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Jeanine F Amacher, Fangfang Zhong, George P Lisi, Michael Q Zhu, Stephanie L Alden, Kevin R Hoke, Dean R Madden, Ekaterina V Pletneva
No abstract text is available yet for this article.
March 19, 2018: Journal of the American Chemical Society
Morgan K Hoke, Kimberly A McCabe, Aaron A Miller, Thomas W McDade
OBJECTIVE: To validate a method for measuring endotoxin-core antibodies (EndoCAb) from dried blood spots (DBS)-drops of capillary whole blood collected and dried on filter paper-as an indicator of environmental enteropathy (EE) in infancy and early childhood. METHODS: A commercially available enzyme immunoassay kit was adapted for use with DBS, with optimized steps for sample elution. Technical validation included analysis of linearity/recovery, precision and reliability, lower limit of detection, and correspondence between matched plasma and DBS samples...
March 13, 2018: American Journal of Human Biology: the Official Journal of the Human Biology Council
Tae Chung, Yanli Tian, Jeremy Walston, Ahmet Hoke
OBJECTIVE: Age-associated skeletal muscle weakness is a major contributing factor to an increased late life mortality and morbidity, but its neurobiology is poorly understood. Previously, we provided histological evidence of dying-back axonal degeneration of motor neurons and denervation of neuromuscular junctions (NMJ) in age-associated muscle weakness. Given this, we aim to evaluate the relation between impaired neuromuscular transmission and various aspects of age-associated muscle weakness...
March 1, 2018: American Journal of Physical Medicine & Rehabilitation
Ricardo H Roda, Brett A McCray, Christopher J Klein, Ahmet Hoke
No abstract text is available yet for this article.
February 2018: Neurology. Genetics
Seoung-Ryoung Choi, Bradley E Britigan, Barbara Switzer, Traci Hoke, David Moran, Prabagaran Narayanasamy
The nontuberculous mycobacterial (NTM) pathogens, M. avium complex (MAC) and M. abscessus, can result in severe pulmonary infections. Current antibiotics confront significant challenges for treatment of these NTM infections due to emerging multidrug-resistance. Thus, development of new antibiotics targeted against these agents is needed. We examined the inhibitory activities of Ga(NO3 )3 , GaCl3 , gallium meso-tetraphenylporphyrine (GaTP), and gallium nanoparticles (GaNP) against intra- and extracellular M...
March 5, 2018: Molecular Pharmaceutics
Nabarun Chakraborty, Amrita Cheema, Aarti Gautam, Duncan Donohue, Allison Hoke, Carolynn Conley, Marti Jett, Rasha Hammamieh
Spaceflight presents a spectrum of stresses very different from those associated with terrestrial conditions. Our previous study (BMC Genom. 15: 659, 2014) integrated the expressions of mRNAs, microRNAs, and proteins and results indicated that microgravity induces an immunosuppressive state that can facilitate opportunistic pathogenic attack. However, the existing data are not sufficient for elucidating the molecular drivers of the given immunosuppressed state. To meet this knowledge gap, we focused on the metabolite profile of spaceflown human cells...
2018: NPJ Microgravity
Nicole Hoke
No abstract text is available yet for this article.
February 2018: AORN Journal
Molly C Womack, Tyler S Fiero, Kim L Hoke
The repeated, independent evolution of traits (convergent evolution) is often attributed to shared environmental selection pressures. However, developmental dependencies among traits can limit the phenotypic variation available to selection and bias evolutionary outcomes. Here we determine how changes in developmentally correlated traits may impact convergent loss of the tympanic middle ear, a highly labile trait within toads that currently lack adaptive explanation. The middle ear's lability could reflect evolutionary trade-offs with other skull features under selection, or the middle ear may evolve independently of the rest of the skull, allowing it to be modified by active or passive processes without pleiotropic trade-offs with other skull features...
