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https://www.readbyqxmd.com/read/29223128/child-protective-services-utilization-of-child-abuse-pediatricians-a-mixed-methods-study
#1
Rebecca Girardet, Kelly Bolton, Syed Hashmi, Emily Sedlock, Rachna Khatri, Nina Lahoti, James Lukefahr
Several children's hospitals and medical schools across Texas have child abuse pediatricians (CAPs) who work closely with child protection workers to help ensure accurate assessments of the likelihood of maltreatment in cases of suspected abuse and neglect. Since the state does not mandate which cases should be referred to a CAP center, we were interested in studying factors that may influence workers' decisions to consult a CAP. We used a mixed methods study design consisting of a focus group followed by a survey...
December 6, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29223127/be-my-baby-patterning-toward-plant-germ-cells
#2
REVIEW
Keiji Nakajima
In flowering plants, germ cells are formed via tightly coordinated patterning processes that facilitate specification of spore mother cells and meiosis during sporogenesis, as well as functional differentiation of germ cells in gametogenesis. Studies using the conventional Arabidopsis system and the newly emerged bryophyte system have revealed novel interactions between regulatory factors that restrict the number of spore mother cells, and evolutionarily conserved factors that promote germ cell differentiation...
December 6, 2017: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/29223114/regional-conduction-velocity-calculation-from-clinical-multichannel-electrograms-in-human-atria
#3
Bhawna Verma, Tobias Oesterlein, Axel Loewe, Armin Luik, Claus Schmitt, Olaf Dössel
BACKGROUND: During atrial fibrillation, heterogeneities and anisotropies result in a chaotic propagation of the depolarization wavefront. The electrophysiological parameter called conduction velocity (CV) influences the propagation pattern over the atrium. We present a method that determines the regional CV for deformed catheter shapes, which result due to the catheter movement and changing wall contact. METHODS: The algorithm selects stable catheter positions, finds the local activation times (LAT), considers the wall contact and calculates all CV estimates within the area covered by the catheter...
November 26, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29223112/development-of-the-handwriting-legibility-scale-hls-a-preliminary-examination-of-reliability-and-validity
#4
Anna L Barnett, Mellissa Prunty, Sara Rosenblum
BACKGROUND: Demands for the production of legible handwriting produced in a timely manner increase as children progress through school. Despite the considerable number of children faced with handwriting difficulties, there is no quick and practical tool to assess legibility in this population. AIM: The aim of this study was to develop the Handwriting Legibility Scale (HLS) and to establish the scale's reliability and validity. METHODS: The HLS is a non-language dependent scale which assesses global legibility, based on five criteria applied to samples of 'free writing'...
December 6, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29223031/protonography-and-anion-inhibition-profile-of-the-%C3%AE-carbonic-anhydrase-cruca4-identified-in-the-mediterranean-red-coral-corallium-rubrum
#5
Sonia Del Prete, Daniela Vullo, Natacha Caminiti-Segonds, Didier Zoccola, Sylvie Tambutté, Claudiu T Supuran, Clemente Capasso
CruCA4 is a secreted isoform of the α-carbonic anhydrase (CA, EC 4.2.1.1) family, which has been identified in the octocoral Corallium rubrum. This enzyme is involved in the calcification process leading to the formation of the coral calcium carbonate skeleton. We report here experiments performed on the recombinant CruCA4 with the technique of protonography that can be used to detect in a simple way the enzyme activity. We have also investigated the inhibition profile of CruCA4 with one major class of CA inhibitors, the inorganic anions...
December 5, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29222948/force-coordination-strategies-in-on-water-single-sculling-are-asymmetries-related-to-better-rowing-performance
#6
John Warmenhoven, Richard Smith, Conny Draper, Andrew Harrison, Norma Bargary, Stephen Cobley
Asymmetries of the rowing stroke cycle have been assessed with reference to kinematics and foot-force measures in laboratory testing environments. It remains unclear how asymmetries in propulsive kinetic measures are related to on-water rowing performance. A new approach for the evaluation of both global and local asymmetries across the entire movement was used to assess the continuous role of asymmetries and whether these change according to level of competitive representation. Twenty seven highly skilled female rowers (national and international competition level), rowing at 32 strokes per minute in a single scull boat were evaluated...
December 9, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29222871/myelin-extracellular-leaflet-compaction-requires-apolipoprotein-d-membrane-management-to-optimize-lysosomal-dependent-recycling-and-glycocalyx-removal
#7
Nadia García-Mateo, Raquel Pascua-Maestro, Alberto Pérez-Castellanos, Concepción Lillo, Diego Sanchez, Maria D Ganfornina
To compact the extracellular sides of myelin, an important transition must take place: from membrane sliding, while building the wraps, to membrane adhesion and water exclusion. Removal of the negatively charged glycocalyx becomes the limiting factor in such transition. What is required to initiate this membrane-zipping process? Knocking-out the Lipocalin Apolipoprotein D (ApoD), essential for lysosomal functional integrity in glial cells, results in a specific defect in myelin extracellular leaflet compaction in peripheral and central nervous system, which results in reduced conduction velocity and suboptimal behavioral outputs: motor learning is compromised...
