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Shuyan Zhao, Tiankun Liang, Tao Zhou, Dongqi Li, Bohui Wang, Jingjing Zhan, Lifen Liu
Perfluorooctane sulfonamide (FOSA) is an important perfluorooctane sulfonate (PFOS) precursor used for commercial applications. In order to investigate the transformation and responses of selected antioxidant and degradation enzymes of FOSA in the plants, in vivo exposure of soybean (Glycine max L. Merrill) and pumpkin (Cucurbita maxima L.) were conducted in the solution-plant microcosms. FOSA was readily taken up by soybean and pumpkin roots and translocated to shoots, and metabolized to PFOS, perfluorohexane sulfonate (PFHxS) and perfluorobutane sulfonate (PFBS)...
June 20, 2018: Ecotoxicology and Environmental Safety
Maitrayee Sardar Sinha, Anna Ansell-Schultz, Livia Civitelli, Camilla Hildesjö, Max Larsson, Lars Lannfelt, Martin Ingelsson, Martin Hallbeck
The gradual deterioration of cognitive functions in Alzheimer's disease is paralleled by a hierarchical progression of amyloid-beta and tau brain pathology. Recent findings indicate that toxic oligomers of amyloid-beta may cause propagation of pathology in a prion-like manner, although the underlying mechanisms are incompletely understood. Here we show that small extracellular vesicles, exosomes, from Alzheimer patients' brains contain increased levels of amyloid-beta oligomers and can act as vehicles for the neuron-to-neuron transfer of such toxic species in recipient neurons in culture...
July 2018: Acta Neuropathologica
Sarah Ettinger, Michael Schwarze, Daiwei Yao, Max Ettinger, Leif Claassen, Christina Stukenborg-Colsman, Hajo Thermann, Christian Plaass
BACKGROUND: With ankle arthritis often affecting young patients, joint-sparing treatments instead of total joint replacement should be considered. Only a few implants were specially developed for supramalleolar osteotomies (SMOT). This study was performed to analyse the stability of different implants and their appropriateness for SMOT. METHODS: Twenty-five bone models (Sawbone Europe, Malmö, Sweden) were used for biomechanical testing. SMOT were performed as a uniplanar osteotomy, leaving 5 mm of lateral bone intact with a standardized gap of 8 mm...
June 22, 2018: Archives of Orthopaedic and Trauma Surgery
Max Masthoff, Sandra Gran, Xueli Zhang, Lydia Wachsmuth, Michael Bietenbeck, Anne Helfen, Walter Heindel, Lydia Sorokin, Johannes Roth, Michel Eisenblätter, Moritz Wildgruber, Cornelius Faber
Time-lapse MRI was implemented for dynamic non-invasive cell tracking of individual slowly moving intravascular immune cells. Repetitive MRI acquisition enabled dynamic observation of iron oxide nanoparticle (ION) labelled cells. Simulations of MRI contrast indicated that only cells moving slower than 1 µm/s were detectable. Time-lapse MRI of the brain was performed after either IONs or ION-labelled monocytes were injected intravenously into naïve and experimental autoimmune encephalomyelitis (EAE) bearing mice at a presymptomatic or symptomatic stage...
June 22, 2018: Scientific Reports
Thiago Augusto Almeida, Edna Afonso Reis, Isabela Vaz Leite Pinto, Maria das Graças Braga Ceccato, Micheline Rosa Silveira, Marina Guimarães Lima, Adriano Max Moreira Reis
BACKGROUND: Potentially inappropriate medications (PIM) for the older adults are those with an unfavorable risk-benefit ratio when more effective and safe therapeutic alternatives are available and is an important public health problem. PURPOSE: To analyze the factors associated with the use of PIM by the older adults and to investigate the agreement of PIM use frequency using the 2015 American Geriatric Society Beers Criteria for Potentially Inappropriate Medication Use in Older Adults - 2015 AGS Beers Criteria, the Brazilian consensus on potentially inappropriate medication for older adults (BCPIM) and the European union list of potentially inappropriate medications - EU (7)-PIM List...
June 15, 2018: Research in Social & Administrative Pharmacy: RSAP
Shareena Bibi, P Rasmussen, P McLiesh
BACKGROUND: Nurses are involved in delivering care for patients following acute traumatic spinal cord injury throughout the entire care journey. An injury of this type is significant for the individual and their family and can be challenging for nurses delivering care for patients with life changing injuries, especially for nurses new to this setting. There is a lack of research that examines the experience of nurses caring for these patients in the acute setting. METHOD: A hermeneutic phenomenological approach was used to understand the experience of nurses caring for patients in the acute setting who had sustained a traumatic spinal injury with associated neurological deficit...
