keyword
https://read.qxmd.com/read/38487339/onset-of-irritable-bowel-syndrome-dyspepsia-diarrhea-bloating-and-constipation-in-deployed-gulf-war-veterans
#21
JOURNAL ARTICLE
Zachary Thomas Verne, Jeremy Zachary Fields, George Nicholas Verne, Benjamin Buyi Zhang, Amber Leigh Thacker, QiQi Zhou
An estimated 694,550 United States service members were actively deployed to the Persian Gulf from 1990-1991. Many veterans who were deployed developed Persian Gulf War Syndrome along with chronic gastrointestinal symptoms after returning from the Persian Gulf. Our objective in this study was to determine the phenotypic expression of gastrointestinal symptom complexes in previously healthy veterans who had been stationed in the Persian Gulf. One hundred and four consecutive veterans (88 males, 16 females) who had previously been deployed in 1990-91 were evaluated for their bowel habits and gastrointestinal symptoms...
June 2024: Int J Gasteroenterol (N Y)
https://read.qxmd.com/read/38487112/general-population-awareness-of-primary-immune-deficiency-disease-in-children-in-the-arar-region-saudi-arabia
#22
JOURNAL ARTICLE
Safya E Esmaeel, Hassan T Mohamed, Reef A Alshammari, Israa S Alanazi, Naseem D Aleawaili, Fai S Alanazi
Background Primary immunodeficiency disorders (PIDD) are of various types and severities, and they are associated with a delay in diagnosis. Early diagnosis of PIDD helps to improve the quality of life of affected children and prevent permanent consequences such as organ damage. Hence, awareness of PIDD is a must in the community to aid in early detection. Objectives The study aims to investigate the general population's awareness of PIDD in children in Arar, Northern Saudi Arabia. Methods A cross-sectional design was utilized to determine the awareness of PIDD in children in Arar, Northern Saudi Arabia...
February 2024: Curēus
https://read.qxmd.com/read/38486305/italian-guidelines-for-the-management-of-irritable-bowel-syndrome-in-children-and-adolescents-joint-consensus-from-the-italian-societies-of-gastroenterology-hepatology-and-pediatric-nutrition-sigenp-pediatrics-sip-gastroenterology-and-endoscopy-sige-and-neurogastroenterology
#23
REVIEW
Giovanni Di Nardo, Giovanni Barbara, Osvaldo Borrelli, Cesare Cremon, Valentina Giorgio, Luigi Greco, Michele La Pietra, Giovanni Marasco, Licia Pensabene, Marisa Piccirillo, Claudio Romano, Silvia Salvatore, Michele Saviano, Vincenzo Stanghellini, Caterina Strisciuglio, Renato Tambucci, Rossella Turco, Letizia Zenzeri, Annamaria Staiano
The irritable bowel syndrome (IBS) is a functional gastrointestinal disorder (FGID), whose prevalence has widely increased in pediatric population during the past two decades. The exact pathophysiological mechanism underlying IBS is still uncertain, thus resulting in challenging diagnosis and management. Experts from 4 Italian Societies participated in a Delphi consensus, searching medical literature and voting process on 22 statements on both diagnosis and management of IBS in children. Recommendations and levels of evidence were evaluated according to the grading of recommendations, assessment, development, and evaluation (GRADE) criteria...
March 14, 2024: Italian Journal of Pediatrics
https://read.qxmd.com/read/38485558/enterocolitis-and-other-immunotherapy-and-targeted-therapy-related-gastrointestinal-manifestations-a-review-for-gastroenterologist
#24
REVIEW
O Gómez Escudero
New oncologic treatments, particularly immunotherapy (IT), have revolutionized the treatment of advanced-stage malignant tumors. Immune checkpoint inhibitors are the main form of IT and act by increasing T cell activity and the organism's immune response against neoplastic cells. Targeted therapy is another form of IT that acts by inhibiting oncogenes or inflammation signaling and tumor angiogenesis pathways. However, these mechanisms of tumor destruction can interfere with the host's immune self-tolerance or with the mechanisms of epithelial tissue repair and predispose to immune system-mediated adverse events that can affect multiple organs, including the digestive tract...
March 13, 2024: Revista de Gastroenterología de México
https://read.qxmd.com/read/38481933/gastric-sarcoidosis-diagnosed-with-endoscopic-ultrasound
#25
Husam El Sharu, Stephanie Ibarra, Ammad Chaudhary, Sinda Hidri, Zarak Khan, Danielle Hoo-Fatt
KEY CLINICAL MESSAGE: Endoscopic ultrasonography (EUS) is crucial in diagnosing gastrointestinal sarcoidosis, especially when patients exhibit refractory abdominal symptoms. Our case highlights the significance of considering sarcoidosis in such cases and emphasizes the utility of EUS for accurate diagnosis and guiding appropriate treatment. ABSTRACT: Gastrointestinal sarcoidosis is a rare and challenging manifestation of sarcoidosis that often presents with nonspecific abdominal symptoms, making diagnosis a complex process...
