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Low field magnetic stimulation

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https://www.readbyqxmd.com/read/28068296/orientation-selective-deep-brain-stimulation
#1
Lauri J Lehto, Julia P Slopsema, Matthew D Johnson, Artem Shatillo, Benjamin A Teplitzky, Lynn Utecht, Gregor Adriany, Silvia Mangia, Alejandra Sierra, Walter C Low, Olli Gröhn, Shalom Michaeli
OBJECTIVE: Target selectivity of deep brain stimulation (DBS) therapy is critical, as the precise locus and pattern of the stimulation dictates the degree to which desired treatment responses are achieved and adverse side effects are avoided. There is a clear clinical need to improve DBS technology beyond currently available stimulation steering and shaping approaches. We introduce orientation selective neural stimulation as a concept to increase the specificity of target selection in DBS...
February 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28034451/predictors-of-response-to-repetitive-transcranial-magnetic-stimulation-rtms-in-the-treatment-of-major-depressive-disorder
#2
G Beuzon, Q Timour, M Saoud
Repetitive transcranial magnetic stimulation (rTMS), based on the principle of electromagnetic induction, consists of applying series of magnetic impulses to the cerebral cortex so as to modulate neurone activity in a target zone. This technique, still experimental, could prove promising in the field of psychiatry, in particular for the treatment of major depressive disorder. It is important for the clinician to be able to assess the response potential of a given patient to rTMS, and this among other things requires relevant predictive factors to be available...
December 26, 2016: L'Encéphale
https://www.readbyqxmd.com/read/28013233/the-influence-of-alertness-on-the-spatial-deployment-of-visual-attention-is-mediated-by-the-excitability-of-the-posterior-parietal-cortices
#3
Rebecca E Paladini, René M Müri, Jurka Meichtry, Tobias Nef, Fred W Mast, Urs P Mosimann, Thomas Nyffeler, Dario Cazzoli
With a reduced level of alertness, healthy individuals typically show a rightward shift when deploying visual attention in space. The impact of alertness on the neural networks governing visuospatial attention is, however, poorly understood. By using a transcranial magnetic stimulation twin-coil approach, the present study aimed at investigating the effects of an alertness manipulation on the excitability of the left and the right posterior parietal cortices (PPCs), crucial nodes of the visuospatial attentional network...
December 23, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/28011252/construction-and-modeling-of-a-reconfigurable-mri-coil-for-lowering-sar-in-patients-with-deep-brain-stimulation-implants
#4
Laleh Golestanirad, Maria Ida Iacono, Boris Keil, Leonardo M Angelone, Giorgio Bonmassar, Michael D Fox, Todd Herrington, Elfar Adalsteinsson, Cristen LaPierre, Azma Mareyam, Lawrence L Wald
Post-operative MRI of patients with deep brain simulation (DBS) implants is useful to assess complications and diagnose comorbidities, however more than one third of medical centers do not perform MRIs on this patient population due to stringent safety restrictions and liability risks. A new system of reconfigurable magnetic resonance imaging head coil composed of a rotatable linearly-polarized birdcage transmitter and a close-fitting 32-channel receive array is presented for low-SAR imaging of patients with DBS implants...
December 21, 2016: NeuroImage
https://www.readbyqxmd.com/read/28008663/detection-of-metabolite-changes-in-response-to-a-varying-visual-stimulation-paradigm-using-short-te-1-h-mrs-at-7%C3%A2-t
#5
Ralf Mekle, Simone Kühn, Harald Pfeiffer, Semiha Aydin, Florian Schubert, Bernd Ittermann
The two-fold benefit of (1) H magnetic resonance spectroscopy (MRS) at high B0 fields - enhanced sensitivity and increased spectral dispersion - has been used previously to study dynamic changes in metabolite concentrations in the human brain in response to visual stimulation. In these studies, a strong visual on/off stimulus was combined with MRS data acquisition in a voxel location in the occipital cortex determined by an initial functional magnetic resonance imaging experiment. However, 1) to exclude the possibility of systemic effects (heartbeat, blood flow, etc...
