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https://www.readbyqxmd.com/read/28926242/structure-function-studies-of-artemisia-tridentata-farnesyl-diphosphate-synthase-and-chrysanthemyl-diphosphate-synthase-by-site-directed-mutagenesis-and-morphogenesis
#1
J Scott Lee, Jian-Jung Pan, Gurusankar Ramamoorthy, C Dale Poulter
The amino acid sequences of farnesyl diphosphate synthase (FPPase) and chrysanthemyl diphosphate synthase (CPPase) from Artemisia tridentata ssp. Spiciformis, minus their chloroplast targeting regions, are 71% identical and 90% similar. FPPase efficiently and selectively synthesizes the "regular" sesquiterpenoid farnesyl diphosphate (FPP) by coupling isopentenyl diphosphate (IPP) to dimethylallyl diphosphate (DMAPP) and then to geranyl diphosphate (GPP). In contrast, CPPase is an inefficient promiscuous enzyme, which synthesizes the "irregular" monoterpenes chrysanthemyl diphosphate (CPP), lavandulyl diphosphate (LPP), and trace quantities of maconelliyl diphosphate (MPP) from two molecules of DMAPP, in addition to coupling IPP to DMAPP...
September 19, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28921828/hdl-c-apoa-i-a-multi-vessel-cardiometabolic-risk-marker-in-women-with-t2dm
#2
Michel P Hermans, Paul Valensi, Sylvie A Ahn, Michel F Rousseau
AIMS: Although women have higher HDL-C than men, their HDL particles are also prone to become small, dense and dysfunctional in case of T2DM. To assess the vascular risk related to HDLs of different sizes/densities without direct measurement, we adjusted HDL-C to its main apolipoprotein (apoA-I), as [HDL-C/apoA-I]. This ratio estimates HDLs size and provides indices as to their number, cholesterol load, and density. METHODS: We stratified 280 Caucasian T2DM women according to [HDL-C/apoA-I] quartiles (Q), to determine how it segregates cardiometabolic risk, β-cell function, glycemic control, and vascular complications...
September 15, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28918530/exogenous-and-endogenous-increase-in-fungal-ggpp-increased-fungal-taxol-production
#3
Sameh S M Soliman, Kareem A Mosa, Ali A El-Keblawy, Mohamed I Husseiny
Taxol is an anticancer identified in both endophytic fungus and its host plant. Plant Taxol is a diterpenoid with geranylgeranyl diphosphate (GGPP) mediates the biosynthesis of its terpenoid moiety. Previous report has suggested that fungal Taxol may require terpenoid pathway for its biosynthesis. Here in this study, feeding a Taxol-producing endophytic fungus (Paraconiothyrium SSM001) with terpenoid precursors including isopentenyl pyrophosphate (IPP, isoprene) and GGPP enhanced Taxol production threefold and fivefold, respectively, compared to the control...
September 16, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28913876/an-assessment-of-participant-described-interprofessional-oral-health-referral-systems-across-rurality
#4
Sean G Boynes, Abigail Lauer, Mark Deutchman, Amy B Martin
PURPOSE: As a means to identify and quantify oral health interprofessional collaborative practice (IPP), we examined participant-described medical-to-dental (M2D) referral networks and how they function across rurality. METHODS: We conducted a cross-sectional survey on the appraisal of IPP referral systems in 2016. Secondarily, we examined if rural health clinics (RHCs) have different experiences with M2D referrals compared to other practice types. Independent variables included geographic and organizational indicators, referral system attributes, and respondent characteristics...
September 15, 2017: Journal of Rural Health
https://www.readbyqxmd.com/read/28904895/the-penoscrotal-surgical-approach-for-inflatable-penile-prosthesis-placement
#5
REVIEW
Nikhil K Gupta, Josh Ring, Landon Trost, Steven K Wilson, Tobias S Köhler
Optimizing outcomes with placement of inflatable penile prostheses (IPPs) can be challenging, especially in inexperienced hands. In this article, we outline Dr. Köhler's penoscrotal penile prosthesis surgical approach. We also highlight patient selection, post-operative care and complications.
