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https://www.readbyqxmd.com/read/29144629/single-perineal-incision-placement-of-artificial-urinary-sphincter-with-cadaveric-correlation-of-sub-dartos-pump-placement
#1
Cooper R Benson, Hajar I Ayoub, O Lenaine Westney
PURPOSE: We present a novel AUS implantation technique using a single perineal incision for single device placement or in combination with an inflatable penile prosthesis (IPP). Urinary and sexual dysfunction following the management of prostate cancer has a significant impact on the quality of life of our patients. While there are marginal changes in the prosthetic devices, we strive to reduce post-operative morbidity while maximizing efficacy. MATERIALS AND METHODS: We retrospectively reviewed the outcomes of 6 patients who underwent single perineal incision placement of a virgin AUS in 2014, 3 with simultaneous IPP placement...
November 19, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29143298/a-single-nucleotide-mutation-of-ispf-gene-involved-in-the-mep-pathway-for-isoprenoid-biosynthesis-causes-yellow-green-leaf-phenotype-in-rice
#2
Rui Huang, Yang Wang, Pingrong Wang, Chunmei Li, Fuliang Xiao, Nenggang Chen, Na Li, Caixia Li, Changhui Sun, Lihua Li, Rongjun Chen, Zhengjun Xu, Jianqing Zhu, Xiaojian Deng
We identified IspF gene through yellow-green leaf mutant 505ys in rice. OsIspF was expressed in all tissues detected, and its encoded protein was targeted to the chloroplast. On expression levels of genes in this mutant, OsIspF itself and the genes encoding other enzymes of the MEP pathway and chlorophyll synthase were all up-regulated, however, among eight genes associated with photosynthesis, only psaA, psaN and psbA genes for three reaction center subunits of photosystem obviously changed. Isoprenoids are the most abundant natural compounds in all organisms, which originate from the basic five-carbon units isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP)...
November 15, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/29142397/chemical-composition-antimicrobial-and-antitumor-potentiality-of-essential-oil-of-ferula-tingitana-l-apiaceae-grow-in-libya
#3
Waleed Elghwaji, Abeer Mohamed El-Sayed, Kadriya S El-Deeb, Aly M ElSayed
Background: Ferula tingitana L. (Apiaceae) has been considered to have abortive and menstruation-inducing properties. It used to treat sore throat, fever, indigestion, and pains. Objectives: The objective of this study is to establish the chemical composition of the essential oil of flower, leaves of F. tingitana, and to throw light on antimicrobial, cytotoxic activities of Libyan plant. Materials and Methods: The chemical composition of the essential oil of flower (0...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29141210/pfclpc-is-an-essential-clp-chaperone-required-for-plastid-integrity-and-clp-protease-stability-in-plasmodium-falciparum
#4
Anat Florentin, David W Cobb, Jillian D Fishburn, Michael J Cipriano, Paul S Kim, Manuel A Fierro, Boris Striepen, Vasant Muralidharan
The deadly malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid, known as the apicoplast, that functions to produce essential metabolites, and drugs that target the apicoplast are clinically effective. Several prokaryotic caseinolytic protease (Clp) genes have been identified in the Plasmodium genome. Using phylogenetic analysis, we focused on the Clp members that may form a regulated proteolytic complex in the apicoplast. We genetically targeted members of this complex and generated conditional mutants of the apicoplast-localized PfClpC chaperone and PfClpP protease...
