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https://www.readbyqxmd.com/read/29345963/deletion-of-estrogen-receptor-alpha-in-skeletal-muscle-results-in-impaired-contractility-in-female-mice
#1
Brittany C Collins, Tara L Mader, Christine A Cabelka, Melissa R Iñigo, Espen E Spangenburg, Dawn A Lowe
Estradiol deficiency in females can result in skeletal muscle strength loss, and treatment with estradiol mitigates the loss. There are three primary estrogen receptors and estradiol elicits effects through these receptors in various tissues. Ubiquitous estrogen receptor α (ERα) knockout mice exhibit numerous biological disorders, but little is known regarding the specific role of ERα in skeletal muscle contractile function. The purpose of this study was to determine the impact of skeletal muscle specific ERα deletion on contractile function, hypothesizing that ERα is a main receptor through which estradiol affects muscle strength in females...
January 18, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29315676/aging-impairs-regulation-of-ryanodine-receptors-from-edl-but-not-soleus-muscles
#2
Angela J Gaboardi, Jochen Kressler, Teresa K Snow, Edward M Balog
INTRODUCTION: Because impaired excitation-contraction coupling and reduced sarcoplasmic reticulum Ca2+ release may contribute to the age-associated decline in skeletal muscle strength, we investigated the effect of aging on RyR1 regulation by physiological channel ligands. METHODS: [3 H]Ryanodine binding to membranes from 8 and 26 month old Fischer 344 extensor digitorum longus (EDL) and soleus muscles was used to investigate the effects of age on RyR1 modulation by Ca2+ and calmodulin (CaM)...
January 9, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29297989/increased-temperature-accelerates-glycogen-synthesis-and-delays-fatigue-in-isolated-mouse-muscle-during-repeated-contractions
#3
Ester Hanya, Abram Katz
AIM: Elevated glycogen content in muscle delays fatigue during exercise. We examined if increasing muscle temperature during recovery from exercise affects glycogen synthesis and muscle performance during a subsequent bout of exercise. METHODS: Isolated mouse extensor digitorum longus muscles were stimulated electrically to perform repeated tetanic contractions until force decreased to 40% of initial at 25°C. Thereafter muscles recovered for 120 min at 25°C (control), 120 min at 35°C, or 60 min at 35°C followed by 60 min at 25°C...
January 3, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29277489/c-547-a-6-methyluracil-derivative-with-long-lasting-binding-and-rebinding-on-acetylcholinesterase-pharmacokinetic-and-pharmacodynamic-studies
#4
Konstantin Petrov, Irina Zueva, Irina Kovyazina, Igor Sedov, Sofya Lushchekina, Alexandra Kharlamova, Oksana Lenina, Sergei Koshkin, Yurii Shtyrlin, Evgeny Nikolsky, Patrick Masson
C-547, a potent slow-binding inhibitor of acetylcholinesterase (AChE) was intravenously administered to rat (0.05 mg/kg). Pharmacokinetic profiles were determined in blood and different organs: extensor digitorum longus muscle, heart, liver, lungs and kidneys as a function of time. Pharmacokinetics (PK) was studied using non-compartmental and compartmental analyses. A 3-compartment model describes PK in blood. Most of injected C-547 binds to albumin in the bloodstream. The steady-state volume of distribution (3800 ml/kg) is 15 times larger than the distribution volume, indicating a good tissue distribution...
December 24, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29236945/the-effect-of-increasing-age-on-the-concentric-and-eccentric-contractile-properties-of-isolated-mouse-soleus-and-extensor-digitorum-longus-muscles
#5
Cameron Hill, Rob S James, Val M Cox, Jason Tallis
There is currently a limited amount of literature investigating the age-related changes in eccentric muscle function in vitro. The present study uniquely uses the work loop technique, to better replicate in vivo muscle function, in the assessment of the age and muscle-specific changes in acute and sustained concentric and eccentric power and recovery. Whole soleus or EDL muscles were isolated from 10-week and 78-week old mice, and acute and sustained concentric and eccentric work loop power assessed. Despite an age-related increase in body and muscle mass, peak absolute power for both muscles was unaffected by age...
