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https://www.readbyqxmd.com/read/29667720/mycophenolate-mofetil-administered-every-8-hours-in-combination-with-tacrolimus-is-efficacious-in-the-prophylaxis-of-acute-graft-versus-host-disease-in-childhood-adolescent-and-young-adult-allogeneic-stem-cell-transplantation-recipients
#1
Olga Militano, Mehmet F Ozkaynak, Brinda Mehta, Carmella van deVen, Carl Hamby, Mitchell S Cairo
BACKGROUND: The optimal dose and schedule of mycophenolate mofetil (MMF) in pediatric allogeneic stem cell transplant recipients remains to be determined. We previously reported safety and pharmacokinetics of MMF at 900 mg/m2 q6h dosing. This study was conducted to investigate the efficacy of tacrolimus plus q8h MMF dosing for acute graft versus host disease (GVHD) prophylaxis in a heterogeneous population of children, adolescent, young adult allogeneic stem cell transplant recipients, utilizing multiple allogeneic donor sources...
April 18, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29667657/unrivalled-diversity-the-many-roles-and-reactions-of-bacterial-cytochromes-p450-in-secondary-metabolism
#2
REVIEW
Anja Greule, Jeanette E Stok, James J De Voss, Max J Cryle
Covering: 2000 up to 2018The cytochromes P450 (P450s) are a superfamily of heme-containing monooxygenases that perform diverse catalytic roles in many species, including bacteria. The P450 superfamily is widely known for the hydroxylation of unactivated C-H bonds, but the diversity of reactions that P450s can perform vastly exceeds this undoubtedly impressive chemical transformation. Within bacteria, P450s play important roles in many biosynthetic and biodegradative processes that span a wide range of secondary metabolite pathways and present diverse chemical transformations...
April 18, 2018: Natural Product Reports
https://www.readbyqxmd.com/read/29667491/optimization-of-3d-print-material-for-the-recreation-of-patient-specific-temporal-bone-models
#3
Max Haffner, Austin Quinn, Tsung-Yen Hsieh, E Bradley Strong, Toby Steele
OBJECTIVE: Identify the 3D printed material that most accurately recreates the visual, tactile, and kinesthetic properties of human temporal bone Subjects and Methods: Fifteen study participants with an average of 3.6 years of postgraduate training and 56.5 temporal bone (TB) procedures participated. Each participant performed a mastoidectomy on human cadaveric TB and five 3D printed TBs of different materials. After drilling each unique material, participants completed surveys to assess each model's appearance and physical likeness on a Likert scale from 0 to 10 (0 = poorly representative, 10 = completely life-like)...
May 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29667078/impact-of-different-coarctation-therapies-on-aortic-stiffness-phase-contrast-mri-study
#4
Michal Schäfer, Gareth J Morgan, Max B Mitchell, Michael Ross, Alex J Barker, Kendall S Hunter, Brian Fonseca, Michael DiMaria, Daniel Vargas, D Dunbar Ivy, Neil Wilson, Lorna P Browne
Coarctation of the aorta has been associated with increased thoracic aortic stiffness in adolescents and young adults. However, the effects of different therapeutic strategies on aortic stiffness in a young population is unknown. This study aimed to non-invasively assess aortic stiffness between different repair or intervention strategies in patients with coarctation of the aorta. Forty-nine coarctation patients who underwent either surgery (n = 26), balloon angioplasty (n = 14), or stent implantation (n = 12), and 26 age- and size-matched normotensive healthy controls underwent evaluation of thoracic aortic stiffness and flow hemodynamics via phase-contrast cardiac magnetic resonance...
April 17, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29667073/spirituality-experiences-in-hemophilia-patients-a-phenomenological-study
#5
Masoume Rambod, Farkhondeh Sharif, Zahra Molazem, Kate Khair
Spirituality plays an important role in coping with chronic diseases. However, the meaning of spirituality is not known in hemophilia, as a chronic disease. This study aimed to explore the essence of spirituality in hemophilia patients. This qualitative study with a hermeneutic phenomenological approach was conducted on twelve Muslim adult hemophilia patients. The participants were selected using purposeful sampling. The data were gathered through interview. Then, the data were analyzed using thematic analysis and van Manen's methodological framework...
