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Methotrexate and surgery

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https://www.readbyqxmd.com/read/27893545/effects-of-preoperative-methotrexate-on-complications-after-surgery-for-inflammatory-bowel-disease
#1
De-Jun Cui, Xiao-Lan Yang, Mei Hu, Liu-Chan Yang
No abstract text is available yet for this article.
November 22, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27891402/clinical-analysis-of-ectopic-pregnancies-in-a-tertiary-care-centre-in-southern-india-a-six-year-retrospective-study
#2
S Tahmina, Mary Daniel, Preethy Solomon
INTRODUCTION: Ectopic Pregnancy (EP) is a life-threatening emergency commonly encountered by medical practitioners where diagnosis can often be missed. Any woman in the reproductive age group, presenting with lower abdominal pain or vaginal bleeding must raise the suspicion of an ectopic pregnancy to prevent mortality and morbidity. AIM: To review all cases of EP and determine the incidence of EP. To study the high risk factors and know the types of clinical presentation, methods of diagnosis, outcome and complications...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27867682/treatment-of-pregnant-women-with-a-diagnosis-of-inflammatory-bowel-disease
#3
REVIEW
Sule Poturoglu, Asli Ciftcibasi Ormeci, Ali Erkan Duman
The frequency of diagnosis of inflammatory bowel disease (IBD) has increased in younger populations. For this reason, pregnancy in patients with IBD is a topic of interest, warranting additional focus on disease management during this period. The main objective of this article is to summarize the latest findings and guidelines on the management of potential problems from pregnancy to the breastfeeding stage. Fertility is decreased in patients with active IBD. Disease remission prior to conception will likely decrease the rate of pregnancy-related complications...
November 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27858907/cholesterol-pericarditis-associated-with-rheumatoid-arthritis-a-rare-case-report
#4
Lin-Yan Qian, Jie Pang, Xian-Da Che, Ya-Hui Ding, Hai Zou, Bing Zhou
BACKGROUND: Cholesterol pericarditis (CP) is a special type of pericarditis. It is characterized by chronic pericardial effusion with high cholesterol concentration and with or without the formation of crystals in pericardial effusion. METHODS: In this case report, we described a 74-year-old male with massive pericardial effusion. He presented with no symptoms. However, he had 8-year history of rheumatoid arthritis medicated with methotrexate, celecoxib, and prednisone, and 5-year history of hypertension medicated with amlodipine besylate...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27847572/risk-factors-for-the-development-and-progression-of-atlantoaxial-subluxation-in-surgically-treated-rheumatoid-arthritis-patients-considering-the-time-interval-between-rheumatoid-arthritis-diagnosis-and-surgery
#5
Min-Kyun Na, Hyoung-Joon Chun, Koang-Hum Bak, Hyeong-Joong Yi, Je Il Ryu, Myung-Hoon Han
OBJECTIVE: Rheumatoid arthritis (RA) is a systemic disease that can affect the cervical spine, especially the atlantoaxial region. The present study evaluated the risk factors for atlantoaxial subluxation (AAS) development and progression in patients who have undergone surgical treatment. METHODS: We retrospectively analyzed the data of 62 patients with RA and surgically treated AAS between 2002 and 2015. Additionally, we identified 62 patients as controls using propensity score matching of sex and age among 12667 RA patients from a rheumatology registry between 2007 and 2015...
November 2016: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/27844211/morbid-obesity-and-outcome-of-ectopic-pregnancy-following-capped-single-dose-regimen-methotrexate
#6
Luis R Hoyos, Mokerrum Malik, Marvin Najjar, Javier Rodriguez-Kovacs, Mazen Abdallah, Gustavo Vilchez, Awoniyi O Awonuga
PURPOSE: Evaluate whether morbid obesity influenced resolution, number of doses or ultimately surgical management of tubal ectopic pregnancy (TEP) when treated with single-dose regimen methotrexate (SDR-MTX) capped at 100 mg. METHODS: Retrospective cohort study of patients with a diagnosis of TEP who underwent MTX treatment from 2000 to 2013. Patients were excluded if initial β-hCG <1000 mIU/mL, did not have β-hCG follow-up or were not treated with SDR-MTX...
