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Low field magnetic stimulation

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https://www.readbyqxmd.com/read/27893442/inconsistency-of-a-recently-proposed-method-for-assessing-magnetic-field-exposure-for-protection-against-peripheral-nerve-stimulation-in-occupational-situations
#1
Gernot Schmid, Rene Hirtl
A non-binding guide to practical implementation of European Directive 2013/35/EU concerning the limitation of occupational exposure against electromagnetic fields has been published recently. With regard to exposure assessment this guide proposes practically applicable assessment methods for non-uniform and non-sinusoidal environmental electric and magnetic fields, respectively. For non-sinusoidal magnetic fields in the low frequency range this guide proposes a time domain assessment (TDA) method, claimed to reduce the overestimation of exposure inherent to other assessment methods while being based on fundamental physiological principles regarding nerve stimulation...
November 28, 2016: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/27891079/contribution-of-tms-and-rtms-in-the-understanding-of-the-pathophysiology-and-in-the-treatment-of-dystonia
#2
REVIEW
Pierre Lozeron, Aurélia Poujois, Alexandra Richard, Sana Masmoudi, Elodie Meppiel, France Woimant, Nathalie Kubis
Dystonias represent a heterogeneous group of movement disorders responsible for sustained muscle contraction, abnormal postures, and muscle twists. It can affect focal or segmental body parts or be generalized. Primary dystonia is the most common form of dystonia but it can also be secondary to metabolic or structural dysfunction, the consequence of a drug's side-effect or of genetic origin. The pathophysiology is still not elucidated. Based on lesion studies, dystonia has been regarded as a pure motor dysfunction of the basal ganglia loop...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27884774/esponsive-multifunctional-drug-delivery-nanoparticles-for-elastic-matrix-regenerative-repair
#3
Balakrishnan Sivaraman, Ganesh Swaminathan, Lee Moore, Jonathan Fox, Dhruv Seshadri, Shataakshi Dahal, Ivan Stoilov, Maciej Zborowski, Robert Mecham, Anand Ramamurthi
: Arresting or regressing growth of abdominal aortic aneurysms (AAAs), localized expansions of the abdominal aorta are contingent on inhibiting chronically overexpressed matrix metalloproteases (MMPs)-2 and -9 that disrupt elastic matrix within the aortic wall, concurrent with providing a stimulus to augmenting inherently poor auto-regeneration of these matrix structures. In a recent study we demonstrated that localized, controlled and sustained delivery of doxycycline (DOX; a tetracycline-based antibiotic) from poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs), enhances elastic matrix deposition and MMP-inhibition at a fraction of the therapeutically effective oral dose...
November 21, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27875942/a-combined-study-of-meg-and-pico-tesla-tms-on-children-with-autism-disorder
#4
Photios Anninos, Athanasios Chatzimichael, Adam Adamopoulos, Athanasia Kotini, Nicolaos Tsagas
Magnetoencephalographic (MEG) recordings from the brain of 10 children with autism (6 boys and 4 girls, with ages range from 5-12 years, mean[Formula: see text][Formula: see text][Formula: see text]SD: 8.3[Formula: see text][Formula: see text][Formula: see text]2.1) were obtained using a whole-head 122-channel MEG system in a magnetically shielded room of low magnetic noise. A double-blind experimental design was used in order to look for possible effect of external pico-Tesla Transcranial Magnetic Stimulation (pT-TMS)...
