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https://www.readbyqxmd.com/read/28608639/abuse-of-rachel-carson-and-misuse-of-ddt-science-in-the-service-of-environmental-deregulation
#1
REVIEW
Jingxiang Yang, Michael D Ward, Bart Kahr
Fake news?? The contact insecticide DDT has been reappraised as a safe, life-saving compound by special interest groups committed to repealing environmental regulations. It is shown in this essay how some specific toxicological data has been misused by those aiming to disingenuously influence public policy. Graphic: Pestroy, a DDT-laced coating marketed in 1946 by Sherwin-Williams Research Laboratories.
June 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28593735/new-insights-into-the-clinical-signs-of-supraventricular-tachycardia-the-sign-of-lace-tying
#2
Dominique Blommaert, Fabien Dormal, Olivier Deceuninck, Olivier Xhaet, Elisabeth Ballant, Luc De Roy
BACKGROUND: Supraventricular tachycardias (SVT) are a common arrhythmia therefore an accurate diagnosis is of clinical importance. Although an ECG performed during tachycardia greatly aids diagnosis, patient history and predisposing factors also improve diagnostic accuracy. METHODS: This prospective study included 100 consecutive patients undergoing electrophysiological study for SVT with the aim to reassess their clinical characteristics and describe frequent predisposing factors, such as the "sign of lace-tying" that to our knowledge has not previously been reported...
June 8, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28589070/agranulocytosis-sequelae-of-chronic-cocaine-use-case-series-and-literature-review
#3
Roma Srivastava, Maira Rizwan, Muhammad Omer Jamil, Palaniandy Kogulan, Donna Salzman
Agranulocytosis is a rare condition with a reported incidence ranging from one to five cases per million population per year. Most commonly, agranulocytosis is secondary to chemotherapeutic agents, however, other medications have also been associated with it. An immune mediated destruction of circulating granulocytes and/or granulocyte precursors secondary to drug-dependent or drug-induced antibodies is the postulated mechanism. Agranulocytosis has also been reported secondary to recreational drug use...
May 3, 2017: Curēus
https://www.readbyqxmd.com/read/28577812/re-envisioning-a-dnp-program-for-quality-and-sustainability
#4
Marcia Killien, Hilaire Thompson, Gail Kieckhefer, Betty Bekemeier, Yoriko Kozuki, Cynthia K Perry
When the University of Washington, School of Nursing determined that its post-BSN-DNP degree program, with multiple specialty tracks and programs of study, was not sustainable, the curriculum was re-envisioned. The revised program is consistent with the American Association of Colleges of Nursing (AACN) Essentials of Doctoral Education for Advanced Nursing Practice and the national Licensure Accreditation, Certification, and Education (LACE) model. The re-envisioned program was conceptualized as a single degree in which students preparing for any specialty would have the same number of required credits with the majority of courses (DNP core) required for all students...
May 2017: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
https://www.readbyqxmd.com/read/28577410/human-health-implications-risk-assessment-and-remediation-of-as-contaminated-water-a-critical-review
#5
REVIEW
Muhammad Bilal Shakoor, Rab Nawaz, Fida Hussain, Maimoona Raza, Shafaqat Ali, Muhammad Rizwan, Sang-Eun Oh, Sajjad Ahmad
Arsenic (As) is a naturally occurring metalloid and Class-A human carcinogen. Exposure to As via direct intake of As-contaminated water or ingestion of As-contaminated edible crops is considered a life threatening problem around the globe. Arsenic-laced drinking water has affected the lives of over 200 million people in 105 countries worldwide. Limited data are available on various health risk assessment models/frameworks used to predict carcinogenic and non-carcinogenic health effects caused by As-contaminated water...
