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Dee Luo, Penny Wang, Fengxin Lu, Josephine Elias, Jeffrey A Sparks, Yvonne C Lee
BACKGROUND: Mobile health applications (apps) have the potential to help individuals with chronic illnesses learn about, monitor, and manage their condition, but these apps are largely unexamined, with the state and direction of development unclear. OBJECTIVE: We performed a systematic review of publicly available apps, directed toward individuals with rheumatoid arthritis (RA); described their current features; and determined areas of unmet need. METHODS: We searched the iTunes and Google Play App Stores for the term "arthritis" and reviewed the descriptions of these apps for specific mentions of RA...
June 21, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Hong-Lei Gao, Ai-Hua Zhang, Jing-Bo Yu, Hui Sun, Ling Kong, Xiang-Qian Wang, Guang-Li Yan, Liang Liu, Xi-Jun Wang
Alzheimer's disease (AD) is still a major problem nowadays. Under the circumstance of many chemical drugs have poor effects on AD, traditional Chinese medicine has become a hot spot for us due to its multi-target and multi-path advantages. To explore the potential therapeutic targets of Kaixinsan (KXS) protects against AD in APP/PS1 transgenic mice model. All mice were divided into three groups: control group, model group and KXS group. Orally given KXS from two month old, and the control and model groups were given the same dose of distilled water...
June 18, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Kai-Jung Chen, Tsu-Ming Yeh, Fan-Yun Pai, Der-Fa Chen
People are paying greater attention to health. To maintain a good health status and obtain food fast, customers may go to healthy fast-food chain restaurants such as Subway more often than before in China and Taiwan. Healthy fast-food chain restaurants come with a healthy spin, seeking to differentiate themselves from other fast-food restaurants. This paper combined the refined Kano model and the quality function deployment (QFD) method. The refined Kano model was used to understand how customers perceive service attributes developed based on DINESERV measurements...
June 22, 2018: International Journal of Environmental Research and Public Health
Seungeun Lee, Kumju Youn, GyuTae Lim, Jinhyuk Lee, Mira Jun
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease, distinctively characterized by senile plaques, neurofibrillary tangles, and synaptic loss, finally resulting in neuronal death. β-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) and cholinesterases have been identified as therapeutic targets for AD, and the discovery of their inhibitors is of critical importance for developing preventive strategies for AD. To discover natural multi-target compounds possessing BACE1, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) inhibitory properties, major citrus flavanones including hesperetin, naringenin, and hesperidin were evaluated...
June 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Matthew A J Apps, Ryan McKay, Ruben T Azevedo, Harvey Whitehouse, Manos Tsakiris
OBJECTIVE: People are highly attuned to fairness, with people willingly suffering personal costs to prevent others benefitting from unfair acts. Are fairness judgments influenced by group alignments? A new theory posits that we favor ingroups and denigrate members of rival outgroups when our personal identity is fused to a group. Although the mPFC has been separately implicated in group membership and fairness processing, it is unclear whether group alignments affect medial prefrontal cortex (mPFC) activity in response to fairness...
June 22, 2018: Brain and Behavior
Richard Apps, Richard Hawkes, Sho Aoki, Fredrik Bengtsson, Amanda M Brown, Gang Chen, Timothy J Ebner, Philippe Isope, Henrik Jörntell, Elizabeth P Lackey, Charlotte Lawrenson, Bridget Lumb, Martijn Schonewille, Roy V Sillitoe, Ludovic Spaeth, Izumi Sugihara, Antoine Valera, Jan Voogd, Douglas R Wylie, Tom J H Ruigrok
In the original version of this paper, the Title should have been written with "A Consensus paper" to read "Cerebellar Modules and Their Role as Operational Cerebellar Processing Units: A Consensus paper".
June 21, 2018: Cerebellum
Nuno Ribeiro, Luís Moreira, Ana Margarida Pisco Almeida, Filipe Santos-Silva
Cancer prevention should start as early as possible. Young adults would benefit largely from the use of a smartphone app aiming at promoting cancer prevention behaviours. The aims of the study described in this paper are to (1) examine the user participation and engagement with a cancer prevention app in real-life settings and (2) assess changes in the users' cancer prevention behaviours. A cancer prevention smartphone app called Happy was developed and released to the general population. Data from registered app users' (N = 3326) demographics and baseline cancer prevention behaviours was analysed...