November 23, 2016: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/27857683/in-vitro-magnetic-stimulation-a-simple-stimulation-device-to-deliver-defined-low-intensity-electromagnetic-fields
#5
Stephanie Grehl, David Martina, Catherine Goyenvalle, Zhi-De Deng, Jennifer Rodger, Rachel M Sherrard
Non-invasive brain stimulation (NIBS) by electromagnetic fields appears to benefit human neurological and psychiatric conditions, although the optimal stimulation parameters and underlying mechanisms remain unclear. Although, in vitro studies have begun to elucidate cellular mechanisms, stimulation is delivered by a range of coils (from commercially available human stimulation coils to laboratory-built circuits) so that the electromagnetic fields induced within the tissue to produce the reported effects are ill-defined...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27793904/pulsed-electromagnetic-field-with-temozolomide-can-elicit-an-epigenetic-pro-apoptotic-effect-on-glioblastoma-t98g-cells
#6
Francesca Pasi, Lorenzo Fassina, Maria Evelina Mognaschi, Giuseppe Lupo, Franco Corbella, Rosanna Nano, Enrica Capelli
Treatment with pulsed electromagnetic fields (PEMFs) is emerging as an interesting therapeutic option for patients with cancer. The literature has demonstrated that low-frequency/low-energy electromagnetic fields do not cause predictable effects on DNA; however, they can epigenetically act on gene expression. The aim of the present work was to study a possible epigenetic effect of a PEMF, mediated by miRNAs, on a human glioblastoma cell line (T98G). We tested a PEMF (maximum magnetic induction, 2 mT; frequency, 75 Hz) that has been demonstrated to induce autophagy in glioblastoma cells...
November 2016: Anticancer Research
https://www.readbyqxmd.com/read/27774373/miniature-atomic-scalar-magnetometer-for-space-based-on-the-rubidium-isotope-87-rb
#7
Haje Korth, Kim Strohbehn, Francisco Tejada, Andreas G Andreou, John Kitching, Svenja Knappe, S John Lehtonen, Shaughn M London, Matiwos Kafel
A miniature atomic scalar magnetometer based on the rubidium isotope (87)Rb was developed for operation in space. The instrument design implements both Mx and Mz mode operation and leverages a novel microelectromechanical system (MEMS) fabricated vapor cell and a custom silicon-on-sapphire (SOS) complementary metal-oxide-semiconductor (CMOS) integrated circuit. The vapor cell has a volume of only 1 mm(3) so that it can be efficiently heated to its operating temperature by a specially designed, low-magnetic-field-generating resistive heater implemented in multiple metal layers of the transparent sapphire substrate of the SOS-CMOS chips...
August 2016: Journal of Geophysical Research. Space Physics
https://www.readbyqxmd.com/read/27745724/-noninvasive-cerebral-stimulation-for-treatment-of-adhd-a-review-of-the-literature
#8
L Brandejsky, J-A Micoulaud Franchi, R Lopez, S Bioulac, D Da Fonseca, C Daudet, L Boyer, R Richieri, C Lançon
OBJECTIVES: The aim of this review is to summarize the available data in the literature about the therapeutic applications of transcranial magnetic stimulation and transcranial direct current stimulation in attention-deficit hyperactivity disorder (ADHD). METHOD: The scientific literature search of international articles was performed in February 2016 using the PubMed electronic database. The following MeSH terms were employed: "attention-deficit disorder with hyperactivity" AND "transcranial magnetic stimulation", "attention-deficit disorder with hyperactivity" AND "transcranial direct current stimulation"...
October 10, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27698365/non-invasive-modulation-of-somatosensory-evoked-potentials-by-the-application-of-static-magnetic-fields-over-the-primary-and-supplementary-motor-cortices
#9
Hikari Kirimoto, Akihiko Asao, Hiroyuki Tamaki, Hideaki Onishi
This study was performed to investigate the possibility of non-invasive modulation of SEPs by the application of transcranial static magnetic field stimulation (tSMS) over the primary motor cortex (M1) and supplementary motor cortex (SMA), and to measure the strength of the NdFeB magnetic field by using a gaussmeter. An NdFeB magnet or a non-magnetic stainless steel cylinder (for sham stimulation) was settled on the scalp over M1 and SMA of 14 subjects for periods of 15 min. SEPs following right median nerve stimulation were recorded before and immediately after, 5 min after, and 10 min after tSMS from sites C3' and F3...
October 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27605037/the-coil-array-method-for-creating-a-dynamic-imaging-volume
#10
Elliot Smith, Fabio Freschi, Maurizio Repetto, Stuart Crozier
PURPOSE: Gradient strength and speed are limited by peripheral nerve stimulation (PNS) thresholds. The coil array method allows the gradient field to be moved across the imaging area. This can help reduce PNS and provide faster imaging for image-guided therapy systems such as the magnetic resonance imaging-guided linear accelerator (MRI-linac). THEORY: The coil array is designed such that many coils produce magnetic fields, which combine to give the desired gradient profile...
