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Gili Kenet, Assaf Arie Barg, Ulrike Nowak-Göttl
Hemostasis is a dynamic process that starts in utero. The coagulation system evolves with age, as evidenced by marked physiological differences in the concentration of the majority of hemostatic proteins in early life compared with adulthood. This concept, known as "developmental hemostasis," has important biological and clinical implications. Overall, impaired platelet function, along with physiologically reduced levels of vitamin K-dependent and contact coagulation factors, may cause poorer clot firmness even in healthy neonates...
June 18, 2018: Seminars in Thrombosis and Hemostasis
Ohad S Bentur, Galit Sarig, Benjamin Brenner, Giris Jacob
Stress, the nonspecific response to any demand for change, is an adaptive response of the human body to various stimulants. As such, stress-induced hypercoagulation may represent an adaptive response to bleeding. Numerous epidemiological studies have revealed that a correlation exists between stress and thrombotic risk and biochemically, links of the relationship between psychological stress and coagulation pathways have been made. The stress reaction is coupled with neurohormonal changes mediated mainly by the sympathetic neural system and the hypothalamic-pituitary-adrenal axis...
June 18, 2018: Seminars in Thrombosis and Hemostasis
Mohamed Seleem, Mohamed Hassany
Hepatocellular carcinoma (HCC) is the second leading cause of cancer mortality worldwide. Evolution of laparoscopic techniques helps to a great extent in facilitating and replacing the conventional surgical maneuvers. This article describes the novel use of narrow band imaging (NBI) in laparoscopic radiofrequency ablation (LRFA) of exophytic HCC to ensure its adequate ablation. In total, 11 patients with proven HCC were recruited to perform LRFA; NBI were applied during and after completion of ablation session, with NBI, the exophytic HCC appears dark green or blue in color and after start of LRFA; the tumor capsule turned into red color denoting hemoglobin coagulation and vascular damage; in 5 cases and after completion of ablation; the tumor capsule was still dark green or blue denting viability which necessitates needle repositioning and ablation continuation...
June 14, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
Anneza Panagiotou, Marten Trendelenburg, Michael Osthoff
Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality in modern medicine. Early reperfusion accomplished by primary percutaneous coronary intervention is pivotal for reducing myocardial damage in ST elevation AMI. However, restoration of coronary blood flow may paradoxically trigger cardiomyocyte death secondary to a reperfusion-induced inflammatory process, which may account for a significant proportion of the final infarct size. Unfortunately, recent human trials targeting myocardial ischemia/reperfusion (I/R) injury have yielded disappointing results...
2018: Frontiers in Immunology
Bin Liu, Zhenchao Yuan, Chang Yuan Wei
Objective: The incidence rate of thoracic metastasis from breast cancer is increasing. Microwave ablation is one type of clinical therapy used to treat metastatic spine disease, although it can cause protein denaturation and immediate cell death, and coagulative necrosis can occur. Minimally invasive open decompression is associated with lower rates of surgical complications in comparison to traditional open surgery. Therefore, it is an alternative therapeutic option for spinal metastases...
2018: Cancer Management and Research
Yang Zheng, Xiaomin Lou, Peng Yang, Weixian Shi, Yanda Chu, Meishuang Yan, Cuicui Jiang, Di Wu, Yang Pan, Jiachen Zhao, Yang Li, Yusheng Dong, Lijuan Chen, Siqi Liu, Quanyi Wang
Background: To date, there is limited information on the progression of human infections of avian influenza virus A (H7N9). This study investigated differential blood protein profiling of a H7N9-infected family cluster to find a slice of crucial proteins concerning disease attack and virus clearance. Materials and Methods: Plasma samples from one family cluster (including one index case and one asymptomatic case) were collected at four time points. The protein profiles were identified by isobaric tagging for relative and absolute quantification-based quantitative differential LC/MS/MS, and their functional annotations were analyzed by PANTHER and STRING tools...
April 2018: Journal of Global Infectious Diseases
Mohini Yadav, Gauri Chauhan, A K Bhardwaj, P D Sharma
The clinical and etiological pattern of ventilated newborns, their outcome in relation to morbidity and mortality was studied with 50 ventilated newborns, including outborns. M:f ratio was 2.1:1. The most common gestational age 28-36 weeks (60%) and mostly were appropriate for gestational age (66%). Survival rate 40% (20/50) being directly proportional to the gestational age and intrauterine growth pattern ( P < 0.01). Babies by LSCS Lower Segment Cessarian Section survived more than born by normal vaginal delivery (46...
