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https://www.readbyqxmd.com/read/27923220/differential-regulation-of-bmal1-clock-and-endothelial-signaling-in-the-aortic-arch-and-ligated-common-carotid-artery
#1
Xia Shang, Paramita Pati, Ciprian B Anea, David J R Fulton, R Daniel Rudic
The circadian clock is rhythmically expressed in blood vessels, but the interaction between the circadian clock and disturbed blood flow remains unclear. We examined the relationships between BMAL1 and CLOCK and 2 regulators of endothelial function, AKT1 and endothelial nitric oxide synthase (eNOS), in vascular regions of altered blood flow. We found that the aortic arch from WT mice exhibited reduced sensitivity to acetylcholine (Ach)-mediated relaxation relative to the thoracic aorta. In Clock-mutant (mut) mice the aorta exhibited a reduced sensitivity to Ach...
December 7, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27923067/chronological-lifespan-in-yeast-is-dependent-on-the-accumulation-of-storage-carbohydrates-mediated-by-yak1-mck1-and-rim15-kinases
#2
Lu Cao, Yingzhi Tang, Zhenzhen Quan, Zhe Zhang, Stephen G Oliver, Nianshu Zhang
Upon starvation for glucose or any other macronutrient, yeast cells exit from the mitotic cell cycle and acquire a set of characteristics that are specific to quiescent cells to ensure longevity. Little is known about the molecular determinants that orchestrate quiescence entry and lifespan extension. Using starvation-specific gene reporters, we screened a subset of the yeast deletion library representing the genes encoding 'signaling' proteins. Apart from the previously characterised Rim15, Mck1 and Yak1 kinases, the SNF1/AMPK complex, the cell wall integrity pathway and a number of cell cycle regulators were shown to be necessary for proper quiescence establishment and for extension of chronological lifespan (CLS), suggesting that entry into quiescence requires the integration of starvation signals transmitted via multiple signaling pathways...
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27922856/health-profiles-and-associated-service-use-among-adults-with-hiv-and-intellectual-and-developmental-disabilities
#3
Yona Lunsky, Anna Durbin, Hilary K Brown, Symron Bansal, Marina Heifetz, Tony Antoniou
OBJECTIVE (S): Due to the commonly held notion that individuals with intellectual and developmental disabilities (IDD) have low risk of HIV acquisition, we compared the prevalence of HIV infection among people with and without IDD. We also examined health status and health service use among the HIV-infected group. DESIGN: Population-based cohort study using linked administrative health and social services databases. METHODS: We compared HIV prevalence between Ontario adults with IDD (n=64,008) and a 20% random sample of Ontario adults without IDD...
December 5, 2016: AIDS
https://www.readbyqxmd.com/read/27922819/early-age-decline-in-dna-repair-capacity-in-the-liver-in-depth-profile-of-differential-gene-expression
#4
Avital Guedj, Anat Geiger-Maor, Eithan Galun, Hagai Amsalem, Jacob Rachmilewitz
Aging is associated with progressive decline in cell function and with increased damage to macromolecular components. DNA damage, in the form of double-strand breaks (DSBs), increases with age and in turn, contributes to the aging process and age-related diseases. DNA strand breaks triggers a set of highly orchestrated signaling events known as the DNA damage response (DDR), which coordinates DNA repair. However, whether the accumulation of DNA damage with age is a result of decreased repair capacity, remains to be determined...
November 30, 2016: Aging
https://www.readbyqxmd.com/read/27922816/the-progeroid-gene-bubr1-regulates-axon-myelination-and-motor-function
#5
Chan-Il Choi, Ki Hyun Yoo, Syed Mohammed Qasim Hussaini, Byeong Tak Jeon, John Welby, Haiyun Gan, Isobel A Scarisbrick, Zhiguo Zhang, Darren J Baker, Jan M van Deursen, Moses Rodriguez, Mi-Hyeon Jang
Myelination, the process by which oligodendrocytes form the myelin sheath around axons, is key to axonal signal transduction and related motor function in the central nervous system (CNS). Aging is characterized by degenerative changes in the myelin sheath, although the molecular underpinnings of normal and aberrant myelination remain incompletely understood. Here we report that axon myelination and related motor function are dependent on BubR1, a mitotic checkpoint protein that has been linked to progeroid phenotypes when expressed at low levels and healthy lifespan when overabundant...
