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Epithelial mesenchymal transition

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https://www.readbyqxmd.com/read/29690747/tumor-associated-macrophages-derived-tgf-%C3%AE-%C3%A2-induced-epithelial-to-mesenchymal-transition-in-colorectal-cancer-cells-through-smad2-3-4-snail-signaling-pathway
#1
Jianhui Cai, Limin Xia, Jinlei Li, Shichang Ni, Huayu Song, Xiangbin Wu
Purpose: We investigated the role of tumor-associated macrophages (TAMs) on the epithelial to mesenchymal transition (EMT) of colorectal cancer cells and determined the potential mechanism involved in the metastatic process. Materials and Methods: In this study, flow cytometry was used to detect the expression of target proteins. We used transwell assay to evaluate the migration of cancer cells under specific conditions. Using real-time polymerase chain reaction, we examined the expressions of cytokines and EMT-related markers in mRNA level...
April 25, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29689643/il-17a-promotes-the-invasion-metastasis-cascade-via-the-akt-pathway-in-hepatocellular-carcinoma
#2
Qing-Guo Xu, Jian Yu, Xing-Gang Guo, Guo-Jun Hou, Sheng-Xian Yuan, Yuan Yang, Yun Yang, Hui Liu, Ze-Ya Pan, Fu Yang, Fang-Ming Gu, Wei-Ping Zhou
We previously demonstrated that interleukin-17A (IL-17A) is associated with the progression of hepatocellular carcinoma (HCC). However, its role in the invasion-metastasis cascade of HCC and the efficacy of IL-17A-targeting therapeutics in HCC remain largely unknown. In this study, we found that IL-17A promoted intrahepatic and pulmonary metastasis of HCC cells in an orthotopic implant model. Moreover, our results showed that IL-17A induced epithelial-mesenchymal transition (EMT) and promoted HCC cell colonization in vitro and in vivo, and the role of IL-17A in invasion-metastasis was dependent on activation of the AKT pathway...
April 24, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29689552/rbfox3-regulates-the-chemosensitivity-of-cancer-cells-to-5-fluorouracil-via-the-pi3k-akt-emt-and-cytochrome-c-caspase-pathways
#3
Tianze Liu, Xiaojun Wu, Yizhuo Li, Wenjing Lu, Fufu Zheng, Changlin Zhang, Qian Long, Huijuan Qiu, Yixin Li, Qin Ge, Miao Chen, Xinfa Yu, Wangbing Chen, Hongyang Zhang, Wenlin Huang, Meihua Luo, Wuguo Deng, Liren Li
BACKGROUND/AIMS: RBFOX3, an RNA-binding fox protein, plays an important role in the differentiation of neuronal development, but its role in the chemosensitivity of hepatocellular carcinoma (HCC) to 5-FU is unknown. METHODS: In this study, we examined the biological functions of RBFOX3 and its effect on the chemosensitivity of HCC cells to 5-FU in vitro and in a mouse xenograft model. RESULTS: RBFOX3 was found to have elevated expression in HCC cell lines and tissue samples, and its knockdown inhibited HCC cell proliferation...
April 18, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29689350/hsa_circ_0079530-promotes-cell-proliferation-and-invasion-in-non-small-cell-lung-cancer
#4
Jipeng Li, Jianhua Wang, Zhe Chen, Yin Chen, Mingwei Jin
Circular RNAs (circRNAs) play a crucial role in the occurrence of several diseases including cancers. However, little is known about their role in Non-small cell lung cancer (NSCLC). In the present study, we found that hsa_circ_0075930 expression levels were significantly higher in NSCLC cell lines and tissues. The elevated hsa_circ_0075930 expression was correlated with tumor size (P = 0.001) and Lymph node metastasis (P = 0.038). Functional experiments showed knockdown of hsa_circ_0075930 followed by RNA silencing restrained cell proliferation and induced cell cycle arrest of NSCLC cells...
April 21, 2018: Gene
https://www.readbyqxmd.com/read/29689273/melatonin-inhibits-osteosarcoma-stem-cells-by-suppressing-sox9-mediated-signaling
#5
Hao Qu, Yue Xue, Wenwen Lian, Cong Wang, Jia He, Qihong Fu, Lijia Zhong, Nong Lin, Lihua Lai, Zhaoming Ye, Qingqing Wang
AIMS: Melatonin (N-acetyl-5-methoxytryptamine) has been reported to suppress epithelial-mesenchymal transition and cancer stem cells in some types of cancer. However, the effects of melatonin on the osteosarcoma stem cells, epithelial-mesenchymal transition and metastasis of osteosarcoma are still not clear. The present study was conducted to dissect the activity of melatonin on the osteosarcoma stem cells and the underlying mechanisms. MAIN METHODS: MTT, wound healing, transwell assay and western blotting were conducted to determine the effect of melatonin on osteosarcoma cell invasion and migration and downregulation of SOX9-mediated signaling...
