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https://www.readbyqxmd.com/read/29457760/a-systematic-review-of-serious-games-in-medical-education-quality-of-evidence-and-pedagogical-strategy
#1
Iouri Gorbanev, Sandra Agudelo-Londoño, Rafael A González, Ariel Cortes, Alexandra Pomares, Vivian Delgadillo, Francisco J Yepes, Óscar Muñoz
INTRODUCTION: The literature shows an optimistic landscape for the effectiveness of games in medical education. Nevertheless, games are not considered mainstream material in medical teaching. Two research questions that arise are the following: What pedagogical strategies do developers use when creating games for medical education? And what is the quality of the evidence on the effectiveness of games? METHODS: A systematic review was made by a multi-disciplinary team of researchers following the Cochrane Collaboration Guidelines...
December 2018: Medical Education Online
https://www.readbyqxmd.com/read/29456436/learning-activity-predictors-from-sensor-data-algorithms-evaluation-and-applications
#2
Bryan Minor, Janardhan Rao Doppa, Diane J Cook
Recent progress in Internet of Things (IoT) platforms has allowed us to collect large amounts of sensing data. However, there are significant challenges in converting this large-scale sensing data into decisions for real-world applications. Motivated by applications like health monitoring and intervention and home automation we consider a novel problem called Activity Prediction , where the goal is to predict future activity occurrence times from sensor data. In this paper, we make three main contributions...
December 1, 2017: IEEE Transactions on Knowledge and Data Engineering
https://www.readbyqxmd.com/read/29456125/development-and-validation-of-a-tool-to-measure-dietitians-self-efficacy-with-using-mobile-health-apps-in-dietetic-practice
#3
Juliana Chen, Margaret Allman-Farinelli
OBJECTIVE: To develop and validate a tool for assessing dietitians' self-efficacy with using mobile health (mHealth) apps in dietetic practice. DESIGN AND PARTICIPANTS: A tool for measuring mHealth app self-efficacy among dietitians was constructed based on a literature review, consultation with experts, and Bandura's self-efficacy scales development guide. Senior dietetic students and new graduate dietitians in Australia (n = 100) tested the tool. OUTCOME MEASURES AND ANALYSIS: Validation of the tool was conducted using factor analysis...
February 15, 2018: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/29455722/computer-assisted-motivational-interviewing-intervention-to-facilitate-teen-pregnancy-prevention-and-fitness-behavior-changes-a-randomized-trial-for-young-men
#4
David L Bell, Samantha Garbers, Marina Catallozzi, R Stanley Hum, Meredith Nechitilo, Ian W McKeague, Emilia H Koumans, L Duane House, Susan L Rosenthal, Melanie A Gold
PURPOSE: Despite recent declines, teen unintended pregnancy and sexually transmitted infections in the United States remain at levels higher than comparable nations. Initiatives to prevent teen pregnancy have focused primarily on female adolescents; how to effectively engage young men to reduce their risk of fathering a teen pregnancy has not been well studied. We proposed to adapt an innovative computer-assisted motivational interviewing (CAMI) intervention, originally designed and tested with young women, for use with young men, aged 15-24 years, to reduce their risk of fathering a teen pregnancy...
March 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29455155/newly-designed-11-gene-panel-reveals-first-case-of-hereditary-amyloidosis-captured-by-massive-parallel-sequencing
#5
Zuzana Chyra Kufova, Tereza Sevcikova, Jaroslav Januska, Petr Vojta, Arpad Boday, Pavla Vanickova, Jana Filipova, Katerina Growkova, Tomas Jelinek, Marian Hajduch, Roman Hajek
AIMS: Amyloidosis is caused by deposition of abnormal protein fibrils, leading to damage of organ function. Hereditary amyloidosis represents a monogenic disease caused by germline mutations in 11 amyloidogenic precursor protein genes. One of the important but non-specific symptoms of amyloidosis is hypertrophic cardiomyopathy. Diagnostics of hereditary amyloidosis is complicated and the real cause can remain overlooked. We aimed to design hereditary amyloidosis gene panel and to introduce new next-generation sequencing (NGS) approach to investigate hereditary amyloidosis in a cohort of patients with hypertrophic cardiomyopathy of unknown significance...
