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https://www.readbyqxmd.com/read/28806863/influence-of-gender-working-field-and-psychosocial-factors-on-the-vulnerability-for-burnout-in-mental-hospital-staff-results-of-an-austrian-cross-sectional-study
#1
Petra Schadenhofer, Michael Kundi, Heidemarie Abrahamian, Harald Stummer, Alexandra Kautzky-Willer
INTRODUCTION: According to the European Agency for Safety and Health at Work (EU-OSHA), hospitals represent a work environment with high job strain. Prolonged perceived occupational stress may result in symptoms of burnout, such as emotional exhaustion (EE), depersonalisation (DP) and reduced personal accomplishment (PA). Understanding which factors may reduce vulnerability for burnout is an important requirement for well-targeted occupational stress prevention in mental hospital staff...
August 14, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28806845/-effectivity-of-inpatient-psychosomatic-treatment-results-of-a-naturalistic-two-year-survey-in-a-psychosomatic-service-at-a-general-hospital
#2
Juan Valdés-Stauber, Alexander Fuchs, Sören Reiner, Susanne Bachthaler
Background Hospital psychosomatic treatment matches care expectations of a modern society. Evidence of its effectiveness through investigation in different settings is of importance because of prominent role of psychotherapy in German Healthcare System. Objective First, to explore whether clinical as well as personal resources could improve significantly due to a hospital psychosomatic treatment. Second, to assess possible associations between outcome variables and other variables from the multidimensional profile of the sample...
August 14, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28806831/clinical-sign-for-missed-decompression-of-a-separate-extensor-pollicis-brevis-compartment-in-de-quervain-s-disease
#3
Niels Benatar
Persistent pain despite previous surgery for de Quervain's disease might be due to an overlooked septum between the abductor pollicis longus tendon slips and the extensor pollicis brevis tendon, or an overlooked completely separate compartment for the extensor pollicis brevis tendon alone. In both of these instances, extension of the MP joint of the thumb against resistance elicits pain at the distal level of the first extensor compartment of the wrist. When this sign is positive, revisional surgery and decompression of the remaining septum or separate compartment is indicated...
August 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/28806825/-completeness-and-reproducibility-of-surgical-reports-a%C3%A2-retrospective-analysis-of-documentation-quality-using-the-example-of-dupuytren-s-disease
#4
Elisabeth Russe, Andrea Wenger, Gottfried Wechselberger, Hildegunde Piza-Katzer
Background A surgical report is the surgeon's postoperative documentation of the procedure undertaken. The purpose of this study was to evaluate the completeness and accuracy of data extracted from surgical reports, using the example of Dupuytren's disease. Material and Methods Between 1999 and 2007, surgical data were retrospectively collected from all primary Dupuytren's disease procedures performed at an academic department for plastic and reconstructive surgery and analysed for completeness. A surgical report was assessed as complete if data on indication, affected side and finger(s), tourniquet, type of incision and surgical procedure were stated...
August 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/28806819/indicators-of-dysphagia-in-aged-care-facilities
#5
Dai Pu, Thomas Murry, May C M Wong, Edwin M L Yiu, Karen M K Chan
Purpose: The current cross-sectional study aimed to investigate risk factors for dysphagia in elderly individuals in aged care facilities. Method: A total of 878 individuals from 42 aged care facilities were recruited for this study. The dependent outcome was speech therapist-determined swallowing function. Independent factors were Eating Assessment Tool score, oral motor assessment score, Mini-Mental State Examination, medical history, and various functional status ratings...
August 14, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28806765/pka-activity-is-essential-for-relieving-the-suppression-of-hyphal-growth-and-appressorium-formation-by-mosfl1-in-magnaporthe-oryzae
#6
Yang Li, Xue Zhang, Shuai Hu, Huiquan Liu, Jin-Rong Xu
In the rice blast fungus Magnaporthe oryzae, the cAMP-PKA pathway regulates surface recognition, appressorium turgor generation, and invasive growth. However, deletion of CPKA failed to block appressorium formation and responses to exogenous cAMP. In this study, we generated and characterized the cpk2 and cpkA cpk2 mutants and spontaneous suppressors of cpkA cpk2 in M. oryzae. Our results demonstrate that CPKA and CPK2 have specific and overlapping functions, and PKA activity is essential for appressorium formation and plant infection...
