keyword
https://read.qxmd.com/read/38530827/use-of-a-health-worker-targeted-smartphone-app-to-support-quality-malaria-rdt-implementation-in-busia-county-kenya-a-feasibility-and-acceptability-study
#21
JOURNAL ARTICLE
Malia Skjefte, Shawna Cooper, Stephen Poyer, Christopher Lourenço, Sam Smedinghoff, Brett Keller, Tonny Wambua, Christine Oduor, Sasha Frade, Wycliffe Waweru
Malaria rapid diagnostic tests (mRDTs) are an essential diagnostic tool in low-resource settings; however, administration and interpretation errors reduce their effectiveness. HealthPulse, a smartphone mRDT reader application, was developed by Audere to aid health workers in mRDT administration and interpretation, with an aim to improve the mRDT testing process and facilitate timely decision making through access to digitized results. Audere partnered with PSI and PS Kenya to conduct a pilot study in Busia County, Kenya between March and September 2021 to assess the feasibility and acceptability of HealthPulse to support malaria parasitological diagnosis by community health volunteers (CHVs) and private clinic health workers (private clinic HWs)...
2024: PloS One
https://read.qxmd.com/read/38530596/developing-a-program-costs-checklist-of-digital-health-interventions-a-scoping-review-and-empirical-case-study
#22
JOURNAL ARTICLE
Zareen Abbas Khan, Kristian Kidholm, Sindre Andre Pedersen, Silje Marie Haga, Filip Drozd, Thea Sundrehagen, Ellen Olavesen, Vidar Halsteinli
INTRODUCTION: The rate of development and complexity of digital health interventions (DHIs) in recent years has to some extent outpaced the methodological development in economic evaluation and costing. Particularly, the choice of cost components included in intervention or program costs of DHIs have received scant attention. The aim of this study was to build a literature-informed checklist of program cost components of DHIs. The checklist was next tested by applying it to an empirical case, Mamma Mia, a DHI developed to prevent perinatal depression...
March 26, 2024: PharmacoEconomics
https://read.qxmd.com/read/38529954/efficacy-of-a-digital-diabetes-logbook-for-people-with-type-1-type-2-and-gestational-diabetes-results-from-a-multicenter-open-label-parallel-group-randomized-controlled-trial
#23
JOURNAL ARTICLE
Dominic Ehrmann, Norbert Hermanns, Katharina Finke-Gröne, Timm Roos, Johanna Kober, Vanessa Schäfer, Michael Krichbaum, Thomas Haak, Ralph Ziegler, Lutz Heinemann, Cosima Rieger, Ezgi Bingol, Bernhard Kulzer, Stephan Silbermann
BACKGROUND: In a randomized controlled trial, the efficacy of a digital diabetes diary regarding a reduction of diabetes distress was evaluated. METHODS: A randomized controlled trial with a 12-week follow-up was conducted in 41 study sites across Germany. Key eligibility criteria were a diagnosis of type 1, type 2, or gestational diabetes and regular self-monitoring of blood glucose. Participants were randomly assigned (2:1 ratio) to either use the digital diabetes logbook (mySugr PRO), or to the control group without app use...
March 26, 2024: Journal of Diabetes Science and Technology
https://read.qxmd.com/read/38529732/functional-size-measurement-of-postnatal-care-apps-morocco-case-study
#24
JOURNAL ARTICLE
Karima Moumane, Lamyae Sardi, Ali Idri, Alain Abran
This study empirically evaluates the functionality coverage of 18 mobile applications (apps) for Postnatal care including a recently developed app in Morocco " Mamma&Baby" . This evaluation is based on a comparison of the COSMIC _ISO 19,761 functional size of these apps with the score obtained in a previous evaluation based on functions extraction through a quality assessment questionnaire. This comparison allows to discuss the relationship between the functional size of the 18 apps, their users' ratings in the Play Store as well as the number of downloads...
March 26, 2024: Informatics for Health & Social Care
https://read.qxmd.com/read/38529731/old-age-or-cognitive-decline-examining-the-usability-of-a-mobile-health-app-for-older-australians
#25
JOURNAL ARTICLE
Breda McCarthy, Jagdeep Kaur Sabharwal, Shailey Chawla
There is a growing literature on the role of mobile health applications (mHealth apps) in supporting older adults and the self-management of personal health. The purpose of this pilot study is to assess the usability of a government-funded mobile health app amongst older Australians and to evaluate whether cognitive function and demographic characteristics (i.e. age, gender, education) are associated with usability. A total of 28 older adults living in a regional city in Australia took part in the study. The participants were recruited using purposive sampling...