February 17, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29454265/supplementation-of-lycopene-attenuates-lipopolysaccharide-induced-amyloidogenesis-and-cognitive-impairments-via-mediating-neuroinflammation-and-oxidative-stress
#6
Jia Wang, Lixia Li, Zhuo Wang, Yifan Cui, Xintong Tan, Tian Yuan, Qian Liu, Zhigang Liu, Xuebo Liu
Neuroinflammation is documented to be the major culprit of Alzheimer's disease. Lycopene (LYC), a fat soluble carotenoid, exhibits neuroprotective function in several neurodegenerative disorders. However, the effects of LYC to countering systemic inflammation-induced amyloidogenesis and memory deficiency remain to be elucidated. In current study, 3-month-old male C57BL/6J mice were treated with 0.03% LYC (w/w, mixed into normal chow) for 5 weeks. The mice were then treated by intraperitoneal injection of LPS (0...
February 2, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29454025/early-alteration-of-distribution-and-activity-of-hippocampal-type-1-cannabinoid-receptor-in-alzheimer-s-disease-like-mice-overexpressing-the-human-mutant-amyloid-precursor-protein
#7
Mauro Maccarrone, Antonio Totaro, Alessandro Leuti, Giacomo Giacovazzo, Lucia Scipioni, Dalila Mango, Roberto Coccurello, Robert Nisticò, Sergio Oddi
Besides its involvement in Alzheimer's disease (AD) as precursor of the neurotoxic amyloid peptides, the pathophysiological impact of brain accumulation of amyloid precursor protein (APP) is not yet well understood. Recent studies reported that APP interacts with other membrane proteins, including G protein coupled receptors, affecting their biological functions. Here, we focused on the study of the potential impact of human mutant APP on expression, distribution and activity of type-1 cannabinoid (CB 1 ) receptor in the hippocampus of Tg2576 mice, an AD-like mice model...
February 14, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29452392/pbrit-gene-prioritization-by-correlating-functional-and-phenotypic-annotations-through-integrative-data-fusion
#8
Ajay Anand Kumar, Lut Van Laer, Maaike Alaerts, Amin Ardeshirdavani, Yves Moreau, Kris Laukens, Bart Loeys, Geert Vandeweyer, Inanc Birol
Motivation: Computational gene prioritization can aid in disease gene identification. Here, we propose pBRIT (prioritization using Bayesian Ridge regression and Information Theoretic model), a novel adaptive and scalable prioritization tool, integrating Pubmed abstracts, Gene Ontology, Sequence similarities, Mammalian and Human Phenotype Ontology, Pathway, Interactions, Disease Ontology, Gene Association database and Human Genome Epidemiology database, into the prediction model.We explore and address effects of sparsity and inter-feature dependencies within annotation sources, and the impact of bias towards specific annotations...
February 14, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29452025/subgrouping-the-users-of-a-specialized-app-for-eating-disorders
#9
Shiri Sadeh-Sharvit, Jane Paik Kim, Alison M Darcy, Eric Neri, Molly Vierhile, Athena Robinson, Jenna Tregarthen, James D Lock
Although mobile technologies for eating disorders (EDs) are burgeoning, there is limited data about the clinical characteristics of individuals using specialized smartphone applications (apps) without accompanying traditional forms of treatment. This study evaluated whether the users of an ED app cluster in clinically meaningful groups. Participants were 1,280 app users (91.3% female; mean age 27) who reported not being in a weekly treatment for their ED. A hierarchical cluster analysis distinguished five groups of participants, all approximating DSM-5 ED categories...
February 16, 2018: Eating Disorders
https://www.readbyqxmd.com/read/29451026/the-tim-system-developing-a-novel-telehealth-service-to-improve-access-to-specialist-care-in-motor-neurone-disease-using-user-centered-design
#10
Esther V Hobson, Wendy O Baird, Rebecca Partridge, Cindy L Cooper, Susan Mawson, Ann Quinn, Pamela J Shaw, Theresa Walsh, Daniel Wolstenholme, Christopher J Mcdermott
OBJECTIVES: Attendance at a specialist multidisciplinary motor neurone disease (MND) clinic is associated with improved survival and may also improve quality of life and reduce hospital admissions. However, patients struggle to travel to clinic and may experience difficulties between clinic visits that may not be addressed in a timely manner. We wanted to explore how we could improve access to specialist MND care. METHODS: We adopted an iterative, user-centered co-design approach, collaborating with those with experience of providing and receiving MND care including patients, carers, clinicians, and technology developers...
