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https://www.readbyqxmd.com/read/29329889/exploring-individual-adaptations-to-an-anterior-cruciate-ligament-injury-prevention-programme
#1
Aaron S Fox, Jason Bonacci, Scott G McLean, Natalie Saunders
BACKGROUND: Individual responses to anterior cruciate ligament injury prevention programmes (ACL IPPs) have received little attention. This study examined the effects of an ACL IPP on neuromuscular control and lower limb biomechanics during landing at the group and individual levels. METHODS: Sixteen female athletes were randomly allocated to training (n=8) or control (n=8) groups. Electromyography, and three-dimensional kinematic and kinetic data were collected during landing at two testing sessions...
January 9, 2018: Knee
https://www.readbyqxmd.com/read/29325832/the-pics-technique-a-novel-approach-for-residual-curvature-correction-during-penile-prosthesis-implantation-in-patients-with-severe-peyronie-s-disease-using-the-collagen-fleece-tachosil
#2
Georgios Hatzichristodoulou
BACKGROUND: Correction of residual curvature during inflatable penile prosthesis (IPP) implantation in patients with Peyronie's disease (PD) by plaque incision and grafting is a common approach. AIM: To present a novel technique for residual curvature correction during IPP implantation using collagen fleece (TachoSil, Baxter Healthcare Corp, Deerfield, IL, USA). METHODS: After the IPP (Titan Touch, Coloplast, Minneapolis, MN, USA) is placed, the implant is inflated maximally...
January 8, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29313161/benign-prostatic-hyperplasia-surgical-scoring-bphss-an-novel-scoring-system-for-the-perioperative-outcomes-of-holmium-laser-enucleation-of-the-prostate
#3
Huan Xu, Zhikang Cai, Yanbo Chen, Meng Gu, Qi Chen, Zhong Wang
To develop a standardized scoring system, the BPH surgical scoring (BPHSS) system, to quantify the ability to predict the perioperative outcomes resulting from an enlarged prostate. There are two parts included in this study: the retrospective observational study (875 patients treated with holmium laser enucleation of the prostate, HoLEP) and the prospective observational study (111 patient underwent HoLEP). All the outcome data included the following: the basic patient preoperative characteristics, operation time (OT), pre- and post- surgery hemoglobin decrease, Na+ variation, hospital stay duration, duration of bladder irrigation, catheterization time, and hospitalization time...
January 8, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29311075/phytohormones-isoprenoids-and-role-of-the-apicoplast-in-recovery-from-dihydroartemisinin-induced-dormancy-of-plasmodium-falciparum
#4
Marvin Duvalsaint, Dennis E Kyle
Many organisms undergo dormancy as a stress response to survive under unfavorable conditions that might impede development. This is observed in seed and buds of plants and has been proposed as mechanism of drug evasion and resistance formation in Plasmodium falciparum We explored the effects of the phytohormones, abscisic acid (ABA) and gibberellic acid (GA), on dihydroartemisinin induced dormant erythrocytic stages of P. falciparum parasites. Dormant ring stages exposed to ABA and GA recovered from dormancy up to 48 hr earlier than parasites exposed to DHA alone...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29304113/discovery-of-indolylpiperazinylpyrimidines-with-dual-target-profiles-at-adenosine-a2a-and-dopamine-d2-receptors-for-parkinson-s-disease-treatment
#5
Yi-Ming Shao, Xiaohua Ma, Priyankar Paira, Aaron Tan, Deron Raymond Herr, Kah Leong Lim, Chee Hoe Ng, Gopalakrishnan Venkatesan, Karl-Norbert Klotz, Stephanie Federico, Giampiero Spalluto, Siew Lee Cheong, Yu Zong Chen, Giorgia Pastorin
Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra of the human brain, leading to depletion of dopamine production. Dopamine replacement therapy remains the mainstay for attenuation of PD symptoms. Nonetheless, the potential benefit of current pharmacotherapies is mostly limited by adverse side effects, such as drug-induced dyskinesia, motor fluctuations and psychosis. Non-dopaminergic receptors, such as human A2A adenosine receptors, have emerged as important therapeutic targets in potentiating therapeutic effects and reducing the unwanted side effects...