December 23, 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27942126/availability-usage-and-factors-affecting-usage-of-electrophysical-agents-by-physical-therapists-a-regional-cross-sectional-survey
#6
Yuichi Abe, Ah-Cheng Goh, Kei Miyoshi
[Purpose] The aim of this study was to investigate the availability, usage, and factors affecting usage of electrophysical agents by physical therapists in Nagano Prefecture, Japan. [Subjects and Methods] Questionnaires were sent to all 1,571 physical therapists working in 245 institutions within Nagano Prefecture. A total of 1,110 questionnaires were returned, out of which 1,099 (70%) questionnaires containing valid responses were analyzed. Frequencies and percentages were calculated for 22 modalities with regards to availability, usage, rate of usage, and confidence level in usage...
November 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27935011/electrical-stimulation-with-non-implanted-electrodes-for-overactive-bladder-in-adults
#7
REVIEW
Fiona Stewart, Luis F Gameiro, Regina El Dib, Monica O Gameiro, Anil Kapoor, Joao L Amaro
BACKGROUND: Several options exist for managing overactive bladder (OAB), including electrical stimulation (ES) with non-implanted devices, conservative treatment and drugs. Electrical stimulation with non-implanted devices aims to inhibit contractions of the detrusor muscle, potentially reducing urinary frequency and urgency. OBJECTIVES: To assess the effects of ES with non-implanted electrodes for OAB, with or without urgency urinary incontinence, compared with: placebo or any other active treatment; ES added to another intervention compared with the other intervention alone; different methods of ES compared with each other...
December 9, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27934961/minimum-electric-field-exposure-for-seizure-induction-with-electroconvulsive-therapy-and-magnetic-seizure-therapy
#8
Won Hee Lee, Sarah H Lisanby, Andrew F Laine, Angel V Peterchev
Lowering and individualizing the current amplitude in electroconvulsive therapy (ECT) has been proposed as a means to produce stimulation closer to the neural activation threshold and more focal seizure induction, which could potentially reduce cognitive side effects. However, the effect of current amplitude on the electric field (E-field) in the brain has not been previously linked to the current amplitude threshold for seizure induction. We coupled MRI-based E-field models with amplitude titrations of motor threshold (MT) and seizure threshold (ST) in four nonhuman primates (NHPs) to determine the strength, distribution, and focality of stimulation in the brain for four ECT electrode configurations (bilateral, bifrontal, right-unilateral, and frontomedial) and magnetic seizure therapy (MST) with cap coil on vertex...
December 9, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27893442/inconsistency-of-a-recently-proposed-method-for-assessing-magnetic-field-exposure-for-protection-against-peripheral-nerve-stimulation-in-occupational-situations
#9
Gernot Schmid, Rene Hirtl
A non-binding guide to practical implementation of European Directive 2013/35/EU concerning the limitation of occupational exposure against electromagnetic fields has been published recently. With regard to exposure assessment this guide proposes practically applicable assessment methods for non-uniform and non-sinusoidal environmental electric and magnetic fields, respectively. For non-sinusoidal magnetic fields in the low frequency range this guide proposes a time domain assessment (TDA) method, claimed to reduce the overestimation of exposure inherent to other assessment methods while being based on fundamental physiological principles regarding nerve stimulation...
November 28, 2016: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/27891079/contribution-of-tms-and-rtms-in-the-understanding-of-the-pathophysiology-and-in-the-treatment-of-dystonia
#10
REVIEW
Pierre Lozeron, Aurélia Poujois, Alexandra Richard, Sana Masmoudi, Elodie Meppiel, France Woimant, Nathalie Kubis
Dystonias represent a heterogeneous group of movement disorders responsible for sustained muscle contraction, abnormal postures, and muscle twists. It can affect focal or segmental body parts or be generalized. Primary dystonia is the most common form of dystonia but it can also be secondary to metabolic or structural dysfunction, the consequence of a drug's side-effect or of genetic origin. The pathophysiology is still not elucidated. Based on lesion studies, dystonia has been regarded as a pure motor dysfunction of the basal ganglia loop...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27884774/magnetically-responsive-multifunctional-drug-delivery-nanoparticles-for-elastic-matrix-regenerative-repair
#11
Balakrishnan Sivaraman, Ganesh Swaminathan, Lee Moore, Jonathan Fox, Dhruv Seshadri, Shataakshi Dahal, Ivan Stoilov, Maciej Zborowski, Robert Mecham, Anand Ramamurthi
: Arresting or regressing growth of abdominal aortic aneurysms (AAAs), localized expansions of the abdominal aorta are contingent on inhibiting chronically overexpressed matrix metalloproteases (MMPs)-2 and -9 that disrupt elastic matrix within the aortic wall, concurrent with providing a stimulus to augmenting inherently poor auto-regeneration of these matrix structures. In a recent study we demonstrated that localized, controlled and sustained delivery of doxycycline (DOX; a tetracycline-based antibiotic) from poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs), enhances elastic matrix deposition and MMP-inhibition at a fraction of the therapeutically effective oral dose...