December 9, 2017: Glia
https://www.readbyqxmd.com/read/29222870/a-route-to-base-coordinate-silicon-difluoride-and-the-silicon-trifluoride-radical
#8
Herbert W Roesky, Soumen Sinhababu, Subrata Kundu, Alexander Paesch, Regine Herbst-Irmer, Dietmar Stalke, Israel Fernández, Gernot Frenking, Claudia Stückl, Brigitte Schwederski, Wolfgang Kaim
Silicon difluoride (SiF2) is highly unstable at room temperature and condenses at this temperature rapidly to a polymeric material of unknown structure. Therefore the isolation of a stable monomeric silicon difluoride species is a challenging task. The cyclic alkyl(amino) carbene (cAAC) coordinated silicon difluoride was isolated as (cAAC)2SiF2 (2), synthesized from the reduction of cAAC-SiF4 (1) using two equivalents of KC8 in the presence of one equivalent of cAAC. In the solid state compound 2 is stable at room temperature for a long time under inert conditions...
December 9, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29222849/bone-marrow-transplantation-improves-motor-activity-in-a-mouse-model-of-ataxia
#9
David Díaz, Marina Piquer-Gil, Javier Sánchez Recio, María Magdalena Martínez-Losa, José Ramón Alonso, Eduardo Weruaga, Manuel Álvarez-Dolado
Ataxias are locomotor disorders that can have an origin both neural and muscular, although both impairments are related. Unfortunately, ataxia has no cure and the current therapies are aimed at motor re-education or muscular reinforcement. Nevertheless, cell therapy is becoming a promising approach to deal with incurable neural diseases, including neuro-muscular ataxias. Here we have used a model of ataxia, the PCD mutant mouse, to study the effect of healthy (wild-type) bone marrow transplantation on the restoration of defective mobility...
December 8, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29222818/task-related-effective-connectivity-reveals-that-the-cortical-rich-club-gates-cortex-wide-communication
#10
Mario Senden, Niels Reuter, Martijn P van den Heuvel, Rainer Goebel, Gustavo Deco, Matthieu Gilson
Higher cognition may require the globally coordinated integration of specialized brain regions into functional networks. A collection of structural cortical hubs-referred to as the rich club-has been hypothesized to support task-specific functional integration. In the present paper, we use a whole-cortex model to estimate directed interactions between 68 cortical regions from functional magnetic resonance imaging activity for four different tasks (reflecting different cognitive domains) and resting state. We analyze the state-dependent input and output effective connectivity (EC) of the structural rich club and relate these to whole-cortex dynamics and network reconfigurations...
December 8, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29222733/frail-older-people-with-multi-morbidities-in-primary-care-a-new-integrated-care-clinical-pharmacy-service
#11
Lelly Oboh, Catherine Leon, Sulman Qadir, Felicity Smith, Sally-Anne Francis
Background Older people confined to their own homes due to frailty, multiple longterm conditions and/or complex needs, are known to be at risk of medicines-related problems. Whilst a health and social care team approach to supporting these patients is advocated, there is limited evidence regarding how pharmacists can best contribute. Objective To describe a new specialist pharmacy service (called the integrated care clinical pharmacist) in terms of how it works, what it achieves and its policy implications...
December 8, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29222726/non-auditory-electrophysiological-potentials-preceding-dolphin-biosonar-click-production
#12
James J Finneran, Jason Mulsow, Ryan Jones, Dorian S Houser, Alyssa W Accomando, Sam H Ridgway
The auditory brainstem response to a dolphin's own emitted biosonar click can be measured by averaging epochs of the instantaneous electroencephalogram (EEG) that are time-locked to the emitted click. In this study, averaged EEGs were measured using surface electrodes placed on the head in six different configurations while dolphins performed an echolocation task. Simultaneously, biosonar click emissions were measured using contact hydrophones on the melon and a hydrophone in the farfield. The averaged EEGs revealed an electrophysiological potential (the pre-auditory wave, PAW) that preceded the production of each biosonar click...
December 8, 2017: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/29222590/technical-accuracy-of-the-integration-of-an-external-ultrasonography-system-into-a-navigation-platform-effects-of-ultrasonography-probe-registration-and-target-detection
#13
Frederic A Wanis, Lars Wessels, Marcus H T Reinges, Eberhard Uhl, Andreas Jödicke
BACKGROUND: Intraoperative navigated ultrasonography has reached clinical acceptance, while published data for the accuracy of some systems are missing. We technically quantified and optimised the accuracy of the integration of an external ultrasonography system into a BrainLab navigation system. METHODS: A high-end ultrasonography system (Elegra; Siemens, Erlangen, Germany) was linked to a navigation system (Vector Vision; BrainLab, Munich, Germany). In vitro accuracy and precision was calculated from differences between a real world target (high-precision crosshair phantom) and the ultrasonography image of this target in the navigation coordinate system...
