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Low field magnetic stimulation

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https://www.readbyqxmd.com/read/29300001/redesigning-existing-transcranial-magnetic-stimulation-coils-to-reduce-energy-application-to-low-field-magnetic-stimulation
#1
Boshuo Wang, Michael R Shen, Zhi-De Deng, James Evan Smith, Joseph James Tharayil, Clement J Gurrey, Luis J Gomez, Angel V Peterchev
To present a systematic framework and exemplar for the development of a compact and energy-efficient coil that replicates the electric field (E-field) distribution induced by an existing transcranial magnetic stimulation coil. Approach. The E-field generated by a conventional low field magnetic stimulation (LFMS) coil was measured for a spherical head model and simulated in both spherical and realistic head models. Then, using a spherical head model and spatial harmonic decomposition, a spherical-shaped cap coil was synthesized such that its windings conformed to a spherical surface and replicated the E-field on the cortical surface while requiring less energy...
January 4, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29286120/influence-of-static-magnetic-fields-on-human-myoblast-mesenchymal-stem-cell-co%C3%A2-cultures
#2
Cornelia Emika Mueller, Richard Birk, Benedikt Kramer, Angela Wenzel, J Ulrich Sommer, Karl Hörmann, Jens Stern-Straeter, Christian Weilbach
The results of surgical repair of extensive muscle tissue defects are still of primary concern, leaving patients with residual cosmetic and functional impairments. Therefore, skeletal muscle tissue engineering attempts to grow functional neo‑tissue from human stem cells to promote tissue regeneration and support defect closure. Despite intensive research efforts, the goal of stable induction of myogenic differentiation in expanded human stem cells by using clinically feasible stimuli, has not yet been reached to a sufficient extent...
December 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29273346/characterization-of-water-self-diffusion-in-human-stratum-corneum
#3
Chandana Kodiweera, Yuan Yang, Annette L Bunge
The stratum corneum (SC) is the outermost layer of human skin and primary barrier to water loss and chemical exposure. It consists of keratin-filled corneocytes of large aspect ratio surrounded by a thin matrix of highly organized lipophilic molecules. In the presence of water, the corneocytes swell and permeability for many chemicals increases. The role of hydration and SC structure on water self-diffusion was investigated using the pulsed-gradient stimulated echo (PGSTE) nuclear magnetic resonance (NMR) technique...
December 19, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29258808/incomplete-evidence-that-increasing-current-intensity-of-tdcs-boosts-outcomes
#4
Zeinab Esmaeilpour, Paola Marangolo, Benjamin M Hampstead, Sven Bestmann, Elisabeth Galletta, Helena Knotkova, Marom Bikson
BACKGROUND: Transcranial direct current stimulation (tDCS) is investigated to modulate neuronal function by applying a fixed low-intensity direct current to scalp. OBJECTIVES: We critically discuss evidence for a monotonic response in effect size with increasing current intensity, with a specific focus on a question if increasing applied current enhance the efficacy of tDCS. METHODS: We analyzed tDCS intensity does-response from different perspectives including biophysical modeling, animal modeling, human neurophysiology, neuroimaging and behavioral/clinical measures...
December 13, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29210178/acute-exposure-to-high-induction-electromagnetic-field-affects-activity-of-model-peripheral-sensory-neurons
#5
Jaroslav Prucha, Jan Krusek, Ivan Dittert, Viktor Sinica, Anna Kadkova, Viktorie Vlachova
Exposure to repetitive low-frequency electromagnetic field (LF-EMF) shows promise as a non-invasive approach to treat various sensory and neurological disorders. Despite considerable progress in the development of modern stimulation devices, there is a limited understanding of the mechanisms underlying their biological effects and potential targets at the cellular level. A significant impact of electromagnetic field on voltage-gated calcium channels and downstream signalling pathways has been convincingly demonstrated in many distinct cell types...
December 6, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29160793/a-gal-m%C3%A2%C2%B5s-device-to-evaluate-cell-migratory-response-to-combined-galvano-chemotactic-fields
#6
Shawn Mishra, Maribel Vazquez
Electric fields have been studied extensively in biomedical engineering (BME) for numerous regenerative therapies. Recent studies have begun to examine the biological effects of electric fields in combination with other environmental cues, such as tissue-engineered extracellular matrices (ECM), chemical gradient profiles, and time-dependent temperature gradients. In the nervous system, cell migration driven by electrical fields, or galvanotaxis, has been most recently studied in transcranial direct stimulation (TCDS), spinal cord repair and tumor treating fields (TTF)...
