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phytochemicals nutraceuticals

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https://www.readbyqxmd.com/read/29164416/high-throughput-and-direct-measurement-of-androgen-levels-using-turbulent-flow-chromatography-liquid-chromatography-triple-quadrupole-mass-spectrometry-tfc-lc-tqms-to-discover-chemicals-that-modulate-dihydrotestosterone-production-in-human-prostate-cancer-cells
#1
Kyungsu Kang, Lei Peng, Yu-Jin Jung, Joo Yeon Kim, Eun Ha Lee, Hee Ju Lee, Sang Min Kim, Sang Hyun Sung, Cheol-Ho Pan, Yongsoo Choi
OBJECTIVES: To develop a high-throughput screening system to measure the conversion of testosterone to dihydrotestosterone (DHT) in cultured human prostate cancer cells using turbulent flow chromatography liquid chromatography-triple quadrupole mass spectrometry (TFC-LC-TQMS). RESULTS: After optimizing the cell reaction system, this method demonstrated a screening capability of 103 samples, including 78 single compounds and 25 extracts, in less than 12 h without manual sample preparation...
November 21, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/29140273/larix-decidua-bark-as-a-source-of-phytoconstituents-an-lc-ms-study
#2
Valeria Baldan, Stefania Sut, Marta Faggian, Elena Dalla Gassa, Sara Ferrari, Gabriele De Nadai, Stefano Francescato, Gianni Baratto, Stefano Dall'Acqua
Larix decidua bark is a waste of the timber industry and is widely diffused in Northern Italy. This material can be considered a good source of antioxidants and phytoconstituents with possible use in cosmetic or nutraceutical products. In this study, simple extraction of larch bark was performed using mixtures of ethanol/water. Furthermore, the phytochemical composition of larch bark extract was studied using LC-MS(n) methods and the main constituents were identified as flavonoids, spiro-polyphenols, and procyanidins...
November 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29129015/melanoma-inhibition-by-anthocyanins-is-associated-with-the-reduction-of-oxidative-stress-biomarkers-and-changes-in-mitochondrial-membrane-potential
#3
Zoriţa Diaconeasa, Huseyin Ayvaz, Dumitriţa Ruginǎ, Loredana Leopold, Andreea Stǎnilǎ, Carmen Socaciu, Flaviu Tăbăran, Lavinia Luput, Diana Carla Mada, Adela Pintea, Andrew Jefferson
Anthocyanins are water soluble pigments which have been proved to exhibit health benefits. Several studies have investigated their effects on several types of cancer, but little attention has been given to melanoma. The phytochemical content of nine different berry samples was assessed by liquid chromatography followed by electrospray ionization mass spectrometry (LC-ESI(+)-MS). Twenty-six anthocyanins were identified, after a previous C18 Sep-pak clean-up procedure. Chokeberry and red grape anthocyanins rich extracts (C-ARE and RG-ARE) were selected to be tested on normal and melanoma cell lines, due to their different chemical pattern...
November 11, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/29105630/a-hepatonephro-protective-phenolic-rich-extract-from-red-onion-allium-cepa-l-peels
#4
Atallah F Ahmed, Hanan M Al-Yousef, Jawaher H Al-Qahtani, Mansour S Al-Said
Onion peel is a common bio-waste, occasionally used in traditional medicine in treatment of liver ailment and inflammation. However, a phytochemical and biological study is further required to provide the scientific evidence for this use. A phenolic-rich extract of red onion peels (coded as ACPE) was primarily prepared and then subjected to chromatographic separation. From the extract, six phenolic antioxidant compounds along with two phytosterols were isolated and identified by means of spectroscopic (NMR and MS) analyses...
September 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29104253/lipophilic-fraction-of-cultivated-bifurcaria-bifurcata-r-ross-detailed-composition-and-in-vitro-prospection-of-current-challenging-bioactive-properties
#5
Sónia A O Santos, Stephanie S Trindade, Catia S D Oliveira, Paula Parreira, Daniela Rosa, Maria F Duarte, Isabel Ferreira, Maria T Cruz, Andreia M Rego, Maria H Abreu, Silvia M Rocha, Armando J D Silvestre
Macroalgae have been seen as an alternative source of molecules with promising bioactivities to use in the prevention and treatment of current lifestyle diseases. In this vein, the lipophilic fraction of short-term (three weeks) cultivated Bifurcaria bifurcata was characterized in detail by gas chromatography-mass spectrometry (GC-MS). B. bifurcata dichloromethane extract was composed mainly by diterpenes (1892.78 ± 133.97 mg kg(-1) dry weight (DW)), followed by fatty acids, both saturated (550.35 ± 15.67 mg kg(-1) DW) and unsaturated (397...
