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https://www.readbyqxmd.com/read/28102554/what-are-the-predicting-factors-for-the-therapeutic-effects-of-dutasteride-in-male-patients-with-lower-urinary-tract-symptoms-investigation-using-a-urodynamic-study
#1
Yoshihisa Matsukawa, Masashi Kato, Yasuhito Funahashi, Tsuyoshi Majima, Tokunori Yamamoto, Momokazu Gotoh
AIMS: We investigated predicting factors for the therapeutic effects of dutasteride in patients with lower urinary tract symptoms (LUTS) due to benign prostatic enlargement (BPE) based on a urodynamic study (UDS). METHODS: This was a single-center, prospective study involving 120 male outpatients with LUTS. They received 0.5 mg of dutasteride per day for 12 months. IPSS, OABSS, IPSS-QOL, and UDS were used for assessing subjective and objective symptoms prior to and 12 months after administration...
January 19, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28101889/predictors-of-successful-trial-without-catheter-following-acute-urinary-retention-in-benign-prostatic-enlargement-a-single-centre-multivariate-analysis
#2
Ankur Bansal, Aditi Arora
OBJECTIVE: To evaluate the parameters which predict the success or failure of trial without catheter (TWOC) for acute urine retention (AUR). MATERIALS AND METHODS: Medical records of 2 188 patients presenting with first episode of AUR were analyzed. All patients underwent catheterization and were started on α-blocker followed by TWOC. Age, baseline American urological association (AUA) score, prostate volume (PV), residual volume of urine (RV) and intravesical prostatic protrusion (IPP), prostate specific antigen (PSA) were recorded...
January 19, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28093269/invasive-disease-versus-urinary-antigen-confirmed-pneumococcal-community-acquired-pneumonia
#3
Adrian Ceccato, Antoni Torres, Catia Cilloniz, Rosanel Amaro, Albert Gabarrus, Eva Polverino, Elena Prina, Carolina Garcia-Vidal, Eva Muñoz-Conejero, Cristina Mendez, Isabel Cifuentes, Jorge Puig de la Bella Casa, Rosario Menendez, Michael S Niederman
OBJECTIVES: The burden of pneumococcal disease is measured only through patients with invasive pneumococcal disease. The urinary antigen test (UAT) for pneumococcus has exhibited a high sensitivity and specificity. We aimed to compare the pneumococcal pneumonias diagnosed as invasive disease with pneumococcal pneumonias defined by UAT. METHODS: Prospective observational study on consecutive non-immunosuppressed patients with community-acquired pneumonia from January 2000 to December 2014...
January 13, 2017: Chest
https://www.readbyqxmd.com/read/28089244/synchronous-ipsilateral-high-submuscular-placement-of-prosthetic-balloons-and-reservoirs
#4
Nicholas L Kavoussi, Matthias D Hofer, Boyd R Viers, Billy H Cordon, Ryan P Mooney, Travis J Pagliara, Jeremy M Scott, Allen F Morey
INTRODUCTION: Synchronous ipsilateral high submuscular placement of artificial urinary sphincter (AUS) pressure-regulating balloons (PRBs) and inflatable penile prosthesis (IPP) reservoirs in a single submuscular tunnel is a novel strategy that could be advantageous for patients who have had major pelvic surgery. AIM: To report our initial experience with synchronous ipsilateral vs bilateral placement of AUS PRBs and IPP reservoirs in men undergoing implant surgery...
January 11, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28074495/comparison-of-medicaid-payments-relative-to-medicare-using-inpatient-acute-care-claims-from-the-medicaid-program-fiscal-year-2010-fiscal-year-2011
#5
Devin A Stone, Bridget A Dickensheets, John A Poisal
OBJECTIVE: To compare Medicaid fee-for-service (FFS) inpatient hospital payments to expected Medicare payments. DATA SOURCES: Medicaid and Medicare claims data, Medicare's MS-DRG grouper and inpatient prospective payment system pricer (IPPS pricer). STUDY DESIGN: Medicaid FFS inpatient hospital claims were run through Medicare's MS-DRG grouper and IPPS pricer to compare Medicaid's actual payment against what Medicare would have paid for the same claim...