May 2018: Indian Journal of Critical Care Medicine
Maciej Suski, Renata Bokiniec, Monika Szwarc-Duma, Józef Madej, Beata Bujak-Giżycka, Maria Katarzyna Borszewska-Kornacka, Teofila Książek, Agnieszka Grabowska, Cecilie Revhaug, Lars O Baumbusch, Ola D Saugstad, Jacek Józef Pietrzyk, Przemko Kwinta
OBJECTIVE: In the presented study, we aimed to systematically analyze plasma proteomes in cord blood samples from preterm infants stratified by their gestational age to identify proteins and related malfunctioning pathways at birth, possibly contributing to the complications observed among preterm infants. STUDY DESIGN: Preterm newborns were enrolled of three subgroups with different gestation age: newborns born ≤26 (group 1), between 27 and 28 (group 2) and between 29 and 30 (group 3) weeks of gestation, respectively, and compared to the control group of healthy, full-term newborns in respect to their plasma proteome composition...
June 18, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
P Brandicourt, J C Sol, S Aldéa, F Bonneville, P Cintas, D Brauge
INTRODUCTION: Hirayama disease is a rare cervical myelopathy predominantly affecting young adults and mainly found in Asia. It results in a pure motor distal lesion of the upper limbs with slow progression. Dynamic magnetic resonance imaging (MRI), which allows the diagnosis to be made, shows a typical appearance of anterior compression of the cervical spinal cord associated with enlargement of the posterior epidural spaces due to a dilated venous plexus. Surgery is considered when conservative treatment has failed...
June 14, 2018: Neuro-Chirurgie
Dehong Xie, Yudong Zhang, Hao Qu
OBJECTIVES: This study aimed to uncover new potential genes associated with the inflammatory bowel diseases (IBDs). MATERIALS AND METHODS: The datasets GSE36807 and GSE9686 were obtained from Gene Expression Omnibus (GEO). Totally, 24 Crohn's disease (CD) samples, 20 ulcerative colitis (UC) samples and 15 healthy controls in the two datasets were used for our analysis. The differentially expressed genes (DEGs) were identified by limma package. Then, co-expression network was constructed by weighted gene correlation network analysis (WGCNA) package, and co-expression network modules were obtained via clustering method...
June 16, 2018: Scandinavian Journal of Gastroenterology
Yoshinari Takaoka, Naoki Morimoto, Kouichi Miura, Hiroaki Nomoto, Kozue Murayama, Takuya Hirosawa, Shunji Watanabe, Takeshi Fujieda, Mamiko Ttsukui, Hirotoshi Kawata, Toshiro Niki, Norio Isoda, Makoto Iijima, Hironori Yamamoto
Hepatocellular carcinoma (HCC) can be difficult to diagnose and treat in patients with Osler-Rendu-Weber disease due to vascular malformation and regenerative nodular hyperplasia. In addition, percutaneous liver puncture should be avoided for the diagnosis and treatment as the procedure carries a high risk of bleeding. We herein report the successful treatment of HCC in a patient with Osler-Rendu-Weber disease using radiofrequency ablation (RFA) under laparoscopy. A 71-year-old man with Osler-Rendu-Weber disease was admitted to our hospital for the treatment of HCC...
June 16, 2018: Clinical Journal of Gastroenterology
Yosra Bedoui, Jim W Neal, Philippe Gasque
An effective protective inflammatory response in the brain is crucial for the clearance of pathogens (e.g. microbes, amyloid fibrils, prionSC ) and should be closely regulated. However, the CNS seems to have limited tissue resilience to withstand the detrimental effects of uncontrolled inflammation compromising functional recovery and tissue repair. Newly described neuro-immune-regulators (NIREGs) are functionally related proteins regulating the severity and duration of the host inflammatory response. NIREGs such as CD200, CD47 and CX3CL1 are vital for increasing tissue resilience and are constitutively expressed by neurons...
June 16, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
Jiongming Sun, Hangzhou Xu, Haiyan Pei, Yan Jin, Hongmin Li, Chunxia Ma
Benthic Oscillatoria sp. may form dense surface blooms especially under eutrophic and calm conditions, which poses a threat to drinking water safety because it can produce toxic and odorous metabolites. This is the first study to investigate the effect of the conventional coagulant polyaluminium ferric chloride (PAFC) on removal of Oscillatoria sp., and the behavior of Oscillatoria sp. cells in sludges formed from different dosages of PAFC (control, optimum, and overdose system) during storage was also studied...
June 9, 2018: Water Research
B Sobolewska, J Golenko, S Poeschel, C Grimmel, A Gatsiou, K Sopova, T Biedermann, K Schenke-Layland, K Stellos, F Ziemssen
Aflibercept appears to accumulate in systemic circulation following intravitreal injections in therapy of neovascular age-related macular degeneration. This gives raise to the question of whether aflibercept affects platelets and their function such as activation and aggregation, which are substantial in the pathogenesis of an arterial thromboembolic event (ATE). In order to determine the effect of aflibercept in platelet activation, platelets from healthy volunteers were treated with aflibercept and its solvents at equal concentrations (0...
