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https://www.readbyqxmd.com/read/29232719/qtl-mapping-of-antixenosis-resistance-to-common-cutworm-spodoptera-litura-fabricius-in-wild-soybean-glycine-soja
#1
Nobuhiko Oki, Akito Kaga, Takehiko Shimizu, Masakazu Takahashi, Yuhi Kono, Motoki Takahashi
The common cutworm (CCW; Spodoptera litura Fabricius) is a serious herbivorous insect pest of soybean (Glycine max) in Asia and Oceania. Previously, we identified quantitative trait loci (QTLs) for CCW-antibiosis-resistance, CCW-1 and CCW-2, and antixenosis-resistance, qRslx1 and qRslx2, in the cultivar 'Himeshirazu'. The effects of these QTLs are useful in the breeding of CCW-resistant cultivars. In this study, we conducted an antixenosis bioassay on CCW using recombinant inbred lines derived from a cross between a wild soybean (Glycine soja) and the leading cultivar 'Fukuyutaka' to identify CCW-resistance genes in G...
2017: PloS One
https://www.readbyqxmd.com/read/29232299/the-axillary-intra-aortic-balloon-pump-as-a-bridge-to-recovery-allows-early-ambulation-in-long-term-use-case-series-and-literature-review
#2
Nnamdi Nwaejike, Andre Y Son, Chetan B Patel, Jacob N Schroder, Carmelo A Milano, Mani A Daneshmand
We evaluated the feasibility, tolerability, and efficacy of a strategy for transaxillary artery intra-aortic balloon pump placement for extended mechanical circulatory support of patients with postcardiotomy shock as a bridge to recovery. Patients requiring prolonged intra-aortic balloon pump support for postcardiotomy heart failure were identified. Intra-aortic balloon pump was tunneled through a 6-mm Dacron graft anastomosed to the right axillary artery. The intra-aortic balloon pump catheter is advanced under fluoroscopic guidance into the descending thoracic aorta...
December 7, 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29232142/janus-iron-oxides-semiconducting-polymer-nanoparticle-tracer-for-cell-tracking-by-magnetic-particle-imaging
#3
Guosheng Song, Min Chen, Yanrong Zhang, Liyang Cui, Haibo Qu, Xianchuang Zheng, Max Wintermark, Zhuang Liu, Jianghong Rao
Iron oxides nanoparticles tailored for magnetic particle imaging (MPI) have been synthesized, and their MPI signal intensity is 3 times of commercial MPI contrast (Ferucarbotran, also called Vivotrax) and 7 times of MRI contrast (Feraheme) at the same Fe concentration. MPI tailored iron oxide nanoparticles were encapsulated with semiconducting polymers to produce Janus nanoparticles that possessed optical and magnetic properties for MPI and fluorescence imaging. Janus particles were applied to cancer cell labeling and in vivo tracking, and as few as 250 cells were imaged by MPI after implantation, corresponding to an amount of 7...
December 12, 2017: Nano Letters
https://www.readbyqxmd.com/read/29231428/-electroacupuncture-combined-with-catgut-implantation-for-postoperative-pain-of-mixed-hemorrhoids
#4
Yong Wen, Jun Li, Qing Long, Xiaolin Lan, Ye Chen
OBJECTIVE: To compare the clinical effect differences among electroacupuncture (EA) combined with catgut implantation, simple EA and simple catgut implantation for postoperative pain of mixed hemorrhoids. METHODS: A total of 120 patients were randomly assigned into a combination group, an EA group, and a catgut implantation group, 40 cases in each one. All the interventions were applied for 30 min before the operation. The acupoints were Changqiang (GV 1) and Chengshan (BL 57)...
March 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29230570/the-relationship-between-systolic-vector-flow-mapping-parameters-and-left-ventricular-cardiac-function-in-healthy-dogs
#5
Seijirow Goya, Tomoki Wada, Kazumi Shimada, Daiki Hirao, Ryou Tanaka
Vector flow mapping (VFM) is a novel echocardiographic technology that shows blood flow vectors and vortexes, enabled the hydrokinetic evaluation of hemodynamics within the left ventricle. VFM provides several unique parameters: circulation, vorticity, vortex area, and energy loss. The present study aims to reveal a relationship between VFM parameters and cardiac function. Five healthy Beagle dogs were anesthetized and administered with dobutamine (0, 2, 4, 8, 12 µg/kg/min). Pressure-volume diagrams were acquired to assess cardiac function using pressure-volume conductance catheter...
