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https://www.readbyqxmd.com/read/29457974/a-multi-omics-analysis-of-glycine-max-leaves-reveals-alteration-in-flavonoid-and-isoflavonoid-metabolism-upon-ethylene-and-abscisic-acid-treatment
#1
Ravi Gupta, Cheol Woo Min, Katharina Kramer, Ganesh Kumar Agrawal, Randeep Rakwal, Ki-Hun Park, Yiming Wang, Iris Finkemeier, Sun Tae Kim
Phytohormones are central to the plant growth and development. Despite the advancement in our knowledge of hormone signaling, downstream targets and their interactions upon hormones action remain largely fragmented, especially at the protein and metabolite levels. With an aim to get new insight into the effects of two hormones, ethylene (ET) and abscisic acid (ABA), this study utilizes an integrated proteomics and metabolomics approach to investigate their individual and combined (ABA+ET) signaling in soybean leaves...
February 19, 2018: Proteomics
https://www.readbyqxmd.com/read/29457862/peter-j-dunn-award-international-solvay-chair-in-chemistry-for-gernot-frenking-max-born-prize-for-angel-rubio-terrae-rarae-prize-for-rhett-kempe-frontiers-in-chemical-energy-science-award-for-karsten-reuter-and-also-in-the-news
#2
https://www.readbyqxmd.com/read/29457704/comparability-and-repeatability-of-three-commonly-used-methods-for-measuring-endurance-capacity
#3
James Baxter-Gilbert, Max Mühlenhaupt, Martin J Whiting
Measures of endurance (time to exhaustion) have been used to address a wide range of questions in ecomorphological and physiological research, as well as being used as a proxy for survival and fitness. Swimming, stationary (circular) track running, and treadmill running are all commonly used methods for measuring endurance. Despite the use of these methods across a broad range of taxa, how comparable these methods are to one another, and whether they are biologically relevant, is rarely examined. We used Australian water dragons (Intellagama lesueurii), a species that is morphologically adept at climbing, swimming, and running, to compare these three methods of endurance and examined if there is repeatability within and between trial methods...
February 19, 2018: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29457531/shedding-new-light-on-rhoa-signalling-as-a-drug-target-in-vivo-using-a-novel-rhoa-fret-biosensor-mouse
#4
Max Nobis, David Herrmann, Sean C Warren, Douglas Strathdee, Thomas R Cox, Kurt I Anderson, Paul Timpson
The small GTPase RhoA is a master regulator of signalling in cell-extracellular matrix interactions. RhoA signalling is critical to many cellular processes including migration, mechanotransduction, and is often disrupted in carcinogenesis. Investigating RhoA activity in a native tissue environment is challenging using conventional biochemical methods; we therefore developed a RhoA-FRET biosensor mouse, employing the adaptable nature of intravital imaging to a variety of settings. Mechnotransduction was explored in the context of osteocyte processes embedded in the calvaria responding in a directional manner to compression stress...
February 18, 2018: Small GTPases
https://www.readbyqxmd.com/read/29457381/a-multicentre-study-of-validity-and-reliability-of-responses-to-hand-cold-challenge-as-measured-by-laser-speckle-contrast-imaging-and-thermography-outcome-measures-for-systemic-sclerosis-related-raynaud-s-phenomenon
#5
Jack D Wilkinson, Sarah A Leggett, Elizabeth J Marjanovic, Tonia L Moore, John Allen, Marina E Anderson, Jason Britton, Maya H Buch, Francesco Del Galdo, Christopher P Denton, Graham Dinsdale, Bridgett Griffiths, Frances Hall, Kevin Howell, Audrey MacDonald, Neil J McHugh, Joanne B Manning, John D Pauling, Christopher Roberts, Jacqueline A Shipley, Ariane L Herrick, Andrea K Murray
BACKGROUND: Objective and reliable outcome measures to facilitate clinical trials of novel treatments for systemic sclerosis (SSc)-related Raynaud's phenomenon (RP) are badly needed. Laser speckle contrast imaging (LSCI) and thermography are non-invasive measures of perfusion that show excellent potential. The purpose of this multi-centre study was to determine the reliability and validity of a hand cold challenge protocol using LSCI, standard thermography and low-cost mobile phone-based thermography...
