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extensor digitorum longus

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https://www.readbyqxmd.com/read/27906079/muscle-specific-loss-of-bmal1-leads-to-disrupted-tissue-glucose-metabolism-and-systemic-glucose-homeostasis
#1
Brianna D Harfmann, Elizabeth A Schroder, Maureen T Kachman, Brian A Hodge, Xiping Zhang, Karyn A Esser
BACKGROUND: Diabetes is the seventh leading cause of death in the USA, and disruption of circadian rhythms is gaining recognition as a contributing factor to disease prevalence. This disease is characterized by hyperglycemia and glucose intolerance and symptoms caused by failure to produce and/or respond to insulin. The skeletal muscle is a key insulin-sensitive metabolic tissue, taking up ~80 % of postprandial glucose. To address the role of the skeletal muscle molecular clock to insulin sensitivity and glucose tolerance, we generated an inducible skeletal muscle-specific Bmal1 (-/-) mouse (iMSBmal1 (-/-))...
March 30, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27890461/muscle-weakness-in-respiratory-and-peripheral-skeletal-muscles-in-a-mouse-model-for-nebulin-based-nemaline-myopathy
#2
Barbara Joureau, Josine M de Winter, Kelly Stam, Henk Granzier, Coen A C Ottenheijm
Nemaline myopathy is among the most common non-dystrophic congenital myopathies, and is characterized by the presence of nemaline rods in skeletal muscles fibers, general muscle weakness, and hypotonia. Although respiratory failure is the main cause of death in nemaline myopathy, only little is known regarding the contractile strength of the diaphragm, the main muscle of inspiration. To investigate diaphragm contractility, in the present study we took advantage of a mouse model for nebulin-based nemaline myopathy that we recently developed...
October 25, 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/27884960/can-inorganic-phosphate-explain-sag-during-unfused-tetanic-contractions-of-skeletal-muscle
#3
Ian C Smith, Catherine Bellissimo, Walter Herzog, A Russell Tupling
We test the hypothesis that cytosolic inorganic phosphate (Pi) can account for the contraction-induced reductions in twitch duration which impair summation and cause force to decline (sag) during unfused tetanic contractions of fast-twitch muscle. A five-state model of crossbridge cycling was used to simulate twitch and unfused tetanic contractions. As Pi concentration ([Pi]) was increased from 0 to 30 mmol·L(-1), twitch duration decreased, with progressive reductions in sensitivity to Pi as [Pi] was increased...
November 2016: Physiological Reports
https://www.readbyqxmd.com/read/27870637/calcium-homeostasis-alterations-in-a-mouse-model-of-the-dynamin-2-related-centronuclear-myopathy
#4
Bodvaël Fraysse, Pascale Guicheney, Marc Bitoun
Autosomal dominant centronuclear myopathy (CNM) is a rare congenital myopathy characterized by centrally located nuclei in muscle fibers. CNM results from mutations in the gene encoding dynamin 2 (DNM2), a large GTPase involved in endocytosis, intracellular membrane trafficking, and cytoskeleton regulation. We developed a knock-in mouse model expressing the most frequent DNM2-CNM mutation; i.e. the KI-Dnm2(R465W) model. Heterozygous (HTZ) KI-Dnm2 mice progressively develop muscle atrophy, impairment of contractile properties, histopathological abnormalities, and elevated cytosolic calcium concentration...
November 15, 2016: Biology Open
https://www.readbyqxmd.com/read/27861863/exploring-the-role-of-pgc-1%C3%AE-in-defining-nuclear-organisation-in-skeletal-muscle-fibres
#5
Jacob A Ross, Adam Pearson, Yotam Levy, Bettina Cardel, Christoph Handschin, Julien Ochala
Muscle fibres are multinucleated cells, with each nucleus controlling the protein synthesis in a finite volume of cytoplasm termed the myonuclear domain (MND). What determines MND size remains unclear. In the present study, we aimed to test the hypothesis that the level of expression of the transcriptional coactivator PGC-1α and subsequent activation of the mitochondrial biogenesis are major contributors. Hence, we used two transgenic mouse models with varying expression of PGC-1α in skeletal muscles. We isolated myofibres from the fast twitch extensor digitorum longus (EDL) and slow twitch diaphragm muscles...
