Jian Zheng, Wai-Lan Wu, Yinping Liu, Zheng Xiang, Ming Liu, Kwok-Hung Chan, Siu-Ying Lau, Kwok-Tai Lam, Kelvin Kai-Wang To, Jasper Fuk-Woo Chan, Lanjuan Li, Honglin Chen, Yu-Lung Lau, Kwok-Yung Yuen, Wenwei Tu
A novel avian influenza virus H7N9 infection occurred among human populations since 2013. Although the lack of sustained human-to-human transmission limited the epidemics caused by H7N9, the late presentation of most patients and the emergence of neuraminidase-resistant strains made the development of novel antiviral strategy against H7N9 in urgent demands. In this study, we evaluated the potential of pamidronate, a pharmacological phosphoantigen that can specifically boost human Vδ2-T-cell, on treating H7N9 virus-infected humanized mice...
2015: PloS One