February 18, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29457311/bicuspid-axial-wall-height-effect-on-cad-cam-crown-fracture-mode-on-preparations-containing-advanced-total-occlusal-convergence
#6
Matthew Miller, Nicholas DuVall, John Brewster, Michael N Wajdowicz, Ashley Harris, Howard W Roberts
PURPOSE: To evaluate bicuspid axial wall height effect on the fracture mode of adhesively luted, all-ceramic CAD/CAM crowns with a 20° total occlusal convergence (TOC). MATERIALS AND METHODS: Recently extracted premolars were randomly divided into 4 groups (n = 12) with all-ceramic crown preparations accomplished using a high-speed handpiece inserted into a milling device. Specimens were prepared containing occlusogingival axial wall heights of 3, 2, and 1 mm as well as a group containing a flat preparation surface with no axial wall height...
February 18, 2018: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29457276/abrus-agglutinin-stimulates-bmp-2-dependent-differentiation-through-autophagic-degradation-of-%C3%AE-catenin-in-colon-cancer-stem-cells
#7
Prashanta Kumar Panda, Prajna Paramita Naik, Prakash P Praharaj, Biswa Ranjan Meher, Piyush Kumar Gupta, Rama S Verma, Tapas K Maiti, Muthu K Shanmugam, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Gautam Sethi, Rajesh Agarwal, Sujit K Bhutia
Eradicating cancer stem cells (CSCs) in colorectal cancer (CRC) through differentiation therapy is a promising approach for cancer treatment. Our retrospective tumor-specimen analysis elucidated alteration in the expression of bone morphogenetic protein 2 (BMP-2) and β-catenin during the colon cancer progression, indicating that their possible intervention through "forced differentiation" in colon cancer remission. We reveal that Abrus agglutinin (AGG) induces the colon CSCs differentiation, enhancing sensitive to the anticancer therapeutics...
February 19, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29457226/coordination-and-trade-offs-among-hydraulic-safety-efficiency-and-drought-avoidance-traits-in-amazonian-rainforest-canopy-tree-species
#8
Louis S Santiago, Mark E De Guzman, Christopher Baraloto, Jacob E Vogenberg, Max Brodie, Bruno Hérault, Claire Fortunel, Damien Bonal
Predicting responses of tropical forests to climate change-type drought is challenging because of high species diversity. Detailed characterization of tropical tree hydraulic physiology is necessary to evaluate community drought vulnerability and improve model parameterization. Here, we measured xylem hydraulic conductivity (hydraulic efficiency), xylem vulnerability curves (hydraulic safety), sapwood pressure-volume curves (drought avoidance) and wood density on emergent branches of 14 common species of Eastern Amazonian canopy trees in Paracou, French Guiana across species with the densest and lightest wood in the plot...
February 19, 2018: New Phytologist
https://www.readbyqxmd.com/read/29456986/extract-from-teucrium-polium-l-protects-rat-heart-against-oxidative-stress-induced-by-ischemic-reperfusion-injury
#9
Maryam Mahmoudabady, Milad Haghshenas, Saeed Niazmand
Background: The deleterious effect of oxidative stress on myocardial ischemia-reperfusion (I/R) has already been shown in previous studies. Since Teucrium polium has anti-oxidative and cardio-protective properties, the aim of this study was to investigate the effects of this plant on I/R injuries in the isolated rat heart. Materials and Methods: The myocardial I/R injury of rat was created by Langendorff retrograde perfusion technology. The heart was preperfused with Krebs-Henseleit (K-H) solution containing T...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29456467/clinical-approaches-to-breast-reconstruction-what-is-the-appropriate-reconstructive-procedure-for-my-patient
#10
REVIEW
Max Dieterich, Adrian Dragu, Angrit Stachs, Johannes Stubert
Breast reconstruction after breast cancer is an emotional subject for women. Consequently, the correct timing and surgical procedure for each individual woman are important. In general, heterologous or autologous reconstructive procedures are available, both having advantages and disadvantages. Breast size, patient habitus, and previous surgeries or radiation therapy need to be considered, independent of the chosen procedure. New surgical techniques, refinement of surgical procedures, and the development of supportive materials have increased the general patient collective eligible for breast reconstruction...
December 2017: Breast Care
https://www.readbyqxmd.com/read/29456420/timely-news-for-the-multidisciplinary-care-team
#11
Max Bingham
Welcome to Diabetes Spectrum 's first installment of Diabetes is Primary, a round-up of the latest diabetes developments for health care providers. In this issue, we take a look at radical weight loss for diabetes remission, Hong Kong's diabetes risk assessment and management program, personalized A1C targets, and diabetes diagnoses. The American Diabetes Association (ADA) and European Association for the Study of Diabetes (EASD) panel gives its verdict on continuous glucose monitoring (CGM) devices, and we learn how Medicare will soon pay for a diabetes prevention program...
