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Constance C F M J Baaten, Frauke Swieringa, Tomasz Misztal, Tom G Mastenbroek, Marion A H Feijge, Paul E Bock, Marjo M P C Donners, Peter W Collins, Renhao Li, Paola E J van der Meijden, Johan W M Heemskerk
The platelet receptors glycoprotein Ibα (GPIbα) and GPVI are known to be cleaved by members of a disintegrin and metalloprotease (ADAM) family (ADAM10 and ADAM17), but the mechanisms and consequences of this shedding are not well understood. Our results revealed that (1) glycoprotein shedding is confined to distinct platelet populations showing near-complete shedding, (2) the heterogeneity between (non)shed platelets is independent of agonist type but coincides with exposure of phosphatidylserine (PS), and (3) distinct pathways of shedding are induced by elevated Ca2+ , low Ca2+ protein kinase C (PKC), or apoptotic activation...
September 25, 2018: Blood Advances
Purva V Sharma, Yash B Jobanputra, Tatiana Perdomo Miquel, J Ryan Schroeder, Adam Wellikoff
A 63-year-old man presented with intermittent, progressively worsening dyspnoea associated with cough and blood-tinged sputum. Initial work-up showed left axis deviation on ECG, chest X-ray with an elevated left hemidiaphragm and a non-contrast CT chest that showed a multilobulated mass in the proximal trachea. Bronchoscopy showed a whitish-appearing lesion, which was then sampled and partially resected with pathology showing a schwannoma with no malignant cells. He felt partial relief post procedure; however, he presented a month later with similar symptoms of dyspnoea and a repeat CT scan showed enlargement of the mass in the same location...
September 18, 2018: BMJ Case Reports
Dmitry Zavlin, Vishwanath Chegireddy, Kevin T Jubbal, Nikhil A Agrawal, Aldona J Spiegel
BACKGROUND:  Maintaining optimal coagulation is vital for successful microvascular tissue transfer. The viscoelastic thromboelastography (TEG) is a modern and dynamic method to assess a patient's coagulation status. The aim of this study was to evaluate its diagnostic capabilities of identifying microvascular complications. METHODS:  A retrospective chart review was conducted for the most recent 100 cases of abdominal free flap breast reconstruction of a single surgeon...
September 19, 2018: Journal of Reconstructive Microsurgery
Matthew A Borgman, Morten Zaar, James K Aden, Zachary J Schlader, Daniel Gagnon, Eric Rivas, Jena Kern, Victor A Convertino, Andrew P Cap, Craig G Crandall
Heat stress followed by an accompanying hemorrhagic challenge may influence hemostasis. We tested the hypothesis that hemostatic responses are increased by passive heat stress, and exercise-induced heat stress, each with accompanying central hypovolemia to simulate a hemorrhagic insult. In Aim 1, subjects were exposed to passive heating or normothermic time control, each followed by progressive lower-body negative pressure (LBNP) to pre-syncope. In Aim 2 subjects exercised in hyperthermic environmental conditions, with and without accompanying dehydration, each also followed by progressive LBNP to pre-syncope...
September 19, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Q-S Zhao, W Li, D Li, T Liu, J-H Wang, Y Gao, L Yi, R-K Zhao
OBJECTIVE: This study aims to compare clinical efficiency of mechanical thrombectomy combined with rhPro-UK thrombolysis on moderate or severe acute brain infarction. PATIENTS AND METHODS: A total of 90 acute cerebral infarction patients due to artery stenosis or blockade from May 2016 to May 2017 were recruited and randomly assigned into thrombolysis group (N = 30), mechanical thrombectomy (N = 30), and combined treatment group (N = 30). Clinical information was collected...
September 2018: European Review for Medical and Pharmacological Sciences
Bei-Chen Zhang, Xiao-Lei Zhang, Lan-Lan Qin, Hai-Ou Huang
Humic substance (HS) is a main component of dissolved organic matter in the aquatic environment and significantly affects water treatment processes. To investigate the applicability and principle of UV spectrum analysis for coagulation control, laboratory jar tests were conducted with synthetic waters that had varying concentrations of HS and kaolinite. Thus, the influence of water quality conditions on the optimal coagulant dose (OCD) was determined and further correlated to Specific Ultraviolet Absorbance (SUVA254 ) and the ultraviolet spectral slopes of the coagulated water...