March 2024: Clinical Case Reports
https://read.qxmd.com/read/38481786/isolated-nonspecific-terminal-ileitis-prevalence-clinical-evolution-and-correlation-with-metachronous-diagnosis-of-crohn-s-disease-a-retrospective-study-and-review-of-the-literature
#26
JOURNAL ARTICLE
Evgenia Koureta, Pantelis Karatzas, Maria Tampaki, Theodoros Voulgaris, Efrosini Laoudi, Stratigoula Sakellariou, Ioanna Delladetsima, George Karamanolis, Jiannis Vlachogiannakos, George V Papatheodoridis
BACKGROUND: The existing literature does not provide adequate guidance on the diagnosis and management of patients with nonspecific terminal ileitis, while data regarding the percentage of patients who ultimately develop Crohn's disease (CD) are scarce. We evaluated the prevalence and natural course of nonspecific terminal ileitis in patients who underwent colonoscopy during a 11-year period. METHODS: All patients with endoscopic findings of terminal ileitis and nonspecific histological findings were included...
2024: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://read.qxmd.com/read/38479922/a-case-report-of-lactobacillus-bacteremia-in-a-patient-on-chronic-parenteral-nutrition
#27
JOURNAL ARTICLE
Hannah W Fiske, Breton Roussel, Marion Winkler, Benjamin Hall
BACKGROUND AND AIMS: Short bowel syndrome is a malabsorption disorder typically caused by the physical loss of a portion of the intestine, whereafter the body is unable to adequately absorb nutrients, fluids, and electrolytes. Many patients with short bowel syndrome are reliant on home parenteral nutrition through a tunneled or peripherally inserted central catheter to ensure sufficient hydration and nutrition. Central venous catheters are a nidus for bacteria, and patients are at risk for infections associated with high levels of morbidity and mortality...
April 2024: Clinical Nutrition ESPEN
https://read.qxmd.com/read/38476122/the-dosing-strategy-to-improve-adherence-to-roflumilast-in-treatment-for-chronic-obstructive-lung-disease-a-systemic-review-and-meta-analysis
#28
JOURNAL ARTICLE
Jonghoo Lee, Jae-Uk Song
BACKGROUND: The clinical efficacy of roflumilast, an oral phosphodiesterase-4 inhibitor, has been demonstrated in patients with severe chronic obstructive pulmonary disease (COPD). However, roflumilast has shown frequent adverse drug reactions (ADRs). This study was performed to investigate the dosing strategy that will improve adherence to roflumilast in COPD. METHODS: We conducted a systematic review and meta-analysis using PubMed, Embase, and Cochrane Central Register...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38468739/association-of-putative-virulence-genes-with-hep-2-cell-adherence-and-biofilm-production-in-enteroaggregative-e-coli-strains-isolated-from-acute-diarrheal-and-healthy-children-india
#29
JOURNAL ARTICLE
Vinay Modgil, Harpreet Kaur, Balvinder Mohan, Neelam Taneja
Enteroaggregative  Escherichia coli  (EAEC) is an emerging enteric pathogen that causes acute and chronic diarrhea in developed and industrialized countries in children. EAEC colonizes the human intestine and this ability to form colonies and biofilm is an important step in pathogenesis. Here, we investigated the relationship between known or putative 22 EAEC virulence genes and biofilm formation in isolates derived from acute diarrhea and healthy children and their aggregative adherence (AA) pattern with Hep-2 cell lines...
March 2024: Indian Journal of Microbiology
https://read.qxmd.com/read/38467503/effect-of-moxibustion-on-colonic-low-grade-inflammatory-response-in-rats-with-diarrhea-predominant-irritable-bowel-syndrome-based-on-mast-cell-degranulation
#30
JOURNAL ARTICLE
Ming Fang, Haoran Chu, Xiaoge Song, Jingru Ruan, Ling Zou, Kuiwu Li, Lumin Liao, Wenli Ma, Xiaoyu Han, Jingwei Zhu, Ziye Wang, Yucheng Fang
OBJECTIVES: To observe the effects of moxibustion on colonic mast cell degranulation and inflammatory factor expression in rats with diarrhea-predominant irritable bowel syndrome (IBS-D), and explore the potential mechanism of moxibustion in treating IBS-D. METHODS: Forty-five rat pups born from 5 healthy SPF-grade pregnant SD rats, with 8 rats were randomly selected as the normal group. The remaining 37 rats were intervened with maternal separation, acetic acid enema, and chronic restraint stress to establish the IBS-D model...
