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https://www.readbyqxmd.com/read/28925806/population-pharmacokinetics-of-arginine-glutamate-in-healthy-chinese-volunteers
#1
Jing Wang, Heng Zheng, Kun Wang, Zheng Wang, Yufeng Ding
1. The present study developed population pharmacokinetic models of arginine and glutamate in healthy Chinese volunteers. Two nonlinear mixed-effect models were developed using NONMEM® software (ICON Development Solutions, Ellicott City, MD) to describe the pharmacokinetic properties and to assess the relevant parameters as well as the inter-individual variability. The potential covariates were screened using stepwise approach and the stability and predictive capability of the models were performed using bootstrap and visual predictive check...
September 19, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28922795/a-lady-in-proper-proportions-feminism-lytton-strachey-and-florence-nightingale-s-reputation-1918-39
#2
James Southern
Lytton Strachey's Eminent Victorians has long been regarded as a watershed in attitudes to Victorian culture, widely seen as having instigated a revolutionary backlash against the values and heroes of the Victorian era in England. Its impact, however, on the reputations of his four subjects-Thomas Arnold, General Gordon, Cardinal Manning and Florence Nightingale-has been subjected to surprisingly little scholarly attention. Drawing on the work of gender historians, this article reassesses Strachey's effect on the reputation of Nightingale, using biographies and contemporary reviews of Eminent Victorians...
March 1, 2017: 20 Century British History
https://www.readbyqxmd.com/read/28919547/deep-sequencing-to-resolve-complex-diversity-of-apicomplexan-parasites-in-platypuses-and-echidnas-proof-of-principle-for-wildlife-disease-investigation
#3
Jan Šlapeta, Stefan Saverimuttu, Larry Vogelnest, Cheryl Sangster, Frances Hulst, Karrie Rose, Paul Thompson, Richard Whittington
The short-beaked echidna (Tachyglossus aculeatus) and the platypus (Ornithorhynchus anatinus) are iconic egg-laying monotremes (Mammalia: Monotremata) from Australasia. The aim of this study was to demonstrate the utility of diversity profiles in disease investigations of monotremes. Using small subunit (18S) rDNA amplicon deep-sequencing we demonstrated the presence of apicomplexan parasites and confirmed by direct and cloned amplicon gene sequencing Theileria ornithorhynchi, Theileria tachyglossi, Eimeria echidnae and Cryptosporidium fayeri...
September 12, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28917250/emerging-technologies-in-stereotactic-body-radiotherapy
#4
Lijun Ma, Lei Wang, Chia-Lin Tseng, Arjun Sahgal
Stereotactic body radiation therapy (SBRT) stems from the initial developments of intra-cranial stereotactic radiosurgery (SRS). Despite similarity in their names and clinical goals of delivering a sufficiently high tumoricidal dose, maximal sparing of the surrounding normal tissues and a short treatment course, SBRT technologies have transformed from the early days of body frame-based treatments with X-ray verification to primarily image-guided procedures with cone-beam CT or stereoscopic X-ray systems and non-rigid body immo-bilization...
September 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28917125/what-makes-a-face-photo-a-good-likeness
#5
Kay L Ritchie, Robin S S Kramer, A Mike Burton
Photographs of people are commonly said to be 'good likenesses' or 'poor likenesses', and this is a concept that we readily understand. Despite this, there has been no systematic investigation of what makes an image a good likeness, or of which cognitive processes are involved in making such a judgement. In three experiments, we investigate likeness judgements for different types of images: natural images of film stars (Experiment 1), images of film stars from specific films (Experiment 2), and iconic images and face averages (Experiment 3)...
September 13, 2017: Cognition
https://www.readbyqxmd.com/read/28916988/gesture-and-action-exemplar-grace-video-database-stimuli-for-research-on-manners-of-human-locomotion-and-iconic-gestures
#6
Suzanne Aussems, Natasha Kwok, Sotaro Kita
Human locomotion is a fundamental class of events, and manners of locomotion (e.g., how the limbs are used to achieve a change of location) are commonly encoded in language and gesture. To our knowledge, there is no openly accessible database containing normed human locomotion stimuli. Therefore, we introduce the GestuRe and ACtion Exemplar (GRACE) video database, which contains 676 videos of actors performing novel manners of human locomotion (i.e., moving from one location to another in an unusual manner) and videos of a female actor producing iconic gestures that represent these actions...
September 15, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28913870/mimicry-in-butterflies-co-option-and-a-bag-of-magnificent-developmental-genetic-tricks
#7
REVIEW
Riddhi Deshmukh, Saurav Baral, A Gandhimathi, Muktai Kuwalekar, Krushnamegh Kunte
Butterfly wing patterns are key adaptations that are controlled by remarkable developmental and genetic mechanisms that facilitate rapid evolutionary change. With swift advancements in the fields of genomics and genetic manipulations, identifying the regulators of wing development and mimetic wing patterns has become feasible even in nonmodel organisms such as butterflies. Recent mapping and gene expression studies have identified single switch loci of major effects such as transcription factors and supergenes as the main drivers of adaptive evolution of mimetic and polymorphic butterfly wing patterns...
