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https://www.readbyqxmd.com/read/28440881/overexpression-of-a-type-i-isopentenyl-pyrophosphate-isomerase-of-artemisia-annua-in-the-cytosol-leads-to-high-arteannuin-b-production-and-artemisinin-increase
#1
Dongming Ma, Gui Li, Fatima Alejos-Gonzalez, Yue Zhu, Zhen Xue, Aimin Wang, Hui Zhang, Xing Li, Hechun Ye, Hong Wang, Benye Liu, De-Yu Xie
We recently characterized a gene-terpene network that is associated with artemisinin biosynthesis in self-pollinated (SP) Artemisia annua, an effective antimalarial plant. We hypothesize that an alteration of gene expression in the network may improve the production of artemisinin and its precursors. In this study, we cloned an isopentenyl pyrophosphate isomerase (IPPI) cDNA, AaIPPI1, from Artemisia annua (Aa). The full-length cDNA encodes a type I IPPI containing a plastid transit peptide (PTP) at its amino terminus...
April 25, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28423593/anti-cancer-effect-of-novel-pak1-inhibitor-via-induction-of-puma-mediated-cell-death-and-p21-mediated-cell-cycle-arrest
#2
Tae-Gyun Woo, Min-Ho Yoon, Shin-Deok Hong, Jiyun Choi, Nam-Chul Ha, Hokeun Sun, Bum-Joon Park
Hyper-activation of PAK1 (p21-activated kinase 1) is frequently observed in human cancer and speculated as a target of novel anti-tumor drug. In previous, we also showed that PAK1 is highly activated in the Smad4-deficient condition and suppresses PUMA (p53 upregulated modulator of apoptosis) through direct binding and phosphorylation. On the basis of this result, we have tried to find novel PAK1-PUMA binding inhibitors. Through ELISA-based blind chemical library screening, we isolated single compound, IPP-14 (IPP; Inhibitor of PAK1-PUMA), which selectively blocks the PAK1-PUMA binding and also suppresses cell proliferation via PUMA-dependent manner...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423214/plasmodium-falciparum-otu-like-cysteine-protease-pfotu-is-essential-for-apicoplast-homeostasis-and-associates-with-non-canonical-role-of-atg8
#3
Gaurav Datta, Mohammad E Hossain, Mohd Asad, Sumit Rathore, Asif Mohmmed
The metabolic pathways associated with the mitochondrion and the apicoplast in Plasmodium, two parasite organelles of prokaryotic origin, are considered as suitable drug targets. In the present study, we have identified functional role of a novel OTU domain containing cysteine protease of Plasmodium falciparum (PfOTU). A C-terminal regulatable fluorescent affinity (RFA) tag on native protein was utilized for its localization and functional characterization. Detailed studies showed vesicular localization of PfOTU, and its association with the apicoplast...
April 18, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28422440/blood-parameters-of-preterm-neonates-postnatal-evolution-according-to-gestational-age
#4
P Roudil, C Vasselon, B Trombert-Paviot, C Berger, H Patural
INTRODUCTION: The blood count provides qualitative and quantitative essential information on bloodlines. Reference hematologic parameters have been established in children and neonates, but few data are available regarding the premature population during the first month of life. The main objective of this study was to establish normative values for blood parameters for premature infants born between 26 and <37 weeks of gestation, during the first month of life, taking into account gestational and postnatal age and treatments that can impact the threshold values...
April 19, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28422042/synchronous-penoscrotal-implantation-of-penile-prosthesis-and-artificial-urinary-sphincter-after-radical-prostatectomy
#5
Deniz Bolat, Zafer Kozacioglu, Salih Polat, Omer Koras, Murat Arslan, Suleyman Minareci
OBJECTIVES: To evaluate the results of synchronous dual implantation of penile (PP) and artificial urinary sphincter prosthesis (AUSP) in patients with severe erectile dysfunction (ED) and urinary incontinence (UI) after radical prostatectomy (RP). METHODS: Between January 2006 and March 2015, patients who underwent synchronous dual implantation of PP for severe post-RP ED and AUSP for moderate to severe post-RP UI in our clinic were screened retrospectively. The erectile function and the continence status were evaluated by the questionnaires of IIEF-5 and ICIQ-SF...
