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Epithelial mesenchymal transition

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https://www.readbyqxmd.com/read/29475041/antrodia-cinnamomea-mycelial-fermentation-broth-inhibits-the-epithelial-mesenchymal-transition-of-human-esophageal-adenocarcinoma-cancer-cells
#1
Yu-Ming Liu, Yu-Kuo Liu, Pin-I Huang, Tung-Hu Tsai, Yu-Jen Chen
Esophageal cancer is associated with a high mortality rate and easy metastasis. The aim of this study is to investigate the effect of the bio-product Antrodia cinnamomea mycelial fermentation broth (AC-MFB) on the epithelial mesenchymal transition (EMT) of human esophageal cancer cells and the molecular mechanisms underlying these effects. Transforming growth factor β (TGF-β) was used to induce EMT in human esophageal BE3 cancer cells. Changes in cell morphology and migration potential were examined. The expression of E-cadherin, N-cadherin, vimentin, and other transcriptional factors was studied by western blot assay...
February 20, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29475036/adamts-6-is-a-predictor-of-poor-prognosis-in-patients-with-esophageal-squamous-cell-carcinoma
#2
Lan Liu, Zhaoting Yang, Weidong Ni, Yanhua Xuan
BACKGROUND: A disintegrin and metalloprotease with thrombospondin motif (ADAMTS) enzymes play important roles in cell functions including adhesion, invasion, migration, and proliferation. ADAMTS-6 is a member of the ADAMTS family; reports of its relationship with esophageal squamous cell carcinoma (ESCC) progression are rare. It is unclear whether ADAMTS-6 could be an independent ESCC biomarker. METHODS: ADAMTS-6 expression was detected by immunohistochemistry (IHC) in 171 paraffin-embedded ESCC specimens; relationships with patients' clinicopathological features and Twist-1 expression were analyzed by the Pearson Chi-square method, respectively...
February 20, 2018: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29474900/hepatoprotective-effect-of-forsythiae-fructuse-water-extract-against-carbon-tetrachloride-induced-liver-fibrosis-in-mice
#3
Yi Zhang, Hui Miao, Hongyu Yan, Yuchen Sheng, Lili Ji
ETHNOPHARMACOLOGICAL RELEVANCE: The fruit of Forsythia suspensa (Thunb.) Vahl, named Forsythiae Fructus (Lian-Qiao), is a well-known traditional Chinese medicine (TCM) used for clearing away heat and toxic material, eliminating the mass and relieving swelling. AIM OF THE STUDY: This study aims to observe the attenuation of the water extract of Forsythiae Fructus (FSE) on carbon tetrachloride (CCl4 )-induced hepatic fibrosis in male C57BL/6 mice. MATERIALS AND METHODS: Hepatic fibrosis was induced in male C57BL/6 mice by intraperitoneal injection with 2ml/kg CCl4 (mixed 1: 3 in olive oil) twice a week for 4 weeks...
February 20, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29473166/capillary-morphogenesis-protein-2-is-a-novel-prognostic-biomarker-and-plays-oncogenic-roles-in-glioma
#4
Juan Tan, Mei Liu, Jun-Ying Zhang, Yue-Liang Yao, Yan-Xia Wang, Yong Lin, Kang Song, Jiao Tan, Jin-Rong Wu, You-Hong Cui, Yan Wang, Xiu-Wu Bian
Capillary morphogenesis protein 2 (CMG2) was originally identified through its participation in capillary morphogenesis, and subsequently identified as the second receptor for anthrax toxin (ANTXR2). Although tumor-associated functions of CMG2 have also been reported, the clinical significance and functional mechanism of CMG2 in glioma remain to be elucidated. We assessed the clinicopathological relevance of CMG2 in a cohort of 48 glioma patients as well as through public glioma databases, and explored the function of CMG2 using glioblastoma (GBM) models in vitro and in vivo...
February 23, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29472634/hakai-overexpression-effectively-induces-tumour-progression-and-metastasis-in-vivo
#5
Raquel Castosa, Olaia Martinez-Iglesias, Daniel Roca-Lema, Alba Casas-Pais, Andrea Díaz-Díaz, Pilar Iglesias, Isabel Santamarina, Begoña Graña, Lourdes Calvo, Manuel Valladares-Ayerbes, Ángel Concha, Angélica Figueroa
At early stages of carcinoma progression, epithelial cells undergo a program named epithelial-to-mesenchymal transition characterized by the loss of the major component of the adherens junctions, E-cadherin, which in consequence causes the disruption of cell-cell contacts. Hakai is an E3 ubiquitin-ligase that binds to E-cadherin in a phosphorylated-dependent manner and induces its degradation; thus modulating cell adhesions. Here, we show that Hakai expression is gradually increased in adenoma and in different TNM stages (I-IV) from colon adenocarcinomas compared to human colon healthy tissues...
