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Charles Raybaud
PURPOSE: The aims of this study are to analyze how the nature and the behavior of low-grade glial tumors (LGGT) in children may correlate with the anatomy of the cerebral hemispheres and to evaluate the consequent impact of diffusion tensor imaging (DTI) techniques in the presurgical assessment. METHODS: This is a combined review of a series of 155 cases of LGGT and of the recent literature on the subject. RESULTS: The cases retrieved from our data bank were divided in central hemispheric tumors (basal ganglia and thalami) (36 cases), glioneuronal cortical-based tumors (49 cases), and glial tumors of the cerebral mantle (70 cases)...
October 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Julia M Young, Benjamin R Morgan, Hilary E A Whyte, Wayne Lee, Mary Lou Smith, Charles Raybaud, Manohar M Shroff, John G Sled, Margot J Taylor
Identifying trajectories of early white matter development is important for understanding atypical brain development and impaired functional outcomes in children born very preterm (<32 weeks gestational age [GA]). In this study, 161 diffusion images were acquired in children born very preterm (median GA: 29 weeks) shortly following birth (75), term-equivalent (39), 2 years (18), and 4 years of age (29). Diffusion tensors were computed to obtain measures of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD), which were aligned and averaged...
September 6, 2016: Cerebral Cortex
Andrea Poretti, Ramy Ashmawy, Tomas Garzon-Muvdi, George I Jallo, Thierry A G M Huisman, Charles Raybaud
Our understanding of cerebellar tonsillar herniation evolved over time and nowadays various pathomechanisms have been proposed. Causes of tonsillar herniation share a discrepancy between content (fore- and hindbrain) and container (supratentorial cranial vault, posterior fossa), may be associated with abnormalities of the craniocervical junction, and may have a developmental or acquired nature. In tonsillar herniation, the hindbrain is not malformed but deformed. Accordingly, "Chiari type 1 deformity," not "Chiari type 1 malformation" is the correct term to characterize primary tonsillar herniation...
October 2016: Neuropediatrics
Yordan Benhamou, Vincent Picco, Hélène Raybaud, Anne Sudaka, Emmanuel Chamorey, Sanja Brolih, Martino Monteverde, Marco Merlano, Cristiana Lo Nigro, Damien Ambrosetti, Gilles Pagès
Oral Squamous Cell Carcinoma (OSCC) is the most common oral cancer worldwide. Treatments including surgery, radio- and chemo-therapies mostly result in debilitating side effects. Thus, a more accurate evaluation of patients at risk of recurrence after radio/chemo treatment is important for preserving their quality of life. We assessed whether the Telomeric Repeat-binding Factor 2 (TERF2) influences tumor aggressiveness and treatment response. TERF2 is over-expressed in many cancers but its correlation to patient outcome remains controversial in OSCC...
June 14, 2016: Oncotarget
J-P Hammelin, G Cardon, M Reberolle, F Moulonguet, Y Neugebauer, G Raybaud, V Gnemmi, E Hachulla
INTRODUCTION: AA amyloidosis is a common but severe complication of many chronic inflammatory processes of infectious, autoimmune, or neoplastic origin. It frequently leads to renal damage, often presenting as a nephrotic syndrome. Giant cell arteritis is a common inflammatory arteritis in elderly people, but rarely complicated by AA amyloidosis. CASE REPORT: We report an 87-year-old female who presented with a nephrotic syndrome and a chronic inflammation, in whom the kidney biopsy showed secondary amyloidosis...
May 27, 2016: La Revue de Médecine Interne
Charles Raybaud
No abstract text is available yet for this article.
July 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
M Gerin, G Jambon, A Fouque-Aubert, C Raybaud, P Cochat, O Claris, J Bacchetta
BACKGROUND: Bisphosphonates (BP) are sometimes used in children and young women, but their use requires expertise and caution due to the relative lack of long-term efficacy and safety data. CLINICAL CASES: We report on two dizygotic male twins with a past of mild prematurity who presented at the age of 2 months with moderate clinical craniotabes, hypophosphatemia, normal circulating calcium, severe hypercalciuria, and low parathyroid hormone levels. Following supplementation with oral phosphorus and native vitamin D, the clinical and biological abnormalities disappeared within 2 months...
