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https://www.readbyqxmd.com/read/29679667/systemic-delivery-of-bace1-sirna-through-neuron-targeted-nanocomplexes-for-treatment-of-alzheimer-s-disease
#1
Pengzhen Wang, Xiaoyao Zheng, Qian Guo, Peng Yang, Xiaoying Pang, Kang Qian, Wei Lu, Qizhi Zhang, Xinguo Jiang
β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is a key enzyme to cleave the amyloid precursor protein to develop Alzheimer's disease (AD). Reducing BACE1 expression in central neuron through RNA interference technology shows great promise to overcome AD. However, to obtain an efficient and neurons-specific delivery of siRNA against BACE1 through systemic administration remains challenging. Here, we design and prepare siRNA nano-carriers based on PEGylated poly(2-(N,N-dimethylamino) ethyl methacrylate) (PEG-PDMAEMA) modified with both the CGN peptide for blood-brain barrier (BBB) penetration and the Tet1 peptide for neuron-specific binding...
April 18, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29678807/digital-inequalities-in-the-use-of-self-tracking-diet-and-fitness-apps-interview-study-on-the-influence-of-social-economic-and-cultural-factors
#2
Faustine Régnier, Louis Chauvel
BACKGROUND: Digital devices are driving economic and social transformations, but assessing the uses, perceptions, and impact of these new technologies on diet and physical activity remains a major societal challenge. OBJECTIVE: We aimed to determine under which social, economic, and cultural conditions individuals in France were more likely to be actively invested in the use of self-tracking diet and fitness apps for better health behaviors. METHODS: Existing users of 3 diet and fitness self-tracking apps (Weight Watchers, MyFitnessPal, and sport apps) were recruited from 3 regions of France...
April 20, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29678805/mobile-health-to-maintain-continuity-of-patient-centered-care-for-chronic-kidney-disease-content-analysis-of-apps
#3
Ying-Li Lee, Yan-Yan Cui, Ming-Hsiang Tu, Yu-Chi Chen, Polun Chang
BACKGROUND: Chronic kidney disease (CKD) is a global health problem with a high economic burden, which is particularly prevalent in Taiwan. Mobile health apps have been widely used to maintain continuity of patient care for various chronic diseases. To slow the progression of CKD, continuity of care is vital for patients' self-management and cooperation with health care professionals. However, the literature provides a limited understanding of the use of mobile health apps to maintain continuity of patient-centered care for CKD...
April 20, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29678804/feasibility-and-acceptability-of-a-web-based-treatment-with-telephone-support-for-postpartum-women-with-anxiety-randomized-controlled-trial
#4
Miriam T Ashford, Ellinor K Olander, Heather Rowe, Jane Rw Fisher, Susan Ayers
BACKGROUND: Postpartum anxiety can have adverse effects on the mother and child if left untreated. Time constraints and stigma are common barriers to postpartum treatment. Web-based treatments offer potential flexibility and anonymity. What Am I Worried About (WaWa) is a self-guided treatment based on cognitive-behavioral and mindfulness principles for women experiencing postpartum anxiety. WaWa was developed in Australia and consists of 9 modules with optional weekly telephone support...
April 20, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29678802/lessons-from-the-dot-contraceptive-efficacy-study-analysis-of-the-use-of-agile-development-to-improve-recruitment-and-enrollment-for-mhealth-research
#5
Dominick Shattuck, Liya T Haile, Rebecca G Simmons
BACKGROUND: Smartphone apps that provide women with information about their daily fertility status during their menstrual cycles can contribute to the contraceptive method mix. However, if these apps claim to help a user prevent pregnancy, they must undergo similar rigorous research required for other contraceptive methods. Georgetown University's Institute for Reproductive Health is conducting a prospective longitudinal efficacy trial on Dot (Dynamic Optimal Timing), an algorithm-based fertility app designed to help women prevent pregnancy...
April 20, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29678606/ketogenic-diet-high-intensity-interval-training-hiit-and-memory-training-in-the-treatment-of-mild-cognitive-impairment-a-case-study
#6
Kaitlyn Dahlgren, Kelly J Gibas
Alzheimer's disease (AD) deaths have increased by 89% since 2000. This alarming trajectory of neurological disease highlights the failure of current best practice. Deteriorating brain fuel supply is the nemesis of intact neurological health. Cerebral hypo-metabolism associated with AD occurs years before onset. Both the ketogenic diet and calorie restriction (fasting) lead to a compensatory rise in ketones to improve energy deficits in the brain derived from cerebral insulin resistance. Two forms of ketone bodies, β-hydroxybutyrate and acetoacetate, fuel the brain during starvation, fasting and strenuous exercise...
