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https://www.readbyqxmd.com/read/28346900/growing-season-variability-in-carbon-dioxide-exchange-of-irrigated-and-rainfed-soybean-in-the-southern-united-states
#1
Pradeep Wagle, Prasanna H Gowda, Saseendran S Anapalli, Krishna N Reddy, Brian K Northup
Measurement of carbon dynamics of soybean (Glycine max L.) ecosystems outside Corn Belt of the United States (U.S.) is lacking. This study examines the seasonal variability of net ecosystem CO2 exchange (NEE) and its components (gross primary production, GPP and ecosystem respiration, ER), and relevant controlling environmental factors between rainfed (El Reno, Oklahoma) and irrigated (Stoneville, Mississippi) soybean fields in the southern U.S. during the 2016 growing season. Grain yield was about 1.6tha(-1) for rainfed soybean and 4...
March 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28346286/delayed-coronary-obstruction-following-portico-in-freedom-solo-valve-in-valve-implantation
#2
Johannes Kastner, Georg Goliasch, Max-Paul Winter, Olev Luha, Martin Andreas, Irene M Lang
No abstract text is available yet for this article.
March 24, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28346257/dermal-piercing-removal-searching-for-an-optimal-technique
#3
Aubrey E Winn, Shayna C Rivard, Max L Gratrix
No abstract text is available yet for this article.
March 23, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28346153/national-sleep-foundation-s-sleep-quality-recommendations-first-report
#4
Maurice Ohayon, Emerson M Wickwire, Max Hirshkowitz, Steven M Albert, Alon Avidan, Frank J Daly, Yves Dauvilliers, Raffaele Ferri, Constance Fung, David Gozal, Nancy Hazen, Andrew Krystal, Kenneth Lichstein, Monica Mallampalli, Giuseppe Plazzi, Robert Rawding, Frank A Scheer, Virend Somers, Michael V Vitiello
OBJECTIVES: To provide evidence-based recommendations and guidance to the public regarding indicators of good sleep quality across the life-span. METHODS: The National Sleep Foundation assembled a panel of experts from the sleep community and representatives appointed by stakeholder organizations (Sleep Quality Consensus Panel). A systematic literature review identified 277 studies meeting inclusion criteria. Abstracts and full-text articles were provided to the panelists for review and discussion...
February 2017: Sleep Health
https://www.readbyqxmd.com/read/28345900/fluorescence-and-radio-labeling-of-lys-4-nle-17-30-hpp-yields-molecular-tools-for-the-npy-y4-receptor
#5
Stefanie Dukorn, Timo Littmann, Max Keller, Kilian Konrad Kuhn, Chiara Cabrele, Paul Baumeister, Günther Bernhardt, Armin Buschauer
The neuropeptide Y (NPY) Y4 receptor (Y4R) is involved in energy homeostasis and considered as a potential drug target for the treatment of obesity. Only a few molecular tools, i. e., radiolabeled and fluorescent ligands, for the investigation of the Y4R were reported. Previously, [Lys(4)]hPP proved to be an appropriate full-length PP analog to prepare a fluorescent ligand by derivatization at the ε-amino group. To preclude oxidation upon long-term storage, we replaced the two methionine residues in [Lys(4)]hPP by norleucine and prepared the corresponding [(3)H]propionylated ([(3)H]12) and cyanine labeled (13) peptides, which were characterized and compared with a set of reference compounds in binding (Y1, Y2, Y4 and Y5 receptors) and functional (luciferase gene reporter, β-arrestin-1, -2) Y4R assays...
March 27, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28345654/the-soybean-gmsnap18-gene-underlies-two-types-of-resistance-to-soybean-cyst-nematode
#6
Shiming Liu, Pramod K Kandoth, Naoufal Lakhssassi, Jingwen Kang, Vincent Colantonio, Robert Heinz, Greg Yeckel, Zhou Zhou, Sadia Bekal, Johannes Dapprich, Bjorn Rotter, Silvia Cianzio, Melissa G Mitchum, Khalid Meksem
Two types of resistant soybean (Glycine max (L.) Merr.) sources are widely used against soybean cyst nematode (SCN, Heterodera glycines Ichinohe). These include Peking-type soybean, whose resistance requires both the rhg1-a and Rhg4 alleles, and PI 88788-type soybean, whose resistance requires only the rhg1-b allele. Multiple copy number of PI 88788-type GmSNAP18, GmAAT, and GmWI12 in one genomic segment simultaneously contribute to rhg1-b resistance. Using an integrated set of genetic and genomic approaches, we demonstrate that the rhg1-a Peking-type GmSNAP18 is sufficient for resistance to SCN in combination with Rhg4...
