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https://www.readbyqxmd.com/read/29892048/thalamic-dual-control-of-sleep-and-wakefulness
#1
Thomas C Gent, Mojtaba Bandarabadi, Carolina Gutierrez Herrera, Antoine R Adamantidis
Slow waves (0.5-4 Hz) predominate in the cortical electroencephalogram during non-rapid eye movement (NREM) sleep in mammals. They reflect the synchronization of large neuronal ensembles alternating between active (UP) and quiescent (Down) states and propagating along the neocortex. The thalamic contribution to cortical UP states and sleep modulation remains unclear. Here we show that spontaneous firing of centromedial thalamus (CMT) neurons in mice is phase-advanced to global cortical UP states and NREM-wake transitions...
June 11, 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29885049/diurnal-changes-in-glutamate-glutamine-levels-of-healthy-young-adults-assessed-by-proton-magnetic-resonance-spectroscopy
#2
Carina Volk, Valeria Jaramillo, Renato Merki, Ruth O'Gorman Tuura, Reto Huber
The glutamatergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor is involved in synaptic plasticity processes, and animal studies have demonstrated altered expression across the sleep wake cycle. Accordingly, glutamate levels are reduced during non-rapid eye movement (NREM) sleep and the rate of this decrease is positively correlated with sleep EEG slow wave activity (SWA). Here, we combined proton magnetic resonance spectroscopy (1 H-MRS) and high-density sleep EEG to assess if 1 H-MRS is sensitive to diurnal changes of glutamate + glutamine (GLX) in healthy young adults and if potential overnight changes of GLX are correlated to SWA...
June 8, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29879654/visually-detected-non-rapid-eye-movement-stage-2-sleep-spindle-density-at-age-five-years-predicted-prosocial-behavior-positively-and-hyperactivity-scores-negatively-at-age-nine-years
#3
Thorsten Mikoteit, Serge Brand, Sonja Perren, Agnes von Wyl, Kai von Klitzing, Jennifer Kurath, Edith Holsboer-Trachsler, Martin Hatzinger
OBJECTIVE: A higher density of sleep electroencephalogram (EEG) spindles has been cross-sectionally associated with more efficient cortical-subcortical connectivity, superior intellectual and learning abilities, and healthier emotional and behavioral traits. In the present study, we explored to what extent sleep spindle density (SSD) at age five years could predict emotional and behavioral traits at six and nine years. METHODS: A total of 19 healthy preschoolers at age five years underwent in-home sleep EEG recordings for visual scoring of non-rapid eye movement stage 2 (NREM-S2) sleep spindles, and SSD in NREM-S2 was calculated...
April 25, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29872141/mice-lacking-alternatively-activated-m2-macrophages-show-impairments-in-restorative-sleep-after-sleep-loss-and-in-cold-environment
#4
Ashley Massie, Erin Boland, Levente Kapás, Éva Szentirmai
The relationship between sleep, metabolism and immune functions has been described, but the cellular components of the interaction are incompletely identified. We previously reported that systemic macrophage depletion results in sleep impairment after sleep loss and in cold environment. These findings point to the role of macrophage-derived signals in maintaining normal sleep. Macrophages exist either in resting form, classically activated, pro-inflammatory (M1) or alternatively activated, anti-inflammatory (M2) phenotypes...
June 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29860401/the-association-between-white-matter-and-sleep-spindles-differs-in-young-and-older-individuals
#5
Pierre-Olivier Gaudreault, Nadia Gosselin, Marjolaine Lafortune, Samuel Deslauriers-Gauthier, Nicolas Martin, Maude Bouchard, Jonathan Dubé, Jean-Marc Lina, Julien Doyon, Julie Carrier
Study Objectives: Sleep is a reliable indicator of cognitive health in older individuals. Sleep spindles (SS) are non-rapid-eye-movement (NREM) sleep oscillations implicated in sleep-dependent learning. Their generation imply a complex activation of the thalamo-cortico-thalamic loop. Since SS require neuronal synchrony, the integrity of the white matter (WM) underlying these connections is of major importance. During aging, both SS and WM undergo important changes. The goal of this study was to investigate whether WM integrity could predict the age-related reductions in SS characteristics...