September 14, 2017: Wiley Interdisciplinary Reviews. Developmental Biology
https://www.readbyqxmd.com/read/28912691/the-brain-of-the-black-diceros-bicornis-and-white-ceratotherium-simum-african-rhinoceroses-morphology-and-volumetrics-from-magnetic-resonance-imaging
#8
Adhil Bhagwandin, Mark Haagensen, Paul R Manger
The morphology and volumetrics of the understudied brains of two iconic large terrestrial African mammals: the black (Diceros bicornis) and white (Ceratotherium simum) rhinoceroses are described. The black rhinoceros is typically solitary whereas the white rhinoceros is social, and both are members of the Perissodactyl order. Here, we provide descriptions of the surface of the brain of each rhinoceros. For both species, we use magnetic resonance images (MRI) to develop a description of the internal anatomy of the rhinoceros brain and to calculate the volume of the amygdala, cerebellum, corpus callosum, hippocampus, and ventricular system as well as to determine the gyrencephalic index...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28906188/analysis-of-the-omaha-system-prototype-icons-for-health-literacy-a-global-survey
#9
Yu Jin Kang, Karen A Monsen, Barbara E Martinson, Annika E Stromme, Elizabeth G Weirich, Ryan N Schneider, Emily C Lawrence, Taylor A Maki, Chikako Seebold, Karen S Martin
No abstract text is available yet for this article.
October 2017: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/28893423/-incisions-and-baseline-operative-technique-of-cervicofacial-lifting
#10
F Boucher, S Guerid, E Delay
Cervicofacial lifting is one of the most iconic procedure of plastic surgery and is about hundred years old. In the following chapters of this report, numerous technical points will be specify. A baseline reliable and reproducible technique, appealing to the largest possible audience is presented in order to begin this surgery in optimum conditions. Pre- and postoperative management is also exposed. The aim of this chapter is to precise incisions and baseline operative technique of cervicofacial lifting, with description of SMAS and platysma suspensions as well as complementary procedures like liposuccion and lipofilling...
September 8, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/28882211/introduction-to-northeast-pacific-shark-biology-ecology-and-conservation
#11
Dayv Lowry, Shawn E Larson
Sharks are iconic, sometimes apex, predators found in every ocean and, as a result, they have featured prominently in the mythology, history, and fisheries of diverse human cultures around the world. Because of their regional significance to fisheries and ecological role as predators, and as a result of concern over long-term stability of their populations, there has been an increasing amount of work focused on shark conservation in recent decades. This volume highlights the biodiversity and biological attributes of, and conservation efforts targeted at, populations of sharks that reside in the Northeast Pacific Ocean bordering the west coast of the United States and Canada, one of the most economically and ecologically important oceanic regions in the world...
2017: Advances in Marine Biology
https://www.readbyqxmd.com/read/28878966/assessment-and-analysis-of-human-laterality-for-manipulation-and-communication-using-the-rennes-laterality-questionnaire
#12
Jacques Prieur, Stéphanie Barbu, Catherine Blois-Heulin
Despite significant scientific advances, the nature of the left-hemispheric systems involved in language (speech and gesture) and manual actions is still unclear. To date, investigations of human laterality focused mainly on non-communication functions. Although gestural laterality data have been published for infants and children, relatively little is known about laterality of human gestural communication. This study investigated human laterality in depth considering non-communication manipulation actions and various gesture types involving hands, feet, face and ears...
August 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28877284/caries-progression-in-non-cavitated-fissures-after-infiltrant-application-a-3-year-follow-up-of-a-randomized-controlled-clinical-trial
#13
Camillo Anauate-Netto, Laurindo Borelli, Ricardo Amore, Vinicius DI Hipólito, Paulo Henrique Perlatti D'Alpino
Objectives: To evaluate the efficacy of a conservative treatment to prevent the progression of caries using an infiltrant on non-cavitated pit and fissures. Material and Methods: This controlled clinical trial selected 23 volunteers with clinically and radiographically non-cavitated occlusal caries among patients presenting a "rather low" to "very high" caries risk. Eighty-six teeth were randomly divided into two experimental groups: teeth receiving a commercial pit-and-fissure sealant (Alpha Seal-DFL) and contralateral teeth receiving Icon infiltrant (DMG)...