June 14, 2018: Experimental Eye Research
Mahmoud El-Daly, Vivek Krishna Pulakazhi Venu, Mahmoud Saifeddine, Koichiro Mihara, Sean Kang, Paul W M Fedak, Laurie A Alston, Simon A Hirota, Hong Ding, Chris R Triggle, Morley D Hollenberg
Hyperglycaemia is a major contributor to diabetic cardiovascular disease with hyperglycaemia-induced endothelial dysfunction recognized as the initiating cause. Coagulation pathway-regulated proteinase-activated receptors (PARs) that can regulate vascular tone in vivo cause eNOS-mediated endothelium-dependent vasodilation; but, the impact of hyperglycaemia on this vasodilatory action of PAR stimulation and the signalling pathways involved are unknown. We hypothesized that vascular sodium-glucose co-transporter 2 activity and hyperglycaemia-induced oxidative stress involving Src-kinase, EGF receptor-kinase, Rho-kinase and protein-kinase-C biochemical signalling pathways would compromise PAR2-mediated endothelium-dependent vasodilation...
June 13, 2018: Vascular Pharmacology
Matthew Cardinal, Constantino Kantaridis, Tong Zhu, Pengling Sun, Debra D Pittman, John E Murphy, Steven Arkin
BACKGROUND: Tissue factor pathway inhibitor (TFPI) is a protease inhibitor of tissue factor-activated coagulation factor VII (TF-FVIIa) complex and activated factor X (FXa). PF-06741086 is a monoclonal antibody that targets TFPI to increase clotting activity. OBJECTIVES: This study was a randomized, double-blind, sponsor-open, placebo-controlled, single intravenous (IV) or subcutaneous (SC) dose escalation study to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of PF-06741086...
June 16, 2018: Journal of Thrombosis and Haemostasis: JTH
José I Fortea, Carolina Fernández-Mena, Marta Puerto, Cristina Ripoll, Jorge Almagro, Juan Bañares, José M Bellón, Rafael Bañares, Javier Vaquero
Despite being a cardinal experimental model, the induction of cirrhosis in rats by repeated exposure to carbon tetrachloride (CCl4) has low reproducibility. Here, we compared two models of cirrhosis induced by orogastric administration of CCl4 once (CCl4-1xWk) or twice a week (CCl4-2xWk) for 12 weeks in male Sprague-Dawley rats. Control rats received water instead of CCl4. Both CCl4 protocols similarly attenuated body weight gain (p < 0.01 vs. Control). Although both CCl4 protocols increased hepatic fibrosis, portal hypertension and splenomegaly, the magnitude of these alterations was higher and more consistent in CCl4-2xWk rats...
June 15, 2018: Scientific Reports
Gregory R Stettler, Ernest E Moore, Geoffrey R Nunns, Jim Chandler, Erik Peltz, Christopher C Silliman, Anirban Banerjee, Angela Sauaia
BACKGROUND: Goal-directed hemostatic resuscitation based on thrombelastography has a survival benefit compared to conventional coagulation assays. While thrombelastography transfusion thresholds for patients at risk for massive transfusion (MT) have been defined, similar cutoffs do not exist for the other commonly used viscoelastic assay, rotational thromboelastometry (ROTEM). The purpose of this study was to develop ROTEM blood product thresholds in patients at risk for MT. METHODS: ROTEM was assessed in trauma activation patients admitted from 2010 to 2016 (n = 222)...
August 2018: Journal of Surgical Research
Izumi Saito, Toshiyuki Gotoh, Takeshi Watanabe
Collision-coalescence growth of noninertial particles in three-dimensional homogeneous isotropic turbulence is studied. Smoluchowski's coagulation equation describes the evolution of the size distribution of particles in this system. By applying a methodology based on turbulence theory, the equation is shown to have a steady-state solution, which corresponds to the Kolmogorov-type power-law spectrum. Direct numerical simulations of turbulence and Lagrangian particles are conducted. The result shows that the size distribution in a statistically steady state agrees accurately with the theoretical prediction...
May 2018: Physical Review. E
Shuo Wang, Cong Ma, Yin Zhu, Yangkun Yang, Guocheng Du, Ji Li
FeCl3 , quick lime, and cationic polyacrylamide (CPAM) were used for excess sludge conditioning from wastewater treatment plant (WWTP) and the dewatering performance by different chemical conditioners was investigated. Experimental results showed that FeCl3 could make small and concentrated sludge particles. Furthermore, new mineral phase structures for building a dewatering framework were obtained by the addition of quick lime, and the coagulation capacity was enhanced by the formation of colloid hydroxyl polymer, which was induced due to the alkaline environment...
June 15, 2018: Environmental Science and Pollution Research International
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