May 31, 2018: Sleep
https://www.readbyqxmd.com/read/29859261/standing-sentinel-during-human-sleep-continued-evaluation-of-environmental-stimuli-in-the-absence-of-consciousness
#6
Christine Blume, Renata Del Giudice, Malgorzata Wislowska, Dominik P J Heib, Manuel Schabus
While it is a well-established finding that subject's own names (SON) or familiar voices are salient during wakefulness, we here investigated processing of environmental stimuli during sleep including deep N3 and REM sleep. Besides the effects of sleep depth we investigated how sleep-specific EEG patterns (i.e. sleep spindles and slow oscillations [SOs]) relate to stimulus processing. Using 256-channel EEG we studied processing of auditory stimuli by means of event-related oscillatory responses (de-/synchronisation, ERD/ERS) and potentials (ERPs) in N = 17 healthy sleepers...
May 30, 2018: NeuroImage
https://www.readbyqxmd.com/read/29844415/regulation-of-cortical-activity-and-arousal-by-the-matrix-cells-of-the-ventromedial-thalamic-nucleus
#7
Sakiko Honjoh, Shuntaro Sasai, Shannon S Schiereck, Hirotaka Nagai, Giulio Tononi, Chiara Cirelli
The "non-specific" ventromedial thalamic nucleus (VM) has long been considered a candidate for mediating cortical arousal due to its diffuse, superficial projections, but direct evidence was lacking. Here, we show in mice that the activity of VM calbindin1-positive matrix cells is high in wake and REM sleep and low in NREM sleep, and increases before cortical activity at the sleep-to-wake transition. Optogenetic stimulation of VM cells rapidly awoke all mice from NREM sleep and consistently caused EEG activation during slow wave anesthesia, while arousal did not occur from REM sleep...
May 29, 2018: Nature Communications
https://www.readbyqxmd.com/read/29804297/a-single-episode-of-binge-alcohol-drinking-causes-sleep-disturbance-disrupts-sleep-homeostasis-and-downregulates-equilibrative-nucleoside-transporter-1
#8
Rishi Sharma, Pradeep Sahota, Mahesh M Thakkar
Binge alcohol drinking, a risky pattern of alcohol consumption, has severe consequences toward health and well-being of an individual, his family and society. Although, binge drinking has detrimental effects on sleep, underlying mechanisms are unknown. We used adult male C57BL/6J mice and exposed them to a single, four-hour session of binge alcohol self-administration, in stress-free environment, to examine neuronal mechanisms affecting sleep. We first verified binge pattern of alcohol consumption. When allowed to self-administer alcohol in a non-stressful environment, mice consumed alcohol in a binge pattern...
May 27, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29803760/prolonged-partial-obstruction-during-sleep-is-a-nrem-phenomenon
#9
Sari-Leena Himanen, Lauri Martikkala, Saramia Sulkamo, Antti Rutanen, Eero Huupponen, Mirja Tenhunen, Tiia Saunamäki
OBJECTIVE: Prolonged partial obstruction (PPO) is a common finding in sleep studies. Although not verified, it seems to emerge in deep sleep. We study the effect of PPO on sleep architecture or sleep electroencephalography (EEG) frequency. METHODS: Fifteen OSA patients, 15 PPO + OSA patients and 15 healthy subjects underwent a polysomnography. PPO was detected from Emfit mattress signal. Visual sleep parameters and median NREM sleep frequency of the EEG channels were evaluated...
May 24, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29803181/evaluation-of-an-automated-pipeline-for-large-scale-eeg-spectral-analysis-the-national-sleep-research-resource
#10
Sara Mariani, Leila Tarokh, Ina Djonlagic, Brian E Cade, Michael G Morrical, Kristine Yaffe, Katie L Stone, Kenneth A Loparo, Shaun M Purcell, Susan Redline, Daniel Aeschbach
STUDY OBJECTIVES: We present an automated sleep electroencephalogram (EEG) spectral analysis pipeline that includes an automated artifact detection step, and we test the hypothesis that spectral power density estimates computed with this pipeline are comparable to those computed with a commercial method preceded by visual artifact detection by a sleep expert (standard approach). METHODS: EEG data were analyzed from the C3-A2 lead in a sample of polysomnograms from 161 older women participants in a community-based cohort study...