November 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/29135135/-ultrasound-indicators-of-the-prostate-urinary-bladder-and-uroflowmetry-parameters-in-the-diagnosis-of-infravesical-obstruction-in-men-with-benign-prostatic-hyperplasia
#5
G G Krivoborodov, N S Efremov, A D Bolotov
RELEVANCE: Benign prostatic hyperplasia (BPH) is one of the most common urologic diseases of males. In patients who failed drug therapy of lower urinary tract symptoms (LUTS) caused by BPH, the most important indication for surgery is the presence of infravesical obstruction (IVO). IVO is detected by pressure-flow studies and is characterized by high detrusor pressure with decreased urinary flow rate. The invasiveness and high cost of this investigation has stimulated a search for non-invasive techniques that could reliably characterize the presence of IVO secondary to BPH...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29118396/engineering-saccharomyces-cerevisiae-for-geranylgeraniol-overproduction-by-combinatorial-design
#6
Tian-Qing Song, Ming-Zhu Ding, Fang Zhai, Duo Liu, Hong Liu, Wen-Hai Xiao, Ying-Jin Yuan
Combinatorial design is an effective strategy to acquire the optimal solution in complex systems. In this study, the combined effects of pathway combination, promoters' strength fine-tuning, copy numbers and integration locus variations caused by δ-integration were explored in Saccharomyces cerevisiae using geranylgeraniol (GGOH) production as an example. Two GGOH biosynthetic pathway branches were constructed. In branch 1, GGOH was converted from isopentenyl pyrophosphate (IPP) and farnesyl diphosphate (FPP)...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29109165/validation-of-putative-apicoplast-targeting-drugs-using-a-chemical-supplementation-assay-in-cultured-human-malaria-parasites
#7
Taher Uddin, Geoffrey Ian McFadden, Christopher Dean Goodman
Malaria parasites contain a relict plastid, the apicoplast, which is considered an excellent drug target due to its bacterial-like ancestry. Numerous parasiticidals have been proposed to target the apicoplast, but few have had their actual targets substantiated. Isopentenyl pyrophosphate (IPP) production is the sole required function of the apicoplast in the blood stage of the parasite life cycle, and IPP supplementation rescues parasites from apicoplast perturbing drugs. Hence, any drug that kills parasites when IPP is supplied in culture must have a non-apicoplast target...
November 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29101014/integrin-linked-kinase-a-new-actor-in-the-ageing-process
#8
Gemma Olmos, Susana López-Ongil, Maria Piedad Ruiz Torres
Integrin-linked kinase (ILK) is a protein located in focal adhesion complexes that is linked to the cytoplasmic domain of integrin receptors. Together with PINCH and parvin, ILK forms the IPP complex, which is associated with conserved intracellular signalling pathways and integrin regulation of the actin cytoskeleton. ILK plays an essential role in a wide variety of cellular functions, including cell migration, differentiation, survival, and division. The present review summarizes recent evidence, suggesting a new role for ILK in organismal ageing and cellular senescence, indicating that ILK is a key regulator of longevity and premature cellular senescence induced by extracellular stressors...
October 31, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29076562/a-systematic-review-of-empirical-studies-on-methodology-and-burden-of-informal-patient-payments-in-health-systems
#9
REVIEW
Abdolvahed Khodamoradi, Mohammad Payam Ghaffari, Reza Daryabeygi-Khotbehsara, Haniye Sadat Sajadi, Reza Majdzadeh
INTRODUCTION: Informal patients' payments (IPPs) is a sensitive subject. The aim of current study was to assess the trends in informal payment studies and explore methods of IPPs measurement, prevalence, and features (payment type, volume, and receiver) in various contexts. METHODS: A search strategy was developed to identify peer-reviewed articles addressing informal payments on PubMed, Science Direct, Web of Science, Scopus, and CINAHL. A total of 1252 studies were identified initially...
