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Coagulation

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https://www.readbyqxmd.com/read/29471579/extrahemostatic-functions-of-platelets-and-coagulation-factors
#1
Roger J S Preston, Ton Lisman
No abstract text is available yet for this article.
March 2018: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29471230/variations-of-floc-morphology-and-extracellular-organic-matters-eom-in-relation-to-floc-filterability-under-algae-flocculation-harvesting-using-polymeric-titanium-coagulants-ptcs
#2
Weijun Zhang, Rongna Song, Bingdi Cao, Xiaofang Yang, Dongsheng Wang, Xingmin Fu, Yao Song
The work evaluated the algae cells removal efficiency using titanium salt coagulants with different degree of polymerization (PTCs), and the algae cells aggregates and extracellular organic matter (EOM) under chemical flocculation were investigated. The results indicated that PTCs performed well in algae cells flocculation and separation. The main mechanism using PTCs of low alkalisation degree for algae flocculation was associated with charge neutralization, while adsorption bridging and sweep flocculation was mainly responsible for algae removal by PTCs of high alkalisation degree treatment...
February 10, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29470659/impact-of-particulate-air-pollution-on-cardiovascular-health
#3
REVIEW
Zhen An, Yuefei Jin, Juan Li, Wen Li, Weidong Wu
PURPOSE OF REVIEW: Air pollution is established as an independent risk factor for cardiovascular diseases (CVDs). Ambient particulate matter (PM), a principal component of air pollutant, has been considered as a main culprit of the adverse effects of air pollution on human health. RECENT FINDINGS: Extensive epidemiological and toxicological studies have demonstrated particulate air pollution is positively associated with the development of CVDs. Short-term PM exposure can trigger acute cardiovascular events while long-term exposure over years augments cardiovascular risk to an even greater extent and can reduce life expectancy by a few years...
February 22, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29470366/impact-of-angiotensin-converting-enzyme-inhibition-on-platelet-tissue-factor-expression-in-stroke-prone-rats
#4
Marta Brambilla, Paolo Gelosa, Laura Rossetti, Laura Castiglioni, Chiara Zara, Paola Canzano, Elena Tremoli, Luigi Sironi, Marina Camera
OBJECTIVE: Hypertension is a well known risk factor for thrombotic events such as myocardial infarction and stroke. Platelets express tissue factor (TF), the key activator of blood coagulation and thrombus formation. The number of TF-positive platelets increases in pathological conditions characterized by thrombotic complications but whether this occurs in hypertension is unknown. Here we investigated whether platelet TF expression is increased in a hypertensive status through a mechanism acting on megakaryocytes; the phenomenon could be modulated by antihypertensive drug as captopril; angiotensin (AngII) influences platelet TF expression...
February 21, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29469894/radiometric-model-for-coaxial-single-and-multimode-optical-emission-from-double-clad-fiber
#5
Kathy Beaudette, Mathias Strupler, Jian Ren, Brett E Bouma, Caroline Boudoux
Double-clad fibers (DCFs) are versatile waveguides supporting a single-mode core surrounded by a multimode inner cladding. DCFs are increasingly used for multimodal biomedical applications, such as imaging or therapy, for which the core is typically used for coherent illumination and the inner cladding, to support a concurrent modality. Proper optimization is, however, critical to ensure high optical performance and requires accurate modeling of coaxial single- and multimode output beams. In this paper, we present an approach based on geometrical optics and radiometry, which provides a simple and efficient modeling tool for designing and optimizing DCF-based systems...
February 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29469043/viscoelastic-testing-in-liver-disease
#6
Jessica P E Davis, Patrick G Northup, Stephen H Caldwell, Nicolas M Intagliata
Long thought to be hypocoagulable, new evidence suggests cirrhosis patients have "rebalanced" coagulation in the setting of decreased synthesis of both pro- and anti-coagulant factors. Traditional testing like PT/INR reflects only the decreased synthesis of pro-coagulant factors and thus does not correspond to bleeding or clotting risk in this population. In this review, we discuss the use of viscoelastic testing (VET), an assay of global hemostasis in cirrhosis patients. We describe the technique and interpretation of commercially available VET and assess the application of VET in both transplant and non-transplant cirrhosis populations...
