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Low field magnetic stimulation

L Brandejsky, J-A Micoulaud Franchi, R Lopez, S Bioulac, D Da Fonseca, C Daudet, L Boyer, R Richieri, C Lançon
OBJECTIVES: The aim of this review is to summarize the available data in the literature about the therapeutic applications of transcranial magnetic stimulation and transcranial direct current stimulation in attention-deficit hyperactivity disorder (ADHD). METHOD: The scientific literature search of international articles was performed in February 2016 using the PubMed electronic database. The following MeSH terms were employed: "attention-deficit disorder with hyperactivity" AND "transcranial magnetic stimulation", "attention-deficit disorder with hyperactivity" AND "transcranial direct current stimulation"...
October 10, 2016: L'Encéphale
Hikari Kirimoto, Akihiko Asao, Hiroyuki Tamaki, Hideaki Onishi
This study was performed to investigate the possibility of non-invasive modulation of SEPs by the application of transcranial static magnetic field stimulation (tSMS) over the primary motor cortex (M1) and supplementary motor cortex (SMA), and to measure the strength of the NdFeB magnetic field by using a gaussmeter. An NdFeB magnet or a non-magnetic stainless steel cylinder (for sham stimulation) was settled on the scalp over M1 and SMA of 14 subjects for periods of 15 min. SEPs following right median nerve stimulation were recorded before and immediately after, 5 min after, and 10 min after tSMS from sites C3' and F3...
October 4, 2016: Scientific Reports
Elliot Smith, Fabio Freschi, Maurizio Repetto, Stuart Crozier
PURPOSE: Gradient strength and speed are limited by peripheral nerve stimulation (PNS) thresholds. The coil array method allows the gradient field to be moved across the imaging area. This can help reduce PNS and provide faster imaging for image-guided therapy systems such as the magnetic resonance imaging-guided linear accelerator (MRI-linac). THEORY: The coil array is designed such that many coils produce magnetic fields, which combine to give the desired gradient profile...
September 8, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Dawn F Ionescu, George I Papakostas
Traditional antidepressant medications generally take weeks-to-months to achieve effect. However, the breakthrough finding of ketamine's rapidly acting antidepressant properties has inspired a decade-and-a-half of progress towards the identification of treatments that work quickly-within hours-to-days. This paradigm-shift in the discovery of antidepressant therapies has significantly changed the current landscape of antidepressant drug development. Building on this, the current review briefly highlights the recent trends in research towards identifying rapidly-acting antidepressants...
June 2016: Current Behavioral Neuroscience Reports
Alexander D Tang, Ivan Hong, Laura J Boddington, Andrew R Garrett, Sarah Etherington, John N J Reynolds, Jennifer Rodger
Repetitive transcranial magnetic stimulation (rTMS) has become a popular method of modulating neural plasticity in humans. Clinically, rTMS is delivered at high intensities to modulate neuronal excitability. While the high-intensity magnetic field can be targeted to stimulate specific cortical regions, areas adjacent to the targeted area receive stimulation at a lower intensity and may contribute to the overall plasticity induced by rTMS. We have previously shown that low-intensity rTMS induces molecular and structural plasticity in vivo, but the effects on membrane properties and neural excitability have not been investigated...
October 29, 2016: Neuroscience
Heiko Tzschätzsch, Manh Nguyen Trong, Tobias Scheuermann, Selcan Ipek-Ugay, Thomas Fischer, Michael Schultz, Jürgen Braun, Ingolf Sack
Measurement of shear wave speed of the liver and spleen by elastography is an established diagnostic procedure for the detection of hepatic fibrosis, portal hypertension and esophageal varices. However, current elastography systems are limited by the size and penetration depth of elastographic windows. In this study, 2D time-harmonic elastography is proposed for generating full field-of-view shear wave speed maps in great depth. Two-dimensional time-harmonic elastography uses external harmonic stimulation at multiple frequencies to create compound shear wave speed maps...
November 2016: Ultrasound in Medicine & Biology
J Scott Cordova, Saumya S Gurbani, Jeffrey J Olson, Zhongxing Liang, Lee A D Cooper, Hui-Kuo G Shu, Eduard Schreibmann, Stewart G Neill, Constantinos G Hadjipanayis, Chad A Holder, Hyunsuk Shim
The diagnosis, prognosis, and management of patients with gliomas are largely dictated by the pathological analysis of tissue biopsied from a selected region within the lesion. However, due to the heterogeneous and infiltrative nature of gliomas, identifying the optimal region for biopsy with conventional magnetic resonance imaging (MRI) can be quite difficult. This is especially true for low grade gliomas, which often are non-enhancing tumors. To improve the management of patients with these tumors, the field of neuro-oncology requires an imaging modality that can specifically identify a tumor's most anaplastic/aggressive region(s) for biopsy targeting...