April 17, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29667014/automatically-computed-ecg-algorithm-for-the-quantification-of-myocardial-scar-and-the-prediction-of-mortality
#6
Patrick Badertscher, Ivo Strebel, Ursina Honegger, Nicolas Schaerli, Deborah Mueller, Christian Puelacher, Max Wagener, Roger Abächerli, Joan Walter, Zaid Sabti, Lorraine Sazgary, Stella Marbot, Jeanne du Fay de Lavallaz, Raphael Twerenbold, Jasper Boeddinghaus, Thomas Nestelberger, Nikola Kozhuharov, Tobias Breidthardt, Samyut Shrestha, Dayana Flores, Carmela Schumacher, Damian Wild, Stefan Osswald, Michael J Zellweger, Christian Mueller, Tobias Reichlin
BACKGROUND: Myocardial scar is associated with adverse cardiac outcomes. The Selvester QRS-score was developed to estimate myocardial scar from the 12-lead ECG, but its manual calculation is difficult. An automatically computed QRS-score would allow identification of patients with myocardial scar and an increased risk of mortality. OBJECTIVES: To assess the diagnostic and prognostic value of the automatically computed QRS-score. METHODS: The diagnostic value of the QRS-score computed automatically from a standard digital 12-lead was prospectively assessed in 2742 patients with suspected myocardial ischemia referred for myocardial perfusion imaging (MPI)...
April 17, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29666918/procedure-specific-assessment-tool-for-flexible-pharyngo-laryngoscopy-gathering-validity-evidence-and-setting-pass-fail-standards
#7
Jacob Melchiors, K Petersen, T Todsen, A Bohr, Lars Konge, Christian von Buchwald
OBJECTIVE: The attainment of specific identifiable competencies is the primary measure of progress in the modern medical education system. The system, therefore, requires a method for accurately assessing competence to be feasible. Evidence of validity needs to be gathered before an assessment tool can be implemented in the training and assessment of physicians. This evidence of validity must according to the contemporary theory on validity be gathered from specific sources in a structured and rigorous manner...
April 17, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29666861/lactoferrin-preserves-bone-homeostasis-by-regulating-the-rankl-rank-opg-pathway-of-osteoimmunology
#8
Fengjiao Fan, Pujie Shi, Meng Liu, Hui Chen, Maolin Tu, Weihong Lu, Ming Du
Osteoporosis can be classified as an inflammatory disease and the crosstalk between the immune system and bone growth should be considered. The effects of bovine lactoferrin on bone by osteoimmunology were investigated in the present study. Ten week old female BALB/c mice were ovariectomized (OVX) and fed for 12 weeks with a control diet or lactoferrin (2, 20 and 100 mg kg-1 d-1). The results showed that following 12 weeks of treatment after surgery, OVX resulted in bone loss, but treatment with lactoferrin preserved bone homeostasis...
April 18, 2018: Food & Function
https://www.readbyqxmd.com/read/29666630/the-interactomic-analysis-reveals-pathogenic-protein-networks-in-phomopsis-longicolla-underlying-seed-decay-of-soybean
#9
Shuxian Li, Bryan Musungu, David Lightfoot, Pingsheng Ji
Phomopsis longicolla T. W. Hobbs (syn. Diaporthe longicolla ) is the primary cause of Phomopsis seed decay (PSD) in soybean, Glycine max (L.) Merrill. This disease results in poor seed quality and is one of the most economically important seed diseases in soybean. The objectives of this study were to infer protein-protein interactions (PPI) and to identify conserved global networks and pathogenicity subnetworks in P. longicolla including orthologous pathways for cell signaling and pathogenesis. The interlog method used in the study identified 215,255 unique PPIs among 3,868 proteins...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29666537/antioxidant-and-antidiabetic-activities-of-vanadium-binding-proteins-purified-from-the-sea-squirt-halocynthia-roretzi
#10
Minoli Anuththara Gunasinghe, Sang Moo Kim
Sea squirts accumulate vanadium compounds with potent antidiabetic activity, which are involved in immune defense. In this study, vanadium concentrations of fresh blood plasma, intestine, and muscle of the sea squirt Halocynthia roretzi were 6.3, 3.7 and 2.1 mg/kg respectively. Two vanadium binding proteins (VBPs) from blood plasma and intestine were purified through (NH4 )2 SO4 precipitation, and DEAE-Sepharose ion exchange and Sephacryl S-200 HR gel filtration chromatography, in that order. The purity and yield of the intestine and blood plasma vanadium binding proteins, VBPintestine and VBPblood plasma, were 13...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29666329/codon-usage-vis-a-vis-start-and-stop-codon-context-analysis-of-three-dicot-species
#11
Prosenjit Paul, Arup Kumar Malakar, Supriyo Chakraborty
