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phytochemicals nutraceuticals

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https://www.readbyqxmd.com/read/28290284/uhplc-ms-2-based-approach-for-the-comprehensive-metabolite-profiling-of-bean-vicia-faba-l-by-products-a-promising-source-of-bioactive-constituents
#1
Ibrahim M Abu-Reidah, David Arráez-Román, Ismail Warad, Alberto Fernández-Gutiérrez, Antonio Segura-Carretero
Today, by-products generated from the agro-industrial practices are considered a key source of bioactive and functional components, that can be used for their nutritional and added value properties. New aspects concerning the use of these wastes as by-products in food production additives or supplements with high nutritional and medicinal value have gained substantial interest, due to their possession of economically high-value products. In this sense, the present study describes a thorough characterization of phytochemical compounds from hydro-methanolic extract of broad beans testa by using ultra-high performance liquid chromatography (UHPLC) hyphenated with quadrupole-time-of-flight tandem mass spectrometry (QTOF-MS)...
March 2017: Food Research International
https://www.readbyqxmd.com/read/28289386/traditionally-used-lathyrus-species-phytochemical-composition-antioxidant-activity-enzyme-inhibitory-properties-cytotoxic-effects-and-in-silico-studies-of-l-czeczottianus-and-l-nissolia
#2
Eulogio J Llorent-Martínez, Gokhan Zengin, María L Fernández-de Córdova, Onur Bender, Arzu Atalay, Ramazan Ceylan, Adriano Mollica, Andrei Mocan, Sengul Uysal, Gokalp O Guler, Abdurrahman Aktumsek
Members of the genus Lathyrus are used as food and as traditional medicines. In order to find new sources of biologically-active compounds, chemical and biological profiles of two Lathyrus species (L. czeczottianus and L. nissolia) were investigated. Chemical profiles were evaluated by HPLC-ESI-MS(n), as well as by their total phenolic and flavonoid contents. In addition, antioxidant, enzyme inhibitory, and cytotoxic effects were also investigated. Antioxidant properties were tested by using different assays (DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum, and metal chelation)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28274443/isolation-structures-and-bioactivities-of-the-polysaccharides-from-jujube-fruit-ziziphus-jujuba-mill-a-review
#3
REVIEW
Xiaolong Ji, Qiang Peng, Yuepeng Yuan, Jing Shen, Xueying Xie, Min Wang
Jujube (Ziziphus Jujuba Mill.) has been eaten as a fruit and nutraceutical food in China for thousands of years. Recent phytochemical and pharmacological studies have shown that the polysaccharides are one of major biologically active components of the jujube fruit and have various biological effects, including immunomodulatory, antioxidant, antitumor, hepatoprotective, and hypoglycemic activities, and gastrointestinal-protective effects. Although the extraction and purification of jujube polysaccharides are tedious processes, including different steps of liquid- and solid-phase separation, the polysaccharides have been structurally characterized...
July 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28263865/evaluation-of-antioxidant-potential-enzyme-inhibition-activity-and-phenolic-profile-of-lathyrus-cicera-and-lathyrus-digitatus-potential-sources-of-bioactive-compounds-for-the-food-industry
#4
E J Llorent-Martínez, P Ortega-Barrales, G Zengin, A Mocan, M J Simirgiotis, R Ceylan, S Uysal, A Aktumsek
The genus Lathyrus has great importance in terms of food and agricultural areas. In this study, the in vitro antioxidant activity (phosphomolybdenum, DPPH, ABTS, FRAP, CUPRAC and metal chelating) and enzyme inhibitory activity evaluation (acetyl cholinesterase, butyryl cholinesterase, α-amylase and α-glucosidase) of L. cicera and L. digitatus were investigated, as well as their phytochemical profiles. The screening of the main phytochemical compounds in aerial parts of L. cicera and L. digitatus was carried out by high-performance liquid chromatography with electrospray ionization mass spectrometric detection (HPLC-ESI-MS(n)), observing that flavonoids represent the highest percentage of identified compounds, with abundance of tri- and tetra-glycosilated flavonoids, including acylated ones, especially in L...
