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https://www.readbyqxmd.com/read/28724282/survival-nomograms-after-curative-neoadjuvant-chemotherapy-and-radical-surgery-for-stage-ib2-iiib-cervical-cancer
#1
Claudia Marchetti, Francesca De Felice, Anna Di Pinto, Alessia Romito, Angela Musella, Innocenza Palaia, Marco Monti, Vincenzo Tombolin, Ludovico Muzii, PierLuigi Benedetti Panici
Purpose: To develop nomograms for predicting the probability of overall survival (OS) and progression-free survival (PFS) in locally advanced cervical cancer treated with neoadjuvant chemotherapy and radical surgery . Materials and Methods: Nomograms to predict the 5-year OS rates and the 2-year PFS rates were constructed. Calibration plots were constructed, and concordance indices were calculated. Evaluated variables were body mass index, age, tumor size, tumor histology, grading, lymphovascular space invasion, positive parametria and positive lymph-nodes...
July 19, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28724262/phytohormones-and-induction-of-plant-stress-tolerance-and-defense-genes-by-seed-and-foliar-inoculation-with-azospirillum-brasilense-cells-and-metabolites-promote-maize-growth
#2
Josiane Fukami, Francisco Javier Ollero, Manuel Megías, Mariangela Hungria
Azospirillum spp. are plant-growth-promoting bacteria used worldwide as inoculants for a variety of crops. Among the beneficial mechanisms associated with Azospirillum inoculation, emphasis has been given to the biological nitrogen fixation process and to the synthesis of phytohormones. In Brazil, the application of inoculants containing A. brasilense strains Ab-V5 and Ab-V6 to cereals is exponentially growing and in this study we investigated the effects of maize inoculation with these two strains applied on seeds or by leaf spray at the V2...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28724259/herbal-pre-conditioning-induces-proliferation-and-delays-senescence-in-wharton-s-jelly-mesenchymal-stem-cells
#3
Avinash Sanap, Bhawna Chandravanshi, Tejas Shah, Girish Tillu, Anand Dhanushkodi, Ramesh Bhonde, Kalpana Joshi
BACKGROUND: Mesenchymal Stem Cells (MSCs) are multipotent stem cells which are being explored for various clinical applications. Isolation and in-vitro expansion of MSCs remain important in achieving desired cell number for the therapy. However, in-vitro proliferation of MSCs is often associated with senescence and early onset of apoptosis which limits its therapeutic ability and long term clinical use. Tinospora cordifolia and Withania somnifera are used widely in Ayurveda: the traditional Indian system of medicine and are reported to have rejuvenating and anti-aging potential...
July 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28724256/first-study-to-explore-the-feasibility-of-applying-microbial-fuel-cells-into-constructed-wetlands-for-cod-monitoring
#4
Lei Xu, Yaqian Zhao, Chuang Fan, Zhiren Fan, Fangchao Zhao
Chemical oxygen demand (COD) is one of the major targets to remove in constructed wetlands (CWs) system. Traditional method for COD measurement is a complex, time-consuming and highly toxic reagents participated procedure. In this study, microbial fuel cell (MFC) was successfully integrated into CW for indicating COD concentration. Results showed that there are two linear correlations between bioelectrical signals (output voltage from MFC) and COD concentration (acetate), which are COD from 0 to 500mg/L (101...
July 1, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28724249/occurrence-and-source-apportionment-of-atmospheric-halogenated-flame-retardants-in-lhasa-city-in-the-tibetan-plateau-china
#5
Wan-Li Ma, Wen-Long Li, Zi-Feng Zhang, Li-Yan Liu, Wei-Wei Song, Chun-Yan Huo, Yi-Xing Yuan, Yi-Fan Li
Active air samples were collected in Lhasa, one of the highest cities in the world (3650m above sea level) located in the Tibetan Plateau, and were analyzed for 38 halogenated flame retardants (HFRs), including polybrominated diphenyl ethers (PBDEs), non-PBDE brominated flame retardants (NBFRs) and dechlorane plus (DPs). The median concentrations of PBDEs, NBFRs and DPs were 40, 23 and 0.21pg/m(3), respectively. Correlation analysis indicated the common source and/or similar environmental behavior for several HFRs...