December 11, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29230535/a-new-method-for-non-invasive-biomass-determination-based-on-stereo-photogrammetry
#6
Maria Syngelaki, Matthias Hardner, Patrick Oberthuer, Thomas Bley, Danilo Schneider, Felix Lenk
A novel, non-destructive method for the biomass estimation of biological samples on culture dishes was developed. To achieve this, a photogrammetric system, which consists of a digital single-lens reflex camera (DSLR), an illuminated platform where the culture dishes are positioned and an Arduino board which controls the capturing process, was constructed. The camera was mounted on a holder which set the camera at different title angles and the platform rotated, to capture images from different directions. A software, based on stereo photogrammetry, was developed for the three-dimensional (3D) reconstruction of the samples...
December 11, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/29230256/design-and-evaluation-of-a-robotic-device-for-automated-tail-vein-cannulations-in-rodent-models
#7
Alex Fromholtz, Max L Balter, Alvin I Chen, Josh M Leipheimer, Anil Shrirao, Timothy J Maguire, Martin L Yarmush
Preclinical testing in rodent models is a ubiquitous part of modern biomedical research and commonly involves accessing the venous bloodstream for blood sampling and drug delivery. Manual tail vein cannulation is a time-consuming process and requires significant skill and training, particularly since improperly inserted needles can affect the experimental results and study outcomes. In this paper, we present a miniaturized, robotic medical device for automated, image-guided tail vein cannulations in rodent models...
December 2017: Journal of Medical Devices
https://www.readbyqxmd.com/read/29230012/estimation-of-immune-cell-content-in-tumour-tissue-using-single-cell-rna-seq-data
#8
Max Schelker, Sonia Feau, Jinyan Du, Nav Ranu, Edda Klipp, Gavin MacBeath, Birgit Schoeberl, Andreas Raue
As interactions between the immune system and tumour cells are governed by a complex network of cell-cell interactions, knowing the specific immune cell composition of a solid tumour may be essential to predict a patient's response to immunotherapy. Here, we analyse in depth how to derive the cellular composition of a solid tumour from bulk gene expression data by mathematical deconvolution, using indication-specific and cell type-specific reference gene expression profiles (RGEPs) from tumour-derived single-cell RNA sequencing data...
December 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/29229500/diagnostic-value-of-circulating-cell-free-dna-levels-for-hepatocellular-carcinoma
#9
Linlin Yan, Yanhui Chen, Jiyuan Zhou, Hong Zhao, Henghui Zhang, Guiqiang Wang
OBJECTIVES: Circulating cell-free DNA (cfDNA) is a potential biomarker for tumor diagnosis. Hepatocyte damage is characteristic component of the pathobiology of hepatocellular carcinoma (HCC), which would be expected to result in substantial leakage of cfDNA into the circulation. However, the diagnostic value of cfDNA levels for HCC remains unclear. METHODS: Plasma samples were collected from 24 HCC patients and 62 HBV-related liver fibrosis patients. Plasma cfDNA levels was quantified by Qubit method...
December 8, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29229386/the-interaction-of-soybean-reticulon-homology-domain-protein-gmrhp-with-soybean-mosaic-virus-encoded-p3-contributes-to-the-viral-infection
#10
Xiaoyan Cui, Lu Lu, Ying Wang, Xingxing Yuan, Xin Chen
Soybean mosaic virus (SMV), a member of the Potyvirus genus, is a prevalent and devastating viral pathogen in soybean-growing regions worldwide. Potyvirus replication occurs in the 6K2-induced viral replication complex at endoplasmic reticulum exit sites. Potyvirus-encoded P3 is also associated with the endoplasmic reticulum and is as an essential component of the viral replication complex, playing a key role in viral replication. This study provides evidence that the soybean (Glycine max) reticulon homology domain protein (designated as GmRHP) interacts with SMV P3 by using a two-hybrid yeast system to screen a soybean cDNA library...
