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Low field magnetic stimulation

N I Schastnaya, V S Ulashchyk
BACKGROUND: in spite of the fact that photomagnetic therapy with the use of the FotoSPOK device (Magnomed Ltd., Belarus) is already used in the medical practice, the application of this method for the management of many diseases remains to be substantiated on the scientifically sound grounds. AIM: The objective of the present study was to evaluate the effectiveness of photomagnetic therapy in the treatment of the local inflammatory process in the skin and to elaborate the rationale for the application of this technique in the treatment of contact dermatitis...
May 21, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
Jingjing Jiang, Xinyi Lin, Dong Ding, Guowang Diao
Taking advantages of the toehold-triggered strand displacement reaction (TSDR) and host-guest interaction of β-cyclodextrin (β-CD), a facile enzyme-free and homogeneous electrochemical sensing strategy was designed for the sensitive assay of target DNA using Fe3 O4 @SiO2 @β-CD nanocomposites and ferrocene-labeled hairpin DNA (H-1) as the capture and electrochemical probes, respectively. Upon addition of target molecule, the initiated TSDR process induced the conformational change of H-1, and subsequently stimulated the dynamic assembly of assist probes (A-1 and A-2) to generate H-1:A-1:A-2 duplex along with the release of target sequence...
April 17, 2018: Biosensors & Bioelectronics
Mun Bae Lee, Hyung Joong Kim, Eung Je Woo, Oh In Kwon
Transcranial direct current stimulation (tDCS) is a widely used non-invasive brain stimulation technique by applying low-frequency weak direct current via electrodes attached on the head. The tDCS using a fixed current between 1 and 2 mA has relied on computational modelings to achieve optimal stimulation effects. Recently, by measuring the tDCS current induced magnetic field using an MRI scanner, the internal current pathway has been successfully recovered. However, up to now, there is no technique to visualize electrical properties including the electrical anisotropic conductivity, effective extracellular ion-concentration, and electric field using only the tDCS current in-vivo...
2018: PloS One
P A Robinson, J C Pagès, N C Gabay, T Babaie, K N Mukta
Neural field theory is used to predict and analyze the phenomenon of perceptual echo in which random input stimuli at one location are correlated with electroencephalographic responses at other locations. It is shown that this echo correlation (EC) yields an estimate of the transfer function from the stimulated point to other locations. Modal analysis then explains the observed spatiotemporal structure of visually driven EC and the dominance of the alpha frequency; two eigenmodes of similar amplitude dominate the response, leading to temporal beating and a line of low correlation that runs from the crown of the head toward the ears...
April 2018: Physical Review. E
Athanasia Kostopoulou, Konstantinos Brintakis, Eirini Fragogeorgi, Amalia Anthousi, Liberato Manna, Sylvie Begin-Colin, Claire Billotey, Anthi Ranella, George Loudos, Irene Athanassakis, Alexandros Lappas
Advances in surfactant-assisted chemical approaches have led the way for the exploitation of nanoscale inorganic particles in medical diagnosis and treatment. In this field, magnetically-driven multimodal nanotools that perform both detection and therapy, well-designed in size, shape and composition, are highly advantageous. Such a theranostic material—which entails the controlled assembly of smaller (maghemite) nanocrystals in a secondary motif that is highly dispersible in aqueous media—is discussed here...
May 9, 2018: Nanomaterials
Andrey M Tokmachev, Dmitry V Averyanov, Oleg E Parfenov, Alexander N Taldenkov, Igor A Karateev, Ivan S Sokolov, Oleg A Kondratev, Vyacheslav G Storchak
The appeal of ultra-compact spintronics drives intense research on magnetism in low-dimensional materials. Recent years have witnessed remarkable progress in engineering two-dimensional (2D) magnetism via defects, edges, adatoms, and magnetic proximity. However, intrinsic 2D ferromagnetism remained elusive until recent discovery of out-of-plane magneto-optical response in Cr-based layers, stimulating the search for 2D magnets with tunable and diverse properties. Here we employ a bottom-up approach to produce layered structures of silicene (a Si counterpart of graphene) functionalized by rare-earth atoms, ranging from the bulk down to one monolayer...
April 26, 2018: Nature Communications
Atsushi Saito, Masayuki Takahashi, Kei Makino, Yukihisa Suzuki, Yasuhiko Jimbo, Satoshi Nakasono
High-intensity and low frequency (1-100 kHz) time-varying electromagnetic fields stimulate the human body through excitation of the nervous system. In power frequency range (50/60 Hz), a frequency-dependent threshold of the external electric field-induced neuronal modulation in cultured neuronal networks was used as one of the biological indicator in international guidelines; however, the threshold of the magnetic field-induced neuronal modulation has not been elucidated. In this study, we exposed rat brain-derived neuronal networks to a high-intensity power frequency magnetic field (hPF-MF), and evaluated the modulation of synchronized bursting activity using a multi-electrode array (MEA)-based extracellular recording technique...