December 9, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29234703/lean-and-obese-zucker-rat-extensor-digitorum-longus-muscle-high-frequency-electrical-stimulation-hfes-data-regulation-of-p70s6kinase-associated-proteins
#6
Kevin M Rice, Anjaiah Katta, Nandini D P K Manne, Ravikumar Arvapalli, Gautam K Ginjupalli, Miaozong Wu, Shinichi Asano, Eric R Blough
Anaerobic exercise has been advocated as a prescribed treatment for the management of diabetes: however, alterations in exercise-induced signaling remain largely unexplored in the diabetic muscle. Here, we compare the basal and the in situ contraction-induced phosphorylation of the AKT, GSK3beta, mTor, p70s6K, Pten, and Shp2 in the lean and obese (fa/fa) Zucker rat Extensor Digitorum Longus (EDL) muscle following a single bout of contractile stimuli. This article represents data associated with prior publications from our lab (Katta et al...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29234693/lean-and-obese-zucker-rat-extensor-digitorum-longus-muscle-high-frequency-electrical-stimulation-hfes-data-regulation-of-mapks-associated-proteins
#7
Kevin M Rice, Anjaiah Katta, Nandini D P K Manne, Ravikumar Arvapalli, Gautam K Ginjupalli, Miaozong Wu, Shinichi Asano, Eric R Blough
Anaerobic exercise has been advocated as a prescribed treatment for the management of diabetes: however, alterations in exercise-induced signaling remain largely unexplored in the diabetic muscle. Here, we compare the basal and the in situ contraction-induced phosphorylation of the mitogen-activated protein kinases (MAPKs) ERK 1/2, p38, and JNK in the lean and obese (fa/fa) Zucker rat extensor digitorum longus (EDL) muscle following a single bout of contractile stimuli. This article represents data associated with prior publications from our (Katta et al...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29204135/recombinant-uncarboxylated-osteocalcin-per-se-enhances-mouse-skeletal-muscle-glucose-uptake-in-both-extensor-digitorum-longus-and-soleus-muscles
#8
Xuzhu Lin, Lewan Parker, Emma Mclennan, Xinmei Zhang, Alan Hayes, Glenn McConell, Tara C Brennan-Speranza, Itamar Levinger
Emerging evidence suggests that undercarboxylated osteocalcin (ucOC) improves muscle glucose uptake in rodents. However, whether ucOC can directly increase glucose uptake in both glycolytic and oxidative muscles and the possible mechanisms of action still need further exploration. We tested the hypothesis that ucOC per se stimulates muscle glucose uptake via extracellular signal-regulated kinase (ERK), adenosine monophosphate-activated protein kinase (AMPK), and/or the mechanistic target of rapamycin complex 2 (mTORC2)-protein kinase B (AKT)-AKT substrate of 160 kDa (AS160) signaling cascade...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29185588/fasting-a-major-limitation-for-resistance-exercise-training-effects-in-rodents
#9
W das Neves, L F de Oliveira, R P da Silva, C R R Alves, A H Lancha
Protocols that mimic resistance exercise training (RET) in rodents present several limitations, one of them being the electrical stimulus, which is beyond the physiological context observed in humans. Recently, our group developed a conditioning system device that does not use electric shock to stimulate rats, but includes fasting periods before each RET session. The current study was designed to test whether cumulative fasting periods have some influence on skeletal muscle mass and function. Three sets of male Wistar rats were used in the current study...
November 17, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29185184/changes-in-contractile-and-metabolic-parameters-of-skeletal-muscle-as-rats-age-from-3-to-12-months
#10
Hongyang Xu, Graham D Lamb, Robyn M Murphy
Laboratory rats are considered mature at 3 months despite that musculoskeletal growth is still occurring. Changes in muscle physiological and biochemical characteristics during development from 3 months, however, are not well understood. Whole muscles and single skinned fibres from fast-twitch extensor digitorum longus (EDL) and predominantly slow-twitch soleus (SOL) muscles were examined from male Sprague-Dawley rats (3, 6, 9, 12 months). Ca2+ sensitivity of contractile apparatus decreased with age in both fast- (~ 0...
November 28, 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/29184265/long-term-low-intensity-endurance-exercise-along-with-blood-flow-restriction-improves-muscle-mass-and-neuromuscular-junction-compartments-in-old-rats
#11
Mohammad-Ali Bahreini Pour, Siyavash Joukar, Fariborz Hovanloo, Hamid Najafipour
Background: During the aging process, muscle atrophy and neuromuscular junction remodeling are inevitable. The present study aimed to clarify whether low-intensity aerobic exercise along with limb blood-flow restriction (BFR) could improve aging-induced muscle atrophy and nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. Methods: Forty-eight male Wistar rats, aged 23-24 months, were randomly divided into control, sham (Sh: subjected to surgery without BFR), BFR (subjected to BFR), exercise (Ex: subjected to 10 weeks of low-intensity exercise), Sh+Ex, and BFR+Ex groups...