March 12, 2024: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://read.qxmd.com/read/38465131/tropical-sprue-a-rare-cause-of-malabsorption-syndrome
#31
Catarina Costa, Francisca Bartilotti Matos, Diogo Carvalho Sá, João Neves Maia
Chronic diarrhea is a common disorder in tropical regions, affecting residents, visitors, and even expatriates. It may stem from a myriad of infectious, inflammatory, and even malignant causes. In patients in whom no etiology has been found, tropical sprue (TS) is an important diagnosis to consider. We report the case of a 60-year-old man originally from Guatemala, presenting with chronic diarrhea and megaloblastic anemia due to severe vitamin B12 deficiency. Biopsies of the small bowel revealed partial villous atrophy and inflammatory infiltrate with the participation of eosinophils...
February 2024: Curēus
https://read.qxmd.com/read/38465053/an-atypical-case-of-yersinia-enterocolitica-infection-in-a-patient-suspected-with-ulcerative-colitis-flare-up
#32
Priyam Doshi, Ghomathy Sivaram, Corey Sievers
Ulcerative colitis (UC), one of the two major inflammatory bowel diseases (IBD), is a chronic immune-mediated inflammatory disorder with varying degrees of colonic mucosal involvement. Patients often present with inflammation limited to the rectum, also known as ulcerative proctitis, proximal colonic involvement, or pancolitis which affects the entire colon. Clinical manifestations of UC flare-ups include hematochezia, diarrhea, and abdominal pain. Yersinia enterocolitica , an acute cause of infectious diarrhea, is usually caused by the ingestion of food products contaminated with toxins and pathogens...
February 2024: Curēus
https://read.qxmd.com/read/38464922/assessment-of-the-triglyceride-glucose-index-in-adult-patients-with-chronic-diarrhea-and-constipation
#33
JOURNAL ARTICLE
Jing-Yi Zhu, Mu-Yun Liu, Chang Sun
BACKGROUND: Accumulating evidence suggests that the gut microbiome is involved in the pathogenesis of insulin resistance (IR). However, the link between two of the most prevalent bowel disorders, chronic diarrhea and constipation, and the triglyceride glucose (TyG) index, a marker of IR, has not yet been investigated. AIM: To investigate the potential association between TyG and the incidence of chronic diarrhea and constipation. METHODS: This cross-sectional study enrolled 2400 participants from the National Health and Nutrition Examination Survey database from 2009-2010...
February 26, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38459691/congenital-sucrase-isomaltase-deficiency-in-t%C3%A3-rkiye-a-single-center-experience
#34
JOURNAL ARTICLE
Doğan Barut, Ezgi Kıran Taşcı, Bora Kunay, Burcu Güven, Betül Aksoy, Yeliz Çağan Appak, Miray Karakoyun, Funda Çetin, Ayşe Selimoğlu, Huseyin Onay, Sema Aydoğdu
BACKGROUND: Congenital sucrase-isomaltase deficiency (CSID) is a rare inherited carbohydrate malabsorption disorder caused by sucrase-isomaltase ( SI ) gene variants. In CSID, an autosomal recessively inherited disease, symptoms can also be seen in individuals with heterozygous mutations. METHODS: The variant spectrum was evaluated retrospectively in individuals who presented with chronic diarrhea between 2014 and 2022 and had undergone genetic testing of the SI gene considering CSID due to diet-related complaints...
March 8, 2024: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/38459224/new-insights-into-the-clinical-and-molecular-spectrum-of-the-madd-related-neurodevelopmental-disorder
#35
JOURNAL ARTICLE
Ghada M H Abdel-Salam, Mohamed S Abdel-Hamid
Biallelic pathogenic variants in MADD lead to a very rare neurodevelopmental disorder which is phenotypically pleiotropic grossly ranging from severe neonatal hypotonia, failure to thrive, multiple organ dysfunction, and early lethality to a similar but milder phenotype with better survival. Here, we report 5 patients from 3 unrelated Egyptian families in whom 4 patients showed the severe end of the spectrum displaying neonatal respiratory distress, hypotonia and chronic diarrhea while one patient presented with the mild form displaying moderate intellectual disability and myopathy...
March 8, 2024: Journal of Human Genetics
https://read.qxmd.com/read/38455854/the-skin-as-a-window-to-the-gut-a-case-of-carcinoid-syndrome
#36
Catarina Alves Costa, Tânia Lopes, Ana Patrícia Rodrigues, Nuno Jorge Lamas, Célia Cruz
Neuroendocrine tumors (NETs) are a group of uncommon neoplasms derived from enterochromaffin or Kulchitsky cells (that secrete serotonin or other molecules into the bloodstream), which can manifest with symptoms of hormonal overproduction, namely carcinoid syndrome (CS). This can be the presenting feature in patients with advanced disease. We report the case of a 66-year-old woman presenting with chronic diarrhea, facial venous telangiectasia and elevated urinary 5-hydrocyindoleacetic acid levels. A 68-Ga DOTATOC PET/CT scan revealed an ileal mass and lesions consistent with liver, ovary and bone metastasis...