November 7, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27856964/neonatal-satellite-cells-form-small-myotubes-in-vitro
#6
P L Carvajal Monroy, S Grefte, A M Kuijpers-Jagtman, J W Von den Hoff, F A D T G Wagener
Although palatal muscle reconstruction in patients with cleft palate takes place during early childhood, normal speech development is often not achieved. We hypothesized that the intrinsic properties of head satellite cells (SCs) and the young age of these patients contribute to the poor muscle regeneration after surgery. First, we studied the fiber type distribution and the expression of SC markers in ex vivo muscle tissue from head (branchiomeric) and limb (somite-derived) muscles from neonatal (2-wk-old) and young (9-wk-old) rats...
November 16, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27856719/the-effect-of-obesity-on-the-contractile-performance-of-isolated-mouse-soleus-edl-and-diaphragm-muscles
#7
Jason Tallis, Cameron Hill, Rob S James, Val M Cox, Frank Seebacher
Obesity affects the major metabolic and cellular processes involved in skeletal muscle contractility. Surprisingly, the effect of obesity on isolated skeletal muscle performance remains unresolved. The present study is the first to examine the muscle specific changes in contractility following dietary induced obesity using an isolated muscle work-loop (WL) model that more closely represents in vivo muscle performance. Following 16-week high calorific feeding, soleus (SOL), extensor digitorum longus (EDL), and diaphragm (DIA) were isolated from female (CD-1) mice and contractile performance compared against a lean control group...
November 17, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27845481/unilateral-variation-in-extensor-digitorum-longus-muscle
#8
A Banerje, S Singh, K Raza, N Rani, S Kaler
During a routine dissection of an adult embalmed male cadaver for educational purpose in the department of anatomy at AIIMS, New Delhi, India, a rare unilateral variation of extensor digitorum longus (EDL) was found which is a muscle of anterior compartment of the leg. There was a split tendon of EDL muscle in the anterior compartment of left leg which became a common tendon in front of the ankle joint. This common tendon of EDL muscle again divided into four slips and were inserted in to the lateral four toes...
September 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/27822449/similar-efficacy-from-specific-and-non-specific-mineralocorticoid-receptor-antagonist-treatment-of-muscular-dystrophy-mice
#9
Jeovanna Lowe, Kyle T Floyd, Neha Rastogi, Eric J Schultz, Jessica A Chadwick, Sarah A Swager, Jonathan G Zins, Feni K Kadakia, Suzanne Smart, Elise P Gomez-Sanchez, Celso E Gomez-Sanchez, Subha V Raman, Paul M L Janssen, Jill A Rafael-Fortney
BACKGROUND: Combined treatment with an angiotensin-converting enzyme inhibitor and a mineralocorticoid receptor (MR) antagonist improved cardiac and skeletal muscle function and pathology in a mouse model of Duchenne muscular dystrophy. MR is present in limb and respiratory skeletal muscles and functions as a steroid hormone receptor. OBJECTIVE: The goals of the current study were to compare the efficacy of the specific MR antagonist eplerenone with the non-specific MR antagonist spironolactone, both in combination with the angiotensin-converting enzyme inhibitor lisinopril...
2016: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/27822290/dietary-selenium-augments-sarcoplasmic-calcium-release-and-mechanical-performance-in-mice
#10
Dóra Bodnár, Olga Ruzsnavszky, Tamás Oláh, Beatrix Dienes, Ildikó Balatoni, Éva Ungvári, Ilona Benkő, Beáta Babka, József Prokisch, László Csernoch, Péter Szentesi
BACKGROUND: As an essential trace element selenium plays a significant role in many physiological functions of the organs. It is found within muscles as selenocystein in selenoprotein N, which is involved in redox-modulated calcium homeostasis and in protection against oxidative stress. METHODS: The effects of two different selenium compounds (selenate and NanoSe in 0.5 and 5 ppm concentration for two weeks) on muscle properties of mice were examined by measuring in vivo muscle performance, in vitro force in soleus (SOL) and extensor digitorum longus (EDL) muscles and changes in intracellular Ca(2+) concentration in single fibers from flexor digitorum brevis (FDB) muscle...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27820862/fast-to-slow-transition-of-skeletal-muscle-contractile-function-and-corresponding-changes-in-myosin-heavy-and-light-chain-formation-in-the-r6-2-mouse-model-of-huntington-s-disease
#11
Tanja Hering, Peter Braubach, G Bernhard Landwehrmeyer, Katrin S Lindenberg, Werner Melzer
Huntington´s disease (HD) is a hereditary neurodegenerative disease resulting from an expanded polyglutamine sequence (poly-Q) in the protein huntingtin (HTT). Various studies report atrophy and metabolic pathology of skeletal muscle in HD and suggest as part of the process a fast-to-slow fiber type transition that may be caused by the pathological changes in central motor control or/and by mutant HTT in the muscle tissue itself. To investigate muscle pathology in HD, we used R6/2 mice, a common animal model for a rapidly progressing variant of the disease expressing exon 1 of the mutant human gene...