August 14, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28806760/endothelial-activation-and-dysfunction-in-severe-fever-with-thrombocytopenia-syndrome
#7
Xiao-Kun Li, Zhen-Dong Yang, Juan Du, Bo Xing, Ning Cui, Pan-He Zhang, Hao Li, Xiao-Ai Zhang, Qing-Bin Lu, Wei Liu
BACKGROUND: Pathogenesis of severe fever with thrombocytopenia syndrome (SFTS) has not been well described yet. Recent studies indicate that SFTSV could replicate in endothelial cells. Here we performed a case-control study to determine whether endothelial activation/dysfunction occurred in SFTSV infection and to identify the biomarkers reflecting endothelial dysfunction. METHODOLOGY/PRINCIPAL FINDINGS: In a case-control study of 134 SFTS patients and 68 healthy controls, serum levels of plasminogen activator inhibitor 1, tissue plasminogen activator, P-selectin, platelet endothelial cell adhesion molecular, CD40 ligand, E-selectin, vascular endothelial growth factor A, serum amyloid antigen 1 (SAA-1) and vascular cell adhesion molecular 1 were significantly enhanced in the patients than the controls (all P<0...
August 14, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28806758/developmental-vascular-remodeling-defects-and-postnatal-kidney-failure-in-mice-lacking-gpr116-adgrf5-and-eltd1-adgrl4
#8
Shun Lu, Shuya Liu, Astrid Wietelmann, Baktybek Kojonazarov, Ann Atzberger, Cong Tang, Ralph Theo Schermuly, Hermann-Josef Gröne, Stefan Offermanns
GPR116 (ADGRF5) and ELTD1 (ADGRL4) belong to different subfamilies of the adhesion G-protein-coupled receptor group but are both expressed in endothelial cells. We therefore analyzed their functions in mice lacking these receptors. While loss of GPR116 or ELTD1 alone had no obvious effect on cardiovascular or kidney function, mice lacking both, GPR116 and ELTD1, showed malformations of the aortic arch arteries and the cardiac outflow tract leading to perinatal lethality in about 50% of the mutants. In addition to cardiovascular malformations, surviving mice developed renal thrombotic microangiopathy as well as hemolysis and splenomegaly, and their lifespan was significantly reduced...
2017: PloS One
https://www.readbyqxmd.com/read/28806757/impact-of-interaction-style-and-degree-on-the-evolution-of-cooperation-on-barab%C3%A3-si-albert-scale-free-network
#9
Fengjie Xie, Jing Shi, Jun Lin
In this work, we study an evolutionary prisoner's dilemma game (PDG) on Barabási-Albert scale-free networks with limited player interactions, and explore the effect of interaction style and degree on cooperation. The results show that high-degree preference interaction, namely the most applicable interaction in the real world, is less beneficial for emergence of cooperation on scale-free networks than random interaction. Besides, cooperation on scale-free networks is enhanced with the increase of interaction degree regardless whether the interaction is high-degree preference or random...
2017: PloS One
https://www.readbyqxmd.com/read/28806755/acquired-von-willebrand-syndrome-in-cardiogenic-shock-patients-on-mechanical-circulatory-microaxial-pump-support
#10
Ulrike Flierl, Jörn Tongers, Dominik Berliner, Jan-Thorben Sieweke, Florian Zauner, Christoph Wingert, Christian Riehle, Johann Bauersachs, Andreas Schäfer
Early use of mechanical circulatory support, e.g. veno-arterial extracorporeal membrane oxygenation (ECMO) or left ventricular unloading by microaxial pump in refractory cardiogenic shock is recommended in current guidelines. Development of acquired von Willebrand Syndrome (AVWS) in patients with left ventricular assist devices (LVADs) and ECMO has been reported. There is an increasing number of patients treated with the Impella® CP microaxial pump for left ventricular unloading. However, the prevalence of AVWS in these high risk patients is unknown and needs to be determined...