January 31, 2018: Evolution; International Journal of Organic Evolution
Ulas Höke, Jeroen J Bax, Victoria Delgado, Nina Ajmone Marsan
BACKGROUND: Systolic dyssynchrony index (SDI) using three-dimensional echocardiography (3DE) was shown to be a reliable measure of left ventricular (LV) dyssynchrony. However, the prognostic value of SDI on long-term outcomes after cardiac resynchronization therapy (CRT) remains unknown. METHODS AND RESULTS: A total of 414 patients (mean age 67±10 years, 60% ischemic etiology) with 3DE evaluation before CRT implantation were included. SDI was evaluated as continuous value and in quartiles...
January 29, 2018: Journal of Cardiovascular Electrophysiology
Tanya P Hoke, Howard Goldstein, Emily K Saks, Babak Vakili
STUDY OBJECTIVE: To evaluate surgical outcomes of a robotic sacrocolpopexy with and without a paravaginal repair for pelvic organ prolapse (POP) DESIGN: Retrospective cohort study with 3-month postoperative follow-up (Canadian Task Force II-3) SETTING: Academic-affiliated community hospital with a practice comprised of three surgeons board-certified in Female Pelvic Medicine and Reconstructive Surgery PATIENTS: Patients undergoing a robotic sacrocolpopexy for POP from April 2013 through November 2014...
January 22, 2018: Journal of Minimally Invasive Gynecology
Nina A Bickell, Jenny J Lin, Sarah R Abramson, Gerald P Hoke, William Oh, Simon J Hall, Richard Stock, Kezhen Fei, Ann Scheck McAlearney
PURPOSE: Black men are more likely to die as a result of prostate cancer than white men, despite effective treatments that improve survival for clinically significant prostate cancer. We undertook this study to identify gaps in prostate cancer care quality, racial disparities in care, and underlying reasons for poorer quality care. METHODS: We identified all black men and random age-matched white men with Gleason scores ≥ 7 diagnosed between 2006 and 2013 at two urban hospitals to determine rates of treatment underuse...
January 2018: Journal of Oncology Practice
Yutaro Kawazu, Hiroshi Hoke, Yasunori Yamada, Tatsuya Umecky, Kazuhiko Ozutsumi, Toshiyuki Takamuku
The thermodynamics of complex formation of Ni2+ with molecular liquids (ML), dimethyl sulfoxide (DMSO), methanol (MeOH), and acetonitrile (AN) in the ionic liquid (IL) of 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)amide ([C2 mim][TFSA]) has been elucidated using ultraviolet (UV)-visible spectroscopy. X-ray structural analyses for single crystals grown from Ni2+ -[C2 mim][TFSA]-DMSO and -AN solutions at high ML contents have shown that six DMSO oxygen or AN nitrogen atoms coordinate with Ni2+ to form octahedral structures of [Ni(dmso)6 ](TFSA)2 and [Ni(an)6 ](TFSA)2 , respectively...
November 29, 2017: Physical Chemistry Chemical Physics: PCCP
Phyllis Hoke, Mark Tiede, Julie Grender, Malgorzata Klukowska, Jill Peters, Gregory Carr
PURPOSE: To study the effects of denture adhesive upon denture micromovements in three dimensions during the chewing of hard, sticky, and tough food items observed using a novel method involving an electromagnetic articulograph (EMA) speech research system. MATERIALS AND METHODS: Ten volunteers (mean age 60.9 ± 10.4 years) with fair- or poor-fitting complete maxillary dentures were enrolled. Chewing experiments were conducted using two treatments (adhesive or no-adhesive control) and three foods: carrots (hard), raisins (sticky), and processed meat stick (tough)...
November 14, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
Mariappan Parans Paranthaman, Ling Li, Jiaqi Luo, Thomas Hoke, Huseyin Ucar, Bruce A Moyer, Stephen Harrison
We report a three-stage bench-scale column extraction process to selectively extract lithium chloride from geothermal brine. The goal of this research is to develop materials and processing technologies to improve the economics of lithium extraction and production from naturally occurring geothermal and other brines for energy storage applications. A novel sorbent, lithium aluminum layered double hydroxide chloride (LDH), is synthesized and characterized with X-ray powder diffraction, scanning electron microscopy, inductively coupled plasma optical emission spectrometry (ICP-OES), and thermogravimetric analysis...
