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https://www.readbyqxmd.com/read/28430602/fluoxetine-attenuates-the-impairment-of-spatial-learning-ability-and-prevents-neuron-loss-in-middle-aged-appswe-psen1de9-double-transgenic-alzheimer-s-disease-mice
#1
Jing Ma, Yuan Gao, Lin Jiang, Feng-Lei Chao, Wei Huang, Chun-Ni Zhou, Wei Tang, Lei Zhang, Chun-Xia Huang, Yi Zhang, Yan-Min Luo, Qian Xiao, Hua-Rong Yu, Rong Jiang, Yong Tang
Selective serotonin reuptake inhibitors (SSRIs) have been reported to increase cognitive performance in some clinical studies of Alzheimer's disease (AD). However, there is a lack of evidence supporting the efficacy of SSRIs as cognition enhancers in AD, and the role of SSRIs as a treatment for AD remains largely unclear. Here, we characterized the impact of fluoxetine (FLX), a well-known SSRI, on neurons in the dentate gyrus (DG) and in CA1 and CA3 of the hippocampus of middle-aged (16 to 17 months old) APPswe/PSEN1dE9 (APP/PS1) transgenic AD model mice...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430137/parent-partner-co-parent-or-partnership-the-need-for-clarity-as-family-systems-thinking-takes-hold-in-the-quest-to-motivate-behavioural-change
#2
Chris May, Li Kheng Chai, Tracy Burrows
Research is increasingly pointing to the importance of extending the focus of childhood obesity intervention to include fathers, fathering figures, and other members of a child's primary parenting network. Advances in communication technology are now making it possible to achieve this aim, within current resources, using modalities such text messaging, web-based resources and apps that extend intervention to parents not in attendance at face to face interactions. However, published research is often unclear as to which parent/s they targeted or engaged with, whether interventions planned to influence behaviours and capabilities across family systems, and how this can be achieved...
April 21, 2017: Children
https://www.readbyqxmd.com/read/28429612/a-unique-database-for-gathering-data-from-a-mobile-app-and-medical-prescription-software-a-useful-data-source-to-collect-and-analyse-patient-reported-outcomes-of-depression-and-anxiety-symptoms
#3
Yoshinori Watanabe, Yoko Hirano, Yuko Asami, Maki Okada, Kazuya Fujita
A unique database named 'AN-SAPO' was developed by Iwato Corp. and Japan Brain Corp. in collaboration with the psychiatric clinics run by Himorogi Group in Japan. The AN-SAPO database includes patients' depression/anxiety score data from a mobile app named AN-SAPO and medical records from medical prescription software named 'ORCA'. On the mobile app, depression/anxiety severity can be evaluated by answering 20 brief questions and the scores are transferred to the AN-SAPO database together with the patients' medical records on ORCA...
April 21, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28429406/haplodeficiency-of-cathepsin-d-does-not-affect-cerebral-amyloidosis-and-autophagy-in-app-ps1-transgenic-mice
#4
Shaowu Cheng, Willayat Y Wani, David A Hottman, Angela Jeong, Dongfeng Cao, Kyle J LeBlanc, Paul Saftig, Jianhua Zhang, Ling Li
Autophagy and lysosomal function are important for protein homeostasis and their dysfunction have been associated with Alzheimer's disease (AD). Increased immunoreactivities of an important lysosomal protease, cathepsin D (Cat D), are evident in amyloid plaques and neurons in patients with AD. The current study tests the hypothesis that deleting one allele of the cathepsin D gene (Ctsd) impacts cerebral β-amyloidosis in APPsw/PS1dE9 (APP/PS1) double transgenic mice. Despite a significant 38% decrease of Cat D level in APP/PS1/Ctsd+/- compared to APP/PS1/Ctsd+/+ mice, no changes in steady state levels and deposition of Aβ were found in the brain...
