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https://www.readbyqxmd.com/read/29148560/complex-formation-of-nickel-ii-with-dimethyl-sulfoxide-methanol-and-acetonitrile-in-a-tfsa-based-ionic-liquid-of-c2mim-tfsa
#1
Yutaro Kawazu, Hiroshi Hoke, Yasunori Yamada, Tatsuya Umecky, Kazuhiko Ozutsumi, Toshiyuki Takamuku
The thermodynamics of complex formation of Ni(2+) with molecular liquids (ML), dimethyl sulfoxide (DMSO), methanol (MeOH), and acetonitrile (AN) in the ionic liquid (IL) of 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)amide ([C2mim][TFSA]) has been elucidated using ultraviolet (UV)-visible spectroscopy. X-ray structural analyses for single crystals grown from Ni(2+)-[C2mim][TFSA]-DMSO and -AN solutions at high ML contents have shown that six DMSO oxygen or AN nitrogen atoms coordinate with Ni(2+) to form octahedral structures of [Ni(dmso)6](TFSA)2 and [Ni(an)6](TFSA)2, respectively...
November 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29136307/using-electromagnetic-articulography-to-measure-denture-micromovement-during-chewing-with-and-without-denture-adhesive
#2
Phyllis Hoke, Mark Tiede, Julie Grender, Malgorzata Klukowska, Jill Peters, Gregory Carr
PURPOSE: To study the effects of denture adhesive upon denture micromovements in three dimensions during the chewing of hard, sticky, and tough food items observed using a novel method involving an electromagnetic articulograph (EMA) speech research system. MATERIALS AND METHODS: Ten volunteers (mean age 60.9 ± 10.4 years) with fair- or poor-fitting complete maxillary dentures were enrolled. Chewing experiments were conducted using two treatments (adhesive or no-adhesive control) and three foods: carrots (hard), raisins (sticky), and processed meat stick (tough)...
November 14, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29076733/recovery-of-lithium-from-geothermal-brine-with-lithium-aluminum-layered-double-hydroxide-chloride-sorbents
#3
Mariappan Parans Paranthaman, Ling Li, Jiaqi Luo, Thomas Hoke, Huseyin Ucar, Bruce A Moyer, Stephen Harrison
We report a three-stage bench-scale column extraction process to selectively extract lithium chloride from geothermal brine. The goal of this research is to develop materials and processing technologies to improve the economics of lithium extraction and production from naturally occurring geothermal and other brines for energy storage applications. A novel sorbent, lithium aluminum layered double hydroxide chloride (LDH), is synthesized and characterized with X-ray powder diffraction, scanning electron microscopy, inductively coupled plasma optical emission spectrometry (ICP-OES), and thermogravimetric analysis...
October 27, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29070896/a-formulation-of-pancreatic-pro-enzymes-provides-potent-anti-tumour-efficacy-a-pilot-study-focused-on-pancreatic-and-ovarian-cancer
#4
Macarena Perán, Elena López-Ruiz, María Ángel García, Shorena Nadaraia-Hoke, Ralf Brandt, Juan A Marchal, Julian Kenyon
Proteolytic enzymes have shown efficacy in cancer therapy. We present a combination of the two pro-enzymes Trypsinogen and Chymotrypsinogen A with potent in vitro and in vivo anti-tumour efficacy. A synergetic anti-tumour effect for Trypsinogen and Chymotrypsinogen A was determined at a ratio 1:6 (named PRP) using 24 human cancer cell lines. The antiangiogenic effect of PRP was analysed by matrigel-based tube formation and by fibrous capsule formation assays. Furthermore, cell invasion and wound healing assays together with qRT-PCR determination of epithelial-to-mesenchymal transition (EMT) markers were performed on human cancer cells treated with PRP...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29048534/neural-circuitry-for-target-selection-and-action-selection-in-animal-behavior
#5
Kim L Hoke, Eileen A Hebets, Daizaburo Shizuka
Animal behaviorists have long strived for a comprehensive understanding of the proximate and ultimate causes of complex behavior, and we propose that recent advances in neurobiology can help reshape or clarify this behavior-oriented understanding. We begin with an overview of current views of neural circuit mechanisms that mediate target selection and action selection. In target selection, different stimuli compete for priority in sensory-motor processing. Action selection is the process by which multiple possible motor actions compete for priority in a manner which balances the needs of the animal with opportunities or threats in the environment...