November 14, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27793386/imelda-transvaginal-approach-to-ectopic-pregnancy-diagnosis-by-transvaginal-hydrolaparoscopy-and-treatment-by-transvaginal-natural-orifice-transluminal-endoscopic-surgery
#7
Jan Baekelandt, Jona Vercammen
OBJECTIVE: To demonstrate a new minimally invasive approach for the diagnosis and treatment of ectopic pregnancy. DESIGN: Stepwise explanation of the technique using original video footage. SETTING: Hospital. PATIENT(S): Since 2014, 15 patients were treated transvaginally for ectopic pregnancy and pregnancy of unknown location (PUL). INTERVENTION(S): In case of a diagnosis of ectopic pregnancy on ultrasound, a 2...
October 25, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27768157/initial-experience-with-low-dose-methotrexate-as-an-adjuvant-treatment-for-rapidly-recurrent-nonvasculitic-laryngotracheal-stenosis
#8
David E Rosow, Jamal Ahmed
Importance: Adult laryngotracheal stenosis (LTS) is typically managed surgically, but some patients fail treatment because of rapid restenosis or granulation tissue formation. The need for frequent surgery or tracheostomy reduces the quality of life in these patients and poses a significant challenge for the treating physician. New adjuvant treatments are required to reduce the surgical burden of this condition. Objective: To examine whether patients with rapidly recurrent nonvasculitic LTS who fail surgical management of their stenosis (ie, requiring dilation more frequently than every 6 months) experience longer intervals between surgical procedures when receiving adjuvant treatment with low-dose methotrexate...
October 20, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27756557/risk-adapted-single-agent-dactinomycin-or-carboplatin-for-second-line-treatment-of-methotrexate-resistant-low-risk-gestational-trophoblastic-neoplasia
#9
M C Winter, J A Tidy, A Hills, J Ireson, S Gillett, K Singh, B W Hancock, R E Coleman
OBJECTIVE: To evaluate the outcome of patients treated with second-line chemotherapy for methotrexate-resistant low-risk GTN at the Sheffield Centre, UK between 2001 and 2015, including the novel use of single-agent carboplatin as a strategy to reduce exposure to combination chemotherapy. METHODS: 392 low-risk GTN patients were treated with first-line methotrexate. The selection of chemotherapy regimen following methotrexate-resistance depended on the volume of residual disease as indicated by the serum hCG value at the time, with patients switching to either single-agent dactinomycin at an hCG level<150IU/L from 2001-2010 and <300IU/L since 2010, or to combination treatment with etoposide/dactinomycin (EA) above these thresholds...
December 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27754738/noninvasive-electroretinography-assessment-of-intravitreal-sustained-release-methotrexate-microimplants-in-rabbit-eyes
#10
Soumyarwit Manna, James J Augsburger, Zelia M Correa, Marwan F Al-Rjoub, Marepalli B Rao, Rupak K Banerjee
PURPOSE: The purpose of this study is to noninvasively evaluate the safety and toxicity of a chitosan (CS) and polylactic acid (PLA)-based sustained-release methotrexate (MTX) intravitreal microimplant in normal rabbit eyes using electroretinography (ERG). METHODS: PLA-coated CS-based microimplants containing 400 μg of MTX and placebo microimplants (without drug) were surgically implanted in the vitreous of the right and the left eyes, respectively, in each of the 8 New Zealand rabbits using minimally invasive technique...
October 18, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27731538/single-dose-systemic-methotrexate-versus-expectant-management-for-treatment-of-tubal-ectopic-pregnancy-a-placebo-controlled-randomised-trial
#11
D Jurkovic, M Memtsa, E Sawyer, Ana Donaldson, A Jamil, K Schramm, Y Sana, M Otify, L Farahani, N Nunes, G Ambler, J A Ross
OBJECTIVE: Methotrexate is routinely used worldwide for medical treatment of clinically stable women with tubal ectopic pregnancies. This is despite the lack of robust evidence to show its superior effectiveness over expectant management. The aim of our multicentre randomised trial study was to compare the success rates of methotrexate with placebo for the conservative treatment of tubal ectopic pregnancies. METHODS: The study was multicentre; it took place in three UK early pregnancy units between January 2006 and June 2014...