August 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28902970/a-genetic-screen-in-rodent-malaria-parasites-identifies-five-new-apicoplast-putative-membrane-transporters-one-of-which-is-essential-in-human-malaria-parasites
#6
Claire P Sayers, Vanessa Mollard, Hayley D Buchanan, Geoffrey I McFadden, Christopher D Goodman
The malaria-causing parasite, Plasmodium, contains a unique non-photosynthetic plastid known as the apicoplast. The apicoplast is an essential organelle bound by four membranes. Although membrane transporters are attractive drug targets, only two transporters have been characterised in the malaria parasite apicoplast membranes. We selected 27 candidate apicoplast membrane proteins, 20 of which are annotated as putative membrane transporters, and performed a genetic screen in P. berghei to determine blood stage essentiality and subcellular localisation...
September 13, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28900123/effects-of-low-intraperitoneal-pressure-and-a-warmed-humidified-carbon-dioxide-gas-in-laparoscopic-surgery-a-randomized-clinical-trial
#7
Sachiko Matsuzaki, Lise Vernis, Martine Bonnin, Celine Houlle, Aurelie Fournet-Fayard, Giuseppe Rosano, Anne Laure Lafaye, Christian Chartier, Agnes Barriere, Brigitte Storme, Jean-Etienne Bazin, Michel Canis, Revaz Botchorishvili
Laparoscopic surgery technology continues to advance. However, much less attention has been focused on how alteration of the laparoscopic surgical environment might improve clinical outcomes. We conducted a randomized, 2 × 2 factorial trial to evaluate whether low intraperitoneal pressure (IPP) (8 mmHg) and/or warmed, humidified CO2 (WH) gas are better for minimizing the adverse impact of a CO2 pneumoperitoneum on the peritoneal environment during laparoscopic surgery and for improving clinical outcomes compared to the standard IPP (12 mmHg) and/or cool and dry CO2 (CD) gas...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28886994/successful-treatment-of-residual-curvature-in-peyronie-s-disease-in-men-previously-treated-with-intralesional-collagenase-clostridium-histolyticum
#8
Kenneth DeLay, Linley Diao, Hoang M T Nguyen, Jonathan Zurawin, Russell Libby, Faysal Yafi, Wayne J G Hellstrom
OBJECTIVE: To determine the success and feasibility of surgically correcting residual curvature after intralesional collagenase Clostridium histolyticum (CCH) for the treatment of Peyronie's disease. METHODS: We performed a retrospective analysis of patients who had intralesional CCH treatment for (PD) and who subsequently underwent penile plication (PP), plaque incision and grafting (PIG), or inflatable penile prosthesis (IPP) placement. RESULTS: Ten men who underwent PP, PIG, or IPP for the treatment of residual curvature after intralesional CCH were identified...
September 5, 2017: Urology
https://www.readbyqxmd.com/read/28874326/ambicor-two-piece-inflatable-penile-prosthesis-background-and-contemporary-outcomes
#9
REVIEW
Oliver S Ko, Nelson E Bennett
INTRODUCTION: The two-piece inflatable penile prosthesis (IPP; Ambicor) might be a preferred option for men with erectile dysfunction (ED) who have significant retroperitoneal scarring, limited manual dexterity, or other issues. There are reported differences in outcomes and patient and partner satisfaction between three-piece and two-piece IPPs. AIM: To report contemporary outcomes, patient and partner satisfaction, and mechanical durability data of the two-piece compared with the three-piece IPP...
September 2, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28872764/association-between-metabolic-syndrome-and-intravesical-prostatic-protrusion-in-benign-prostatic-enlargement-patients-with-lower-urinary-tract-symptoms-mips-study
#10
G I Russo, F Regis, P Spatafora, J Frizzi, D Urzì, S Cimino, S Serni, M Carini, M Gacci, G Morgia
OBJECTIVE: To investigate the association between metabolic syndrome (MetS) and morphological features of benign prostatic enlargement (BPE), including total prostate volume (TPV), transitional zone volume (TZV) and intra vesical prostatic protrusion (IPP). PATIENTS AND METHODS: From January 2015 to January 2017, 224 consecutive men older than 50 years presenting with lower urinary tract symptoms (LUTS) suggestive of BPE were recruited in this multicentre cross-sectional study...