November 1, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29084170/ethnobotanic-ethnopharmacologic-aspects-and-new-phytochemical-insights-into-moroccan-argan-fruits
#6
REVIEW
Farid Khallouki, Mohamed Eddouks, Akdad Mourad, Andrea Breuer, Robert Wyn Owen
This review summarizes available data on argan fruit botany, geographical distribution, traditional uses, environmental interest, socioeconomic role, phytochemistry, as well as health beneficial effects and examination of future prospects. In particular, ethnomedical uses of argan fruits are carried out throughout Morocco where it has been used against various diseases. Different classes of bioactive compounds have been characterized including essential oils, fatty acids, triacylglycerols, flavonoids and their newly reported acylglycosyl derivatives, monophenols, phenolic acids, cinnamic acids, saponins, triterpenes, phytosterols, ubiquinone, melatonin, new aminophenols along with vitamin E among other secondary metabolites...
October 30, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29034183/alzheimer-disease-clues-from-traditional-and-complementary-medicine
#7
REVIEW
Edwin L Cooper, Melissa J Ma
Despite modern medicine's incredible innovation and resulting accumulation of valuable knowledge, many of the world's most problematic diseases such as Alzheimer Disease (AD) still lack effective cures and treatments. Western medicine has revealed many genetic, cellular, and molecular processes that characterize AD such as protein aggregation and inflammation. As the need for novel and effective treatments increases, researchers have turned towards traditional medicine as a resource. Modern, evidence based research examining traditional and complementary remedies for AD has generated promising results within the last decade...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29027830/occurrence-types-properties-and-interactions-of-phenolic-compounds-with-other-food-constituents-in-oil-bearing-plants
#8
Muhammad H Alu'datt, Taha Rababah, Mohammad N Alhamad, Ghaid J Al-Rabadi, Carole C Tranchant, Ali Almajwal, Stan Kubow, Inteaz Alli
Phenolic phytochemicals have become of interest due to their therapeutic potential, particularly with regards to their anti-cancer, anti-inflammatory, hypolipidemic, and hypoglycemic properties. An evolving area of research involving phenolics in foods and their products pertains to the functional, biological, and nutritional consequences resulting from the binding between certain phenolic compounds and the macronutrient and micronutrient constituents of foods. The goal of this review is to provide a summary of studies investigating endogenous phenolic interactions with major components in food systems, including carbohydrates, proteins, lipids, minerals and vitamins, with a focus on the phenolic compounds and nutrients in oil-bearing plants...
October 13, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28964373/phenolic-composition-profiling-of-different-edible-parts-and-by-products-of-date-palm-phoenix-dactylifera-l-by-using-hplc-dad-esi-ms-n
#9
Ibrahim M Abu-Reidah, Ángel Gil-Izquierdo, Sonia Medina, Federico Ferreres
Fruits and vegetables are an important source of dietary antioxidants and epidemiological studies show that their regular intake in the diet may decrease the risk of several chronic diseases. Phoenix dactylifera L. (date palm or dates) is an important crop, widely used in the Arabian region and in other parts of the world as a food and also in folk medicine, due to its health-promoting properties. Antioxidant phytochemicals present in plant foods are partly responsible for such health benefits. The antioxidants present in dates are mainly phenolics, like flavonoids and phenolic acids...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28946635/hypopigmenting-effects-of-brown-algae-derived-phytochemicals-a-review-on-molecular-mechanisms
#10
REVIEW
Mohammed Shariful Azam, Jinkyung Choi, Min-Sup Lee, Hyeung-Rak Kim
There is a rapid increase in the demand for natural hypopigmenting agents from marine sources for cosmeceutical and pharmaceutical applications. Currently, marine macroalgae are considered as a safe and effective source of diverse bioactive compounds. Many research groups are exploring marine macroalgae to discover and characterize novel compounds for cosmeceutical, nutraceutical, and pharmaceutical applications. Many types of bioactive secondary metabolites from marine algae, including phlorotannins, sulfated polysaccharides, carotenoids, and meroterpenoids, have already been documented for their potential applications in the pharmaceutical industry...