April 21, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28428642/-technology-and-prevention-in-the-era-of-mobile-health-applications-for-cancer-screening-programs
#5
Fabrizio Bert, Maria Rosaria Gualano, Salvatore Clemente, Giulia Villa, Roberta Siliquini
The Italian national health system provides screening to detect breast, colorecatal and cervical cancers, however, population adherence is not as high as expected. Smartphones and their applications (apps) could be used as a tool to communicate with the population and to help improve adherence. The aim of this study was to analyze the features and functions of smartphone applications aimed at secondary prevention of oncological diseases. In February 2016, we reviewed online app stores, using specific key-words, to search for available apps for cancer screening...
January 2017: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/28428554/network-assisted-analysis-of-gwas-data-identifies-a-functionally-relevant-gene-module-for-childhood-onset-asthma
#6
Y Liu, M Brossard, C Sarnowski, A Vaysse, M Moffatt, P Margaritte-Jeannin, F Llinares-López, M H Dizier, M Lathrop, W Cookson, E Bouzigon, F Demenais
The number of genetic factors associated with asthma remains limited. To identify new genes with an undetected individual effect but collectively influencing asthma risk, we conducted a network-assisted analysis that integrates outcomes of genome-wide association studies (GWAS) and protein-protein interaction networks. We used two GWAS datasets, each consisting of the results of a meta-analysis of nine childhood-onset asthma GWASs (5,924 and 6,043 subjects, respectively). We developed a novel method to compute gene-level P-values (fastCGP), and proposed a parallel dense-module search and cross-selection strategy to identify an asthma-associated gene module...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28428170/who-uses-mobile-phone-health-apps-and-does-use-matter-a-secondary-data-analytics-approach
#7
Jennifer K Carroll, Anne Moorhead, Raymond Bond, William G LeBlanc, Robert J Petrella, Kevin Fiscella
BACKGROUND: Mobile phone use and the adoption of healthy lifestyle software apps ("health apps") are rapidly proliferating. There is limited information on the users of health apps in terms of their social demographic and health characteristics, intentions to change, and actual health behaviors. OBJECTIVE: The objectives of our study were to (1) to describe the sociodemographic characteristics associated with health app use in a recent US nationally representative sample; (2) to assess the attitudinal and behavioral predictors of the use of health apps for health promotion; and (3) to examine the association between the use of health-related apps and meeting the recommended guidelines for fruit and vegetable intake and physical activity...
April 19, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28428169/assessing-the-medication-adherence-app-marketplace-from-the-health-professional-and-consumer-vantage-points
#8
Lindsey E Dayer, Rebecca Shilling, Madalyn Van Valkenburg, Bradley C Martin, Paul O Gubbins, Kristie Hadden, Seth Heldenbrand
BACKGROUND: Nonadherence produces considerable health consequences and economic burden to patients and payers. One approach to improve medication nonadherence that has gained interest in recent years is the use of smartphone adherence apps. The development of smartphone adherence apps has increased rapidly since 2012; however, literature evaluating the clinical app and effectiveness of smartphone adherence apps to improve medication adherence is generally lacking. OBJECTIVE: The aims of this study were to (1) provide an updated evaluation and comparison of medication adherence apps in the marketplace by assessing the features, functionality, and health literacy (HL) of the highest-ranking adherence apps and (2) indirectly measure the validity of our rating methodology by determining the relationship between our app evaluations and Web-based consumer ratings...
April 19, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28428167/developing-a-patient-centered-mhealth-app-a-tool-for-adolescents-with-type-1-diabetes-and-their-parents
#9
Bree E Holtz, Katharine M Murray, Denise D Hershey, Julie K Dunneback, Shelia R Cotten, Amanda J Holmstrom, Arpita Vyas, Molly K Kaiser, Michael A Wood
BACKGROUND: Type 1 diabetes (T1D) afflicts approximately 154,000 people under 20 years of age. Three-quarters of adolescents are not achieving glycosylated hemoglobin (HbA1c) targets, which leads to negative health outcomes. Mobile health (mHealth), the use of technology in health, has been used successfully to improve health in many chronic conditions, including diabetes. OBJECTIVE: The purpose of this study was to use patient-centered research methods to inform and improve the design and functionality of our T1D app, MyT1DHero, and to provide insight for others who are designing a health app for adolescents and parents...
