, Kevin Kelly
PURPOSE: Multipurpose robots that can perform a range of useful tasks have the potential to increase the quality of life for many people living with disabilities. Owing to factors such as high system complexity, as-yet unresolved research questions and current technology limitations, there is a need for effective strategies to coordinate the development process. METHOD: Integrating established methodologies based on human-centred design and universal design, a framework was formulated to coordinate the robot design process over successive iterations of prototype development...
May 24, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28537729/stretching-induced-conductance-variations-as-fingerprints-of-contact-configurations-in-single-molecule-junctions
#19
Yong-Hoon Kim, Hu Sung Kim, Juho Lee, Makusu Tsutsui, Tomoji Kawai
Molecule-electrode contact atomic structures are a critical factor that characterizes molecular devices, but their precise understanding and control still remain elusive. Based on combined first-principles calculations and single-molecule break junction experiments, we herein establish that the conductance of alkanedithiolate junctions can both increase and decrease with mechanical stretching and the specific trend is determined by the S-Au linkage coordination number (CN) or the molecule-electrode contact atomic structure...
May 24, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28537709/titanium-oxo-cluster-with-six-peripheral-ferrocene-units-and-its-photocurrent-response-properties-for-saccharides
#20
Jin-Le Hou, Wen Luo, Yao Guo, Ping Zhang, Shen Yang, Qin-Yu Zhu, Jie Dai
A unique titanium oxo cluster with a ferrocene ligand was synthesized and characterized by single crystal X-ray analysis. Six ferrocene carboxylates coordinate to a D3d Ti6O6 core to be a redox active cluster 1, [Ti6O6(O(i)Pr)6(O2CFc)6]. An analogue 2, [Ti6O6(O(i)Pr)6(O2C(i)Bu)6], where the redox active ferrocene group is replaced by isobutyrate, is also reported as a contrast. The six ferrocene moieties in 1 are structurally identical to give a main redox wave at E1/2 = 0.62 V in dichloromethane investigated by cyclic voltammetry...
May 24, 2017: Inorganic Chemistry
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