May 15, 2018: International Journal of Orthopaedic and Trauma Nursing
Matteo Zago, Fabio Esposito, Giulia Rausa, Eloisa Limonta, Felice Corrado, Susanna Rampichini, Chiarella Sforza
Changes of direction (CoDs) have a high metabolic and mechanical impact in field and court team sports, but the estimation of the associated workload is still inaccurate. This study aims at validating an algorithm based on kinematic data to estimate the energy cost of running with frequent 180°-CoDs. Twenty-six physically active male subjects (22.4 ± 3.2 years) participated in two sessions: (1) maximum oxygen uptake (V̇O2,max ) and maximal aerobic speed (MAS) test; (2) 5-m continuous shuttle run (two 5-min trials at 50% and 75% MAS, 6-min recovery)...
June 15, 2018: Journal of Biomechanics
Ruihua Wang, Xiongwu Xiao, Bingxuan Guo, Qianqing Qin, Ruizhi Chen
Unmanned aerial vehicles (UAVs) are an inexpensive platform for collecting remote sensing images, but UAV images suffer from a content loss problem caused by noise. In order to solve the noise problem of UAV images, we propose a new methods to denoise UAV images. This paper introduces a novel deep neural network method based on generative adversarial learning to trace the mapping relationship between noisy and clean images. In our approach, perceptual reconstruction loss is used to establish a loss equation that continuously optimizes a min-max game theoretic model to obtain better UAV image denoising results...
June 21, 2018: Sensors
Orgest Lajthia, Jerry W Chao, Max Mandelbaum, John S Myseros, Chima Oluigbo, Suresh N Magge, Christopher S Zarella, Albert K Oh, Gary F Rogers, Robert F Keating
OBJECTIVE Intracranial empyema is a life-threatening condition associated with a high mortality rate and residual deleterious neurological effects if not diagnosed and managed promptly. The authors present their institutional experience with immediate reimplantation of the craniotomy flap and clarify the success of this method in terms of cranial integrity, risk of recurrent infection, and need for secondary procedures. METHODS A retrospective analysis of patients admitted for management of intracranial empyema during a 19-year period (1997-2016) identified 33 patients who underwent emergency drainage and decompression with a follow-up duration longer than 6 months, 23 of whom received immediate bone replacement...
June 22, 2018: Journal of Neurosurgery. Pediatrics
Max Willistein, Julian Haas, Jonathan Fuchs, Sebastian Estelmann, Sascha Ferlaino, Michael Müller, Steffen Lüdeke, Matthias Boll
Birch reductions of aromatic hydrocarbons via single electron transfer steps depend on alkali metals, ammonia, and cryogenic reactions conditions. In contrast, 2 naphthoyl coenzyme A (2 NCoA) and 5,6 dihydro 2 NCoA (5,6 DHNCoA) reductases catalyze two two-electron reductions of the naphthoyl-ring system to tetrahydronaphthoyl-CoA at ambient temperature. Using a number of substrate analogues, we provide evidence for a Meisenheimer complex analogous intermediate during 2-NCoA reduction, while the subsequent reduction of 5,6 dihydro 2 NCoA is suggested to proceed via an unprecedented cationic transition state...
June 22, 2018: Chemistry: a European Journal
Jiwook Ryu, Sung Ho Lee, Seok Keun Choi, Young Jin Lim
PURPOSE: This study evaluated the long-term tumor control rate (TCR) and symptomatic outcomes of patients treated with gamma knife radiosurgery (GKRS) for trigeminal schwannomas (TSs). METHODS: Thirty-two patients with TS who underwent GKRS between January 1994 and January 2013 with at least 2 years of follow-up were enrolled in the study. Clinical charts and surgical records were retrospectively reviewed to evaluate factors affecting TCR and symptomatic outcomes...
June 21, 2018: Journal of Neuro-oncology
Ömrüm Aydin, Max Nieuwdorp, Victor Gerdes
PURPOSE OF REVIEW: The objective of this review is to critically assess the contributing role of the gut microbiota in human obesity and type 2 diabetes (T2D). RECENT FINDINGS: Experiments in animal and human studies have produced growing evidence for the causality of the gut microbiome in developing obesity and T2D. The introduction of high-throughput sequencing technologies has provided novel insight into the interpersonal differences in microbiome composition and function...
June 21, 2018: Current Diabetes Reports
Peter C Revenaugh, Ryan M Smith, Max A Plitt, Lisa Ishii, Kofi Boahene, Patrick J Byrne
Importance: Facial nerve deficits cause significant functional and social consequences for those affected. Existing techniques for dynamic restoration of facial nerve function are imperfect and result in a wide variety of outcomes. Currently, there is no standard objective instrument for facial movement as it relates to restorative techniques. Objective: To determine what objective instruments of midface movement are used in outcome measurements for patients treated with dynamic methods for facial paralysis...