February 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29456189/programmable-rna-cleavage-and-recognition-by-a-natural-crispr-cas9-system-from-neisseria-meningitidis
#12
Beth A Rousseau, Zhonggang Hou, Max J Gramelspacher, Yan Zhang
The microbial CRISPR systems enable adaptive defense against mobile elements and also provide formidable tools for genome engineering. The Cas9 proteins are type II CRISPR-associated, RNA-guided DNA endonucleases that identify double-stranded DNA targets by sequence complementarity and protospacer adjacent motif (PAM) recognition. Here we report that the type II-C CRISPR-Cas9 from Neisseria meningitidis (Nme) is capable of programmable, RNA-guided, site-specific cleavage and recognition of single-stranded RNA targets and that this ribonuclease activity is independent of the PAM sequence...
February 14, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29456144/global-demand-for-natural-resources-eliminated-more-than-100-000-bornean-orangutans
#13
Maria Voigt, Serge A Wich, Marc Ancrenaz, Erik Meijaard, Nicola Abram, Graham L Banes, Gail Campbell-Smith, Laura J d'Arcy, Roberto A Delgado, Andi Erman, David Gaveau, Benoit Goossens, Stefanie Heinicke, Max Houghton, Simon J Husson, Ashley Leiman, Karmele Llano Sanchez, Niel Makinuddin, Andrew J Marshall, Ari Meididit, Jukka Miettinen, Roger Mundry, Musnanda, Nardiyono, Anton Nurcahyo, Kisar Odom, Adventus Panda, Didik Prasetyo, Aldrianto Priadjati, Purnomo, Andjar Rafiastanto, Anne E Russon, Truly Santika, Jamartin Sihite, Stephanie Spehar, Matthew Struebig, Enrique Sulbaran-Romero, Albertus Tjiu, Jessie Wells, Kerrie A Wilson, Hjalmar S Kühl
Unsustainable exploitation of natural resources is increasingly affecting the highly biodiverse tropics [1, 2]. Although rapid developments in remote sensing technology have permitted more precise estimates of land-cover change over large spatial scales [3-5], our knowledge about the effects of these changes on wildlife is much more sparse [6, 7]. Here we use field survey data, predictive density distribution modeling, and remote sensing to investigate the impact of resource use and land-use changes on the density distribution of Bornean orangutans (Pongo pygmaeus)...
February 12, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29455948/belief-delusion-hypnosis-and-the-right-dorsolateral-prefrontal-cortex-a-transcranial-magnetic-stimulation-study
#14
Max Coltheart, Rochelle Cox, Paul Sowman, Hannah Morgan, Amanda Barnier, Robyn Langdon, Emily Connaughton, Lina Teichmann, Nikolas Williams, Vince Polito
According to the Two-Factor theory of delusional belief (see e.g. Coltheart at al., 2011), there exists a cognitive system dedicated to the generation, evaluation, and acceptance or rejection of beliefs. Studies of the neuropsychology of delusion provide evidence that this system is neurally realized in right dorsolateral prefrontal cortex (rDLPFC). Furthermore, we have shown that convincing analogues of many specific delusional beliefs can be created in nonclinical subjects by hypnotic suggestion and we think of hypnosis as having the effect of temporarily interfering with the operation of the belief system, which allows acceptance of the delusional suggestions...
January 31, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29455593/acute-compressive-stress-activates-rho-rock-mediated-cellular-processes
#15
Sarah T Boyle, Jasreen Kular, Max Nobis, Andrew Ruszkiewicz, Paul Timpson, Michael S Samuel
The ability to rapidly respond to applied force underpins cell/tissue homeostasis. This response is mediated by mechanotransduction pathways that regulate remodeling and tension of the actomyosin cytoskeleton to counterbalance external forces. Enhanced extracellular matrix tension hyper-activates mechanotransduction and characterizes diseased states such as cancer, but is also required for normal epidermal regeneration. While the impact of extracellular matrix tension on signaling and cell biology are well appreciated, that of acute compressive force is under-studied...
