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Julius Birnbaum, Ahmet Hoke, Aliya Lalji, Peter Calabresi, Pavan Bhargava, Livia Casciola-Rosen
OBJECTIVE: Autoantibodies are clinically useful for phenotyping patients across the spectrum of autoimmune rheumatic diseases. Using serum from a patient with Sjögren's Syndrome (SS), we detected a new specificity by immunoblotting. The purpose of this study was to identify this autoantibody and to evaluate its disease specificity. METHODS: A prominent 40 kDa band was detected when immunoblots were performed using a SS patient serum and lysate from rat dorsal root ganglia (DRG)...
May 11, 2018: Arthritis & Rheumatology
Alison Dolce, Polan Santos, Weiran Chen, Ahmet Hoke, Adam L Hartman
BACKGROUND: Despite the introduction of new medicines to treat epilepsy over the last 50 years, the number of patients with poorly-controlled seizures remains unchanged. Metabolism-based therapies are an underutilized treatment option for this population. We hypothesized that two different means of systemic ketosis, the ketogenic diet and intermittent fasting, would differ in their acute seizure test profiles and mitochondrial respiration. METHODS: Male NIH Swiss mice (aged 3-4 weeks) were fed for 12-13 days using one of four diet regimens: ketogenic diet (KD), control diet matched to KD for protein content and micronutrients (CD), or CD with intermittent fasting (24 h feed/24 h fast) (CD-IF), tested post-feed or post-fast...
April 27, 2018: Epilepsy Research
Molly C Womack, Jakob Christensen-Dalsgaard, Luis A Coloma, Kim L Hoke
Harlequin frogs, genus Atelopus , communicate at high frequencies despite most species lacking a complete tympanic middle ear that facilitates high frequency hearing in most anurans and other tetrapods. Here we test whether Atelopus are better at sensing high frequency acoustic sound compared to other eared and earless species in the Bufonidae family, determine whether middle ear variation within Atelopus affects hearing sensitivity, and test potential hearing mechanisms in Atelopus We determine that at high frequencies (2000-4000 Hz) Atelopus are 10-34 dB more sensitive than other earless bufonids but are relatively insensitive to mid-range frequencies (900-1500 Hz) compared to eared bufonids...
April 19, 2018: Journal of Experimental Biology
Enrico Cristante, Sidath E Liyanage, Robert D Sampson, Aikaterini Kalargyrou, Giulia De Rossi, Matteo Rizzi, Justin Hoke, Joana Ribeiro, Ryea N Maswood, Yanai Duran, Takaaki Matsuki, Nozie Aghaizu, Ulrich F Luhmann, Alexander J Smith, Robin R Ali, James W B Bainbridge
In the adult central nervous system, endothelial and neuronal cells engage in tight cross-talk as key components of the so-called neurovascular unit. Impairment of their critical relationship adversely affects tissue homeostasis, as observed in neurodegenerative conditions including Alzheimer's and Parkinson's disease. In development, the influence of neuroprogenitor cells on angiogenesis is poorly understood. Here, we show that these cells interact intimately with the growing retinal vascular network, and we identify a novel regulatory mechanism of vasculature development mediated by hypoxia-inducible factor 2a ( Hif2a )...
April 3, 2018: Development
Sophia-Martha Kleine Holthaus, Joana Ribeiro, Laura Abelleira-Hervas, Rachael A Pearson, Yanai Duran, Anastasios Georgiadis, Robert D Sampson, Matteo Rizzi, Justin Hoke, Ryea Maswood, Selina Azam, Ulrich F O Luhmann, Alexander J Smith, Sara E Mole, Robin R Ali
The neuronal ceroid lipofuscinoses (NCLs) are inherited lysosomal storage disorders characterized by general neurodegeneration and premature death. Sight loss is also a major symptom in NCLs, severely affecting the quality of life of patients, but it is not targeted effectively by brain-directed therapies. Here we set out to explore the therapeutic potential of an ocular gene therapy to treat sight loss in NCL due to a deficiency in the transmembrane protein CLN6. We found that, although Cln6nclf mice presented mainly with photoreceptor degeneration, supplementation of CLN6 in photoreceptors was not beneficial...