March 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28345304/chemical-evidence-for-the-effect-of-urochloa-ruziziensis-on-glyphosate-resistant-soybeans
#7
Mariluce Nepomuceno, Nuria Chinchilla, Rosa M Varela, José M G Molinillo, Rodney Lacret, Pedro L C A Alves, Francisco A Macias
BACKGROUND: Soybean (Glycine max) is an important oleaginous legume that has been cultivated in new areas in Brazil, including pastures. Problems of reduced production yields have been reported by soybean growers when the crop is sown immediately after desiccation of pastures of Urochloa spp. using glyphosate. The objective of this work was to extract, isolate, and identify the major chemicals from U. ruziziensis that have phytotoxic activity and to evaluate the possible relation between this effect and the reduced soybean yield...
March 26, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28345260/resistance-and-aerobic-training-improve-muscle-strength-and-aerobic-capacity-in-cidp
#8
Lars H Markvardsen, Kristian Overgaard, Karen Heje, Søren H Sindrup, Ingelise Christiansen, John Vissing, Henning Andersen
INTRODUCTION: We investigated the effect of aerobic and resistance exercise in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). METHODS: Eighteen CIDP patients treated with subcutaneous immunoglobulin did 12 weeks of aerobic exercise and 12 weeks of resistance exercise after a run-in period of 12 weeks without exercise. Three times weekly the participants performed aerobic exercise on an ergometer bike or resistance exercise with unilateral training of knee and elbow flexion/extension...
March 27, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28345249/a-multinational-drug-utilisation-study-to-investigate-the-use-of-dexmedetomidine-dexdor%C3%A2-in-clinical-practice-in-the-eu
#9
M Weatherall, R Aantaa, G Conti, C J Garratt, P Pohjanjousi, M A Lewis, N Moore, S Perez-Gutthann
AIMS: Dexmedetomidine (dexdor®) is approved in the EU for sedation of adults in the ICU. This observational, retrospective study was requested by the European Medicines Agency to investigate dexmedetomidine use in clinical practice, with particular focus on off-label use including the paediatric population. METHODS: Study countries and sites were chosen from those with highest dexmedetomidine use, based on sales. Site selection (blind) was conducted by a multi-specialist, independent group...
March 27, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28345217/fatigue-and-training-of-obstetrics-and-gynaecology-trainees-in-australia-and-new-zealand
#10
Paige E Tucker, Paul A Cohen, Max K Bulsara, Jade Acton
BACKGROUND: Several studies have linked doctor fatigue with adverse patient events and an increase in risk to doctors' personal safety and wellbeing. The present study assesses the rostering structure of Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG) trainees and its association with trainees' reported fatigue levels, training opportunities and wellbeing, which were secondary outcomes of a larger study of trainee working hours which has been separately reported...
March 26, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28345164/comparing-functional-mri-protocols-for-small-iron-rich-basal-ganglia-nuclei-such-as-the-subthalamic-nucleus-at-7-t-and-3-t
#11
Gilles de Hollander, Max C Keuken, Wietske van der Zwaag, Birte U Forstmann, Robert Trampel
The basal ganglia (BG) form a network of subcortical nuclei. Functional magnetic resonance imaging (fMRI) in the BG could provide insight in its functioning and the underlying mechanisms of Deep Brain Stimulation (DBS). However, fMRI of the BG with high specificity is challenging, because the nuclei are small and variable in their anatomical location. High resolution fMRI at field strengths of 7 Tesla (T) could help resolve these challenges to some extent. A set of MR protocols was developed for functional imaging of the BG nuclei at 3 T and 7 T...