April 21, 2018: Life Sciences
https://www.readbyqxmd.com/read/29689047/nanogp8-is-the-key-regulator-of-stemness-emt-wnt-pathway-chemoresistance-and-other-malignant-phenotypes-in-gastric-cancer-cells
#6
Xia Ma, Bei Wang, Xiaofang Wang, Yujiao Luo, Wufang Fan
BACKGROUND: Accumulating evidence demonstrated that NANOG1, the key transcription factor for embryonic stem cells, is associated with human cancers. NANOGP8, one of the pseudogenes in NANOG gene family, contains an intact open reading frame and also said to be expressed in cancer tissues. Therefore, a systematic study is greatly needed to address the following questions: among NANOG1 and NANOGP8, which gene is the main contributor for NANOG expression in cancer cells and which one is the key regulator responsible for stemness, epithelial-mesenchymal transition (EMT), metastasis, chemoresistance and other malignant phenotypes...
2018: PloS One
https://www.readbyqxmd.com/read/29688883/high-microrna-28-5p-expression-in-colorectal-adenocarcinoma-predicts-short-term-relapse-of-node-negative-patients-and-poor-overall-survival-of-patients-with-non-metastatic-disease
#7
Panagiotis Tsiakanikas, Christos K Kontos, Dimitrios Kerimis, Iordanis N Papadopoulos, Andreas Scorilas
BACKGROUND: MicroRNAs (miRNAs) may function either as oncogenes or tumor suppressors and are heavily involved in the initiation and progression of cancer, and in metastasis of tumor cells. MicroRNA-28-5p (miR-28-5p) targets several cancer-related genes and is hence involved in cell proliferation, migration, invasion and epithelial-mesenchymal transition. In this study, we investigated the potential diagnostic and prognostic significance of miR-28-5p expression in colorectal adenocarcinoma, the most frequent type of colorectal cancer (CRC)...
April 24, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29687851/mir-132-weakens-proliferation-and-invasion-of-glioma-cells-via-the-inhibition-of-gli1
#8
Y-Z Wang, J-J Han, S-Q Fan, W Yang, Y-B Zhang, T-J Xu, G-M Xu
OBJECTIVE: Transcriptional factor Gli1 in Hedgehog signal pathway facilitates epithelial mesenchymal transition (EMT) and is associated with invasion or proliferation of multiple tumor cells. The previous study showed the correlation between miR-132 down-regulation and glioma pathogenesis. We investigated the role of miR-132 in mediating Gli1 expression and in affecting proliferation or invasion of glioma cells. PATIENTS AND METHODS: Dual luciferase reporter gene assay was used to confirm the targeted regulation between miR-132 and Gli1...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29685144/emerging-roles-of-epithelial-mesenchymal-transition-in-hematological-malignancies
#9
REVIEW
San-Chi Chen, Tsai-Tsen Liao, Muh-Hwa Yang
BACKGROUND: Epithelial-mesenchymal transition is an important process in embryonic development, fibrosis, and cancer metastasis. During the progression of epithelial cancer, activation of epithelial-mesenchymal transition is tightly associated with metastasis, stemness and drug resistance. However, the role of epithelial-mesenchymal transition in non-epithelial cancer is relatively unclear. MAIN BODY: Epithelial-mesenchymal transition transcription factors are critical in both myeloid and lymphoid development...