February 16, 2018: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/29450927/histological-and-immunohistochemical-evaluation-of-granulosa-cells-during-different-stages-of-folliculogenesis-in-bovine-ovaries
#11
App Teh, U Z Izzati, K Mori, N Fuke, T Hirai, G Kitahara, R Yamaguchi
Bovine granulosa cells (GC) vary in their morphological aspect during different stages of folliculogenesis. In this study, 10 morphologically normal bovine ovaries were collected to study the structural aspects of different stages of GC using intermediate filament protein antibodies including cytokeratin AE1/AE3 (AE1/AE3), vimentin, nectin-4 and desmin. Hormonal immunolocalization was assessed using the immunomarkers anti-Müllerian hormone (AMH) and inhibin alpha. In addition, tumour markers and proliferation markers using c-erbB-2 oncoprotein and proliferating cell nuclear antigen, respectively, were investigated...
February 15, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29450829/artificial-lipid-membrane-permeability-method-for-predicting-intestinal-drug-transport-probing-the-determining-step-in-the-oral-absorption-of-sulfadiazine-influence-of-the-formation-of-binary-and-ternary-complexes-with-cyclodextrins
#12
Alicia Delrivo, Carolina Aloisio, Marcela R Longhi, Gladys Granero
We propose an in vitro permeability assay by using a modified lipid membrane to predict the in vivo intestinal passive permeability of drugs. Two conditions were tested, one with a gradient pH (pH 5.5 donor/pH 7.4 receptor) and the other with an iso-pH 7.4. The predictability of the method was established by correlating the obtained apparent intestinal permeability coefficients (P app ) and the oral dose fraction absorbed in humans (f a ) of 16 drugs with different absorption properties. The P app values correlated well with the absorption rates under the two conditions, and the method showed high predictability and good reproducibility...
February 15, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29449587/the-mechanisms-of-bushen-yizhi-formula-as-a-therapeutic-agent-against-alzheimer-s-disease
#13
Haobin Cai, Yunxia Luo, Xin Yan, Peng Ding, Yujie Huang, Shuhuan Fang, Rong Zhang, Yunbo Chen, Zhouke Guo, Jiansong Fang, Qi Wang, Jun Xu
Bushen-Yizhi prescription (BSYZ) has been an effective traditional Chinese medicine (TCM) prescription in treating Alzheimer's disease (AD) for hundreds of years. However, the underlying mechanisms have not been fully elucidated yet. In this work, a systems pharmacology approach was developed to reveal the underlying molecular mechanisms of BSYZ in treating AD. First, we obtained 329 candidate compounds of BSYZ by in silico ADME/T filter analysis and 138 AD-related targets were predicted by our in-house WEGA algorithm via mapping predicted targets into AD-related proteins...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29449202/a-web-based-psychoeducational-intervention-for-adolescent-depression-design-and-development-of-moodhwb
#14
Rhys Bevan Jones, Anita Thapar, Frances Rice, Harriet Beeching, Rachel Cichosz, Becky Mars, Daniel J Smith, Sally Merry, Paul Stallard, Ian Jones, Ajay K Thapar, Sharon A Simpson
BACKGROUND: Depression is common in adolescence and leads to distress and impairment in individuals, families and carers. Treatment and prevention guidelines highlight the key role of information and evidence-based psychosocial interventions not only for individuals but also for their families and carers. Engaging young people in prevention and early intervention programs is a challenge, and early treatment and prevention of adolescent depression is a major public health concern. There has been growing interest in psychoeducational interventions to provide accurate information about health issues and to enhance and develop self-management skills...
February 15, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29449201/peer-coaching-through-mhealth-targeting-physical-activity-in-people-with-parkinson-disease-feasibility-study
#15
Cristina Colón-Semenza, Nancy K Latham, Lisa M Quintiliani, Terry D Ellis
BACKGROUND: Long-term engagement in exercise and physical activity mitigates the progression of disability and increases quality of life in people with Parkinson disease (PD). Despite this, the vast majority of individuals with PD are sedentary. There is a critical need for a feasible, safe, acceptable, and effective method to assist those with PD to engage in active lifestyles. Peer coaching through mobile health (mHealth) may be a viable approach. OBJECTIVE: The purpose of this study was to develop a PD-specific peer coach training program and a remote peer-mentored walking program using mHealth technology with the goal of increasing physical activity in persons with PD...