July 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28873963/de-novo-genome-assembly-and-annotation-of-australia-s-largest-freshwater-fish-the-murray-cod-maccullochella-peelii-from-illumina-and-nanopore-sequencing-read
#14
Christopher M Austin, Mun Hua Tan, Katherine A Harrisson, Yin Peng Lee, Laurence J Croft, Paul Sunnucks, Alexandra Pavlova, Han Ming Gan
One of the most iconic Australian fish is the Murray cod, Maccullochella peelii (Mitchell 1838), a freshwater species that can grow to ∼1.8 metres in length and live to age ≥48 years. The Murray cod is of a conservation concern as a result of strong population contractions, but it is also popular for recreational fishing and is of growing aquaculture interest. In this study, we report the whole genome sequence of the Murray cod to support ongoing population genetics, conservation, and management research, as well as to better understand the evolutionary ecology and history of the species...
August 1, 2017: GigaScience
https://www.readbyqxmd.com/read/28872982/amelogenesis-imperfecta-a-non-invasive-approach-to-improve-esthetics-in-young-patients-report-of-two-cases
#15
Maria Grazia Cagetti, Stefano Cattaneo, Ye Qing Hu, Guglielmo Campus
Objective-Evaluate esthetic and functional efficacy of infiltrant resin (Icon, DMG, Hamburg, Germany) in Amelogenesis Imperfecta's treatment. STUDY DESIGN: Two adolescent patients, G.S. (13 years old) and C.M. (15 years old), affected by the hypomaturation type of Amelogenesis Imperfecta, were treated with Icon resin and were followed for twelve months. RESULTS: Treated teeth show an excellent aesthetical result immediately after the resin application, effect that lasts in the long-term (six and twelve months follow-up examinations); the dental wear's progression seems to be clinically arrested...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28870497/parasites-lost-neglecting-a-crucial-element-in-de-extinction
#16
Christian Selbach, Philip J Seddon, Robert Poulin
Bringing back iconic and beloved extinct species is a hot and intensely debated current topic. Yet, the parasites of de-extinction candidate species have remained largely overlooked in this debate. Here we point out the potentially far-reaching ecological impacts of bringing back extinct species without their parasites.
September 1, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28858796/synergistic-instance-level-subspace-alignment-for-fine-grained-sketch-based-image-retrieval
#17
Ke Li, Kaiyue Pang, Yi-Zhe Song, Timothy M Hospedales, Tao Xiang, Honggang Zhang
We study the problem of fine-grained sketch-based image retrieval. By performing instance-level (rather than category-level) retrieval, it embodies a timely and practical application, particularly with the ubiquitous availability of touchscreens. Three factors contribute to the challenging nature of the problem: (i) free-hand sketches are inherently abstract and iconic, making visual comparisons with photos difficult, (ii) sketches and photos are in two different visual domains, i.e. black and white lines vs...
August 25, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28840520/five-mechanisms-of-sound-symbolic-association
#18
David M Sidhu, Penny M Pexman
Sound symbolism refers to an association between phonemes and stimuli containing particular perceptual and/or semantic elements (e.g., objects of a certain size or shape). Some of the best-known examples include the mil/mal effect (Sapir, Journal of Experimental Psychology, 12, 225-239, 1929) and the maluma/takete effect (Köhler, 1929). Interest in this topic has been on the rise within psychology, and studies have demonstrated that sound symbolic effects are relevant for many facets of cognition, including language, action, memory, and categorization...
August 24, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28839147/bone-histology-sheds-new-light-on-the-ecology-of-the-dodo-raphus-cucullatus-aves-columbiformes
#19
D Angst, A Chinsamy, L Steel, J P Hume
The dodo, Raphus cucullatus, a flightless pigeon endemic to Mauritius, became extinct during the 17(th) century due to anthropogenic activities. Although it was contemporaneous with humans for almost a century, little was recorded about its ecology. Here we present new aspects of the life history of the dodo based on our analysis of its bone histology. We propose that the dodo bred around August and that the rapid growth of the chicks enabled them to reach a robust size before the austral summer or cyclone season...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28833876/females-drive-asymmetrical-introgression-from-rare-to-common-species-in-darwin-s-tree-finches
#20
Katharina J Peters, Steven A Myers, Rachael Y Dudaniec, Jody A O'Connor, Sonia Kleindorfer
The consequences of hybridization for biodiversity depend on the specific ecological and evolutionary context in which it occurs. Understanding patterns of gene flow among hybridizing species is crucial for determining the evolutionary trajectories of species assemblages. The recently discovered hybridization between two species of Darwin's tree finches (Camarhynchus parvulus and C. pauper) on Floreana Island, Galápagos, presents an exciting opportunity to investigate the mechanisms causing hybridization and its potential evolutionary consequences under conditions of recent habitat disturbance and the introduction of invasive pathogens...
August 22, 2017: Journal of Evolutionary Biology
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