March 27, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28345163/pharmacokinetics-and-safety-of-letermovir-a-novel-anti-human-cytomegalovirus-drug-in-patients-with-renal-impairment
#12
D Kropeit, J Scheuenpflug, K Erb-Zohar, A Halabi, H-P Stobernack, E G J Hulskotte, A van Schanke, H Zimmermann, H Rübsamen-Schaeff
AIMS: Human cytomegalovirus remains a significant issue for immunocompromised patients and existing viral polymerase targeting therapies are associated with significant toxicity. Accordingly, the viral terminase complex inhibitor, letermovir, is in development. We assessed letermovir pharmacokinetics in renal impairment. METHODS: This was a Phase 1, open-label, non-randomised trial. Estimated glomerular filtration rate (eGFR) based on the Modification of Diet Renal Disease equation was used to create 3 groups of 8 subjects: healthy function (eGFR ≥90 mL/min/1...
March 26, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28345074/single-cell-rna-seq-and-computational-analysis-using-temporal-mixture-modelling-resolves-th1-tfh-fate-bifurcation-in-malaria
#13
Tapio Lönnberg, Valentine Svensson, Kylie R James, Daniel Fernandez-Ruiz, Ismail Sebina, Ruddy Montandon, Megan S F Soon, Lily G Fogg, Arya Sheela Nair, Urijah Liligeto, Michael J T Stubbington, Lam-Ha Ly, Frederik Otzen Bagger, Max Zwiessele, Neil D Lawrence, Fernando Souza-Fonseca-Guimaraes, Patrick T Bunn, Christian R Engwerda, William R Heath, Oliver Billker, Oliver Stegle, Ashraful Haque, Sarah A Teichmann
Differentiation of naïve CD4(+) T cells into functionally distinct T helper subsets is crucial for the orchestration of immune responses. Due to extensive heterogeneity and multiple overlapping transcriptional programs in differentiating T cell populations, this process has remained a challenge for systematic dissection in vivo. By using single-cell transcriptomics and computational analysis using a temporal mixtures of Gaussian processes model, termed GPfates, we reconstructed the developmental trajectories of Th1 and Tfh cells during blood-stage Plasmodium infection in mice...
March 3, 2017: Science Immunology
https://www.readbyqxmd.com/read/28343087/cad-cam-machining-vs-pre-sintering-in-lab-fabrication-techniques-of-y-tzp-ceramic-specimens-effects-on-their-mechanical-fatigue-behavior
#14
C P Zucuni, L F Guilardi, S Fraga, L G May, G K R Pereira, L F Valandro
This study evaluated the effects of different pre-sintering fabrication processing techniques of Y-TZP ceramic (CAD/CAM Vs. in-lab), considering surface characteristics and mechanical performance outcomes. Pre-sintered discs of Y-TZP ceramic (IPS e.max ZirCAD, Ivoclar Vivadent) were produced using different pre-sintering fabrication processing techniques: Machined- milling with a CAD/CAM system; Polished- fabrication using a cutting device followed by polishing (600 and 1200 SiC papers); Xfine- fabrication using a cutting machine followed by grinding with extra-fine diamond bur (grit size 30 μm); Fine- fabrication using a cutting machine followed by grinding with fine diamond bur (grit size 46 μm); SiC- fabrication using a cutting machine followed by grinding with 220 SiC paper...
March 18, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28342833/a-high-density-cho-s-transient-transfection-system-comparison-of-expicho-and-expi293
#15
Nina K Jain, Susan Barkowski-Clark, Richard Altman, Krista Johnson, Fang Sun, Jonathan Zmuda, Chao Yan Liu, Adriana Kita, Ryan Schulz, Alyssa Neill, Robert Ballinger, Rekha Patel, Jian Liu, Alinafe Mpanda, Brian Huta, Henry Chiou, Walter Voegtli, Tadas Panavas
Chinese Hamster Ovary (CHO) cells are the principal mammalian host used for stable cell line generation and biotherapeutic protein production. Until recently, production of milligrams to grams of protein in CHO transient systems was challenging. As such, Human Embryonic Kidney (HEK293) cells are the most common mammalian cell type used for transient transfection. The post-translational modifications (PTMs) of a protein are dictated in part by the cell line used for expression, and changes in PTMs have been shown to affect both the activity and biophysical properties of proteins...