October 27, 2017: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/29075200/neuromuscular-adaptations-to-multimodal-injury-prevention-programs-in-youth-sports-a-systematic-review-with-meta-analysis-of-randomized-controlled-trials
#10
Oliver Faude, Roland Rössler, Erich J Petushek, Ralf Roth, Lukas Zahner, Lars Donath
Objective: Neuromuscular injury prevention programs (IPP) can reduce injury rate by about 40% in youth sport. Multimodal IPP include, for instance, balance, strength, power, and agility exercises. Our systematic review and meta-analysis aimed to evaluate the effects of multimodal IPP on neuromuscular performance in youth sports. Methods: We conducted a systematic literature search including selected search terms related to youth sports, injury prevention, and neuromuscular performance. Inclusion criteria were: (i) the study was a (cluster-)randomized controlled trial (RCT), and (ii) investigated healthy participants, up to 20 years of age and involved in organized sport, (iii) an intervention arm performing a multimodal IPP was compared to a control arm following a common training regime, and (iv) neuromuscular performance parameters (e...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29072835/biological-studies-and-target-engagement-of-the-2-c-methyl-d-erythritol-4-phosphate-cytidylyltransferase-ispd-targeting-antimalarial-agent-1r-3s-mmv008138-and-analogs
#11
Maryam Ghavami, Emilio F Merino, Zhong-Ke Yao, Rubayet Elahi, Morgan E Simpson, Maria L Fernández-Murga, Joshua H Butler, Michael A Casasanta, Priscilla M Krai, Maxim M Totrov, Daniel J Slade, Paul R Carlier, Maria Belen Cassera
Malaria continues to be one of the deadliest diseases worldwide, and the emergence of drug resistance parasites is a constant threat. Plasmodium parasites utilize the methylerythritol phosphate (MEP) pathway to synthesize isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP), which are essential for parasite growth. Previously, we and others identified that the Malaria Box compound MMV008138 targets the apicoplast and that parasite growth inhibition by this compound can be reversed by supplementation of IPP...
November 7, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29059744/re-a-retrospective-analysis-of-risk-factors-for-ipp-reservoir-entry-into-the-peritoneum-after-abdominal-wall-placement
#12
Allen D Seftel
No abstract text is available yet for this article.
November 2017: Journal of Urology
https://www.readbyqxmd.com/read/29054697/a-novel-method-for-oxygen-glucose-deprivation-model-in-organotypic-spinal-cord-slices
#13
Jing-Jie Liu, Xiao-Yan Ding, Li Xiang, Feng Zhao, Sheng-Li Huang
This study aimed to establish a model to closely mimic spinal cord hypoxic-ischemic injury with high production and high reproducibility. Fourteen-day cultured organotypic spinal cord slices were divided into 4 groups: control (Ctrl), oxygen glucose deprived for 30min (OGD 30min), OGD 60min, and OGD 120min. The Ctrl slices were incubated with 1ml propidium iodide (PI) solution (5μg/ml) for 30min. The OGD groups were incubated with 1ml glucose-free DMEM/F12 medium and 5μl PI solution (1mg/ml) for 30min, 60min and 120min, respectively...
October 17, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29037930/adolescent-parent-dyad-descriptions-of-the-decision-to-start-the-hpv-vaccine-series
#14
Jane Chang, Lisa S Ipp, Ariel M de Roche, Marina Catallozzi, Carmen Radecki Breitkopf, Susan L Rosenthal
STUDY OBJECTIVE: To examine how adolescent-parent dyads describe decision-making regarding initiation of the human papillomavirus (HPV) vaccine series, specifically who they viewed as making the final decision. DESIGN: Semistructured interviews with adolescent-parent dyads were audio-recorded and transcribed. Responses to the question: "How did you make a decision about whether or not to receive the HPV vaccine series?" were content-coded for each individual member of the dyad...
October 13, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29028036/synthesis-and-characterization-of-depolarizing-samples-based-on-the-indices-of-polarimetric-purity
#15
Albert Van Eeckhout, Angel Lizana, Enric Garcia-Caurel, José J Gil, Razvigor Ossikovski, Juan Campos
In this work, we discuss the interest of using the indices of polarimetric purity (IPPs) as a criterion for the characterization and classification of depolarizing samples. We prove how differences in the depolarizing capability of samples, not seen by the commonly used depolarization index PΔ, are identified by the IPPs. The above-stated result is analyzed from a theoretical point of view and experimentally verified through a set of polarimetric measurements. We show how the approach presented here can be useful in easily synthetizing depolarizing samples with controlled depolarizing features, just by properly combining low-cost fully polarizing elements (such as linear retarders or polarizers)...