March 1, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29468998/effect-of-heat-induced-%C3%AE%C2%BA-casein-dissociation-on-acid-coagulation-of-milk
#7
Daiki Oka, Wataru Ono, Shintarou Ohara, Tomohiro Noguchi, Katsumi Takano
No abstract text is available yet for this article.
February 2018: Journal of Dairy Research
https://www.readbyqxmd.com/read/29468977/the-development-of-new-factor-xa-inhibitors-based-on-amide-synthesis
#8
Dmitry Tarasov, Dmitry Tovbin, Dmitry Malakhov, Arseniy Aybush, Natalia Tserkovnikova, Marina Savelyeva, Dmitry Sychev, Natalia Drozd, Alla Savchenko
BACKGROUND: Factor Xa (FXa) is known to play a central role in a blood coagulation cascade and considered to be one of the most attractive targets for oral anticoagulants of new generation. OBJECTIVE: Our approach for the development of directly acting oral anticoagulants (DOAC), FXa inhibitors was demonstrated in this work. METHOD: Chemical synthesis is the base of our approach for the development of potential inhibitors. In this work, the substances like R1-(CONH)-R2-(CONH)-R3 are being developed, using previously described docking and screening methods, where R1, R2, R3 are some chemical groups, (CONH) are amid bonds connecting R1, R2 and R3...
February 14, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29468795/suboptimal-use-of-pharmacological-venous-thromboembolism-prophylaxis-in-cirrhotic-patients
#9
Linda S Yang, Sumaya Alukaidey, Katherine Croucher, Damian Dowling
BACKGROUND: Cirrhosis was previously perceived as a haemorrhagic disease state due to frequent associations with coagulopathy and bleeding. However, the coagulopathy of cirrhosis is complex with defects in both pro-coagulant and anticoagulant factors. Derangements in common laboratory indices of coagulation do not accurately reflect bleeding risk or protection from thrombotic events. AIM: We aim to assess the rate of pharmacological prophylaxis for VTE among hospital inpatients with cirrhosis and analyse factors associated with prophylaxis being inappropriately withheld...
February 21, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29468001/cerebral-venous-sinus-thrombosis-in-a-patient-with-meningococcal-meningitis
#10
Sudhir Kumar Palat Chirakkara, Abdul Rahim Ali Bakhsh, Aparna Kalyani Pariyadath, Balamurugan Rathinavelu
Meningococcal meningitis has a wide range of neurological complications. However, cerebral venous sinus thrombosis (CVST) following infection with Neisseria meningitidis is uncommon. We report a case of CVST in a 42-year-old male admitted with meningococcal meningitis. The patient was managed with antibiotics. Due to altered coagulation parameters observed in fulminant cases of meningococcemia, deployment of anticoagulation therapy, which would otherwise be the treatment of choice for CVST, is a dilemma.
January 2018: Oman Medical Journal
https://www.readbyqxmd.com/read/29467183/the-search-for-new-antithrombotic-mechanisms-and-therapies-that-may-spare-hemostasis
#11
Edward F Plow, Yunmei Wang, Daniel I Simon
Current antithrombotic drugs, including widely used antiplatelet agents and anticoagulants, are associated with significant bleeding risk, which increases morbidity and mortality. Nevertheless, there is emerging experimental evidence that suggests that the molecular and cellular mechanisms of hemostasis and thrombosis can be separated, thereby raising the possibility of new antithrombotic therapeutic targets with reduced bleeding risk. We summarize some recently emerging examples of agents with antithrombotic activities that seem to spare hemostasis...