November 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29173208/dietary-supplementation-with-cysteine-prevents-adverse-metabolic-outcomes-of-repeated-cures-with-paracetamol-in-old-rats
#12
Carole Mast, Charlène Pourpe, Guillaume Voyard, Didier Rémond, Carole Migné, Delphine Centeno, Dominique Dardevet, Isabelle Savary-Auzeloux, Isabelle Papet
Cysteine (Cys), a conditionally indispensable amino acid, is required for the detoxification of paracetamol (acetaminophen, N-acetyl-para-aminophenol, 4-hydroxy-acetanilide, APAP), a drug of widespread use in older persons. We recently reported that repeated APAP cures could worsen sarcopenia in old rats, likely to be due to the impairment of Cys/GSH homoeostasis. The aim of the study was to evaluate whether a dietary Cys supplementation during APAP cures could improve Cys/GSH homoeostasis and thus preserve skeletal muscle...
December 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29166705/comprehensive-analysis-of-nine-monoamines-and-metabolites-in-small-amounts-of-peripheral-murine-c57bl-6j-tissues
#13
Joachim Nagler, Sonja C Schriever, Meri De Angelis, Paul T Pfluger, Karl-Werner Schramm
Monoamines, acting as hormones and neurotransmitters, play a critical role in multiple physiological processes ranging from cognitive function and mood to sympathetic nervous system activity, fight-or-flight response, or glucose homeostasis. In addition to brain and blood, monoamines are abundant in several tissues, and dysfunction in their synthesis or signaling is associated with various pathological conditions. It was our goal to develop a method to detect these compounds in peripheral murine tissues. In this study, we employed a high performance liquid chromatography method using electrochemical detection that allows not only detecting the catecholamines but a detailed analysis of nine monoamines and metabolites in murine tissues...
November 22, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29163473/treadmill-slope-modulates-inflammation-fiber-type-composition-androgen-and-glucocorticoid-receptors-in-the-skeletal-muscle-of-overtrained-mice
#14
Alisson L da Rocha, Bruno C Pereira, Giovana R Teixeira, Ana P Pinto, Fabiani G Frantz, Lucila L K Elias, Fábio S Lira, José R Pauli, Dennys E Cintra, Eduardo R Ropelle, Leandro P de Moura, Rania A Mekary, Ellen C de Freitas, Adelino S R da Silva
Overtraining (OT) may be defined as an imbalance between excessive training and adequate recovery period. Recently, a downhill running-based overtraining (OTR/down) protocol induced the nonfunctional overreaching state, which is defined as a performance decrement that may be associated with psychological and hormonal disruptions and promoted intramuscular and systemic inflammation. To discriminate the eccentric contraction effects on interleukin 1beta (IL-1β), IL-6, IL-10, IL-15, and SOCS-3, we compared the release of these cytokines in OTR/down with other two OT protocols with the same external load (i...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29137485/heat-stress-prevents-the-decrease-in-succinate-dehydrogenase-activity-in-the-extensor-digitorum-longus-of-streptozotocin-induced-diabetic-rats
#15
K Nonaka, S Une, M Komatsu, R Yamaji, J Akiyama
This study aimed to investigate whether heat stress (HS) prevents a decrease in succinate dehydrogenase (SDH) activity and heat shock protein 60 (HSP60) and superoxide dismutase 2 (SOD2) contents in the extensor digitorum longus of streptozotocin (STZ)-induced diabetic rats. Twelve-week-old male Wistar rats were assigned to one of the four groups (n=6/group): control (Con), HS, diabetes mellitus (DM), and diabetes mellitus and heat stress (DM+HS). Diabetes was induced by the administration of STZ (50 mg/kg)...