March 22, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/28342811/myeloid-sarcoma-presentation-diagnosis-and-treatment
#16
REVIEW
L Max Almond, Maria Charalampakis, Samuel J Ford, David Gourevitch, Anant Desai
Myeloid sarcoma is an extramedullary tumor of immature granulocytic cells. It is a rare condition, most often associated with acute myeloid leukemia (AML), although in some rare cases it may present in nonleukemic patients. It should therefore be considered as a differential diagnosis of any atypical cellular infiltrate. It may occur at any site, leading to very varied clinical presentations. Diagnosis is challenging and relies on a high index of suspicion as well as radiology, histology, immunophenotyping, and molecular analyses, which also are essential for risk stratification and treatment planning...
March 7, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28342761/cardiovascular-tolerance-of-intravenous-bupivacaine-in-broiler-chickens-gallus-gallus-domesticus-anesthetized-with-isoflurane
#17
Peter M DiGeronimo, Anderson F da Cunha, Bruno Pypendop, João Brandão, Rhett Stout, Max Rinaldi, Thomas N Tully
OBJECTIVE: To determine the median effective dose (ED50) of intravenous (IV) bupivacaine associated with a 50% probability of causing clinically relevant cardiovascular effects [defined as 30% change in heart rate (HR) or mean arterial pressure (MAP)] in chickens anesthetized with isoflurane. STUDY DESIGN: Randomized up-and-down study. ANIMALS: A total of 14 Ross-708 broiler chickens (Gallus gallus domesticus) weighing 1.70-2.75 kg. METHODS: Anesthesia was induced and maintained with isoflurane...
January 11, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28342659/urologic-oncologic-surveyrobotic-level-iii-inferior-vena-cava-tumor-thrombectomy-initial-series-gill-is-metcalfe-c-abreu-a-duddalwar-v-chopra-s-cunningham-m-thangathurai-d-ukimura-o-satkunasivam-r-hung-a-papalia-r-aron-m-desai-m-gallucci-m-j-urol-2015-oct-194
#18
Max Meng
PURPOSE: Level III inferior vena cava tumor thrombectomy for renal cancer is one of the most challenging open urologic surgeries. We present the initial series of completely intracorporeal robotic level III inferior vena cava tumor thrombectomy. MATERIALS AND METHODS: Nine patients underwent robotic level III inferior vena cava thrombectomy and 7 patients underwent level II thrombectomy. The entire operation (high intrahepatic inferior vena cava control, caval exclusion, tumor thrombectomy, inferior vena cava repair, radical nephrectomy, and retroperitoneal lymphadenectomy) was performed exclusively robotically...
March 22, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28342120/the-impact-of-hepaticojejunostomy-leaks-after-pancreatoduodenectomy-a-devastating-source-of-morbidity-and-mortality
#19
Andrea L Jester, Catherine W Chung, David C Becerra, E Molly Kilbane, Michael G House, Nicholas J Zyromski, C Max Schmidt, Attila Nakeeb, Eugene P Ceppa
INTRODUCTION: Hepaticojejunostomy leaks are less frequent than pancreatic leaks after pancreatoduodenectomy, and the current literature suggests comparable outcomes. The purpose of this study was to determine if the hepaticojejunostomy leak adversely affected patient outcomes. METHODS: Consecutive cases of pancreatoduodenectomy (n = 924) were reviewed at a single high-volume institution over an 8-year period (2006-2014). RESULTS: Pancreaticojejunostomy leaks were identified in 217 (23%) patients and hepaticojejunostomy leaks were identified in 24 patients (3%); combined hepaticojejunostomy/pancreaticojejunostomy leaks were identified in 31 patients (3%)...
March 24, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28341959/a-randomized-single-blind-single-dose-study-evaluating-the-pharmacokinetic-equivalence-of-proposed-biosimilar-abp-980-and-trastuzumab-in-healthy-male-subjects
#20
Vladimir Hanes, Vincent Chow, Nan Zhang, Richard Markus
PURPOSE: This study compared the pharmacokinetic (PK) profiles of the proposed biosimilar ABP 980 and trastuzumab in healthy males. METHODS: In this single-blind study, 157 healthy males were randomized 1:1:1 to a single 6 mg/kg intravenous infusion of ABP 980, FDA-licensed trastuzumab [trastuzumab (US)], or EU-authorized trastuzumab [trastuzumab (EU)]. Primary endpoints were area under the serum concentration-time curve from time 0 to infinity (AUCinf) and maximum observed serum concentration (C max)...
March 24, 2017: Cancer Chemotherapy and Pharmacology
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