To understand the variation in genomic composition and its effect on codon usage, we performed the comparative analysis of codon usage and nucleotide usage in the genes of three dicots, Glycine max, Arabidopsis thaliana and Medicago truncatula. The dicot genes were found to be A/T rich and have predominantly A-ending and/or T-ending codons. GC3s directly mimic theusage pattern of global GC content. Relative synonymous codon usage analysis suggests that the high usage frequency of A/T over G/C mononucleotide containing codons in AT-rich dicot genome is due to compositional constraint as a factor of codon usage bias...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29666265/an-explainable-deep-machine-vision-framework-for-plant-stress-phenotyping
#12
Sambuddha Ghosal, David Blystone, Asheesh K Singh, Baskar Ganapathysubramanian, Arti Singh, Soumik Sarkar
Current approaches for accurate identification, classification, and quantification of biotic and abiotic stresses in crop research and production are predominantly visual and require specialized training. However, such techniques are hindered by subjectivity resulting from inter- and intrarater cognitive variability. This translates to erroneous decisions and a significant waste of resources. Here, we demonstrate a machine learning framework's ability to identify and classify a diverse set of foliar stresses in soybean [ Glycine max (L...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29665854/a-community-based-physical-activity-intervention-to-prevent-mobility-related-disability-for-retired-older-people-retirement-in-action-react-study-protocol-for-a-randomised-controlled-trial
#13
Afroditi Stathi, Janet Withall, Colin J Greaves, Janice L Thompson, Gordon Taylor, Antonieta Medina-Lara, Colin Green, James Bilzon, Selena Gray, Heidi Johansen-Berg, Claire E Sexton, Max J Western, Jolanthe L de Koning, Jessica C Bollen, Sarah J Moorlock, Naiara Demnitz, Poppy Seager, Jack M Guralnik, W Jack Rejeski, Ken R Fox
BACKGROUND: The REtirement in ACTion (REACT) study is a multi-centre, pragmatic, two-arm, parallel-group randomised controlled trial (RCT) with an internal pilot phase. It aims to test the effectiveness and cost-effectiveness of a community, group-based physical activity intervention for reducing, or reversing, the progression of functional limitations in older people who are at high risk of mobility-related disability. METHODS/DESIGN: A sample of 768 sedentary, community-dwelling, older people aged 65 years and over with functional limitations, but who are still ambulatory (scores between 4 and 9 out of 12 in the Short Physical Performance Battery test (SPPB)) will be randomised to receive either the REACT intervention, delivered over a period of 12 months by trained facilitators, or a minimal control intervention...
April 17, 2018: Trials
https://www.readbyqxmd.com/read/29665763/neuroimaging-radiological-interpretation-system-niris-for-acute-traumatic-brain-injury-tbi
#14
Max Wintermark, Ying Li, Victoria Y Ding, Yingding Xu, Bin Jiang, Robyn L Ball, Michael Zeineh, Alisa Gean, Pina Sanelli
To develop an outcome-based NeuroImaging Radiological Interpretation System (NIRIS) for acute traumatic brain injury (TBI) patients that would standardize the interpretation of non-contrast head CTs and consolidate imaging findings into ordinal severity categories that would inform specific patient management actions and that could be used as a clinical decision support tool. We retrospectively identified all patients transported to our emergency department by ambulance or helicopter, for whom a trauma alert was triggered per established criteria and who underwent a non-contrast head CT due to suspicion of TBI, between November 2015 and April 2016...
April 18, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29665737/increased-synthesis-of-a-new-oleanane-type-saponin-in-hairy-roots-of-marigold-calendula-officinalis-after-treatment-with-jasmonic-acid
#15
Michał Markowski, Marek Długosz, Anna Szakiel, Mathieu Durli, Sophie Poinsignon, Sabine Bouguet-Bonnet, Lionel Vernex-Loset, Gabriel Krier, Max Henry
Native plant of marigold (Calendula officinalis L.) synthesizes oleanolic acid saponins classified as glucosides or glucuronides according to the first residue in sugar chain bound to C-3 hydroxyl group. Hairy root culture, obtained by transformation with Agrobacterium rhizogenes strain 15834, exhibit a potent ability of synthesis of oleanolic acid glycosides. The HPLC profile of saponin fraction obtained from C. officinalis hairy roots treated with plant stress hormone, jasmonic acid, showed the 10-times increase of the content of one particular compound, determined by NMR and MALDI TOF as a new bisdesmoside saponin, 3-O-β-d-glucuronopyranosyl-28-O-β-d-galactopyranosyl-oleanolic acid...
