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https://www.readbyqxmd.com/read/29435274/topical-5-potassium-permanganate-solution-accelerates-the-healing-process-in-chronic-diabetic-foot-ulcers
#1
Iván Delgado-Enciso, Violeta M Madrigal-Perez, Agustin Lara-Esqueda, Martha G Diaz-Sanchez, Jose Guzman-Esquivel, Luis E Rosas-Vizcaino, Oscar O Virgen-Jimenez, Juleny Kleiman-Trujillo, Maria R Lagarda-Canales, Gabriel Ceja-Espiritu, Viridiana Rangel-Salgado, Uriel A Lopez-Lemus, Josuel Delgado-Enciso, Agustin D Lara-Basulto, Alejandro D Soriano Hernández
Potassium permanganate has been reported to be an effective treatment for certain types of wounds. The aim of the present study was to evaluate the use of potassium permanganate in the treatment of diabetic foot ulcers. A single-blind, randomized, controlled clinical trial was conducted on patients with type 2 diabetes mellitus that presented with a foot ulcer persisting for >3 months. The control group (n=10) was treated with the current standard treatment, which comprises of measures for reducing pressure in the ulcerated area, daily cleansing of the ulcer with potable water and antiseptic wash solution, and the application of a disinfectant solution on the entire surface area of the ulcer; while the intervention group (n=15) received the standard treatment plus 5% topical potassium permanganate solution applied once a day for 21 days...
February 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29413769/does-thromboprophylaxis-reduce-symptomatic-venous-thromboembolism-in-patients-with-below-knee-cast-treatment-for-foot-and-ankle-trauma-a-systematic-review-and-meta-analysis
#2
REVIEW
Ben A Hickey, Ultan Watson, Andrew Cleves, Raza Alikhan, Neil Pugh, Len Nokes, Anthony Perera
BACKGROUND: Our aim was to determine the evidence for thromboprophylaxis for prevention of symptomatic venous thromboembolism (VTE) in adults with foot or ankle trauma treated with below knee cast or splint. Our secondary aim was to report major bleeding events. METHODS: MEDLINE and EMBASE databases were searched for randomized controlled trials from inception to 1st June 2015. RESULTS: Seven studies were included. All focused on low molecular weight heparin (LMWH)...
February 2018: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29410159/sinus-tarsi-approach-sta-versus-extensile-lateral-approach-ela-for-treatment-of-closed-displaced-intra-articular-calcaneal-fractures-diacf-a-meta-analysis
#3
REVIEW
L Bai, Y Hou, G-H Lin, X Zhang, G-Q Liu, B Yu
INTRODUCTION: Our aim was to compare the effect of Sinus Tarsi Approach (STA) vs Extensile Lateral Approach(ELA) for Treatment of Closed Displaced Intra-Articular Calcaneal Fractures (DIACF.) is still being debated, MATERIALS AND METHODS: A thorough research was carried out in the MEDLINE, EMBASE, and Cochrane library databases from inception to December 2016. Only prospective or retrospective comparative studies was selected in this meta-analysis. Two independent reviewers conducted literature search, data extraction, and quality assessment...
February 1, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29409199/treatment-of-first-metatarsophalangeal-joint-arthritis-using-hemiarthroplasty-with-a-synthetic-cartilage-implant-or-arthrodesis-a-comparison-of-operative-and-recovery-time
#4
Mark Glazebrook, Alastair S E Younger, Timothy R Daniels, Dishan Singh, Chris Blundell, Gwyneth de Vries, Ian L D Le, Dominic Nielsen, M Elizabeth Pedersen, Anthony Sakellariou, Matthew Solan, Guy Wansbrough, Judith F Baumhauer
BACKGROUND: First metatarsophalangeal joint (MTPJ1) hemiarthroplasty using a novel synthetic cartilage implant was as effective and safe as MTPJ1 arthrodesis in a randomized clinical trial. We retrospectively evaluated operative time and recovery period for implant hemiarthroplasty (n=152) and MTPJ1 arthrodesis (n=50). METHODS: Perioperative data were assessed for operative and anaesthesia times. Recovery and return to function were prospectively assessed with the Foot and Ankle Ability Measure (FAAM) Sports and Activities of Daily Living (ADL) subscales and SF-36 Physical Functioning (PF) subscore...
