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https://www.readbyqxmd.com/read/29221774/sleep-dependent-motor-sequence-memory-consolidation-in-individuals-with-periodic-limb-movements
#1
Valya Sergeeva, Jeremy Viczko, Laura B Ray, Adrian M Owen, Stuart M Fogel
Periodic limb movements (PLMs) during sleep increase with age and are associated with striatal neurodegeneration and dopamine deficiency. Limb movements are often associated with disruptions to non-rapid eye movement (NREM) sleep. Motor skill memory consolidation recruits the striatum, and learning-dependent striatal activation is associated with NREM sleep. Therefore, we investigated whether de novo individuals who significantly experience elevated levels of PLMs but have not been formally diagnosed with periodic limb movement disorder had learning and sleep-related memory deficits and whether these deficits were related to sleep quality and symptom severity...
December 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29220862/a-descriptive-analysis-of-sleep-and-wakefulness-states-during-maternal-behaviors-in-postpartum-rats
#2
L Benedetto, M Rivas, M Pereira, A Ferreira, P Torterolo
Mother rats spend most of their time nursing their litter during the early stages of the postpartum period, only occasionally leaving the nest. The suckling stimulus from the pups elicits the adoption of nursing postures, during which milk ejection occurs, an event associated with the occurrence of non-REM (NREM) sleep in the rat. Despite this evidence, the characteristics of sleep during different nursing postures along the postpartum period remain unknown. The present study aims to describe the sleep pattern of mother rats while nursing, hovering over their pups and when being away from the pups...
September 1, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/29217404/high-density-eeg-characterization-of-brain-responses-to-auditory-rhythmic-stimuli-during-wakefulness-and-nrem-sleep
#3
Caroline Lustenberger, Yogi A Patel, Sankaraleengam Alagapan, Jessica M Page, Betsy Price, Michael R Boyle, Flavio Frohlich
Auditory rhythmic sensory stimulation modulates brain oscillations by increasing phase-locking to the temporal structure of the stimuli and by increasing the power of specific frequency bands, resulting in Auditory Steady State Responses (ASSR). The ASSR is altered in different diseases of the central nervous system such as schizophrenia. However, in order to use the ASSR as biological markers for disease states, it needs to be understood how different vigilance states and underlying brain activity affect the ASSR...
December 4, 2017: NeuroImage
https://www.readbyqxmd.com/read/29205292/brain-regions-and-epileptogenicity-influence-epileptic-interictal-spike-production-and-propagation-during-nrem-sleep-in-comparison-with-wakefulness
#4
Isabelle Lambert, Nicolas Roehri, Bernard Giusiano, Romain Carron, Fabrice Wendling, Christian Benar, Fabrice Bartolomei
OBJECTIVE: Non-rapid eye movement (NREM) sleep is known to be a brain state associated with an activation of interictal epileptic activity. The goal of this work was to quantify topographic changes occurring during NREM sleep in comparison with wakefulness. METHOD: We studied intracerebral recordings of 20 patients who underwent stereo-electroencephalography (SEEG) during presurgical evaluation for pharmacoresistant focal epilepsy. We measured the number of interictal spikes (IS) and quantified the co-occurrence of IS between brain regions during 1 hour of NREM sleep and 1 hour of wakefulness...
December 3, 2017: Epilepsia
https://www.readbyqxmd.com/read/29196666/sigma-frequency-dependent-motor-learning-in-williams-syndrome
#5
Andrea Berencsi, Róbert Bódizs, Ferenc Gombos, Szandra László, Ilona Kovács
There are two basic stages of fine motor learning: performance gain might occur during practice (online learning), and improvement might take place without any further practice (offline learning). Offline learning, also called consolidation, has a sleep-dependent stage in terms of both speed and accuracy of the learned movement. Sleep spindle or sigma band characteristics affect motor learning in typically developing individuals. Here we ask whether the earlier found, altered sigma activity in a neurodevelopmental disorder (Williams syndrome, WS) predicts motor learning...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29186205/narcolepsy-susceptibility-gene-ccr3-modulates-sleep-wake-patterns-in-mice
#6
Hiromi Toyoda, Yoshiko Honda, Susumu Tanaka, Taku Miyagawa, Makoto Honda, Kazuki Honda, Katsushi Tokunaga, Tohru Kodama
Narcolepsy is caused by the loss of hypocretin (Hcrt) neurons and is associated with multiple genetic and environmental factors. Although abnormalities in immunity are suggested to be involved in the etiology of narcolepsy, no decisive mechanism has been established. We previously reported chemokine (C-C motif) receptor 3 (CCR3) as a novel susceptibility gene for narcolepsy. To understand the role of CCR3 in the development of narcolepsy, we investigated sleep-wake patterns of Ccr3 knockout (KO) mice. Ccr3 KO mice exhibited fragmented sleep patterns in the light phase, whereas the overall sleep structure in the dark phase did not differ between Ccr3 KO mice and wild-type (WT) littermates...
