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Juan Idiaquez, Juan Francisco Idiaquez, Rodrigo Iturriaga
OBJECTIVE: Arterial blood pressure (BP) increased in healthy humans in response to isometric handgrip (IHG), but the pattern of the relative contribution of cardiac output (CO) and total peripheral resistance (TPR) changes to the pressor response is different among individuals. We investigated weather patients with recurrent vasovagal syncope (VVS) have a similar pattern of individual CO, TPR and pressor responses to IHG, as healthy subjects. METHODS: 32 patients (27...
July 2018: Autonomic Neuroscience: Basic & Clinical
Jingyuan Song, Hongxia Li, Yuli Wang, Ping Liu, Xueying Li, Chaoshu Tang, Hongfang Jin, Junbao Du
The objective of this manuscript was to explore if left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) could predict the efficacy of metoprolol therapy on vasovagal syncope (VVS) in children. Forty-nine children, including 30 with VVS and 19 gender- and age-matched healthy controls, were included in the study. Metoprolol was prescribed to the VVS subjects. The clinical data were obtained during follow-up at 2 and 6 months. The results showed that LVEF and LVFS of responders were significantly higher than those of non-responders both at the 2-month follow-up (LVEF: 72...
May 16, 2018: Pediatric Cardiology
Dirk P Saal, Roland D Thijs, Erik W van Zwet, Marianne Bootsma, Michele Brignole, David G Benditt, J Gert van Dijk
OBJECTIVES: The purpose of this study was to investigate the relationship between the onset of asystole and transient loss of consciousness (TLOC) in tilt-induced reflex syncope and estimate how often asystole was the principal cause of TLOC. BACKGROUND: The presence of asystole in vasovagal syncope (VVS) may prompt physicians to consider pacemaker therapy for syncope prevention, but the benefit of pacing is limited in VVS. METHODS: We evaluated electrocardiography, electroencephalography, blood pressure, and clinical findings during tilt-table tests...
December 26, 2017: JACC. Clinical Electrophysiology
J Gert van Dijk, Roland D Thijs
No abstract text is available yet for this article.
September 2017: JACC. Clinical Electrophysiology
Inderjeet S Sahota, Connor Maxey, Payam Pournazari, Robert S Sheldon
OBJECTIVES: This study elucidated the temporal recurrence patterns of syncope in patients with frequent vasovagal syncope (VVS). BACKGROUND: Understanding the temporal distribution of fainting spells in syncope patients may illuminate biological processes and inform decision making. METHODS: Patients from the POST 2 (Prevention of Syncope Trial 2) were included; all had VVS and fainted ≥4 times in the study year, providing ≥3 interevent intervals (IEIs)...
September 2017: JACC. Clinical Electrophysiology
Cristina E Firanescu, Jolanda de Vries, Paul Lodder, Alexander Venmans, Marinus C Schoemaker, Albert J Smeet, Esther Donga, Job R Juttmann, Caroline A H Klazen, Otto E H Elgersma, Frits H Jansen, Alexander V Tielbeek, Issam Boukrab, Karen Schonenberg, Willem Jan J van Rooij, Joshua A Hirsch, Paul N M Lohle
OBJECTIVE: To assess whether percutaneous vertebroplasty results in more pain relief than a sham procedure in patients with acute osteoporotic compression fractures of the vertebral body. DESIGN: Randomised, double blind, sham controlled clinical trial. SETTING: Four community hospitals in the Netherlands, 2011-15. PARTICIPANTS: 180 participants requiring treatment for acute osteoporotic vertebral compression fractures were randomised to either vertebroplasty (n=91) or a sham procedure (n=89)...