April 23, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29684855/post-transcription-mediated-snail-stabilization-is-involved-in-radiation-exposure-induced-invasion-and-migration-of-hepatocarcinoma-cells
#10
Liyang Dong, Xuebang Zhang, Wei Xiang, Junwei Ni, Weizhong Zhou, Haiyan Li
Increasing evidences suggested that radiotherapy can paradoxically promote tumor invasion and metastatic processes, while its detailed mechanism is not well illustrated. Our present study found that radiation can promote the migration and invasion of hepatocellular carcinoma (HCC) cells via induction of epithelial mesenchymal transition (EMT), which was evidenced by the results that radiation induced up regulation of vimentin while down regulation of E-Cadherin. As to the EMT-related transcription factors, radiation increased the expression of Snail, while not Slug, ZEB1 or TWIST...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684852/polysaccharide-from-rhizopus-nigricans-inhibits-the-invasion-and-metastasis-of-colorectal-cancer
#11
Zhidan Yu, Qingjie Sun, Jing Liu, Xiujuan Zhang, Ge Song, Guodong Wang, Pengying Zhang, Kaoshan Chen
Polysaccharide (EPS1-1) extracted from fermentation liquor of Rhizopus nigricans possesses antitumor and immune-enhancing activities. The study was the first to investigate the anti-metastasis effects of EPS1-1 in vitro and in vivo. Results suggested that EPS1-1 dose-dependently suppressed the migration, invasion and adhesion abilities of CT26 cells. Furthermore, EPS1-1 dramatically inhibited the enzyme activity and expression levels of matrix metalloproteinases (MMPs) in CT26 cells, as well as the tube formation of HUVECs...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684384/knockdown-of-poldip2-suppresses-tumor-growth-and-invasion-capacity-and-is-linked-to-unfavorable-transformation-ability-and-metastatic-feature-in-non-small-cell-lung-cancer
#12
Ying-Chieh Chen, Chih-Chi Kuo, Chih-Feng Chian, Ching Tzao, Shan-Yueh Chang, Yu-Lueng Shih, Ya-Wen Lin, Mu-Hsien Yu, Her-Young Su
The main problem in the treatment of non-small cell lung cancer (NSCLC) is metastasis. Epithelial-mesenchymal transition (EMT) is known as the critical signaling in tumor progression, metastasis, and also the drug resistance. In this study, we reported a novel gene Polymerase delta-interacting protein 2 (POLDIP2) was downregulated in NSCLC tissues and first demonstrated that overexpression of POLDIP2 increased the anchorage-independent growth (AIG) and invasiveness of H1299 cells. In addition, we examined that knockdown of POLDIP2 in H1299 and A549 cells reduced tumorigenicity and metastatic capacity in vitro and also in vivo...
April 20, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29683892/implication-of-highly-cytotoxic-natural-killer-cells-for-esophageal-squamous-cell-carcinoma-treatment
#13
Kee Siang Lim, Kosaku Mimura, Ley-Fang Kua, Kensuke Shiraishi, Koji Kono
Esophageal squamous cell carcinoma (ESCC) is an aggressive upper gastrointestinal cancer and effective treatments are limited. Previous studies reported that natural killer (NK) cells expanded by coculturing with K562-mb15-41BBL feeder cells, a genetically modified K562 leukemia cell line that expresses membrane-bound interleukin (IL)-15 and 41BBL ligand, were highly proliferative and highly cytotoxic. Here, we investigated the potential of expanded NK cells for ESCC treatment. We analyzed both genetic and surface expression levels of NKG2D ligands (NKG2DLs) in ESCC using publicly available microarray data sets and ESCC cell lines...
April 20, 2018: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29683756/de-novo-expression-of-transfected-sirtuin-3-enhances-susceptibility-of-human-mcf-7-breast-cancer-cells-to-hyperoxia-treatment
#14
Marija Pinterić, Iva I Podgorski, Sandra Sobočanec, Marijana Popović Hadžija, Mladen Paradžik, Ana Dekanić, Maja Marinović, Mirna Halasz, Robert Belužić, Grazia Davidović, Andreja Ambriović Ristov, Tihomir Balog
Sirtuin 3 (Sirt3) has a promising role in cancer tumourigenesis and treatment, but there have been controversies about its role as oncogene or tumour suppressor in different types of cancer. Changes in its expression are associated with the excessive production of reactive oxygen species (ROS), thus contributing to mitochondrial dysfunction and age-related pathologies. Hyperoxic treatment (i.e. generator of ROS) was shown to support some tumourigenic properties, but finally suppresses growth of certain mammary carcinoma cells...
April 23, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29683754/micrornas-in-idiopathic-pulmonary-fibrosis-new-research-progress-and-their-pathophysiological-implication
#15
Chenggui Miao, Youyi Xiong, Guoxue Zhang, Jun Chang
Many studies have shown that microRNAs (miRNAs) play important roles in the development of idiopathic pulmonary fibrosis (IPF). The purpose of this review is to systematically summarize the recent advance of miRNAs in the pathology of IPF, highlighting the new research progress and their pathophysiological implication. Recent studies have shown that miRNAs differentially expressed in blood and lung tissue from IPF patients are closely related to the occurrence of IPF disease, which may be IPF diagnostic markers and prognostic indicators...