December 8, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29229324/comparison-of-36%C3%A2-gy-20%C3%A2-gy-or-no-radiation-therapy-after-6-cycles-of-ebvp-chemotherapy-and-complete-remission-in-early-stage-hodgkin-lymphoma-without-risk-factors-results-of-the-eort-gela-h9-f-intergroup-randomized-trial
#11
José Thomas, Christophe Fermé, Evert M Noordijk, Franck Morschhauser, Théodore Girinsky, Isabelle Gaillard, Pieternella J Lugtenburg, Marc André, Marnix L M Lybeert, Aspasia Stamatoullas, Max Beijert, Philippe Hélias, Houchingue Eghbali, Jean Gabarre, Richard W M van der Maazen, Jérôme Jaubert, Krimo Bouabdallah, Olivier Boulat, Judith M Roesink, Bernard Christian, Francisca Ong, Dominique Bordessoule, Gérard Tertian, Hugo Gonzalez, Andrej Vranovsky, Philippe Quittet, Umberto Tirelli, Daphne de Jong, Josée Audouin, Berthe M P Aleman, Michel Henry-Amar
PURPOSE: While patients with early-stage Hodgkin lymphoma (HL) have an excellent outcome with combined treatment, the radiation therapy (RT) dose and treatment with chemotherapy alone remain questionable. This noninferiority trial evaluates the feasibility of reducing the dose or omitting RT after chemotherapy. METHODS AND MATERIALS: Patients with untreated supradiaphragmatic HL without risk factors (age ≥ 50 years, 4 to 5 nodal areas involved, mediastinum-thoracic ratio ≥ 0...
October 27, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29228924/the-photosynthetic-and-structural-differences-between-leaves-and-siliques-of-brassica-napus-exposed-to-potassium-deficiency
#12
Zhifeng Lu, Yonghui Pan, Wenshi Hu, Rihuan Cong, Tao Ren, Shiwei Guo, Jianwei Lu
BACKGROUND: Most studies of photosynthesis in chlorenchymas under potassium (K) deficiency focus exclusively on leaves; however, little information is available on the physiological role of K on reproductive structures, which play a critical role in plant carbon gain. Brassica napus L., a natural organ-succession species, was used to compare the morphological, anatomical and photo-physiological differences between leaves and siliques exposed to K-deficiency. RESULTS: Compared to leaves, siliques displayed considerably lower CO2 assimilation rates (A) under K-deficient (-K) or sufficient conditions (+K), limited by decreased stomatal conductance (g s), apparent quantum yield (α) and carboxylation efficiency (CE), as well as the ratio of the maximum rate of electron transport (J max) and the maximum rate of ribulose 1,5-bisphosphate (RuBP) carboxylation (V cmax)...
December 11, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29228587/chronic-myeloid-leukemia-progenitor-cells-require-autophagy-when-leaving-hypoxia-induced-quiescence
#13
Angela Ianniciello, Pierre-Yves Dumas, Claire Drullion, Amélie Guitart, Arnaud Villacreces, Yan Peytour, Jean Chevaleyre, Philippe Brunet de la Grange, Isabelle Vigon, Vanessa Desplat, Muriel Priault, Persio Dello Sbarba, Zoran Ivanovic, François-Xavier Mahon, Jean-Max Pasquet
Albeit tyrosine kinase inhibitors anti-Abl used in Chronic Myeloid Leukemia (CML) block the deregulated activity of the Bcr-Abl tyrosine kinase and induce remission in 90% of patients, they do not eradicate immature hematopoietic compartments of leukemic stem cells. To elucidate if autophagy is important for stem cell survival and/or proliferation, we used culture in low oxygen concentration (0.1% O2 for 7 days) followed back by non-restricted O2 supply (normoxic culture) to mimic stem cell proliferation and commitment...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228489/s2k-leitlinie-kutane-lymphome-update-2016-teil-1-klassifikation-und-diagnostik-icd10-c82-c86
#14
Edgar Dippel, Chalid Assaf, Jürgen C Becker, Michael von Bergwelt-Baildon, Marc Beyer, Antonio Cozzio, Hans Theodor Eich, Markus Follmann, Stephan Grabbe, Uwe Hillen, Wolfram Klapper, Claus-Detlev Klemke, Cristina Lamos, Carmen Loquai, Frank Meiß, Dominik Mestel, Dorothee Nashan, Jan P Nicolay, Ilske Oschlies, Max Schlaak, Christoph Stoll, Tibor Vag, Michael Weichenthal, Marion Wobser, Rudolf Stadler
No abstract text is available yet for this article.
December 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29227992/thalamocortical-control-of-propofol-phase-amplitude-coupling
#15
Austin E Soplata, Michelle M McCarthy, Jason Sherfey, Shane Lee, Patrick L Purdon, Emery N Brown, Nancy Kopell
The anesthetic propofol elicits many different spectral properties on the EEG, including alpha oscillations (8-12 Hz), Slow Wave Oscillations (SWO, 0.1-1.5 Hz), and dose-dependent phase-amplitude coupling (PAC) between alpha and SWO. Propofol is known to increase GABAA inhibition and decrease H-current strength, but how it generates these rhythms and their interactions is still unknown. To investigate both generation of the alpha rhythm and its PAC to SWO, we simulate a Hodgkin-Huxley network model of a hyperpolarized thalamus and corticothalamic inputs...