May 9, 2018: BMJ: British Medical Journal
Kai O Hensel, Markus Roskopf, Francisca Abellan Schneyder, Andreas Heusch
BACKGROUND: Data on left ventricular (LV) function in patients with neurocardiogenic syncope (NS) is conflicting in adults and lacking in children. The aim of this study was to analyze LV myocardial performance in children with NS at rest and during head-up tilt-table (HUTT) testing. METHODS: This is the first study to combine HUTT and speckle-tracking echocardiography (STE) in children with NS. 43 consecutive normotensive pediatric patients with NS (mean age 13...
May 8, 2018: BMC Cardiovascular Disorders
Jennifer Anderson, Yael Bensoussan, Richard Townsley, Erika Kell
Objective To review complications of in-office endoscopic laryngeal laser procedures after implementation of standardized safety protocol. Methods A retrospective review was conducted of the first 2 years of in-office laser procedures at St Michaels Hospital after the introduction of a standardized safety protocol. The protocol included patient screening, procedure checklist with standardized reporting of processes, medications, and complications. Primary outcomes measured were complication rates of in-office laryngeal laser procedures...
May 1, 2018: Otolaryngology—Head and Neck Surgery
Nathalie Virag, Mark Erickson, Patricia Taraborrelli, Rolf Vetter, Phang Boon Lim, Richard Sutton
BACKGROUND: We developed a vasovagal syncope (VVS) prediction algorithm for use during head-up tilt with simultaneous analysis of heart rate (HR) and systolic blood pressure (SBP). We previously tested this algorithm retrospectively in 1155 subjects, showing sensitivity 95%, specificity 93% and median prediction time of 59s. OBJECTIVE: This study was prospective, single center, on 140 subjects to evaluate this VVS prediction algorithm and assess if retrospective results were reproduced and clinically relevant...
April 28, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Goun Jeong, Son Moon Shin, Nam Su Kim, Young Min Ahn
Purpose: This study aimed to investigate the clinical and socioenvironmental characteristics of sudden cardiorespiratory arrest after venipuncture in children. Methods: We conducted a retrospective email-based survey of all members of the Korean Pediatric Society. The questionnaire included items on patient demographics, socioenvironmental circumstances of the venipuncture, type of cardiorespiratory arrest, symptoms and signs, treatment, prognosis, and presumed cause of the arrest...
April 2018: Korean Journal of Pediatrics
Victor E Staartjes, Shiva A Schillevoort, Patricia G Blum, J Peter van Tintelen, Wouter E Kok, Marc L Schröder
OBJECTIVE: Intraoperative cardiac arrest (CA) is usually attributable to pre-existing disease, or to intraoperative complications. In rare cases, intraoperative stress can demask certain genetic diseases, such as Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT). It is essential that neurosurgeons are aware of the etiologies, risk factors, and initial management of CA during surgery in the prone position. METHODS: We present a case of CA directly after spinal fusion for lumbar spondylolisthesis, and review the literature on cardiac arrests during spinal neurosurgery in the prone position...
April 26, 2018: World Neurosurgery
Tuoyu Gan, Lijia Wu, Runmei Zou, Ping Lin, Fang Li, Hong Yang, Ping Liu, Xiaohui Gong, Cheng Wang
To explore the relationship between unexplained palpitation in children and head-up tilt test (HUTT).
 Methods: A total of 142 children with the main symptom of unexplained palpitation were admitted to the Specialist Out-Patient Clinic of Children's Cardiovascular Disease from Sept. 2008 to Feb. 2017 in the Second Xiangya Hospital, Central South University. Among them, 63 cases were male, 79 cases were female, with the mean age of (10.12±2.88) years old. The detailed history, physical examinations, conventional 12 electrocardiogram, chest X-ray, echocardiography, myocardial enzymes and thyroid function were all examined...
March 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Ritsuko Kohno, Wayne O Adkisson, David G Benditt
Head-up tilt (HUT) has long been used to examine heart rate and blood pressure adaptation to changes in position. During such studies, incidental observations noted that some test subjects experienced total or near-total transient loss of consciousness and that, in some cases, hypotension was associated with unexpected marked bradycardia compatible with a vasovagal syncope (VVS) reaction. The first report of HUT as a clinical tool to confirm a diagnosis of suspected VVS was published in 1966, and led to the concept of using HUT as a diagnostic tool for VVS...