September 12, 2016: Aging
https://www.readbyqxmd.com/read/27922612/the-intricate-dance-of-post-translational-modifications-in-the-rhythm-of-life
#6
REVIEW
Arisa Hirano, Ying-Hui Fu, Louis J Ptáček
Endogenous biological rhythms with approximately 24-h periodicity are generated by the circadian clock, in which clock genes coordinate with one another and form a transcriptional-translational negative feedback loop. The precision of the circadian clock is further regulated by multiple post-translational modifications (PTMs), including phosphorylation, ubiquitination, acetylation and SUMOylation. Here, we review current understanding of the regulatory mechanisms of the core clock proteins by PTMs in the mammalian circadian clock...
December 6, 2016: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/27922592/distributed-solar-photovoltaic-array-location-and-extent-dataset-for-remote-sensing-object-identification
#7
Kyle Bradbury, Raghav Saboo, Timothy L Johnson, Jordan M Malof, Arjun Devarajan, Wuming Zhang, Leslie M Collins, Richard G Newell
Earth-observing remote sensing data, including aerial photography and satellite imagery, offer a snapshot of the world from which we can learn about the state of natural resources and the built environment. The components of energy systems that are visible from above can be automatically assessed with these remote sensing data when processed with machine learning methods. Here, we focus on the information gap in distributed solar photovoltaic (PV) arrays, of which there is limited public data on solar PV deployments at small geographic scales...
December 6, 2016: Scientific Data
https://www.readbyqxmd.com/read/27922517/a-5-year-follow-up-of-study-patients-with-asymptomatic-iron-deficiency-anemia-using-a-nurse-led-pathway
#8
Sarah Ann Townsend, Danny Cheung, Elaine Horne, Rupert Ransford
A protocol-driven, systematic pathway was developed to allow rapid and coordinated investigation of patients with iron-deficiency anemia (IDA) in a nurse-delivered outpatient setting. The study objective was to assess the safety and efficacy of the pathway by 5-year outcome data for the exclusion of gastrointestinal (GI) malignancy. This is a 5-year follow-up study of 122 patients entered onto the pathway with negative initial upper and lower GI investigations. The study was conducted at Hereford County Hospital NHS Trust (a district general hospital serving 220,00 people)...
November 2016: Gastroenterology Nursing: the Official Journal of the Society of Gastroenterology Nurses and Associates
https://www.readbyqxmd.com/read/27922462/fostering-evidence-based-quality-improvement-for-patient-centered-medical-homes-initiating-local-quality-councils-to-transform-primary-care
#9
Susan E Stockdale, Jessica Zuchowski, Lisa V Rubenstein, Negar Sapir, Elizabeth M Yano, Lisa Altman, Jacqueline J Fickel, Skye McDougall, Timothy Dresselhaus, Alison B Hamilton
BACKGROUND: Although the patient-centered medical home endorses quality improvement principles, methods for supporting ongoing, systematic primary care quality improvement have not been evaluated. We introduced primary care quality councils at six Veterans Health Administration sites as an organizational intervention with three key design elements: (a) fostering interdisciplinary quality improvement leadership, (b) establishing a structured quality improvement process, and (c) facilitating organizationally aligned frontline quality improvement innovation...
December 3, 2016: Health Care Management Review
https://www.readbyqxmd.com/read/27922202/current-practices-for-screening-consent-and-care-of-related-donors-in-france-haematopoietic-stem-cell-transplantation-coordinator-nurses-perceptions
#10
A Polomeni, C Bompoint, A Gomez, E Brissot, A Ruggeri, R Belhocine, M Mohty
Haematopoietic stem cell transplantation-coordinating nurses (HSCT-CNs) play an important role in informing related donors (RDs) and in organising human leucocyte antigen (HLA) tests, pre-donation workup and stem cells collection. Our pilot study aimed to explore French HSCT-CNs' perceptions of RD care issues. Twenty-nine French HSCT adult units were sent a questionnaire on the subject of donation procedures, HSCT-CNs' data and their professional experience of related donation issues. Twenty-two HSCT-CNs returned a completed questionnaire, and 90% of HSCT units were involved to some degree in both patient and donor care...