2018: PloS One
https://www.readbyqxmd.com/read/29302095/the-report-of-the-2016-2017-professional-affairs-standing-committee-formally-embracing-and-engaging-preceptors-in-the-academy-the-time-has-come
#6
Karen Whalen Chair, Daniel S Aistrope, Jason Ausili, Kathleen H Besinque, Elizabeth A Cardello, Philip M Hritcko, George E MacKinnon, Eric Maroyka, Elizabeth Sutton Burke, I Shane Trent, Lynette R Bradley-Baker
The 2016-2017 AACP Professional Affairs Committee (PAC) was charged to examine strategies to include adjunct/affiliate preceptors as AACP members and to determine the value proposition of AACP membership for this group of educators. The PAC defined adjunct/affiliate preceptors as preceptors who are neither full-time employees nor have a primary employment commitment (≥50% of the preceptor's work salary) at a school/college of pharmacy. Specific charges to the PAC included: recommend an approach to increase the number of adjunct/affiliate preceptors as AACP members, examine AACP membership from an adjunct/affiliate preceptor value perspective, and prepare a concise summary of available literature describing value-added contributions of student pharmacists and pharmacy preceptors to pharmacy practice models, interprofessional education (IPE) and interprofessional practice (IPP)...
November 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/29302086/reassessment-of-health-system-capacity-for-experiential-education-requirements
#7
Matthew J Gibson, Lynette R Bradley-Baker, Colleen G Bush, Steven P Nelson
Objective. To provide an update to the 2007 ASHP-AACP survey by examining the current capacity of hospitals/health systems' ability to conduct experiential education for doctor of pharmacy students. Methods. Pharmacists identified as pharmacy directors were sent an invitation to participate in an online survey tool. The survey tool asked IPPE- and APPE-specific questions, the nature of support provided by colleges/schools of pharmacy, the types of experiences available for students, and the factors influencing the quality, value, and challenges of experiential education...
November 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/29295911/atg8-is-essential-specifically-for-an-autophagy-independent-function-in-apicoplast-biogenesis-in-blood-stage-malaria-parasites
#8
Marta Walczak, Suresh M Ganesan, Jacquin C Niles, Ellen Yeh
Plasmodium parasites and related pathogens contain an essential nonphotosynthetic plastid organelle, the apicoplast, derived from secondary endosymbiosis. Intriguingly, a highly conserved eukaryotic protein, autophagy-related protein 8 (ATG8), has an autophagy-independent function in the apicoplast. Little is known about the novel apicoplast function of ATG8 and its importance in blood-stage Plasmodium falciparum Using a P. falciparum strain in which ATG8 expression was conditionally regulated, we showed that P...
January 2, 2018: MBio
https://www.readbyqxmd.com/read/29288392/a-counterforce-to-diversion-of-cerebrospinal-fluid-during-ventriculoperitoneal-shunting-the-intraperitoneal-pressure-an-observational-study
#9
Brit Böse, Veit Rohde, Ingo Fiss, Florian Baptist Freimann
BACKGROUND: Intraperitoneal pressure (IPP) counteracts the diversion of cerebrospinal fluid (CSF) from the cranial to the peritoneal compartment during ventriculoperitoneal shunting. Animal studies suggest that the intrinsic IPP exceeds the intraperitoneal hydrostatic pressure. The intrinsic IPP in mobile patients is relevant for shunt therapy, but data about it is not available. METHODS: The IPP was measured indirectly in 25 mobile subjects (13 female) by applying a standard intravesical pressure measurement technique...
December 29, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29282838/the-inositol-pyrophosphate-pathway-in-health-and-diseases
#10
Anutosh Chakraborty
Inositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds and fungi to mammals. Distinct classes of kinases generate different forms of energetic diphosphate-containing IPPs from inositol phosphates (IPs). Conversely, polyphosphate phosphohydrolase enzymes dephosphorylate IPPs to regenerate the respective IPs. IPPs and/or their metabolizing enzymes regulate various cell biological processes by modulating many proteins via diverse mechanisms. In the last decade, extensive research has been conducted in mammalian systems, particularly in knockout mouse models of relevant enzymes...