September 24, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28946340/lycium-ruthenicum-studies-molecular-biology-phytochemistry-and-pharmacology
#11
REVIEW
Hanqing Wang, Jiaoning Li, Weiwei Tao, Xia Zhang, Xiaojuan Gao, Jingjiao Yong, Jianjun Zhao, Liming Zhang, Yongzhou Li, Jin-Ao Duan
Lycium ruthenicum has been used as ethnic medicine and nutraceutical food. Existing studies of L. ruthenicum can be classifies into three areas: (1) those in which molecular biology methods were used to study its origin, genetic variation and relationships with other species; (2) those in which phytochemical methods were used to extract, isolate, and identify compounds; and (3) those in which pharmacological methods were used to study active compounds. The purpose of this paper is to provide an overview of L...
February 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28933290/nutraceuticals-and-repurposed-drugs-of-phytochemical-origin-in-prevention-and-interception-of-chronic-degenerative-disease-and-cancer
#12
Adriana Albini, Barbara Bassani, Denisa Baci, Katiuscia Dallaglio, Matteo Gallazzi, Paola Corradino, Antonino Bruno, Douglas M Noonan
Chronic, degenerative diseases are often characterized by inflammation and aberrant angiogenesis. For many of these pathologies, including rheumatoid arthritis, cardiovascular and autoimmune diseases, cancer, diabetes, and obesity, current therapies have limited efficacy, thus the validation of novel (chemo)preventive and interceptive approaches, of new or repurposed agents, alone or in combination with registered drugs, are urgently required. Phytochemicals (triterpenoids, flavonoids, retinoids) and their derivatives, non-steroidal anti-inflammatory drugs (aspirin) as well as biguanides (metformin and phenformin) originally developed from phytochemical backbones, are multi-target agents showing anti-angiogenic and anti-anti-inflammatory proprieties...
September 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28912082/mapk-signalling-pathway-in-cancers-olive-products-as-cancer-preventive-and-therapeutic-agents
#13
REVIEW
Ilaria Peluso, Nagendra Sastry Yarla, Roberto Ambra, Gianni Pastore, George Perry
The mitogen-activated protein kinases (MAPKs) are fundamental in inflammation and cancer control, through the crosstalk between the redox regulated nuclear factor E2-related factor 2 (Nrf2) and nuclear factor-kB (NFκB) gene expression. MAPKs regulate various cellular activities involved in cancer progression, including proliferation, apoptosis and immune escape and blockade of upstream kinases is a current therapeutic strategy. However, these therapies are associated with some adverse effects and with the paradoxical activation of the MAPKs pathway...
September 11, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28794929/high-frequency-direct-shoot-organogenesis-of-leaf-explants-and-a-comparative-evaluation-of-phytochemicals-antioxidant-potential-of-wild-vs-in-vitro-plant-extracts-of-lysimachia-laxa
#14
Sanjoy Gupta, Tapan Seal, A A Mao, Soneswar Sarma
The present studies were attempted to develop direct shoot organogenesis from in vitro grown leaf explants of Lysimachia laxa and comparative evaluation of phytochemical and antioxidant potential of in vitro raised and wild plants extracts. The fresh leaves of this species are used for deworming gastrointestinal worm infection in traditional medicine. Overexploitation of this species and poor regeneration has led to rapid decline in wild population, therefore, present investigation was attempted to develop an efficient rapid mass propagation protocol for this species...
August 2017: 3 Biotech
https://www.readbyqxmd.com/read/28791945/comparison-of-various-extraction-techniques-of-medicago-sativa-yield-antioxidant-activity-and-content-of-phytochemical-constituents
#15
Aneta Krakowska, Katarzyna Rafińska, Justyna Walczak, Tomasz Kowalkowski, Bogusław Buszewski
Medicago sativa L. (M. sativa) is a source of many valuable secondary metabolites. Extraction yield and the concentration of phenolics, flavonoids, and saponins, as well as antioxidant potential were determined in extracts from different parts of M. sativa obtained using extraction methods such as maceration, ultrasound-assisted extraction (UAE), accelerated solvent extraction (ASE), and supercritical fluid extraction (SFE). The concentrations of the listed groups of compounds were spectrophotometrically determined and confirmed by HPLC-MS...