2018: Frontiers in Physiology
Y N Korolev, I P Bobrovnitskii, M S Geniatulina, L A Nikulina, L V Mikhailik
BACKGROUND: it has been demonstrated in various experimental studies that radiation exposure produces a negative impact on the processes of spermatogenesis associated with the disturbances of the microcirculation processes in the testes and the development of cellular and intracellular disintegration expressed as destructive changes in the cells leading to their death. AIM: The objective of the present study was to detect the ultrastructural abnormalities in the cells of Sertoli and spermatogonia under conditions of their exposure to radiation and to identify the peculiarities of their regeneration under the influence of the therapeutic and prophylactic application of low-intensity ultra-high frequency (UHF) electromagnetic radiation (EMR) and low-intensity low-frequency magnetic field (MF)...
April 9, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
Kalina Makowiecki, Andrew Garrett, Alan R Harvey, Jennifer Rodger
Repetitive transcranial stimulation (rTMS) is an increasingly popular method to non-invasively modulate cortical excitability in research and clinical settings. During rTMS, low-intensity magnetic fields reach areas perifocal to the target brain region, however, effects of these low-intensity (LI-) fields and how they interact with ongoing neural activity remains poorly defined. We evaluated whether coordinated neural activity during electromagnetic stimulation alters LI-rTMS effects on cortical excitability by comparing visually evoked potentials (VEP) and densities of parvalbumin-expressing (PV+) GABAergic interneurons in adult mouse visual cortex after LI-rTMS under different conditions: LI-rTMS applied during visually evoked (strong, coordinated) activity or in darkness (weak, spontaneous activity)...
April 11, 2018: Scientific Reports
Muzhaozi Yuan, Ya Wang, Yi-Xian Qin
Neuroregeneration imposes a significant challenge in neuroscience for treating neurodegenerative diseases. The objective of this study is to evaluate the hypothesis that the nerve growth factor (NGF) functionalized superparamagnetic iron oxide (SPIO)-gold (Au) nanomedicine can stimulate the neuron growth and differentiation under external magnetic fields (MFs), and dynamic MFs outperform their static counterparts. The SPIO-Au core-shell nanoparticles (NPs) (Diameter: 20.8 nm) possessed advantages such as uniform quasi-spherical shapes, narrow size distribution, excellent stabilities, and low toxicity (viability >96% for 5-day)...
April 5, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Jakub Taradaj, Marcin Ozon, Robert Dymarek, Bartosz Bolach, Karolina Walewicz, Joanna Rosińczuk
BACKGROUND: Interdisciplinary physical therapy together with pharmacological treatment constitute conservative treatment strategies related to low back pain (LBP). There is still a lack of high quality studies aimed at an objective evaluation of physiotherapeutic procedures according to their effectiveness in LBP. OBJECTIVES: The aim of this study is to carry out a prospective, randomized, single-blinded, and placebocontrolled clinical trial to evaluate the effectiveness of magnetic fields in discopathy-related LBP...
March 23, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Thérèse Barbier, Sarra Aissani, Nicolas Weber, Cédric Pasquier, Jacques Felblinger
PURPOSE: To evaluate the function of an active implantable medical device (AIMD) during magnetic resonance imaging (MRI) scans. The induced voltages caused by the switching of magnetic field gradients and rectified radio frequency (RF) pulse were measured, along with the AIMD stimulations. MATERIALS AND METHODS: An MRI-compatible voltage probe with a bandwidth of 0-40 kHz was designed. Measurements were carried out both on the bench with an overvoltage protection circuit commonly used for AIMD and with a pacemaker during MRI scans on a 1...
March 30, 2018: Magma
Pervez Hoodbhoy
In a two dimensional free electron gas (2DEG) subjected to a perpendicular spatially varying magnetic field the classical paths of electrons are snake-like trajectories that weave along the line where the field crosses zero. But quantum mechanically this system is described by a symmetric double well potential which, for low excitations, leads to very different electron behavior. We compute the spectrum, as well as the wavefunctions, for states of definite parity in the limit of nearly degenerate states, i...
March 26, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Ivan Hong, Andrew Garrett, Garth Maker, Ian Mullaney, Jennifer Rodger, Sarah J Etherington
Low intensity repetitive magnetic stimulation of neural tissue modulates neuronal excitability and has promising therapeutic potential in the treatment of neurological disorders. However, the underpinning cellular and biochemical mechanisms remain poorly understood. This study investigates the behavioural effects of low intensity repetitive magnetic stimulation (LI-rMS) at a cellular and biochemical level. We delivered LI-rMS (10 mT) at 1 Hz and 10 Hz to B50 rat neuroblastoma cells in vitro for 10 minutes and measured levels of selected metabolites immediately after stimulation...