December 27, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/29260226/effect-of-cervical-pessary-on-spontaneous-preterm-birth-in-women-with-singleton-pregnancies-and-short-cervical-length-a-randomized-clinical-trial
#11
Gabriele Saccone, Giuseppe Maria Maruotti, Antonia Giudicepietro, Pasquale Martinelli
Importance: Spontaneous preterm birth is a major cause of perinatal morbidity and mortality. It is unclear if a cervical pessary can reduce the risk of spontaneous preterm delivery. Objective: To test whether in asymptomatic women with singleton pregnancies and no prior spontaneous preterm birth but with short cervical length on transvaginal ultrasound, use of a cervical pessary would reduce the rate of spontaneous preterm birth at less than 34 weeks of gestation...
December 19, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29258602/detection-of-prpbse-and-prion-infectivity-in-the-ileal-peyer-s-patch-of-young-calves-as-early-as-2%C3%A2-months-after-oral-challenge-with-classical-bovine-spongiform-encephalopathy
#12
Ivett Ackermann, Anne Balkema-Buschmann, Reiner Ulrich, Kerstin Tauscher, James C Shawulu, Markus Keller, Olanrewaju I Fatola, Paul Brown, Martin H Groschup
In classical bovine spongiform encephalopathy (C-BSE), an orally acquired prion disease of cattle, the ileal Peyer's patch (IPP) represents the main entry port for the BSE agent. In earlier C-BSE pathogenesis studies, cattle at 4-6 months of age were orally challenged, while there are strong indications that the risk of infection is highest in young animals. In the present study, unweaned calves aged 4-6 weeks were orally challenged to determine the earliest time point at which newly formed PrPBSE and BSE infectivity are detectable in the IPP...
December 19, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29248785/nuclear-model-analysis-of-excitation-functions-of-%C3%AE-particle-induced-reactions-on-in-and-cd-up-to-60mev-with-relevance-to-the-production-of-high-specific-activity-117msn
#13
M N Aslam, K Zubia, S M Qaim
Excitation functions were calculated for the α-particle induced reactions 115In(α,x)117mSn, 114Cd(α,n)117mSn, 116Cd(α,3n)117mSn and natCd(α,x)117mSn to analyse the production of the medically important 117mSn (T½ = 13.6 d). For calculations three nuclear model codes (i.e. TALYS, EMPIRE and ALICE-IPPE) were used and the results were compared with the available experimental data. For the most important reaction, 116Cd(α,3n)117mSn, evaluated data are presented. The yield and radionuclidic purity of 117mSn from each reaction are discussed...
December 5, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29247328/identification-and-cytochemical-immunolocalization-of-acetyl-coa-acetyltransferase-involved-in-the-terpenoid-mevalonate-pathway-in-euphorbia-helioscopia-laticifers
#14
Meng Wang, Dou Wang, Qing Zhang, Jia Chai, Yong Peng, Xia Cai
BACKGROUND: Terpenoids, the largest class of natural products in the plant kingdom, have been widely used in medicine. The precursors of terpenoids, isoprene phosphate (IPP) and dimethylallyl pyrophosphate (DMAPP), were synthesized from a mevalonate (MVA) pathway and a 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway respectively. The acetyl-CoA acetyltransferase (AACT) is the initial enzyme in MVA pathway and is considered presently to be essential for terpenoid backbone biosynthesis...
