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https://www.readbyqxmd.com/read/29029055/prognostic-models-for-9-month-mortality-in-tuberculous-meningitis
#1
Le Thi Phuong Thao, A Dorothee Heemskerk, Ronald B Geskus, Nguyen Thi Hoang Mai, Dang Thi Minh Ha, Tran Thi Hong Chau, Nguyen Hoan Phu, Nguyen Van Vinh Chau, Maxine Caws, Nguyen Huu Lan, Do Dang Anh Thu, Nguyen Thuy Thuong Thuong, Jeremy Day, Jeremy J Farrar, M Estee Torok, Nguyen Duc Bang, Guy E Thwaites, Marcel Wolbers
Background: Tuberculous meningitis (TBM) is the most severe form of extra-pulmonary tuberculosis. We developed and validated prognostic models for 9-month mortality in HIV-uninfected and HIV-infected adults with TBM. Methods: We included 1699 subjects from four randomized clinical trials and one prospective observational study conducted at two major referral hospitals in Southern Vietnam from 2001-2015. Modelling was based on multivariable Cox proportional hazards regression...
September 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29028877/rinspector-a-cytoscape-app-for-centrality-analyses-and-dynamine-flexibility-prediction
#2
Guillaume Brysbaert, Kevin Lorgouilloux, Wim Vranken, Marc F Lensink
Motivation: Protein function is directly related to amino acid residue composition and the dynamics of these residues. Centrality analyses based on residue interaction networks permit to identify key residues in a protein that are important for its fold or function. Such central residues and their environment constitute suitable targets for mutagenesis experiments. Predicted flexibility and changes in flexibility upon mutation provide valuable additional information for the design of such experiments...
September 22, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29028843/efficiency-of-different-air-filter-types-for-pig-facilities-at-laboratory-scale
#3
Cindy Wenke, Janina Pospiech, Tobias Reutter, Uwe Truyen, Stephanie Speck
Air filtration has been shown to be efficient in reducing pathogen burden in circulating air. We determined at laboratory scale the retention efficiency of different air filter types either composed of a prefilter (EU class G4) and a secondary fiberglass filter (EU class F9) or consisting of a filter mat (EU class M6 and F8-9). Four filter prototypes were tested for their capability to remove aerosol containing equine arteritis virus (EAV), porcine reproductive and respiratory syndrome virus (PRRSV), bovine enterovirus 1 (BEV), Actinobacillus pleuropneumoniae (APP), and Staphylococcus (S...
2017: PloS One
https://www.readbyqxmd.com/read/29028815/striatal-astrocytes-engulf-dopaminergic-debris-in-parkinson-s-disease-a-study-in-an-animal-model
#4
Ingrid Morales, Alberto Sanchez, Clara Rodriguez-Sabate, Manuel Rodriguez
The role of astrocytes in Parkinson's disease is still not well understood. This work studied the astrocytic response to the dopaminergic denervation. Rats were injected in the lateral ventricles with 6-hydroxydopamine (25μg), inducing a dopaminergic denervation of the striatum not accompanied by non-selective tissue damage. The dopaminergic debris were found within spheroids (free-spheroids) which retained some proteins of dopaminergic neurons (e.g., tyrosine hydroxylase, the dopamine transporter protein, and APP) but not others (e...
2017: PloS One
https://www.readbyqxmd.com/read/29028442/the-use-of-mobile-applications-among-adults-with-type-1-and-type-2-diabetes-results-from-the-second-miles-australia-miles-2-study
#5
Steven Trawley, Shaira Baptista, Jessica L Browne, Frans Pouwer, Jane Speight
BACKGROUND: While the number of diabetes-specific mobile applications (apps) continues to grow, there is a lack of knowledge about their actual use. METHODS: The second MILES (Management and Impact for Long-term Empowerment and Success)-Australia study was a national cross-sectional survey of the psychological, behavioral, and social aspects of diabetes for adults with type 1 diabetes (T1D) and type 2 diabetes (T2D). Associations between diabetes-specific app usage and demographic, clinical, and psychosocial variables were examined...