May 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28576941/reduced-slc6a15-in-nucleus-accumbens-d2-neurons-underlies-stress-susceptibility
#6
Ramesh Chandra, T Chase Francis, Hyungwoo Nam, Lace M Riggs, Michel Engeln, Sarah Rudzinskas, Prasad Konkalmatt, Scott J Russo, Gustavo Turecki, Sergio Iniguez, Mary Kay Lobo
Previous research demonstrates that Slc6a15, a neutral amino acid transporter, is associated with depression susceptibility. However, no study examined Slc6a15 in the ventral striatum (nucleus accumbens, NAc) in depression. Given our previous characterization of Slc6a15 as a striatal dopamine-receptor-2 (D2)-neuron enriched gene, we examined the role of Slc6a15 in NAc D2-neurons in mediating susceptibility to stress in male mice. First, we showed that Slc6a15 mRNA was reduced in NAc of mice susceptible to chronic social defeat stress (CSDS), a paradigm that produces behavioral and molecular adaptations that resemble clinical depression...
June 2, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28572631/understanding-the-mechanisms-of-dormancy-in-an-invasive-alien-sycamore-lace-bug-corythucha-ciliata-through-transcript-and-metabolite-profiling
#7
Feng-Qi Li, Ning-Ning Fu, Cheng Qu, Ran Wang, Yi-Hua Xu, Chen Luo
The sycamore lace bug, Corythucha ciliata, is a pest of sycamore trees. In China, it is found in the most northern border where it has been known to become dormant during harsh winters. But the molecular and metabolic basis for dormancy in this insect is still unknown. In this study, we analyzed the transcript and metabolite profiles of this bug to identify key genes and metabolites that are significantly regulated during dormancy in adult females and males. In total, 149 differentially expressed genes (DEGs) were significantly up-regulated and 337 DEGs were significantly down-regulated in dormant adults (both females and males)...
June 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28557532/an-experimental-model-to-study-the-impact-of-lipid-oxidation-on-contact-lens-deposition-in-vitro
#8
Burkhardt S Schuett, Thomas J Millar
PURPOSE: This study was to establish a controlled in vitro test system to study the effect of lipid oxidation on lipid deposition on contact lenses. METHODS: Fatty acids with varying degree of unsaturation were oxidized using the Fenton reaction. The degree of lipid oxidation and the lipid moieties formed during the oxidation were identified and estimated by various lipid staining techniques following separation with thin-layer chromatography, and by measuring thiobarbituric acid reactive substances or peroxides in solution...
May 30, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28543415/the-anatomy-of-research-scandals
#9
Carl Elliott
For the past two years, I have taught a seminar on medical research scandals. The syllabus looks like a highlight reel of exploitation and abuse: children fed plutonium-laced breakfast cereal, prisoners dosed with the active ingredient in Agent Orange, mental patients given psychedelic drugs and massive electroconvulsive therapy before being sent into curare-induced paralysis and a coma. I designed the seminar to crush the idealism of future physicians by illuminating the dark patterns that research scandals typically follow...
May 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28517237/development-of-an-alginate-hydrogel-to-deliver-aqueous-bait-for-pest-ant-management
#10
Jia-Wei Tay, Mark S Hoddle, Ashok Mulchandani, Dong-Hwan Choe
BACKGROUND: Insecticide sprays used for ant control cause environmental contamination. Liquid bait is a safe and effective alternative, but it requires bait stations to dispense the toxicant. We developed a biodegradable hydrogel to deliver liquid bait obviating the need for bait stations. RESULTS: Alginate hydrogel beads with preferred rigidity and maximum hydration in 25% sucrose solution were engineered by optimizing a crosslinking process. The moisture content of the substrate on which the beads were placed and the relative atmospheric humidity significantly influenced water loss dynamics of the hydrated hydrogel beads...
May 18, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28506507/syndrome-surveillance-of-fentanyl-laced-heroin-outbreaks-utilization-of-ems-medical-examiner-and-poison-center-databases
#11
P Quincy Moore, Joseph Weber, Steven Cina, Steven Aks
OBJECTIVE: Describe surveillance data from three existing surveillance systems during an unexpected fentanyl outbreak in a large metropolitan area. METHODS: We performed a retrospective analysis of three data sets: Chicago Fire Department EMS, Cook County Medical Examiner, and Illinois Poison Center. Each included data from January 1, 2015 through December 31, 2015. EMS data included all EMS responses in Chicago, Illinois, for suspected opioid overdose in which naloxone was administered and EMS personnel documented other criteria indicative of opioid overdose...