April 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28419385/development-and-feasibility-of-a-group-based-therapeutic-yoga-program-for-women-with-chronic-pelvic-pain
#6
Alison J Huang, Tami S Rowen, Priscilla Abercrombie, Leslee L Subak, Michael Schembri, Traci Plaut, Maria T Chao
Objective.:  To develop a group-based therapeutic yoga program for women with chronic pelvic pain (CPP) and explore the effects of this program on pain severity, sexual function, and well-being. Methods.:  A yoga therapy program for CPP was developed by a multidisciplinary panel of clinicians, researchers, and yoga consultants. Women reporting moderate to severe pelvic pain for at least six months were recruited into a single-arm trial. Participants attended twice weekly group classes focusing on Iyengar-based yoga techniques and were instructed to practice yoga at home an hour a week for six weeks...
April 15, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28415538/fabrication-of-polypropylene-silver-nanocomposites-for-biocidal-applications
#7
Washington Luiz Oliani, Duclerc Fernandes Parra, Luiz Gustavo Hiroki Komatsu, Nilton Lincopan, Vijaya Kumar Rangari, Ademar Benevolo Lugao
This paper presents a study on biocidal effect of polymer nanocomposite films of gamma irradiated polypropylene (PP) and silver nanoparticles. The modified polypropylene was obtained from isotactic polypropylene (iPP) in pellets form by irradiation with gamma rays in the presence of acetylene. A new morphology with long chain branching of PP and distinct rheology is obtained by this process. The blend of 50/50wt% neat PP and PP modified by gamma radiation were further mixed using a twin screw extruder. The AgNPs were infused into this polymer blend at different concentrations of: 0...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28404687/selective-calcium-dependent-inhibition-of-atp-gated-p2x3-receptors-by-bisphosphonates-induced-endogenous-atp-analogue-apppi
#8
Yevheniia Ishchenko, Anastasia Shakirzyanova, Raisa Giniatullina, Andrei Skorinkin, Geneviev Bart, Petri Turhanen, Jorma Maatta, Jukka Monkkonen, Rashid Giniatullin
Pain is the most unbearable symptom accompanying primary bone cancers and bone metastases. Bone resorptive disorders are often associated with hypercalcemia contributing to the pathological process. Nitrogen-containing bisphosphonates (NBP) are efficiently used to treat bone-cancers and metastases. NBP, apart from their toxic effect on cancer cells, also provide analgesia via poorly understood mechanisms. We have previously shown, that NBP, by inhibiting the mevalonate pathway, induced the formation of the novel ATP-analogues such as ApppI which can potentially be involved in NBP analgesia...
April 12, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28403592/comparison-of-transurethral-incision-of-the-prostate-and-silodosin-in-patients-having-benign-prostatic-obstruction-in-terms-of-retrograde-ejaculation
#9
Basri Cakiroglu, Aydin Ismet Hazar, Orhun Sinanoglu, Ersan Arda, Sinan Ekici
BACKGROUND: To compare the functional outcomes and retrograde ejaculation (RE) after transurethral incision of the prostate (TUIP) or silodosin in bladder outlet obstruction (BOO) secondary to a small prostate. METHODS: Prospectively collected data from December 2011 through December 2014 of 192 LUTS patients having fertility concerns with prostate volume smaller than 40 ml receiving either TUIP or silodosin treatment were prospectively reviewed. The treatment outcomes were evaluated and compared...
March 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28389395/high-throughput-enzyme-screening-platform-for-the-ipp-bypass-mevalonate-pathway-for-isopentenol-production
#10
Aram Kang, Corey W Meadows, Nicolas Canu, Jay D Keasling, Taek Soon Lee
Isopentenol (or isoprenol, 3-methyl-3-buten-1-ol) is a drop-in biofuel and a precursor for commodity chemicals such as isoprene. Biological production of isopentenol via the mevalonate pathway has been optimized extensively in Escherichia coli, yielding 70% of its theoretical maximum. However, high ATP requirements and isopentenyl diphosphate (IPP) toxicity pose immediate challenges for engineering bacterial strains to overproduce commodities utilizing IPP as an intermediate. To overcome these limitations, we developed an "IPP-bypass" isopentenol pathway using the promiscuous activity of a mevalonate diphosphate decarboxylase (PMD) and demonstrated improved performance under aeration-limited conditions...
