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https://www.readbyqxmd.com/read/28229642/sleep-loss-and-recovery-after-administration-of-drugs-related-to-different-arousal-systems-in-rats
#1
T Hajnik, A Tóth, Ö Szalontai, M Pethő, L Détári
Sleep is homeostatically regulated suggesting a restorative function. Sleep deprivation is compensated by an increase in length and intensity of sleep. In this study, suppression of sleep was induced pharmacologically by drugs related to different arousal systems. All drugs caused non-rapid eye movement (NREM) sleep loss followed by different compensatory processes. Apomorphine caused a strong suppression of sleep followed by an intense recovery. In the case of fluoxetine and eserine, recovery of NREM sleep was completed by the end of the light phase due to the biphasic pattern demonstrated for these drugs first in the present experiments...
September 2016: Physiol Int
https://www.readbyqxmd.com/read/28227613/sleep-stage-classification-by-non-contact-vital-signs-indices-using-doppler-radar-sensors
#2
Masayuki Kagawa, Kazuki Suzumura, Takemi Matsui, Masayuki Kagawa, Kazuki Suzumura, Takemi Matsui, Kazuki Suzumura, Takemi Matsui, Masayuki Kagawa
Disturbed sleep has become more common in recent years. To improve the quality of sleep, undergoing sleep observation has gained interest as a means to resolve possible problems. In this paper, we evaluate a non-restrictive and non-contact method for classifying real-time sleep stages and report on its potential applications. The proposed system measures heart rate (HR), heart rate variability (HRV), body movements, and respiratory signals of a sleeping person using two 24-GHz microwave radars placed beneath the mattress...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227112/estimation-of-macro-sleep-stages-from-whole-night-audio-analysis
#3
E Dafna, M Halevi, D Ben Or, A Tarasiuk, Y Zigel, E Dafna, M Halevi, D Ben Or, A Tarasiuk, Y Zigel, D Ben Or, Y Zigel, M Halevi, E Dafna, A Tarasiuk
During routine sleep diagnostic procedure, sleep is broadly divided into three states: rapid eye movement (REM), non-REM (NREM) states, and wake, frequently named macro-sleep stages (MSS). In this study, we present a pioneering attempt for MSS detection using full night audio analysis. Our working hypothesis is that there might be differences in sound properties within each MSS due to breathing efforts (or snores) and body movements in bed. In this study, audio signals of 35 patients referred to a sleep laboratory were recorded and analyzed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227111/sleep-stage-recognition-using-respiration-signal
#4
Jialei Yang, James M Keller, Mihail Popescu, Marjorie Skubic, Jialei Yang, James M Keller, Mihail Popescu, Marjorie Skubic, James M Keller, Mihail Popescu, Marjorie Skubic, Jialei Yang
This paper presents a sleep stage recognition system for Awake, rapid eye movement (REM) and non-REM (NREM) sleep detection. Two respiratory variability (RV) features are extracted from oro-nasal airflow signals provided in the sleep-EDF (Expanded) database. A two layer system with threshold comparison classifier is implemented. This system achieved state-of-the-art performance with simple features and classifiers. The average accuracy of 74.00%±5.30% and Cohen's kappa coefficient of 0.49±0.08 were achieved with 21 recordings...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227110/bioradiolocation-based-sleep-stage-classification
#5
Alexander Tataraidze, Lyudmila Korostovtseva, Lesya Anishchenko, Mikhail Bochkarev, Yurii Sviryaev, Sergey Ivashov, Alexander Tataraidze, Lyudmila Korostovtseva, Lesya Anishchenko, Mikhail Bochkarev, Yurii Sviryaev, Sergey Ivashov, Mikhail Bochkarev, Yurii Sviryaev, Lesya Anishchenko, Lyudmila Korostovtseva, Sergey Ivashov, Alexander Tataraidze
This paper presents a method for classifying wakefulness, REM, light and deep sleep based on the analysis of respiratory activity and body motions acquired by a bioradar. The method was validated using data of 32 subjects without sleep-disordered breathing, who underwent a polysomnography study in a sleep laboratory. We achieved Cohen's kappa of 0.49 in the wake-REM-light-deep sleep classification, 0.55 for the wake-REM-NREM classification and 0.57 for the sleep/wakefulness determination. The results might be useful for the development of unobtrusive sleep monitoring systems for diagnostics, prevention, and management of sleep disorders...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227109/probabilistic-characterization-of-sleep-architecture-home-based-study-on-healthy-volunteers