June 2016: Tomography: a Journal for Imaging Research
Marie Louise Hesselberg, Gregers Wegener, Poul Erik Buchholtz
Repetitive Magnetic Stimulation (rTMS) has appeared to be a potential non-invasive antidepressant method, which implies non-convulsive focal stimulation of the brain through a time varying magnetic field. The antidepressant potential of rTMS has been supported by animal studies showing a number of interesting similarities between magnetic stimulation and electroconvulsive stimulation (ECS). Despite these positive results, this method still contains many unknown issues. Importantly, there are fundamental uncertainties concerning the optimal combination of stimulus parameters (frequency, intensity, duration, and number of pulses) to obtain an antidepressant effect...
November 1, 2016: Behavioural Brain Research
Songyun Wang, Xiaoya Zhou, Bing Huang, Zhuo Wang, Liping Zhou, Menglong Wang, Lilei Yu, Hong Jiang
Noninvasive magnetic stimulation has been widely used in autonomic disorders in the past few decades, but few studies has been done in cardiac diseases. Recently, studies showed that low-frequency electromagnetic field (LF-EMF) might suppress atrial fibrillation by mediating the cardiac autonomic nervous system. In the present study, the effect of LF-EMF stimulation of left stellate ganglion (LSG) on LSG neural activity and ventricular arrhythmia has been studied in an acute myocardium infarction canine model...
2016: Scientific Reports
P Anninos, A Adamopoulos, A Kotini, N Tsagas
Magnetoencephalographic (MEG) recordings of 10 multiple sclerosis (MS) patients (2 men, 8 women, mean 41.3±9.5 years, mean disease duration 12.7±7.2 years) were obtained using a whole-head 122 - channel MEG system in a magnetically shielded room of low magnetic noise. Our experimental design was double-blind in order to look for possible effect of external pico - Tesla Transcranial Magnetic Stimulation (pT-TMS). The external pT-TMS was applied on the MS patients with proper field characteristics (magnetic field amplitude: 1-7...
July 2016: Multiple Sclerosis and related Disorders
S M van Belkum, F J Bosker, R Kortekaas, D G M Beersma, R A Schoevers
BACKGROUND: Mood disorders constitute a high burden for both patients and society. Notwithstanding the large arsenal of available treatment options, a considerable group of patients does not remit on current antidepressant treatment. There is an urgent need to develop alternative treatment strategies. Recently, low-strength transcranial pulsed electromagnetic field (tPEMF) stimulation has been purported as a promising strategy for such treatment-resistant depression (TRD). The mode of action of this new technique is however largely unknown...
November 3, 2016: Progress in Neuro-psychopharmacology & Biological Psychiatry
Anna Kościarz-Grzesiok, Karolina Sieroń-Stołtny, Malgarzata Polak, Aleksander Sieroń, Waldemar Karcz
The effect of pulsed magnetic field (PMF) on gravitropic response, endogenous growth and growth in the presence of indole-3-acetic acid (IAA) was studied in coleoptiles of maize (Zea mays L.) seedlings. Medium pH changes, measured simultaneously with growth of coleoptile segments, were also determined. In seedlings grown in the presence of PMF, elongation growth of coleoptiles was inhibited by 16%, while growth of roots and mesocotyls did not depend on PMF. Magnetic field also inhibited (by 36%) the gravitropic response of maize seedlings...
July 22, 2016: General Physiology and Biophysics
Alexander D Tang, Andrea S Lowe, Andrew R Garrett, Robert Woodward, William Bennett, Alison J Canty, Michael I Garry, Mark R Hinder, Jeffery J Summers, Roman Gersner, Alexander Rotenberg, Gary Thickbroom, Joseph Walton, Jennifer Rodger
Rodent models of transcranial magnetic stimulation (TMS) play a crucial role in aiding the understanding of the cellular and molecular mechanisms underlying TMS induced plasticity. Rodent-specific TMS have previously been used to deliver focal stimulation at the cost of stimulus intensity (12 mT). Here we describe two novel TMS coils designed to deliver repetitive TMS (rTMS) at greater stimulation intensities whilst maintaining spatial resolution. Two circular coils (8 mm outer diameter) were constructed with either an air or pure iron-core...