December 8, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29222513/biotrophy-necrotrophy-switch-in-pathogen-evoke-differential-response-in-resistant-and-susceptible-sesame-involving-multiple-signaling-pathways-at-different-phases
#14
Supriyo Chowdhury, Arpita Basu, Surekha Kundu
Infection stages of charcoal rot fungus Macrophomina phaseolina in sesame revealed for the first time a transition from biotrophy via BNS (biotrophy-to-necrotrophy switch) to necrotrophy as confirmed by transcriptional studies. Microscopy using normal and GFP-expressing pathogen showed typical constricted thick intercellular bitrophic hyphae which gave rise to thin intracellular necrotrophic hyphae during BNS and this stage was delayed in a resistant host. Results also show that as the pathogen switched its strategy of infection, the host tailored its defense strategy to meet the changing situation...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222438/new-insights-into-the-mechanism-of-nickel-superoxide-degradation-from-studies-of-model-peptides
#15
Daniel Tietze, Jana Sartorius, Banabithi Koley Seth, Kevin Herr, Pascal Heimer, Diana Imhof, Doreen Mollenhauer, Gerd Buntkowsky
A series of small, catalytically active metallopeptides, which were derived from the nickel superoxide dismutase (NiSOD) active site were employed to study the mechanism of superoxide degradation especially focusing on the role of the axial imidazole ligand. In the literature, there are contradicting propositions about the catalytic importance of the N-terminal histidine. Therefore, we studied the stability and activity of a set of eight NiSOD model peptides, which represent the major model systems discussed in the literature to date, yet differing in their length and their Ni-coordination...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222333/structural-determinants-of-bacterial-lytic-polysaccharide-monooxygenase-functionality
#16
Zarah Forsberg, Bastien Bissaro, Jonathan Gullesen, Bjørn Dalhus, Gustav Vaaje-Kolstad, Vincent G H Eijsink
Bacterial lytic polysaccharide monooxygenases (LPMO10s) use redox chemistry to cleave glycosidic bonds in the two foremost recalcitrant polysaccharides found in nature, namely cellulose and chitin. Analysis of correlated mutations revealed that the substrate-binding and copper-containing surface of LPMO10s comprises a network of coevolved residues and interactions, whose roles in LPMO functionality are unclear. Here, we mutated a subset of these correlated residues in a newly characterized C1/C4-oxidizing LPMO10 from Micromonospora aurantiaca (MaLPMO10B) to the corresponding residues in strictly C1-oxidizing LPMO10s...
December 8, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29222300/emerging-options-in-multiple-myeloma-targeted-immune-and-epigenetic-therapies
#17
REVIEW
Shaji Kumar
Considerable progress has been made in the treatment of multiple myeloma in the past decade with median survival for the disease improving significantly. This has come through a combination of better understanding of the disease biology and coordinated research into new treatment approaches including better supportive care. However, patients eventually become refractory to available treatments and succumb to the disease, highlighting the need to develop new treatment approaches. The genetic heterogeneity in the disease and clonal evolution under treatment pressure underlie the development of resistance, underscoring the need to develop more effective therapies that can eradicate the disease at initial treatment as well as the need for new classes of drugs with varying mechanisms of action...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29221607/leader-follower-formation-control-of-underactuated-surface-vehicles-based-on-sliding-mode-control-and-parameter-estimation
#18
Zhijian Sun, Guoqing Zhang, Yu Lu, Weidong Zhang
This paper studies the leader-follower formation control of underactuated surface vehicles with model uncertainties and environmental disturbances. A parameter estimation and upper bound estimation based sliding mode control scheme is proposed to solve the problem of the unknown plant parameters and environmental disturbances. For each of these leader-follower formation systems, the dynamic equations of position and attitude are analyzed using coordinate transformation with the aid of the backstepping technique...
December 5, 2017: ISA Transactions
https://www.readbyqxmd.com/read/29221411/augmented-potential-energy-densities-and-virial-relations-in-the-weak-and-strong-interaction-limits-of-dft
#19
Stefan Vuckovic, Mel Levy, Paola Gori-Giorgi
The augmented potential introduced by Levy and Zahariev [Phys. Rev. Lett. 113, 113002 (2014)] is shifted with respect to the standard exchange-correlation potential of the Kohn-Sham density functional theory by a density-dependent constant that makes the total energy become equal to the sum of the occupied orbital energies. In this work, we analyze several features of this approach, focusing on the limit of infinite coupling strength and studying the shift and the corresponding energy density at different correlation regimes...
December 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29221406/atomistic-simulations-of-the-equation-of-state-and-hybridization-of-liquid-carbon-at-a-temperature-of-6000-k-in-the-pressure-range-of-1-25-gpa
#20
V S Dozhdikov, A Yu Basharin, P R Levashov, D V Minakov
The equation of state and the structure of liquid carbon are studied by molecular simulation. Both classical and quantum molecular dynamics (QMD) are used to calculate the equation of state and the distribution of chemical bonds at 6000 K in the pressure range 1-25 GPa. Our calculations and results of other authors show that liquid carbon has a fairly low density on the order of 1.2-1.35 g/cm3 at pressures about 1 GPa. Owing to the coordination number analysis, this fact can be attributed to the high content of sp1-bonded atoms (more than 50% according to our ab initio computations)...
December 7, 2017: Journal of Chemical Physics
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