#6
Gary Garcia-Molina, Sreeram Vissapragada, Anandi Mahadevan, Robert Goodpaster, Brady Riedner, Michele Bellesi, Giulio Tononi, Gary Garcia-Molina, Sreeram Vissapragada, Anandi Mahadevan, Robert Goodpaster, Brady Riedner, Michele Bellesi, Giulio Tononi, Robert Goodpaster, Brady Riedner, Michele Bellesi, Giulio Tononi, Gary Garcia-Molina, Sreeram Vissapragada, Anandi Mahadevan
The quantification of sleep architecture has high clinical value for diagnostic purposes. While the clinical standard to assess sleep architecture is in-lab based polysomnography, higher ecological validity can be obtained with multiple sleep recordings at home. In this paper, we use a dataset composed of fifty sleep EEG recordings at home (10 per study participant for five participants) to analyze the sleep stage transition dynamics using Markov chain based modeling. The statistical analysis of the duration of continuous sleep stage bouts is also analyzed to identify the speed of transition between sleep stages...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28215249/altered-sleep-architecture-during-the-first-months-of-life-in-infants-born-to-depressed-mothers
#7
Flora Bat-Pitault, Gianluca Sesso, Christine Deruelle, Sophie Flori, Véronique Porcher-Guinet, Camille Stagnara, Aurore Guyon, Sabine Plancoulaine, Joëlle Adrien, David Da Fonseca, Hugues Patural, Patricia Franco
OBJECTIVE: This study investigated sleep architecture in newborn and six-month-old infants who were born to depressed mothers. METHOD: Sixty-four healthy full-term infants (32 males and 32 females) participated in the study. Of these, 32 were high-risk infants who were born to mothers diagnosed with depression, and 32 were low-risk infants born to mothers without a personal history of depression. 24-hour polysomnography was recorded at zero and six months of age (M0 and M6)...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28215233/task-switching-in-older-adults-with-and-without-insomnia
#8
Kristine A Wilckens, Martica H Hall, Kirk I Erickson, Anne Germain, Vishwajit L Nimgaonkar, Timothy H Monk, Daniel J Buysse
BACKGROUND: Task-switching deficits are common in older adults and in those with insomnia. Such deficits may be driven by difficulties with sleep continuity and dampened homeostatic sleep drive. OBJECTIVE: To identify the aspects of task switching affected by insomnia and its treatment, and to determine whether such effects are associated with sleep continuity and homeostatic sleep drive. METHODS: Polysomnographic sleep and task switching were tested in healthy older adults aged 60-93 years with insomnia (n = 48) and normal sleeping controls (n = 51)...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28123649/sexsomnia-and-rem-predominant-obstructive-sleep-apnea-effectively-treated-with-a-mandibular-advancement-device
#9
Miguel Meira E Cruz, Rodolfo Soca
Parasomnias with sexual behavior or sexsomnias are considered a subtype of NREM parasomnias. Obstructive sleep apnea/hypopnea (OSAH) has been described as a known triggering factor for parasomnias including sexsomnia. Nasal continuous positive airway pressure (nCPAP) has been the standard of treatment for OSAH but mandibular advancement devices (MAD) are becoming an important treatment alternative. We present the case of a patient with mild OSAH and sexsomnia who had resolution of both conditions with a MAD...
July 2016: Sleep Science
https://www.readbyqxmd.com/read/28117135/sleep-regulation-physiology-and-development-sleep-duration-and-patterns-and-sleep-hygiene-in-infants-toddlers-and-preschool-age-children
#10
Eleanor Bathory, Suzy Tomopoulos
Sleep problems are common, reported by a quarter of parents with children under the age of 5 years, and have been associated with poor behavior, worse school performance, and obesity, in addition to negative secondary effects on maternal and family well-being. Yet, it has been shown that pediatricians do not adequately address sleep in routine well-child visits, and underdiagnose sleep issues. Pediatricians receive little formal training in medical school or in residency regarding sleep medicine. An understanding of the physiology of sleep is critical to a pediatrician׳s ability to effectively and confidently counsel patients about sleep...