November 9, 2017: Environmental Science & Technology
Macarena Perán, Elena López-Ruiz, María Ángel García, Shorena Nadaraia-Hoke, Ralf Brandt, Juan A Marchal, Julian Kenyon
Proteolytic enzymes have shown efficacy in cancer therapy. We present a combination of the two pro-enzymes Trypsinogen and Chymotrypsinogen A with potent in vitro and in vivo anti-tumour efficacy. A synergetic anti-tumour effect for Trypsinogen and Chymotrypsinogen A was determined at a ratio 1:6 (named PRP) using 24 human cancer cell lines. The antiangiogenic effect of PRP was analysed by matrigel-based tube formation and by fibrous capsule formation assays. Furthermore, cell invasion and wound healing assays together with qRT-PCR determination of epithelial-to-mesenchymal transition (EMT) markers were performed on human cancer cells treated with PRP...
October 25, 2017: Scientific Reports
Kim L Hoke, Eileen A Hebets, Daizaburo Shizuka
Animal behaviorists have long strived for a comprehensive understanding of the proximate and ultimate causes of complex behavior, and we propose that recent advances in neurobiology can help reshape or clarify this behavior-oriented understanding. We begin with an overview of current views of neural circuit mechanisms that mediate target selection and action selection. In target selection, different stimuli compete for priority in sensory-motor processing. Action selection is the process by which multiple possible motor actions compete for priority in a manner which balances the needs of the animal with opportunities or threats in the environment...
October 1, 2017: Integrative and Comparative Biology
E Francis, E Hivner, A Hoke, T Ricci, A Watach, J Kraschnewski
Background: In 2006, United States public schools participating in federal school meal programs were required to adopt school wellness policies. The effect of these policies on school nutrition environments is well documented; however, evaluation of physical activity policies has received less investigation. We aimed to evaluate how district wellness policies aligned to practice for physical activity implementation in 40 schools with high obesity rates (>24%). Methods: Wellness policies were evaluated using the validated Wellness School Assessment Tool (WellSAT)...
September 28, 2017: Journal of Public Health
Ulas Höke, Bart Mertens, Mand J H Khidir, Martin J Schalij, Jeroen J Bax, Victoria Delgado, Nina Ajmone Marsan
Individualized estimation of prognosis after cardiac resynchronization therapy (CRT) remains challenging. Our aim was to develop a multiparametric prognostic risk score (CRT-SCORE) that could be used for patient-specific clinical shared decision making about CRT implantation. The CRT-SCORE was derived from an ongoing CRT registry, including 1,053 consecutive patients (age 67 ± 10 years, 76% male). Using preimplantation variables, 100 multiple imputed datasets were generated for model calibration. Based on multivariate Cox regression models, cross-validated linear prognostic scores were calculated, as well as survival fractions at 1 and 5 years...
December 1, 2017: American Journal of Cardiology
Peter M Chapman, Richard A Brain, Jason B Belden, Valery E Forbes, Christopher A Mebane, Robert A Hoke, Gary T Ankley, Keith R Solomon
No abstract text is available yet for this article.
October 12, 2017: Integrated Environmental Assessment and Management
Charles C Williams, Jacob R Gdovin, Samuel J Wilson, Vanessa L Cazas-Moreno, John D Eason, Elizabeth L Hoke, Charles R Allen, Chip Wade, John C Garner
The purpose of this study was to investigate the effects of different warm-up (WU) devices on bat swing parameters including maximal resultant velocity (MRV), resultant velocity at ball contact (RVBC), time difference between MRV and RVBC, bat angle at MRV, bat angle at RVBC, and perceptual differences (PD) of each WU implement utilized by National Collegiate Athletic Association (NCAA) Division-I baseball players. Fifteen varsity baseball players completed one experimental session during fall training. Retro-reflective markers were placed on the bat and tee to measure basic bat kinematics during the swing...
June 3, 2017: Journal of Strength and Conditioning Research
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