September 5, 2017: BJU International
https://www.readbyqxmd.com/read/28869407/characterization-of-feedback-resistant-mevalonate-kinases-from-the-methanogenic-archaeons-methanosaeta-concilii-and-methanocella-paludicola
#11
Ekaterina Kazieva, Yoko Yamamoto, Yoshinori Tajima, Keiichi Yokoyama, Joanna Katashkina, Yousuke Nishio
The inhibition of mevalonate kinase (MVK) by downstream metabolites is an important mechanism in the regulation of isoprenoid production in a broad range of organisms. The first feedback-resistant MVK was previously discovered in the methanogenic archaeon Methanosarcinamazei. Here, we report the cloning, expression, purification, kinetic characterization and inhibition analysis of MVKs from two other methanogens, Methanosaetaconcilii and Methanocellapaludicola. Similar to the M. mazei MVK, these enzymes were not inhibited by diphosphomevalonate (DPM), dimethylallyl diphosphate (DMAPP), isopentenyldiphosphate (IPP), geranylpyrophosphate (GPP) or farnesylpyrophosphate (FPP)...
September 4, 2017: Microbiology
https://www.readbyqxmd.com/read/28868600/a-pleural-vacuum-relief-device-for-pleural-drain-unit-use-in-the-hyperbaric-environment
#12
Marco Gelsomino, Theo Tsouras, Ian Millar, Andrew Fock
INTRODUCTION: When a standard water-seal pleural drain unit (PDU) is used under hyperbaric conditions there are scenarios where excessive negative intrapleural pressure (IPP) and/or fluid reflux can be induced, risking significant morbidity. We developed and tested a pleural vacuum relief (PVR) device which automatically manages these risks, whilst allowing more rapid hyperbaric pressure change rates. METHODS: The custom-made PVR device consists of a one-way pressure relief valve connected in line with a sterile micro filter selected for its specific flow capacity...
September 2017: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/28862889/best-practice-interprofessional-stroke-care-collaboration-and-simulation-the-student-perspective
#13
Diane MacKenzie, Gail Creaser, Kim Sponagle, Gordon Gubitz, Peter MacDougall, Dylan Blacquiere, Stephen Miller, Gordon Sarty
Interprofessional practice (IPP) is the accepted standard of care for clients following a stroke. A brief, embedded and evidence-based IPP team simulation was designed to address stroke care knowledge and IPP competencies for students within limited curriculum space. Each team was required to construct a collaborative care plan for their patient during the simulation and submit the care plan for evaluation of best practice stroke care knowledge and implementation with evidence of interprofessional collaboration (IPC)...
September 1, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28861938/diagnostic-accuracy-of-a-new-algorithm-to-detect-atrial-fibrillation-in-a-home-blood-pressure-monitor
#14
Tomoyuki Kabutoya, Yasushi Imai, Satoshi Hoshide, Kazuomi Kario
The authors evaluated a new algorithm for detecting atrial fibrillation (AF) using a home blood pressure monitor. Three serial blood pressure values were measured by the monitor in 16 patients with AF and 20 patients with sinus rhythm. The authors defined "monitor AF in irregular pulse peak (IPP) 25" as follows: (1) IPP: |interval of pulse peak - the average of the interval of the pulse peak| ≥ the average of the interval of the pulse peak ×25%; (2) irregular heart beat: beats of IPP ≥ total pulse ×20%; and (3) monitor AF: two or more irregular heart beats of the three blood pressure measurements...
September 1, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28859871/-stiction-syndrome-non-operative-management-of-patients-with-difficult-ams-700-series-inflation
#15
Nicholas L Kavoussi, Boyd R Viers, Maia E VanDyke, Travis J Pagliara, Allen F Morey
INTRODUCTION: Static friction (stiction) is a mechanical phenomenon in which a state of increased resistance exists across a control valve mechanism. AIM: To present a strategy for non-operative management of inflatable penile prosthesis (IPP) cases with pump malfunction from pump valve stiction. METHODS: All patients had American Medical Systems (AMS; Minnetonka, MN, USA) 700 series Momentary Squeeze IPPs with transient pump malfunction owing to pump valve stiction after extended periods of device inactivity...