2016: Frontiers in Neural Circuits
Yu Zheng, Yang Gao, Ruijuan Chen, Huiquan Wang, Lei Dong, Junrong Dou
Time-varying electromagnetic fields (EMF) can induce some physiological effects in neuronal tissues, which have been explored in many applications such as transcranial magnetic stimulation. Although transmembrane potentials and induced currents have already been the subjects of many theoretical studies, most previous works about this topic are mainly completed by utilizing Maxwell's equations, often by solving a Laplace equation. In previous studies, cells were often considered to be three-compartment models with different electroconductivities in different regions (three compartments are often intracellular regions, membrane, and extracellular regions)...
October 2016: Bioelectromagnetics
Marisa Cornacchione, Manuela Pellegrini, Lorenzo Fassina, Maria Evelina Mognaschi, Sara Di Siena, Roberto Gimmelli, Paolo Ambrosino, Maria Virginia Soldovieri, Maurizio Taglialatela, Daniele Gianfrilli, Andrea M Isidori, Andrea Lenzi, Fabio Naro
Proper β-adrenergic signaling is indispensable for modulating heart frequency. Studies on extremely-low-frequency pulsed electromagnetic field (ELF-PEMF) effects in the heart beat function are contradictory and no definitive conclusions were obtained so far. To investigate the interplay between ELF-PEMF exposure and β-adrenergic signaling, cultures of primary murine neonatal cardiomyocytes and of sinoatrial node were exposed to ELF-PEMF and short and long-term effects were evaluated. The ELF-PEMF generated a variable magnetic induction field of 0-6mT at a frequency of 75Hz...
September 2016: Journal of Molecular and Cellular Cardiology
Yuranny Cabral-Calderin, Kathleen A Williams, Alexander Opitz, Peter Dechent, Melanie Wilke
Transcranial alternating current stimulation (tACS) is a promising tool for modulating brain oscillations. Combining tACS with functional magnetic resonance imaging (fMRI), we recently showed that tACS applied over the occipital cortex did not exert its strongest effect on regions below the electrodes, but mainly on more distant fronto-parietal regions. Theoretically, this effect could be explained by tACS-induced modulation of functional connectivity between directly stimulated areas and more distant but anatomically and functionally connected regions...
November 1, 2016: NeuroImage
Maysam Z Pedram, Amir Shamloo, Aria Alasty, Ebrahim Ghafar-Zadeh
This paper scrutinizes the magnetic field effect to deliver the superparamagnetic nanoparticles (SPMNs) through the Blood Brain Barrier (BBB). Herein we study the interaction between the nanoparticle (NP) and BBB membrane using Molecular Dynamic (MD) techniques. The MD model is used to enhance our understanding of the dynamic behavior of SPMNs crossing the endothelial cells in the presence of a gradient magnetic field. Actuation of NPs under weak magnetic field offers the great advantage of a non-invasive drug delivery without the risk of causing injury to the brain...
2016: Biosensors
M V Ulitko, S Yu Medvedeva, V V Malakhov
The results of clinical studies give evidence of the beneficial preventive and therapeutic effects of the «Tiline-EM» physiotherapeutic device designed for the combined specific treatment of the skin regions onto which both discomfort and pain sensations are directly projected, reflectively active sites and zones, as well as trigger zones with the use of low-frequency pulsed electric current and magnetic field. The efficient application of the device requires the understanding of the general mechanisms underlying such action on the living systems including those operating at the cellular and subcellular levels...
May 2016: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
Susana de Sousa Araújo, Stefania Paparella, Daniele Dondi, Antonio Bentivoglio, Daniela Carbonera, Alma Balestrazzi
In the context of seed technology, the use of physical methods for increasing plant production offers advantages over conventional treatments based on chemical substances. The effects of physical invigoration treatments in seeds can be now addressed at multiple levels, ranging from morpho-structural aspects to changes in gene expression and protein or metabolite accumulation. Among the physical methods available, "magneto-priming" and irradiation with microwaves (MWs) or ionizing radiations (IRs) are the most promising pre-sowing seed treatments...
2016: Frontiers in Plant Science
Gernot Schmid, Rene Hirtl
The reference levels and maximum permissible exposure values for magnetic fields that are currently used have been derived from basic restrictions under the assumption of upright standing body models in a standard posture, i.e. with arms laterally down and without contact with metallic objects. Moreover, if anatomical modelling of the body was used at all, the skin was represented as a single homogeneous tissue layer. In the present paper we addressed the possible impacts of posture and skin modelling in scenarios of exposure to a 50 Hz uniform magnetic field on the in situ electric field strength in peripheral tissues, which must be limited in order to avoid peripheral nerve stimulation...
June 21, 2016: Physics in Medicine and Biology
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