February 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29472550/pim1-mediates-epithelial-mesenchymal-transition-by-targeting-smads-and-c-myc-in-the-nucleus-and-potentiates-clear-cell-renal-cell-carcinoma-oncogenesis
#6
Bin Zhao, Lei Liu, Jun Mao, Zhiwei Zhang, Qifei Wang, Quanlin Li
Emerging evidence has shown that the PIM serine/threonine kinase family, including PIM1, PIM2 and PIM3, is associated with tumour progression towards metastasis. PIM1, an attractive molecular target, has been identified as a potential prognostic biomarker for haematological and epithelial malignancies. However, to date, the potential regulatory roles and molecular mechanisms by which PIM1 affects the development and progression of cancers, including clear-cell renal-cell carcinoma (ccRCC), remain largely unknown...
February 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29472529/a-novel-microrna-identified-in-hepatocellular-carcinomas-is-responsive-to-lef1-and-facilitates-proliferation-and-epithelial-mesenchymal-transition-via-targeting-of-nfix
#7
Yaqi Hu, Xu Guo, Jinxia Wang, Yankun Liu, Huijie Gao, Hongxia Fan, Xiangyang Nong, Xi Yang, Min Liu, Shengping Li, Hua Tang
Hepatocellular carcinoma (HCC) is one of the most prevalent cancers. It has been demonstrated that various cellular microRNAs (miRNAs) play an important role in HCC development. Here, we analyzed the miRNA profile in HCC tissues by Solexa sequencing, and we identified a novel microRNA, miR-HCC1, which is upregulated in HCC tissues. Further experiments showed that miR-HCC1 promoted HCC cell proliferation in vivo and in vitro, and migration and invasion resulting from the epithelial-mesenchymal transition (EMT) process...
February 23, 2018: Oncogenesis
https://www.readbyqxmd.com/read/29471888/liquiritigenin-inhibits-colorectal-cancer-proliferation-invasion-and-epithelial-to-mesenchymal-transition-by-decreasing-expression-of-runt-related-transcription-factor-2
#8
Fan-Chun Meng, Jun-Kai Lin
Inhibition of tumor metastasis is one of the most important purposes in colorectal cancer (CRC) treatment. This study aimed to explore the effects of liquiritigenin, one of flavonoids extracted from the roots of Glycyrrhiza uralensis Fisch , on HCT116 cell proliferation, invasion, and epithelial to mesenchymal transition (EMT). We found that liquiritigenin significantly inhibited HCT116 cell proliferation, invasion and EMT process but had no influence on cell apoptosis. Moreover, liquiritigenin remarkably reduced the expression of runt-related transcription factor 2 (Runx2) in HCT116 cells...
February 22, 2018: Oncology Research
https://www.readbyqxmd.com/read/29471858/tumor-promoting-properties-of-mir-8084-in-breast-cancer-through-enhancing-proliferation-suppressing-apoptosis-and-inducing-epithelial-mesenchymal-transition
#9
Yujing Gao, Hongning Ma, Chanchan Gao, Ye Lv, XueHua Chen, Rongrong Xu, Miao Sun, Xinrui Liu, Xiaohong Lu, Xiuying Pei, Pu Li
BACKGROUND: Breast cancer is one of the most frequent malignancies and the second leading cause of cancer-related mortality in women. MicroRNAs play a key role in breast cancer development and progression. microRNA(miR)-8084 has been observed an aberrant expression in breast cancer. However, the functions and regulatory axes of miR-8084, particularly in breast cancer, were not entirely clear. METHODS: miR-8084 expression in breast cancer were investigated in a GEO dataset by in silico analysis and in 42 paired tumor tissues by qPCR...
February 23, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29471502/elevated-g6pd-expression-contributes-to-migration-and-invasion-of-hepatocellular-carcinoma-cells-by-inducing-epithelial-mesenchymal-transition
#10
Ming Lu, Lu Lu, Qiongzhu Dong, Guangyang Yu, Jinhong Chen, Lunxiu Qin, Lianxin Wang, Wenwei Zhu, Huliang Jia
Altered metabolism is one of the hallmarks of cancer cells. Pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism. Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the PPP, is elevated in many cancers and contributes to tumor growth by producing ribose-5-phosphate and NADPH through PPP. However, the role of G6PD in hepatocellular carcinoma (HCC) metastasis and the clinical significance of G6PD in HCC progression and prognosis have not been well determined. In this study, by investigating tissue samples from HCC patients and HCC cell lines, we found that elevated G6PD expression is significantly associated with HCC metastasis and poor prognosis of HCCs, and that knockdown of G6PD inhibits in vitro proliferation, migration and invasion of HCC cell lines...