September 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Julia Pavaine, Julia M Young, Benjamin R Morgan, Manohar Shroff, Charles Raybaud, Margot J Taylor
INTRODUCTION: The purpose of this study was to assess the impact of brain injury on white matter development and long-term outcomes in very preterm (VPT) neonates. METHODS: Eighty-five VPT neonates (born <32/40 weeks gestational age (GA)) scanned within 2 weeks of birth were divided into three groups based on the presence of perinatal cerebral injury: (i) no injury, (ii) mild/moderate injury and (iii) severe injury. Diffusion tensor imaging (DTI) was acquired for each neonate and fractional anisotropy (FA), and diffusivity measures were calculated in the posterior limb of the internal capsule (PLIC) and optic radiation (OR)...
March 2016: Neuroradiology
Aqeela H Al-Hashim, Susan Blaser, Charles Raybaud, Daune MacGregor
AIM: To study neuroradiological features in pediatric patients with corpus callosum abnormalities, using new functional subtyping for the corpus callosum, and to correlate the features with the clinical presentation. METHOD: We performed a retrospective review of 125 patients with radiologically identified abnormalities of the corpus callosum seen between 1999 and 2012. The study reviewed clinical features, genetic etiology, and chromosomal microarray (CMA) results...
May 2016: Developmental Medicine and Child Neurology
Wayne Lee, Hisham Al-Dossary, Charles Raybaud, Julia M Young, Benjamin R Morgan, Hilary E A Whyte, John G Sled, Margot J Taylor, Manohar M Shroff
PURPOSE: To measure cerebellar growth in a longitudinal cohort of very preterm infants to identify early predictors of subsequent brain growth. Although the cerebellum grows rapidly during late gestation, the rate and variability of growth following premature birth, and the effects of associated injury, are largely unknown. MATERIALS AND METHODS: In all, 105 very-preterm born infants (24-32 weeks GA) were imaged using magnetic resonance imaging (MRI) at birth, term-equivalent, 2, and 4 years of age...
June 2016: Journal of Magnetic Resonance Imaging: JMRI
Charles Raybaud, Vijay Ramaswamy, Michael D Taylor, Suzanne Laughlin
INTRODUCTION: Modern understanding of the relation between the mutated cancer stem cell and its site of origin and of its interaction with the tissue environment is enhancing the importance of developmental anatomy in the diagnostic assessment of posterior fossa tumors in children. The aim of this review is to show how MR imaging can improve on the exact identification of the tumors in the brainstem and in the vicinity of the fourth ventricle in children, using both structural imaging data and a precise topographical assessment guided by the developmental anatomy...
October 2015: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Charles Raybaud
PURPOSE: This study was conducted to design a rational approach to the MR diagnosis of hydrocephalus based on a pathophysiologic reevaluation of its possible mechanisms and to apply it to the different etiological contexts. METHOD: A review of the literature reports describing new physiologic models of production and absorption and of the hydrodynamics of the CSF was made. RESULTS: Besides the secretion of CSF by the choroid plexuses, and its passive, pressure-dependent transdural absorption (arachnoid villi, dural clefts, cranial, and spinal nerve sheaths), water transporters, aquaporins, allow water (if not ions and organic molecules) to exchange freely between the brain parenchyma and the CSF spaces across the ependymal and the pial interfaces (including the Virchow-Robin spaces)...
January 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Maxence Valla, Aaron J Rossini, Maxime Caillot, Céline Chizallet, Pascal Raybaud, Mathieu Digne, Alexandra Chaumonnot, Anne Lesage, Lyndon Emsley, Jeroen A van Bokhoven, Christophe Copéret
Despite the widespread use of amorphous aluminosilicates (ASA) in various industrial catalysts, the nature of the interface between silica and alumina and the atomic structure of the catalytically active sites are still subject to debate. Here, by the use of dynamic nuclear polarization surface enhanced NMR spectroscopy (DNP SENS) and density functional theory (DFT) calculations, we show that on silica and alumina surfaces, molecular aluminum and silicon precursors are, respectively, preferentially grafted on sites that enable the formation of Al(IV) and Si(IV) interfacial sites...
August 26, 2015: Journal of the American Chemical Society
Kim Larmier, Céline Chizallet, Pascal Raybaud
Controlling the nature and size of cobalt(II) polynuclear precursors on γ-alumina and silica-alumina supports represents a challenge for the synthesis of optimal cobalt-based heterogeneous catalysts. By density functional theory (DFT) calculations, we show how after drying the interaction of cobalt(II) precursor on γ-alumina is driven by a structural recognition phenomenon, leading to the formation of an epitaxial Co(OH)2 precipitate involving a Co-Al hydrotalcite-like interface. On a silica-alumina surface, this phenomenon is prevented due to the passivation effect of silica domains...