May 29, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29408453/a-randomized-control-trial-to-establish-the-feasibility-and-safety-of-rapamycin-treatment-in-an-older-human-cohort-immunological-physical-performance-and-cognitive-effects
#5
Ellen Kraig, Leslie A Linehan, Hanyu Liang, Terry Q Romo, Qianqian Liu, Yubo Wu, Adriana D Benavides, Tyler J Curiel, Martin A Javors, Nicolas Musi, Laura Chiodo, Wouter Koek, Jonathan A L Gelfond, Dean L Kellogg
Inhibition of the mechanistic target of rapamycin (mTOR) pathway by rapamycin (RAPA), an FDA-approved immunosuppressive drug used as a clinical therapy to prevent solid organ allograft rejection, enhances longevity in mice. Importantly, RAPA was efficacious even when initiated in relatively old animals, suggesting that mTOR inhibition could potentially slow the progression of aging-associated pathologies in older humans (Harrison et al., 2009; Miller et al., 2011). However, the safety and tolerability of RAPA in older human subjects have not yet been demonstrated...
February 3, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29390881/efficacy-of-cellular-therapy-for-diabetic-foot-ulcer-a-meta-analysis-of-randomized-controlled-clinical-trials
#6
Ye Zhang, Hong Deng, Zhouping Tang
Diabetes mellitus is a widely spread chronic disease with growing incidence worldwide, and diabetic foot ulcer is one of the most serious complications of diabetes. Cellular therapy has shown promise in the management of diabetic foot ulcer in many preclinical experiments and clinical researches. Here, we performed a meta-analysis to evaluate the efficacy and safety of cellular therapy in the management of diabetic foot ulcer. We systematically searched PubMed, MEDLINE, EMBASE, and Cochrane Library databases from inception to May 2017 for randomized controlled trials assessing the efficacy of cellular therapy in diabetic foot ulcer, and a meta-analysis was conducted...
December 2017: Cell Transplantation
https://www.readbyqxmd.com/read/29377202/update-on-management-of-diabetic-foot-ulcers
#7
REVIEW
Estelle Everett, Nestoras Mathioudakis
Diabetic foot ulcers (DFUs) are a serious complication of diabetes that results in significant morbidity and mortality. Mortality rates associated with the development of a DFU are estimated to be 5% in the first 12 months, and 5-year morality rates have been estimated at 42%. The standard practices in DFU management include surgical debridement, dressings to facilitate a moist wound environment and exudate control, wound off-loading, vascular assessment, and infection and glycemic control. These practices are best coordinated by a multidisciplinary diabetic foot wound clinic...
January 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29374988/the-effects-of-timing-of-ankle-blocks-in-forefoot-midfoot-or-hindfoot-reconstruction-with-the-use-of-an-ankle-tourniquet
#8
James Gwosdz, Lattisha Bilbrew, Daniel Jupiter, Vinod Panchbhavi
BACKGROUND: Ankle blocks are used in the ambulatory surgery setting to control postoperative pain, which is often worst in the first 24 hours after surgery. We conducted a trial to determine whether the timing of ankle block administration in relation to ankle tourniquet inflation has an effect on perceived pain and narcotic consumption. METHODS: A prospective randomized study was conducted between August 2015 and January 2016. Patients were assigned to three groups...
January 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29368539/safety-and-efficacy-of-ads-5102-amantadine-extended-release-capsules-to-improve-walking-in-multiple-sclerosis-a-randomized-placebo-controlled-phase-2-trial
#9
Jeffrey A Cohen, Samuel F Hunter, Theodore R Brown, Mark Gudesblatt, Ben W Thrower, Lily Llorens, Cindy J Souza-Prien, April E Ruby, David N Chernoff, Rajiv Patni
BACKGROUND: Walking impairment causes disability and reduced quality of life in patients with multiple sclerosis (MS). OBJECTIVE: Characterize the safety and efficacy of ADS-5102 (amantadine) extended release capsules, 274 mg administered once daily at bedtime in patients with MS with walking impairment. METHODS: This randomized, double-blind, placebo-controlled, 4-week study was conducted at 14 trial sites in the United States. Study objectives included safety and tolerability of ADS-5102, and efficacy assessments (Timed 25-Foot Walk (T25FW), Timed Up and Go (TUG), 2-Minute Walk Test, and Multiple Sclerosis Walking Scale-12)...
