Martina Borcinova, Robin Bartolini, Lily Koumbas Foley, Vojtech Novak, Pavla Taborska, Dmitry Stakheev, Michal Rataj, Daniel Smrz, Martina Fialova, Jaromir Hacek, Martin Komarc, Stepan Vesely, Marek Babjuk, Ilja Striz, Jirina Bartunkova, Tomas Buchler, Zuzana Ozaniak Strizova
Renal cell carcinoma (RCC) is a common malignancy frequently diagnosed at the metastatic stage. We performed a comprehensive analysis of the tumor immune microenvironment (TIME) in RCC patients, including the peritumoral tissue microenvironment, to characterize the phenotypic patterns and functional characteristics of infiltrating immune cells. T cells from various compartments (peripheral blood, tumor, peritumoral area, and adjacent healthy renal tissue) were assessed using flow cytometry and Luminex analyses, both before and after T cell-specific stimulation, to evaluate activation status and migratory potential...
February 3, 2024: Translational Oncology