October 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29025876/mevalonate-5-diphosphate-mediates-atp-binding-to-the-mevalonate-diphosphate-decarboxylase-from-the-bacterial-pathogen-enterococcus-faecalis
#16
Chun-Liang Chen, James C Mermoud, Lake N Paul, Calvin Nicklaus Steussy, Cynthia V Stauffacher
The mevalonate pathway produces isopentenyl diphosphate (IPP), a building block for polyisoprenoid synthesis, and is a crucial pathway for growth of the human bacterial pathogen Enterococcus faecalis. The final enzyme in this pathway, mevalonate diphosphate decarboxylase (MDD), acts on mevalonate diphosphate (MVAPP) to produce IPP while consuming ATP. This essential enzyme has been suggested as a therapeutic target for the treatment of drug-resistant bacterial infections. Here we report functional and structural studies on the mevalonate diphosphate decarboxylase from E...
October 12, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29021105/invasive-pneumococcal-pneumonia-caused-by-13-valent-pneumococcal-conjugate-vaccine-types-in-children-with-different-schedules
#17
Hong-Yi Lee, Yu-Chia Hsieh, Ching-Chuan Liu, Yi-Chuan Huang, Kuang-Yi Chang, Hsin Chi, Luan-Yin Chang, Yhu-Chering Huang, Li-Min Huang
BACKGROUND: In Taiwan, the age group with the greatest incidence of invasive pneumococcal disease is 2-5 years of age, which is different from other countries. This study was conducted to identify risk factors and different 13-valent pneumococcal conjugate vaccine (PCV13) schedules associated with vaccine-type invasive pneumococcal pneumonia (IPP) despite prior vaccination. METHODS: A case-control study was conducted prospectively between August 2012 and December 2015 at five participating medical centers...
September 27, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28990832/complex-interplays-between-phytosterols-and-plastid-development
#18
Paola Andrade, Daniel Caudepon, Teresa Altabella, Montserrat Arró, Albert Ferrer, David Manzano
Isoprenoids comprise the largest class of natural compounds and are found in all kinds of organisms. In plants, they participate in both primary and specialized metabolism, playing essential roles in nearly all aspects of growth and development. The enormous diversity of this family of compounds is extensively exploited for biotechnological and biomedical applications as biomaterials, biofuels or drugs. Despite their variety of structures, all isoprenoids derive from the common C5 precursor Isopentenil diphosphate (IPP)...
October 9, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28988803/effects-of-the-bioactive-peptides-ile-pro-pro-and-val-pro-pro-upon-autonomic-neurotransmission-and-blood-pressure-in-spontaneously-hypertensive-rats
#19
Hidetoshi Miyazaki, Teppei Nakamura, Kohji Ohki, Katsuya Nagai
The bioactive peptides Ile-Pro-Pro (IPP) and Val-Pro-Pro (VPP) are believed to improve blood pressure and arterial function. To gain a better understanding of the mechanisms underlying the action of these peptides, we investigated their effects upon autonomic neurotransmission and blood pressure in spontaneously hypertensive rats (SHR). Both IPP and VPP caused a significant reduction in cutaneous arterial sympathetic nerve activity (CASNA) and reduced mean arterial pressure (MAP); however, both of these effects were eliminated following sub-diaphragmatic vagotomy...
September 29, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28981211/polarimetric-imaging-of-biological-tissues-based-on-the-indices-of-polarimetric-purity
#20
Albert Van Eeckout, Angel Lizana, Enric Garcia-Caurel, José J Gil, Adrià Sansa, Carla Rodríguez, Irene Estévez, Emilio González, Juan Carlos Escalera, Ignacio Moreno, Juan Campos
We highlight the interest of using the Indices of Polarimetric Purity (IPPs) to the inspection of biological tissues. The IPPs were recently proposed in the literature and they result in a further synthetization of the depolarizing properties of samples. Compared with standard polarimetric images of biological samples, IPPs based images lead to larger image contrast of some biological structures and to a further physical interpretation of the depolarizing mechanisms inherent to the samples. In addition, unlike other methods, their calculation do not require advanced algebraic operations (as is the case of polar decompositions), and they result in three indicators of easy implementation...
October 5, 2017: Journal of Biophotonics
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