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https://www.readbyqxmd.com/read/29663515/determining-optimal-therapy-of-dogs-with-chronic-enteropathy-by-measurement-of-serum-citrulline
#1
Magda Gerou-Ferriani, Rhiannon Allen, Peter-John M Noble, Alexander J German, Marco Caldin, Daniel J Batchelor
BACKGROUND: Serum concentration of citrulline is a useful biomarker in human intestinal disease and indicates globally reduced enterocyte mass and absorptive function in various disease states. OBJECTIVES: To determine whether serum citrulline concentration is a biomarker in chronic enteropathy (CE) in dogs, to provide useful information regarding optimal treatment or to predict outcome. ANIMALS: Seventy-four dogs with CE and 83 breed- and age-matched hospital controls with no clinical signs of intestinal disease...
April 16, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29651973/the-clinical-and-immunological-features-of-patients-with-primary-antibody-deficiencies
#2
Gholamreza Azizi, Yasser Bagheri, Marzieh Tavakol, Forough Askarimoghaddam, Kiyoomars Poorrostami, Hosein Rafiemanesh, Reza Yazdani, Fatemeh Kiaee, Sima Habibi, Kosar Abouhamzeh, Hamed Mohammadi, Mostafa Qorbani, Hassan Abolhassani, Asghar Aghamohammadi
BACKGROUND: Primary antibody deficiency (PAD) comprises a range of diseases from early to late terminal B cells defects and is associated with the various clinical complications. METHODS: A total of 461 patients (311 males and 150 females) with PADs enrolled in the retrospective cohort study and for all patients' demographic information, clinical records and laboratory data were collected to investigate clinical complications. RESULTS: The most prevalent first presentations of immunodeficiency were respiratory tract infections in 63...
April 12, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29622900/unsuspected-small-bowel-crohn-s-disease-in-elderly-patients-diagnosed-by-video-capsule-endoscopy
#3
Che-Yung Chao, Carl Frederic Duchatellier, Ernest G Seidman
Background: Video capsule endoscopy (VCE) is increasingly performed among the elderly for obscure bleeding. Our aim was to report on the utility of VCE to uncover unsuspected Crohn's disease (CD) in elderly patients. Methods: Retrospective review of VCE performed in elderly patients (≥70 y) at a tertiary hospital (2010-2015). All underwent prior negative bidirectional endoscopies. CD diagnosis was based on consistent endoscopic findings, exclusion of other causes, and a Lewis endoscopic score (LS) > 790 (moderate-to-severe inflammation)...
2018: Diagnostic and Therapeutic Endoscopy
https://www.readbyqxmd.com/read/29621604/clostridioides-difficile-infection-in-dogs-with-chronic-recurring-diarrhea-responsive-to-dietary-changes
#4
Rodrigo Otávio Silveira Silva, Carlos Augusto de Oliveira Júnior, Dominique S Blanc, Silvia Trindade Pereira, Mário Cesar Rennó, Artur Vasconcelos, Francisco Carlos Faria Lobato
Five dogs with chronic-recurring diarrhea were positive for Clostridioides difficile infection (CDI), but were unresponsive to treatment with metronidazole. One of these animals was subjected to a colonoscopy, which revealed eosinophilic infiltration of the colon. All five animals completely recovered after dietary changes. The present work suggests that CDI might occur in dogs with other intestinal alterations. In addition, this report suggests that dysbiosis should be considered in animals that have chronic-recurring diarrhea and test positive for C...
April 2, 2018: Anaerobe
https://www.readbyqxmd.com/read/29619399/celiac-disease-and-secondary-amyloidosis-a-possible-causal-association
#5
Ankit Chhoda, Deepanshu Jain, Mradul Kumar Daga, Vineeta Batra
We report a rare case of secondary renal amyloidosis in a patient with probable celiac disease presenting as nephrotic syndrome. A 30-year-old man with chronic diarrhea presented with progressive anasarca for 2 years. On further evaluation, he had hypoalbuminemia, significant nephrotic-range proteinuria, and elevated levels of anti-tissue transglutaminase. Renal biopsy suggested deposition of amorphous Congo red-positive material in the glomerular mesangium, positive for amyloid A amyloidosis. Endoscopic duodenal biopsy suggested blunting of the villous architecture and chronic inflammation of the lamina propria...