March 26, 2024: Informatics for Health & Social Care
https://read.qxmd.com/read/38529687/the-feasibility-and-acceptability-of-an-app-based-intervention-with-brief-behavioural-support-approach-to-promote-brisk-walking-in-people-diagnosed-with-breast-prostate-and-colorectal-cancer-in-the-uk
#26
JOURNAL ARTICLE
Phillippa Lally, Fiona Kennedy, Susan Smith, Rebecca J Beeken, Caroline Buck, Chloe Thomas, Nicholas Counsell, Lynda Wyld, Charlene Martin, Sarah Williams, Anna Roberts, Diana M Greenfield, Jacqui Gath, Henry W W Potts, Nicholas Latimer, Lee Smith, Abi Fisher
INTRODUCTION: Increased moderate to vigorous physical activity (MVPA) can improve clinical and psychosocial outcomes for people living with and beyond cancer (LWBC). This study aimed to assess the feasibility and acceptability of trial procedures in a pilot randomised controlled trial (RCT) of a theory-driven app-based intervention with behavioural support focused on promoting brisk walking (a form of MVPA) in people LWBC (APPROACH). METHODS: Participants diagnosed with breast, prostate or colorectal cancer were recruited from a single UK hospital site...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38528967/a-content-based-review-of-mobile-health-applications-for-breast-cancer-prevention-and-education-characteristics-quality-and-functionality-analysis
#27
REVIEW
Stefanie Altmannshofer, Madeleine Flaucher, Milena Beierlein, Bjoern M Eskofier, Matthias W Beckmann, Peter A Fasching, Hanna Huebner
OBJECTIVE: Mobile Health apps could be a feasible and effective tool to raise awareness for breast cancer prevention and to support women to change their behaviour to a healthier lifestyle. The aim of this study was to analyse the characteristics and quality of apps designed for breast cancer prevention and education. METHODS: We conducted a systematic search for apps covering breast cancer prevention topics in the Google Play and Apple App Store accessible from Germany using search terms either in German or in English...
2024: Digital Health
https://read.qxmd.com/read/38528836/spatial-temporal-mapping-reveals-the-golgi-as-the-major-processing-site-for-the-pathogenic-swedish-app-mutation-familial-app-mutant-shifts-the-major-app-processing-site
#28
JOURNAL ARTICLE
Jingqi Wang, Paul A Gleeson, Lou Fourriere
Alzheimer's disease is associated with increased levels of amyloid beta (Aβ) generated by sequential intracellular cleavage of amyloid precursor protein (APP) by membrane-bound secretases. However, the spatial and temporal APP cleavage events along the trafficking pathways are poorly defined. Here, we use the Retention Using Selective Hooks (RUSH) to compare in real time the anterograde trafficking and temporal cleavage events of wild-type APP (APPwt) with the pathogenic Swedish APP (APPswe) and the disease-protective Icelandic APP (APPice)...
March 2024: Traffic
https://read.qxmd.com/read/38528501/newly-discovered-clouting-interplay-between-matrix-metalloproteinases-structures-and-novel-quaternary-ammonium-k21-computational-and-in-vivo-testing
#29
JOURNAL ARTICLE
Ranjeet Ajit Bapat, Kit-Kay Mak, Mallikarjuna Rao Pichika, Jia Chern Pang, Seow Liang Lin, Suan Phaik Khoo, Umer Daood
AIMS AND OBJECTIVES: To analyze anti-MMP mode of action of Quaternary Ammonium Silane (QAS, codenamed as k21) by binding onto specific MMP site using computational molecular simulation and Anti-Sortase A (SrtA) mode of action by binding onto specific site using computational molecular simulation. MATERIALS AND METHODS: In silico Molecular Dynamics (MD) was used to determine the interactions of K21 inside the pocket of the targeted protein (crystal structure of fibroblast collagenase-1 complexed to a diphenyl-ether sulphone based hydroxamic acid; PDB ID: 966C; Crystal structure of MMP-2 active site mutant in complex with APP-derived decapeptide inhibitor...
March 25, 2024: BMC Oral Health
https://read.qxmd.com/read/38528452/design-and-usability-evaluation-of-a-mobile-application-for-self-care-among-iranian-adolescents
#30
JOURNAL ARTICLE
Razieh Rezaee, Mohtasham Ghaffari, Reza Rabiei, Amir Kavousi, Sakineh Rakhshanderou
BACKGROUND: Mobile phones can be an ideal platform to engage adolescents to maintain, improve, and promote self-care. Therefore, the current study aims to design and evaluate the usability of a mobile application for self-care in adolescents with a user-centered approach. METHODS: The current applied developmental study was done in four steps. The first step, polling and examining opinions was conducted through in-depth semi-structured interviews, with the aim of user-centered mobile application design with the involvement of 30 participants...