November 21, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27875942/a-combined-study-of-meg-and-pico-tesla-tms-on-children-with-autism-disorder
#12
Photios Anninos, Athanasios Chatzimichael, Adam Adamopoulos, Athanasia Kotini, Nicolaos Tsagas
Magnetoencephalographic (MEG) recordings from the brain of 10 children with autism (6 boys and 4 girls, with ages range from 5-12 years, mean[Formula: see text][Formula: see text][Formula: see text]SD: 8.3[Formula: see text][Formula: see text][Formula: see text]2.1) were obtained using a whole-head 122-channel MEG system in a magnetically shielded room of low magnetic noise. A double-blind experimental design was used in order to look for possible effect of external pico-Tesla Transcranial Magnetic Stimulation (pT-TMS)...
November 23, 2016: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/27857683/in-vitro-magnetic-stimulation-a-simple-stimulation-device-to-deliver-defined-low-intensity-electromagnetic-fields
#13
Stephanie Grehl, David Martina, Catherine Goyenvalle, Zhi-De Deng, Jennifer Rodger, Rachel M Sherrard
Non-invasive brain stimulation (NIBS) by electromagnetic fields appears to benefit human neurological and psychiatric conditions, although the optimal stimulation parameters and underlying mechanisms remain unclear. Although, in vitro studies have begun to elucidate cellular mechanisms, stimulation is delivered by a range of coils (from commercially available human stimulation coils to laboratory-built circuits) so that the electromagnetic fields induced within the tissue to produce the reported effects are ill-defined...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27793904/pulsed-electromagnetic-field-with-temozolomide-can-elicit-an-epigenetic-pro-apoptotic-effect-on-glioblastoma-t98g-cells
#14
Francesca Pasi, Lorenzo Fassina, Maria Evelina Mognaschi, Giuseppe Lupo, Franco Corbella, Rosanna Nano, Enrica Capelli
Treatment with pulsed electromagnetic fields (PEMFs) is emerging as an interesting therapeutic option for patients with cancer. The literature has demonstrated that low-frequency/low-energy electromagnetic fields do not cause predictable effects on DNA; however, they can epigenetically act on gene expression. The aim of the present work was to study a possible epigenetic effect of a PEMF, mediated by miRNAs, on a human glioblastoma cell line (T98G). We tested a PEMF (maximum magnetic induction, 2 mT; frequency, 75 Hz) that has been demonstrated to induce autophagy in glioblastoma cells...
2016: Anticancer Research
https://www.readbyqxmd.com/read/27774373/miniature-atomic-scalar-magnetometer-for-space-based-on-the-rubidium-isotope-87-rb
#15
Haje Korth, Kim Strohbehn, Francisco Tejada, Andreas G Andreou, John Kitching, Svenja Knappe, S John Lehtonen, Shaughn M London, Matiwos Kafel
A miniature atomic scalar magnetometer based on the rubidium isotope (87)Rb was developed for operation in space. The instrument design implements both Mx and Mz mode operation and leverages a novel microelectromechanical system (MEMS) fabricated vapor cell and a custom silicon-on-sapphire (SOS) complementary metal-oxide-semiconductor (CMOS) integrated circuit. The vapor cell has a volume of only 1 mm(3) so that it can be efficiently heated to its operating temperature by a specially designed, low-magnetic-field-generating resistive heater implemented in multiple metal layers of the transparent sapphire substrate of the SOS-CMOS chips...