March 2, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
Cameron K Ghalambor, Kim L Hoke, Emily W Ruell, Eva K Fischer, David N Reznick, Kimberly A Hughes
This corrects the article DOI: 10.1038/nature15256.
March 28, 2018: Nature
Cameron K Ghalambor, Kim L Hoke, Emily W Ruell, Eva K Fischer, David N Reznick, Kimberly A Hughes
No abstract text is available yet for this article.
March 28, 2018: Nature
Jeanine F Amacher, Fangfang Zhong, George P Lisi, Michael Q Zhu, Stephanie L Alden, Kevin R Hoke, Dean R Madden, Ekaterina V Pletneva
No abstract text is available yet for this article.
March 28, 2018: Journal of the American Chemical Society
Morgan K Hoke, Kimberly A McCabe, Aaron A Miller, Thomas W McDade
OBJECTIVE: To validate a method for measuring endotoxin-core antibodies (EndoCAb) from dried blood spots (DBS)-drops of capillary whole blood collected and dried on filter paper-as an indicator of environmental enteropathy (EE) in infancy and early childhood. METHODS: A commercially available enzyme immunoassay kit was adapted for use with DBS, with optimized steps for sample elution. Technical validation included analysis of linearity/recovery, precision and reliability, lower limit of detection, and correspondence between matched plasma and DBS samples...
March 13, 2018: American Journal of Human Biology: the Official Journal of the Human Biology Council
Tae Chung, Yanli Tian, Jeremy Walston, Ahmet Hoke
OBJECTIVE: Age-associated skeletal muscle weakness is a major contributing factor to an increased late life mortality and morbidity, but its neurobiology is poorly understood. Previously, we provided histological evidence of dying-back axonal degeneration of motor neurons and denervation of neuromuscular junctions (NMJ) in age-associated muscle weakness. Given this, we aim to evaluate the relation between impaired neuromuscular transmission and various aspects of age-associated muscle weakness...
March 1, 2018: American Journal of Physical Medicine & Rehabilitation
Ricardo H Roda, Brett A McCray, Christopher J Klein, Ahmet Hoke
No abstract text is available yet for this article.
February 2018: Neurology. Genetics
Seoung-Ryoung Choi, Bradley E Britigan, Barbara Switzer, Traci Hoke, David Moran, Prabagaran Narayanasamy
The nontuberculous mycobacterial (NTM) pathogens, M. avium complex (MAC) and M. abscessus, can result in severe pulmonary infections. Current antibiotics confront significant challenges for treatment of these NTM infections due to emerging multidrug-resistance. Thus, development of new antibiotics targeted against these agents is needed. We examined the inhibitory activities of Ga(NO3 )3 , GaCl3 , gallium meso-tetraphenylporphyrine (GaTP), and gallium nanoparticles (GaNP) against intra- and extracellular M...
March 5, 2018: Molecular Pharmaceutics
Nabarun Chakraborty, Amrita Cheema, Aarti Gautam, Duncan Donohue, Allison Hoke, Carolynn Conley, Marti Jett, Rasha Hammamieh
Spaceflight presents a spectrum of stresses very different from those associated with terrestrial conditions. Our previous study (BMC Genom. 15 : 659, 2014) integrated the expressions of mRNAs, microRNAs, and proteins and results indicated that microgravity induces an immunosuppressive state that can facilitate opportunistic pathogenic attack. However, the existing data are not sufficient for elucidating the molecular drivers of the given immunosuppressed state. To meet this knowledge gap, we focused on the metabolite profile of spaceflown human cells...
2018: NPJ Microgravity
Nicole Hoke
No abstract text is available yet for this article.