May 8, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28500526/intermediate-filaments-supporting-cell-shape-and-growth-in-bacteria
#12
Gabriella H Kelemen
For years intermediate filaments (IF), belonging to the third class of filamentous cytoskeletal proteins alongside microtubules and actin filaments, were thought to be exclusive to metazoan cells. Structurally these eukaryote IFs are very well defined, consisting of globular head and tail domains, which flank the central rod-domain. This central domain is dominated by an α-helical secondary structure predisposed to form the characteristic coiled-coil, parallel homo-dimer. These elementary dimers can further associate, both laterally and longitudinally, generating a variety of filament-networks built from filaments in the range of 10 nm in diameter...
2017: Sub-cellular Biochemistry
https://www.readbyqxmd.com/read/28494796/a-malignant-solitary-fibrous-tumour-arising-from-the-first-lumbar-vertebra-and-mimicking-an-osteosarcoma-a-case-report
#13
Naoki Oike, Hiroyuki Kawashima, Akira Ogose, Tetsuo Hotta, Toru Hirano, Takashi Ariizumi, Tetsuro Yamagishi, Hajime Umezu, Shoichi Inagawa, Naoto Endo
BACKGROUND: A solitary fibrous tumour (SFT) is an unusual neoplasm typically found in soft tissues. Although SFTs can arise in the bones, they very rarely arise in the vertebral arch. Here, we describe a case of a SFT that arose in the vertebral arch of the first lumbar (L1) spinal vertebrae and mimicked osteosarcoma. CASE PRESENTATION: A 49-year-old woman presented with a 2-month history of lower back pain and a lumbar region mass. Magnetic resonance imaging demonstrated a heterogeneously enhanced mass in the L1 vertebral arch...
May 11, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28489750/performance-of-the-lace-index-to-identify-elderly-patients-at-high-risk-for-hospital-readmission-in-singapore
#14
Lian Leng Low, Nan Liu, Marcus Eng Hock Ong, Eileen Yining Ng, Andrew Fu Wah Ho, Julian Thumboo, Kheng Hock Lee
Unplanned readmissions may be avoided by accurate risk prediction and appropriate resources could be allocated to high risk patients. The Length of stay, Acuity of admission, Charlson comorbidity index, Emergency department visits in past six months (LACE) index was developed to predict hospital readmissions in Canada. In this study, we assessed the performance of the LACE index in a Singaporean cohort by identifying elderly patients at high risk of 30-day readmissions. We further investigated the use of additional risk factors in improving readmission prediction performance...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28484324/the-roles-of-impact-and-inertia-in-the-failure-of-a-shoelace-knot
#15
Christopher A Daily-Diamond, Christine E Gregg, Oliver M O'Reilly
The accidental untying of a shoelace while walking often occurs without warning. In this paper, we discuss the series of events that lead to a shoelace knot becoming untied. First, the repeated impact of the shoe on the floor during walking serves to loosen the knot. Then, the whipping motions of the free ends of the laces caused by the leg swing produce slipping of the laces. This leads to eventual runaway untangling of the knot. As demonstrated using slow-motion video footage and a series of experiments, the failure of the knot happens in a matter of seconds, often without warning, and is catastrophic...