January 10, 2017: Health Services Research
https://www.readbyqxmd.com/read/28064297/a-clinical-audit-of-interventional-pain-procedures-performed-as-part-of-the-newly-initiated-pain-service-in-a-local-neurosurgical-centre
#6
H C Khoo, B H Soon, A S Jaafar, A Abu Bakar, F Fadzil, K Palaniandy, S Paramasvaran, Y C Choy, C J Toh
Interventional Pain Procedures (IPPs) is a relatively new treatment modality for chronic pain in Malaysia. The Interventional Pain Service (IPS) newly set up in our institution is led by a pain neurosurgeon and provides a whole package of multimodal pain management including different range of IPPs. This clinical audit is to examine the quality of IPPs performed within the IPS in our institution since its initiation. A total of 87 IPPs were performed on 56 chronic pain patients over 3-year duration. As high as 81...
October 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28029370/pneumoperitoneum-and-hemodynamic-stability-during-pediatric-laparoscopic-appendectomy
#7
Go Miyano, Hiroki Nakamura, Shogo Seo, Ryo Sueyoshi, Manabu Okawada, Takashi Doi, Hiroyuki Koga, Geoffrey J Lane, Atsuyuki Yamataka
BACKGROUND: Conventional pneumoperitoneum (CP) and automatically maintained pneumoperitoneum using AirSeal Intelligent Flow System (AiFS) were compared during pediatric laparoscopic appendectomy (LA) using intraperitoneal pressure (IPP) and hemodynamic parameters. METHODS: A prospective review of 39 children aged 3-14years who had standard 3-trocar LA was performed. Pneumoperitoneum was either AiFS (n=18) or CP (n=21) according to the surgeon's preference. IPP during insertion of trocars in all subjects was initially 8-10mmHg, which was reduced to 5mmHg then maintained until LA was completed...
September 15, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27999508/validation-of-the-patient-global-impression-of-improvement-for-penile-prosthesis
#8
Sean Douglas, Austin Lutz, Kevin T McVary, Puneet Masson, Jack Christian Winters, Eric Laborde
BACKGROUND: No consensus on the preferred means of evaluating patients after surgical placement of an inflatable penile prosthesis (IPP) currently exists. Many self-assessment questionnaires are available, but none specifically targets patients with IPPs. The purpose of this study was to assess the construct validity of the Patient Global Impression of Improvement (PGI-I) for evaluating patient satisfaction after placement of an IPP. METHODS: We conducted a multicenter prospective trial and enrolled patients who elected to have a 3-piece IPP surgically implanted...
2016: Ochsner Journal
https://www.readbyqxmd.com/read/27987130/ultrasound-image-features-of-intravesical-prostatic-protrusion-indicated-failure-of-medication-therapy-of-finasteride-and-doxazosin-in-patients-with-benign-prostatic-hyperplasia-luts-bph
#9
Qiang Liu, Yunkai Zhu, Jianping Liu, Jun Qi, Jian Kang
BACKGROUND: Intravesical prostatic protrusion (IPP) is a type of benign prostatic hyperplasia (BPH) adenoma, and it plays a critical role in the pathogenesis of bladder outlet obstruction in patients with lower urinary tract syndromes (LUTS/BPH). AIMS: The goal of this study was to investigate the effect of a combination therapy with finasteride and doxazosin on IPP in BPU/LUTS patients. METHODS: A total of 322 BPH patients with enlarged prostatic volume as well as moderate to severe symptom scores were enrolled and divided into four groups according to the degree of IPP (IPP > 10 mm, 5-10 mm, <5 mm and no IPP) in this study...
December 16, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27956393/relative-effectiveness-of-additive-pain-interventions-during-vaccination-in-infants
#10
Anna Taddio, Rebecca Pillai Riddell, Moshe Ipp, Steven Moss, Stephen Baker, Jonathan Tolkin, Dave Malini, Sharmeen Feerasta, Preeya Govan, Emma Fletcher, Horace Wong, Caitlin McNair, Priyanjali Mithal, Derek Stephens
BACKGROUND: Vaccine injections can cause acute pain and distress in infants, which can contribute to dissatisfaction with the vaccination experience and vaccine hesitancy. We sought to compare the effectiveness of additive pain interventions administered consistently during vaccine injections in the first year of life. METHODS: We conducted a multicentre, longitudinal, double-blind, add-on, randomized controlled trial. Healthy infants were randomly assigned to 1 of 4 levels of pain management for all vaccine injections at 2, 4, 6 and 12 months: (i) placebo control; (ii) parent-directed video education about infant soothing; (iii) the video plus sucrose administered orally or (iv) the video plus sucrose plus liposomal lidocaine applied topically...