November 10, 2017: Physiological Research
https://www.readbyqxmd.com/read/29133865/cold-acclimation-causes-fiber-type-specific-responses-in-glucose-and-fat-metabolism-in-rat-skeletal-muscles
#16
Diane M Sepa-Kishi, Yass Sotoudeh-Nia, Ayesha Iqbal, George Bikopoulos, Rolando B Ceddia
This study investigated fiber type-specific metabolic responses and the molecular mechanisms that regulate glucose and fat metabolism in oxidative and glycolytic muscles upon cold acclimation. Male Wistar rats were exposed to cold (4 °C) for 7 days, and then glycogen synthesis and content, glucose and palmitate oxidation, and the molecular mechanisms underlying these metabolic pathways were assessed in soleus (Sol), extensor digitorum longus (EDL), and epitrochlearis (Epit) muscles. Cold acclimation increased glycogen synthesis, glycogen content, glucose oxidation, and reduced glycogen synthase (GS) phosphorylation only in Sol muscles...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29125130/acid-sphingomyelinase-inhibitors-imipramine-and-zoledronic-acid-increase-skeletal-muscle-tissue-sensitivity-to-insulin-action-at-old-age
#17
Loay Kh M Hassouneh, Olga A Timofiychuk, Nataliya A Babenko
Malfunction of skeletal muscles and dysregulated turnover of sphingolipids in the insulin responsive tissues have been determined at old age. Present article investigates the role of acid sphingomyelinase (SMase)-dependent ceramide accumulation in reduction of the skeletal muscle sensitivity to insulin action at old age. The 3-, 12- and 24-month-old Wistar male rats were used in the experiments. The progressive increase of ceramide content and ceramide/sphingomyeline (SM) ratio was determined in the extensor digitorum longus (EDL) muscle during aging of rats...
November 10, 2017: General Physiology and Biophysics
https://www.readbyqxmd.com/read/29122950/myosin-phosphorylation-potentiated-steady-state-work-output-without-altering-contractile-economy-of-mouse-fast-skeletal-muscles
#18
William Gittings, Jordan Bunda, Rene Vandenboom
Skeletal myosin light chain kinase (skMLCK) catalyzed phosphorylation of the myosin regulatory light chain (RLC) increases (i.e. potentiates) mechanical work output of fast skeletal muscle. The influence of this event on contractile economy (i.e. energy cost/work performed) remains controversial, however. Our purpose was to quantify contractile economy of potentiated extensor digitorum longus (EDL) muscles from mouse skeletal muscles with (wildtype, WT) and without (skMLCK ablated, skMLCK(-/-)) the ability to phosphorylate the RLC...
November 9, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29121992/a-mouse-anti-myostatin-antibody-increases-muscle-mass-and-improves-muscle-strength-and-contractility-in-the-mdx-mouse-model-of-duchenne-muscular-dystrophy-and-its-humanized-equivalent-domagrozumab-pf-06252616-increases-muscle-volume-in-cynomolgus-monkeys
#19
Michael St Andre, Mark Johnson, Prashant N Bansal, Jeremy Wellen, Andrew Robertson, Alan Opsahl, Peter M Burch, Peter Bialek, Carl Morris, Jane Owens
BACKGROUND: The treatments currently approved for Duchenne muscular dystrophy (DMD), a progressive skeletal muscle wasting disease, address the needs of only a small proportion of patients resulting in an urgent need for therapies that benefit all patients regardless of the underlying mutation. Myostatin is a member of the transforming growth factor-β (TGF-β) family of ligands and is a negative regulator of skeletal muscle mass. Loss of myostatin has been shown to increase muscle mass and improve muscle function in both normal and dystrophic mice...
November 9, 2017: Skeletal Muscle
https://www.readbyqxmd.com/read/29120354/trans-plasma-membrane-electron-transport-and-ascorbate-efflux-by-skeletal-muscle
#20
Amanda M Eccardt, Thomas P Bell, Lyn Mattathil, Rohan Prasad, Shannon C Kelly, Jonathan S Fisher
Trans-plasma membrane electron transport (tPMET) and the antioxidant roles of ascorbate reportedly play a role in protection of cells from damage by reactive oxygen species, which have been implicated in causing metabolic dysfunction such as insulin resistance. Skeletal muscle comprises the largest whole-body organ fraction suggesting a potential role of tPMET and ascorbate export as a major source of extracellular antioxidant. We hypothesized that skeletal muscle is capable of tPMET and ascorbate efflux. To measure these processes, we assayed the ability of cultured muscle cells, satellite cells, and isolated extensor digitorum longus (EDL) and soleus (SOL) to reduce two extracellular electron acceptors, water soluble tetrazolium salt 1 (WST-1), and dichlorophenolindophenol (DPIP)...
November 9, 2017: Antioxidants (Basel, Switzerland)
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