March 25, 2024: BMC Public Health
https://read.qxmd.com/read/38528305/circ-bptf-ameliorates-learning-and-memory-impairments-via-the-mir-138-5p-p62-axis-in-app-ps1-mice
#31
JOURNAL ARTICLE
Hong-Fang Wang, Yi-Bo Li, Zi-Yu Liu, Wen-Meng Xie, Qing Liu, Run-Jiao Zhang, Wen-Yu Wang, Jia-Xin Hao, Lei Wang, Dan-Dan Geng
Alzheimer's disease (AD) is a common age-associated progressive neurodegenerative disorder that is implicated in the aberrant regulation of numerous circular RNAs (circRNAs). Here, we reported that circ-Bptf, a conserved circRNA derived from the Bptf gene, showed an age-dependent decrease in the hippocampus of APP/PS1 mice. Overexpression of circ-Bptf significantly reversed dendritic spine loss and learning and memory impairment in APP/PS1 mice. Moreover, we found that circ-Bptf was predominantly localized to the cytoplasm and upregulated p62 expression by binding to miR-138-5p...
March 25, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38527997/phenome-wide-mendelian-randomisation-analysis-of-378-142-cases-reveals-risk-factors-for-eight-common-cancers
#32
JOURNAL ARTICLE
Molly Went, Amit Sud, Charlie Mills, Abi Hyde, Richard Culliford, Philip Law, Jayaram Vijayakrishnan, Ines Gockel, Carlo Maj, Johannes Schumacher, Claire Palles, Martin Kaiser, Richard Houlston
For many cancers there are only a few well-established risk factors. Here, we use summary data from genome-wide association studies (GWAS) in a Mendelian randomisation (MR) phenome-wide association study (PheWAS) to identify potentially causal relationships for over 3,000 traits. Our outcome datasets comprise 378,142 cases across breast, prostate, colorectal, lung, endometrial, oesophageal, renal, and ovarian cancers, as well as 485,715 controls. We complement this analysis by systematically mining the literature space for supporting evidence...
March 25, 2024: Nature Communications
https://read.qxmd.com/read/38527856/app-antisense-oligonucleotides-reduce-a%C3%AE-aggregation-and-rescue-endolysosomal-dysfunction-in-alzheimer-s-disease
#33
JOURNAL ARTICLE
Christy Hung, Emre Fertan, Frederick J Livesey, David Klenerman, Rickie Patani
APP gene dosage is strongly associated with Alzheimer's disease (AD) pathogenesis. Genomic duplication of the APP locus leads to autosomal dominant early-onset AD. Individuals with Down syndrome (trisomy of chromosome 21) harbor 3 copies of the APP gene and invariably develop progressive AD with highly characteristic neuropathological features. Restoring expression of APP to the equivalent of that of two gene copies, or lower, is a rational therapeutic strategy, as it would restore physiological levels of neuronal APP protein without the potentially deleterious consequences of inadvertently inducing loss of APP function...
March 25, 2024: Brain
https://read.qxmd.com/read/38527337/imageassist-a-novel-smartphone-application-for-standardized-clinical-photography-that-implements-and-automates-american-society-of-plastic-surgery-plastic-surgery-foundation-photographic-guidelines-with-background-deletion
#34
JOURNAL ARTICLE
Michael S Golinko, Odette Abou-Ghanem, Michael Simard, Mike Caudill, Matthew E Pontell, Nick O'Sick, Brandon Oglesby, Mark Arrieta
STATEMENT OF THE PROBLEM: Standardized medical photography of the face is a vital part of patient documentation, clinical evaluation, and scholarly dissemination. Because digital photography is a mainstay in clinical care, there is a critical need for an easy-to-use mobile device application that could assist users in taking a standardized clinical photograph. ImageAssist was developed to answer this need. The mobile application is integrated into the electronic medical record (EMR); it implements and automates American Society of Plastic Surgery/Plastic Surgery Research Foundation photographic guidelines with background deletion...
April 1, 2024: Annals of Plastic Surgery
https://read.qxmd.com/read/38527280/stability-over-time-of-word-syllable-duration-for-speakers-with-acquired-apraxia-of-speech
#35
JOURNAL ARTICLE
Lisa D Bunker, Dallin J Bailey, Elaine Poss, Shannon Mauszycki, Julie L Wambaugh
PURPOSE: Neurogenic speech and language disorders-such as acquired apraxia of speech (AOS) and aphasia with phonemic paraphasia (APP)-are often misdiagnosed due to similarities in clinical presentation. Word syllable duration (WSD)-a measure of average syllable length in multisyllabic words-serves as a proxy for speech rate, which is an important and arguably more objective clinical characteristic of AOS and APP. This study reports stability of WSD over time for speakers with AOS (and aphasia)...