April 25, 2018: Herzschrittmachertherapie & Elektrophysiologie
Bruna C Brüler, Thayane C Vieira, Marcela Wolf, Stephany B Lucina, Fabiano Montiani-Ferreira, Marlos G Sousa
Congestive heart failure (CHF) is characterized by reduced heart rate variability. Although various methods to achieve parasympathetic withdrawal and sympathetic activation have been documented, stimulation of the vagal nerve (that is, vagal maneuvers) has not often been used to assess the autonomic impairment associated with disease progression in veterinary species. In this study, we investigated cardiac autonomic control in a naturally occurring canine model of mitral insufficiency by means of individual responses to oculocardiac reflex...
April 2, 2018: Comparative Medicine
Yoichi Naito, Hideaki Takahashi, Kohei Shitara, Wataru Okamoto, Hideaki Bando, Takeshi Kuwata, Yasutoshi Kuboki, Shingo Matsumoto, Izumi Miki, Takeharu Yamanaka, Atsushi Watanabe, Motohiro Kojima
Background: To confirm the feasibility and explore the clinical applicability of amplicon sequencing by next generation sequencing (NGS) of biopsy samples from patients with advanced solid tumors, we conducted a prospective study. Methods: Patients with unresectable, advanced, or recurrent solid tumors were included. Key eligibility criteria were as follows: 20 years or older, any planned systemic therapy, adequate lesion for biopsy, and written informed consent...
April 12, 2018: Japanese Journal of Clinical Oncology
Manlio F Márquez, Ricardo Allende, Ricardo Márquez-Velasco, Antonio G Hermosillo
No abstract text is available yet for this article.
May 2018: Heart: Official Journal of the British Cardiac Society
Xichun Yu, Hongliang Li, Taylor A Murphy, Zachary Nuss, Jonathan Liles, Campbell Liles, Christopher E Aston, Satish R Raj, Artur Fedorowski, David C Kem
BACKGROUND: Both the adrenergic and renin-angiotensin systems contribute to orthostatic circulatory homeostasis, which is impaired in postural orthostatic tachycardia syndrome (POTS). Activating autoantibodies to the α1-adrenergic and β1/2-adrenergic receptors have previously been found in sera from patients with POTS. We hypothesized that patients with POTS might also harbor activating autoantibodies to the angiotensin II type 1 receptor (AT1R) independently of antiadrenergic autoimmunity...
April 4, 2018: Journal of the American Heart Association
Robert A Larson, Mark W Chapleau
No abstract text is available yet for this article.
April 3, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
Daljit Kaur, Manoj Kandwal
Plateletpheresis procedures are considered safe for donors and very few adverse events are reported. Donor related adverse events include hypo-calcemia due to citrate toxicity, vasovagal reactions, transient post-procedural decline in hemoglobin, hematocrit and platelet count. Kit related adverse events include damage of the kit or rarely mechanical damage of the red cells during procedure. This damage can lead to failure of the rinse-back of the red cells to the donors causing higher red cell loss in such donors...
March 26, 2018: Transfusion and Apheresis Science
Hongxia Li, Ying Liao, Zhenhui Han, Yuli Wang, Ping Liu, Chunyu Zhang, Chaoshu Tang, Junbao Du, Hongfang Jin
AIM: This study examined the total peripheral vascular resistance (TPVR) and cardiac output changes due to the head-up tilt test (HUTT) in children with vasovagal syncope (VVS). METHODS: From December 2013 to January 2016, we recruited 77 children diagnosed with VVS group at Peking University First Hospital, China, and 28 children without VVS provided the control group. Heart rate, blood pressure, TPVR, cardiac output and baroreflex sensitivity were monitored during the HUTT...
March 30, 2018: Acta Paediatrica
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