April 19, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28428158/mobile-application-to-promote-adherence-to-oral-chemotherapy-and-symptom-management-a-protocol-for-design-and-development
#10
Joel Nathan Fishbein, Lauren Ellen Nisotel, James John MacDonald, Nicole Amoyal Pensak, Jamie Michele Jacobs, Clare Flanagan, Kamal Jethwani, Joseph Andrew Greer
BACKGROUND: Oral chemotherapy is increasingly used in place of traditional intravenous chemotherapy to treat patients with cancer. While oral chemotherapy includes benefits such as ease of administration, convenience, and minimization of invasive infusions, patients receive less oversight, support, and symptom monitoring from clinicians. Additionally, adherence is a well-documented challenge for patients with cancer prescribed oral chemotherapy regimens. With the ever-growing presence of smartphones and potential for efficacious behavioral intervention technology, we created a mobile health intervention for medication and symptom management...
April 20, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28428157/texting-and-mobile-phone-app-interventions-for-improving-adherence-to-preventive-behavior-in-adolescents-a-systematic-review
#11
Sherif M Badawy, Lisa M Kuhns
BACKGROUND: Many preventable behaviors contribute to adolescent mortality and morbidity. Non-adherence to preventive measures represents a challenge and has been associated with worse health outcomes in this population. The widespread use of electronic communication technologies by adolescents, particularly the use of text messaging (short message service, SMS) and mobile phones, presents new opportunities to intervene on risk and preventive risk behavior, but little is known about their efficacy...
April 19, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28428156/user-interest-in-digital-health-technologies-to-encourage-physical-activity-results-of-a-survey-in-students-and-staff-of-a-german-university
#12
Annett Salzwedel, Sophie Rabe, Thomas Zahn, Julia Neuwirth, Sarah Eichler, Kathrin Haubold, Anne Wachholz, Rona Reibis, Heinz Völler
BACKGROUND: Although the benefits for health of physical activity (PA) are well documented, the majority of the population is unable to implement present recommendations into daily routine. Mobile health (mHealth) apps could help increase the level of PA. However, this is contingent on the interest of potential users. OBJECTIVE: The aim of this study was the explorative, nuanced determination of the interest in mHealth apps with respect to PA among students and staff of a university...
April 19, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28428155/using-persuasive-technology-to-increase-physical-activity-in-people-with-chronic-obstructive-pulmonary-disease-by-encouraging-regular-walking-a-mixed-methods-study-exploring-opinions-and-preferences
#13
Yvonne Kiera Bartlett, Thomas L Webb, Mark S Hawley
BACKGROUND: People with chronic obstructive pulmonary disease (PwCOPD) often experience breathlessness and fatigue, making physical activity challenging. Although many persuasive technologies (such as mobile phone apps) have been designed to support physical activity among members of the general population, current technologies aimed at PwCOPD are underdeveloped and only use a limited range of persuasive technology design principles. OBJECTIVE: The aim of this study was to explore how acceptable different persuasive technology design principles were considered to be in supporting and encouraging physical activity among PwCOPD...
April 20, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28425938/the-sodium-content-of-processed-foods-in-south-africa-during-the-introduction-of-mandatory-sodium-limits
#14
Sanne A E Peters, Elizabeth Dunford, Lisa J Ware, Teresa Harris, Adele Walker, Mariaan Wicks, Tertia van Zyl, Bianca Swanepoel, Karen E Charlton, Mark Woodward, Jacqui Webster, Bruce Neal
BACKGROUND: In June 2016, the Republic of South Africa introduced legislation for mandatory limits for the upper sodium content permitted in a wide range of processed foods. We assessed the sodium levels of packaged foods in South Africa during the one-year period leading up to the mandatory implementation date of the legislation. METHODS: Data on the nutritional composition of packaged foods was obtained from nutrition information panels on food labels through both in-store surveys and crowdsourcing by users of the HealthyFood Switch mobile phone app between June 2015 and August 2016...