July 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724244/evaluating-mercury-concentrations-and-body-condition-in-american-alligators-alligator-mississippiensis-at-merritt-island-national-wildlife-refuge-minwr-florida
#6
Frances M Nilsen, Jonathan E Dorsey, Russell H Lowers, Louis J Guillette, Stephen E Long, John A Bowden, Tracey B Schock
Concentrations of mercury (Hg) are not well studied in free-ranging wildlife. Atmospheric deposition patterns of Hg have been studied in detail and have been modeled for both global and specific locations and often correlate to environmental impact. However, monitoring the impact of Hg deposition in wildlife is complicated due to local environmental conditions that can affect the transformation of atmospheric Hg to the biologically available forms (e.g., rainfall, humidity, pH, the ability of the environment to methylate Hg), as well as affect the accessibility to organisms for sampling...
July 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724227/carbon-and-nitrogen-allocation-strategy-in-posidonia-oceanica-is-altered-by-seawater-acidification
#7
Andrea Scartazza, Stefano Moscatello, Olga Gavrichkova, Maria Cristina Buia, Marco Lauteri, Alberto Battistelli, Maurizio Lorenti, Samantha Laird Garrard, Carlo Calfapietra, Enrico Brugnoli
Rising atmospheric CO2 causes ocean acidification that represents one of the major ecological threats for marine biota. We tested the hypothesis that long-term exposure to increased CO2 level and acidification in a natural CO2 vent system alters carbon (C) and nitrogen (N) metabolism in Posidonia oceanica L. (Delile), affecting its resilience, or capability to restore the physiological homeostasis, and the nutritional quality of organic matter available for grazers. Seawater acidification decreased the C to N ratio in P...
July 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724223/chromium-vi-adsorption-from-wastewater-using-porous-magnetite-nanoparticles-prepared-from-titanium-residue-by-a-novel-solid-phase-reduction-method
#8
Genkuan Ren, Xinlong Wang, Penghui Huang, Benhe Zhong, Zhiye Zhang, Lin Yang, Xiushan Yang
Porous magnetite nanoparticles were successfully synthesized by reduction of titanium residue with pyrite under nitrogen protection, and characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy, vibrating sample magnetometer, X-ray photoelectron spectroscope, zeta potential and Brunauer-Emmett-Teller method. The XRD analysis confirmed the formation of porous magnetite nanoparticles with single spinel structure. The SEM image demonstrated that porous magnetite nanoparticles displayed spherical shape with the average diameter of ~51nm...
July 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724221/impact-of-the-nsaid-diclofenac-on-survival-development-behaviour-and-health-of-embryonic-and-juvenile-stages-of-brown-trout-salmo-trutta-f-fario
#9
Simon Schwarz, Hannah Schmieg, Marco Scheurer, Heinz-R Köhler, Rita Triebskorn
The NSAID diclofenac is controversially discussed with respect to its environmental relevance. Since further information is need to assess whether diclofenac should be included as substance of priority in the EU water framework directive, we investigated the impact of this analgesic on the embryonic development of brown trout (Salmo trutta f. fario) from fertilized egg until the end of sac-fry stage and studied effects in juvenile fish six months post hatch. Embryos were exposed to five test concentrations (0...
July 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724216/the-extract-from-punica-granatum-pomegranate-peel-induces-apoptosis-and-impairs-metastasis-in-prostate-cancer-cells
#10
Yuanle Deng, Yali Li, Fangfang Yang, Anqi Zeng, Shuping Yang, Yi Luo, Yiwen Zhang, Yongmei Xie, Tinghong Ye, Yong Xia, Wenya Yin
Prostate cancer is a big threat to male for its poor prognosis and high mortality rate. Natural compounds are important resources of many anticancer drugs. Pomegranate is a kind of antioxidant-rich fruit and its peel and seed has potential anticancer activities. In this study, we aimed to investigate the effects of pomegranate peel extract (PoPx) on the apoptosis and metastasis of prostate cancer cells and the related mechanism. We found that PoPx showed growth inhibition on prostate cancer cells. Nuclei morphological and flow cytometer (FCM) analysis indicated that PoPx could induce prostate cancer apoptosis...