April 23, 2018: Experimental Lung Research
https://www.readbyqxmd.com/read/29682563/deregulation-of-hexokinase-ii-is-associated-with-glycolysis-autophagy-and-the-epithelial-mesenchymal-transition-in-tongue-squamous-cell-carcinoma-under-hypoxia
#16
Guanhui Chen, Yadong Zhang, Jianfeng Liang, Wenqing Li, Yue Zhu, Ming Zhang, Cheng Wang, Jinsong Hou
The glycolytic enzyme Hexokinase (HKII) participates in tumor glycolysis and the progression of various cancers, but its clinicopathological effect on the progression of tongue squamous cell carcinoma (TSCC) and its role in glycolysis, autophagy, and the epithelial-mesenchymal transition of TSCC in a hypoxic microenvironment remain unknown. Our results showed that HKII expression was dramatically increased in TSCC tissues and that its upregulation was significantly associated with the presence of pathological differentiation, lymph node metastasis, and clinical stage...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29682444/molecular-detection-of-emt-markers-in-circulating-tumor-cells-from-metastatic-non-small-cell-lung-cancer-patients-potential-role-in-clinical-practice
#17
Annalisa Milano, Francesca Mazzetta, Sabatino Valente, Danilo Ranieri, Laura Leone, Andrea Botticelli, Concetta Elisa Onesti, Salvatore Lauro, Salvatore Raffa, Maria Rosaria Torrisi, Paolo Marchetti
Background: Non-small cell lung cancer (NSCLC) is the most common cause of cancer-related mortality; nevertheless, there are few data regarding detection of circulating tumor cells (CTCs) in NSCLC, compared to other kinds of cancers in which their prognostic roles have already been defined. This difference is likely due to detection methods based on the epithelial marker expression which ignore CTCs undergoing epithelial-mesenchymal transition (CTCsEMT ). Methods: After optimization of the test with spiking experiments of A549 cells undergoing TGF- β 1-induced EMT (A549EMT ), the CTCsEMT were enriched by immunomagnetic depletion of leukocytes and then characterized by a RT-PCR assay based on the retrieval of epithelial and EMT-related genes...
2018: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/29681982/propolin-c-inhibited-migration-and-invasion-via-suppression-of-egfr-mediated-epithelial-to-mesenchymal-transition-in-human-lung-cancer-cells
#18
Jih-Tung Pai, Yi-Chin Lee, Si-Ying Chen, Yann-Lii Leu, Meng-Shih Weng
Controlling lung cancer cell migration and invasion via epithelial-to-mesenchymal transition (EMT) through the regulation of epidermal growth factor receptor (EGFR) signaling pathway has been demonstrated. Searching biological active phytochemicals to repress EGFR-regulated EMT might prevent lung cancer progression. Propolis has been used as folk medicine in many countries and possesses anti-inflammatory, antioxidant, and anticancer activities. In this study, the antimigration and anti-invasion activities of propolin C, a c-prenylflavanone from Taiwanese propolis, were investigated on EGFR-regulated EMT signaling pathway...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29681769/epithelial-to-mesenchymal-transition-induces-stem-cell-like-phenotype-in-renal-cell-carcinoma-cells
#19
Mamta Singla, Ajay Kumar, Amanjit Bal, Subhendu Sarkar, Shalmoli Bhattacharyya
Background: Metastatic dissemination of solid tumors is often initiated by reactivation of an embryonic development program, epithelial-to-mesenchymal-transition (EMT). EMT has been associated with acquiring invasiveness and resistance to conventional therapies. However, the precise role of EMT during renal cell carcinoma is still debatable and is under investigation. In this context, our study is designed to evaluate the role of cyclosporine (CsA) and transforming growth factor-β (TGFβ) administration in inducing EMT-like state in renal carcinoma cells...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29679906/microrna-876-5p-inhibits-epithelial-mesenchymal-transition-and-metastasis-of-hepatocellular-carcinoma-by-targeting-bcl6-corepressor-like-1
#20
Qiuran Xu, Qiaojuan Zhu, Zhenyu Zhou, Yufeng Wang, Xin Liu, Guozhi Yin, Xiangmin Tong, Kangsheng Tu
Our previous study has reported that BCL6 corepressor like 1 (BCORL1) plays an oncogenic role in hepatocellular carcinoma (HCC) via promoting epithelial-mesenchymal transition (EMT) and tumor metastasis. However, the regulation of BCORL1 mediated by microRNAs (miRNAs) remains poorly known. The analysis of our clinical samples indicated that BCORL1 expression was markedly higher in HCC tissues than that in tumor-adjacent normal tissues. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets revealed that high BCORL1 expression associated with high tumor grade, advanced tumor stage and poor survival of HCC patients...
April 18, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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