December 11, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29227333/illustrative-cases-for-monitoring-by-quantitative-analysis-of-braf-nras-ctdna-mutations-in-liquid-biopsies-of-metastatic-melanoma-patients-who-gained-clinical-benefits-from-anti-pd1-antibody-therapy
#16
Teofila Seremet, Simon Planken, Max Schreuer, Yanina Jansen, Mélanie Delaunoy, Hakim El Housni, Danielle Lienard, Véronique Del Marmol, Pierre Heimann, Bart Neyns
Anti-programmed death 1 (PD-1) monoclonal antibodies improve the survival of metastatic melanoma patients. Predictive or monitoring biomarkers for response to this therapy could improve the clinical management of these patients. To date, no established biomarkers are available for monitoring the response to immunotherapy. Tumor- specific mutations in circulating tumor DNA (ctDNA) such as BRAF and NRAS mutations for melanoma patients have been proposed for monitoring of immunotherapy response. We present seven illustrative cases for the use of ctDNA BRAF and NRAS mutations' monitoring in plasma...
December 8, 2017: Melanoma Research
https://www.readbyqxmd.com/read/29227169/descriptive-study-of-the-relationship-between-the-subclinical-carotid-disease-and-biomarkers-carotid-femoral-pulse-wave-velocity-in-patients-with-hypertension
#17
XiaoXiao Zhao, Liujin Bo, Hongwei Zhao, Lihong Li, Yingyan Zhou, Hongyu Wang
BACKGROUND: Carotid intima-media thickness (cIMT) is a significant early prediction signal for preclinical atherosclerosis. Plasma homocysteine (Hcy) level is an independent risk factor for cardiovascular diseases. Pulse wave velocity (PWV), an index of arterial stiffness (AS), has showed its value in the evaluation of AS in vascular-related diseases. The data regarding the relationships between cIMT and other indices of vascular damage are limited and partly controversial. We aim to investigate the relationships between cIMT and other indices of vascular damage such as Hcy and carotid femoral PWV (CF-PWV)...
December 11, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29227055/does-the-reporting-of-gastro-intestinal-endoscopy-meet-the-minimal-terminology-standard-at-king-edward-viii-hospital
#18
S P Maharaj, M A Noorbhai, T E Madiba
BACKGROUND: The Minimal Standard Terminology (MST) was developed to standardise endoscopic reporting. This study is aimed at assessing current reporting at a tertiary hospital and whether it meets this Minimal Standard Terminology. METHOD: This was a retrospective observational study of upper endoscopy reports between January and December 2014. The data extracted were compared to the current reporting standard listed in the MST. To assess and grade the quality of reporting we developed a Gastrointestinal Reporting Score, which incorporates MST variables in addition to demographic details, indication for endoscopy, report legibility, sedation and the use of classification systems to describe pathology...
November 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/29227034/the-clinical-course-of-late-life-bipolar-disorder-looking-back-and-forward
#19
Annemiek Dols, Nicole Korten, Hannie Comijs, Sigfried Schouws, Moniek van Dijk, Ursula Klumpers, Aartjan Beekman, Ralph Kupka, Max Stek
OBJECTIVES: Little is known about the course of late-life bipolar disorder (LLBD). First, we studied patients with LLBD retrospectively with regard to age at first mood episode, onset polarity, predominant polarity and episode density and its associations with other clinical variables. Next, we examined prospectively the clinical course and its associated factors. METHODS: Data were used from a dynamic cohort (Dutch Older Bipolars [DOBi]) including 101 patients with LLBD (mean age of 68...
December 11, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/29226386/theranostic-2d-tantalum-carbide-mxene
#20
Han Lin, Youwei Wang, Shanshan Gao, Yu Chen, Jianlin Shi
The large-dimensional and rigid ceramic bulks fabricated by high-temperature solid-phase reaction and sintering have never been considered for possibly entering and circulating within the blood vessels for biomedical applications, especially on combating cancer. Here, it is reported for the first time that MAX ceramic biomaterials exhibit unique functionalities for dual-mode photoacoustic/computed tomography imaging and are highly effective for in vivo photothermal ablation of tumors upon being exfoliated into ultrathin nanosheets within atomic thickness (MXene)...
December 11, 2017: Advanced Materials
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