June 1, 2015: Angewandte Chemie
E Widjaja, M Zamyadi, C Raybaud, O C Snead, S M Doesburg, M L Smith
BACKGROUND AND PURPOSE: Structural connectivity has been thought to be a less sensitive measure of network changes relative to functional connectivity in children with localization-related epilepsy. The aims of this study were to investigate the structural networks in children with localization-related epilepsy and to assess the relation among structural connectivity, intelligence quotient, and clinical parameters. MATERIALS AND METHODS: Forty-five children with nonlesional localization-related epilepsy and 28 healthy controls underwent DTI...
July 2015: AJNR. American Journal of Neuroradiology
Revital Nossin-Manor, Dallas Card, Charles Raybaud, Margot J Taylor, John G Sled
The magnetization transfer ratio (MTR) and diffusion tensor imaging (DTI) correlates of early brain development were examined in cohort of 18 very preterm neonates (27-31 gestational weeks) presenting with normal radiological findings scanned within 2weeks after birth (28-32 gestational weeks). A combination of non-linear image registration, tissue segmentation, and voxel-wise regression was used to map the age dependent changes in MTR and DTI-derived parameters in 3D across the brain based on the cross-sectional in vivo preterm data...
May 15, 2015: NeuroImage
R Shayna Rosenbaum, Fuqiang Gao, Kie Honjo, Charles Raybaud, Rosanna K Olsen, Daniela J Palombo, Brian Levine, Sandra E Black
Individuals with developmental amnesia experience compromised development of episodic memory for details of personal life events, believed to relate to changes to the hippocampus after birth. Here we report the very rare discovery of aplasia of the mammillary bodies, hypogenesis of the fornix, and abnormal hippocampal shape and orientation in H.C., a well-documented case of selectively compromised episodic memory development who is the subject of numerous published empirical articles. These anatomical abnormalities are highly suggestive of disrupted extended hippocampal system development very early in gestation, despite an original diagnosis of developmental amnesia and assumed perinatal hypoxia...
December 2014: Neuropsychologia
Marlou Raets, Jeroen Dudink, Charles Raybaud, Luca Ramenghi, Maarten Lequin, Paul Govaert
The brain veins of infants are in a complex phase of remodelling in the perinatal period. Magnetic resonance venography and susceptibility-weighted imaging, together with high-resolution Doppler ultrasound, have provided new tools to aid study of venous developmental anatomy and disease. This review aims to provide a comprehensive background of vein development and perinatal venous lesions in preterm and term-born infants, and to encourage further research in both the fetus and the newborn infant, with the aim of preventing or mitigating parenchymal injury related to diseases involving veins...
March 2015: Developmental Medicine and Child Neurology
Moussab Harb, Philippe Sautet, Ela Nurlaela, Pascal Raybaud, Luigi Cavallo, Kazunari Domen, Jean-Marie Basset, Kazuhiro Takanabe
Finding an ideal photocatalyst for achieving efficient overall water splitting still remains a great challenge. By applying accurate first-principles quantum calculations based on DFT with the screened non-local hybrid HSE06 functional, we bring rational insights at the atomic level into the influence of non-stoichiometric compositions on essential properties of tantalum (oxy)nitride compounds as visible-light-responsive photocatalysts for water splitting. Indeed, recent experiments show that such non-stoichiometry is inherent to the nitridation methods of tantalum oxide with unavoidable oxygen impurities...
October 14, 2014: Physical Chemistry Chemical Physics: PCCP
Agnes Gorczyca, Virginie Moizan, Celine Chizallet, Olivier Proux, William Del Net, Eric Lahera, Jean-Louis Hazemann, Pascal Raybaud, Yves Joly
Platinum nanoclusters highly dispersed on γ-alumina are widely used as heterogeneous catalysts. To understand the chemical interplay between the Pt nanoparticles, the support, and the reductive atmosphere, we performed X-ray absorption near edge structure (XANES) in situ experiments recorded in high energy resolution fluorescence detection (HERFD) mode. Spectra are assigned by comparison with simulated XANES spectra on models obtained by molecular dynamics (DFT-MD). We propose platinum cluster morphologies and quantify the hydrogen coverages compatible with XANES spectra recorded at variable hydrogen pressures and temperatures...
November 10, 2014: Angewandte Chemie
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