October 1, 2017: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/29036317/quality-of-local-school-wellness-policies-for-physical-activity-and-resultant-implementation-in-pennsylvania-schools
#6
E Francis, E Hivner, A Hoke, T Ricci, A Watach, J Kraschnewski
Background: In 2006, United States public schools participating in federal school meal programs were required to adopt school wellness policies. The effect of these policies on school nutrition environments is well documented; however, evaluation of physical activity policies has received less investigation. We aimed to evaluate how district wellness policies aligned to practice for physical activity implementation in 40 schools with high obesity rates (>24%). Methods: Wellness policies were evaluated using the validated Wellness School Assessment Tool (WellSAT)...
September 28, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/29031415/usefulness-of-the-crt-score-for-shared-decision-making-in-cardiac-resynchronization-therapy-in-patients-with-a-left-ventricular-ejection-fraction-of-%C3%A2-35
#7
Ulas Höke, Bart Mertens, Mand J H Khidir, Martin J Schalij, Jeroen J Bax, Victoria Delgado, Nina Ajmone Marsan
Individualized estimation of prognosis after cardiac resynchronization therapy (CRT) remains challenging. Our aim was to develop a multiparametric prognostic risk score (CRT-SCORE) that could be used for patient-specific clinical shared decision making about CRT implantation. The CRT-SCORE was derived from an ongoing CRT registry, including 1,053 consecutive patients (age 67 ± 10 years, 76% male). Using preimplantation variables, 100 multiple imputed datasets were generated for model calibration. Based on multivariate Cox regression models, cross-validated linear prognostic scores were calculated, as well as survival fractions at 1 and 5 years...
August 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29027366/collaborative-research-among-academia-business-and-government
#8
Peter M Chapman, Richard A Brain, Jason B Belden, Valery E Forbes, Christopher A Mebane, Robert A Hoke, Gary T Ankley, Keith R Solomon
No abstract text is available yet for this article.
October 12, 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/29019867/the-effects-of-various-weighted-implements-on-baseball-swing-kinematics-in-collegiate-baseball-players
#9
Charles C Williams, Jacob R Gdovin, Samuel J Wilson, Vanessa L Cazas-Moreno, John D Eason, Elizabeth L Hoke, Charles R Allen, Chip Wade, John C Garner
The purpose of this study was to investigate the effects of different warm-up (WU) devices on bat swing parameters including maximal resultant velocity (MRV), resultant velocity at ball contact (RVBC), time difference between MRV and RVBC, bat angle at MRV, bat angle at RVBC, and perceptual differences (PD) of each WU implement utilized by National Collegiate Athletic Association (NCAA) Division-I baseball players. Fifteen varsity baseball players completed one experimental session during fall training. Retro-reflective markers were placed on the bat and tee to measure basic bat kinematics during the swing...
June 3, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28978737/earless-toads-sense-low-frequencies-but-miss-the-high-notes
#10
Molly C Womack, Jakob Christensen-Dalsgaard, Luis A Coloma, Juan C Chaparro, Kim L Hoke
Sensory losses or reductions are frequently attributed to relaxed selection. However, anuran species have lost tympanic middle ears many times, despite anurans' use of acoustic communication and the benefit of middle ears for hearing airborne sound. Here we determine whether pre-existing alternative sensory pathways enable anurans lacking tympanic middle ears (termed earless anurans) to hear airborne sound as well as eared species or to better sense vibrations in the environment. We used auditory brainstem recordings to compare hearing and vibrational sensitivity among 10 species (six eared, four earless) within the Neotropical true toad family (Bufonidae)...