2018: PeerJ
Chalathan Saengruengrit, Patcharee Ritprajak, Supason Wanichwecharungruang, Apoorva Sharma, Georgeta Salvan, Dietrich R T Zahn, Numpon Insin
Superparamagnetic iron oxide nanoparticles (SPIONs) have received much attention in drug and biomolecule delivery systems. Here, we report a delivery system using the combination of a magnetic field and the relatively biocompatible composite particles of poly(lactic-co-glycolic acid) and SPIONs (SPION-PLGA particles) for protein delivery to bone-marrow derived primary dendritic cells (BM-DCs). SPIONs with the diameter of ∼10 nm were synthesized via thermal decomposition of iron(III) oleate. The SPIONs and bovine serum albumin (BSA) were encapsulated in PLGA particles of two different diameters, 300 and 500 nm...
June 15, 2018: Journal of Colloid and Interface Science
Jesper D Nielsen, Kristoffer H Madsen, Oula Puonti, Hartwig R Siebner, Christian Bauer, Camilla Gøbel Madsen, Guilherme B Saturnino, Axel Thielscher
Anatomically realistic volume conductor models of the human head are important for accurate forward modeling of the electric field during transcranial brain stimulation (TBS), electro- (EEG) and magnetoencephalography (MEG). In particular, the skull compartment exerts a strong influence on the field distribution due to its low conductivity, suggesting the need to represent its geometry accurately. However, automatic skull reconstruction from structural magnetic resonance (MR) images is difficult, as compact bone has a very low signal in magnetic resonance imaging (MRI)...
July 1, 2018: NeuroImage
Michele Dileone, Laura Mordillo-Mateos, Antonio Oliviero, Guglielmo Foffani
BACKGROUND: Transcranial static magnetic field stimulation (tSMS) was recently added to the family of inhibitory non-invasive brain stimulation techniques. However, the application of tSMS for 10-20 min over the motor cortex (M1) induces only short-lasting effects that revert within few minutes. OBJECTIVE: We examined whether increasing the duration of tSMS to 30 min leads to long-lasting changes in cortical excitability, which is critical for translating tSMS toward clinical applications...
February 7, 2018: Brain Stimulation
K Spyridopoulou, A Makridis, N Maniotis, N Karypidou, E Myrovali, T Samaras, M Angelakeris, K Chlichlia, O Kalogirou
Recent investigations have attempted to understand and exploit the impact of magnetic field-actuated internalized magnetic nanoparticles (MNPs) on the proliferation rate of cancer cells. Due to the complexity of the parameters governing magnetic field-exposure though, individual studies to date have raised contradictory results. In our approach we performed a comparative analysis of key parameters related to the cell exposure of cancer cells to magnetic field-actuated MNPs, and to the magnetic field, in order to better understand the factors affecting cellular responses to magnetic field-stimulated MNPs...
April 27, 2018: Nanotechnology
Anne Sauvaget, Samuel Bulteau, Alice Guilleux, Juliette Leboucher, Anne Pichot, Pierre Valrivière, Jean-Marie Vanelle, Véronique Sébille-Rivain, Marie Grall-Bronnec
Background Craving is a core symptom of addictive disorders, such as pathological gambling for example. Over the last decade, several studies have assessed the efficacy of repetitive transcranial magnetic stimulation (rTMS) in the addiction field, which triggers the dorsolateral prefrontal cortex (DLPFC) to decrease craving. The STIMJEU study investigated whether a single session of low-frequency (LF, i.e., 1 Hz) rTMS applied to the right DLPFC reduced cue-induced gambling craving in a sample of treatment-seeking pathological gamblers...
March 1, 2018: Journal of Behavioral Addictions
Le Xiao, Christoph U Correll, Lei Feng, Yu-Tao Xiang, Yuan Feng, Chang-Qing Hu, Rena Li, Gang Wang
BACKGROUND: Low-field magnetic stimulation (LFMS) has mood-elevating effect, and the increase of brain-derived neurotrophic factor (BDNF) is associated with antidepressant treatment. We evaluated the effects and association with BDNF of rhythmic LFMS in the treatment of major depressive disorder (MDD). METHODS: A total of 22 MDD patients were randomized to rhythmic alpha stimulation (RAS) or rhythmic delta stimulation (RDS), with 5 sessions per week, lasting for 6 weeks...
February 20, 2018: CNS Spectrums
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