February 17, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29471243/trps1-suppresses-breast-cancer-epithelial-mesenchymal-transition-program-as-a-negative-regulator-of-suz12
#11
Jing Hu, Peng Su, Meng Jiao, Xinnuo Bai, Mei Qi, Hui Liu, Zhen Wu, Jingtian Sun, Gengyin Zhou, Bo Han
Breast cancer (BC) is among the most common malignant diseases and metastasis is the handcuff of treatment. Cancer metastasis is a multistep process associated with the epithelial-mesenchymal transition (EMT) program. Several studies have demonstrated that transcriptional repressor GATA binding 1 (TRPS1) played important roles in development and progression of primary BC. In this study we sought to identify the mechanisms responsible for this function of TRPS1 in the continuum of the metastatic cascade. Here we described that TRPS1 was significantly associated with BC metastasis using public assessable datasets...
February 19, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29471141/the-morphological-and-molecular-mechanisms-of-epithelial-endothelial-to-mesenchymal-transition-and-its-involvement-in-atherosclerosis
#12
REVIEW
M Wesseling, T R Sakkers, S C A de Jager, G Pasterkamp, M J Goumans
Cell transdifferentiation occurs during cardiovascular development or remodeling either as a pathologic feature in the progression of disease or as a response to injury. Endothelial-to-Mesenchymal Transition (EndMT) is a process that is classified as a specialized form of Epithelial-to-Mesenchymal Transition (EMT), in which epithelial cells lose their epithelial characteristics and gain a mesenchymal phenotype. During transdifferentiation, cells lose both cell-cell contacts and their attachment to the basement membrane...
February 19, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29471038/co-delivery-nanoparticle-to-overcome-metastasis-promoted-by-insufficient-chemotherapy
#13
Qing Zhou, Yihui Li, Yanhong Zhu, Chan Yu, Haibo Jia, Binghao Bao, Hang Hu, Chen Xiao, Jianqi Zhang, Xiaofan Zeng, Ying Wan, Huibi Xu, Zifu Li, Xiangliang Yang
Heterogeneous distribution of drug inside tumor is ubiquitous, causing regional insufficient chemotherapy, which might be the hotbed for drug resistance, tumor cell repopulation and metastasis. Herein, we verify, for the first time, that heterogeneous drug distribution induced insufficient chemotherapy would accelerate the process of epithelial mesenchymal transition (EMT), consequently resulting in the promotion of tumor metastasis. To eliminate the insufficient chemotherapy promoted metastasis, we conceived a co-delivery strategy by hydroxyethyl starch-polylactide (HES-PLA) nanoparticle, in which DOX and TGF-β receptor inhibitor, LY2157299 (LY), were administered together...
February 19, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29471001/activated-cxcl5-cxcr2-axis-promotes-the-migration-invasion-and-emt-of-papillary-thyroid-carcinoma-cells-via-modulation-of-%C3%AE-catenin-pathway
#14
Dong Cui, Yongfu Zhao, Jingchao Xu
Initiation of epithelial-to-mesenchymal transition (EMT) is common in papillary thyroid carcinoma (PTC) and may contribute to its metastasis. Aims of the present study are to investigate whether and how the C-X-C motif chemokine ligand (CXCL)-5/C-X-C motif receptor 2 (CXCR2) axis affects PTC metastasis, with a focus on the EMT process. Herein, two PTC cell lines, KTC-1 and B-CPAP cells, identified as CXCR2-positive cells were used as the cell model. We found that a 24-h stimulation of 1 or 10 nM recombinant human CXCL5 (rhCXCL5) enhanced the migration and invasion of both KTC-1 and B-CPAP cells without affecting their proliferation...
February 19, 2018: Biochimie
https://www.readbyqxmd.com/read/29469819/the-long-noncoding-rna-hotair-in-breast-cancer-does-autophagy-play-a-role
#15
Elżbieta Pawłowska, Joanna Szczepanska, Janusz Blasiak
HOTAIR (HOX transcript antisense RNA) plays a critical role in chromatin dynamics through the interaction with histone modifiers resulting in transcriptional gene silencing. The promoter of the HOTAIR gene contains multiple estrogen response elements (EREs) and is transcriptionally activated by estradiol in estrogen receptor-positive breast cancer cells. HOTAIR competes with BRCA1, a critical protein in breast cancer and is a critical regulator of genes involved in epithelial-to-mesenchymal transition. It mediates an oncogenic action of c-Myc, essential for breast carcinogenesis...