April 5, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28381888/global-health-education-in-doctor-of-pharmacy-programs-in-the-united-states
#11
Gina M Prescott, Betty N Vu, Naser Z Alsharif, William Allan Prescott
Objective. To determine the extent and manner in which global health education is taught at US PharmD programs. Methods. A pre-tested 40-question electronic survey instrument was developed and sent to each of the 127 accredited or candidate-status US doctor of pharmacy (PharmD) programs. Results. Twenty-eight public and 27 private PharmD programs responded to the survey (43.3%). Twenty-five (45.5%) programs had integrated global health topics into their required didactic curriculum, and 30 of 52 programs (57...
March 25, 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28371337/novel-strategy-for-the-facile-enrichment-of-isopentenyl-pyrophosphate-in-rat-plasma-via-ti-4-immobilized-polydopamine-fe3-o4-core-shell-microspheres
#12
Chen Xu, Yingjia Yu, Li Ling, Xueni Sun, Yan Li, Gengli Duan
In this paper, a facile extraction strategy is reported for the analysis of isopentenyl pyrophosphate, a key isoprenoid, based on magnetic core-shell microspheres with Ti(4+) ion exterior walls coupled with liquid chromatography and tandem mass spectrometry. Because of their excellent hydrophilicity and biological compatibility, the polydopamine@Fe3 O4 -Ti(4+) microspheres display ideal isopentenyl pyrophosphate extraction efficiency. The technique includes three steps: sample loading, nonphosphate washing, and phosphate elution...
March 28, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28356213/organizational-readiness-for-change-preceptor-perceptions-regarding-early-immersion-of-student-pharmacists-in-health-system-practice
#13
Kimberly A Sanders, Michael D Wolcott, Jacqueline E McLaughlin, Amanda D'Ostroph, Christopher M Shea, Nicole R Pinelli
PURPOSE: To examine preceptors' perceptions regarding readiness for change pre- and post-implementation of a pilot early immersion program engaging student pharmacists in direct patient care. METHODS: Student pharmacists enrolled in the second professional year of a Doctor of Pharmacy degree program completed a four-week health-system introductory pharmacy practice experience (IPPE) which was modified to include direct patient care roles in operational (drug preparation and dispensing) and clinical (comprehensive medication management) pharmacy environments...
March 10, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28343599/presence-characteristics-and-volumes-of-coronary-plaque-determined-by-computed-tomography-angiography-in-young-type-2-diabetes-mellitus
#14
Negin Nezarat, Matthew J Budoff, Yanting Luo, Sirous Darabian, Rine Nakanishi, Dong Li, Nasim Sheidaee, Michael Kim, Anas Alani, Suguru Matsumoto, Sina Rahmani, Mitsuru Kanisawa, Indre Ceponiene, Kazuhiro Osawa, Hong Qi, Sajad Hamal, Pieter Kitslaar, Alexander Broersen, Ferdinand Flores, Eli Ipp, Bahram Khazai
Prevention and management of coronary artery disease (CAD) is of great concern in patients with diabetes mellitus. Although the impact of coronary atherosclerosis is described well for subjects older than 40 years, the prevalence and types of coronary atherosclerosis in young patients are not well known. The aim of this study was to evaluate the prevalence, extent, severity, and volumes of coronary plaque in type 2 diabetes mellitus (T2DM) population younger than of 40 years. This prospective study enrolled 181 subjects (25-40 year old) undergoing coronary computed tomography angiography, with 86 T2DM and 95 nondiabetic age/gender-matched subjects...
March 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28342224/interleukin-18-activates-vg9vd2-t-cells-from-hiv-individuals-recovering-the-response-to-phosphoantigen
#15
Alanna S Murday, Suchita Chaudhry, C David Pauza
OBJECTIVE: Identify an immunoregulatory factor that restores the phosphoantigen response of Vg9Vd2+ T cells from HIV+ individuals on antiretroviral therapy. DESIGN: Characterize the effects of IL-18 on proliferation and effector function in Vg9Vd2 T cells from HIV-negative individuals. Test whether exogenous IL-18 reconstitutes the Vg9Vd2 T cell response to phosphoantigen from HIV-positive donors. METHODS: The Vg9Vd2 T cells from HIV-negative individuals respond strongly to phosphoantigen or aminobisphosphonate stimulation of PBMC, while cells with similar T cell receptor profiles from HIV+ individuals only respond to aminobisphosphonate...