December 16, 2017: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/29238667/penile-prosthesis-in-the-management-of-erectile-dysfunction-following-cancer-therapy
#15
REVIEW
Pranav Dadhich, Mark Hockenberry, E Will Kirby, Larry Lipshultz
Erectile dysfunction (ED) is a common problem in older men and occurs with even greater frequency following the treatment of pelvic malignancies. Inflatable penile prosthesis (IPP) implantation is a safe and effective form of definitive ED treatment for those men who fail more conservative measures, and it can be used with similar outcomes in men following cancer therapy. Although many of these men remain dissatisfied with other therapeutic options for ED, IPPs are underutilized in this population. This review will discuss the current practice patterns, outcomes and nuances to surgical technique regarding the use of IPPs in patients with ED following cancer therapy...
November 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29238666/preoperative-counseling-and-expectation-management-for-inflatable-penile-prosthesis-implantation
#16
REVIEW
Gopal L Narang, Bradley D Figler, Robert M Coward
The inflatable penile prosthesis (IPP) is the gold standard surgical treatment for medical refractory erectile dysfunction (ED). While the modern IPP has enjoyed high satisfaction rates as a product of its continued innovation, reliability, and performance, patient dissatisfaction can still occur. IPP implantation restores physiologic function with cosmetic and psychological consequences, both of which place inherent emphasis on preoperative counseling and expectation management. This review aims to highlight the complex nature of such counseling and provide practitioners with a roadmap to navigate the landscape...
November 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29238665/penile-implants-a-look-into-the-future
#17
REVIEW
Katherine M Rodriguez, Taylor P Kohn, Anthony B Davis, Tariq S Hakky
Inflatable penile prosthesis (IPP) has been around since the 1970's as a durable and one-time cure for erectile dysfunction (ED). For the past 40 years, many changes have been made to make the device better and currently IPP boasts a high percentage of long-term patient satisfaction. The next paradigm shift in IPP treatment for ED is upon us. Funding for ED related medications and devices has been a hot topic in health policy over the last 10 years. This suggests that the device must improve and patient advocacy and education must increase for IPP to remain as a viable solution for ED...
November 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29238664/a-history-of-penile-implants
#18
REVIEW
Katherine M Rodriguez, Alexander W Pastuszak
Erectile dysfunction (ED) has long been described by physicians and patients, with treatments for ED proposed starting in the 8th century BC. In the last 50 years, however, there have been many advances in medical and surgical management of ED, notably the introduction of the inflatable penile prosthesis (IPP) in 1973 and phosphodiesterase type 5 inhibitors (PDE5Is) in 1998. Here we review the evolution of the IPP from 1973 through the current day. The 3-piece device was first described in 1973 by Dr. F. Brantley Scott, who helped found American Medical Systems (AMS) to market and sell the device...
November 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29238660/salvage-penile-prosthetic-surgery-utilizing-temporary-malleable-implants
#19
REVIEW
Michael Lao, R James Graydon, Jared M Bieniek
The inflatable penile prosthesis (IPP) is an effective erectile dysfunction (ED) treatment modality when oral and injectable therapies fail to achieve satisfactory results. Unfortunately, infection of the prosthetic remains a dreaded complication occurring in a small fraction of patients despite advances in device design and surgical techniques. With a prosthetic infection or erosion, classic management has included removal of all hardware with thorough irrigation of the infected spaces. To prevent corporal fibrosis and scarring that can make a subsequent implant challenging, an immediate salvage procedure with a three-piece prosthesis has been advocated when possible...
November 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29233432/design-and-activity-evaluation-of-an-advanced-introductory-pharmacy-practice-experience-aippe-course-for-assessment-of-student-appe-readiness
#20
Eric Gilliam, Wesley Nuffer, Megan Thompson, Joseph Vande Griend
BACKGROUND AND PURPOSE: The newly implemented Advanced-Introductory Pharmacy Practice Experience (aIPPE) course at the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences was designed to assess student readiness for Advanced Pharmacy Practice Experience (APPE) and provide formative feedback regarding skills and abilities needed to be successful during subsequent coursework and practice experiences. EDUCATIONAL ACTIVITY AND SETTING: The aIPPE is a full-time, six week (240hours) direct patient care rotation occurring in the spring semester of the third-professional year following a longitudinal integrated IPPE program...
July 2017: Currents in Pharmacy Teaching & Learning
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