June 21, 2018: JAMA Facial Plastic Surgery
Mark Johnson, Roxanne C Jewell, Amanda Peppercorn, Elizabeth Gould, Jianfeng Xu, Yu Lou, Matthew Davies, Sandra Baldwin, Allan R Tenorio, Matthew Burke, Jerry Jeffrey, Brian A Johns
This work aimed to assess the safety, tolerability, pharmacokinetics (PK), and relative bioavailability of GSK2838232, an investigational HIV maturation inhibitor. GSK2838232 was administered over four dose-escalation studies in healthy subjects which assessed single oral doses (5-250 mg) and repeat doses (up to 200 mg once or twice daily) ±100 mg ritonavir (RTV) once daily. GSK2838232 administration (up to 250 mg) to 124 subjects across four studies resulted in few mild adverse events (AEs) with similar frequencies to placebo...
July 2018: Pharmacology Research & Perspectives
Hongso Yang, Chan Park, Jin-Ho Shin, Kwi-Dug Yun, Hyun-Pil Lim, Sang-Won Park, Hyunju Chung
PURPOSE: To analyze stress distribution in premolars restored with inlays or onlays using various materials. MATERIALS AND METHODS: Three-dimensional maxillary premolar models of abutments were designed to include the following: 1) inlay with O cavity (O group), 2) inlay with MO cavity (MO group), 3) inlay with MOD cavity (MOD group), and 4) onlay (ONLAY group). A restoration of each inlay or onlay cavity was simulated using gold alloy, e.max ceramic, or composite resin for restoration...
June 2018: Journal of Advanced Prosthodontics
Katsuhiko Kohara, Yasuharu Tabara, Masayuki Ochi, Yoko Okada, Maya Ohara, Tokihisa Nagai, Yasumasa Ohyagi, Michiya Igase
Favorable effects of sauna bathing on cardiovascular disease have been demonstrated. Hot water bathing is an alternative, and could also have similar effects. Information pertaining to hot water bathing frequency and water temperature was obtained from 873 subjects. Carotid mean and max intima-media thickness (IMT) and brachial-ankle pulse wave velocity (baPWV) were measured as indices of atherosclerosis. Central haemodynamics were evaluated using radial pulse waveform analyses. Plasma levels of B-type natriuretic peptide (BNP) were measured as an index for cardiac loading...
June 21, 2018: Scientific Reports
Bing Liu, Max Heckler, Ulrike Heger, Susanne Roth, Ulla Klaiber, Markus W Büchler, Oliver Strobel, Christoph W Michalski, Thilo Hackert
BACKGROUND: The number of lymph nodes to be resected in surgery for non-pancreatic periampullary cancer remains unclear. METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was used to gather information from a large retrospective cohort. To define a novel, reasonable cut-off associated with survival, we stratified patients into subgroups depending on the number of resected lymph nodes. RESULTS: 1481 nodal-negative patients resected for periampullary cancer (excluding pancreatic ductal adenocarcinoma) were included...
June 19, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Zhenhua Song, Yan Liu, Rong Song, Zhenguang Chen, Jianyong Yang, Chao Zhang, Qing Jiang
A novel sparsity-based stochastic pooling which integrates the advantages of max-pooling, average-pooling and stochastic pooling is introduced. The proposed pooling is designed to balance the advantages and disadvantages of max-pooling and average-pooling by using the degree of sparsity of activations and a control function to obtain an optimized representative feature value ranging from average value to maximum value of a pooling region. The optimized representative feature value is employed for probability weights assignment of activations in normal distribution...
June 15, 2018: Neural Networks: the Official Journal of the International Neural Network Society
Dilmurodjon Eshmuminov, Filippo Leoni, Marcel André Schneider, Dustin Becker, Xavier Muller, Christopher Onder, Max Hefti, Martin Schuler, Philipp Dutkowski, Rolf Graf, Philipp Rudolf von Rohr, Pierre-Alain Clavien, Lucia Bautista Borrego
Liver machine perfusion at normothermic temperature (NMP) is a promising way to preserve and evaluate extended criteria donor livers. Currently, no consensus exists in methodology and perfusion protocols. Here, the authors performed a systematic literature search to identify human and porcine studies reporting on liver NMP with red blood cells. A qualitative synthesis was performed concerning technical aspects of machine perfusion, fluid composition, gas supply and liver positioning. 37 publications including 11 human and 26 porcine studies were considered for qualitative synthesis...
June 21, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
Jung Sunwoo, Yu Kyong Kim, Yewon Choi, Kyung-Sang Yu, Heesook Nam, Young Lag Cho, Seonghae Yoon, Jae-Yong Chung
Background: LCB01-0371 is a novel oxazolidinone antibiotic that blocks protein production by binding to bacterial 23S ribosomes. This antibiotic is active against Gram-positive bacteria. This study aimed to evaluate the effect of food on the pharmacokinetics (PKs) of LCB01-0371 and evaluate its safety profile. Subjects and methods: A randomized, open-label, two-way crossover study was performed in 18 healthy Korean male subjects. All subjects received a single oral 800 mg dose of LCB01-0371 in each period under fed or fasting condition with a 7-day washout in between...
2018: Drug Design, Development and Therapy
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