March 2, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28261096/antioxidant-activities-metabolic-profiling-proximate-analysis-mineral-nutrient-composition-of-salvadora-persica-fruit-unravel-a-potential-functional-food-and-a-natural-source-of-pharmaceuticals
#5
Asha Kumari, Asish K Parida, Jaykumar Rangani, Ashok Panda
Salvadora persica is a medicinally important plant mainly used in oral hygiene. However, little attention has been given towards the nutritional prominence of this plant. This study encloses the proximate and mineral nutrient contents, amino acid composition, metabolite profiling and antioxidant potential of S. persica fruit. The ripen fruit contained substantial amount of sugars, mineral nutrients, carotenoids, polyphenols and flavonoids. The metabolic profiling of the fruit extract by GC-MS revealed a total of 22 metabolites comprising of sugars, sugar alcohols, organic acids, organic base, and aromatic silica compound...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28208574/complexation-of-phytochemicals-with-cyclodextrin-derivatives-an-insight
#6
REVIEW
Vasanti Suvarna, Parul Gujar, Manikanta Murahari
Natural compounds have been attracting huge attention because of their broad therapeutic properties with specificity in their action in human health care as functional foods, pharmaceuticals and nutraceuticals. However poor bioavailability and reduced bioactivity attributed to poor solubility and instability is the major drawback hindering the incorporation of these therapeutically potential molecules in novel drug delivery systems. Based on the findings of reported research investigations; complexation of poorly water soluble phytochemicals with cyclodextrins has emerged to be a promising approach to improve their aqueous solubility, stability, rate of dissolution and bioavailability...
April 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28190465/butein-in-health-and-disease-a-comprehensive-review
#7
REVIEW
Ganesan Padmavathi, Nand Kishor Roy, Devivasha Bordoloi, Frank Arfuso, Srishti Mishra, Gautam Sethi, Anupam Bishayee, Ajaikumar B Kunnumakkara
BACKGROUND: The risk of suffering from many chronic diseases seems to have made no improvement despite the advancement in medications available in the modern world. Moreover, the use of synthetic chemicals as medications has proved to worsen the scenario due to the various adverse side effects associated with them. PURPOSE: Extensive research on natural medicines provides ample evidence on the safety and efficacy of phytochemicals and nutraceuticals against diverse chronic ailments...
February 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28159282/phytochemical-composition-of-fractions-isolated-from-ten-salvia-species-by-supercritical-carbon-dioxide-and-pressurized-liquid-extraction-methods
#8
Vaida Šulniūtė, Audrius Pukalskas, Petras Rimantas Venskutonis
Ten Salvia species, S. amplexicaulis, S. austriaca, S. forsskaolii S. glutinosa, S. nemorosa, S. officinalis, S. pratensis, S. sclarea, S. stepposa and S. verticillata were fractionated using supercritical carbon dioxide and pressurized liquid (ethanol and water) extractions. Fifteen phytochemicals were identified using commercial standards (some other compounds were identified tentatively), 11 of them were quantified by ultra high pressure chromatography (UPLC) with quadruple and time-of-flight mass spectrometry (Q/TOF, TQ-S)...
June 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28125168/prednisone-treatment-in-infertile-patients-with-oligozoospermia-and-accessory-gland-inflammatory-alterations
#9
D Milardi, G Luca, G Grande, M Ghezzi, N Caretta, G Brusco, G De Filpo, R Marana, A Pontecorvi, R Calafiore, C Foresta, A Garolla
The association between inflammation of the male reproductive system and oligozoospermia has been frequently reported in the clinical work-up of male infertility. To improve sperm parameters in infertile patients with genital inflammation, many phytochemical and nutraceutical drugs are currently being used. However, their use is still empirical and no conclusive data have been provided about their efficacy. The treatment with steroid anti-inflammatory drugs might be useful in reducing inflammation and improving sperm parameters, thus increasing the fertility outcome...
March 2017: Andrology
https://www.readbyqxmd.com/read/28122600/medicinally-active-principles-analysis-of-tephrosia-apollinea-delile-dc-growing-in-the-united-arab-emirates
#10
Abdul J Cheruth, Saif A M Al Baloushi, Kandhan Karthishwaran, Sajid Maqsood, Shyam S Kurup, Sabitha Sakkir
BACKGROUND: Tephrosia apollinea is a leguminous plant and is native to southwest Asia, Arabia, northwestern India and northeast Africa. In traditional system, it is used for medicinal and coloring purpose. The present study aims to explore the phytochemical, proximate analysis, element contents and antioxidant potential of T. apollinea extract. METHODS: The phytochemical screening was done with qualitative methods. Proximate analysis and elemental composition were performed from powdered sample...