April 11, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29678133/popularity-and-impact-of-using-smart-devices-in-medicine-experiences-in-saudi-arabia
#7
Sameer Al-Ghamdi
BACKGROUND: The present study aimed to investigate smart device medical apps currently preferred by physicians in Saudi Arabia and the perceived impact of the apps on patient care. METHODS: Questionnaires for this cross-sectional study on smart device medical apps were randomly emailed to 384 physicians registered in the Saudi Commission of Health Specialists database. A total of 300 physicians returned completed questionnaires, with a response rate of 78.5%. Physician demographics and their perceptions of medical apps were assessed, including questions on the purpose, impact, and types of medical apps used...
April 20, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29678100/the-presence-of-ehealth-support-for-childhood-obesity-guidance
#8
Shalmali Deshpande, Michael J Rigby, Mitch Blair
A rising global obesity epidemic in children has implications for an increase in other chronic diseases and a negative social impact, which should not be ignored. A useful resource in this context could be eHealth due to its popularity amongst children. Additionally, telephone guidance is also considered a powerful health promotion tool. The aim of this study was to investigate the availability of mobile applications (apps), websites, helplines, and advice lines for child obesity guidance, in European countries...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29678065/making-the-care-comprehensive-geriatric-assessment-as-the-core-of-a-total-mobile-long-term-care-support-system-in-china
#9
Yanyan Cui, Dongwei Gong, Bo Yang, Hua Chen, Ming-Hsiang Tu, Chaonan Zhang, Huan Li, Naiwen Liang, Liping Jiang, Polun Chang
Comprehensive Geriatric Assessments (CGAs) have been recommended to be used for better monitoring the health status of elder residents and providing quality care. This study reported how our nurses perceived the usability of CGA component of a mobile integrated-care long term care support system developed in China. We used the Continuity Assessment Record and Evaluation (CARE), developed in the US, as the core CGA component of our Android-based support system, in which apps were designed for all key stakeholders for delivering quality long term care...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29678042/transparency-and-quality-of-health-apps-the-hon-approach
#10
Mayoni Ranasinghe, Aude Cabrera, Nicolas Postel-Vinay, Célia Boyer
We are well into the 21st century and the Internet has been around long enough that there are adults who have not known a world without this wonderful tool. And just as time has gone since the beginnings of the Internet, so too has it developed, probably above and beyond the wildest dreams of its founders. These developments, though mostly positive, also have their share of the not so positive. One of these challenges is the difficulty in maintaining accuracy and quality of all the information, data gathered, aggregated or automatically generated being displayed on the Internet on Web websites or via mobile application, and this is a concern in the health domain...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29678012/acceptance-of-a-mobile-application-supporting-nurses-workflow-at-patient-bedside-results-from-a-pilot-study
#11
Frederic Ehrler, Pascal Ducloux, Danny T Y Wu, Christian Lovis, Katherine Blondon
Supporting caregivers' workflow with mobile applications (apps) is a growing trend. At the bedside, apps can provide new ways to support the documentation process rather than using a desktop computer in a nursing office. Although these applications show potential, few existing reports have studied the real impact of such solutions. At the University Hospitals of Geneva, we developed BEDside Mobility, a mobile application supporting nurses' daily workflow. In a pilot study, the app was trialed in two wards for a period of one month...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29678010/move-a-mobile-app-designed-for-social-health-relations-in-residential-areas
#12
Anne Marie Kanstrup, Pernille Bertelsen, Heilyn Camacho Nunez, Tanja Svarre, Jan Stage
This paper describes the design of MOVE, a mobile app to support people in forming social relations around exercise in residential areas. MOVE was developed in collaboration with residents and health professionals in a neighbourhood identified as a high-risk health area. The app is targeted to those who are motivated but challenged to do exercise and based on a conceptual model to provide users a social horizon of exercise activities in their residential area. We present the design and first evaluation of MOVE, including usability evaluations in controlled and natural settings...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29678009/from-narratives-to-numbers-data-work-and-patient-generated-health-data-in-consultations
#13
Tomas Lindroth, Anna Sigridur Islind, Gunnar Steineck, Johan Lundin
This article presents preliminary findings on how the introduction of patient-generated health data (PGHD) triggers changes during patient-nurse consultations. This article builds on a two-year case study, examining the work practice at a cancer rehabilitation clinic at a Swedish Hospital using PGHD. The study focuses on how nurses' use data, gathered by patients with a mobile phone app, during consultations. The use of PGHD introduce a change in the translation work, the work of turning rich patient descriptions and transform them into data, during the consultation for documentation and clinical decision-making...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677973/yorwalk-desiging-a-smartphone-exercise-application-for-people-with-intermittent-claudication