October 12, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27693933/comparison-of-systemic-and-local-methotrexate-treatments-in-cesarean-scar-pregnancies-time-to-change-conventional-treatment-and-follow-up-protocols
#12
Semih Z Uludag, Mehmet S Kutuk, Mehmet Ak, Mahmut T Ozgun, Mehmet Dolanbay, Ercan M Aygen, Yılmaz Sahin
OBJECTIVE: The aim of this study was to compare the use of systemic and local methotrexate in the treatment of cesarean scar pregnancy. STUDY DESIGN: In this retrospective cohort study, we collected the data of 44 patients with cesarean scar pregnancy. The patients were grouped according to treatment modality: Group 1, local methotrexate injection (n=17) and Group 2, systemic methotrexate (n=27). The groups were compared with respect to side effects, recovery time, reproductive outcome, and treatment cost...
November 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27648094/the-role-of-plasma-creatine-phosphokinase-cpk-level-in-prediction-of-response-to-methotrexate-for-ectopic-pregnancy
#13
Fatemeh Davari-Tanha, Mohadese Ghazi, Mona Mohseni, Farahnaz Ahmadi
Objective: To evaluate the plasma creatine phosphokinase (CPK) level after injection of methotrexate (MTX) as a predictor of treatment success in ectopic pregnancy (EP). Materials and methods: One hundred women treated with single dose of methotrexate for ectopic pregnancy were evaluated in a prospective study, for CPK and ß-subunit of human chorionic gonadotropin (ß-hCG) levels. They received intramuscular MTX at a dose of 50 mg/m2. The day of injection was considered as day 1 (D1). CPK level on the day of Methotrexate injection was compared between success group who were treated by a single MTX injection, and the unsuccessful groupwho were treated by two or three MTX injections or by surgery...
June 2016: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/27602071/curettage-after-uterine-artery-embolization-combined-with-methotrexate-treatment-for-caesarean-scar-pregnancy
#14
Ying Feng, Suwen Chen, Changdong Li, Xiaofeng Zhang, Hua Duan, Suren Sooranna, Mark R Johnson, Jian Li
In the present study, we evaluated the diagnosis and management modalities of caesarean scar pregnancy (CSP). Thirty patients diagnosed with CSP were retrospectively studied between February, 2010 and February, 2012. Twenty-five patients were offered prophylactic uterine artery embolization (UAE) and methotrexate (MTX) prior to uterine suction curettage. Five cases were referred from other hospitals where the initial management with uterine suction curettage had resulted in uncontrollable massive haemorrhage, 4 of the cases had UAE and one proceeded immediately to hysterectomy...
September 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27599095/cataract-surgery-with-primary-lens-implantation-in-children-with-chronic-uveitis
#15
Damien Guindolet, Pascal Dureau, Céline Terrada, Catherine Edelson, Amandine Barjol, Georges Caputo, Phuc LeHoang, Bahram Bodaghi
PURPOSE: To evaluate the evolution of chronic uveitis in children undergoing cataract surgery with primary intraocular lens (IOL) implantation. METHODS: Twelve children with chronic uveitis underwent cataract surgery with primary posterior chamber intraocular lens (IOL) implantation. RESULTS: Fourteen eyes were implanted with a foldable hydrophobic acrylic IOL. The mean follow-up was 35.39 months (8.72-69.57). The mean BCDVA before surgery and at the end of follow-up was 1...
September 6, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27572300/overview-and-guidelines-of-off-label-use-of-methotrexate-in-ectopic-pregnancy-report-by-cngof
#16
REVIEW
Henri Marret, Arnaud Fauconnier, Gil Dubernard, Hélène Misme, Laurence Lagarce, Magali Lesavre, Hervé Fernandez, Camille Mimoun, Claire Tourette, Sandra Curinier, Benoit Rabishong, Aubert Agostini
Our objective is to describe off-label use of methotrexate in ectopic pregnancy treatment using evidence based medicine. The patient group includes all women with a pregnancy outside the usual endometrium, or of unknown location. Method used was a Medline search on ectopic pregnancy managed using methotrexate treatment; evidence synthesis was done based on this current literature analysis. Level of evidence (LE) were given according to the centre for evidence base medicine rules. Grade was proposed for guidelines but no recommendation was possible as misoprostol is off label use for all the indications studied...
