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Low field magnetic stimulation

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https://www.readbyqxmd.com/read/29124106/gamma-rhythm-low-field-magnetic-stimulation-alleviates-neuropathologic-changes-and-rescues-memory-and-cognitive-impairments-in-a-mouse-model-of-alzheimer-s-disease
#1
Junli Zhen, Yanjing Qian, Xiechuan Weng, Wenting Su, Jianliang Zhang, Lihui Cai, Lin Dong, Haiting An, Ruijun Su, Jiang Wang, Yan Zheng, Xiaomin Wang
Introduction: The abnormal amyloid β (Aβ) accumulation and Aβ-related neural network dysfunction are considered central to the pathogenesis of Alzheimer's disease (AD) at the early stage. Deep-brain reachable low field magnetic stimulation (DMS), a novel noninvasive approach that was designed to intervene the network activity in brains, has been found to alleviate stress-related cognitive impairments. Methods: Amyloid precursor protein/presenilin-1 transgenic mice (5XFAD) were treated with DMS, and cognitive behavior and AD-like pathologic changes in the neurochemical and electrophysiological properties in 5XFAD mice were assessed...
November 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29119962/-the-specific-features-of-the-development-of-metabolic-and-regenerative-processes-under-the-action-of-low-intensity-electromagnetic-radiation-in-radiation-exposure-conditions-an-experimental-study
#2
Yu N Korolev, L V Mihajlik, L A Nikulina, M S Geniatulina
The experiments on male white rats with the use of biochemical, photo-optical, and electron-microscopic techniques have demonstrated that the use of low-intensity electromagnetic radiation of ultrahigh frequency (EMR UHF) and low-intensity low-frequency magnetic field (MF) during the post-irradiation period (within 21 days after exposure to radiation) enhanced the metabolic and regenerative processes in the testes and liver. It was shown that the application of MF largely intensified the antioxidant activity whereas EMR UHF preferentially stimulated the biosynthetic processes as well as the processes of cellular and intracellular regeneration...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29109357/occupational-exposure-to-electromagnetic-fields-from-medical-sources
#3
Rianne Stam, Sachiko Yamaguchi-Sekino
High exposures to electromagnetic fields (EMF) can occur near certain medical devices in the hospital environment. A systematic assessment of medical occupational EMF exposure could help to clarify where more attention to occupational safety may be needed. This paper seeks to identify sources of high exposure for hospital workers and compare the published exposure data to occupational limits in the European Union. A systematic search for peer-reviewed publications was conducted via PubMed and Scopus databases...
November 3, 2017: Industrial Health
https://www.readbyqxmd.com/read/29092489/influence-of-the-on-line-elf-emf-stimulation-on-the-electrophysiological-properties-of-the-rat-hippocampal-ca1-neurons-in-vitro
#4
Yu Zheng, Wei Ma, Lei Dong, Jun-Rong Dou, Yang Gao, Jing Xue
The extremely low frequency electromagnetic fields (ELF-EMFs) have been shown to have an environmentally negative effect on humans' health; however, its treatment effect is beneficial for patients suffering from neurological disorders. Despite this success, the application of ELF-EMF has exceeded in the understanding of its internal mechanism. Recently, it was found that on-line magnetic stimulation may offer advantages over off-line magnetic exposure and has proven to be effective in activating the prefrontal cortex pyramidal neurons in vitro...
October 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29060150/electric-field-characteristics-of-low-field-synchronized-transcranial-magnetic-stimulation-stms
#5
Zhi-De Deng, Sarah H Lisanby
Low-field synchronized trancranial magnetic stimulation (sTMS) was hypothesized to have significant therapeutic effects in patients with major depressive disorder by entrainment of neural oscillations. The sTMS device is comprised of neodymium magnets mounted over multiple brain regions and set to rotate at the patients alpha frequency. We characterized the electric field strength and distribution of sTMS using the finite element method. We found that the maximum induced electric field strength on the surfaces of the head and cortex are approximately 0...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29052337/magnetic-stimulus-responsive-vancomycin-drug-delivery-system-based-on-chitosan-microbeads-embedded-with-magnetic-nanoparticles
#6
Ankita Mohapatra, Michael A Harris, David LeVine, Madhav Ghimire, Jessica A Jennings, Bashir I Morshed, Warren O Haggard, Joel D Bumgardner, Sanjay R Mishra, Tomoko Fujiwara
Local antibiotic delivery can overcome some of the shortcomings of systemic therapy, such as low local concentrations and delivery to avascular sites. A localized drug delivery system (DDS), ideally, could also use external stimuli to modulate the normal drug release profile from the DDS to provide efficacious drug administration and flexibility to healthcare providers. To achieve this objective, chitosan microbeads embedded with magnetic nanoparticles were loaded with the antibiotic vancomycin and stimulated by a high frequency alternating magnetic field...
