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https://www.readbyqxmd.com/read/28343854/effect-of-maryland-s-2011-alcohol-sales-tax-increase-on-alcohol-positive-driving
#1
Marie-Claude Lavoie, Patricia Langenberg, Andres Villaveces, Patricia C Dischinger, Linda Simoni-Wastila, Kathleen Hoke, Gordon S Smith
INTRODUCTION: The 2011 Maryland alcohol sales tax increase from 6% to 9% provided an opportunity to evaluate the impact on rates of alcohol-positive drivers involved in injury crashes. METHODS: Maryland police crash reports from 2001 to 2013 were analyzed using an interrupted time series design and a multivariable analysis employing generalized estimating equations models with a negative binomial distribution. Data were analyzed in 2014-2015. RESULTS: There was a significant gradual annual reduction of 6% in the population-based rate of all alcohol-positive drivers (p<0...
March 8, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28336545/changes-in-intestinal-microbiota-composition-and-metabolism-coincide-with-increased-intestinal-permeability-in-young-adults-under-prolonged-physiologic-stress
#2
J Philip Karl, Lee M Margolis, Elisabeth H Madslien, Nancy E Murphy, John W Castellani, Yngvar Gundersen, Allison V Hoke, Michael W Levangie, Raina Kumar, Nabarun Chakraborty, Aarti Gautam, Rasha Hammamieh, Svein Martini, Scott J Montain, Stefan M Pasiakos
The magnitude, temporal dynamics, and physiologic effects of intestinal microbiome responses to physiologic stress are poorly characterized. This study used a systems biology approach and multiple-stressor military training environment to determine the effects of physiologic stress on intestinal microbiota composition and metabolic activity, and intestinal permeability (IP). 73 Soldiers were provided three rations/d with or without protein- or carbohydrate-based supplements during a four day cross-country ski march (STRESS)...
March 23, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28274575/relation-of-myocardial-contrast-enhanced-t1-mapping-by-cardiac-magnetic-resonance-to-left-ventricular-reverse-remodeling-after-cardiac-resynchronization-therapy-in-patients-with-nonischemic-cardiomyopathy
#3
Ulas Höke, Mand J H Khidir, Rob J van der Geest, Martin J Schalij, Jeroen J Bax, Victoria Delgado, Nina Ajmone Marsan
Myocardial scar is known to be associated with limited left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT). However, the impact of diffuse myocardial interstitial fibrosis, as assessed with myocardial T1 mapping cardiac magnetic resonance (CMR), has not been studied in patients with CRT. Therefore, we aimed at evaluating the association between diffuse myocardial interstitial fibrosis, in nonischemic cardiomyopathy patients, and LV reverse remodeling after CRT. A total of 40 patients (61 ± 11 years) with nonischemic cardiomyopathy who underwent CMR before CRT implantation were included...
February 9, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28108550/cardiac-resynchronization-therapy-in-adults-with-congenital-heart-disease
#4
Zeliha Koyak, Joris R de Groot, Ahmed Krimly, Tara M Mackay, Berto J Bouma, Candice K Silversides, Erwin N Oechslin, Ulas Hoke, Lieselot van Erven, Werner Budts, Isabelle C Van Gelder, Barbara J M Mulder, Louise Harris
AIMS: In adults with congenital heart disease (CHD) heart failure is one of the leading causes of morbidity and mortality but experience with and reported outcome of cardiac resynchronization therapy (CRT) is limited. We investigated the efficacy of CRT in adults with CHD. METHODS AND RESULTS: This was a retrospective study including 48 adults with CHD who received CRT since 2003 in four tertiary referral centres. Responders were defined as patients who showed improvement in NYHA functional class and/or systemic ventricular ejection fraction by at least one category...
January 20, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28106647/estimation-of-uterine-size-how-accurate-are-we
#5
Tanya P Hoke, Babak Vakili
OBJECTIVE: To evaluate the accuracy of gynecologic surgeons at estimating uterine dimensions and weight. METHODS: Six model uteri of various sizes were created to simulate the size and consistency of a uterus and displayed at 3 stations. The visual station (VS) comprised 2 specimens placed on an unmarked table. The laparoscopic station (LS) consisted of 2 model uteri, each placed in a separate simulated abdomen with a 0 degree laparoscope and 2 operative trocars with standard instruments...
