María Fernanda Lorenzo-Gómez, Bárbara Padilla-Fernández, Javier Flores-Fraile, Sebastián Valverde-Martínez, Ignacio González-Casado, José-María De Dios Hernández, Alfonso Sánchez-Escudero, Manuel-José Vicente Arroyo, Misericordia Martínez-Huélamo, Filomena Herrera Criado, Emilio Blanco-Tarrío, Magaly Márquez-Sánchez, María-Carmen Flores-Fraile, Paula Saz-Leal, José-Antonio Mirón-Canelo, Herney-Andrés García-Perdomo, María-Begoña García-Cenador
PURPOSE: This study aimed to determine the effectiveness of whole-cell bacterial immunotherapy, i.e. MV140 and autovaccines, in reducing the number ofurinary tract infections (UTIs)in frail elderly patients with recurrent UTI (RUTI). METHOD: A prospective cohort observational study was performed including 200 frail elderly subjects suffering RUTI, both females and males, between 2016 and 2018. The effectiveness of autovaccines and the polybacterial formulation MV140 (Uromune®), consisting ofwhole-cell heat-inactivated Escherichia coli25%, Klebsiella pneumoniae25%, Proteus vulgaris25% andEnterococcus faecalis25% were evaluated...
October 8, 2021: Vaccine