December 12, 2016: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/27938025/advancing-hospice-and-palliative-care-social-work-leadership-in-interprofessional-education-and-practice
#11
Susan Blacker, Barbara A Head, Barbara L Jones, Stacy S Remke, Katherine Supiano
The importance of interprofessional collaboration in achieving high quality outcomes, improving patient quality of life, and decreasing costs has been growing significantly in health care. Palliative care has been viewed as an exemplary model of interprofessional care delivery, yet best practices in both interprofessional education (IPE) and interprofessional practice (IPP) in the field are still developing. So, too, is the leadership of hospice and palliative care social workers within IPE and IPP. Generating evidence regarding best practices that can prepare social work professionals for collaborative practice is essential...
October 2016: Journal of Social Work in End-of-life & Palliative Care
https://www.readbyqxmd.com/read/27910026/recurrent-cytogenetic-abnormalities-in-myelodysplastic-syndromes
#12
Meaghan Wall
Cytogenetic analysis has an essential role in diagnosis, classification, and prognosis of myelodysplastic syndromes (MDS). Some cytogenetic abnormalities are sufficiently characteristic of MDS to be considered MDS defining in the appropriate clinical context. MDS with isolated del(5q) is the only molecularly defined MDS subtype. The genes responsible for many aspects of 5q- syndrome, the distinct clinical phenotype associated with this condition, have now been identified. Cytogenetics forms the cornerstone of the most widely adopted prognostic scoring systems in MDS, the international prognostic scoring system (IPSS) and the revised international prognostic scoring system (IPPS-R)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27872031/penile-prosthesis-infections-a-review-of-risk-factors-prevention-and%C3%A2-treatment
#13
REVIEW
Miguel Pineda, Arthur L Burnett
INTRODUCTION: Inflatable penile prosthesis (IPP) surgery has been performed for more than 40 years. IPP infection rates have decreased owing to advances in manufacturing and surgical technique but have remained a devastating complication. AIMS: To describe the pathophysiology of infections, examine evidence associating clinical risk factors with IPP infection, assess the benefit of techniques aimed at preventing and managing infection, and discuss future directions...
October 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27851826/transcriptional-responses-and-gentiopicroside-biosynthesis-in-methyl-jasmonate-treated-gentiana-macrophylla-seedlings
#14
Xiaoyan Cao, Xiaorong Guo, Xinbing Yang, Huaiqin Wang, Wenping Hua, Yihan He, Jiefang Kang, Zhezhi Wang
Gentiana macrophylla, a medicinal plant with significant pharmacological properties, contains the bioactive compound gentiopicroside. Methyl jasmonate (MeJA) is an effective elicitor for enhancing the production of such compounds. However, little is known about MeJA-mediated biosynthesis of gentiopicroside. We investigated this phenomenon as well as gene expression profiles to determine the molecular mechanisms for MeJA-mediated gentiopicroside biosynthesis and regulation in G. macrophylla. Our HPLC results showed that Gentiana macrophylla seedlings exposed to MeJA had significantly higher concentrations of gentiopicroside when compared with control plants...
2016: PloS One
https://www.readbyqxmd.com/read/27814796/access-to-opportunities-for-bilingualism-for-individuals-with-developmental-disabilities-key-informant-interviews
#15
Julia Scherba de Valenzuela, Elizabeth Kay-Raining Bird, Karisa Parkington, Pat Mirenda, Kate Cain, Andrea A N MacLeod, Eliane Segers
The purpose of this article is to describe the results of a thematic analysis of 79 semi-structured interviews collected at six research sites in four countries in relation to the inclusion and exclusion of students with developmental disabilities (DD) in and from special education and bilingual opportunities. The participants were individuals with expertise either in special needs and/or language education to support bilingualism (e.g., second language (L2) instruction), who served as key informants about service delivery and/or policy in these areas...