2018: ACG Case Reports Journal
https://www.readbyqxmd.com/read/29617871/clinical-and-laboratory-predictors-of-shiga-toxin-producing-escherichia-coli-infection-in-children-with-bloody-diarrhea
#6
Ryan S McKee, Phillip I Tarr, Dennis J Dietzen, Rachit Chawla, David Schnadower
Objectives: Children with acute bloody diarrhea are at risk of being infected with Shiga toxin-producing Escherichia coli (STEC) and of progression to hemolytic uremic syndrome. Our objective was to identify clinical and laboratory factors associated with STEC infection in children who present with acute bloody diarrhea. Methods: We performed a prospective cohort study of consecutive children younger than 18 years who presented with acute (<2-week duration) bloody diarrhea between August 1, 2013, and August 1, 2014...
April 2, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29615382/severe-heinz-body-anemia-and-methemoglobinemia-in-a-kitten-with-chronic-diarrhea
#7
P Cavana, E Irato, B Miniscalco, P Gianella
A 2-month-old kitten was referred for depression and partial anorexia since 3 days and chronic diarrhea lasting for over 3 weeks. General physical examination showed pale and cyanotic mucous membranes. Blood sample was of brownish appearance. Venous blood gas analysis and complete blood count showed 16% methemoglobin level and severe regenerative anemia with Heinz bodies in about 40% of the erythrocytes, respectively. The kitten was transfused with fresh whole blood and treated with supportive care, antimicrobial and antioxidant agents...
April 2018: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/29615046/phytochemical-composition-antilipidemic-and-antihypercholestrolemic-perspectives-of-bael-leaf-extracts
#8
Nosheen Asghar, Zarina Mushtaq, Muhammad Umair Arshad, Muhammad Imran, Rabia Shabir Ahmad, Syed Makhdoom Hussain
BACKGROUND: In recent times, focus on plant research has improved all over the world and essential parts of plants provide bioactive compounds in human diet. The bael (Aegle marmelos) has enormous traditional uses in the treatment of chronic diarrhea, dysentery, peptic ulcers and as a laxative. The main focus of this study was characterization of bael leaf extract for its bioactive constituents, antihypercholestrolemic and antilipidemic perspectives. METHODS: After proximate composition of bael powder, the aqueous extract of bael leaf was used for phytochemical profiling (alkaloids, total phenolic content and total flavonoid content)...
April 3, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29614595/-the-462nd-case-chronic-watery-diarrhea-and-acute-kidney-injury
#9
Y H Ni, J Li, W X Zhou, Y P Luo, Q W Jiang, Y Liu, C Yue, G Sun, J M Qian
A 60-year-old man presented with severe watery diarrhea for 2 months complicated with weight loss and acute kidney injury. He did not respond well to antidiarrheal medicines, empirical antibiotics and dietary exclusion of gluten or even complete bowel rest. The final diagnosis of autoimmune enteropathy (AIE) was made based on histopathologic findings of endoscopic biopsy from duodenal mucosa after excluding neoplastic disease, inflammatory bowel disease, and infectious diarrhea, etc. Chronic diarrhea and oliguria alleviated after the administration of corticosteroids...