October 11, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28842425/photoacoustic-imaging-for-in-vivo-quantification-of-placental-oxygenation-in-mice
#11
Liliya M Yamaleyeva, Yao Sun, Tiffaney Bledsoe, Asia Hoke, Susan B Gurley, K Bridget Brosnihan
Accurate analysis of placental and fetal oxygenation is critical during pregnancy. Photoacoustic imaging (PAI) combines laser technology with ultrasound in real time. We tested the sensitivity and accuracy of PAI for analysis of placental and fetal O2 saturation (sO2) in mice. The placental labyrinth (L) had a higher sO2 than the junctional zone plus decidua region (JZ+D) in C57Bl/6 mice. Changing maternal O2 from 100 to 20% in C57Bl/6 mice lowered sO2 in these regions. C57Bl/6 mice were treated with the NO synthase inhibitor L-N(G)-nitroarginine methyl ester (L-NAME) from gestational day (GD) 11 to GD18 to induce hypertension...
August 21, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28712155/economic-activity-and-patterns-of-infant-growth-in-a-high-altitude-district-of-peru
#12
Morgan K Hoke
OBJECTIVES: Changing economic activities bring significant cultural, epidemiological, and nutritional transitions. Infancy represents a critical period when rapid growth and metabolic programming occur, making infants particularly vulnerable to long-lasting biological changes due to such transitions. This paper examines the relationship between residence in distinct economic production zones (urban, herding, and dairy) and early growth in a highland district of Peru. METHODS: The length, weight, body mass index, and triceps skinfold of 93 infants (55 boys and 38 girls, aged 2 to 24 months) from 3 economic zones were measured at two time points 6 months apart...
July 16, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28661304/expanding-access-to-care-scope-of-practice-laws
#13
Kathleen Hoke, Sarah Hexem
Allied health professionals play an integral role in providing safe, affordable care to communities in need. Laws that define the permissible scope of practice for these professionals may take full advantage of these providers and may unnecessarily restrict safe and effective care. Nurse practitioners in many states may provide care independent of a physician; research reveals that this care is safe, affordable and accessible. Yet hurdles exist that prevent communities from securing the full benefit of NPs in independent practice...
March 2017: Journal of Law, Medicine & Ethics: a Journal of the American Society of Law, Medicine & Ethics
https://www.readbyqxmd.com/read/28630072/pseudomonas-quinolone-signal-induces-oxidative-stress-and-inhibits-heme-oxygenase-1-expression-in-lung-epithelial-cells
#14
Maher Y Abdalla, Traci Hoke, Javier Seravalli, Barbara L Switzer, Melissa Bavitz, Jill D Fliege, Peter J Murphy, Bradley E Britigan
Pseudomonasaeruginosa causes lung infections in patients with cystic fibrosis (CF). The Pseudomonas quinolone signal (PQS) compound is a secreted P. aeruginosa virulence factor that contributes to the pathogenicity of P. aeruginosa We were able to detect PQS in sputum samples from CF patients infected with P. aeruginosa but not in samples from uninfected patients. We then tested the hypothesis that PQS induces oxidative stress in host cells by determining the ability of PQS to induce the production of reactive oxygen species (ROS) in lung epithelial cells (A549 and primary normal human bronchial epithelial [NHBE]) cells and macrophages (J774A...
September 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28534873/molecular-indicators-of-stress-induced-neuroinflammation-in-a-mouse-model-simulating-features-of-post-traumatic-stress-disorder
#15
S Muhie, A Gautam, N Chakraborty, A Hoke, J Meyerhoff, R Hammamieh, M Jett
A social-stress mouse model was used to simulate features of post-traumatic stress disorder (PTSD). The model involved exposure of an intruder (male C57BL/6) mouse to a resident aggressor (male SJL) mouse for 5 or 10 consecutive days. Transcriptome changes in brain regions (hippocampus, amygdala, medial prefrontal cortex and hemibrain), blood and spleen as well as epigenome changes in the hemibrain were assayed after 1- and 10-day intervals following the 5-day trauma or after 1- and 42-day intervals following the 10-day trauma...