July 13, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28749445/a-metabolomics-guided-exploration-of-the-phytochemical-constituents-of-vernonia-fastigiata-with-the-aid-of-pressurized-hot-water-extraction-and-liquid-chromatography-mass-spectrometry
#16
Keabetswe Masike, Bradley S Khoza, Paul A Steenkamp, Elize Smit, Ian A Dubery, Ntakadzeni E Madala
Vernonia fastigiata is a multi-purpose nutraceutical plant with interesting biological properties. However, very little is known about its phytochemical composition and, thus the need for its phytochemical characterization. In the current study, an environmentally friendly method, pressurized hot water extraction (PHWE), was used to extract metabolites from the leaves of V. fastigiata at various temperatures (50 °C, 100 °C, 150 °C and 200 °C). Ultra-high performance liquid chromatography-quadrupole time of flight mass spectrometry (UHPLC-qTOF-MS) analysis in combination with chemometric methods, particularly principal component analysis (PCA) and liquid/gas chromatography mass spectrometry (XCMS) cloud plots, were used to descriptively visualize the data and identify significant metabolites extracted at various temperatures...
July 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28698131/white-grape-pomace-extracts-obtained-by-a-sequential-enzymatic-plus-ethanol-based-extraction-exert-antioxidant-anti-tyrosinase-and-anti-inflammatory-activities
#17
Maura Ferri, Greta Rondini, Maria Maddalena Calabretta, Elisa Michelini, Veronica Vallini, Fabio Fava, Aldo Roda, Giordano Minnucci, Annalisa Tassoni
The present work aimed at optimizing a two-step enzymatic plus solvent-based process for the recovery of bioactive compounds from white grape (Vitis vinifera L., mix of Trebbiano and Verdicchio cultivars) pomace, the winemaking primary by-product. Phenolic compounds solubilised by water enzyme-assisted and ethanol-based extractions of wet (WP) and dried (DP) pomace were characterised for composition and tested for antioxidant, anti-tyrosinase and anti-inflammatory bioactivities. Ethanol treatment led to higher phenol yields than water extraction, while DP samples showed the highest capacity of releasing polyphenols, most probably as a positive consequence of the pomace drying process...
July 8, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28658963/chemical-composition-and-physicochemical-properties-of-phaeodactylum-tricornutum-microalgal-residual-biomass
#18
L J German-Báez, M A Valdez-Flores, J V Félix-Medina, C D Norzagaray-Valenzuela, D U Santos-Ballardo, C Reyes-Moreno, L M Shelton, A Valdez-Ortiz
The production of photosynthetic biofuels using microalgae is a promising strategy to combat the use of non-renewable energy sources. The microalgae residual biomass is a waste by-product of biofuel production; however, it could prove to have utility in the development of sustainable nutraceuticals and functional foods. In this study, a comprehensive characterisation of the under-utilised Phaeodactylum tricornutum microalgae residual biomass is presented. Proximal composition, antioxidant capacity (using three different antioxidant assays; oxygen radical absorbance capacity; radical cation activity, ABTS; and radical scavenging activity, DPPH), and total phenolic content of free and bound polyphenols were determined...
January 1, 2017: Food Science and Technology International, Ciencia y Tecnología de Los Alimentos Internacional
https://www.readbyqxmd.com/read/28657580/phytochemicals-targeting-estrogen-receptors-beneficial-rather-than-adverse-effects
#19
REVIEW
Sylvain Lecomte, Florence Demay, François Ferrière, Farzad Pakdel
In mammals, the effects of estrogen are mainly mediated by two different estrogen receptors, ERα and ERβ. These proteins are members of the nuclear receptor family, characterized by distinct structural and functional domains, and participate in the regulation of different biological processes, including cell growth, survival and differentiation. The two estrogen receptor (ER) subtypes are generated from two distinct genes and have partially distinct expression patterns. Their activities are modulated differently by a range of natural and synthetic ligands...
June 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28630399/dietary-mastic-oil-extracted-from-pistacia-lentiscus-var-chia-suppresses-tumor-growth-in-experimental-colon-cancer-models
#20
Katerina Spyridopoulou, Angeliki Tiptiri-Kourpeti, Evangeli Lampri, Eleni Fitsiou, Stavros Vasileiadis, Manolis Vamvakias, Haido Bardouki, Anna Goussia, Vasiliki Malamou-Mitsi, Mihalis I Panayiotidis, Alex Galanis, Aglaia Pappa, Katerina Chlichlia
Plant-derived bioactive compounds attract considerable interest as potential chemopreventive anticancer agents. We analyzed the volatile dietary phytochemicals (terpenes) present in mastic oil extracted from the resin of Pistacia lentiscus var. chia and comparatively investigated their effects on colon carcinoma proliferation, a) in vitro against colon cancer cell lines and b) in vivo on tumor growth in mice following oral administration. Mastic oil inhibited - more effectively than its major constituents- proliferation of colon cancer cells in vitro, attenuated migration and downregulated transcriptional expression of survivin (BIRC5a)...
June 19, 2017: Scientific Reports
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