September 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28854674/increasing-the-intracellular-isoprenoid-pool-in-saccharomyces-cerevisiae-by-structural-fine-tuning-of-a-bifunctional-farnesyl-diphosphate-synthase
#16
Sebastián Rubat, Ignacio Varas, Romina Sepúlveda, Daniel Almonacid, Fernando González-Nilo, Eduardo Agosin
Farnesyl diphosphate synthase (FPPS) is a key enzyme responsible for the supply of isoprenoid precursors for several essential metabolites, including sterols, dolichols and ubiquinone. In Saccharomyces cerevisiae, FPPS catalyzes the sequential condensation of two molecules of isopentenyl diphosphate (IPP) with dimethylallyl diphosphate (DMAPP), producing geranyl diphosphate (GPP) and farnesyl diphosphate (FPP). Critical amino acid residues that determine product chain length were determined by a comparative study of strict GPP synthases versus strict FPPS...
June 1, 2017: FEMS Yeast Research
https://www.readbyqxmd.com/read/28817505/the-effects-of-the-gaa15-on-lower-extremity-injury-incidence-and-neuromuscular-functional-outcomes-in-collegiate-gaelic-games
#17
Brenagh E Schlingermann, Clare A Lodge, Conor Gissane, Paula M Rankin
The purpose of this Observational Analytical Cohort Study was to assess the effectiveness of an injury prevention programme (IPP) - GAA15 (Gaelic Athletic Association 15) - on the incidence of injury in collegiate Gaelic games. 131 Gaelic games players (mean age 20.5 years ± SD 3.0) were used for analysis in this study. Participants completed preseason and postseason testing which involved performance of the Y Balance test. The GAA15 was employed for the intervention group; coaches were instructed to implement the programme before every training session and match throughout the collegiate GAA (Gaelic Athletic Association) season...
July 5, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28810925/surgical-versus-percutaneous-isolated-pelvic-perfusion-ipp-for-advanced-melanoma-comparison-in-terms-of-melphalan-pharmacokinetic-pelvic-bio-availability
#18
Stefano Guadagni, Giancarlo Palumbo, Giammaria Fiorentini, Marco Clementi, Luca Marsili, Aldo Victor Giordano, Francesco Masedu, Marco Valenti
BACKGROUND: Isolated pelvic perfusion (IPP) can be used to treat unresectable melanoma metastases of the pelvis. IPP can be performed either by surgical or percutaneous approaches, using different balloon catheters. The aim of this study was to examine whether the surgical and percutaneous approaches were comparable with respect to tumor drug exposure in the pelvis. METHODS: A pharmacokinetic study was performed in 5 melanoma patients treated with surgical IPP and five with percutaneous IPP...
August 15, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28809830/overexpression-and-purification-of-human-cis-prenyltransferase-in-escherichia-coli
#19
Ilan Edri, Michal Goldenberg, Michal Lisnyansky, Roi Strulovich, Hadas Newman, Anat Loewenstein, Daniel Khananshvili, Moshe Giladi, Yoni Haitin
Prenyltransferases (PT) are a group of enzymes that catalyze chain elongation of allylic diphosphate using isopentenyl diphosphate (IPP) via multiple condensation reactions. DHDDS (dehydrodolichyl diphosphate synthase) is a eukaryotic long-chain cis-PT (forming cis double bonds from the condensation reaction) that catalyzes chain elongation of farnesyl diphosphate (FPP, an allylic diphosphate) via multiple condensations with isopentenyl diphosphate (IPP). DHDDS is of biomedical importance, as a non-conservative mutation (K42E) in the enzyme results in retinitis pigmentosa, ultimately leading to blindness...
August 3, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28805728/nano-charged-polypropylene-application-realistic-perspectives-for-enhancing-durability
#20
Carlo Naddeo, Luigi Vertuccio, Giuseppina Barra, Liberata Guadagno
Isotactic polypropylene/multi-walled carbon nanotube (iPP/MWCNTs) films have been exposed to accelerated weathering in a UV device for increasing times. The effect of UV irradiation on the structural and chemical changes has been investigated. The resistance to accelerated photooxidation of (iPP/MWCNTs) films has been compared to the photooxidation behaviour of unfilled polypropylene films with the same structural organization. The chemical and structural modifications resulting from photooxidation have been followed using infrared spectroscopy, calorimetric and diffractometric analysis...
August 14, 2017: Materials
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