October 20, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29039021/fifty-hertz-magnetic-field-affects-the-epigenetic-modulation-of-the-mir-34b-c-in-neuronal-cells
#7
Claudia Consales, Claudia Cirotti, Giuseppe Filomeni, Martina Panatta, Alessio Butera, Caterina Merla, Vanni Lopresto, Rosanna Pinto, Carmela Marino, Barbara Benassi
The exposure to extremely low-frequency magnetic fields (ELF-MFs) has been associated to increased risk of neurodegenerative diseases, although the underlying molecular mechanisms are still undefined. Since epigenetic modulation has been recently encountered among the key events leading to neuronal degeneration, we here aimed at assessing if the control of gene expression mediated by miRNAs, namely miRs-34, has any roles in driving neuronal cell response to 50-Hz (1 mT) magnetic field in vitro. We demonstrate that ELF-MFs drive an early reduction of the expression level of miR-34b and miR-34c in SH-SY5Y human neuroblastoma cells, as well as in mouse primary cortical neurons, by affecting the transcription of the common pri-miR-34...
October 16, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29035881/activation-of-signaling-cascades-by-weak-extremely-low-frequency-electromagnetic-fields
#8
Einat Kapri-Pardes, Tamar Hanoch, Galia Maik-Rachline, Manuel Murbach, Patricia L Bounds, Niels Kuster, Rony Seger
BACKGROUND/AIMS: Results from recent studies suggest that extremely low frequency magnetic fields (ELF-MF) interfere with intracellular signaling pathways related to proliferative control. The mitogen-activated protein kinases (MAPKs), central signaling components that regulate essentially all stimulated cellular processes, include the extracellular signal-regulated kinases 1/2 (ERK1/2) that are extremely sensitive to extracellular cues. Anti-phospho-ERK antibodies serve as a readout for ERK1/2 activation and are able to detect minute changes in ERK stimulation...
October 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29030111/double-blind-proof-of-concept-poc-trial-of-low-field-magnetic-stimulation-lfms-augmentation-of-antidepressant-therapy-in-treatment-resistant-depression-trd
#9
Maurizio Fava, Marlene P Freeman, Martina Flynn, Bettina B Hoeppner, Richard Shelton, Dan V Iosifescu, James W Murrough, David Mischoulon, Cristina Cusin, Mark Rapaport, Boadie W Dunlop, Madhukar H Trivedi, Manish Jha, Gerard Sanacora, Gretchen Hermes, George I Papakostas
BACKGROUND: Low-Field Magnetic Stimulation (LFMS) is a novel, non-invasive, sub-threshold neuromodulation technique, shown in preliminary studies to have immediate mood elevating effects in both unipolar and bipolar depressed patients. OBJECTIVE: We aimed to assess the antidepressant augmentation effects at 48 h of LFMS administered on two consecutive days compared to sham treatment in treatment resistant depression (TRD) subjects, using the Sequential Parallel Comparison Design (SPCD)...