February 2018: AORN Journal
Molly C Womack, Tyler S Fiero, Kim L Hoke
The repeated, independent evolution of traits (convergent evolution) is often attributed to shared environmental selection pressures. However, developmental dependencies among traits can limit the phenotypic variation available to selection and bias evolutionary outcomes. Here, we determine how changes in developmentally correlated traits may impact convergent loss of the tympanic middle ear, a highly labile trait within toads that currently lack adaptive explanation. The middle ear's lability could reflect evolutionary trade-offs with other skull features under selection, or the middle ear may evolve independently of the rest of the skull, allowing it to be modified by active or passive processes without pleiotropic trade-offs with other skull features...
March 2018: Evolution; International Journal of Organic Evolution
Ulas Höke, Jeroen J Bax, Victoria Delgado, Nina Ajmone Marsan
BACKGROUND: Systolic dyssynchrony index (SDI) using three-dimensional echocardiography (3DE) was shown to be a reliable measure of left ventricular (LV) dyssynchrony. However, the prognostic value of SDI on long-term outcomes after cardiac resynchronization therapy (CRT) remains unknown. METHODS AND RESULTS: A total of 414 patients (mean age 67 ± 10 years, 60% ischemic etiology) with 3DE evaluation before CRT implantation were included. SDI was evaluated as continuous value and in quartiles...
January 29, 2018: Journal of Cardiovascular Electrophysiology
Tanya P Hoke, Howard Goldstein, Emily K Saks, Babak Vakili
STUDY OBJECTIVE: To evaluate surgical outcomes of robotic sacrocolpopexy with and without paravaginal repair for pelvic organ prolapse (POP). DESIGN: A retrospective cohort study with a 3-month postoperative follow-up (Canadian Task Force classification II-3). SETTING: An academic-affiliated community hospital with a practice comprised of 3 surgeons board certified in female pelvic medicine and reconstructive surgery. PATIENTS: Patients undergoing robotic sacrocolpopexy for POP from April 2013 through November 2014...
January 31, 2018: Journal of Minimally Invasive Gynecology
Nina A Bickell, Jenny J Lin, Sarah R Abramson, Gerald P Hoke, William Oh, Simon J Hall, Richard Stock, Kezhen Fei, Ann Scheck McAlearney
PURPOSE: Black men are more likely to die as a result of prostate cancer than white men, despite effective treatments that improve survival for clinically significant prostate cancer. We undertook this study to identify gaps in prostate cancer care quality, racial disparities in care, and underlying reasons for poorer quality care. METHODS: We identified all black men and random age-matched white men with Gleason scores ≥ 7 diagnosed between 2006 and 2013 at two urban hospitals to determine rates of treatment underuse...
January 2018: Journal of Oncology Practice
Yutaro Kawazu, Hiroshi Hoke, Yasunori Yamada, Tatsuya Umecky, Kazuhiko Ozutsumi, Toshiyuki Takamuku
The thermodynamics of complex formation of Ni2+ with molecular liquids (ML), dimethyl sulfoxide (DMSO), methanol (MeOH), and acetonitrile (AN) in the ionic liquid (IL) of 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)amide ([C2 mim][TFSA]) has been elucidated using ultraviolet (UV)-visible spectroscopy. X-ray structural analyses for single crystals grown from Ni2+ -[C2 mim][TFSA]-DMSO and -AN solutions at high ML contents have shown that six DMSO oxygen or AN nitrogen atoms coordinate with Ni2+ to form octahedral structures of [Ni(dmso)6 ](TFSA)2 and [Ni(an)6 ](TFSA)2 , respectively...
November 29, 2017: Physical Chemistry Chemical Physics: PCCP
Phyllis Hoke, Mark Tiede, Julie Grender, Malgorzata Klukowska, Jill Peters, Gregory Carr
PURPOSE: To study the effects of denture adhesive upon denture micromovements in three dimensions during the chewing of hard, sticky, and tough food items observed using a novel method involving an electromagnetic articulograph (EMA) speech research system. MATERIALS AND METHODS: Ten volunteers (mean age 60.9 ± 10.4 years) with fair- or poor-fitting complete maxillary dentures were enrolled. Chewing experiments were conducted using two treatments (adhesive or no-adhesive control) and three foods: carrots (hard), raisins (sticky), and processed meat stick (tough)...
November 14, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
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