November 29, 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29796717/the-sleep-disorder-in-anti-lglon5-disease
#11
REVIEW
Carles Gaig, Alex Iranzo, Joan Santamaria, Francesc Graus
PURPOSE OF REVIEW: To review the clinical and polysomnographic features of the sleep disorder occurring in the recently described anti-IgLON5 disease. The hallmark of the disease is the presence of antibodies against IgLON5, a neural cell adhesion molecule of unknown function. The disease presents a robust HLA association, and the neuropathological examination shows a novel neuronal tauopathy with predominant hypothalamic and brainstem involvement. RECENT FINDINGS: Most patients (> 80%) present sleep-related vocalizations with movements and behaviors and sleep-disordered breathing...
May 23, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29780880/circadian-and-brain-state-modulation-of-network-hyperexcitability-in-alzheimer-s-disease
#12
Rosalind Brown, Alice D Lam, Alfredo Gonzalez-Sulser, Andrew Ying, Mary Jones, Robert Chang-Chih Chou, Makis Tzioras, Crispin Y Jordan, Izabela Jedrasiak-Cape, Anne-Laure Hemonnot, Maurice Abou Jaoude, Andrew J Cole, Sydney S Cash, Takashi Saito, Takaomi Saido, Richard R Ribchester, Kevan Hashemi, Iris Oren
Network hyperexcitability is a feature of Alzheimer' disease (AD) as well as numerous transgenic mouse models of AD. While hyperexcitability in AD patients and AD animal models share certain features, the mechanistic overlap remains to be established. We aimed to identify features of network hyperexcitability in AD models that can be related to epileptiform activity signatures in AD patients. We studied network hyperexcitability in mice expressing amyloid precursor protein (APP) with mutations that cause familial AD, and compared a transgenic model that overexpresses human APP (hAPP) (J20), to a knock-in model expressing APP at physiological levels (APPNL/F )...
March 2018: ENeuro
https://www.readbyqxmd.com/read/29773213/sleep-structure-and-awakening-threshold-in-delayed-sleep-wake-phase-disorder-patients-compared-to-healthy-sleepers
#13
Brandy Solheim, Knut Langsrud, Håvard Kallestad, Morten Engstrøm, Bjørn Bjorvatn, Trond Sand
STUDY OBJECTIVES: Difficult early morning awakening is a primary symptom of delayed sleep-wake phase disorder (DSWPD), however, it remains poorly investigated. Our main objective was to quantify the awakening threshold in DSWPD-patients and healthy controls as well as investigate a possible relationship with sleep stages. A secondary objective was to compare habitual sleep measured by polysomnography and actigraphy between patients and controls. METHODS: Twenty DSWPD patients and 16 controls had two polysomnographic recordings at a sleep laboratory...
June 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29771034/-a-preliminary-clinical-classification-study-in-rem-related-obstructive-sleep-apnea
#14
K L Jiang, L Zhao, S N Li, Z Q Lin, Y M Ma, M A Iqbal, W Qian
Objective: The aim of this study is to introduce a method in classifying the REM related OSA (RrOSA) and the potential clinical significance. Method: Two hundred and fifty patients (male: 219) with OSAS diagnosed by polysomnographywere recruited in the study. The RrOSAS was defined as the ratio of AHIs in REM and non REM sleep (R) greater than one. In RrOSAS group, patients were divided into RrOSAS Ⅰa (R>2, NREM_AHI<15), RrOSAS Ⅰb (R>2, NREM_AHI>15), and RrOSAS II (2>R>1) three subtypes...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29764203/pinellia-ternata-thunb-makino-preparation-promotes-sleep-by-increasing-rem-sleep
#15
Sisi Lin, Bo Nie, Guihong Yao, Hui Yang, Ren Ye, Zhengzhong Yuan
Pinellia ternata (Thunb.) Makino Preparation (PTP) is widely used to treat insomnia in traditional Chinese medicine; however, its specific role is not clear. In this study, PTP was prepared at three concentrations. For locomotor activity tests, mice were treated with PTP and evaluated for 14 days. For polygraph recordings, mice were treated for 14 days and recorded after treatment. The main chemical constituents in PTP were identified by Ultra performance liquid chromatography/quadrupole time spectrometry (UPLC/Q-TOF-MS)...
