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https://www.readbyqxmd.com/read/29775201/tacrolimus-population-pharmacokinetics-and-multiple-cyp3a5-genotypes-in-black-and-white-renal-transplant-recipients
#1
Olivia Campagne, Donald E Mager, Daniel Brazeau, Rocco C Venuto, Kathleen M Tornatore
Tacrolimus exhibits inter-patient pharmacokinetic variability attributed to CYP3A5 isoenzymes and the efflux transporter, P-glycoprotein. Most black renal transplant recipients require higher tacrolimus doses compared to whites to achieve similar troughs when race-adjusted recommendations are used. An established guideline provides tacrolimus genotype dosing recommendations based on CYP3A5*1(W/T) and loss of protein function variants: CYP3A5*3 (rs776746), CYP3A5*6 (rs10264272), CYP3A5*7 (rs41303343) and may provide more comprehensive race-adjusted dosing recommendations...
May 18, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29773769/weathering-us-cuba-political-storms-jos%C3%A3-rubiera-phd-cuba-s-chief-weather-forecaster
#2
Gail Reed
Full disclosure: chief weather forecaster is not his official title, but rather one affectionally conferred on Dr Rubiera by the Cuban people, who look to him not only in times of peril, but also to learn about the science of meteorology. Anyone who has taken a taxi in Cuba during hurricane season (June 1 to November 30), and bothered to ask the driver, will receive a clear explanation about how hurricanes are formed, what the Saffir-Simpson scale is all about, and how the season is shaping up-all courtesy of Dr Rubiera's talent for communication during nightly weather forecasts and special broadcasts...
April 2018: MEDICC Review
https://www.readbyqxmd.com/read/29772875/measuring-high-density-built-environment-for-public-health-research-uncertainty-with-respect-to-data-indicator-design-and-spatial-scale
#3
Guibo Sun, Chris Webster, Michael Y Ni, Xiaohu Zhang
Uncertainty with respect to built environment (BE) data collection, measure conceptualization and spatial scales is evident in urban health research, but most findings are from relatively lowdensity contexts. We selected Hong Kong, an iconic high-density city, as the study area as limited research has been conducted on uncertainty in such areas. We used geocoded home addresses (n=5732) from a large population-based cohort in Hong Kong to extract BE measures for the participants' place of residence based on an internationally recognized BE framework...
May 7, 2018: Geospatial Health
https://www.readbyqxmd.com/read/29772044/a-phase-1-open-label-dose-escalation-trial-to-investigate-safety-and-tolerability-of-single-intravitreous-injections-of-icon-1-targeting-tissue-factor-in-wet-amd
#4
John A Wells, Christine R Gonzales, Brian B Berger, Victor H Gonzalez, Brian D Sippy, Gabriela Burian
BACKGROUND AND OBJECTIVE: This phase 1 study evaluated the safety and tolerability of single intravitreous injections (IVIs) of ICON-1 (Iconic Therapeutics, South San Francisco, CA) in patients with neovascular age-related macular degeneration (nAMD). ICON-1 is a modified factor VIIa protein linked with the Fc portion of a human immunoglobulin G1. The molecule binds tissue factor overexpressed on choroidal neovascularization (CNV) in AMD. PATIENTS AND METHODS: Open-label, interventional, dose-escalation trial in 18 patients with CNV due to AMD, with six patients per dose cohort...
May 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29767792/how-face-blurring-affects-body-language-processing-of-static-gestures-in-women-and-men
#5
A M Proverbio, L Ornaghi, V Gabaro
The role of facial coding in body language comprehension was investigated by ERP recordings in 31 participants viewing 800 photographs of gestures (iconic, deictic and emblematic), which could be congruent or incongruent with their caption. Facial information was obscured by blurring in half of the stimuli. The task consisted of evaluating picture/caption congruence. Quicker response times were observed in women than in men to congruent stimuli, and a cost for incongruent vs. congruent stimuli was found only in men...
May 14, 2018: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29761651/mr%C3%AF-inside-the-meat-pie
#6
John Massie, Michael Kean, Tim Cain
Meat pies have been adopted as one of Australia's favourite foods, and considered an icon by many. The hand-held convenience of the pie has made them a culinary necessity while watching sport, also beloved in Australia. An enduring question about the meat pie is what exactly is inside. This can be difficult to ascertain by digital, ocular or oral exploration. In this study we use MR imaging to study the contents of some of Australia's best loved pies.
May 14, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29761059/biodiversity-of-the-great-barrier-reef-how-adequately-is-it-protected
#7
Zoe T Richards, Jon C Day
Background: The Great Barrier Reef (GBR) is the world's most iconic coral reef ecosystem, recognised internationally as a World Heritage Area of outstanding significance. Safeguarding the biodiversity of this universally important reef is a core legislative objective; however, ongoing cumulative impacts including widespread coral bleaching and other detrimental impacts have heightened conservation concerns for the future of the GBR. Methods: Here we review the literature to report on processes threatening species on the GBR, the status of marine biodiversity, and evaluate the extent of species-level monitoring and reporting...