April 18, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29665614/vo2max-testing-in-trail-runners-is-there-a-specific-exercise-test-protocol
#16
Volker Scheer, Katharina Ramme, Claus Reinsberger, Hans-Christian Heitkamp
Trail running places specific physiological demands on the human body due to its uphill and downhill running sections. We developed and investigated a more sport-specific trail exercise test protocol (inclination and speed incremental protocol), and compared it to two standard exercise test protocols (horizontal step and ramp protocol) in thirteen highly trained trail runners (age 31±6 years, height 179±6.4 cm, weight 69.2±7.9 kg, BMI 21.6±2.1 kg/m2 ). The maximum oxygen uptake (VO2 max) measured during the trail test (62...
April 17, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29665613/the-association-between-self-rated-fitness-and-cardiorespiratory-fitness-in-adults
#17
Karina Gregersen Jensen, Susanne Rosthøj, Allan Linneberg, Mette Aadahl
To assess criterion validity of a single item question on self-rated physical fitness against objectively measured cardiorespiratory fitness. From the Health2008 study 749 men and women between 30 and 60 years of age rated their fitness as excellent, very good, good, fair or poor. Cardiorespiratory fitness was estimated with the watt-max test. Agreement between self-rated and objectively measured physical fitness was assessed by Cohen's weighted kappa coefficient. Correlation was determined by Goodman & Kruskal's gamma correlation coefficient...
April 17, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29665519/associations-between-cognitive-functioning-mood-symptoms-and-coping-styles-in-older-age-bipolar-disorder
#18
Nadine P G Paans, Annemiek Dols, Hannie C Comijs, Max L Stek, Sigfried N T M Schouws
BACKGROUND: Older age patients with bipolar disorder (OABD) have often passive coping styles, generally considered as detrimental for functioning. The aim of the current study is to identify the contribution of cognitive functioning, subjective cognitive complaints and mood symptoms to passive and active coping styles in older age BD. METHODS: In 90 euthymic patients (age > 60) with BD I or II, we examined coping, neuropsychological profile including memory, attention, executive function and fluency, subjective cognitive complaints and mood symptoms...
April 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29665205/characterization-of-the-in-vitro-and-in-vivo-properties-of-cfz533-a-blocking-and-non-depleting-anti-cd40-monoclonal-antibody
#19
Jacinda Ristov, Pascal Espie, Peter Ulrich, Denise Sickert, Thierry Flandre, Mirela Dimitrova, Dorothee Müller-Ristig, Doris Weider, Gautier Robert, Patrick Schmutz, Barbara Greutmann, Francisco Cordoba-Castro, Martin A Schneider, Max Warncke, Frank Kolbinger, Serge Cote, Christoph Heusser, Christian Bruns, James S Rush
The CD40-CD154 co-stimulatory pathway is essential for T cell-dependent immune responses, development of humoral memory and antigen presenting cell function. These immune functions have been implicated in the pathology of multiple autoimmune diseases as well as allograft rejection. We have generated CFZ533, a fully human, pathway blocking anti-CD40 monoclonal antibody that has been modified with a N297A mutation to render it unable to mediate Fcγ-dependent effector functions. CFZ533 inhibited CD154-induced activation of human leukocytes in vitro, but failed to induce human leukocyte activation...
April 17, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29665047/neural-reward-responsiveness-in-children-who-engage-in-nonsuicidal-self-injury-an-erp-study
#20
Aliona Tsypes, Max Owens, Greg Hajcak, Brandon E Gibb
BACKGROUND: A better understanding of the correlates of nonsuicidal self-injury (NSSI) in children is important for the identification and prevention of future suicide risk. However, although abnormalities in reward responsiveness might constitute one potential transdiagnostic mechanism of risk for NSSI, no studies have examined initial response to reward in children with a history of NSSI. The goal of the present study was to address this important gap in the literature. To objectively assess initial response to reward, we utilized the feedback negativity (FN) event-related potential, a well-established psychophysiological marker of reward responsiveness...
April 17, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
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