June 22, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
Eloise Ferreira, Monique J Bignoux, Tyrone C Otgaar, Nicolas Tagliatti, Katarina Jovanovic, Boitelo T Letsolo, Stefan F T Weiss
Alzheimer's disease (AD) is a neurodegenerative disease caused by accumulation of amyloid beta (Aβ) plaque and neurofibrillary tangle formation. We have shown in vitro , that knock-down and blockade of the 37 kDa/67 kDa Laminin Receptor (LRP/LR) resulted in reduced Aβ induced cytotoxicity and Aβ accumulation. In order to test the effect of blocking LRP/LR on Aβ formation and AD associated symptoms, AD transgenic mice received the anti-LRP/LR specific antibody, IgG1-iS18 through intranasal administration...
June 5, 2018: Oncotarget
Mary D Adu, Usman H Malabu, Emily J Callander, Aduli Eo Malau-Aduli, Bunmi S Malau-Aduli
BACKGROUND: There is increased research interest in the use of mobile phone apps to support diabetes management. However, there are divergent views on what constitute the minimum standards for inclusion in the development of mobile phone apps. Mobile phone apps require an evidence-based approach to development which will consequently impact on their effectiveness. Therefore, comprehensive information on developmental considerations could help designers and researchers to develop innovative and effective patient-centered self-management mobile phone apps for diabetes patients...
June 21, 2018: JMIR MHealth and UHealth
Francesc Lopez Segui, Carme Pratdepadua Bufill, Nuria Abdon Gimenez, Jordi Martinez Roldan, Francesc Garcia Cuyas
BACKGROUND: In Catalonia, the Fundació TIC Salut Social's mHealth Office created the AppSalut Site to showcase to mobile apps in the field of health and social services. Its primary objective was to encourage the public to look after their health. The catalogue allows primary health care doctors to prescribe certified, connected apps, which guarantees a safe and reliable environment for their use. The generated data can be consulted by health care professionals and included in the patient's clinical history...
June 21, 2018: JMIR MHealth and UHealth
Frank W J M Smeenk, Laurien A Schrijver, Hennie C J van Bavel, Eric F J van de Laar
In 2014, a group of physicians of the Catharina Hospital in Eindhoven (The Netherlands) started a project called "Talking about end-of-life care in a timely manner". Just like others in the country, the Eindhoven group noticed that regularly, very frail elderly people were admitted to hospital in acute situations without there ever having been conversations about their wishes concerning treatment options at the end of life. The project aimed to prevent unnecessary admissions and treatments for these frail patients by stimulating physicians, patients and informal caregivers to start conversations about end-of-life care together at an earlier stage...
December 2017: Breathe
Jing Chen, Huangyi Ge, Scott Moore, Weining Yang, Ninghui Li, Robert W Proctor
Communicating cybersecurity risks to mobile-device users is essential. However, existing means of conveying the risks through detailed permission lists are ineffective. Risk indexes that convey overall risk are effective at influencing app-selection decisions, but many users want more information. We examined how users assess the risks associated with downloading applications on the Android platform by comparing various graphical formats of intermediate-level risk displays containing three risk categories: personal privacy; monetary loss; device stability...
June 21, 2018: Journal of Experimental Psychology. Applied
Orna Fennelly, Catherine Blake, Oliver FitzGerald, Roisin Breen, Cliona O'Sullivan, Marie O'Mir, François Desmeules, Caitriona Cunningham
BACKGROUND: Since 2011, advanced practice physiotherapists (APPs) have triaged the care of patients awaiting orthopaedic and rheumatology consultant/specialist doctor appointments in Ireland. APP services have evolved across the major hospitals (n = 16) and, after 5 years, profiling and evaluation of APP services was warranted. The present study profiled the national musculoskeletal APP services, focusing on service, clinician and patient outcome factors. METHODS: An online survey of physiotherapists in the allocated APP posts (n = 25) explored: service organization; clinician profile and experience of the advanced role; and patient wait times and outcome measures...
June 21, 2018: Musculoskeletal Care
Enakshee Jamnadass, Omar Aboumarzouk, Panagiotis Kallidonis, Esteban Emiliani, Thomas Tailly, Stephan Hruby, Francesco Sanguedolce, Gokhan Atis, Mehmet Özsoy, Francesco Greco, Bhaskar K Somani
INTRODUCTION: Kidney stone disease (KSD) affects millions of people worldwide and has an increasing incidence. Social media (SoMe) and search engines are both gaining in usage, whilst also being used by patients to research their conditions and aid in managing them. With this in mind, many authors have expressed the belief that SoMe and search engines can be used by patients and healthcare professionals to improve treatment compliance, and to help counselling and management of conditions such as KSD...