April 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29610757/the-subtypes-of-microscopic-colitis-from-a-pathologist-s-perspective-past-present-and-future
#10
Peter Johan Heiberg Engel, Anne-Marie Kanstrup Fiehn, Lars Kristian Munck, Martin Kristensson
Microscopic colitis (MC) is a chronic inflammatory bowel disease, encompassing a triad of chronic diarrhea, normal endoscopy and characteristic histological findings. MC embraces two histological subtypes described as lymphocytic colitis (LC) and collagenous colitis (CC). The diagnostic criteria of MC were established several years ago and the histological description of LC and CC was based almost exclusively on heamatoxylin-eosin (HE) stained sections. Since the establishment of the diagnostic criteria, important changes have occurred in the concept and diagnostic methods of MC: the emergence of the entity "microscopic colitis incomplete" (MCi), comprising collagenous colitis incomplete (CCi) and lymphocytic colitis incomplete (LCi) and pathologists' increasing use of special stains in everyday diagnostics...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29610515/demographic-and-dietary-associations-of-chronic-diarrhea-in-a-representative-sample-of-adults-in-the-united-states
#11
Prashant Singh, Shuji Mitsuhashi, Sarah Ballou, Vikram Rangan, Thomas Sommers, Vivian Cheng, Johanna Iturrino-Moreda, Daniel Friedlander, Judy Nee, Anthony Lembo
OBJECTIVES: No studies to date estimate the prevalence of chronic diarrhea in the United States using the Bristol stool form scale (BSFS). This study aims to report the prevalence and associated factors of chronic diarrhea using BSFS scores in a nationally representative sample of US adults. METHODS: We identified 5,246 adult participants (age ≥20 years) who completed the bowel health questionnaire in the National Health and Nutrition Examination Survey 2009-2010 data set...
April 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29610171/autoimmune-pancreatitis-and-ulcerative-rectocolitis-in-an-adolescent
#12
Elie Cousin, Ianis Cousin, Karim Aziz, Pascal Chailloux, Estelle Breton
Autoimmune pancreatitis (AIP) is rare in teenagers and difficult to diagnose. There are no clear and established diagnostic criteria in the pediatric population to distinguish subtype 1 and subtype 2. Here, we report the case of a 16-year-old white French teenager admitted to the pediatric emergency service with more than 1 year's history of pain originating from the epigastric and the right hypochondriac regions, with bloody diarrhea. After exclusion of pancreatic cancer and other common causes of acute pancreatitis, the diagnosis of AIP was suspected...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29601564/-nintedanib-in-the-treatment-of-fibrosing-interstital-lung-diseases
#13
REVIEW
Katarzyna Lewandowska
Nintedanib is an intracellular tyrosine kinase inhibitor approved in a treatment of idiopathic pulmonary fibrosis. It reduces the annual rate of forced vital capacity decline by approximately 50%, that results in slowing of disease progression. The drug also reduces the incidence of acute exacerbations of idiopathic pulmonary fibrosis. The efficacy of nintedanib was the same in different groups of patients, irrespectively to disease status, age, gender and race. The most frequent side effects were gastrointestinal, i...
March 27, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29582964/-the-nephrology-outpatient-triage-an-organizational-model-for-the-ambulatory-care-of-patients-with-advanced-renal-disease
#14
Giorgio Soragna, Francesca Bermond, Laura Fabbrini, Amelia Rodofili, Aldo Soragna, Maggiorina Bauducco, Aspasia Panunzi, Ada Ramondetti, Cristiana Cerri, Corrado Vitale
The clinical course of outpatients with advanced chronic kidney disease requires a close monitoring by the nephrology team, in order to identify emerging clinical problems promptly and prevent subsequent complications. With the aim of improving the outpatient management in our clinic dedicated to advanced renal failure, we implemented the "Nephrology Clinic Triage" (NCT). This organizational model is coordinated by the nephrologist and supported by nurses. In case the outpatients, or their caregivers, have clinical problems or need advice, they can easily get in touch with a nephrology nurse by a dedicated telephone line...