March 2024: Clinical Case Reports
https://read.qxmd.com/read/38453435/efficacy-tolerability-and-safety-of-the-oral-phosphate-binder-vs-505-ap301
#37
JOURNAL ARTICLE
Bing Zhuang, Liangying Gan, Bin Liu, Weijie Yuan, Ming Shi, Ai Peng, Lihua Wang, Xiaolan Chen, Tongqiang Liu, Shiying Zhang, Song Wang, Qing Gao, Baoxing Wang, Huixiao Zheng, Changhua Liu, Yuan Luo, Hong Ye, Hongli Lin, Yiwen Li, Qiang He, Feng Zheng, Ping Luo, Gang Long, Wei Lu, Kanghui Li, Junwei Yang, Yingxue Cathy Liu, Zhizheng Zhang, Xiaolin Li, Weifeng Zhang, Li Zuo
BACKGROUND: VS-505 (AP301), an acacia and ferric oxyhydroxide polymer, is a novel fiber-iron-based phosphate binder. This two-part phase 2 study evaluated the tolerability, safety, and efficacy of oral VS-505 administered three times daily with meals in treating hyperphosphatemia in chronic kidney disease (CKD) patients receiving maintenance hemodialysis (MHD). METHODS: In Part 1, patients received dose-escalated treatment with VS-505 2.25, 4.50, and 9.00 g/day for 2 weeks each, guided by serum phosphorus levels...
March 7, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38451674/evaluating-lactoferrin-and-calprotectin-as-markers-of-intestinal-inflammation-inchronic-pancreatitis
#38
JOURNAL ARTICLE
Claudia Teresa Carvente, Maria Lúcia Cardoso Gomes Ferraz, Carlos Fischer de Toledo
BACKGROUND: The treatment of chronic pancreatitis does not consistently solve intestinal abnormalities, and despite the implementation of various therapeutic measures, patients often continue to experience persistent diarrhea. Therefore, it is imperative to recognize that diarrhea may stem from factors beyond pancreatic insufficiency, and intestinal inflammation emerges as a potential contributing factor. OBJECTIVE: The aim of this study was to assess fecal lactoferrin and calprotectin levels as indicators of intestinal inflammation in patients with chronic pancreatitis experiencing persistent diarrhea...
2024: Arquivos de Gastroenterologia
https://read.qxmd.com/read/38451666/warning-to-delay-in-diagnosing-microscopic-colitis-in-older-adults-a-series-of-cases
#39
JOURNAL ARTICLE
Lorete Maria da Silva Kotze, Luiz Roberto Kotze, Raquel Canzi Almada de Souza, Paulo Gustavo Kotze, Renato Nisihara
BACKGROUND: Microscopic colitis (MC) is a chronic inflammatory bowel disease causing non-bloody diarrhea, and several cases are undiagnosed as a hidden cause of chronic diarrhea. OBJECTIVE: We aimed to report the symptoms, delay diagnosis and the treatment of MC in a case series. METHODS: All patients were treated at a Gastroenterology reference office from May 2022 to June 2023. Personal history including preexisting disorders, use of medications and smoking habits were collected...
2024: Arquivos de Gastroenterologia
https://read.qxmd.com/read/38450523/-gastrocolic-fistula-as-infrequent-cause-of-chronic-diarrhea-in-a-patient-with-percutaneous-radiological-gastrostomy
#40
JOURNAL ARTICLE
Carmen Gándara Gutiérrez, Carlos Alonso Felgueroso, Lucía Díaz Naya, Marta Diéguez Felechosa, Silvia González Martínez, Gala Gutiérrez Buey, Lucía Lázaro Martín, M ª Pilar Monge Rafael, Brenda Veiguela Blanco, Guillén Octavio Puente Barbé, María Pasarón Fernández, Laura Nozal García, Covadonga Suárez-Coalla Bango, Lucía Fernández Iglesias, María Riestra-Fernández
INTRODUCTION: gastrocolic fistula is an infrequent but severe complication of percutaneous gastrostomy. Clinical suspicion in the presence of chronic diarrhea of unknown etiology manifesting after percutaneous radiological gastrostomy (PRG) tube replacement is key to early detection and treatment. CASE REPORT: we report the case of a patient with PRG that began with chronic diarrhea after tube replacement and developed severe malnutrition. Initial treatment was not effective, studies were extended with the finding of this complication in a CT image...
February 27, 2024: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
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