2016: PloS One
https://www.readbyqxmd.com/read/27819014/isolation-culture-and-staining-of-single-myofibers
#12
Yann Simon Gallot, Sajedah M Hindi, Aman K Mann, Ashok Kumar
Adult skeletal muscle regeneration is orchestrated by a specialized population of adult stem cells called satellite cells, which are localized between the basal lamina and the plasma membrane of myofibers. The process of satellite cell-activation, proliferation, and subsequent differentiation that occurs during muscle regeneration can be recapitulated ex vivo by isolation of single myofibers from skeletal muscles and culturing them under suspension conditions. Here, we describe an improved protocol to evaluate ex vivo satellite cells activation through isolation of single myofibers from extensor digitorum longus (EDL) muscle of mice and culturing and staining of myofiber-associated satellite cells with the markers of self-renewal, proliferation, and differentiation...
October 5, 2016: Bio-protocol
https://www.readbyqxmd.com/read/27816210/interrater-reliability-in-the-clinical-evaluation-of-myofascial-trigger-points-in-three-ankle-muscles
#13
David Rodríguez Sanz, César Calvo Lobo, Daniel López López, Carlos Romero Morales, Carlos Sosa Marín, Irene Sanz Corbalán
OBJECTIVE: The purpose of this study was to evaluate interrater reliability in the diagnosis of myofascial trigger points (MTrPs) in the tibialis anterior, peroneus brevis, and extensor digitorum longus muscles. METHODS: A reliability research study was performed. Three physical therapists with clinical experience in myofascial pain functioned as raters and randomly and bilaterally evaluated the ankles of 40 subjects in the Madrid public health care system. The absence or presence of MTrPs, nodules in taut bands, patterns of referred pain, local twitch response (LTR), and jump-sign were evaluated...
November 2, 2016: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/27797909/enhanced-muscle-insulin-sensitivity-after-contraction-exercise-is-mediated-by-ampk
#14
Rasmus Kjøbsted, Nanna Munk-Hansen, Jesper B Birk, Marc Foretz, Benoit Viollet, Marie Björnholm, Juleen R Zierath, Jonas T Treebak, Jørgen F P Wojtaszewski
Earlier studies have demonstrated that muscle insulin sensitivity to stimulate glucose uptake is enhanced several hours after an acute bout of exercise. Using 5-aminoimidazole-4-carboxamide-ribonucleotide (AICAR), we recently demonstrated that prior activation of AMPK is sufficient to increase insulin sensitivity in mouse skeletal muscle. Here we aimed to determine whether activation of AMPK is also a prerequisite for the ability of muscle contraction to increase insulin sensitivity. We found that prior in situ contraction of m...
October 26, 2016: Diabetes
https://www.readbyqxmd.com/read/27796190/postoperative-physical-therapy-management-of-tendon-transfer-for-digital-wrist-extension-due-to-multifocal-motor-neuropathy
#15
Steve Volpe
Study Design Case report. Background Multifocal motor neuropathy is a progressive motor nerve disorder characterized by muscle weakness in the extremities. Muscle imbalance and weakness can become so severe that the involved extremity can be rendered nonfunctional. The purpose of this case report is to describe the physical therapy postoperative management of a patient who underwent a multiple tendon transfer to correct the loss of digital/wrist extension of the right upper extremity. Case Description A 38-year-old woman with a medical diagnosis of multifocal motor neuropathy, which caused muscle imbalance and weakness in the right hand, underwent a multiple tendon transfer to correct the loss of digit and wrist extension...