2017: PloS One
https://www.readbyqxmd.com/read/29171396/sleep-related-hypermotor-epilepsy-activated-by-rapid-eye-movement-sleep
#7
Xiaoli Wang, Lara V Marcuse, Lang Jin, Ying Zhang, Wenjuan Zhang, Beibei Chen, Na Yuan, Bi Wang, Yonghong Liu
Most sleep-related seizures occur during non-rapid eye movement (NREM) sleep, particularly during stage changes. Sleep-related hypermotor epilepsy (SHE) is a rare epileptic syndrome characterized by paroxysmal motor seizures, mainly arising from NREM sleep. Here, we report a patient with SHE who had seven seizures captured on video-EEG-polysomnography during REM sleep. Ictal semiology of this patient ranged from brief paroxysmal arousals to hypermotor seizures. On EEG-polysomnography, the spontaneous arousals were more frequent during REM than NREM sleep, with a considerably higher arousal index in REM sleep (20/hour)...
November 24, 2017: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/29170000/sleep-disorder-and-altered-locomotor-activity-as-biomarkers-of-the-parkinson-s-disease-cholinopathy-in-rat
#8
Jelena Ciric, Katarina Lazic, Slobodan Kapor, Milka Perovic, Jelena Petrovic, Vesna Pesic, Selma Kanazir, Jasna Saponjic
In order to find out the possible earliest biomarkers of Parkinson's disease (PD) cholinopathy, we followed the impact of bilateral pedunculopontine tegmental nucleus (PPT) lesion in rat on: the cortical and hippocampal sleep/wake states architectures, all sleep states related EEG microstructures, sleep spindles, the basal and stimulated locomotor activity. Sleep and basal locomotor activity in adult Wistar rats were followed during their inactive circadian phase, and throughout the same aging period. The bilateral PPT lesions were done by 0...
November 20, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29162522/loss-of-consciousness-is-related-to-hyper-correlated-gamma-band-activity-in-anesthetized-macaques-and-sleeping-humans
#9
Michał Bola, Adam B Barrett, Andrea Pigorini, Lino Nobili, Anil K Seth, Artur Marchewka
Loss of consciousness can result from a wide range of causes, including natural sleep and pharmacologically induced anesthesia. Important insights might thus come from identifying neuronal mechanisms of loss and re-emergence of consciousness independent of a specific manipulation. Therefore, to seek neuronal signatures of loss of consciousness common to sleep and anesthesia we analyzed spontaneous electrophysiological activity recorded in two experiments. First, electrocorticography (ECoG) acquired from 4 macaque monkeys anesthetized with different anesthetic agents (ketamine, medetomidine, propofol) and, second, stereo-electroencephalography (sEEG) from 10 epilepsy patients in different wake-sleep stages (wakefulness, NREM, REM)...
November 21, 2017: NeuroImage
https://www.readbyqxmd.com/read/29157585/cardiac-autonomic-control-during-sleep-in-patients-with-myotonic-dystrophy-type-1-the-effects-of-comorbid-obstructive-sleep-apnea
#10
Eleonora Tobaldini, Giorgio Colombo, Monica Solbiati, Chiara Cogliati, Lucia Morandi, Alessandro Pincherle, Nicola Montano
OBJECTIVE: Myotonic dystrophy type 1 (DM1) is a hereditary myopathy characterized by an autosomal dominant inheritance with important cardiovascular and autonomic deregulation. DM1 patients have a high prevalence of obstructive sleep apnea (OSA), but the effects of this comorbidity on cardiovascular autonomic control (CAC) are unknown. The present study aimed to investigate CAC during sleep-wake cycle in DM1 patients, taking into account the effects of OSA comorbidity. METHOD: Twenty-three patients with a diagnosis of DM1, and a control group, underwent a complete polysomnographic study (PSG)...
November 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29112823/obstructive-sleep-apnea-during-rapid-eye-movement-sleep-and-cardiovascular-disease
#11
R Nisha Aurora, Ciprian Crainiceanu, Daniel J Gottlieb, Ji Soo Kim, Naresh M Punjabi
BACKGROUND: Obstructive sleep apnea (OSA) during rapid eye movement (REM) sleep is a common disorder. Data on whether OSA that occurs predominantly during REM sleep is associated with health outcomes are limited. The present study examined the association between OSA during REM sleep and a composite cardiovascular endpoint in a community sample with and without prevalent cardiovascular disease. METHODOLOGY: Full montage home polysomnography was conducted as part of the Sleep Heart Health Study...