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29366905/hand-dysfunction-in-type-2-diabetes-mellitus-systematic-review-with-meta-analysis
#10
REVIEW
Shubha Gundmi, Arun G Maiya, Anil K Bhat, N Ravishankar, Manjunatha H Hande, K V Rajagopal
BACKGROUND: People with type 2 diabetes mellitus frequently show complications in feet and hands. However, the literature has mostly focused on foot complications. The disease can affect the strength and dexterity of the hands, thereby reducing function. OBJECTIVES: This systematic review and meta-analysis focused on identifying the existing evidence on how type 2 diabetes mellitus affects hand strength, dexterity and function. METHODS: We searched MEDLINE via PubMed, CINHAL, Scopus and Web of Science, and the Cochrane central register of controlled trials for reports of studies of grip and pinch strength as well as hand dexterity and function evaluated by questionnaires comparing patients with type 2 diabetes mellitus and healthy controls that were published between 1990 and 2017...
January 27, 2018: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29364026/effects-of-a-4-week-intrinsic-foot-muscle-exercise-program-on-motor-function-a-preliminary-randomized-control-trial
#11
John J Fraser, Jay Hertel
CONTEXT: Intrinsic foot muscle (IFM) exercises are utilized clinically in the treatment of foot and ankle conditions. However, the effectiveness of training on IFM motor function is unknown. OBJECTIVE: To study the effects of a 4-week IFM exercise program on motor function, perceived difficulty, and IFM motor activation measured using ultrasound imaging (USI) during three IFM exercises. DESIGN: Single-blinded randomized control trial. SETTING: Laboratory...
January 24, 2018: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/29353870/efficiency-of-stem-cell-based-therapy-in-the-treatment-of-diabetic-foot-ulcer-a-meta-analysis
#12
Xuan Shu, Shenyou Shu, Shijie Tang, Lvjun Yang, Dan Liu, Ke Li, Zejun Dong, Zhongchao Ma, Zhensen Zhu, Jialong Din
Diabetic foot ulcer is a chronic, refractory, frequent complication in diabetic patient. Its treatment often requires multidisciplinary joint efforts, diverse strategies have been adopted to address this annoying issue, including stem cell-based therapy/acellular dermal matrix/negative pressure wound therapy etc. However, consensus has not been reached. To assess the current evidence regarding the efficiency and potential advantages of stem cell-based therapy compared with conventional standard treatment and/or placebo in the treatment of diabetic foot ulcer...
January 22, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29346146/use-of-oxidized-regenerated-cellulose-collagen-matrix-in-chronic-diabetic-foot-ulcers-a-systematic-review
#13
Gisele Chicone, Viviane Fernandes de Carvalho, André Oliveira Paggiaro
OBJECTIVE: Diabetic wounds that do not heal completely usually exhibit inflammatory markers, increased protease activity, and reduced levels of growth factors and cell count. A systematic review was performed to determine whether there is enough evidence to support the use of an oxidized regenerated cellulose/collagen matrix (ORC+C) to treat diabetic foot ulcers (DFUs). METHODS: Study authors analyzed randomized controlled trials (RCTs) on ORC+C dressings for the treatment of DFUs...
February 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29340317/intradialytic-cognitive-and-exercise-training-may-preserve-cognitive-function
#14
Mara A McAdams-DeMarco, Jonathan Konel, Fatima Warsame, Hao Ying, Marlís González Fernández, Michelle C Carlson, Derek M Fine, Lawrence J Appel, Dorry L Segev
Introduction: Cognitive decline is common and increases mortality risk in hemodialysis patients. Intradialytic interventions like cognitive training (CT) and exercise training (ET) may preserve cognitive function. Methods: We conducted a pilot randomized controlled trial of 20 hemodialysis patients to study the impact of 3 months of intradialytic CT (tablet-based brain games) (n = 7), ET (foot peddlers) (n = 6), or standard of care (SC) (n = 7) on cognitive function...
January 2018: KI Reports
https://www.readbyqxmd.com/read/29337175/minimally-invasive-versus-extensile-lateral-approach-for-sanders-type-ii-and-iii-calcaneal-fractures-a-meta-analysis-of-randomized-controlled-trials
#15
REVIEW
Zhikui Zeng, Lingmei Yuan, Shengpeng Zheng, Youqiang Sun, Feng Huang
BACKGROUND: The use of less-invasive techniques in the treatment of displaced intra-articular calcaneal fractures (DIACFs) remains controversial. No prior meta-analysis has considered the influence of differences in the fracture type. Thus, our meta-analysis aimed to investigate the efficacy and safety of minimally invasive (MI) in Sanders type II and III fractures. MATERIALS AND METHODS: A comprehensive search was performed to identify RCTs comparing MI using sinus tarsi approach (STA) or percutaneous reduction (PR) to open reduction (OR) via extensile lateral approach (ELA) from the Cochrane Library, PubMed, Embase and CNKI...