January 25, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28122160/physicochemical-properties-antioxidant-and-anti-proliferative-capacities-of-dried-leaf-and-its-extract-from-xao-tam-phan-paramignya-trimera
#11
Van Tang Nguyen, Jennette A Sakoff, Christopher J Scarlett
Xao tam phan (P. trimera) has been used for the treatment of cancer and cancer-like aliments. Among different parts of P. trimera plant, leaf is considered as a residual part after harvesting of the root. This study aimed to determine the physiochemical properties, antioxidant and anti-proliferative capacities of P. trimera leaf (PTL) using microwave drying for the preparation of dry sample; methanol and microwave-assisted extraction for the preparation of crude extract; and freeze drying for the preparation of powdered extract...
January 25, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28120718/nutraceuticals-and-dietary-supplements-to-improve-quality-of-life-and-outcomes-in-heart-failure-patients
#12
Arrigo Fg Cicero, Alessandro Colletti
BACKGROUND: Heart failure (HF) is a complex clinical syndrome that can result from any structural or functional cardiac disorder that impairs the ability of the ventricle to fill or eject blood. It represents a major public health issue, with a prevalence of over 23 million worldwide. The lifetime risk of developing HF is one in five and the most important risk factors identified are ischemic heart disease, hypertension, smoking, obesity and diabetes. Preventive approaches are based on improvements of lifestyle, associated with pharmacological therapy...
January 24, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28056918/fermented-blueberry-juice-extract-and-its-specific-fractions-have-an-anti-adipogenic-effect-in-3%C3%A2-t3-l1-cells
#13
Mayra L Sánchez-Villavicencio, Melinda Vinqvist-Tymchuk, Wilhelmina Kalt, Chantal Matar, Francisco J Alarcón Aguilar, Maria Del Carmen Escobar Villanueva, Pierre S Haddad
BACKGROUND: Obesity and Type 2 diabetes have reached epidemic status worldwide. Wild lowbush blueberry (Vaccinium angustifolium Aiton) is a plant of the North American Aboriginal traditional pharmacopeia with antidiabetic potential, especially when it is fermented with Serratia vaccinii. METHODS: A phytochemical fractionation scheme was used to identify potential bioactive compounds as confirmed by HPLC retention times and UV-Vis spectra. 3 T3-L1 cells were differentiated for 7 days with either Normal Blueberry Extract (NBE), Fermented Blueberry Extract (FBE/F1), seven fractions and four pure compounds...
January 6, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28031235/htp-nutraceutical-screening-for-histone-deacetylase-inhibitors-and-effects-of-hdacis-on-tumor-suppressing-mirnas-by-trichostatin-a-and-grapeseed-vitis-vinifera-in-hela-cells
#14
Elizabeth A Mazzio, Karam F A Soliman
BACKGROUND/AIM: Aggressive tumor malignancies are a consequence of delayed diagnosis, epigenetic/phenotype changes and chemo-radiation resistance. Histone deacetylases (HDACs) are a major epigenetic regulator of transcriptional repression, which are highly overexpressed in advanced malignancy. While original chemotherapy drugs were modeled after phytochemicals elucidated by botanical screenings, HDAC inhibitors (HDACi) such as apicidin, trichostatin A (TSA) and butyrate were discovered as products of fungus and microbes, in particular, gut microbiota...
January 2, 2017: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/27905221/antioxidant-potentiality-of-three-herbal-teas-consumed-in-bandundu-rural-areas-of-congo
#15
Paulin Mutwale Kapepula, Patricia Mbombo Mungitshi, Thierry Franck, Ange Mouithys-Mickalad, Dieudonné Mumba Ngoyi, Pascal Dibungi T Kalenda, Nadege Kabamba Ngombe, Didier Serteyn, Monique Tits, Michel Frédérich, Jean-Jacques Tamfum Muyembe
The aim of this study was to evaluate and compare the cellular antioxidant activities of Lantana montevidensis, Lippia multiflora, and Ocimum gratissimum leaves often consumed as herbal teas in a rural area of Bandundu severely affected by konzo, which is related to oxidative damage. Consequently, dietary supplements with proven antioxidant potentialities could be of real interest to promote in this area. Phytochemical screening by TLC and HPLC-DAD of extracts revealed the presence of verbascoside as a major phenolic compound...