October 8, 2018: Huan Jing Ke Xue= Huanjing Kexue
Elisabeth Kemter, Joachim Denner, Eckhard Wolf
PURPOSE OF REVIEW: Porcine islets represent a potentially attractive beta-cell source for xenotransplantation into patients with type 1 diabetes, who are not eligible to islet allo-transplantation due to a lack of suitable human donor organs. Recent progress in genetic engineering/gene editing of donor pigs provides new opportunities to overcome rejection of xeno-islets, to improve their engraftment and insulin secretion capacity, and to reduce the risk for transmission of porcine endogenous retroviruses...
September 18, 2018: Current Diabetes Reports
Ali Jafari, Bahram Kamarehi, Akram Ghasemi
The aim of data article was to evaluate effectiveness of the combined process of coagulation, flocculation and filtration to remove reactive black 19 from solution aqueous. In this data article, alum and ferric chloride were selected as a coagulant for instability of color before ceramic membrane. All experiments were performed in batch conditions. The results showed that more than half of the ceramic membrane is made of silica. The BET surface area of the ceramic membrane was 1.877 m2 g-1 . The size of RB19, alum, and ferric chloride was 996...
August 2018: Data in Brief
Reza Sardari, Noushin Osouleddini
The use of a ceramic membrane is not only a new and modern technique, but reduce the use of chemicals and coagulants as well, and also having high mechanical and chemical resistance reduces costs over consecutive years. The aim of this research was to remove turbidity and biological agents such as Diatoms, Chlorophyte, Cyanophyceae, Protozoa, and Nematodes by using of ceramic membranes. A ceramic pilot plant was designed and constructed. Titanium oxide (TiO2 ) and aluminum oxide (Al2 O3 ) ultrafiltration membrane with the length, diameter and pore sizes of 25 cm, 2...
August 2018: Data in Brief
Tomaz Crochemore, Felicio Aragão Savioli
Liver disease has been considered the prototype of hemorrhagic disease. Disorder in any component of coagulation system can lead to hemorrhage. Deficiency of factor XIII may impair clot strength and clot stabilization and can be accessed by thromboelastometry. We report a case of a patient with a rapid evolution of liver disease who underwent a liver biopsy. Thromboelastometry was performed, evidencing impairment of clot stability. This clotting disorder was corrected with factor XIII concentrate after unsuccessful administration of antifibrinolytic drugs and hepatic biopsy was performed without hemorrhagic complications...
2018: Case Reports in Gastrointestinal Medicine
Scott J Cameron, Hannah Russell, A Phillip Owens
Abdominal aortic aneurysm (AAA) is a degenerative vascular pathology resulting in significant morbidity and mortality in older adults due to rupture and sudden death. Despite 150,000 new cases and nearly 15,000 deaths annually, the only approved treatment for AAA is surgical or endovascular intervention when the risk for aortic rupture is increased. The goal of the scientific community is to develop novel pharmaceutical treatment strategies to reduce the need for surgical intervention. As most clinically-relevant AAAs contain a complex structure of fibrin, inflammatory cells, platelets, and red blood cells in the aneurysmal sac known as an intraluminal thrombus (ILT), antithrombotic therapies have emerged as potential pharmaceutical agents for the treatment of AAA progression...
September 18, 2018: Blood
Timothy D Lyon, Boris Gershman, Paras H Shah, R Houston Thompson, Stephen A Boorjian, Christine M Lohse, Brian A Costello, John C Cheville, Bradley C Leibovich
INTRODUCTION: To develop a risk-stratification model for cancer-specific survival (CSS) following cytoreductive nephrectomy (CN) in the contemporary era. MATERIALS AND METHODS: A retrospective review was performed of 313 patients who underwent CN for M1 renal cell carcinoma (RCC) from 1990 to 2010. To account for the introduction of targeted therapies, timing of surgery was classified as immunotherapy era (1990-2004) or contemporary era (2005-2010). Risk scores were developed to predict CSS using Cox proportional hazards regression models...
September 15, 2018: Urologic Oncology
Shosaku Nomura
No abstract text is available yet for this article.
September 18, 2018: Acta Haematologica
Yasuyuki Inoue, Manabu Matsunawa, Fumiaki Sano, Ikuo Miura
The prognosis for patients who experience hemostatic complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is poor. However, no report has investigated disseminated intravascular coagulation (DIC) caused by the complications of allo-HSCT without infection. Recombinant human soluble thrombomodulin (rhTM) was used to treat 12 episodes of DIC (n = 10; group 1) caused by allo-HSCT complications such as acute graft-versus-host disease (aGVHD) or thrombotic microangiopathy (TMA), and the clinical outcomes were compared with those of historical controls (n = 9; group 2) treated for DIC without rhTM...