October 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27566564/altered-ph-gradient-at-the-plasma-membrane-of-osteosarcoma-cells-is-a-key-mechanism-of-drug-resistance
#17
Sofia Avnet, Silvia Lemma, Margherita Cortini, Paola Pellegrini, Francesca Perut, Nicoletta Zini, Katsuyuki Kusuzaki, Tokuhiro Chano, Giulia Grisendi, Massimo Dominici, Angelo De Milito, Nicola Baldini
Current therapy of osteosarcoma (OS), the most common primary bone malignancy, is based on a combination of surgery and chemotherapy. Multidrug resistance mediated by P-glycoprotein (P-gp) overexpression has been previously associated with treatment failure and progression of OS, although other mechanisms may also play a role. We considered the typical acidic extracellular pH (pHe) of sarcomas, and found that doxorubicin (DXR) cytotoxicity is reduced in P-gp negative OS cells cultured at pHe 6.5 compared to standard 7...
August 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27566557/candidate-germline-polymorphisms-of-genes-belonging-to-the-pathways-of-four-drugs-used-in-osteosarcoma-standard-chemotherapy-associated-with-risk-survival-and-toxicity-in-non-metastatic-high-grade-osteosarcoma
#18
Claudia M Hattinger, Paola Biason, Erika Iacoboni, Sara Gagno, Marilù Fanelli, Elisa Tavanti, Serena Vella, Stefano Ferrari, Andrea Roli, Rossana Roncato, Luciana Giodini, Katia Scotlandi, Piero Picci, Giuseppe Toffoli, Massimo Serra
This study aimed to identify associations between germline polymorphisms and risk of high-grade osteosarcoma (HGOS) development, event-free survival (EFS) and toxicity in HGOS patients treated with neo-adjuvant chemotherapy and surgery.Germline polymorphisms of 31 genes known to be relevant for transport or metabolism of all four drugs used in HGOS chemotherapy (methotrexate, doxorubicin, cisplatin and ifosfamide) were genotyped in 196 patients with HGOS and in 470 healthy age and gender-matched controls. Of these 196 HGOS patients, a homogeneously treated group of 126 patients was considered for survival analyses (survival cohort)...
August 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27544880/robotic-assisted-laparoscopic-treatment-of-residual-ectopic-pregnancy-in-a-previous-cesarean-section-scar-a-case-report
#19
Andy Schmitt, Patrice Crochet, Aubert Agostini
STUDY OBJECTIVE: To describe a technique of robotic-assisted laparoscopy of residual caesarean scar pregnancy (CSP) and uterine defect repair. DESIGN: Video case report. Step-by-step explanation of the procedure (Canadian Task Force classification III) SETTING: Cesarean scar pregnancy (CSP) may be treated by different approaches including surgery and methotrexate. Successful methotrexate treatments avoid an emergency surgical treatment. In these cases a residual CSP often remains and should be removed in women who desire to conceive...
August 17, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27544879/laparoscopic-management-of-an-invasive-mole-perforating-the-uterus
#20
Leonti Grin, Ahmed Namazov, Michael Volodarsky, Eyal Anteby, Ofer Lavie, Ofer Gemer
STUDY OBJECTIVE: To show the possibility of conservative laparoscopic management in a case of invasive mole perforating the uterus DESIGN: Video with explanations. SETTING: An invasive mole could potentially become a life threatening complication of gestational trophoblastic disease (1). This is a Case of a 24 y/o presented with abdominal pain and vaginal bleeding. Sonography demonstrated large amount of fluid and a 3x3cm heterogeneous lesion next to the posterior uterine wall...
August 17, 2016: Journal of Minimally Invasive Gynecology
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