November 7, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29101338/in-human-non-rem-sleep-more-slow-wave-activity-leads-to-less-blood-flow-in-the-prefrontal-cortex
#12
Laura Tüshaus, Ximena Omlin, Ruth O'Gorman Tuura, Andrea Federspiel, Roger Luechinger, Philipp Staempfli, Thomas Koenig, Peter Achermann
Cerebral blood flow (CBF) is related to integrated neuronal activity of the brain whereas EEG provides a more direct measurement of transient neuronal activity. Therefore, we addressed what happens in the brain during sleep, combining CBF and EEG recordings. The dynamic relationship of CBF with slow-wave activity (SWA; EEG sleep intensity marker) corroborated vigilance state specific (i.e., wake, non-rapid eye movement (NREM) sleep stages N1-N3, wake after sleep) differences of CBF e.g. in the posterior cingulate, basal ganglia, and thalamus, indicating their role in sleep-wake regulation and/or sleep processes...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29095855/impaired-memory-consolidation-in-children-with-obstructive-sleep-disordered-breathing
#13
Kiran Maski, Erin Steinhart, Hannah Holbrook, Eliot S Katz, Kush Kapur, Robert Stickgold
Memory consolidation is stabilized and even enhanced by sleep (and particularly by 12-15 Hz sleep spindles in NREM stage 2 sleep) in healthy children but it is unclear what happens to these processes when sleep is disturbed by obstructive sleep disordered breathing. This cross-sectional study investigates differences in declarative memory consolidation among children with primary snoring (PS) and obstructive sleep apnea (OSA) compared to controls. We further investigate whether memory consolidation group differences are associated with NREM stage 2 (N2) sigma (12-15 Hz) or NREM slow oscillation (0...
2017: PloS One
https://www.readbyqxmd.com/read/29093451/sleep-benefits-memory-for-semantic-category-structure-while-preserving-exemplar-specific-information
#14
Anna C Schapiro, Elizabeth A McDevitt, Lang Chen, Kenneth A Norman, Sara C Mednick, Timothy T Rogers
Semantic memory encompasses knowledge about both the properties that typify concepts (e.g. robins, like all birds, have wings) as well as the properties that individuate conceptually related items (e.g. robins, in particular, have red breasts). We investigate the impact of sleep on new semantic learning using a property inference task in which both kinds of information are initially acquired equally well. Participants learned about three categories of novel objects possessing some properties that were shared among category exemplars and others that were unique to an exemplar, with exposure frequency varying across categories...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29081090/sinomenine-an-alkaloid-derived-from-sinomenium-acutum-potentiates-pentobarbital-induced-sleep-behaviors-and-non-rapid-eye-movement-nrem-sleep-in-rodents
#15
Jae Hyeon Yoo, Tae-Woo Ha, Jin Tae Hong, Ki-Wan Oh
Sinomenium acutum has been long used in the preparations of traditional medicine in Japan, China and Korea for the treatment of various disorders including rheumatism, fever, pulmonary diseases and mood disorders. Recently, it was reported that Sinomenium acutum, has sedative and anxiolytic effects mediated by GABA-ergic systems. These experiments were performed to investigate whether sinomenine (SIN), an alkaloid derived from Sinomenium acutum enhances pentobarbital-induced sleep via γ-aminobutyric acid (GABA)-ergic systems, and modulates sleep architecture in mice...
November 1, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29080930/dysfunction-of-gabaergic-neurons-in-the-parafacial-zone-mediates-sleep-disturbances-in-a-streptozotocin-induced-rat-model-of-sporadic-alzheimer-s-disease
#16
Jin-Zhi Song, Su-Ying Cui, Xiang-Yu Cui, Xiao Hu, Yu-Nu Ma, Hui Ding, Hui Ye, Yong-He Zhang
Sleep disturbances are prevalent among patients with Alzheimer's disease (AD) and often precede the onset and progression of dementia. However, there are no reliable animal models for investigating sleep disturbances in patients with sporadic AD (sAD), which accounts for more than 90% of all AD cases. In the present study, we characterize the sleep/wake cycles and explore a potential mechanism underlying sleep disturbance in a rat model of sAD induced via intracerebroventricular (icv) injection of streptozotocin (STZ)...