February 21, 2018: Blood
https://www.readbyqxmd.com/read/29466901/modified-isth-pregnancy-specific-dic-score-in-parturients-with-liver-rupture-population-based-case-series
#12
Ranit Hizkiyahu, Anat Rabinovich, Jecko Thachil, Eyal Sheiner, Gad Shaked, Gilbert Sebbag, Eli Maymon, Offer Erez
OBJECTIVES: Liver rupture and hematoma are rare life-threatening complications of pregnancy. The aims of the current study are to: (1) characterize in a population-based study all cases of liver hematoma and/or rupture; and (2) validate the utility of the International Society on Thrombosis and Haemostasis (ISTH) modified pregnancy specific disseminated intravascular coagulation (DIC) score in those cases. STUDY DESIGN: A retrospective cohort study including all patients with liver subcapsular hematoma or rupture between the years 1996 and 2012 was conducted...
February 21, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29466779/simultaneous-decomplexation-in-blended-cu-ii-ni-ii-edta-systems-by-electro-fenton-process-using-iron-sacrificing-electrodes
#13
Zilong Zhao, Wenyi Dong, Hongjie Wang, Guanhan Chen, Junyi Tang, Yang Wu
This research explored the application of electro-Fenton (E-Fenton) technique for the simultaneous decomplexation in blended Cu(II)/Ni(II)-EDTA systems by using iron sacrificing electrodes. Standard discharge (0.3 mg L-1 for Cu and 0.1 mg L-1 for Ni in China) could be achieved after 30 min reaction under the optimum conditions (i.e. initial solution pH of 2.0, H2 O2 dosage of 6 mL L-1  h-1 , current density of 20 mA/cm2 , inter-electrode distance of 2 cm, and sulfate electrolyte concentration of 2000 mg L-1 )...
February 13, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29466649/preclinical-efficacy-against-toxic-activities-of-medically-relevant-bothrops-sp-serpentes-viperidae-snake-venoms-by-a-polyspecific-antivenom-produced-in-mexico
#14
Álvaro Segura, María Herrera, Mariángela Vargas, Mauren Villalta, Alfredo Uscanga-Reynell, Guillermo León, José María Gutiérrez
The assessment of the preclinical neutralizing ability of antivenoms in Latin America is necessary to determine their scope of efficacy. This study was aimed at analyzing the neutralizing efficacy of a polyspecific bothropic-crotalic antivenom manufactured by BIRMEX in Mexico against lethal, hemorrhagic, defibrinogenating and in vitro coagulant activities of the venoms of Bothrops jararaca (Brazil), B. atrox (Perú and Colombia), B. diporus (Argentina), B. mattogrossensis (Bolivia), and B. asper (Costa Rica)...
March 2017: Revista de Biología Tropical
https://www.readbyqxmd.com/read/29465772/superhydrophobic-blood-repellent-surfaces
#15
Ville Jokinen, Esko Kankuri, Sasha Hoshian, Sami Franssila, Robin H A Ras
Superhydrophobic surfaces repel water and, in some cases, other liquids as well. The repellency is caused by topographical features at the nano-/microscale and low surface energy. Blood is a challenging liquid to repel due to its high propensity for activation of intrinsic hemostatic mechanisms, induction of coagulation, and platelet activation upon contact with foreign surfaces. Imbalanced activation of coagulation drives thrombogenesis or formation of blood clots that can occlude the blood flow either on-site or further downstream as emboli, exposing tissues to ischemia and infarction...
February 21, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29465204/-diagnostic-value-of-the-homeostasis-parameters-in-sepsis-detecting-in-patients-with-infectious-inflammatory-complications-during-the-postoperative-period
#16
O V Dymova, A A Eremenko, V V Nikoda, O N Vasilieva, A V Bondarenko, N S Bogomolova, Yu E Mikhailov
Purpose of the study was to define the diagnostic value of clinical and laboratory criteria of sepsis during the postop- erative period Methods. The results of 269 blood tests (biochemical, coagulation, hematology and microbiology) which were per- formed in 115 patients in the early postoperative period (starting from the first postoperative day) and in the late post- operative periods were analyzed. RESULTS: Presepsin and procalcitonin have a similar diagnostic sensitivity in detection of sepsis - 89% (Psp>328...