2017: PloS One
https://www.readbyqxmd.com/read/28806748/temperature-effects-on-gene-expression-and-morphological-development-of-european-eel-anguilla-anguilla-larvae
#11
Sebastian N Politis, David Mazurais, Arianna Servili, Jose-Luis Zambonino-Infante, Joanna J Miest, Sune R Sørensen, Jonna Tomkiewicz, Ian A E Butts
Temperature is important for optimization of rearing conditions in aquaculture, especially during the critical early life history stages of fish. Here, we experimentally investigated the impact of temperature (16, 18, 20, 22 and 24°C) on thermally induced phenotypic variability, from larval hatch to first-feeding, and the linked expression of targeted genes [heat shock proteins (hsp), growth hormone (gh) and insulin-like growth factors (igf)] associated to larval performance of European eel, Anguilla anguilla...
2017: PloS One
https://www.readbyqxmd.com/read/28806746/selective-small-chemical-inhibitors-of-protein-arginine-methyltransferase-5-with-anti-lung-cancer-activity
#12
Gui-Mei Kong, Min Yu, Zhongping Gu, Zhi Chen, Rui-Ming Xu, Deon O'Bryant, Zhengxin Wang
Protein arginine methyltransferase 5 (PRMT5) plays critical roles in a wide variety of biological processes, including tumorigenesis. By screening a library of small chemical compounds, we identified eight compounds that selectively inhibit the PRMT5 enzymatic activity, with IC50 values ranging from 0.1 to 6 μM. Molecular docking simulation and site-directed mutagenesis indicated that identified compounds target the substrate-binding site in PRMT5. Treatment of lung cancer cells with identified inhibitors led to inhibition of the symmetrical arginine methylation of SmD3 and histones and the cellular proliferation...
2017: PloS One
https://www.readbyqxmd.com/read/28806742/dissociating-maternal-responses-to-sad-and-happy-facial-expressions-of-their-own-child-an-fmri-study
#13
Dorothea Kluczniok, Catherine Hindi Attar, Jenny Stein, Sina Poppinga, Thomas Fydrich, Charlotte Jaite, Viola Kappel, Romuald Brunner, Sabine C Herpertz, Katja Boedeker, Felix Bermpohl
BACKGROUND: Maternal sensitive behavior depends on recognizing one's own child's affective states. The present study investigated distinct and overlapping neural responses of mothers to sad and happy facial expressions of their own child (in comparison to facial expressions of an unfamiliar child). METHODS: We used functional MRI to measure dissociable and overlapping activation patterns in 27 healthy mothers in response to happy, neutral and sad facial expressions of their own school-aged child and a gender- and age-matched unfamiliar child...
2017: PloS One
https://www.readbyqxmd.com/read/28806739/combined-effects-of-o3-and-uv-radiation-on-secondary-metabolites-and-endogenous-hormones-of-soybean-leaves
#14
Bing Mao, Hong Yin, Yan Wang, Tian-Hong Zhao, Rong-Rong Tian, Wei Wang, Jia-Shu Ye
Enhanced ultraviolet radiation (UV) and elevated tropospheric ozone (O3) may individually cause reductions in the growth and productivity of important agricultural crops. However, research regarding their combined effects on important agricultural crops is still scarce, especially on changes in secondary metabolites and endogenous hormones, which are important protective substances and signal components that control plant responses to environment stresses. In this study, using an experimental setup of open top chambers, we monitored the responses of seed yield per plant, leaf secondary metabolites and leaf endogenous hormones under the stress of elevated O3 and enhanced UV radiation individually, as well as their combined stress...
2017: PloS One
https://www.readbyqxmd.com/read/28806731/climatic-niche-of-selinum-alatum-apiaceae-selineae-a-new-invasive-plant-species-in-central-europe-and-its-alterations-according-to-the-climate-change-scenarios-are-the-european-mountains-threatened-by-invasion
#15
Kamil Konowalik, Małgorzata Proćków, Jarosław Proćków
In recent years, a few established populations of Selinum alatum have been found in the Eastern Carpathians outside its native range that is the Caucasus and the Armenian Highlands. The species is spreading predominantly in Poland where it can outcompete native plants in certain cases. This study addresses a potential climatic niche of the plant with the special aims to illuminate future spreading and indicate areas suitable for invasion. Our results show that the extent of the favourable habitat of the species is broader than currently known...