2018: PeerJ
https://www.readbyqxmd.com/read/29752729/conservation-lessons-from-large-mammal-manipulations-in-east-african-savannas-the-klee-uhuru-and-glade-experiments
#8
REVIEW
Jacob R Goheen, David J Augustine, Kari E Veblen, Duncan M Kimuyu, Todd M Palmer, Lauren M Porensky, Robert M Pringle, Jayashree Ratnam, Corinna Riginos, Mahesh Sankaran, Adam T Ford, Abdikadir A Hassan, Rhiannon Jakopak, Tyler R Kartzinel, Samson Kurukura, Allison M Louthan, Wilfred O Odadi, Tobias O Otieno, Alois M Wambua, Hillary S Young, Truman P Young
African savannas support an iconic fauna, but they are undergoing large-scale population declines and extinctions of large (>5 kg) mammals. Long-term, controlled, replicated experiments that explore the consequences of this defaunation (and its replacement with livestock) are rare. The Mpala Research Centre in Laikipia County, Kenya, hosts three such experiments, spanning two adjacent ecosystems and environmental gradients within them: the Kenya Long-Term Exclosure Experiment (KLEE; since 1995), the Glade Legacies and Defaunation Experiment (GLADE; since 1999), and the Ungulate Herbivory Under Rainfall Uncertainty experiment (UHURU; since 2008)...
May 11, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29740479/a-new-single-nucleotide-polymorphism-database-for-rainbow-trout-generated-through-whole-genome-resequencing
#9
Guangtu Gao, Torfinn Nome, Devon E Pearse, Thomas Moen, Kerry A Naish, Gary H Thorgaard, Sigbjørn Lien, Yniv Palti
Single-nucleotide polymorphisms (SNPs) are highly abundant markers, which are broadly distributed in animal genomes. For rainbow trout ( Oncorhynchus mykiss ), SNP discovery has been previously done through sequencing of restriction-site associated DNA (RAD) libraries, reduced representation libraries (RRL) and RNA sequencing. Recently we have performed high coverage whole genome resequencing with 61 unrelated samples, representing a wide range of rainbow trout and steelhead populations, with 49 new samples added to 12 aquaculture samples from AquaGen (Norway) that we previously used for SNP discovery...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29738723/tropical-savannas-and-dry-forests
#10
R Toby Pennington, Caroline E R Lehmann, Lucy M Rowland
In the tropics, research, conservation and public attention focus on rain forests, but this neglects that half of the global tropics have a seasonally dry climate. These regions are home to dry forests and savannas (Figures 1 and 2), and are the focus of this Primer. The attention given to rain forests is understandable. Their high species diversity, sheer stature and luxuriance thrill biologists today as much as they did the first explorers in the Age of Discovery. Although dry forest and savanna may make less of a first impression, they support a fascinating diversity of plant strategies to cope with stress and disturbance including fire, drought and herbivory...
May 7, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29732713/risk-factors-and-biomarkers-for-the-occurrence-of-uveitis-in-jia-data-from-the-inception-cohort-of-newly-diagnosed-patients-with-juvenile-idiopathic-arthritis-icon-jia-study
#11
Christoph Tappeiner, Jens Klotsche, Claudia Sengler, Martina Niewerth, Ina Liedmann, Karoline Walscheid, Miha Lavric, Dirk Foell, Kirsten Minden, Arnd Heiligenhaus
PURPOSE: To analyze the prognostic value of demographic, clinical, and therapeutic factors and laboratory biomarkers, and to assess their role in predicting uveitis occurrence in patients with JIA. METHODS: Patients with JIA were enrolled within the first year after JIA diagnosis. Demographic and clinical parameters were documented. Serum samples were collected at study enrollment, at 3-month follow-up visits within the first year, and then 6-monthly. A multivariable Cox regression analysis was performed to evaluate the impact of demographic, clinical, laboratory, and therapeutic parameters on uveitis onset...
May 6, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29720414/isolation-by-environment-in-the-highly-mobile-olive-ridley-turtle-lepidochelys-olivacea-in-the-eastern-pacific
#12
Clara J Rodríguez-Zárate, Jonathan Sandoval-Castillo, Erik van Sebille, Robert G Keane, Axayácatl Rocha-Olivares, Jose Urteaga, Luciano B Beheregaray
Spatial and temporal scales at which processes modulate genetic diversity over the landscape are usually overlooked, impacting the design of conservation management practices for widely distributed species. We examine processes shaping population divergence in highly mobile species by re-assessing the case of panmixia in the iconic olive ridley turtle from the eastern Pacific. We implemented a biophysical model of connectivity and a seascape genetic analysis based on nuclear DNA variation of 634 samples collected from 27 nesting areas...
May 16, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29717678/communicating-gastrointestinal-symptoms-the-patient-s-challenge
#13
Surinder K Dhaliwal, Richard H Hunt, David Armstrong
Gastrointestinal (GI) disorders present with signs that are objective and symptoms that are subjective, evaluable only if an individual can recognize, characterize, describe, and communicate them to a healthcare professional (HCP). The aim of this study was to quantify the extent to which healthcare seekers perceive difficulties in communicating their GI symptoms to HCPs. Interviews were conducted in two settings where individuals were expected to acknowledge experiencing GI symptoms: a tertiary-care, ambulatory GI clinic and the digestive health medication area of a large retail pharmacy...