April 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28425870/ipreny-pseaac-identify-c-terminal-cysteine-prenylation-sites-in-proteins-by-incorporating-two-tiers-of-sequence-couplings-into-pseaac
#15
Yan Xu, Zu Wang, Chunhui Li, Kuo-Chen Chou
PURPOSE: Occurring at the cysteine residue in the C-terminal of a protein, prenylation is a special kind of post-translational modification (PTM), which may play a key role for statin in altering immune function. Therefore, knowledge of the prenylation sites in proteins is important for drug development as well as for in-depth understanding the biological process concerned. Given a query protein whose C-terminal contains some cysteine residues, which one can be of prenylation or none of them can be prenylated? METHODS: To address this problem, we have developed a new predictor, called "iPreny-PseAAC", by incorporating two tiers of sequence pair coupling effects into the general form of PseAAC (pseudo amino acid composition)...
April 19, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28424586/app-protein-family-signaling-at-the-synapse-insights-from-intracellular-app-binding-proteins
#16
REVIEW
Suzanne Guénette, Paul Strecker, Stefan Kins
Understanding the molecular mechanisms underlying amyloid precursor protein family (APP/APP-like proteins, APLP) function in the nervous system can be achieved by studying the APP/APLP interactome. In this review article, we focused on intracellular APP interacting proteins that bind the YENPTY internalization motif located in the last 15 amino acids of the C-terminal region. These proteins, which include X11/Munc-18-interacting proteins (Mints) and FE65/FE65Ls, represent APP cytosolic binding partners exhibiting different neuronal functions...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28423815/mobile-medical-apps-and-mhealth-devices-a-framework-to-build-medical-apps-and-mhealth-devices-in-an-ethical-manner-to-promote-safer-use-a-literature-review
#17
Mary Sharp, Declan O'Sullivan
This paper presents a preliminary literature review in the area of ethics in the development of Mobile Medical Apps and mHealth. The review included both direct health apps and also apps marketed under the area of well-being in addition to mHealth devices. The following words and combinations of them were used to carry out the search for publications, mHealth, Apps, Ethics. The search engines used were Google Scholar, and PubMed. The paper is restricted to publications since 2012. The total number of papers found was 1,920 of which 84 were reviewed...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423778/developing-healthcare-data-analytics-apps-with-open-data-science-tools
#18
Bibo Hao, Wen Sun, Yiqin Yu, Guotong Xie
Recent advances in big data analytics provide more flexible, efficient, and open tools for researchers to gain insight from healthcare data. Whilst many tools require researchers to develop programs with programming languages like Python, R and so on, which is not a skill set grasped by many researchers in the healthcare data analytics area. To make data science more approachable, we explored existing tools and developed a practice that can help data scientists convert existing analytics pipelines to user-friendly analytics APPs with rich interactions and features of real-time analysis...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423757/a-medication-reminder-mobile-app-does-it-work-for-different-age-ranges
#19
Mina Fallah, Mobin Yasini
Successful medication adherence particularly in elderly with chronic diseases will improve their self-management. Medication reminder systems could be useful to improve this adherence. This study consists of two phases, designing a mobile medical app based on Android platform and then its evaluation. To develop this application, first, the use case scenarios have been hypothesized in partnership with health professionals and patients used to take medications daily. Unified Modeling Language was used to model the use cases...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423744/design-and-validation-of-a-platform-to-evaluate-mhealth-apps
#20
Daniel Philpott, Aziz Guergachi, Karim Keshavjee
Emerging technologies show great potential in the field of patient care. One such technology is mobile heath applications (mhealth apps), which have exploded in number and variety in recent years, and offer great promise in the ability to collect and monitor patient health data. Despite their apparent success in proliferation and user adoption, these applications struggle to integrate into the primary care system and there is scant information regarding their efficacy to effect patient behavior and consequently health outcomes...
2017: Studies in Health Technology and Informatics
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