November 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29469614/tgf-%C3%AE-1-induced-deposition-of-provisional-extracellular-matrix-by-tracheal-basal-cells-promotes-epithelial-to-mesenchymal-transition-in-a-jnk1-dependent-manner
#16
Jos L van der Velden, Darcy E Wagner, Karolyn G Lahue, Sarah T Abdalla, Ying W Lam, Daniel J Weiss, Yvonne M W Janssen-Heininger
Epithelial cells have been suggested as potential drivers of lung fibrosis, although the epithelial-dependent pathways that promote fibrogenesis remain unknown. Extracellular matrix is increasingly recognized as an environment that can drive cellular responses in various pulmonary diseases. In this study, we demonstrate that transforming growth factor- beta (TGF-β1)-stimulated mouse tracheal basal (MTB) cells produce provisional matrix proteins in vitro, which initiate mesenchymal changes in subsequently freshly plated MTB cells via Rho kinase- and c-Jun-N-terminal kinase (JNK1)-dependent processes...
February 22, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29468299/smad4-and-epithelial-mesenchymal-transition-proteins-in-colorectal-carcinoma-an-immunohistochemical-study
#17
M Ioannou, E Kouvaras, R Papamichali, M Samara, I Chiotoglou, G Koukoulis
Epithelial-mesenchymal transition (EMT) plays an important role in cancer metastasis. During EMT, tumor cells acquire the capacity to migrate and invade the stroma. Activation of the transforming growth factor-b (TGF-b) signaling pathway is of major importance for the initiation of EMT. Smad4, an essential protein of this pathway, is known to complex with multiple transcription factors (e.g. Snail-1, Slug, Twist-1), in various types of cancer, promoting the repression or activation of target genes. The role of Smad4 in colorectal cancer (CRC) is not straightforward so far...
February 21, 2018: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29467947/metformin-inhibits-tgf-%C3%AE-1-induced-epithelial-to-mesenchymal-transition-like-process-and-stem-like-properties-in-gbm-via-akt-mtor-zeb1-pathway
#18
Yang Song, Yong Chen, Yunqian Li, Xiaoyan Lyu, Jiayue Cui, Ye Cheng, Liyan Zhao, Gang Zhao
Glioblastoma (GBM) is the most frequent and aggressive brain tumor in adults. In spite of advances in diagnosis and therapy, the prognosis is still relatively poor. The invasive property of GBM is the major cause of death in patients. Epithelial-to-mesenchymal transition-like process (EMT-like process) is considered to play an important role in the invasive property. Metformin has been reported as a regulator of EMT-like process. In this study, we confirmed that metformin inhibited TGF-β1-induced EMT-like process and EMT-associated migration and invasion in LN18 and U87 GBM cells...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29467938/smad4-independent-activation-of-tgf-%C3%AE-signaling-by-muc1-in-a-human-pancreatic-cancer-cell-line
#19
Priyanka Grover, Sritama Nath, Monica D Nye, Ru Zhou, Mohammad Ahmad, Pinku Mukherjee
Pancreatic Ductal Adenocarcinoma (PDA) has a mortality rate that nearly matches its incidence rate. Transforming Growth Factor Beta (TGF-β) is a cytokine with a dual role in tumor development switching from a tumor suppressor to a tumor promoter. There is limited knowledge of how TGF-β function switches during tumorigenesis. Mucin 1 (MUC1) is an aberrantly glycosylated, membrane-bound, glycoprotein that is overexpressed in >80% of PDA cases and is associated with poor prognosis. In PDA, MUC1 promotes tumor progression and metastasis via signaling through its cytoplasmic tail (MUC1-CT) and interacting with other oncogenic signaling molecules...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29467936/dynamic-changes-in-cd44v-positive-cells-after-preoperative-anti-her2-therapy-and-its-correlation-with-pathologic-complete-response-in-her2-positive-breast-cancer
#20
Teruo Yamauchi, Jose Rodrigo Espinosa Fernandez, Chiyo K Imamura, Hideko Yamauchi, Hiromitsu Jinno, Maiko Takahashi, Yuko Kitagawa, Seigo Nakamura, Bora Lim, Savitri Krishnamurthy, James M Reuben, Diane Liu, Debasish Tripathy, Helen Chen, Naoko Takebe, Hideyuki Saya, Naoto T Ueno
Chemotherapy has been reported to increase the proportion of cancer stem cells (CSCs) and to promote epithelial-mesenchymal transition (EMT) phenotype changes. Anti-HER2 therapy may provide a strategy for eliminating CSC and EMT, which contribute to therapeutic resistance. No study has determined the changes in the quantity or characteristics of CSCs or circulating tumor cells (CTCs) with EMT phenotype during preoperative anti-HER2 therapy, and whether these changes correlate to response to dual anti-HER2 therapy...
January 23, 2018: Oncotarget
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