September 18, 2018: Acta Haematologica
Meera Sridharan, Kara A Fylling, Aneel A Ashrani, Dong Chen, Ariela L Marshall, C Christopher Hook, Laynalee K Cardel, William L Nichols, Rajiv K Pruthi
BACKGROUND: Coagulation factor V inhibitors (FV-i) may occur in patients with congenital FV deficiency or previously hemostatically normal patients (autoimmune (AI)-FV-i). Most of the published literature is confined to case reports. OBJECTIVE: Describe clinical and laboratory features of AI-FV-i identified through the Special Coagulation Laboratory at Mayo Clinic, Rochester, Minnesota. METHODS: In this retrospective study individuals with FV-i screens performed from January 1999 to February 2017 were identified through the special coagulation laboratory database...
September 5, 2018: Thrombosis Research
Chunyi Zhang, Mingming Zhang, Shushu Song
Hepsin is required for the growth and maintenance of normal morphology, as well as for cell motility and development, initiation of blood coagulation and pro-inflammatory immune response. Here we showed that Cathepsin D (CtsD) as a novel protein is involved in the regulation of hepsin. CtsD destabilizes hepsin by promoting its ubiquitylation and subsequent proteasomal degradation in breast cancer cells. Breast cancer tissue microarray also indicated that hepsin expression was negatively correlated with CtsD by immunohistochemistry...
September 15, 2018: Cancer Letters
Taegyun Park, Won Il Kim, Beom Jin Kim, Hojae Lee, Insung S Choi, Ji Hun Park, Woo Kyung Cho
One-step assembly of iron(III)-tannic acid (Fe3+ -TA) complex forms nanothin (~10 nm) films on various substrates within minutes. In this deposition scheme, however, the film does not grow continuously over time even though Fe3+ -TA complex is still abundant in the coating solution. In this paper, we report that the salt addition dramatically changes the one-off coating characteristic to continuous one, and each salt has its optimum concentration ( CMFT ) that produces maximum film thickness. For detailed investigation of the salt effects, we employed various salts including LiCl, NaCl, KCl, CaCl2 , SrCl2 , BaCl2 , NaBr, and NaNO3 , and found that only cations played an important role in the continuous deposition of the Fe3+ -TA complex, with smaller CMFT values for the cations of higher valency and larger size...
September 18, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Shoujiang Huang, Junjie Chen, Chengjie Lyu, Qi Qin, Xiaoxia Zhao, Zhongmei Chen, Xiaodong Guo, Jinfa Tou
OBJECTIVE: To analyze complications after laparoscopic Ladd operation for intestinal malrotation, related causes and possible solutions. METHODS: Clinical data of 81 neonates who underwent laparoscopic Ladd operations for intestinal malrotation in the Children's Hospital, Zhejiang University School of Medicine between January 2015 and January 2018 were reviewed. The abdominal complications and findings during operation and reoperation were analyzed. RESULTS: Operations were successfully completed in all patients, and there was no patient converted to open surgery...
May 25, 2018: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
M Severyns, R Nevière, D Resiere, T Andriamananaivo, L Decaestecker, H Mehdaoui, G A Odri, J L Rouvillain
Bothrops lanceolatus is an endemic Crotalidae species in Martinique, where approximately 30 cases of envenoming are managed yearly. Envenoming characteristics from Bothrops species include local tissue damage, systemic bleeding, and hemodynamic alterations. We hereby report a case of severe envenomation following B. lanceolatus snakebite to the right calf. Severe local manifestations developed progressively up to the lower limb despite adequate antivenom therapy. Systemic manifestations of venom also occurred, resulting in intensive care therapy...
September 17, 2018: American Journal of Tropical Medicine and Hygiene
Kazuo Koyanagi, Fumihiko Kato, Keita Nakanishi, Soji Ozawa
BACKGROUND: This study aimed to compare the extent of lateral thermal spread of surrounding tissues after the use of advanced bipolar and ultrasonic coagulation and shearing devices. Association between recurrent laryngeal nerve paralysis (RLNP) and such devices was assessed in patients who underwent minimally invasive esophagectomy (MIE). METHODS: LigaSure™ (LS) and Sonicision™ (SONIC) were used. In ex vivo experiments using the porcine muscle, blade temperature and tissue temperature were measured using a thermometer after the activation of both devices...
October 2018: Esophagus: Official Journal of the Japan Esophageal Society
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