September 23, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29021752/potential-impact-of-geomagnetic-field-in-transcranial-magnetic-stimulation-for-the-treatment-of-neurodegenerative-diseases
#10
Kwon-Seok Chae, Yong-Hwan Kim
Throughout the long history of various therapeutic trials of transcranial magnetic stimulation (TMS), some TMS protocols have been reported to be clearly effective in the treatment of neurodegenerative diseases. Despite promising results from repetitive TMS (rTMS) using low frequency electromagnetic fields (EMFs) for neurodegenerative diseases, the low reproducibility has hampered the clinical applications of rTMS. Here, based on the notion of radical pair mechanism explaining magnetoreception in living organisms, we propose a new perspective that rTMS with controlled geomagnetic field (rTMS-GMF) can be an efficient and reproducible therapeutic approach for neurodegenerative diseases...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29020806/transcranial-static-magnetic-field-stimulation-tsms-of-the-visual-cortex-decreases-experimental-photophobia
#11
Elena Lozano-Soto, Vanesa Soto-León, Simona Sabbarese, Lara Ruiz-Alvarez, Margarita Sanchez-Del-Rio, Juan Aguilar, Bryan A Strange, Guglielmo Foffani, Antonio Oliviero
Background Transcranial static magnetic field stimulation (tSMS) reduces cortical excitability in humans. Methods The objective of this study was to determine whether tSMS over the occipital cortex is effective in reducing experimental photophobia. In a sham-controlled double-blind crossover study, tSMS (or sham) was applied for 10 minutes with a cylindrical magnet on the occiput of 20 healthy subjects. We assessed subjective discomfort induced by low-intensity and high-intensity visual stimuli presented in a dark room before, during and after tSMS (or sham)...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28939890/an-open-label-one-arm-dose-escalation-study-to-evaluate-safety-and-tolerability-of-extremely-low-frequency-magnetic-fields-in-acute-ischemic-stroke
#12
Fioravante Capone, Micaela Liberti, Francesca Apollonio, Francesca Camera, Stefania Setti, Ruggero Cadossi, Carlo Cosimo Quattrocchi, Vincenzo Di Lazzaro
Extremely low frequency magnetic fields (ELF-MF) could be an alternative neuroprotective approach for ischemic stroke because preclinical studies have demonstrated their effects on the mechanisms underlying ischemic damage. The purpose of this open-label, one arm, dose-escalation, exploratory study is to evaluate the safety and tolerability of ELF-MF in patients with acute ischemic stroke. Within 48 hours from the stroke onset, patients started ELF-MF treatment, daily for 5 consecutive days. Clinical follow-up lasted 12 months...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28910407/the-spectral-features-of-eeg-responses-to-transcranial-magnetic-stimulation-of-the-primary-motor-cortex-depend-on-the-amplitude-of-the-motor-evoked-potentials
#13
Matteo Fecchio, Andrea Pigorini, Angela Comanducci, Simone Sarasso, Silvia Casarotto, Isabella Premoli, Chiara-Camilla Derchi, Alice Mazza, Simone Russo, Federico Resta, Fabio Ferrarelli, Maurizio Mariotti, Ulf Ziemann, Marcello Massimini, Mario Rosanova
Transcranial magnetic stimulation (TMS) of the primary motor cortex (M1) can excite both cortico-cortical and cortico-spinal axons resulting in TMS-evoked potentials (TEPs) and motor-evoked potentials (MEPs), respectively. Despite this remarkable difference with other cortical areas, the influence of motor output and its amplitude on TEPs is largely unknown. Here we studied TEPs resulting from M1 stimulation and assessed whether their waveform and spectral features depend on the MEP amplitude. To this aim, we performed two separate experiments...
2017: PloS One
https://www.readbyqxmd.com/read/28887547/uncovering-the-effect-of-low-frequency-static-magnetic-field-on-tendon-derived-cells-from-mechanosensing-to-tenogenesis
#14
Tamagno Pesqueira, Raquel Costa-Almeida, Manuela E Gomes
Magnetotherapy has been receiving increased attention as an attractive strategy for modulating cell physiology directly at the site of injury, thereby providing the medical community with a safe and non-invasive therapy. Yet, how magnetic field influences tendon cells both at the cellular and molecular levels remains unclear. Thus, the influence of a low-frequency static magnetic field (2 Hz, 350 mT) on human tendon-derived cells was studied using different exposure times (4 and 8 h; short-term studies) and different regimens of exposure to an 8h-period of magnetic stimulation (continuous, every 24 h or every 48 h; long-term studies)...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28875707/remote-manipulation-of-ligand-nano-oscillations-regulates-adhesion-and-polarization-of-macrophages-in-vivo
#15
Heemin Kang, Sungkyu Kim, Dexter Siu Hong Wong, Hee Joon Jung, Sien Lin, Kaijie Zou, Rui Li, Gang Li, Vinayak P Dravid, Liming Bian
Macrophages play crucial roles in various immune-related responses, such as host defense, wound healing, disease progression, and tissue regeneration. Macrophages perform distinct and dynamic functions in vivo, depending on their polarization states, such as the pro-inflammatory M1 phenotype and pro-healing M2 phenotype. Remote manipulation of the adhesion of host macrophages to the implants and their subsequent polarization in vivo can be an attractive strategy to control macrophage polarization-specific functions but has rarely been achieved...