March 25, 2024: Journal of Speech, Language, and Hearing Research: JSLHR
https://read.qxmd.com/read/38527090/designing-development-and-validation-of-an-app-to-reduce-the-response-time-of-the-emergency-medical-services
#36
JOURNAL ARTICLE
Júlia Loverde Gabella, Iago Amado Peres Gualda, Isadora Laguila Altoé, Matheus Henrique Arruda Beltrame, Pedro Henrique Aguillar da Silva, Dalton Breno Costa, Fernando César Grossi Paggi, Sérgio Sanches Fabres Filho, Miyoko Massago, Luiz Gustavo de Paulo, Marcos Rogério Bitencourt, Anjni Patel Joiner, João Ricardo Nickenig Vissoci, Luciano de Andrade
INTRODUCTION: Delays in prehospital care attributable to the call-taking process can often be traced back to miscommunication, including uncertainty around the call location. Geolocation applications have the potential to streamline the call-taking process by accurately identifying the caller's location. OBJECTIVE: To develop and validate an application to geolocate emergency calls and compare the response time of calls made via the application with those of conventional calls made to the Brazilian Medical Emergency System (Serviço de Atendimento Médico de Urgência-SAMU)...
2024: PloS One
https://read.qxmd.com/read/38527062/hippo-signaling-controlled-mhc-class-i-antigen-processing-and-presentation-pathway-potentiates-antitumor-immunity
#37
JOURNAL ARTICLE
Linyuan Peng, Liang Zhou, Huan Li, Xin Zhang, Su Li, Kai Wang, Mei Yang, Xiaoyu Ma, Danlan Zhang, Siliang Xiang, Yajun Duan, Tianzhi Wang, Chunmeng Sun, Chen Wang, Desheng Lu, Minxian Qian, Zhongyuan Wang
The major histocompatibility complex class I (MHC class I)-mediated tumor antigen processing and presentation (APP) pathway is essential for the recruitment and activation of cytotoxic CD8+ T lymphocytes (CD8+ CTLs). However, this pathway is frequently dysregulated in many cancers, thus leading to a failure of immunotherapy. Here, we report that activation of the tumor-intrinsic Hippo pathway positively correlates with the expression of MHC class I APP genes and the abundance of CD8+ CTLs in mouse tumors and patients...
March 23, 2024: Cell Reports
https://read.qxmd.com/read/38526813/-secondary-fracture-prevention-update-osteoporosis-guidelines-2023-of-the-umbrella-organization-osteology
#38
REVIEW
Ulla Stumpf, Ralf Schmidmaier
The S3 guidelines on the prophylaxis, diagnostics and treatment of osteoporosis 2023 were completely revised and updated between 2021 and 2023 in accordance with the Association of the Scientific Medical Societies of Germany (AWMF) regulations. The guideline committee consisted of delegates from the 20 specialist societies of the Umbrella Organization Osteology (Dachverband Osteologie, DVO) as well as delegates from the German Society of General Medicine and Family Medicine (DEGAM), the German Society for Nephrology (DGfN) and the Federal Self-help Association for Osteoporosis (BfO)...
April 2024: Unfallchirurgie (Heidelb)
https://read.qxmd.com/read/38526539/personalized-ai-driven-real-time-models-to-predict-stress-induced-blood-pressure-spikes-using-wearable-devices-proposal-for-a-prospective-cohort-study
#39
JOURNAL ARTICLE
Ali Kargarandehkordi, Christopher Slade, Peter Washington
BACKGROUND: Referred to as the "silent killer," elevated blood pressure (BP) often goes unnoticed due to the absence of apparent symptoms, resulting in cumulative harm over time. Chronic stress has been consistently linked to increased BP. Prior studies have found that elevated BP often arises due to a stressful lifestyle, although the effect of exact stressors varies drastically between individuals. The heterogeneous nature of both the stress and BP response to a multitude of lifestyle decisions can make it difficult if not impossible to pinpoint the most deleterious behaviors using the traditional mechanism of clinical interviews...
March 25, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38525994/substrate-selection-criteria-in-regulated-intramembrane-proteolysis
#40
REVIEW
Celine Moser, Nadja Guschtschin-Schmidt, Mara Silber, Julia Flum, Claudia Muhle-Goll
Alzheimer's disease is the most common form of dementia encountered in an aging population. Characteristic amyloid deposits of Aβ peptides in the brain are generated through cleavage of amyloid precursor protein (APP) by γ-secretase, an intramembrane protease. Cryo-EM structures of substrate γ-secretase complexes revealed details of the process, but how substrates are recognized and enter the catalytic site is still largely ignored. γ-Secretase cleaves a diverse range of substrate sequences without a common consensus sequence, but strikingly, single point mutations within the transmembrane domain (TMD) of specific substrates may greatly affect cleavage efficiencies...
March 25, 2024: ACS Chemical Neuroscience
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