October 13, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29028262/tsis-an-r-package-to-infer-alternative-splicing-isoform-switches-for-time-series-data
#6
Wenbin Guo, Cristiane P G Calixto, John W S Brown, Runxuan Zhang
Summary: An alternative splicing isoform switch is where a pair of transcript isoforms reverse their relative expression abundances in response to external or internal stimuli. Although computational methods are available to study differential alternative splicing, few tools for detection of isoform switches exist and these are based on pairwise comparisons. Here, we provide the TSIS R package, which is the first tool for detecting significant transcript isoform switches in time-series data...
October 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29027505/impact-of-non-uniform-correlation-structure-on-sample-size-and-power-in-multiple-period-cluster-randomised-trials
#7
J Kasza, K Hemming, R Hooper, Jns Matthews, A B Forbes
Stepped wedge and cluster randomised crossover trials are examples of cluster randomised designs conducted over multiple time periods that are being used with increasing frequency in health research. Recent systematic reviews of both of these designs indicate that the within-cluster correlation is typically taken account of in the analysis of data using a random intercept mixed model, implying a constant correlation between any two individuals in the same cluster no matter how far apart in time they are measured: within-period and between-period intra-cluster correlations are assumed to be identical...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29027435/-preliminary-establishment-of-integration-of-alzheimer-s-disease-and-blood-stasis-syndrome-tree-shrew-model-and-evaluation-of-intervention-of-panax-notoginseng-saponins
#8
Ben Chen, Mei-Chun Qin, Jin-Lan Huang, Deng-Pan Wu, Er-Chu Guo, Zhi-Ping Liu, Zhe-Hao Xu, Xi-Xi Guo, Zhen-Guo Zhong
To establish the integration of Alzheimer's disease(AD) and blood stasis syndrome tree shrew model. Panax notoginseng saponins (PNS) was used to intervene the model to testify the stability of the model. The level of blood stasis of each group in the tree shrew model was evaluated by analyzing five traditional Chinese medicine(TCM) characterizations, four blood coagulation indexes, plasma nitric oxide (NO) level, plasma superoxide dismutase (SOD) level in each group. Hematoxylin and eosin(HE) staining was used to observe the morphological changes of brain hippocampal neuron cell of each group...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29026509/development-and-evaluation-of-a-speech-generating-aac-mobile-app-for-minimally-verbal-children-with-autism-spectrum-disorder-in-mainland-china
#9
Sainan An, Xiaoping Feng, Yue Dai, Hongli Bo, Xiuqing Wang, Mu Li, John Zhuohao Woo, Xingmei Liang, Cheng Guo, Charles Xingchao Liu, Liping Wei
BACKGROUND: Mobile touchscreen devices are currently being used as speech-generating devices (SGDs) and have been shown to promote the communication skills, particularly the requesting skills of children with autism spectrum disorders (ASD) who have limited spoken language. However, no augmentative and alternative communication (AAC) mobile app has been developed and evaluated in the Chinese language in Mainland China. METHODS: We developed an AAC mobile app, which is the first in Mainland China, to our knowledge, named Yuudee (Chinese name (xiaoyudi))...
2017: Molecular Autism
https://www.readbyqxmd.com/read/29026458/safe-opioid-prescription-a-smart-on-fhir-approach-to-clinical-decision-support
#10
Shyamashree Sinha, Mark Jensen, Sarah Mullin, Peter L Elkin
Background Prescription opioid pain medication overuse, misuse and abuse have been a significant contributing factor in the opioid epidemic. The rising death rates from opioid overdose have caused healthcare practitioners and researchers to work on optimizing pain therapy and limiting the prescriptions for pain medications. The state of New York has implemented a prescription drug monitoring program(PDMP), amended public health law to limit the prescription of opioids for acute pain and utilized the resources of the state and county health departments to help in curbing this epidemic...