December 6, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27922171/connexins-and-pannexins-from-biology-towards-clinical-targets
#11
Paolo Meda, Jacques-Antoine Haefliger
Efficient cell communication is a prerequisite for the coordinated function of tissues and organs. In vertebrates, this communication is mediated by a variety of mechanisms, including the exchange of molecules between cells, and between cells and the extracellular medium, via membrane channels made of connexin and pannexin proteins. These channels are a necessary component of all human tissues. Here, we review the biological essentials of the connexin and pannexin families, and the roles of these proteins in the function of cells which are central to major human diseases...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27922101/social-determinants-of-eyeblinks-in-adult-male-macaques
#12
Sébastien Ballesta, Clayton P Mosher, Jeno Szep, Kate D Fischl, Katalin M Gothard
Videos with rich social and emotional content elicit natural social behaviors in primates. Indeed, while watching videos of conspecifics, monkeys engage in eye contact, gaze follow, and reciprocate facial expressions. We hypothesized that the frequency and timing of eyeblinks also depends on the social signals contained in videos. We monitored the eyeblinks of four male adult macaques while they watched videos of conspecifics displaying facial expressions with direct or averted gaze. The instantaneous blink rate of all four animals decreased during videos...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27922082/optimized-invisibility-cloaks-from-the-logarithm-conformal-mapping
#13
Chunhui Zhu, Lijun Liu, Zhengyong Song, Qing Huo Liu
Invisibility cloaks designed from the coordinate transformation method have attracted increasing interest recently. Conformal transformation optics scheme leads to cloaks that possess isotopic media, thus provides a prospective way to facilitate easier realization. Reducing the maximum value of the refractive index required by the cloaks is very important in practical imple- mentation. This letter studies on how the parameters in the logarithm conformal mapping control the cloaking effect. The optimized invisibility cloaks are designed...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27922053/electrophysiological-properties-of-ca1-pyramidal-neurons-along-the-longitudinal-axis-of-the-mouse-hippocampus
#14
Giampaolo Milior, Maria Amalia Di Castro, Livio Pepe' Sciarria, Stefano Garofalo, Igor Branchi, Davide Ragozzino, Cristina Limatola, Laura Maggi
Evidence for different physiological properties along the hippocampal longitudinal axis is emerging. Here, we examined the electrophysiological features of neurons at different dorso-ventral sites of the mouse CA1 hippocampal region. Cell position was defined with respect to longitudinal coordinates of each slice. We measured variations in neuronal excitability, subthreshold membrane properties and neurotransmitter responses along the longitudinal axis. We found that (i) pyramidal cells of the dorsal hippocampus (DH) were less excitable than those of the ventral hippocampus (VH)...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27922002/targeting-the-notch-regulated-non-coding-rna-tug1-for-glioma-treatment
#15
Keisuke Katsushima, Atsushi Natsume, Fumiharu Ohka, Keiko Shinjo, Akira Hatanaka, Norihisa Ichimura, Shinya Sato, Satoru Takahashi, Hiroshi Kimura, Yasushi Totoki, Tatsuhiro Shibata, Mitsuru Naito, Hyun Jin Kim, Kanjiro Miyata, Kazunori Kataoka, Yutaka Kondo
Targeting self-renewal is an important goal in cancer therapy and recent studies have focused on Notch signalling in the maintenance of stemness of glioma stem cells (GSCs). Understanding cancer-specific Notch regulation would improve specificity of targeting this pathway. In this study, we find that Notch1 activation in GSCs specifically induces expression of the lncRNA, TUG1. TUG1 coordinately promotes self-renewal by sponging miR-145 in the cytoplasm and recruiting polycomb to repress differentiation genes by locus-specific methylation of histone H3K27 via YY1-binding activity in the nucleus...