July 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28724214/potential-protective-effects-of-alpha-pinene-against-cytotoxicity-caused-by-aspirin-in-the-iec-6-cells
#11
Hafsia Bouzenna, Najla Hfaiedh, Marie-Agnès Giroux-Metges, Abdelfattah Elfeki, Hélène Talarmin
Alpha-pinene is a key compound of the essential oils extracted from many species of coniferous trees. It is known for its biological activities. The aim of the present study was to determine the preventive effect of alpha-pinene on aspirin-induced toxicity in vitro, using IEC-6 cells, and to investigate its antioxidant activities. The antioxidant activities were determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP). The cytotoxicity and oxidative stress were detected by cell viability, antioxidant enzyme activity, malondialdehyde (MDA) and GSH production, and the activation of MAPK pathways...
July 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28724213/characterization-of-serum-estradiol-level-and-tissue-estrogen-receptor-immunostaining-with-clinical-response-and-reproductive-factor-changes-in-chinese-female-patients-with-esophageal-squamous-cell-carcinoma
#12
Dongyun Zhang, Jianwei Ku, Ran Liu, Hongfang Wu, Guina Liang, Yan Wei, Peinan Chen, Xueke Zhao, Song Liu, Yin Li, Jianchao Yao, Xin Song, Lidong Wang
Pre-menopausal female patients have a prolonged survival than post-menopausal patients, indicating that estrogen and/or estrogen receptor (ER) may have some biological effects on prognosis. ER expression in cancer tissue has been reported to be a significant prognostic marker in multiple human cancers. However, the prognostic value of estrogen and/or ER on female patients with esophageal squamous cell carcinoma (ESCC) is rarely reported. The present study was undertaken to elucidate the associations of serum estradiol level, tissue estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) expression with clinical response and reproductive factor changes in 387 female ESCC patients...
July 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28724187/nasogastric-tube-as-abdominal-pressure-sensor-in-urodynamics-proof-of-concept-of-a-novel-approach
#13
Sundaramoorthy VijayGanapathy, Vilvapathy Senguttuvan Karthikeyan, Ashwin Mallya, Ali Poonawala, Ramaiah Keshavamurthy
AIMS: The standard sensor for abdominal pressure (Pabd) measurement in urodynamics (UD) is a rectal sensor. In patients where the rectum is not available due to prior surgery or when external anal sphincter (EAS) tone is poor, rectal sensor may slip, making Pabd recording unreliable. Vaginal Pabd measurement and wireless vaginal sensors have been tried. We present our preliminary series of a novel nasogastric tube (NG) sensor for Pabd measurement. METHODS: We identified patients undergoing UD with a NG Pabd sensor from a prospectively maintained UD database of a tertiary care urological center between July 2013 and December 2016...
July 19, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28724177/natural-molecules-for-the-therapy-of-hyperandrogenism-and-metabolic-disorders-in-pcos
#14
V Cappelli, M C Musacchio, A Bulfoni, G Morgante, V De Leo
OBJECTIVE: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy of women of reproductive age and a complex endocrine condition, due to its heterogeneity and uncertainty about its etiology. However, PCOS is also associated with other metabolic abnormalities such as insulin resistance, impaired glucose tolerance, and diabetes. There are few medications that are approved for the most common symptoms of PCOS, leading to the off-label use of medications that were approved for other indications...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28724172/favorable-effects-of-myo-inositol-selenomethionine-or-their-combination-on-the-hydrogen-peroxide-induced-oxidative-stress-of-peripheral-mononuclear-cells-from-patients-with-hashimoto-s-thyroiditis-preliminary-in-vitro-studies
#15
S Benvenga, T Vicchio, F Di Bari, R Vita, P Fallahi, S M Ferrari, S Catania, C Costa, A Antonelli
OBJECTIVE: The aim of this study was to assess whether blood mononuclear cells (PBMC) from Hashimoto's thyroiditis (HT) and control women, were protected from in vitro H2O2-induced oxidative stress after addition of antioxidants. PATIENTS AND METHODS: PBMC, from 8 HT women and 3 healthy women (controls), were cultured in the presence of 200 µM H2O2 alone, with subsequent addition of myo-inositol (Myo) (0.25, 0.5, 1.0 µM), selenomethionine (SelMet) (0.25, 0.5, 1...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28724170/circulating-insulin-like-growth-factor-1-and-insulin-like-growth-factor-binding-protein-3-predict-three-months-outcome-after-ischemic-stroke
#16
Moritz Armbrust, Hans Worthmann, Reinhard Dengler, Helmut Schumacher, Ralf Lichtinghagen, Christoph Cyrill Eschenfelder, Matthias Endres, Martin Ebinger
Reports on neuroprotective effects of Insulin-like growth factor-1 (IGF-1) and Insulin-like growth factor binding protein-3 (IGFBP-3) in ischemic brain tissue are inconsistent. The aim of this study was to determine if plasma levels of IGF-1 and IGFBP-3 in acute stroke patients are indicative of 3 months functional outcome. Plasma levels were measured via chemiluminescence immunoassay in heparin blood samples of patients included in the EARLY trial (NCT00562588). Plasma samples were drawn on admission and 8 days post-stroke...