January 20, 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/28112177/adenosine-a2a-receptor-deficiency-attenuates-the-somnogenic-effect-of-prostaglandin-d2-in-mice
#11
Bin-Jia Zhang, Zhi-Li Huang, Jiang-Fan Chen, Yoshihiro Urade, Wei-Min Qu
Prostaglandin D2 (PGD2) is one of the most potent endogenous sleep promoting substances. PGD2 activates the PGD2 receptor (DPR) and increases the extracellular level of adenosine in wild-type (WT) mice but not DPR knockout (KO) mice, suggesting that PGD2-induced sleep is DPR-dependent, and adenosine may be the signaling molecule that mediates the somnogenic effect of PGD2. The aim of this study was to determine the involvement of the adenosine A2A receptor (A2AR) in PGD2-induced sleep.We infused PGD2 into the lateral ventricle of WT and A2AR KO mice between 20:00 and 2:00 for 6 h, and electroencephalograms and electromyograms were simultaneously recorded...
January 23, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28109896/the-nlrp3-inflammasome-modulates-sleep-and-nrem-sleep-delta-power-induced-by-spontaneous-wakefulness-sleep-deprivation-and-lipopolysaccharide
#12
Mark R Zielinski, Dmitry Gerashchenko, Svetlana A Karpova, Varun Konanki, Robert W McCarley, Fayyaz S Sutterwala, Robert E Strecker, Radhika Basheer
Both sleep loss and pathogens can enhance brain inflammation, sleep, and sleep intensity as indicated by electroencephalogram delta (δ) power. The pro-inflammatory cytokine interleukin-1 beta (IL-1β) is increased in the cortex after sleep deprivation (SD) and in response to the Gram-negative bacterial cell-wall component lipopolysaccharide (LPS), although the exact mechanisms governing these effects are unknown. The nucleotide-binding domain and leucine-rich repeat protein-3 (NLRP3) inflammasome protein complex forms in response to changes in the local environment and, in turn, activates caspase-1 to convert IL-1β into its active form...
January 18, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28098351/the-elicitation-of-steady-state-visual-evoked-potentials-during-sleep
#13
James J S Norton, Stephen Umunna, Timothy Bretl
This study confirmed the hypothesis that it is possible to elicit SSVEPs through closed eyelids during NREM sleep. To test this hypothesis, SSVEP amplitudes were measured in eight subjects across two conditions of stimulation (stimulation on and stimulation off) and three brain states (waking, light sleep, and deep sleep). Results showed a significant interaction between stimulation and brain state. In particular, EEG activity at the frequency of stimulation was higher during both light sleep and deep sleep in the stimulation on condition than in the stimulation off condition...
January 18, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28092583/deep-learning-and-insomnia-assisting-clinicians-with-their-diagnosis
#14
Mostafa Shahin, Beena Ahmed, Sana Tmar-Ben Hamida, Fathima Mulaffer, Martin Glos, Thomas Penzel
Effective sleep analysis is hampered by the lack of automated tools catering for disordered sleep patterns and cumbersome monitoring hardware. In this paper, we apply deep learning on a set of 57 EEG features extracted from a maximum of two EEG channels to accurately differentiate between patients with insomnia or controls with no sleep complaints. We investigated two different approaches to achieve this. The first approach used EEG data from the whole sleep recording irrespective of the sleep stage (stage-independent classification), while the second used only EEG data from insomnia-impacted specific sleep stages (stage-dependent classification)...
January 9, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28088873/developmental-changes-in-ultradian-sleep-cycles-across-early-childhood
#15
Sean Lopp, William Navidi, Peter Achermann, Monique LeBourgeois, Cecilia Diniz Behn
Nocturnal human sleep is composed of cycles between rapid eye movement (REM) sleep and non-REM (NREM) sleep. In adults, the structure of ultradian cycles between NREM and REM sleep is well characterized; however, less is known about the developmental trajectories of ultradian sleep cycles across early childhood. Cross-sectional studies indicate that the rapid ultradian cycling of active-quiet sleep in infancy shifts to a more adult-like pattern of NREM-REM sleep cycling by the school-age years, yet longitudinal studies elucidating the details of this transition are scarce...