November 21, 2017: Biosensors
https://www.readbyqxmd.com/read/29150051/glutamate-is-down-regulated-and-tinnitus-loudness-levels-decreased-following-rtms-over-auditory-cortex-of-the-left-hemisphere-a-prospective-randomized-single-blinded-sham-controlled-cross-over-study
#7
Anthony T Cacace, Jiani Hu, Stephen Romero, Yang Xuan, Robert F Burkard, Richard S Tyler
Using a prospective randomized single-blinded sham-controlled cross-over design, we studied the efficacy of low frequency (1-Hz) repetitive transcranial magnetic stimulation (rTMS) over auditory cortex of the left temporal lobe as an experimental treatment modality for noise-induced tinnitus. Pre/post outcome measures for sham vs. active rTMS conditions included differential changes in tinnitus loudness, self-perceived changes in the Tinnitus Handicap Questionnaire (THQ), and neurochemical changes of brain metabolite concentrations using single voxel proton magnetic resonance spectroscopy ((1)H-MRS) obtained from left and right auditory cortical areas...
November 14, 2017: Hearing Research
https://www.readbyqxmd.com/read/29124106/gamma-rhythm-low-field-magnetic-stimulation-alleviates-neuropathologic-changes-and-rescues-memory-and-cognitive-impairments-in-a-mouse-model-of-alzheimer-s-disease
#8
Junli Zhen, Yanjing Qian, Xiechuan Weng, Wenting Su, Jianliang Zhang, Lihui Cai, Lin Dong, Haiting An, Ruijun Su, Jiang Wang, Yan Zheng, Xiaomin Wang
Introduction: The abnormal amyloid β (Aβ) accumulation and Aβ-related neural network dysfunction are considered central to the pathogenesis of Alzheimer's disease (AD) at the early stage. Deep-brain reachable low field magnetic stimulation (DMS), a novel noninvasive approach that was designed to intervene the network activity in brains, has been found to alleviate stress-related cognitive impairments. Methods: Amyloid precursor protein/presenilin-1 transgenic mice (5XFAD) were treated with DMS, and cognitive behavior and AD-like pathologic changes in the neurochemical and electrophysiological properties in 5XFAD mice were assessed...
November 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29119962/-the-specific-features-of-the-development-of-metabolic-and-regenerative-processes-under-the-action-of-low-intensity-electromagnetic-radiation-in-radiation-exposure-conditions-an-experimental-study
#9
Yu N Korolev, L V Mihajlik, L A Nikulina, M S Geniatulina
The experiments on male white rats with the use of biochemical, photo-optical, and electron-microscopic techniques have demonstrated that the use of low-intensity electromagnetic radiation of ultrahigh frequency (EMR UHF) and low-intensity low-frequency magnetic field (MF) during the post-irradiation period (within 21 days after exposure to radiation) enhanced the metabolic and regenerative processes in the testes and liver. It was shown that the application of MF largely intensified the antioxidant activity whereas EMR UHF preferentially stimulated the biosynthetic processes as well as the processes of cellular and intracellular regeneration...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29109357/occupational-exposure-to-electromagnetic-fields-from-medical-sources
#10
Rianne Stam, Sachiko Yamaguchi-Sekino
High exposures to electromagnetic fields (EMF) can occur near certain medical devices in the hospital environment. A systematic assessment of medical occupational EMF exposure could help to clarify where more attention to occupational safety may be needed. This paper seeks to identify sources of high exposure for hospital workers and compare the published exposure data to occupational limits in the European Union. A systematic search for peer-reviewed publications was conducted via PubMed and Scopus databases...
November 3, 2017: Industrial Health
https://www.readbyqxmd.com/read/29092489/influence-of-the-on-line-elf-emf-stimulation-on-the-electrophysiological-properties-of-the-rat-hippocampal-ca1-neurons-in-vitro
#11
Yu Zheng, Wei Ma, Lei Dong, Jun-Rong Dou, Yang Gao, Jing Xue
The extremely low frequency electromagnetic fields (ELF-EMFs) have been shown to have an environmentally negative effect on humans' health; however, its treatment effect is beneficial for patients suffering from neurological disorders. Despite this success, the application of ELF-EMF has exceeded in the understanding of its internal mechanism. Recently, it was found that on-line magnetic stimulation may offer advantages over off-line magnetic exposure and has proven to be effective in activating the prefrontal cortex pyramidal neurons in vitro...