December 1, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27891602/cannabimimetic-phytochemicals-in-the-diet-an-evolutionary-link-to-food-selection-and-metabolic-stress-adaptation
#16
REVIEW
Jürg Gertsch
The endocannabinoid system (ECS) is a major lipid signalling network that plays important pro-homeostatic (allostatic) roles not only in the nervous system but also in peripheral organs. There is increasing evidence that there is a dietary component in the modulation of the ECS. Cannabinoid receptors in hominids co-evolved with diet, and the ECS constitutes a feedback loop for food selection and energy metabolism. Here, it is postulated that the mismatch of ancient lipid genes of hunter-gatherers and pastoralists with the high-carbohydrate diet introduced by agriculture could be compensated for via dietary modulation of the ECS...
November 27, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27854256/natural-deep-eutectic-solvents-nades-as-a-tool-for-bioavailability-improvement-pharmacokinetics-of-rutin-dissolved-in-proline-glycine-after-oral-administration-in-rats-possible-application-in-nutraceuticals
#17
Marta Faggian, Stefania Sut, Beatrice Perissutti, Valeria Baldan, Iztok Grabnar, Stefano Dall'Acqua
There is a need for innovation in plant-derived pharmaceuticals, food supplements and nutraceutical products regarding the use of more eco-sustainable solvents for their extraction. Furthermore, the poor oral bioavailability of several phytochemicals with health promoting effects stimulates the research in the field of pharmaceutical formulations. Natural Deep Eutectic Solvents (NADES) are formed by natural compounds, and can be considered as future solvents being especially useful for the preparation of nutraceuticals and food-grade extracts...
November 14, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27814590/phytochemicals-in-the-treatment-of-ovarian-cancer
#18
Juhi Rais, Asif Jafri, Sahabjada Siddiqui, Madhu Tripathi, Mohammad Arshad
Ovarian cancer ranks 5(th) among the most common gynecologic cancers and causes the highest mortality in females. Here, we discuss the role of a group of natural products that are being used in treatment and prevention of a host of cancers including ovarian cancer. Some plants and nutraceuticals and their polyphenolic constituents such as flavones, flavonoids, and antioxidants have shown cytotoxic effects on cancer cells both in vitro and in vivo. While phytochemicals do not harm normal cells, they have been found to be cytotoxic to cancer cells by virtue of inhibition of proliferation and/or induction of apoptosis, making them ideal in cancer therapeutics or as adjunct to conventional treatment regimens...
January 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/27775146/wild-fragaria-vesca-l-fruits-a-rich-source-of-bioactive-phytochemicals
#19
Maria Inês Dias, Lillian Barros, Patricia Morales, Montaña Cámara, Maria José Alves, M Beatriz P P Oliveira, Celestino Santos-Buelga, Isabel C F R Ferreira
Wild Fragaria vesca L. fruits were studied regarding nutritional and phytochemical compounds, and also antioxidant, antibacterial and biofilm formation inhibition activities. The fruits are good sources of carbohydrates (e.g., sucrose), soluble dietary fiber and polyunsaturated fatty acids, mainly linoleic and linolenic acids, as well as other components such as citric and succinic acids, and vitamins B9 and E (mainly γ-tocopherol). Significant amounts of soluble sugars, citric acid and some amounts of ascorbic acid, vitamins B9 and E (only α-tocopherol) were found also in the infusions...
November 9, 2016: Food & Function
https://www.readbyqxmd.com/read/27706034/neurodegenerative-diseases-might-citrus-flavonoids-play-a-protective-role
#20
REVIEW
Santa Cirmi, Nadia Ferlazzo, Giovanni E Lombardo, Elvira Ventura-Spagnolo, Sebastiano Gangemi, Gioacchino Calapai, Michele Navarra
Neurodegenerative diseases (ND) result from the gradual and progressive degeneration of the structure and function of the central nervous system or the peripheral nervous system or both. They are characterized by deterioration of neurons and/or myelin sheath, disruption of sensory information transmission and loss of movement control. There is no effective treatment for ND, and the drugs currently marketed are symptom-oriented, albeit with several side effects. Within the past decades, several natural remedies have gained attention as potential neuroprotective drugs...
September 30, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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