2017: Online Journal of Public Health Informatics
https://www.readbyqxmd.com/read/29025862/developing-digital-interventions-for-people-living-with-serious-mental-illness-perspectives-from-three-mhealth-studies
#11
REVIEW
Bruno Biagianti, Diego Hidalgo-Mazzei, Nicholas Meyer
The rapidly expanding field of mobile health (mHealth) seeks to harness increasingly affordable and ubiquitous mobile digital technologies including smartphones, tablets, apps and wearable devices to enhance clinical care. Accumulating evidence suggests that mHealth interventions are increasingly being adopted and valued by people living with serious mental illnesses such as schizophrenia and bipolar disorder, as a means of better understanding and managing their condition. We draw on experiences from three geographically and methodologically distinct mHealth studies to provide a pragmatic overview of the key challenges and considerations relating to the process of developing digital interventions for this population...
October 12, 2017: Evidence-based Mental Health
https://www.readbyqxmd.com/read/29025699/adoption-acceptability-and-effectiveness-of-a-mobile-health-app-for-personalized-prostate-cancer-survivorship-care-protocol-for-a-realist-case-study-of-the-ned-app
#12
Quynh Pham, Joseph A Cafazzo, Andrew Feifer
BACKGROUND: By 2030, prostate cancer will be the most commonly diagnosed cancer in North America. To mitigate this impending challenge, comprehensive support mechanisms for disease- and treatment-specific changes in health and well-being must be proactively designed and thoughtfully implemented for streamlined survivorship care. mHealth apps have been lauded as a promising complement to current outpatient treatment and monitoring strategies, but have not yet been widely used to support prostate cancer survivorship needs...
October 12, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29025694/desire-to-be-underweight-exploratory-study-on-a-weight-loss-app-community-and-user-perceptions-of-the-impact-on-disordered-eating-behaviors
#13
Elizabeth Victoria Eikey, Madhu C Reddy, Kayla M Booth, Lynette Kvasny, Johnna L Blair, Victor Li, Erika S Poole
BACKGROUND: Mobile health (mHealth) apps for weight loss (weight loss apps) can be useful diet and exercise tools for individuals in need of losing weight. Most studies view weight loss app users as these types of individuals, but not all users have the same needs. In fact, users with disordered eating behaviors who desire to be underweight are also utilizing weight loss apps; however, few studies give a sense of the prevalence of these users in weight loss app communities and their perceptions of weight loss apps in relation to disordered eating behaviors...
October 12, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29025096/efficacy-of-vibrating-gloves-for-chronic-hand-pain-due-to-osteoarthritis
#14
Robert N Jamison, Anna Mei, Robert R Edwards, Edgar L Ross
Objective: This study investigated the efficacy of vibration technology for women with hand pain due to osteoarthritis (OA) to see if mild compression and small vibrating motors were beneficial with periodic use. Methods: Sixty-nine (N = 69) women with OA hand pain were randomized into two groups, one that used vibrating gloves once a day for 20 minutes (Experimental, N = 34) and one that was monitored for three months without gloves (Control, N = 35)...
September 14, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29024956/lessons-learned-from-piloting-mhealth-informatics-practice-curriculum-into-a-medical-elective
#15
Juanita Fernando, Jennifer Lindley
Introduction: This case study reports the development and delivery of an mHealth elective piloted for first-year undergraduate medical students at Monash University (Australia) and the lessons learned by designers. Results: The students were not as adept at using mHealth devices as the literature had predicted. Expert speakers using mHealth for practice perceptibly engaged students. Force-field analysis was a useful basis for devising end-user evaluative research tools for practice...