October 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29060150/electric-field-characteristics-of-low-field-synchronized-transcranial-magnetic-stimulation-stms
#12
Zhi-De Deng, Sarah H Lisanby
Low-field synchronized trancranial magnetic stimulation (sTMS) was hypothesized to have significant therapeutic effects in patients with major depressive disorder by entrainment of neural oscillations. The sTMS device is comprised of neodymium magnets mounted over multiple brain regions and set to rotate at the patients alpha frequency. We characterized the electric field strength and distribution of sTMS using the finite element method. We found that the maximum induced electric field strength on the surfaces of the head and cortex are approximately 0...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29052337/magnetic-stimulus-responsive-vancomycin-drug-delivery-system-based-on-chitosan-microbeads-embedded-with-magnetic-nanoparticles
#13
Ankita Mohapatra, Michael A Harris, David LeVine, Madhav Ghimire, Jessica A Jennings, Bashir I Morshed, Warren O Haggard, Joel D Bumgardner, Sanjay R Mishra, Tomoko Fujiwara
Local antibiotic delivery can overcome some of the shortcomings of systemic therapy, such as low local concentrations and delivery to avascular sites. A localized drug delivery system (DDS), ideally, could also use external stimuli to modulate the normal drug release profile from the DDS to provide efficacious drug administration and flexibility to healthcare providers. To achieve this objective, chitosan microbeads embedded with magnetic nanoparticles were loaded with the antibiotic vancomycin and stimulated by a high frequency alternating magnetic field...
October 20, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29039021/fifty-hertz-magnetic-field-affects-the-epigenetic-modulation-of-the-mir-34b-c-in-neuronal-cells
#14
Claudia Consales, Claudia Cirotti, Giuseppe Filomeni, Martina Panatta, Alessio Butera, Caterina Merla, Vanni Lopresto, Rosanna Pinto, Carmela Marino, Barbara Benassi
The exposure to extremely low-frequency magnetic fields (ELF-MFs) has been associated to increased risk of neurodegenerative diseases, although the underlying molecular mechanisms are still undefined. Since epigenetic modulation has been recently encountered among the key events leading to neuronal degeneration, we here aimed at assessing if the control of gene expression mediated by miRNAs, namely miRs-34, has any roles in driving neuronal cell response to 50-Hz (1 mT) magnetic field in vitro. We demonstrate that ELF-MFs drive an early reduction of the expression level of miR-34b and miR-34c in SH-SY5Y human neuroblastoma cells, as well as in mouse primary cortical neurons, by affecting the transcription of the common pri-miR-34...
October 16, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29035881/activation-of-signaling-cascades-by-weak-extremely-low-frequency-electromagnetic-fields
#15
Einat Kapri-Pardes, Tamar Hanoch, Galia Maik-Rachline, Manuel Murbach, Patricia L Bounds, Niels Kuster, Rony Seger
BACKGROUND/AIMS: Results from recent studies suggest that extremely low frequency magnetic fields (ELF-MF) interfere with intracellular signaling pathways related to proliferative control. The mitogen-activated protein kinases (MAPKs), central signaling components that regulate essentially all stimulated cellular processes, include the extracellular signal-regulated kinases 1/2 (ERK1/2) that are extremely sensitive to extracellular cues. Anti-phospho-ERK antibodies serve as a readout for ERK1/2 activation and are able to detect minute changes in ERK stimulation...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29030111/double-blind-proof-of-concept-poc-trial-of-low-field-magnetic-stimulation-lfms-augmentation-of-antidepressant-therapy-in-treatment-resistant-depression-trd
#16
Maurizio Fava, Marlene P Freeman, Martina Flynn, Bettina B Hoeppner, Richard Shelton, Dan V Iosifescu, James W Murrough, David Mischoulon, Cristina Cusin, Mark Rapaport, Boadie W Dunlop, Madhukar H Trivedi, Manish Jha, Gerard Sanacora, Gretchen Hermes, George I Papakostas
BACKGROUND: Low-Field Magnetic Stimulation (LFMS) is a novel, non-invasive, sub-threshold neuromodulation technique, shown in preliminary studies to have immediate mood elevating effects in both unipolar and bipolar depressed patients. OBJECTIVE: We aimed to assess the antidepressant augmentation effects at 48 h of LFMS administered on two consecutive days compared to sham treatment in treatment resistant depression (TRD) subjects, using the Sequential Parallel Comparison Design (SPCD)...