January 1, 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/28087252/novel-method-for-evaluation-of-eye-movements-in-patients-with-narcolepsy
#16
Julie A E Christensen, Lykke Kempfner, Helle L Leonthin, Mathias Hvidtfelt, Miki Nikolic, Birgitte Rahbek Kornum, Poul Jennum
BACKGROUND: Narcolepsy causes abnormalities in the control of wake-sleep, non-rapid-eye-movement (non-REM) sleep and REM sleep, which includes specific eye movements (EMs). In this study, we aim to evaluate EM characteristics in narcolepsy as compared to controls using an automated detector. METHODS: We developed a data-driven method to detect EMs during sleep based on two EOG signals recorded as part of a polysomnography (PSG). The method was optimized using the manually scored hypnograms from 36 control subjects...
December 21, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/28077261/ventral-medullary-control-of-rapid-eye-movement-sleep-and-atonia
#17
Michael C Chen, Ramalingam Vetrivelan, Chun-Ni Guo, Catie Chang, Patrick M Fuller, Jun Lu
Discrete populations of neurons at multiple levels of the brainstem control rapid eye movement (REM) sleep and the accompanying loss of postural muscle tone, or atonia. The specific contributions of these brainstem cell populations to REM sleep control remains incompletely understood. Here we show in rats that viral vector-based lesions of the ventromedial medulla at a level rostral to the inferior olive (pSOM) produced violent myoclonic twitches and abnormal electromyographic spikes, but not complete loss of tonic atonia, during REM sleep...
April 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28070566/interleukin-37-expression-in-mice-alters-sleep-responses-to-inflammatory-agents-and-influenza-virus-infection
#18
Christopher J Davis, Mark R Zielinski, Danielle Dunbrasky, Ping Taishi, Charles A Dinarello, James M Krueger
Multiple interactions between the immune system and sleep are known, including the effects of microbial challenge on sleep or the effects of sleep loss on facets of the immune response. Cytokines regulate, in part, sleep and immune responses. Here we examine the role of an anti-inflammatory cytokine, interleukin-37 (IL-37) on sleep in a mouse strain that expresses human IL-37b (IL37tg mice). Constitutive expression of the IL-37 gene in the brains of these mice under resting conditions is low; however, upon an inflammatory stimulus, expression increases dramatically...
June 2017: Neurobiology of Sleep and Circadian Rhythms
https://www.readbyqxmd.com/read/28066138/potentiation-of-decursinol-angelate-on-pentobarbital-induced-sleeping-behaviors-via-the-activation-of-gabaa-ergic-systems-in-rodents
#19
Jae Hoon Woo, Tae-Woo Ha, Jae-Seon Kang, Jin Tae Hong, Ki-Wan Oh
Angelicae Gigantis Radix (AGR, Angelica gigas) has been used for a long time as a traditional folk medicine in Korea and oriental countries. Decursinol angelate (DCA) is structurally isomeric decursin, one of the major components of AGR. This study was performed to confirm whether DCA augments pentobarbital-induced sleeping behaviors via the activation of GABAA-ergic systems in animals. Oral administration of DCA (10, 25 and 50 mg/kg) markedly suppressed spontaneous locomotor activity. DCA also prolonged sleeping time, and decreased the sleep latency by pentobarbital (42 mg/kg), in a dose-dependent manner, similar to muscimol, both at the hypnotic (42 mg/kg) and sub-hypnotic (28 mg/kg) dosages...
January 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28060294/manipulation-of-epileptiform-electrocorticograms-ecogs-and-sleep-in-rats-and-mice-by-acupuncture
#20
Pei-Lu Yi, Shuo-Bin Jou, Yi-Jou Wu, Fang-Chia Chang
Ancient Chinese literature has documented that acupuncture possesses efficient therapeutic effects on epilepsy and insomnia. There is, however, little research to reveal the possible mechanisms behind these effects. To investigate the effect of acupuncture on epilepsy and sleep, several issues need to be addressed. The first is to identify the acupoints, which correspond between humans, rats, and mice. Furthermore, the depth of insertion of the acupuncture needle, the degree of needle twist in manual needle acupuncture, and the stimulation parameters for electroacupuncture (EA) need to be determined...
December 22, 2016: Journal of Visualized Experiments: JoVE
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