September 2016: Journal of Communication Disorders
https://www.readbyqxmd.com/read/27790911/release-of-the-antihypertensive-tripeptides-valine-proline-proline-and-isoleucine-proline-proline-from-bovine-milk-caseins-during-in-vitro-gastrointestinal-digestion
#16
Giuseppina Sefora Rutella, Lisa Solieri, Serena Martini, Davide Tagliazucchi
The aim of this study was to identify and quantify the release of antihypertensive tripeptides valine-proline-proline (VPP) and isoleucine-proline-proline (IPP) during in vitro oro-gastro-intestinal (OGI) digestion of bovine skimmed milk. The experimental approach combined the recently developed harmonized static in vitro digestion (IVD) model and targeted mass spectrometry to monitor peptide generation. We first demonstrated that VPP and IPP are released from bovine milk proteins during in vitro OGI digestion at final concentrations of 354...
November 16, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27782611/image-quality-method-as-a-possible-way-of-in-situ-monitoring-of-in-vessel-mirrors-in-a-fusion-reactor
#17
V G Konovalov, V S Voitsenya, M N Makhov, I V Ryzhkov, A N Shapoval, S I Solodovchenko, A F Stan, V N Bondarenko, A J H Donné, A Litnovsky
The plasma-facing (first) mirrors in ITER will be subject to sputtering and/or contamination with rates that will depend on the precise mirror locations. The resulting influence of both these factors can reduce the mirror reflectance (R) and worsen the transmitted image quality (IQ). This implies that monitoring the mirror quality in situ is an actual desire, and the present work is an attempt towards a solution. The method we propose is able to elucidate the reason for degradation of the mirror reflectance: sputtering by charge exchange atoms or deposition of contaminated layers...
September 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27774312/repeatability-and-reproducibility-of-quantitative-corneal-shape-analysis-after-orthokeratology-treatment-using-image-pro-plus-software
#18
Ying Mei, Zhiping Tang, Zhouyue Li, Xiao Yang
Purpose. To evaluate the repeatability and reproducibility of quantitative analysis of the morphological corneal changes after orthokeratology treatment using "Image-Pro Plus 6.0" software (IPP). Methods. Three sets of measurements were obtained: two sets by examiner 1 with 5 days apart and one set by examiner 2 on the same day. Parameters of the eccentric distance, eccentric angle, area, and roundness of the corneal treatment zone were measured using IPP. The intraclass correlation coefficient (ICC) and repetitive coefficient (COR) were used to calculate the repeatability and reproducibility of these three sets of measurements...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27754129/os-25-04-the-changes-of-arterial-stiffness-monitored-with-cardio-ankle-vascular-index-cavi-during-raised-intracranial-pressure-in-the-rabbit
#19
Chikao Miyazaki, Mao Takahashi, Kazuhiro Shimizu, Tatsuo Chiba, Takenori Morisita, Tomoyuki Yamamoto, Nobuo Sugo, Akira Takahara, Kohji Shirai
OBJECTIVE: Cardio ankle vascular index (CAVI) is reflecting stiffness of the arterial tree from the origin of aorta to the ankles. We observed elevated CAVI in patients who suffered from apoplexy attack. To clarify the role and the mechanism by which arterial stiffness elevated just after apoplexy attack, the effect of enhanced intracranial pressure (ICP) by injecting saline into the cisterna magna of the rabbit on blood pressure, CAVI and cervical blood flow, were studied. Furthermore the role of sympathetic nerve was studied...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754016/br-04-2-concentration-response-modeling-of-antihypertensive-drugs-implication-in-clinical-development
#20
Dong-Seok Yim
In the early phase of clinical development of antihypertensive drugs, quantitative modeling to predict their dose-concentration-response relationship is important to plan future clinical development and finding optimal dosage regimen at marketing approval. Two cases of concentration-response models of antihypertensive are presented here.Case 1: Carvedilol is a α1- and nonselective β- adrenergic receptor antagonist currently used for the management of mild-to-moderate essential hypertension and congestive heart failure...
September 2016: Journal of Hypertension
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