April 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28453411/pooled-analysis-of-the-prognostic-and-predictive-effects-of-tp53-comutation-status-combined-with-kras-or-egfr-mutation-in-early-stage-resected-non-small-cell-lung-cancer-in-four-trials-of-adjuvant-chemotherapy
#16
Frances A Shepherd, Benjamin Lacas, Gwénaël Le Teuff, Pierre Hainaut, Pasi A Jänne, Jean-Pierre Pignon, Thierry Le Chevalier, Lesley Seymour, Jean-Yves Douillard, Stephen Graziano, Elizabeth Brambilla, Robert Pirker, Martin Filipits, Robert Kratzke, Jean-Charles Soria, Ming-Sound Tsao
Purpose Our previous work evaluated individual prognostic and predictive roles of TP53, KRAS, and EGFR in non-small-cell lung cancer (NSCLC). In this analysis, we explore the prognostic and predictive roles of TP53/KRAS and TP53/EGFR comutations in randomized trials of adjuvant chemotherapy versus observation. Patients and Methods Mutation analyses (wild-type [WT] and mutant) for TP53, KRAS, and EGFR were determined in blinded fashion in multiple laboratories. Primary and secondary end points of pooled analysis were overall survival and disease-free survival...
June 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28420258/lace-up-for-healthy-feet-the-impact-of-shoe-closure-on-plantar-stress-response
#17
Hadi Rahemi, David G Armstrong, Ana Enriquez, Joshua Owl, Talal K Talal, Bijan Najafi
OBJECTIVE: This study examined the impact of shoe closure on plantar thermal stress response (TSR), which is known to be a surrogate of shear stress and skin perfusion. It is aimed to explore potential impact of shoe closure on increasing risk factors associated with plantar ulcers in people with diabetic peripheral neuropathy (DPN). METHODS: Fifteen eligible subjects were enrolled. The left foot was used as a reference and fitted to a self-adjusted and habitual lace-tightening method by each subject...
April 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28409951/electron-number-based-phase-diagram-of-pr_-1-x-lace_-x-cuo_-4-%C3%AE-and-possible-absence-of-disparity-between-electron-and-hole-doped-cuprate-phase-diagrams
#18
Dongjoon Song, Garam Han, Wonshik Kyung, Jeongjin Seo, Soohyun Cho, Beom Seo Kim, Masashi Arita, Kenya Shimada, Hirofumi Namatame, Masaki Taniguchi, Y Yoshida, H Eisaki, Seung Ryong Park, C Kim
We performed annealing and angle resolved photoemission spectroscopy studies on electron-doped cuprate Pr_{1-x}LaCe_{x}CuO_{4-δ} (PLCCO). It is found that the optimal annealing condition is dependent on the Ce content x. The electron number (n) is estimated from the experimentally obtained Fermi surface volume for x=0.10, 0.15 and 0.18 samples. It clearly shows a significant and annealing dependent deviation from the nominal x. In addition, we observe that the pseudo-gap at hot spots is also closely correlated with n; the pseudogap gradually closes as n increases...
March 31, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28390405/fam-face-sg-a-score-for-risk-stratification-of-frequent-hospital-admitters
#19
Lian Leng Low, Nan Liu, Kheng Hock Lee, Marcus Eng Hock Ong, Sijia Wang, Xuan Jing, Julian Thumboo
BACKGROUND: An accurate risk stratification tool is critical in identifying patients who are at high risk of frequent hospital readmissions. While 30-day hospital readmissions have been widely studied, there is increasing interest in identifying potential high-cost users or frequent hospital admitters. In this study, we aimed to derive and validate a risk stratification tool to predict frequent hospital admitters. METHODS: We conducted a retrospective cohort study using the readily available clinical and administrative data from the electronic health records of a tertiary hospital in Singapore...
April 8, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28389868/remodelling-of-lace-plant-leaves-antioxidants-and-ros-are-key-regulators-of-programmed-cell-death
#20
Adrian N Dauphinee, Jacob I Fletcher, Georgia L Denbigh, Christian R Lacroix, Arunika H L A N Gunawardena
Antioxidants and reactive oxygen species are integral for programmed cell death signaling during perforation formation in the lace plant ( Aponogeton madagascariensis ). The lace plant is an excellent model system for studying developmentally regulated programmed cell death (PCD). During early lace plant leaf development, PCD systematically deletes cells resulting in a perforated leaf morphology that is unique in planta. A distinct feature in young lace plant leaves is an abundance of anthocyanins, which have antioxidant properties...
April 7, 2017: Planta
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