December 2016: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/27793139/a-short-term-statin-treatment-changes-the-contractile-properties-of-fast-twitch-skeletal-muscles
#16
Antoine Boulanger Piette, Sébastien S Dufresne, Jérôme Frenette
BACKGROUND: Cumulative evidence indicates that statins induce myotoxicity. However, the lack of understanding of how statins affect skeletal muscles at the structural, functional, and physiological levels hampers proper healthcare management. The purpose of the present study was to investigate the early after-effects of lovastatin on the slow-twitch soleus (Sol) and fast-twitch extensor digitorum longus (EDL) muscles. METHODS: Adult C57BL/6 mice were orally administrated with placebo or lovastatin [50 mg/kg/d] for 28 days...
October 28, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27765842/adrenodemedullation-activates-the-ca2-dependent-proteolysis-in-soleus-muscles-from-rats-exposed-to-cold
#17
Leandro H Manfredi, D Lustrino, Juliano Machado, Wilian Assis Silveira, Neusa Maria Zanon, Luiz C Navegantes, Isis do Carmo Kettelhut
Previous studies have shown that catecholamines in vivo and in vitro inhibit the activity of Ca(2+)-dependent proteolysis in skeletal muscles under basal conditions. In the present study we sought to investigate the role of catecholamines in regulating the Ca(2+)-dependent proteolysis in soleus and extensor digitorum longus (EDL) muscles from rats acutely exposed to cold. Overall proteolysis, the activity of proteolytic systems as well as protein levels and gene expression of different components of calpain system were investigated in rats submitted to adrenodemedullation (ADMX) and exposed to cold for 24 h...
October 20, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27741145/the-clinical-effect-of-tendon-repair-for-tendon-spontaneous-rupture-after-corticosteroid-injection-in-hands-a-retrospective-observational-study
#18
Hui Lu, Hu Yang, Hui Shen, Ganmin Ye, Xiang-Jin Lin
Corticosteroid injections for hand tendinitis can lead to a rare significant complication of tendon spontaneous rupture. However, only sporadic cases were reported in the literature before. This study was designed to gauge the clinical effect of tendon repair in patients of tendon spontaneous rupture after corticosteroid injection and analyze our experience.This was a retrospective observational study of 13 patients (8 women and 5 men) operated between July 2011 and December 2015 for tendon spontaneous rupture after corticosteroid injection...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27736981/impact-of-tieg1-deletion-on-the-passive-mechanical-properties-of-fast-and-slow-twitch-skeletal-muscles-in-female-mice
#19
Malek Kammoun, Philippe Pouletaut, Francis Canon, Malayannan Subramaniam, John R Hawse, Muriel Vayssade, Sabine F Bensamoun
As transforming growth factor (TGF)-β inducible early gene-1 is highly expressed in skeletal muscle, the effect of TIEG1 gene deletion on the passive mechanical properties of slow and fast twitch muscle fibers was analyzed. Twenty five muscle fibers were harvested from soleus (Sol) and extensor digitorum longus (EDL) muscles from TIEG1-/- (N = 5) and control (N = 5) mice. Mechanical tests were performed on fibers and the dynamic and static stresses were measured. A viscoelastic Hill model of 3rd order was used to fit the experimental relaxation test data...
2016: PloS One
https://www.readbyqxmd.com/read/27714474/predicting-muscle-fatigue-a-response-surface-approximation-based-on-proper-generalized-decomposition-technique
#20
M Sierra, J Grasa, M J Muñoz, F J Miana-Mena, D González
A novel technique is proposed to predict force reduction in skeletal muscle due to fatigue under the influence of electrical stimulus parameters and muscle physiological characteristics. Twelve New Zealand white rabbits were divided in four groups ([Formula: see text]) to obtain the active force evolution of in vitro Extensor Digitorum Longus muscles for an hour of repeated contractions under different electrical stimulation patterns. Left and right muscles were tested, and a total of 24 samples were used to construct a response surface based in the proper generalized decomposition...
October 6, 2016: Biomechanics and Modeling in Mechanobiology
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