February 17, 2018: Small GTPases
https://www.readbyqxmd.com/read/29455522/all-mxene-based-integrated-electrode-constructed-by-ti3c2-nanoribbon-framework-host-and-nanosheet-interlayer-for-high-energy-density-li-s-batteries
#16
Yanfeng Dong, Shuanghao Zheng, Jieqiong Qin, Xuejun Zhao, Haodong Shi, Xiaohui Wang, Jian Chen, Zhong-Shuai Wu
High-energy-density lithium-sulfur (Li-S) batteries hold promise for next-generation portable electronic devices, but are facing great challenges in rational construction of novel high-performance flexible electrode and innovative cell configuration for actual applications. Here we demonstrated an all-MXene-based flexible and integrated sulfur cathode, enabled by three dimensional alkalized Ti3C2 MXene nanoribbon (a-Ti3C2 MNR) frameworks as S/polysulfides host (a-Ti3C2-S) and two dimensional delaminated Ti3C2 MXene (d-Ti3C2) nanosheets as interlayer on polypropylene (PP) separator, for high-energy and long-cycle Li-S batteries...
February 17, 2018: ACS Nano
https://www.readbyqxmd.com/read/29455064/the-dynamics-of-both-filamentous-and-globular-mammalian-reovirus-viral-factories-rely-on-the-microtubule-network
#17
Catherine Eichwald, Mathias Ackermann, Max L Nibert
Mammalian reovirus viral factories (VFs) form filamentous or globular structures depending on the viral strain. In this study, we attempt to characterize the dynamics of both filamentous and globular VFs. Here, we present evidence demonstrating that globular VFs are dynamic entities coalescing between them, thereby gaining in size and concomitantly decreasing in numbers during the course of the infection. Additionally, both kinds of VFs condense into a perinuclear position. Our results show that globular VFs rely on an intact MT-network for dynamic motion, structural assembly, and maintenance and for perinuclear condensation...
February 15, 2018: Virology
https://www.readbyqxmd.com/read/29454264/development-and-validation-of-uplc-ms-ms-assay-for-quantification-of-cladrin-absolute-bioavailability-and-dose-proportionality-study-in-rats
#18
Mamunur Rashid, Sandeep K Singh, Mohd Yaseen Malik, Sadaf Jahan, Swati Chaturvedi, Isha Taneja, Kanumuri Sivarama Raju, Zaiba Naseem, J R Gayen, Muhammad Wahajuddin
Cladrin, an isoflavone is a major bioactive constituent found in stem bark of Butea monosperma with remarkable osteogenic activity. A speedy and sensitive UPLC coupled tandem mass spectrometry (UPLC-MS/MS) method was developed, validated and successfully applied to bioavailability, blood partitioning, plasma protein binding, intravenous and multiple-dose oral pharmacokinetics of cladrin in rats. Separation was done on C18 column (5.0 μm, 4.6 × 50 mm) using mobile phase containing acetonitrile and 0.10% formic acid in the ratio of 65:35 (v/v) with 0...
January 31, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29454253/charge-transfer-complex-between-2-3-diaminopyridine-with-chloranilic-acid-synthesis-characterization-and-dft-td-dft-computational-studies
#19
Khairia M Al-Ahmary, Moustafa M Habeeb, Areej H Al-Obidan
New charge transfer complex (CTC) between the electron donor 2,3-diaminopyridine (DAP) with the electron acceptor chloranilic (CLA) acid has been synthesized and characterized experimentally and theoretically using a variety of physicochemical techniques. The experimental work included the use of elemental analysis, UV-vis, IR and 1 H NMR studies to characterize the complex. Electronic spectra have been carried out in different hydrogen bonded solvents, methanol (MeOH), acetonitrile (AN) and 1:1 mixture from AN-MeOH...
February 10, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29454202/global-patterns-of-extreme-drought-induced-loss-in-land-primary-production-identifying-ecological-extremes-from-rain-use-efficiency
#20
Ling Du, Nathaniel Mikle, Zhenhua Zou, Yuanyuan Huang, Zheng Shi, Lifen Jiang, Heather R McCarthy, Junyi Liang, Yiqi Luo
Quantifying the ecological patterns of loss of ecosystem function in extreme drought is important to understand the carbon exchange between the land and atmosphere. Rain-use efficiency [RUE; gross primary production (GPP)/precipitation] acts as a typical indicator of ecosystem function. In this study, a novel method based on maximum rain-use efficiency (RUE max ) was developed to detect losses of ecosystem function globally. Three global GPP datasets from the MODIS remote sensing data (MOD17), ground upscaling FLUXNET observations (MPI-BGC), and process-based model simulations (BESS), and a global gridded precipitation product (CRU) were used to develop annual global RUE datasets for 2001-2011...
February 14, 2018: Science of the Total Environment
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