January 11, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29336265/efficacy-of-aloe-vera-plantago-major-gel-in-diabetic-foot-ulcer-a-randomized-double-blind-clinical-trial
#16
Younes Najafian, Zahra Mazloum, Mona Najaf Najafi, Shokouhsadat Hamedi, Marjan Mahjour, Zohre Feyzabadi
BACKGROUND: Diabetic foot ulcer (DFU) is one of the most common complications of diabetic patients. Mostly, non-healing DFU leads to infection, gangrene, amputation and even death. High costs and poor healing of the wounds need a new treatment such as alternative medicine. So, the aim of this study was to evaluate the efficacy of Aloe vera/ Plantago major gel (Plantavera gel) in healing of DFU. METHODS: Forty patients with DFU enrolled in a double-blind randomized clinical trial...
January 14, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29329555/exercise-during-and-after-neoadjuvant-rectal-cancer-treatment-the-exert-trial-study-protocol-for-a-randomized-controlled-trial
#17
Andria R Morielli, Nawaid Usmani, Normand G Boulé, Diane Severin, Keith Tankel, Tirath Nijjar, Kurian Joseph, Alysa Fairchild, Kerry S Courneya
BACKGROUND: Standard treatment for locally advanced rectal cancer includes 5-6 weeks of neoadjuvant chemoradiotherapy (NACRT) followed by total mesorectal excision 6-8 weeks later. NACRT improves local disease control and surgical outcomes but also causes side effects including fatigue, diarrhea, hand-foot syndrome, and physical deconditioning that may impede quality of life (QoL), treatment completion, treatment response, and long-term prognosis. Interventions to improve treatment outcomes and manage side effects that are safe, tolerable and low-cost are highly desirable...
January 12, 2018: Trials
https://www.readbyqxmd.com/read/29327602/combination-therapy-versus-exercise-and-orthotic-support-in-the-management-of-pain-in-plantar-fasciitis-a-randomized-controlled-trial
#18
Eda Cinar, Shikha Saxena, Fatma Uygur
BACKGROUND: This study aimed at estimating the effectiveness of two commonly used modalities-extracorporeal shock wave therapy (ESWT) and low-level laser therapy (LLLT)-each combined with usual care (exercises and orthotic supports) in comparison to only usual care to relieve pain in patients with plantar fasciitis (PF). METHODS: Participants with PF were randomly allocated into 3 groups: ESWT (n = 25), LLLT (n = 24), and control (n = 17). All participants received a home exercise program with orthotic support...
January 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29297260/light-rhythmic-exercise-with-dietary-milk-fat-globule-membrane-improves-physical-fitness-in-an-elderly-japanese-population-a-double-blind-randomized-placebo-controlled-trial
#19
Yasuko Yoshinaka, Satoko Soga, Noriyasu Ota, Keiichi Yokoyama, Yosuke Yamada, Misaka Kimura
This study aimed to investigate the efficacy of home-based, light gymnastic exercise plus dietary milk fat globule membrane (MFGM) intake on physical fitness of an elderly Japanese sample in a pilot, double-blind, randomized, placebo-controlled trial. Seventy-one subjects (male, n = 13; female, n = 58) were randomly assigned into two groups: placebo (n = 35 [male, n = 6; female, n = 29]) and MFGM group (n = 36 [male, n = 7; female, n = 29]). The intervention was eight weeks. Subjects ingested either MFGM (1 g/day) or placebo tablets daily and engaged in an exercise program daily...
January 3, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29289541/supervised-balance-training-and-wii-fit-based-exercises-lower-falls-risk-in-older-adults-with-type-2-diabetes
#20
Steven Morrison, Rachel Simmons, Sheri R Colberg, Henri K Parson, Aaron I Vinik
OBJECTIVES: This study examined the benefits of and differences between 12 weeks of thrice-weekly supervised balance training and an unsupervised at-home balance activity (using the Nintendo Wii Fit) for improving balance and reaction time and lowering falls risk in older individuals with type 2 diabetes mellitus (T2DM). DESIGN: Before-after trial. SETTING: University research laboratory, home environment. PARTICIPANTS: Sixty-five older adults with type 2 diabetes were recruited for this study...
December 27, 2017: Journal of the American Medical Directors Association
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