December 6, 2016: Nature Communications
https://www.readbyqxmd.com/read/27921634/smoking-cessation-in-smoke-free-prisons-a-grounded-theory-study
#16
Ashleigh Djachenko, Winsome St John, Creina Mitchell
Purpose Prisoners are vulnerable to tobacco addiction and have a smoking prevalence significantly higher than that of the general community. The context of this study was the implementation of a "smoke-free prisons" policy, which imposed forced smoking cessation onto the Queensland, Australian prison population. The study asked the question: "What are the psychosocial processes in which male prisoners engage during smoking cessation in a smoke-free environment?" Design/methodology/approach Qualitative interviews were conducted with 15 prisoners in South-east Queensland smoke-free correctional centres...
December 19, 2016: International Journal of Prisoner Health
https://www.readbyqxmd.com/read/27921100/hierarchical-self-assembly-of-a-fluorescence-emission-enhanced-organogelator-and-its-multiple-stimuli-responsive-behaviors
#17
Yuan-Yuan Ren, Zheng Xu, Guoqiang Li, Junhai Huang, Xiaotian Fan, Lin Xu
A discrete hexagonal metallacycle 1 decorated with tetraphenylethylene, amide groups and long hydrophobic alkyl chains was constructed via [3 + 3] coordination-driven self-assembly, from which the fluorescence emission-enhanced organogelator with multiple stimuli-responsiveness was successfully prepared via hierarchical self-assembly.
December 6, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27920928/-trans-chlorido-2-rp-2-methyl-sulfan-yl-ferro-cen-yl-2-5-6-7-tetra-hydro-pyrrolo-1-2-c-imidazol-3-yl-idene-bis-tri-phenyl-phosphane-%C3%AE%C2%BAp-palladium-ii-hexa-fluorido-phosphate-di-chloro-form-disolvate
#18
Cody Wilson-Konderka, Alan J Lough, Costa Metallinos
The title solvated complex, [FePd(C5H5)(C12H13N2S)Cl(C18H15P)2]PF6·2CHCl3, bearing a chiral ferrocenyl pyrrolo-imidazolyl-idene N-heterocyclic carbene (NHC) ligand, was synthesized by oxidative addition of a chloro-imidazolium salt to Pd(PPh3)4. The Pd(II) ion is coordinated in a slightly distorted square-planar coordination geometry, with the Cl atom trans to the coordinating C atom of the pyrrolo-imidazolyl-idene ligand. The complex features a pendant thio-ether group that is not involved in coordination to Pd...
September 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/27920925/crystal-structure-of-bamnb2o5-containing-structurally-isolated-manganese-oxide-sheets
#19
Elizabeth M Maschmeyer, Liurukara D Sanjeewa, Kulugammana G S Ranmohotti
In an attempt to search for mixed alkaline-earth and transition metal pyroborates, the title compound, barium manganese(II) pyroborate, has been synthesized by employing a flux method. The structure of BaMnB2O5 is composed of MnO5 square pyramids that form Mn2O8 dimers by edge-sharing and of pyroborate units ([B2O5](4-)) that are composed of two corner-sharing trigonal-planar BO3 units. These building blocks share corners to form ∞(2)[MnB2O5](2-) layers extending parallel to (100). The Ba(2+) cations reside in the gap between two manganese pyroborate slabs with a coordination number of nine...
September 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/27920921/a-two-dimensional-cd-ii-coordination-polymer-poly-di-aqua-%C3%AE-3-5-6-bis-pyridin-2-yl-pyrazine-2-3-di-carboxyl-ato-%C3%AE%C2%BA-5-o-2-o-3-o-3-n-4-n-5-cadmium
#20
Monserrat Alfonso, Helen Stoeckli-Evans
The reaction of 5,6-bis-(pyridin-2-yl)pyrazine-2,3-di-carb-oxy-lic acid with cadmium dichloride leads to the formation of the title two-dimensional coordination polymer, [Cd(C16H8N4O4)(H2O)2] n . The metal atom is sevenfold coordinated by one pyrazine and one pyridine N atom, two water O atoms, and by two carboxyl-ate O atoms, one of which bridges two Cd(II) atoms to form a Cd2O2 unit situated about a centre of inversion. Hence, the ligand coordinates to the cadmium atom in an N,N',O-tridentate and an O-monodentate manner...
September 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
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