September 8, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27574579/current-trends-in-identifying-rapidly-acting-treatments-for-depression
#11
Dawn F Ionescu, George I Papakostas
Traditional antidepressant medications generally take weeks-to-months to achieve effect. However, the breakthrough finding of ketamine's rapidly acting antidepressant properties has inspired a decade-and-a-half of progress towards the identification of treatments that work quickly-within hours-to-days. This paradigm-shift in the discovery of antidepressant therapies has significantly changed the current landscape of antidepressant drug development. Building on this, the current review briefly highlights the recent trends in research towards identifying rapidly-acting antidepressants...
June 2016: Current Behavioral Neuroscience Reports
https://www.readbyqxmd.com/read/27568058/low-intensity-repetitive-magnetic-stimulation-lowers-action-potential-threshold-and-increases-spike-firing-in-layer-5-pyramidal-neurons-in-vitro
#12
Alexander D Tang, Ivan Hong, Laura J Boddington, Andrew R Garrett, Sarah Etherington, John N J Reynolds, Jennifer Rodger
Repetitive transcranial magnetic stimulation (rTMS) has become a popular method of modulating neural plasticity in humans. Clinically, rTMS is delivered at high intensities to modulate neuronal excitability. While the high-intensity magnetic field can be targeted to stimulate specific cortical regions, areas adjacent to the targeted area receive stimulation at a lower intensity and may contribute to the overall plasticity induced by rTMS. We have previously shown that low-intensity rTMS induces molecular and structural plasticity in vivo, but the effects on membrane properties and neural excitability have not been investigated...
October 29, 2016: Neuroscience
https://www.readbyqxmd.com/read/27567061/two-dimensional-time-harmonic-elastography-of-the-human-liver-and-spleen
#13
Heiko Tzschätzsch, Manh Nguyen Trong, Tobias Scheuermann, Selcan Ipek-Ugay, Thomas Fischer, Michael Schultz, Jürgen Braun, Ingolf Sack
Measurement of shear wave speed of the liver and spleen by elastography is an established diagnostic procedure for the detection of hepatic fibrosis, portal hypertension and esophageal varices. However, current elastography systems are limited by the size and penetration depth of elastographic windows. In this study, 2D time-harmonic elastography is proposed for generating full field-of-view shear wave speed maps in great depth. Two-dimensional time-harmonic elastography uses external harmonic stimulation at multiple frequencies to create compound shear wave speed maps...
November 2016: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27489883/a-systematic-pipeline-for-the-objective-comparison-of-whole-brain-spectroscopic-mri-with-histology-in-biopsy-specimens-from-grade-iii-glioma
#14
J Scott Cordova, Saumya S Gurbani, Jeffrey J Olson, Zhongxing Liang, Lee A D Cooper, Hui-Kuo G Shu, Eduard Schreibmann, Stewart G Neill, Constantinos G Hadjipanayis, Chad A Holder, Hyunsuk Shim
The diagnosis, prognosis, and management of patients with gliomas are largely dictated by the pathological analysis of tissue biopsied from a selected region within the lesion. However, due to the heterogeneous and infiltrative nature of gliomas, identifying the optimal region for biopsy with conventional magnetic resonance imaging (MRI) can be quite difficult. This is especially true for low grade gliomas, which often are non-enhancing tumors. To improve the management of patients with these tumors, the field of neuro-oncology requires an imaging modality that can specifically identify a tumor's most anaplastic/aggressive region(s) for biopsy targeting...
June 2016: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/27473004/antidepressant-efficacy-of-high-and-low-frequency-transcranial-magnetic-stimulation-in-the-fsl-frl-genetic-rat-model-of-depression
#15
Marie Louise Hesselberg, Gregers Wegener, Poul Erik Buchholtz
Repetitive Magnetic Stimulation (rTMS) has appeared to be a potential non-invasive antidepressant method, which implies non-convulsive focal stimulation of the brain through a time varying magnetic field. The antidepressant potential of rTMS has been supported by animal studies showing a number of interesting similarities between magnetic stimulation and electroconvulsive stimulation (ECS). Despite these positive results, this method still contains many unknown issues. Importantly, there are fundamental uncertainties concerning the optimal combination of stimulus parameters (frequency, intensity, duration, and number of pulses) to obtain an antidepressant effect...