January 18, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28103900/gde2-is-essential-for-neuronal-survival-in-the-postnatal-mammalian-spinal-cord
#6
Clinton Cave, Sungjin Park, Marianeli Rodriguez, Mai Nakamura, Ahmet Hoke, Mikhail Pletnikov, Shanthini Sockanathan
BACKGROUND: Glycerophosphodiester phosphodiesterase 2 (GDE2) is a six-transmembrane protein that cleaves glycosylphosphatidylinositol (GPI) anchors to regulate GPI-anchored protein activity at the cell surface. In the developing spinal cord, GDE2 utilizes its enzymatic function to regulate the production of specific classes of motor neurons and interneurons; however, GDE2's roles beyond embryonic neurogenesis have yet to be defined. METHOD: Using a panel of histological, immunohistochemical, electrophysiological, behavioral, and biochemistry techniques, we characterized the postnatal Gde2 (-/-) mouse for evidence of degenerative neuropathology...
January 19, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/27912838/evolutionary-perspectives-introduction-to-the-special-issue-on-axon-regeneration-across-species
#7
EDITORIAL
Zhigang He, Ahmet Höke
No abstract text is available yet for this article.
January 2017: Experimental Neurology
https://www.readbyqxmd.com/read/27871584/a-comparison-of-3-ventilation-strategies-in-children-younger-than-1-year-using-a-proseal-laryngeal-mask-airway-a-randomized-controlled-trial
#8
T Wesley Templeton, Lauren K Hoke, Leah B Templeton, Douglas G Ririe, Danielle M Rose, Yvon F Bryan
STUDY OBJECTIVE: To determine quantitative differences in several routinely measured ventilation parameters using a standardized anesthetic technique and 3 different ventilation modalities in patients younger than 1 year with a ProSeal laryngeal mask airway (PLMA). DESIGN: Randomized prospective study. SETTING: Tertiary care pediatric hospital. PATIENTS: Thirty-nine American Society Anesthesiologists classifications 1 to 2, pediatric patients younger than 1 year...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27803393/combined-effects-of-inflammatory-status-and-carotid-atherosclerosis-a-12-year-follow-up-study
#9
Florian J Mayer, Christoph J Binder, Oswald F Wagner, Martin Schillinger, Erich Minar, Wolfgang Mlekusch, Dimitris Tsiantoulas, Georg Goliasch, Matthias Hoke
BACKGROUND AND PURPOSE: Inflammatory responses play a key role in atherogenesis. The aim of this study was to assess the prognostic value of hsCRP (high-sensitivity C-reactive protein) and to evaluate whether degree of carotid stenosis and serum levels of hsCRP jointly predict long-term mortality in asymptomatic patients with carotid atherosclerosis. METHODS: One thousand sixty-five patients with neurological asymptomatic carotid atherosclerosis as evaluated by duplex sonography were prospectively followed for cause-specific mortality...
December 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27767076/direct-and-indirect-mechanisms-of-klk4-inhibition-revealed-by-structure-and-dynamics
#10
Blake T Riley, Olga Ilyichova, Mauricio G S Costa, Benjamin T Porebski, Simon J de Veer, Joakim E Swedberg, Itamar Kass, Jonathan M Harris, David E Hoke, Ashley M Buckle
The kallikrein-related peptidase (KLK) family of proteases is involved in many aspects of human health and disease. One member of this family, KLK4, has been implicated in cancer development and metastasis. Understanding mechanisms of inactivation are critical to developing selective KLK4 inhibitors. We have determined the X-ray crystal structures of KLK4 in complex with both sunflower trypsin inhibitor-1 (SFTI-1) and a rationally designed SFTI-1 derivative to atomic (~1 Å) resolution, as well as with bound nickel...