March 25, 2017: Immunology
https://www.readbyqxmd.com/read/28334935/genome-wide-association-study-of-iron-traits-and-relation-to-diabetes-in-the-hispanic-community-health-study-study-of-latinos-hchs-sol-potential-genomic-intersection-of-iron-and-glucose-regulation
#16
Laura M Raffield, Tin Louie, Tamar Sofer, Deepti Jain, Eli Ipp, Kent D Taylor, George J Papanicolaou, Larissa Avilés-Santa, Leslie A Lange, Cathy C Laurie, Matthew P Conomos, Timothy A Thornton, Yii-Der Ida Chen, Qibin Qi, Scott Cotler, Bharat Thyagarajan, Neil Schneiderman, Jerome I Rotter, Alex P Reiner, Henry J Lin
Genetic variants contribute to normal variation of iron-related traits and may also cause clinical syndromes of iron deficiency or excess. Iron overload and deficiency can adversely affect human health. For example, elevated iron storage is associated with increased diabetes risk, although mechanisms are still being investigated. We conducted the first genome-wide association study (GWAS) of serum iron, total iron binding capacity (TIBC), transferrin saturation, and ferritin in a Hispanic/Latino cohort, the Hispanic Community Health Study/Study of Latinos (HCHS/SOL; >12,000 participants) and also assessed the generalization of previously known loci to this population...
March 7, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28332122/cognitive-impairments-and-predominant-polarity-in-bipolar-disorder-a-cross-sectional-study
#17
Gabriel Okawa Belizario, Alexandre Duarte Gigante, Cristiana Castanho de Almeida Rocca, Beny Lafer
BACKGROUND: Bipolar disorder (BD) patients exhibit cognitive impairments during euthymic states. Studies suggest that manic episodes may be correlated to cognitive impairments. The present study investigated the relationship between predominant polarity and the cognitive deficits frequently detected in bipolar patients. We hypothesize that mania predominant polarity (MPP) patients should exhibit greater cognitive impairments in comparison to depressive (DPP) and indefinite predominant polarity (IPP) patients and healthy control (HC) individuals...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28316267/efficacy-of-a-computer-based-cognitive-training-program-in-older-people-with-subjective-memory-complaints-a-randomized-study
#18
Angela J Pereira-Morales, Andrés F Cruz Salinas, Jairo Aponte Melo, Francisco Pereira Manrique
OBJECTIVE: the aim of this study was to investigate the effect of computer-assisted cognitive training in healthy older adults with subjective memory complaints. METHODS: 40 older adults, mean age (standard Deviation) = 66.4 (5.6) with subjective memory complaints, were included in this study. Participants were randomly assigned to an Integrated Psychostimulation Program (IPP) (N = 17), a Computerized Cognitive Training (CCT) (N = 12) or a control group (N = 11)...
March 20, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28315445/evaluation-of-pept1-transport-of-food-derived-antihypertensive-peptides-ile-pro-pro-and-leu-lys-pro-using-in-vitro-ex-vivo-and-in-vivo-transport-models
#19
John P Gleeson, David J Brayden, Sinéad M Ryan
Ile-Pro-Pro (IPP) and Leu-Lys-Pro (LKP) are food-derived antihypertensive peptides which inhibit angiotensin-converting enzyme (ACE) and may have potential to attenuate hypertension. There is debate over their mechanism of uptake across small intestinal epithelia, but paracellular and PepT1 carrier-mediated uptake are thought to be important routes. The aim of this study was to determine their routes of intestinal permeability using in vitro, ex vivo and in vivo intestinal models. The presence of an apical side pH of 6...
March 14, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28289309/promoting-professional-socialization-within-the-experiential-curriculum-implementation-of-a-high-stakes-professionalism-rubric
#20
Kim Tanzer, Matthew Dintzner
Objectives. To describe the implementation of a high-stakes rubric to assess student professionalism in introductory and advanced pharmacy practice experiences (IPPEs and APPEs) to promote the professional socialization of students in the doctor of pharmacy (PharmD) program at Western New England University (WNE). Findings. A professionalism rubric was adapted from the literature to assess the professional behavior of students enrolled in experiential courses based on evaluation of the following criteria: appropriate communication skills with patients and providers, appearance and dress code, timeliness, and initiative...
February 25, 2017: American Journal of Pharmaceutical Education
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