March 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29582628/self-confidence-and-quality-of-life-in-women-undergoing-treatment-for-breast-cancer
#15
Fahimeh Sehati Shafaee, Mojgan Mirghafourvand, Sepideh Harischi, Ali Esfahani, Jalileh Amirzehni
Introduction: Quality of life is an important topic in the study of chronic diseases, especially cancer which can have a major effect on patient self-confidence. This study was conducted to determine quality of life and its relationship with self-confidence in women undergoing treatment for breast cancer. Methods: This cross-sectional, descriptive, analytical study was conducted in 2016 on 166 women with breast cancer undergoing treatment at Ghazi, Al-Zahra, International and/or Shams hospitals in Tabriz. The subjects were selected through convenience sampling...
March 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29582273/-chronic-diarrhea-rational-diagnostic-and-therapy
#16
Ahmed Madisch
No abstract text is available yet for this article.
March 2018: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/29571021/linalyl-acetate-prevents-olmesartan-induced-intestinal-hypermotility-mediated-by-interference-of-the-sympathetic-inhibitory-pathway-in-hypertensive-rat
#17
Soonho Kwon, Yu Shan Hsieh, You Kyoung Shin, Purum Kang, Geun Hee Seol
Olmesartan-associated enteropathy (OAE) is a life-threatening pathological condition, but its underlying mechanisms have not been elucidated. Although intestinal hypermotility is frequently accompanied by chronic diarrhea, there have been no studies of olmesartan-induced hypermotility. Intestinal motility should be well regulated by the enteric nervous system, but degeneration of enteric neurons has been reported in patients with chronic diarrheal diseases, such as irritable bowel syndrome, suggesting a connection between OAE and intestinal hypermotility...
March 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29570102/evidence-for-somatic-hypersensitivity-in-veterans-with-gulf-war-illness-and-gastrointestinal-symptoms
#18
QiQi Zhou, Meghan L Verne, Buyi Zhang, G Nicholas Verne
INTRODUCTION: Over 25% of Persian Gulf War (PGW) veterans with Gulf War Illness (GWI) (chronic health complaints of undetermined etiology) developed GI symptoms (diarrhea and abdominal pain) and somatic complaints. OBJECTIVES: Our study objective was to determine if veterans with GWI and GI symptoms exhibit heightened patterns of somatic pain perception (hypersensitivity) across nociceptive stimuli modalities. METHODS: Subjects were previously deployed GW Veterans with GWI and GI symptoms (n=53); veterans with GWI without GI symptom (n=47); and veteran controls (n=38)...
March 21, 2018: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29567897/-strongyloides-stercoralis-hyperinfection-in-an-unconscious-diabetic-patient-with-dermatomyositis
#19
Meysam Sharifdini, Aniseh Hesari, Seif Ali Mahdavi, Akram Alipour, Eshrat Beigom Kia
A case of Strongyloides stercoralis hyperinfection in a patient with dermatomyositis and diabetes mellitus is herein reported. The case was a 60-year-old female admitted due to watery diarrhea and unconsciousness. She had a 10-year history of chronic immunosuppressive therapy including methotrexate and prednisolone for dermatomyositis. Stool parasitological examination revealed numerous rhabditiform larvae of threadworm "S. stercoralis." Larva in stool sample was characterized by sequencing of mitochondrial DNA...
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29562382/hepatic-schistosomiasis-with-massive-splenomegaly-a-case-report-and-literature-review
#20
L Thijs, P Messiaen, J van der Hilst, V Madoe, C Melis, P Van Eyken, I Vanmoerkerke, F Janssens
Schistosomiasis is a parasitic disease caused by Schistosoma species. Intestinal and hepatic schistosomiases are the most common forms of chronic disease. We describe a case of a 26-year old patient from Eritrea who was referred to our hospital with abdominal pain and diarrhea. The diagnosis of hepatosplenic schistosomiasis was made by liver biopsy and the patient was treated with praziquantel. Hepatic schistosomiasis is characterised by deposition of schistosomal eggs in the liver which results in a host cell immune response and leads to granuloma formation and neoangiogenesis...
January 2018: Acta Gastro-enterologica Belgica
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