#14
Ahmed Shalan, Abubakar Abdulrahman, Ibrahim Habli, Garry Tew, Andrew Thompson
Peripheral Arterial Disease (PAD) is a chronic cardiovascular disease. It is highly prevalent in older adults. Mobile Health (mHealth) and Telehealth technologies are considered two central digital solutions for enabling patient-centred care. There is evidence that physical activity apps can improve health outcomes in adults. The aim of this project is to develop a prototype of smart phone app to target patients with PAD, which we named YORwalK, to promote exercise and track changes in walking ability in this population...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677972/reflection-on-mobile-applications-for-blood-pressure-management-a-systematic-review-on-potential-effects-and-initiatives
#15
Reyhaneh Mohammadi, Movahhedeh Ayatolahi Tafti, Soodabeh Hoveidamanesh, Reza Ghanavati, Omid Pournik
INTRODUCTION: Ischemic heart disease and stroke have been considered as the first global leading cause of death in last decades [1]. Blood pressure (BP) management is one of the easiest ways suggested for preventing and controlling cardiovascular diseases before the patient develops complications and death-following outcomes. Appearance of technology advancements in the health system has motivated researchers and health providers to study its different aspects and applications in order to improve disease prevention and management...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677969/consumer-smartwatches-for-collecting-self-report-and-sensor-data-app-design-and-engagement
#16
Anna L Beukenhorst, Jamie C Sergeant, Max A Little, John McBeth, William G Dixon
Longitudinal data from patients' natural environments would benefit chronic disease care, yet most devices cannot collect sensor data alongside patient-reported outcomes. Here we describe Koalap, a consumer cellular smartwatch application that collects patient-reported outcomes alongside physical activity data from various sensors. Additionally, we show preliminary results indicating high engagement of our 26 participants with knee osteoarthritis. Our future work will show whether data collection with consumer smartwatches is feasible in terms of user engagement, acceptability, data quality and consistency...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677962/the-re-relaunching-of-the-dmp-the-french-shared-medical-record-new-features-to-improve-uptake-and-use
#17
Brigitte Séroussi, Jacques Bouaud
Health care delivery for patients with chronic conditions is complex and confusing. Care is often fragmented, less effective, and sometimes harmful. Given the potential for EHRs and other health IT systems to facilitate information flow between providers, patients, and settings, health IT-based measures are of particular interest for care coordination. Health information exchange (HIE) has the potential to improve the quality of healthcare by enabling providers with better access to patient information from multiple sources at the point of care...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677961/last-mile-towards-efficient-healthcare-delivery-in-switzerland-ehealth-enabled-applications-could-speed-up-the-care-process
#18
Yihan Deng, Thomas Bürkle, Jürgen Holm, Erwin Zetz, Kerstin Denecke
A precise and timely care delivery depends on an efficient triage performed by primary care providers and smooth collaboration with other medical specialities. In recent years telemedicine gained increasing importance for efficient care delivery. It's use, however, has been limited by legal issues, missing digital infrastructures, restricted support from health insurances and the digital divide in the population. A new era towards eHealth and telemedicine starts with the establishment of national eHealth regulations and laws...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677528/low-arsenic-bioaccessibility-by-fixation-in-nanostructured-iron-hydr-oxides-quantitative-identification-of-as-bearing-phases
#19
Virginia S T Ciminelli, Daphne C Antônio, Claudia L Caldeira, Erico T F Freitas, Itamar Daniel Delbem, Marcus M Fernandes, Massimo Gasparon, Jack C Ng
A new analytical protocol was developed to provide quantitative, single-particle identification of arsenic in heterogeneous nanoscale mineral phases in soil samples, with a view to establishing its potential risk to human health. Microscopic techniques enabled quantitative, single-particle identification of As-bearing phases in twenty soil samples collected in a gold mining district with arsenic concentrations in range of 8 to 6354 mg kg-1 . Arsenic is primarily observed in association with iron (hydr) oxides in fine intergrowth with phyllosilicates...
March 29, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29676598/modernising-speech-audiometry-using-a-smartphone-application-to-test-word-recognition
#20
Marianne van Zyl, De Wet Swanepoel, Hermanus C Myburgh
OBJECTIVE: This study aimed to develop and assess a method to measure word recognition abilities using a smartphone application (App) connected to an audiometer. DESIGN: Word lists were recorded in South African English and Afrikaans. Analyses were conducted to determine the effect of hardware used for presentation (computer, compact-disc player, or smartphone) on the frequency content of recordings. An Android App was developed to enable presentation of recorded materials via a smartphone connected to the auxiliary input of the audiometer...
April 20, 2018: International Journal of Audiology
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