May 15, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29758338/how-do-children-fall-asleep-a-high-density-eeg-study-of-slow-waves-in-the-transition-from-wake-to-sleep
#16
Mathilde Spiess, Giulio Bernardi, Salome Kurth, Maya Ringli, Flavia M Wehrle, Oskar G Jenni, Reto Huber, Francesca Siclari
INTRODUCTION: Slow waves, the hallmarks of non-rapid eye-movement (NREM) sleep, are thought to reflect maturational changes that occur in the cerebral cortex throughout childhood and adolescence. Recent work in adults has revealed evidence for two distinct synchronization processes involved in the generation of slow waves, which sequentially come into play in the transition to sleep. In order to understand how these two processes are affected by developmental changes, we compared slow waves between children and young adults in the falling asleep period...
May 17, 2018: NeuroImage
https://www.readbyqxmd.com/read/29753639/nrem-parasomnias-a-treatment-approach-based-upon-a-retrospective-case-series-of-512-patients
#17
Panagis Drakatos, Lucy Marples, Rexford Muza, Sean Higgins, Nadia Gildeh, Raluca Macavei, Eptehal M Dongol, Alexander Nesbitt, Ivana Rosenzweig, Elaine Lyons, Grainne d'Ancona, Joerg Steier, Adrian J Williams, Brian D Kent, Guy Leschziner
BACKGROUND: Non-REM parasomnias are not uncommon conditions in the general population. Current treatment options are based on small case series and reports. In this study, we aimed to present the clinical experience from a large cohort of patients. PATIENTS: Five hundred and twelve patients with Non-REM parasomnia or parasomnia overlap disorder (POD), who had undergone a video polysomnography and were exposed to treatment, were retrospectively identified. Treatment outcome was assessed based on patients' reports, and treatment approach on a locally accepted hierarchy of interventions...
April 10, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29746591/brown-adipose-tissue-plays-a-central-role-in-systemic-inflammation-induced-sleep-responses
#18
Éva Szentirmai, Levente Kapás
We previously identified brown adipose tissue (BAT) as a source of sleep-inducing signals. Pharmacological activation of BAT enhances sleep while sleep loss leads to increased BAT thermogenesis. Recovery sleep after sleep loss is diminished in mice that lack uncoupling protein 1 (UCP-1), and also in wild-type (WT) mice after sensory denervation of the BAT. Systemic inflammation greatly affects metabolism and the function of adipose tissue, and also induces characteristic sleep responses. We hypothesized that sleep responses to acute inflammation are mediated by BAT-derived signals...
2018: PloS One
https://www.readbyqxmd.com/read/29743546/heritability-of-sleep-eeg-topography-in-adolescence-results-from-a-longitudinal-twin-study
#19
Andjela Markovic, Peter Achermann, Thomas Rusterholz, Leila Tarokh
The topographic distribution of sleep EEG power is a reflection of brain structure and function. The goal of this study was to examine the degree to which genes contribute to sleep EEG topography during adolescence, a period of brain restructuring and maturation. We recorded high-density sleep EEG in monozygotic (MZ; n = 28) and dizygotic (DZ; n = 22) adolescent twins (mean age = 13.2 ± 1.1 years) at two time points 6 months apart. The topographic distribution of normalized sleep EEG power was examined for the frequency bands delta (1-4...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29741725/ventilatory-control-sensitivity-in-patients-with-obstructive-sleep-apnea-is-sleep-stage-dependent
#20
Shane A Landry, Christopher Andara, Philip I Terrill, Simon A Joosten, Paul Leong, Dwayne L Mann, Scott A Sands, Garun S Hamilton, Bradley A Edwards
Study Objectives: The severity of obstructive sleep apnea (OSA) is known to vary according to sleep stage; however, the pathophysiology responsible for this robust observation is incompletely understood. The objective of the present work was to examine how ventilatory control system sensitivity (i.e. loop gain) varies during sleep in patients with OSA. Methods: Loop gain was estimated using signals collected from standard diagnostic polysomnographic recordings performed in 44 patients with OSA...
May 1, 2018: Sleep
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