October 28, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29079823/sex-differences-in-light-sensitivity-impact-on-brightness-perception-vigilant-attention-and-sleep-in-humans
#17
Sarah L Chellappa, Roland Steiner, Peter Oelhafen, Christian Cajochen
Artificial light endows a "round-the-clock", 24-h/7-d society. Chronic exposure to light at night contributes to health hazards for humans, including disorders of sleep. Yet the influence of inter-individual traits, such as sex-differences, on light sensitivity remains to be established. Here we investigated potential sex-differences to evening light exposure of 40 lx at 6500 K (blue-enriched) or at 2500 K (non-blue-enriched), and their impact on brightness perception, vigilant attention and sleep physiology...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29077507/multi-ethnic-meta-analysis-identifies-rai1-as-a-possible-obstructive-sleep-apnea-related-quantitative-trait-locus-in-men
#18
Han Chen, Brian E Cade, Kevin J Gleason, Andrew C Bjonnes, Adrienne M Stilp, Tamar Sofer, Matthew P Conomos, Sonia Ancoli-Israel, Raanan Arens, Ali Azarbarzin, Graeme I Bell, Jennifer E Below, Sung Chun, Daniel S Evans, Ralf Ewert, Alexis C Frazier-Wood, Sina A Gharib, José Haba-Rubio, Erika W Hagen, Raphael Heinzer, David R Hillman, W Craig Johnson, Zoltan Kutalik, Jacqueline M Lane, Emma K Larkin, Seung Ku Lee, Jingjing Liang, Jose S Loredo, Sutapa Mukherjee, Lyle J Palmer, George J Papanicolaou, Thomas Penzel, Paul E Peppard, Wendy S Post, Alberto R Ramos, Ken Rice, Jerome I Rotter, Scott A Sands, Neomi A Shah, Chol Shin, Katie L Stone, Beate Stubbe, Jae-Hoon Sul, Mehdi Tafti, Kent D Taylor, Alexander Teumer, Timothy A Thornton, Gregory J Tranah, Chaolong Wang, Heming Wang, Simon C Warby, D Andrew Wellman, Phyllis C Zee, Craig L Hanis, Cathy C Laurie, Daniel J Gottlieb, Sanjay R Patel, Xiaofeng Zhu, Shamil R Sunyaev, Richa Saxena, Xihong Lin, Susan Redline
Obstructive sleep apnea (OSA) is a common heritable disorder displaying marked sexual dimorphism in disease prevalence and progression. Previous genetic association studies have identified a few genetic loci associated with OSA and related quantitative traits, but they have only focused on single ethnic groups and a large proportion of the heritability remains unexplained. The apnea hypopnea index (AHI) is a commonly used quantitative measure characterizing OSA severity. Since OSA differs by sex, and the pathophysiology of obstructive events differ in rapid eye movement (REM) and non-REM (NREM) sleep, we hypothesized that additional genetic association signals would be identified by analyzing the NREM/REM-specific AHI and by conducting sex-specific analyses in multi-ethnic samples...
October 27, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29066952/the-sleep-wake-cycle-in-the-nicotinic-alpha-9-acetylcholine-receptor-subunit-knock-out-mice
#19
Natalia Madrid-López, Jorge Estrada, Javier Díaz, Alejandro Bassi, Paul H Délano, Adrián Ocampo-Garcés
There is a neural matrix controlling the sleep-wake cycle (SWC) embedded within high ranking integrative mechanisms in the central nervous system. Nicotinic alpha-9 acetylcholine receptor subunit (alpha-9 nAChR) participate in physiological processes occurring in sensory, endocrine and immune systems. There is a relationship between the SWC architecture, body homeostasis and sensory afferents so that disruption of afferent signaling is expected to affect the temporal organization of sleep and wake states. The analysis of the SWC of 9 nAChR knock-out animals may help to reveal the contribution of alpha-9 nAChR to sleep chronobiological determinants...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29060486/characterizing-the-nrem-rem-sleep-specific-obstructive-sleep-apnea-severity-using-snore-sounds
#20
S Akhter, U R Abeyratne, V Swarnker
Obstructive Sleep Apnea (OSA) patients have frequent breathing obstructions and upper airway (UA) collapse during sleep. It is clinically important to estimate OSA severity separately for Rapid Eye Movement (REM) and non-REM (NREM) sleep states, but the task requires Polysomnography (PSG) which uses about 15-20 body contact sensors and subjective assessment. Almost all OSA patients snore. Vibration in narrowed UA muscles cause snoring in OSA. Moreover, as sleep states are associated with distinct breathing patterns and UA muscle tone, REM/NREM specific information must be available via snore/breathing sounds...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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