2018: Critical Reviews in Biomedical Engineering
https://www.readbyqxmd.com/read/29714817/supramolecular-reassembly-of-self-exfoliated-ionic-covalent-organic-nanosheets-for-label-free-detection-of-dsdna
#14
Arindam Mal, Rakesh K Mishra, Vakayil K Praveen, M Abdul Khayum, Rahul Banerjee, Ayyappanpillai Ajayaghosh
Ionic covalent organic nanosheets (iCONs), a member of two-dimensional (2D) nanomaterials family, offer a unique functional platform for wide range of applications. Herein, we explore the potential of an ethidium bromide (EB) based covalent organic framework (EB-TFP) that self-exfoliates in water resulting in 2D ionic covalent organic nanosheets (EB-TFP-iCONs) for the selective detection of double-stranded DNA (dsDNA). In aqueous medium, the self-exfoliated EB-TFP-iCONs reassemble in the presence of dsDNA resulting into hybrid EB-TFP-iCONs-DNA crystalline nanosheets with enhanced fluorescence at 600 nm...
May 1, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29714083/investigation-of-the-cross-section-stratifications-of-icons-using-micro-raman-and-micro-fourier-transform-infrared-ft-ir-spectroscopy
#15
Dimitra Lazidou, Dimitrios Lampakis, Ioannis Karapanagiotis, Costas Panayiotou
No abstract text is available yet for this article.
January 1, 2018: Applied Spectroscopy
https://www.readbyqxmd.com/read/29708885/a-transformative-icon-for-modern-perinatology
#16
EDITORIAL
Zoltán Papp
No abstract text is available yet for this article.
April 30, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29705516/icones-plantarum-malabaricarum-early-18th-century-botanical-drawings-of-medicinal-plants-from-colonial-ceylon
#17
Tinde Van Andel, Ariane Scholman, Mieke Beumer
ETHNOPHARMACOLOGICAL RELEVANCE: From 1640-1796, the Dutch East India Company (VOC) occupied the island of Ceylon (now Sri Lanka). Several VOC officers had a keen interest in the medicinal application of the local flora. The Leiden University Library holds a two-piece codex entitled: Icones Plantarum Malabaricarum, adscriptis nominibus et viribus, Vol. I. & II. (Illustrations of Plants from the Malabar, assigned names and strength). This manuscript contains 262 watercolour drawings of medicinal plants from Sri Lanka, with handwritten descriptions of local names, habitus, medicinal properties and therapeutic applications...
April 27, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29698253/auditory-icon-alarms-are-more-accurately-and-quickly-identified-than-current-standard-melodic-alarms-in-a-simulated-clinical-setting
#18
Richard R McNeer, Danielle Bodzin Horn, Christopher L Bennett, Judy Reed Edworthy, Roman Dudaryk
BACKGROUND: Current standard audible medical alarms are difficult to learn and distinguish from one another. Auditory icons represent a new type of alarm that has been shown to be easier to learn and identify in laboratory settings by lay subjects. In this study, we test the hypothesis that icon alarms are easier to learn and identify than standard alarms by anesthesia providers in a simulated clinical setting. METHODS: Twenty anesthesia providers were assigned to standard or icon groups...
April 26, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29697838/intraspecific-variation-in-the-information-content-of-an-ornament-why-relative-dewlap-size-signals-bite-force-in-some-but-not-all-island-populations-of-anolis-sagrei
#19
Simon Baeckens, Tess Driessens, Katleen Huyghe, Bieke Vanhooydonck, Raoul Van Damme
In many animals, male secondary sexual traits advertise reliable information on fighting capacity in a male-male context. The iconic sexual signaling device of anole lizards, the dewlap, has been extensively studied in this respect. For several territorial anole species (experiencing strong intrasexual selection), there is evidence for a positive association between dewlap size and bite capacity, which is an important determinant of combat outcome in lizards. Intriguingly, earlier studies did not find this expected correlation (relative dewlap size-relative bite force) in the highly territorial brown anole lizard, Anolis sagrei...
April 25, 2018: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/29695645/non-invasive-measurement-of-cardiac-output-in-children-with-repaired-coarctation-of-the-aorta-using-electrical-cardiometry-compared-to-transthoracic-doppler-echocardiography
#20
Luis Altamirano-Diaz, Eva Welisch, Adam A Dempsey, Teresa Sohee Park, Michael Grattan, Kambiz Norozi
Objective
 To evaluate the equivalence of the ICON® electrical cardiometry (EC) haemodynamic monitor to measure cardiac output (CO) relative to transthoracic Doppler echocardiography (TTE) in paediatric patients with repaired coarctation of the aorta (CoA). 
 
 Approach
 A group of n=28 CoA patients and n=27 matched controls were enrolled. EC and TTE were performed synchronously on each participant and CO measurements compared using linear regression and Bland-Altman analysis...
April 26, 2018: Physiological Measurement
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