Homone

Small-molecule capsid assembly modulators (CAMs) have been recently recognized as promising antiviral agents for curing chronic hepatitis B virus (HBV) infection. A target-based in silico screening study is described, aimed towards the discovery of novel HBV CAMs. Initial optimization of four weakly active screening hits was performed via focused library synthesis. Lead compound 42 and close analogues 56 and 57 exhibited in vitro potency in the sub- and micromolar range along with good physico-chemical properties and were further evaluated in molecular docking and mechanism of action studies...

Water spinach ( Ipomoea aquatica Forsk) is an essential green leafy vegetable in Asia. In this study, we induced autotetraploid water spinach by colchicine. Furthermore, DNA methylation and transcriptome of tetraploid and diploid were compared using Whole Genome Bisulfite Sequencing (WGBS) and RNA-sequencing techniques. Autotetraploid water spinach was created for the first time. Compared with the diploid parent, autotetraploid water spinach had wider leaves, thicker petioles and stems, thicker and shorter adventitious roots, longer stomas, and larger parenchyma cells...

PURPOSE OF REVIEW: Adrenal lesions are commonly discovered on abdominal imaging studies, whereas some patients with adrenal tumors present with symptoms of homonal excess. They are categorized as either hormone active or inactive and either as benign or malignant. This review is focused on the endocrine work up in patients with adrenal tumors. Knowledge of the use and limitations of hormonal assessment is essential for propper interpretation of the obtained test results. This article reviews which diagnostics are necessary to identify adrenal masses requiring treatment...

The hypothalamus and pituitary serve as important neuroendocrine center, which is able to secrete a variety of neuropeptides and hormones to participate in the regulation of reproduction, growth, stress and feeding in fish. Chinese sturgeon is a basal vertebrate lineage fish with a special evolutionary status, but the information on its neuroendocrine system is relatively scarce. Using the transcriptome data on the hypothalamus-pituitary axis of Chinese sturgeon as reference, we found out 46 hypothalamus neuropeptide genes, which were involved in regulation of reproduction, growth, stress and feeding...

This essay interrogates the representation of "hot mess" gay male castmates and their interpersonal relationships in LOGO's Fire Island ' s season 1. In particular, this essay identifies moments of media constructed queer failure through which the gay male castmates are framed, not to politicize, historicize, and contextualize their interpersonal relations as possibly emerging forms of queer relationalities. In so doing, this essay overall critiques how LOGO's Fire Island is a material product of homonationalism that colorblinds the hetero-relational paradigm as the normative social capital...

While there has been considerable interest in debates about right wing ideas in LGBT movements-military service, marriage, nationalism, white supremacy-there has been comparatively little attention to self-proclaimed right wing LGBT organizations, what I call the "gay right." Social theory to date offers a fragmented set of theoretical tools to explain them, including homonationalism, post-gay identity, additive intersectionality, and systems justification theory. I propose a two axis framework to unify these theories and map wide ranging diversity within the gay right...

The Indian Prime Minister, Narendra Modi, while addressing the United Nations General Assembly on 26 September 2020, stated that India had introduced legal reforms to accord rights to transgender citizens. Even though there is not much material basis to these rights, transgender communities have been protesting against the state and at times negotiating with it to get laws that are more in alignment with their rights. In the wake of serialised deaths and precarity intensified by the Covid-19 pandemic, transgender communities also stage other negotiations in the everyday with activists, transnationally funded NGOs and academics researching their communities, encounters that are not as spectacular as the protests against the state, but that which ensures their daily sustenance...

The incidence of venous thromboembolism (VTE) increases with age with an annual incidence of 1.25/1000 women in the 40-59 age group. Menopausal hormone therapy (MHT) may also increase the risk of VTE. This risk must be assessed during the first consultation before initiating MHT and assess each renewal of the MHT. MHT with oral estrogen combined (or not) with progestin increases the risk of VTE by about 70%. Using transdermal estrogen does not appear to increase the risk of VTE in women. VTE risk appears to be modulated by the type of progestin combined in MHT...

The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are released from enteroendocrine cells in response to the presence of nutrients in the small intestines. These homones facilitate glucose regulation by stimulating insulin secretion in a glucose dependent manner while suppressing glucagon secretion. In patients with type 2 diabetes (T2DM), an impaired insulin response to GLP-1 and GIP contributes to hyperglycemia. Dipeptidyl peptidase-4 (DPP-4) inhibitors block the breakdown of GLP-1 and GIP to increase levels of the active hormones...

This contribution explores the historical developments of transnational lesbian, gay, bisexual, transgender, and intersex (LGBTI) psychology in Colombia, the Philippines, Russia, and South Africa in relationship to U.S. LGBT psychology. LGBTI psychology in these diverse contexts share commonalities but also have important variations in their development and focus within LGBTI concerns. The International Psychology Network for Lesbian, Gay, Bisexual, Transgender and Intersex Issues (IPsyNet) provides a model for international professional psychology collaboration and linkage on behalf of advocacy for LGBTI rights and sexual orientation and gender identity and/or expression concerns...