August 23, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29024764/-it-s-pretty-hard-to-tell-your-mom-and-dad-that-you-re-on-a-method-exploring-how-an-app-could-promote-adolescents-communication-with-parents-and-partners-to-increase-self-efficacy-in-long-acting-reversible-contraception-use
#16
Emily B Shakibnia, Sarah E Timmons, Melanie A Gold, Samantha Garbers
STUDY OBJECTIVE: Youth-friendly information and support are integral components to promote adolescents' successful use of Long Acting Reversible Contraception (LARC), and smartphone apps offer a promising medium. To inform content development for an app guided by the Health Belief Model, we conducted interviews with adolescent LARC users to assess self-efficacy and experiences with LARC, their communication with parents and partners about LARC, and how apps could support this communication...
October 9, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29023735/shortening-of-an-existing-generic-online-health-related-quality-of-life-instrument-for-dogs
#17
J Reid, L Wiseman-Orr, M Scott
OBJECTIVE: Development, initial validation and reliability testing of a shortened version of a web-based questionnaire instrument to measure generic health-related quality of life in companion dogs, to facilitate smartphone and online use. MATERIALS AND METHODS: The original 46 items were reduced using expert judgment and factor analysis. Items were removed on the basis of item loadings and communalities on factors identified through factor analysis of responses from owners of healthy and unwell dogs, intrafactor item correlations, readability of items in the UK, USA and Australia and ability of individual items to discriminate between healthy and unwell dogs...
October 11, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29023568/demonstrating-the-reliability-of-transdiagnostic-mhealth-routine-outcome-monitoring-in-mental-health-services-using-experience-sampling-technology
#18
Simone J W Verhagen, Juliënne A Berben, Carsten Leue, Anne Marsman, Philippe A E G Delespaul, Jim van Os, Richel Lousberg
BACKGROUND: Routine Outcome Monitoring (ROM) should provide a dynamic, within-treatment forward feedback loop to guide individual treatment decisions across diagnostic categories. It has been suggested that the Experience Sampling Method (ESM), capturing the film of daily life adaptive processes, offers a flexible, personalised and transdiagnostic feedback system for monitoring and adapting treatment strategies. This is the first study that uses an ESM application (the PsyMate™) as a routine mobile-ROM (mROM) tool in an ambulatory mental health setting...
2017: PloS One
https://www.readbyqxmd.com/read/29021256/disruption-of-amyloid-precursor-protein-ubiquitination-selectively-increases-amyloid-beta-a%C3%AE-40-levels-via-presenilin-2-mediated-cleavage
#19
Rebecca L Williamson, Karine Laulagnier, André Miguel Miranda, Marty A Fernandez, Michael S Wolfe, Rémy Sadoul, Gilbert Di Paolo
Amyloid plaques, a neuropathological hallmark 1 of Alzheimer's disease (AD), are largely 2 composed of amyloid beta (Aβ) peptide, derived 3 from cleavage of amyloid precursor protein 4 (APP) by β- and γ-secretases. The endosome is 5 increasingly recognized as an important 6 crossroad for APP and these secretases, with 7 major implications for APP processing and 8 amyloidogenesis. Among various 9 posttranslational modifications affecting APP 10 accumulation, ubiquitination of cytodomain 11 lysines may represent a key signal controlling 12 APP endosomal sorting...
October 11, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29021132/willingness-to-use-mobile-phone-apps-for-hiv-prevention-among-men-who-have-sex-with-men-in-london-web-based-survey
#20
William C Goedel, Jason W Mitchell, Paul Krebs, Dustin T Duncan
BACKGROUND: Many men who have sex with men (MSM) use apps to connect with and meet other MSM. Given that these apps are often used to arrange sexual encounters, it is possible that apps may be suitable venues for messages and initiatives related to HIV prevention such as those to increase HIV testing rates among this population. OBJECTIVE: The purpose of this study was to assess willingness to use a new app for reminders of when to be tested for HIV infection among a sample of MSM in London who use apps to arrange sexual encounters...
October 11, 2017: JMIR MHealth and UHealth
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