October 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27759100/the-astrocytic-transporter-slc7a10-asc-1-mediates-glycinergic-inhibition-of-spinal-cord-motor-neurons
#11
Jeffrey T Ehmsen, Yong Liu, Yue Wang, Nikhil Paladugu, Anna E Johnson, Jeffrey D Rothstein, Sascha du Lac, Mark P Mattson, Ahmet Höke
SLC7A10 (Asc-1) is a sodium-independent amino acid transporter known to facilitate transport of a number of amino acids including glycine, L-serine, L-alanine, and L-cysteine, as well as their D-enantiomers. It has been described as a neuronal transporter with a primary role related to modulation of excitatory glutamatergic neurotransmission. We find that SLC7A10 is substantially enriched in a subset of astrocytes of the caudal brain and spinal cord in a distribution corresponding with high densities of glycinergic inhibitory synapses...
October 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27721079/a-non-cleavable-hexahistidine-affinity-tag-at-the-carboxyl-terminus-of-the-hiv-1-pr55-gag-polyprotein-alters-nucleic-acid-binding-properties
#12
Maria C Bewley, Lisa Reinhart, Matthew S Stake, Shorena Nadaraia-Hoke, Leslie J Parent, John M Flanagan
HIV Gag (Pr55(Gag)), a multidomain polyprotein that orchestrates the assembly and release of the human immunodeficiency virus (HIV), is an active target of antiretroviral inhibitor development. However, highly pure, stable, recombinant Pr55(Gag) has been difficult to produce in quantities sufficient for biophysical studies due to its susceptibility to proteolysis by cellular proteases during purification. Stability has been improved by using a construct that omits the p6 domain (Δp6). In vivo, p6 is crucial to the budding process and interacts with protein complexes in the ESCRT (Endosomal Sorting Complexes Required for Transport) pathway, it has been difficult to study its role in the context of Gag using in vitro approaches...
February 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/27689748/age-related-changes-in-cerebellar-and-hypothalamic-function-accompany-non-microglial-immune-gene-expression-altered-synapse-organization-and-excitatory-amino-acid-neurotransmission-deficits
#13
Stephen J Bonasera, Jyothi Arikkath, Michael D Boska, Tammy R Chaudoin, Nicholas W DeKorver, Evan H Goulding, Traci A Hoke, Vahid Mojtahedzedah, Crystal D Reyelts, Balasrinivasa Sajja, A Katrin Schenk, Laurence H Tecott, Tiffany A Volden
We describe age-related molecular and neuronal changes that disrupt mobility or energy balance based on brain region and genetic background. Compared to young mice, aged C57BL/6 mice exhibit marked locomotor (but not energy balance) impairments. In contrast, aged BALB mice exhibit marked energy balance (but not locomotor) impairments. Age-related changes in cerebellar or hypothalamic gene expression accompany these phenotypes. Aging evokes upregulation of immune pattern recognition receptors and cell adhesion molecules...
September 20, 2016: Aging
https://www.readbyqxmd.com/read/27687391/comparing-3-ventilation-modalities-by-measuring-several-respiratory-parameters-using-the-proseal-laryngeal-mask-airway-in-children
#14
T Wesley Templeton, Lauren K Hoke, Jill Yaung, Carol A Aschenbrenner, Danielle M Rose, Leah B Templeton, Yvon F Bryan
STUDY OBJECTIVE: To determine quantitative differences in several routinely measured ventilation parameters using a standardized anesthetic technique and 3 different ventilation modalities in pediatric patients with a ProSeal laryngeal mask airway (PLMA). DESIGN: Randomized prospective study. SETTING: Pediatric hospital of a tertiary care academic medical center. PATIENTS: Thirty-three, American Society of Anesthesiologists classification 1-2, pediatric patients (12 months to 5 years)...
November 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27679297/surgical-outcomes-of-paravaginal-repair-following-robotic-sacrocolpopexy
#15
T P Hoke, B Vakili, H Goldstein, E K Saks
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27677839/the-complex-evolutionary-history-of-the-tympanic-middle-ear-in-frogs-and-toads-anura
#16
Martín O Pereyra, Molly C Womack, J Sebastián Barrionuevo, Boris L Blotto, Diego Baldo, Mariane Targino, Jhon Jairo Ospina-Sarria, Juan M Guayasamin, Luis A Coloma, Kim L Hoke, Taran Grant, Julián Faivovich
Most anurans possess a tympanic middle ear (TME) that transmits sound waves to the inner ear; however, numerous species lack some or all TME components. To understand the evolution of these structures, we undertook a comprehensive assessment of their occurrence across anurans and performed ancestral character state reconstructions. Our analysis indicates that the TME was completely lost at least 38 independent times in Anura. The inferred evolutionary history of the TME is exceptionally complex in true toads (Bufonidae), where it was lost in the most recent common ancestor, preceding a radiation of >150 earless species...