October 11, 2017: Nano Letters
https://www.readbyqxmd.com/read/28868887/controllable-preparation-of-cufemno4-nanospheres-as-a-novel-multifunctional-affinity-probe-for-efficient-adsorption-and-selective-enrichment-of-low-abundance-peptides-and-phosphopeptides
#16
Xing-Yu Long, Zi-Jin Zhang, Jia-Yuan Li, Dong Sheng, Hong-Zhen Lian
A facile solvothermal method for the synthesis of multifunctional magnetic CuFeMnO4 nanospheres affinity probe (NSAP) with controllable morphology and size was developed for the first time. The CuFeMnO4 nanospheres combine the brilliant features of Cu(2+), Fe(3+), and Mn(2+) ions, so their multifunction performances are embodied by strong coordination to carboxyl and amine groups of peptides (Cu(2+) and Fe(3+)), special affinity to phosphate groups of phosphopeptides (Fe(3+) and Mn(2+)), and high magnetic responsiveness in a magnetic field...
September 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28842627/enhancement-of-mesenchymal-stem-cell-chondrogenesis-with-short-term-low-intensity-pulsed-electromagnetic-fields
#17
Dinesh Parate, Alfredo Franco-Obregón, Jürg Fröhlich, Christian Beyer, Azlina A Abbas, Tunku Kamarul, James H P Hui, Zheng Yang
Pulse electromagnetic fields (PEMFs) have been shown to recruit calcium-signaling cascades common to chondrogenesis. Here we document the effects of specified PEMF parameters over mesenchymal stem cells (MSC) chondrogenic differentiation. MSCs undergoing chondrogenesis are preferentially responsive to an electromagnetic efficacy window defined by field amplitude, duration and frequency of exposure. Contrary to conventional practice of administering prolonged and repetitive exposures to PEMFs, optimal chondrogenic outcome is achieved in response to brief (10 minutes), low intensity (2 mT) exposure to 6 ms bursts of magnetic pulses, at 15 Hz, administered only once at the onset of chondrogenic induction...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28831658/magnetic-treatment-of-microalgae-for-enhanced-product-formation
#18
REVIEW
Lucielen Oliveira Santos, Kricelle Mosquera Deamici, Bruno Costa Menestrino, Jaqueline Garda-Buffon, Jorge Alberto Vieira Costa
Static or modulated magnetic fields (MF) may interact with the biological system and affect the metabolism of microorganisms, such as their photosynthetic capacity or synthesis of carbohydrates. Their effects on microorganisms, which can be classified into inhibiting, stimulating and null, may be interpreted as the result of stress that cells undergo, thus, leading to responses through the same mechanisms. Biological effects of exposure to magnetic forces depend on magnetic intensity, frequency and exposure time...
August 22, 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28780826/-influence-of-extremely-low-frequency-magnetic-field-on-circadian-rhythm-of-cryptochrome-in-mouse-embryonic-fibroblasts
#19
Z Y Sun, D Y Geng, C F Chen, P P Wang, T Song
Objective: To investigate the influence of extremely low-frequency magnetic field on periodical expression of cryptochrome (Cry) gene in mouse embryonic fibroblast NIH3T3 cells. Methods: The NIH3T3 cells were divided into magnetic field group and sham-exposure group. The NIH3T3 cells in the magnetic field group were stimulated by horse serum and then exposed to an extremely low-frequency magnetic field (50 Hz and 0.3 mT) for 48 hours, and those in the sham-exposure group were also stimulated by horse serum and then exposed to a coil for 48 hours...
June 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28755870/use-of-near-infrared-spectroscopy-in-the-investigation-of-brain-activation-during-cognitive-aging-a-systematic-review-of-an-emerging-area-of-research
#20
REVIEW
Nounagnon F Agbangla, Michel Audiffren, Cédric T Albinet
The cognitive neuroscience of aging is a growing and stimulating research area. The development of neuroimaging techniques in the past two decades has considerably increased our understanding of the brain mechanisms that might underlie cognitive performance and resulting changes due to normal aging. Beside traditional metabolic neuroimaging techniques, such as Positron Emission Tomography and functional Magnetic Resonance Imaging, near infrared spectroscopy (NIRS), an optical imaging technique allowing to monitor real-time cerebral blood oxygenation, has gained recent interest in this field...
September 2017: Ageing Research Reviews
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