The human infundibular nucleus (corresponding to the rodent arcuate nucleus) serves as an important integration center for neuronal signals and hormones released by peripheral endocrine organs. Kisspeptin (KP)-producing neurons of this anatomical site, many of which also synthesize neurokinin B (NKB), are critically involved in sex hormone signaling to gonadotropin-releasing hormone (GnRH) neurons. In recent years, the basic topography, morphology, neuropeptide content, and connectivity of human KP neurons have been investigated with in situ hybridization and immunohistochemistry on postmortem tissues...

The purpose of this study was to identify complex relationships between the mineral, organic component of bone and the risk of fractures under the influence of metabolic changes associated with type 2 diabetes. A cross-sectional study of patients diagnosed with T2DM (n=96) was conducted; control group, consisted of 82 individuals. All patients were studied calcitropic homons, serum bone remodeling markers and bone mineral density with (DXA). In the course of this study, there was a correlation between serum insulin levels, bone metabolism markers and bone mass density determined by lumbar DXA in patients with type 2 diabetes...

As apoptosis and genome instability in children with autoimmune diseases (AIDs) are insufficiently investigated, we aimed to analyse them in peripheral blood lymphocytes (PBLs) of children and adolescents with Hashimoto's thyroiditis (HT), Graves' disease (GD) and type 1 diabetes mellitus (T1DM), including possible factors that could affect their occurrence. The study population included 24 patients and 19 healthy controls. Apoptotic cells were detected using an Annexin V-FITC/7-AAD kit. Genome instability was measured as micronuclei (MNs) frequency using the cytokinesis-block MN assay...

OBJECTIVES: In vivo evaluations of a gonadotropin releasing hormone-receptor single photon emission computed tomography radiotracer for non-invasive detection of gonadotropin releasing homone-receptors in brain. RESULTS: We have used a simple, robust and high-yielding procedure to radiolabel an alpha-halogenated bioactive compound with high radiochemical yield. Literature findings showed similar alpha-halogenated compounds suitable for in vivo evaluations. The compound was found to possess nano molar affinity for the gonadotropin releasing hormone-receptor in a competition dependent inhibition study...

In this article we stress the need for specifically located understandings of the concept of homonationalism, by introducing an analysis of spatial and political power relations dissecting disparate constructions of LGBT arenas. The article explores three spaces: Tel-Aviv-an urban space of LGBT belonging; Jerusalem-the Israeli capital where being an LGBT individual is problematic both in public and in private spaces; and Kiryat-Shmona-a conservative and peripheral underprivileged town in the north of Israel...

The ability to advance puberty in broodstock that have a long generation interval and mature at large size is a highly valuable tool in contemporary aquaculture enterprise. Juvenile male and female wreckfish 'hāpuku' (Polyprion oxygeneios), a candidate for commercialization in aquaculture, were subjected to treatment for 8weeks with two implants, one containing steroid (blank; estradiol-17β, E2; 11-ketotestosterone, KT; 17 α-methyltestosterone, MT), the other peptide (blank; gonadotropin-releasing hormone analog, GnRHa; kisspeptin, Kiss2-12)...

This essay focuses on representations of Russia, the Soviet Union, and Eastern Europe in U.S. homophile periodicals from 1953 to 1964. Extending the application of Jasbir Puar's concept of homonationalism to the Cold War period, the essay examines 128 articles and other items that were published in ONE, Mattachine Review, and The Ladder and demonstrates that these periodicals often engaged in homonationalist discourses when constructing the Russian, Soviet, and Eastern European "other." Negative constructions of these regions were sometimes used to affirm the political alignment of the homophile authors with the American nation...

Pigment aggregation in shrimp chromatophores is triggered by red pigment concentrating hormone (RPCH), a neurosecretory peptide whose plasma membrane receptor may be a G-protein coupled receptor (GPCR). While RPCH binding activates the Ca2+ /cGMP signaling cascades, a role for cyclic AMP (cAMP) in pigment aggregation is obscure, as are the steps governing Ca2+ release from the smooth endoplasmic reticulum (SER). A role for the antagonistic neuropeptide, pigment dispersing homone (α-PDH) is also unclear...

Three experiments comparing four estrous synchronization protocols were conducted to determine estrous expression rate and artificial insemination pregnancy rate (AI-PR) in heifers with a range (1-5) of reproductive tract scores (RTSs). At enrollment (Day 0), 1783 Angus cross beef heifers from six locations were given body condition score and RTS. The four protocols were: (1) HRTS-DPGF group-heifers with RTS 5 received prostaglandin F2α (PGF; Dinoprost 25 mg; im) on Days 0 and 14; (2) HRTS-CIDR-PGF group-heifers with RTS 5 received a CIDR (1...

Premature ovarian insufficiency (POI) is defined by the presence of primary or secondary amenorrhea, for at least 4 months, before the age of 40 years associated with follicle stimulating homone levels in menopausal range, exciding 40 UI/L. The diagnosis is confirmed by two blood sample at least 1 month to measure the level of FSH (over 40 UI/L) and level of estradiol (below 50 pmol/L). Ovarian follicular dysfunction and/or depletion of functional primordial follicles characterized this pathology. Abnormal bleeding patterns also include oligomenrrhea and polimenorrhea; because of these irregular menstrual cycles during adolescence, diagnosis could be difficult in young women...