July 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28724165/cytogenotoxicity-of-inclusion-complexes-of-diazepam-with-2-hydroxypropyl-%C3%AE-cyclodextrin
#17
Jasmina Hadžiabdić, Nevenka Kopjar, Davor Želježić, Selma Špirtović-Halilović, Davorka Završnik
Background Diazepam, as one of the most frequent prescribed drug from 1,4-benzodiazepine group, has certain limitations in pharmaceutical technology due to its poor solubility in water. By forming inclusion complexes with 2-hydroxypropyl-β-cyclodextrin, diazepam's biopharmaceutical properties can be greatly improved. Aim Aim of this research was to in vitro evaluate genotoxicity of prepared novel complexes of diazepam and their influence on proliferation of human peripheral blood lymphocytes. Methods For identification of possible genotoxicity of diazepam inclusion complexes, cytokinesis-block micronucleus assay has been chosen...
July 19, 2017: Drug Research
https://www.readbyqxmd.com/read/28724148/integrative-medicine-in-residency-feasibility-and-effectiveness-of-an-online-program
#18
Patricia Lebensohn, Benjamin Kligler, Audrey J Brooks, Raymond Teets, Michele Birch, Paula Cook, Victoria Maizes
BACKGROUND AND OBJECTIVES: Online curricular interventions in residency have been proposed to address challenges of time, cost, and curriculum consistency. This study is designed to determine the feasibility and effectiveness of a longitudinal, multisite online curriculum in integrative medicine (IMR) for residents. METHODS: Residents from eight family medicine programs undertook the 200-hour online IMR curriculum. Their medical knowledge (MK) scores at completion were compared to a control group from four similar residency programs...
July 2017: Family Medicine
https://www.readbyqxmd.com/read/28724142/the-aging-physician-and-the-medical-profession-a-review
#19
E Patchen Dellinger, Carlos A Pellegrini, Thomas H Gallagher
Importance: The issue of the aging physician and when to cease practice has been controversial for many years. There are reports of prominent physicians who practiced after becoming dangerous in old age, but the profession has not demonstrated the ability to prevent this. A mandatory retirement age could be discriminatory and take many competent physicians out of practice and risk a physician shortage. An increasing body of evidence regarding the relationship between physicians' age and performance has led organizations, such as the American College of Surgeons, to revisit this challenge...
July 19, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28724122/association-between-patient-age-and-lymph-node-positivity-in-thin-melanoma
#20
Andrew J Sinnamon, Madalyn G Neuwirth, Pratyusha Yalamanchi, Phyllis Gimotty, David E Elder, Xiaowei Xu, Rachel R Kelz, Robert E Roses, Emily Y Chu, Michael E Ming, Douglas L Fraker, Giorgos C Karakousis
Importance: More than half of all new melanoma diagnoses present as clinically localized T1 melanoma, yet sentinel lymph node biopsy (SLNB) is controversial in this population given the overall low yield. Guidelines for SLNB have focused on pathologic factors, but patient factors, such as age, are not routinely considered. Objectives: To identify indicators of lymph node (LN) metastasis in thin melanoma in a large, generalizable data set and to evaluate the association between patient age and LN positivity...
July 19, 2017: JAMA Dermatology
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