June 21, 2018: Journal of Endourology
Long Tan, Hai-Qiang Li, Yi-Bo Li, Wei Liu, Wei Pang, Yu-Gang Jiang
OBJECTIVES: To identify the genotype of (APP/PS1) transgenic mice and evaluate the changing of cognitive and behavioral fu nctions, provide an effective animal model for the Alzheimer's disease (AD) research. METHODS: Male APP/PS1 transgenic mice mated with female APP/PS1 transgenic mice, and the genotype of their filial mice was identified by PCR. The APP +/PS1 + mice were assigned into AD model group (AD group, n =8), and the APP/PS1 mice were assigned into control group (CT group, n =8)...
February 8, 2018: Chinese Journal of Applied Physiology
Gennifer T Smith, Linkai Li, Yue Zhu, Audrey K Bowden
We introduce a coupled dipstick and microscopy device for analyzing urine samples. The device is capable of accurately assessing urine dipstick results while simultaneously imaging the microscopic contents within the sample. We introduce a long working distance, cellphone-based microscope in combination with an oblique illumination scheme to accurately visualize and quantify particles within the urine sample. To facilitate accurate quantification, we couple the imaging set-up with a power-free filtration system...
June 21, 2018: Lab on a Chip
Youwei Zhu, Haifeng Jiang, Hang Su, Na Zhong, Runji Li, Xiaotong Li, Tianzhen Chen, Haoye Tan, Jiang Du, Ding Xu, Huan Yan, Dawen Xu, Min Zhao
BACKGROUND: Cognitive rehabilitation therapy has been found to improve cognitive deficits and impulse control problems in methamphetamine use disorder (MUD). However, there is limited research regarding this therapy's feasibility when using mobile-based health technologies in supporting recovery from MUD in China. OBJECTIVE: The main aim of this study was to test whether 4 weeks of a newly designed computerized cognitive addiction therapy (CCAT) app can improve cognitive impairments, eliminate drug-related attention bias, and attenuate risk decision-making behaviors in participants with MUD...
June 20, 2018: JMIR MHealth and UHealth
Sherry Pagoto, Bengisu Tulu, Emmanuel Agu, Molly E Waring, Jessica L Oleski, Danielle E Jake-Schoffman
BACKGROUND: Reviews of weight loss mobile apps have revealed they include very few evidence-based features, relying mostly on self-monitoring. Unfortunately, adherence to self-monitoring is often low, especially among patients with motivational challenges. One behavioral strategy that is leveraged in virtually every visit of behavioral weight loss interventions and is specifically used to deal with adherence and motivational issues is problem solving. Problem solving has been successfully implemented in depression mobile apps, but not yet in weight loss apps...
June 20, 2018: JMIR MHealth and UHealth
Yoshimi Fukuoka, Teri G Lindgren, Yonatan Dov Mintz, Julie Hooper, Anil Aswani
BACKGROUND: Regular physical activity is associated with reduced risk of chronic illnesses. Despite various types of successful physical activity interventions, maintenance of activity over the long term is extremely challenging. OBJECTIVE: The aims of this original paper are to 1) describe physical activity engagement post intervention, 2) identify motivational profiles using natural language processing (NLP) and clustering techniques in a sample of women who completed the physical activity intervention, and 3) compare sociodemographic and clinical data among these identified cluster groups...
June 20, 2018: JMIR MHealth and UHealth
J J Ceron, L Pardo-Marin, M Caldin, T Furlanello, L Solano-Gallego, F Tecles, L Bernal, G Baneth, S Martinez-Subiela
BACKGROUND: Dogs with canine leishmaniosis (CanL) due to Leishmania infantum can show a wide spectrum of clinical and clinicopathological findings at the time of diagnosis. The aim of this paper is to describe the possible application of acute phase proteins (APPs) for the characterization and management of this disease, based on previously published information on the utility of APPs in CanL and the experience of the authors in using APPs as analytes in the profiling of canine diseases...
June 20, 2018: BMC Veterinary Research
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