2017: PloS One
https://www.readbyqxmd.com/read/28806729/erk2-and-jnk1-contribute-to-tnf-%C3%AE-induced-il-8-expression-in-synovial-fibroblasts
#16
Shinichi Namba, Rei Nakano, Taku Kitanaka, Nanako Kitanaka, Tomohiro Nakayama, Hiroshi Sugiya
Tumor necrosis factor α (TNF-α) induces the expression and secretion of interleukin 8 (IL-8), which contributes to synovitis in rheumatoid arthritis (RA). To elucidate the mechanism of the onset of RA, we used synovial fibroblasts without autoimmune inflammatory diseases and investigated MAPK signaling pathways in TNF-α-induced IL-8 expression. Synovial fibroblasts isolated from healthy dogs were characterized by flow cytometry, which were positive for the fibroblast markers CD29, CD44, and CD90 but negative for the hematopoietic cell markers CD14, CD34, CD45, and HLA-DR...
2017: PloS One
https://www.readbyqxmd.com/read/28806724/one-star-rating-for-a-five-star-program-evaluating-hospital-compare
#17
J M Shapiro
OBJECTIVES: For healthcare systems of any size, it is important to minimize costs while maximizing outcomes. One idea of how to achieve these goals has been the reduction in hospital-related complications, including infection and surgical complications, among others. In the United States, policy makers recently adopted the 'Hospital Compare' program as a way to encourage consumers and improve hospitals. This article evaluates the effectiveness of this policy. STUDY DESIGN: This article uses an observed cohort study of most US hospitals across four different indices...
August 11, 2017: Public Health
https://www.readbyqxmd.com/read/28806722/spontaneous-modality-general-abstraction-of-a-ratio-scale
#18
Cory D Bonn, Jessica F Cantlon
The existence of a generalized magnitude system in the human mind and brain has been studied extensively but remains elusive because it has not been clearly defined. Here we show that one possibility is the representation of relative magnitudes via ratio calculations: ratios are a naturally dimensionless or abstract quantity that could qualify as a common currency for magnitudes measured on vastly different psychophysical scales and in different sensory modalities like size, number, duration, and loudness. In a series of demonstrations based on comparisons of item sequences, we demonstrate that subjects spontaneously use knowledge of inter-item ratios within and across sensory modalities and across magnitude domains to rate sequences as more or less similar on a sliding scale...
August 11, 2017: Cognition
https://www.readbyqxmd.com/read/28806719/comparison-of-reactive-oxygen-species-metabolism-during-grape-berry-development-between-kyoho-and-its-early-ripening-bud-mutant-fengzao
#19
Fei-Fei Xi, Li-Li Guo, Yi-He Yu, Yan Wang, Qiong Li, Hui-Li Zhao, Guo-Hai Zhang, Da-Long Guo
Enzymes and non-enzyme elements related to the metabolism of reactive oxygen species (ROS), such as catalase (CAT), superoxide dismutase (SOD), ascorbic acid (AsA), glutathione (GSH), NADPH oxidase (NOX), hydrogen peroxide (H2O2), superoxide anion (O2(-)), lipoxygenase (LOX) and malondialdehyde (MDA), were measured in 'Kyoho' and its early ripening bud mutant 'Fengzao' to compare ROS level changes and investigate the potential roles of ROS in grape berry development and the ripening process. In addition, the anthocyanin and sugar contents as well as berry diameter were also investigated at different berry development stages...
August 9, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28806705/multiparametric-monitoring-of-microbial-faecal-pollution-reveals-the-dominance-of-human-contamination-along-the-whole-danube-river
#20
A K T Kirschner, G H Reischer, S Jakwerth, D Savio, S Ixenmaier, E Toth, R Sommer, R L Mach, R Linke, A Eiler, S Kolarevic, A H Farnleitner
The microbial faecal pollution of rivers has wide-ranging impacts on a variety of human activities that rely on appropriate river water quality. Thus, detailed knowledge of the extent and origin of microbial faecal pollution is crucial for watershed management activities to maintain safe water use. In this study, the microbial faecal pollution levels were monitored by standard faecal indicator bacteria (SFIB) along a 2580 km stretch of the Danube, the world's most international river, as well as the Danube's most important tributaries...
July 22, 2017: Water Research
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