August 2016: Journal of Geophysical Research. Space Physics
https://www.readbyqxmd.com/read/27745724/-noninvasive-cerebral-stimulation-for-treatment-of-adhd-a-review-of-the-literature
#16
L Brandejsky, J-A Micoulaud Franchi, R Lopez, S Bioulac, D Da Fonseca, C Daudet, L Boyer, R Richieri, C Lançon
OBJECTIVES: The aim of this review is to summarize the available data in the literature about the therapeutic applications of transcranial magnetic stimulation and transcranial direct current stimulation in attention-deficit hyperactivity disorder (ADHD). METHOD: The scientific literature search of international articles was performed in February 2016 using the PubMed electronic database. The following MeSH terms were employed: "attention-deficit disorder with hyperactivity" AND "transcranial magnetic stimulation", "attention-deficit disorder with hyperactivity" AND "transcranial direct current stimulation"...
October 10, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27698365/non-invasive-modulation-of-somatosensory-evoked-potentials-by-the-application-of-static-magnetic-fields-over-the-primary-and-supplementary-motor-cortices
#17
Hikari Kirimoto, Akihiko Asao, Hiroyuki Tamaki, Hideaki Onishi
This study was performed to investigate the possibility of non-invasive modulation of SEPs by the application of transcranial static magnetic field stimulation (tSMS) over the primary motor cortex (M1) and supplementary motor cortex (SMA), and to measure the strength of the NdFeB magnetic field by using a gaussmeter. An NdFeB magnet or a non-magnetic stainless steel cylinder (for sham stimulation) was settled on the scalp over M1 and SMA of 14 subjects for periods of 15 min. SEPs following right median nerve stimulation were recorded before and immediately after, 5 min after, and 10 min after tSMS from sites C3' and F3...
October 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27605037/the-coil-array-method-for-creating-a-dynamic-imaging-volume
#18
Elliot Smith, Fabio Freschi, Maurizio Repetto, Stuart Crozier
PURPOSE: Gradient strength and speed are limited by peripheral nerve stimulation (PNS) thresholds. The coil array method allows the gradient field to be moved across the imaging area. This can help reduce PNS and provide faster imaging for image-guided therapy systems such as the magnetic resonance imaging-guided linear accelerator (MRI-linac). THEORY: The coil array is designed such that many coils produce magnetic fields, which combine to give the desired gradient profile...
September 8, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27574579/current-trends-in-identifying-rapidly-acting-treatments-for-depression
#19
Dawn F Ionescu, George I Papakostas
Traditional antidepressant medications generally take weeks-to-months to achieve effect. However, the breakthrough finding of ketamine's rapidly acting antidepressant properties has inspired a decade-and-a-half of progress towards the identification of treatments that work quickly-within hours-to-days. This paradigm-shift in the discovery of antidepressant therapies has significantly changed the current landscape of antidepressant drug development. Building on this, the current review briefly highlights the recent trends in research towards identifying rapidly-acting antidepressants...
June 2016: Current Behavioral Neuroscience Reports
https://www.readbyqxmd.com/read/27568058/low-intensity-repetitive-magnetic-stimulation-lowers-action-potential-threshold-and-increases-spike-firing-in-layer-5-pyramidal-neurons-in-vitro
#20
Alexander D Tang, Ivan Hong, Laura J Boddington, Andrew R Garrett, Sarah Etherington, John N J Reynolds, Jennifer Rodger
Repetitive transcranial magnetic stimulation (rTMS) has become a popular method of modulating neural plasticity in humans. Clinically, rTMS is delivered at high intensities to modulate neuronal excitability. While the high-intensity magnetic field can be targeted to stimulate specific cortical regions, areas adjacent to the targeted area receive stimulation at a lower intensity and may contribute to the overall plasticity induced by rTMS. We have previously shown that low-intensity rTMS induces molecular and structural plasticity in vivo, but the effects on membrane properties and neural excitability have not been investigated...
October 29, 2016: Neuroscience
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