May 23, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28534044/hsp-and-deafness-neurocristopathy-caused-by-a-novel-mosaic-sox10-mutation
#16
Sandra Donkervoort, Diana Bharucha-Goebel, Pomi Yun, Ying Hu, Payam Mohassel, Ahmet Hoke, Wadih M Zein, Daniel Ezzo, Andrea M Atherton, Ann C Modrcin, Majed Dasouki, A Reghan Foley, Carsten G Bönnemann
OBJECTIVE: To identify the underlying genetic cause in 2 sisters affected with progressive lower extremity spasticity, neuropathy, and early-onset deafness. METHODS: Whole-exome sequencing was performed, and segregation testing of variants was investigated using targeted Sanger sequencing. An inherited paternal mosaic mutation was further evaluated through quantitative analysis of the ratio of mutant vs wild-type allele in genomic DNA from various tissues, including blood, dermal fibroblasts, and saliva...
June 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28529212/exploring-the-case-for-eminent-domain-of-hepatitis-c-virus-treatment-patents
#17
T Joseph Mattingly Ii, Emily L Heil, Kathleen S Hoke
Hepatitis C virus (HCV) is a silent epidemic affecting millions of patients and represents the leading indication for liver transplantation in the United States and worldwide. New direct-acting antiviral agents offer the potential to cure patients infected with HCV but it comes at a staggering cost. Given the recent attention to these high-priced HCV therapies and the impact treating individuals with HCV is having on drug expenditures in the United States, there may be a need to revisit drug patent laws and the options the federal government has to ensure patient access to care...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28487425/a-variant-pfcrt-isoform-can-contribute-to-plasmodium-falciparum-resistance-to-the-first-line-partner-drug-piperaquine
#18
Satish K Dhingra, Devasha Redhi, Jill M Combrinck, Tomas Yeo, John Okombo, Philipp P Henrich, Annie N Cowell, Purva Gupta, Matthew L Stegman, Jonathan M Hoke, Roland A Cooper, Elizabeth Winzeler, Sachel Mok, Timothy J Egan, David A Fidock
Current efforts to reduce the global burden of malaria are threatened by the rapid spread throughout Asia of Plasmodium falciparum resistance to artemisinin-based combination therapies, which includes increasing rates of clinical failure with dihydroartemisinin plus piperaquine (PPQ) in Cambodia. Using zinc finger nuclease-based gene editing, we report that addition of the C101F mutation to the chloroquine (CQ) resistance-conferring PfCRT Dd2 isoform common to Asia can confer PPQ resistance to cultured parasites...
May 9, 2017: MBio
https://www.readbyqxmd.com/read/28485482/deletion-of-sarm1-gene-is-neuroprotective-in-two-models-of-peripheral-neuropathy
#19
Elliot Turkiew, Debbie Falconer, Nicole Reed, Ahmet Höke
Distal axon degeneration seen in many peripheral neuropathies is likely to share common molecular mechanisms with Wallerian degeneration. Although several studies in mouse models of peripheral neuropathy showed prevention of axon degeneration in the slow Wallerian degeneration (Wlds) mouse, the role of a recently identified player in Wallerian degeneration, Sarm1, has not been explored extensively. In this study, we show that mice lacking the Sarm1 gene are resistant to distal axonal degeneration in a model of chemotherapy induced peripheral neuropathy caused by paclitaxel and a model of high fat diet induced putative metabolic neuropathy...
September 2017: Journal of the Peripheral Nervous System: JPNS
https://www.readbyqxmd.com/read/28476398/a-wound-complication-after-percutaneous-achilles-tendon-lengthening-requiring-surgical-excision-a-case-report
#20
Tiffany K Hoh, Rex W Hung, John S Steinberg, Katherine M Raspovic
A percutaneous tendo-Achilles lengthening procedure corrects limited ankle joint equinus by decreasing the pull of the triceps surae complex. The standard technique using 3-incision hemisection described by Hoke is often used in patients with diabetes because of the minimal number of incisions and low risk of wound complications. We describe a patient who underwent percutaneous tendo-Achilles lengthening with a resultant open wound complication requiring staged surgical debridement.
May 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
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