November 1, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27470078/noninvasive-low-frequency-electromagnetic-stimulation-of-the-left-stellate-ganglion-reduces-myocardial-infarction-induced-ventricular-arrhythmia
#16
Songyun Wang, Xiaoya Zhou, Bing Huang, Zhuo Wang, Liping Zhou, Menglong Wang, Lilei Yu, Hong Jiang
Noninvasive magnetic stimulation has been widely used in autonomic disorders in the past few decades, but few studies has been done in cardiac diseases. Recently, studies showed that low-frequency electromagnetic field (LF-EMF) might suppress atrial fibrillation by mediating the cardiac autonomic nervous system. In the present study, the effect of LF-EMF stimulation of left stellate ganglion (LSG) on LSG neural activity and ventricular arrhythmia has been studied in an acute myocardium infarction canine model...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27456873/meg-evaluation-of-pico-tesla-external-tms-on-multiple-sclerosis-patients
#17
P Anninos, A Adamopoulos, A Kotini, N Tsagas
Magnetoencephalographic (MEG) recordings of 10 multiple sclerosis (MS) patients (2 men, 8 women, mean 41.3±9.5 years, mean disease duration 12.7±7.2 years) were obtained using a whole-head 122 - channel MEG system in a magnetically shielded room of low magnetic noise. Our experimental design was double-blind in order to look for possible effect of external pico - Tesla Transcranial Magnetic Stimulation (pT-TMS). The external pT-TMS was applied on the MS patients with proper field characteristics (magnetic field amplitude: 1-7...
July 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27449361/treatment-of-depression-with-low-strength-transcranial-pulsed-electromagnetic-fields-a-mechanistic-point-of-view
#18
S M van Belkum, F J Bosker, R Kortekaas, D G M Beersma, R A Schoevers
BACKGROUND: Mood disorders constitute a high burden for both patients and society. Notwithstanding the large arsenal of available treatment options, a considerable group of patients does not remit on current antidepressant treatment. There is an urgent need to develop alternative treatment strategies. Recently, low-strength transcranial pulsed electromagnetic field (tPEMF) stimulation has been purported as a promising strategy for such treatment-resistant depression (TRD). The mode of action of this new technique is however largely unknown...
November 3, 2016: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/27447398/effect-of-low-frequency-pulsed-magnetic-field-on-gravitropic-response-and-cell-elongation-in-coleoptiles-of-maize-seedlings
#19
Anna Kościarz-Grzesiok, Karolina Sieroń-Stołtny, Malgarzata Polak, Aleksander Sieroń, Waldemar Karcz
The effect of pulsed magnetic field (PMF) on gravitropic response, endogenous growth and growth in the presence of indole-3-acetic acid (IAA) was studied in coleoptiles of maize (Zea mays L.) seedlings. Medium pH changes, measured simultaneously with growth of coleoptile segments, were also determined. In seedlings grown in the presence of PMF, elongation growth of coleoptiles was inhibited by 16%, while growth of roots and mesocotyls did not depend on PMF. Magnetic field also inhibited (by 36%) the gravitropic response of maize seedlings...
July 22, 2016: General Physiology and Biophysics
https://www.readbyqxmd.com/read/27445702/construction-and-evaluation-of-rodent-specific-rtms-coils
#20
Alexander D Tang, Andrea S Lowe, Andrew R Garrett, Robert Woodward, William Bennett, Alison J Canty, Michael I Garry, Mark R Hinder, Jeffery J Summers, Roman Gersner, Alexander Rotenberg, Gary Thickbroom, Joseph Walton, Jennifer Rodger
Rodent models of transcranial magnetic stimulation (TMS) play a crucial role in aiding the understanding of the cellular and molecular mechanisms underlying TMS induced plasticity. Rodent-specific TMS have previously been used to deliver focal stimulation at the cost of stimulus intensity (12 mT). Here we describe two novel TMS coils designed to deliver repetitive TMS (rTMS) at greater stimulation intensities whilst maintaining spatial resolution. Two circular coils (8 mm outer diameter) were constructed with either an air or pure iron-core...
2016: Frontiers in Neural Circuits
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