February 15, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29448961/nuclear-receptor-agonist-driven-modification-of-inflammation-and-amyloid-pathology-enhances-and-sustains-cognitive-improvements-in-a-mouse-model-of-alzheimer-s-disease
#16
Brad T Casali, Erin G Reed-Geaghan, Gary E Landreth
BACKGROUND: Alzheimer's disease (AD) is a highly prevalent neurodegenerative disorder characterized by pathological hallmarks of beta-amyloid plaque deposits, tau pathology, inflammation, and cognitive decline. Treatment remains a clinical obstacle due to lack of effective therapeutics. Agonists targeting nuclear receptors, such as bexarotene, reversed cognitive deficits regardless of treatment duration and age in murine models of AD. While bexarotene demonstrated marked efficacy in decreasing plaque levels following short-term treatment, prolonged treatment did not modulate plaque burden...
February 15, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29448922/a-randomised-control-crossover-trial-of-a-theory-based-intervention-to-improve-sun-safe-and-healthy-behaviours-in-construction-workers-study-protocol
#17
Amanda Nioi, Charlotte Wendelboe-Nelson, Sue Cowan, Hilary Cowie, Shahzad Rashid, Peter Ritchie, Mark Cherrie, Terry C Lansdown, John W Cherrie
BACKGROUND: Exposure to sunlight can have both positive and negative health impacts. Excessive exposure to ultra-violet (UV) radiation from the sun can cause skin cancer, however insufficient exposure to sunlight has a detrimental effect on production of Vitamin D. In the construction industry there are onsite proactive behaviours for safety, but sun-safety remains a low priority. There is limited research on understanding the barriers to adopting sun-safe behaviours and the association this may have with Vitamin D production...
February 15, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29448235/the-effects-of-screen-media-content-on-young-children-s-executive-functioning
#18
Brittany Huber, Megan Yeates, Denny Meyer, Lorraine Fleckhammer, Jordy Kaufman
Children's exposure to screen-based media has raised concerns for many reasons. One reason is that viewing particular television content has been shown to negatively affect children's executive functioning. Yet, it is unclear whether interacting with a touchscreen device affects executive functioning in the same way as the television research suggests. In the current study, 96 2- and 3-year-old children completed executive functioning measures of working memory and response inhibition and task switching before and after a brief screen intervention consisting of watching an educational television show, playing an educational app, or watching a cartoon...
February 12, 2018: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29448102/a-universal-mini-vector-and-an-annealing-of-pcr-products-app-based-cloning-strategy-for-convenient-molecular-biological-manipulations
#19
Xia Liu, Tuoping Li, Darren J Hart, Song Gao, Hongling Wang, Herui Gao, Shumin Xu, Yifeng Zhang, Yifei Liu, Yingfeng An
Currently, the most widely used strategies for molecular cloning are sticky-end ligation-based cloning, TA cloning, blunt-end ligation-based cloning and ligase-independent cloning. In this study we have developed a novel mini-vector pANY1 which can simultaneously meet the requirements of all the cloning strategies mentioned above. In addition, the selection of appropriate restriction digestion sites is difficult in some cases because of the presence of internal sites. In this study, an annealing of PCR products (APP)-based sticky-end cloning strategy was introduced to avoid this trouble...
February 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29447600/does-self-help-increase-rates-of-help-seeking-for-student-mental-health-problems-by-minimizing-stigma-as-a-barrier
#20
Michael E Levin, Jennifer Krafft, Crissa Levin
OBJECTIVE: This study examined whether self-help (books, websites, mobile apps) increases help seeking for mental health problems among college students by minimizing stigma as a barrier. PARTICIPANTS AND METHODS: A survey was conducted with 200 college students reporting elevated distress from February to April 2017. RESULTS: Intentions to use self-help were low, but a significant portion of students unwilling to see mental health professionals intended to use self-help...
February 15, 2018: Journal of American College Health: J of ACH
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