September 2017: Anesteziologiia i Reanimatologiia
https://www.readbyqxmd.com/read/29464726/changes-in-d-dimer-concentration-after-soft-tissue-and-orthopedic-surgery-in-dogs
#17
Anna Shipov, Josh Milgram, Nitzan Shalev, Itamar Aroch, Gilad Segev
OBJECTIVE: D-dimer is a specific marker of active coagulation and fibrinolysis. The objective of this study is to determine the influence of surgery on D-dimer concentration as well as to examine the relation between the magnitude of change and invasiveness of the surgical procedures. STUDY DESIGN: Prospective clinical study. ANIMALS: Forty-five client-owned dogs undergoing elective neutering (n = 15), elective orthopedic (n = 15), or posttraumatic orthopedic (n = 15) surgical procedures...
February 21, 2018: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29464022/anticoagulants-inhibit-proteolytic-clearance-of-plasma-amyloid-beta
#18
Lu Yang, Arup Bhattacharya, Yun Li, Yuesheng Zhang
We recently discovered a plasma proteolysis pathway, termed the FXII-FVII pathway which is composed of coagulation proteases, and found it to be mainly responsible for the clearance of Aβ42 in the plasma in mice. Aβ42 and Aβ40 are the main Aβ forms in Alzheimer's disease (AD). In the present study, in vitro assays, wild type (WT) mice and J20 mice (a transgenic AD model) are used to assess the degradation of Aβ40 and Aβ42 by the FXII-FVII pathway and the impact of anticoagulants on such degradation. Four clinically available and mechanistically distinct anticoagulants are evaluated, including dabigatran, enoxaparin (EP), rivaroxaban and warfarin...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29463570/correction-enzymatic-lipid-oxidation-by-eosinophils-propagates-coagulation-hemostasis-and-thrombotic-disease
#19
Stefan Uderhardt, Jochen A Ackermann, Tobias Fillep, Victoria J Hammond, Johann Willeit, Peter Santer, Manuel Mayr, Markus Biburger, Meike Miller, Katie R Zellner, Konstantin Stark, Alexander Zarbock, Jan Rossaint, Irene Schubert, Dirk Mielenz, Barbara Dietel, Dorette Raaz-Schrauder, Cihan Ay, Thomas Gremmel, Johannes Thaler, Christian Heim, Martin Herrmann, Peter W Collins, Gernot Schabbauer, Nigel Mackman, David Voehringer, Jerry L Nadler, James J Lee, Steffen Massberg, Manfred Rauh, Stefan Kiechl, Georg Schett, Valerie B O'Donnell, Gerhard Krönke
No abstract text is available yet for this article.
February 20, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29463368/preparation-and-biocompatibility-evaluation-of-peg-pll-rgd-peg-dspe-phospholipid-cap-nanoparticles
#20
Jingwen Huang, Xiangyu Zhang, Zhihao Wu, Yufeng Wu, Xiaojie Wu, Yunguang Wang, Hao Jiang, Jing Ma, Zelai He
(Arginine-Glycine-Aspartic)-methoxy polyethylene glycol-(1,2-distearoyl-sn-glycero-3-phosphoethanolaMine-N) (abbreviation: RGD-PEG2000-DSPE or RGD-PD) was successfully synthesized and verified by 1H-NMR and MALDI-TOF MS. Polyethylene glycol-poly-L-lysine/RGD-PD/phospholipid/calcium phosphate nanoparticles (PEG-PLL/RGD-PD/PL/CaP NPs or MNPs) were prepared using a novel, simple method conducted at room temperature. Transmission electron microscopy (TEM) analysis showed that the MNPs were spheres of uniform size, with a diameter of ∼30 nm, and smooth surface...
January 1, 2018: Journal of Biomedical Nanotechnology
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