September 23, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29021752/potential-impact-of-geomagnetic-field-in-transcranial-magnetic-stimulation-for-the-treatment-of-neurodegenerative-diseases
#17
Kwon-Seok Chae, Yong-Hwan Kim
Throughout the long history of various therapeutic trials of transcranial magnetic stimulation (TMS), some TMS protocols have been reported to be clearly effective in the treatment of neurodegenerative diseases. Despite promising results from repetitive TMS (rTMS) using low frequency electromagnetic fields (EMFs) for neurodegenerative diseases, the low reproducibility has hampered the clinical applications of rTMS. Here, based on the notion of radical pair mechanism explaining magnetoreception in living organisms, we propose a new perspective that rTMS with controlled geomagnetic field (rTMS-GMF) can be an efficient and reproducible therapeutic approach for neurodegenerative diseases...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29020806/transcranial-static-magnetic-field-stimulation-tsms-of-the-visual-cortex-decreases-experimental-photophobia
#18
Elena Lozano-Soto, Vanesa Soto-León, Simona Sabbarese, Lara Ruiz-Alvarez, Margarita Sanchez-Del-Rio, Juan Aguilar, Bryan A Strange, Guglielmo Foffani, Antonio Oliviero
Background Transcranial static magnetic field stimulation (tSMS) reduces cortical excitability in humans. Methods The objective of this study was to determine whether tSMS over the occipital cortex is effective in reducing experimental photophobia. In a sham-controlled double-blind crossover study, tSMS (or sham) was applied for 10 minutes with a cylindrical magnet on the occiput of 20 healthy subjects. We assessed subjective discomfort induced by low-intensity and high-intensity visual stimuli presented in a dark room before, during and after tSMS (or sham)...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28939890/an-open-label-one-arm-dose-escalation-study-to-evaluate-safety-and-tolerability-of-extremely-low-frequency-magnetic-fields-in-acute-ischemic-stroke
#19
Fioravante Capone, Micaela Liberti, Francesca Apollonio, Francesca Camera, Stefania Setti, Ruggero Cadossi, Carlo Cosimo Quattrocchi, Vincenzo Di Lazzaro
Extremely low frequency magnetic fields (ELF-MF) could be an alternative neuroprotective approach for ischemic stroke because preclinical studies have demonstrated their effects on the mechanisms underlying ischemic damage. The purpose of this open-label, one arm, dose-escalation, exploratory study is to evaluate the safety and tolerability of ELF-MF in patients with acute ischemic stroke. Within 48 hours from the stroke onset, patients started ELF-MF treatment, daily for 5 consecutive days. Clinical follow-up lasted 12 months...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28910407/the-spectral-features-of-eeg-responses-to-transcranial-magnetic-stimulation-of-the-primary-motor-cortex-depend-on-the-amplitude-of-the-motor-evoked-potentials
#20
Matteo Fecchio, Andrea Pigorini, Angela Comanducci, Simone Sarasso, Silvia Casarotto, Isabella Premoli, Chiara-Camilla Derchi, Alice Mazza, Simone Russo, Federico Resta, Fabio Ferrarelli, Maurizio Mariotti, Ulf Ziemann, Marcello Massimini, Mario Rosanova
Transcranial magnetic stimulation (TMS) of the primary motor cortex (M1) can excite both cortico-cortical and cortico-spinal axons resulting in TMS-evoked potentials (TEPs) and motor-evoked potentials (MEPs), respectively. Despite this remarkable difference with other cortical areas, the influence of motor output and its amplitude on TEPs is largely unknown. Here we studied TEPs resulting from M1 stimulation and assessed whether their waveform and spectral features depend on the MEP amplitude. To this aim, we performed two separate experiments...
2017: PloS One
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