September 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27667094/smoothing-a-rugged-protein-folding-landscape-by-sequence-based-redesign
#17
Benjamin T Porebski, Shani Keleher, Jeffrey J Hollins, Adrian A Nickson, Emilia M Marijanovic, Natalie A Borg, Mauricio G S Costa, Mary A Pearce, Weiwen Dai, Liguang Zhu, James A Irving, David E Hoke, Itamar Kass, James C Whisstock, Stephen P Bottomley, Geoffrey I Webb, Sheena McGowan, Ashley M Buckle
The rugged folding landscapes of functional proteins puts them at risk of misfolding and aggregation. Serine protease inhibitors, or serpins, are paradigms for this delicate balance between function and misfolding. Serpins exist in a metastable state that undergoes a major conformational change in order to inhibit proteases. However, conformational labiality of the native serpin fold renders them susceptible to misfolding, which underlies misfolding diseases such as α1-antitrypsin deficiency. To investigate how serpins balance function and folding, we used consensus design to create conserpin, a synthetic serpin that folds reversibly, is functional, thermostable, and polymerization resistant...
September 26, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27626947/towards-translation-of-discrete-frequency-infrared-spectroscopic-imaging-for-digital-histopathology-of-clinical-biopsy-samples
#18
Saumya Tiwari, Jai Raman, Vijaya Reddy, Andrew Ghetler, Richard P Tella, Yang Han, Christopher R Moon, Charles D Hoke, Rohit Bhargava
Fourier transform infrared (FT-IR) spectroscopic imaging has been widely tested as a tool for stainless digital histology of biomedical specimens, including for the identification of infiltration and fibrosis in endomyocardial biopsy samples to assess transplant rejection. A major barrier in clinical translation has been the slow speed of imaging. To address this need, we tested and report here the viability of using high speed discrete frequency infrared (DFIR) imaging to obtain stain-free biochemical imaging in cardiovascular samples collected from patients...
October 18, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27624549/maintenance-therapy-with-decitabine-in-younger-adults-with-acute-myeloid-leukemia-in-first-remission-a-phase-2-cancer-and-leukemia-group-b-study-calgb-10503
#19
W Blum, B L Sanford, R Klisovic, D J DeAngelo, G Uy, B L Powell, W Stock, M R Baer, J E Kolitz, E S Wang, E Hoke, K Mrózek, J Kohlschmidt, C D Bloomfield, S Geyer, G Marcucci, R M Stone, R A Larson
In this prospective phase 2 clinical trial conducted by Cancer and Leukemia Group B (CALGB, now the Alliance), we studied decitabine as maintenance therapy for younger adults with acute myeloid leukemia (AML) who remained in first complete remission (CR1) following intensive induction and consolidation. Given that decitabine is clinically active in AML and with hypomethylating activity distinct from cytotoxic chemotherapy, we hypothesized that 1 year of maintenance therapy would improve disease-free survival (DFS) for AML patients <60 years, who did not receive allogeneic stem cell transplantation in CR1...
January 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27586169/long-term-echocardiographic-outcome-in-super-responders-to-cardiac-resynchronization-therapy-and-the-association-with-mortality-and-defibrillator-therapy
#20
Aafke C van der Heijden, Ulas Höke, Joep Thijssen, C Jan Willem Borleffs, Ron Wolterbeek, Martin J Schalij, Lieselot van Erven
Super-response to cardiac resynchronization therapy (CRT) is associated with significant left ventricular (LV) reverse remodeling and improved clinical outcome. The study aimed to: (1) evaluate whether LV reverse remodeling remains sustained during long-term follow-up in super-responders and (2) analyze the association between the course of LV reverse remodeling and ventricular arrhythmias. Of all, primary prevention super-responders to CRT were selected. Super-response was defined as LV end-systolic volume reduction of ≥30% 6 months after device implantation...
October 15, 2016: American Journal of Cardiology
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