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https://www.readbyqxmd.com/read/28317167/semiparametric-methods-for-estimation-of-a-nonlinear-exposure-outcome-relationship-using-instrumental-variables-with-application-to-mendelian-randomization
#1
James R Staley, Stephen Burgess
Mendelian randomization, the use of genetic variants as instrumental variables (IV), can test for and estimate the causal effect of an exposure on an outcome. Most IV methods assume that the function relating the exposure to the expected value of the outcome (the exposure-outcome relationship) is linear. However, in practice, this assumption may not hold. Indeed, often the primary question of interest is to assess the shape of this relationship. We present two novel IV methods for investigating the shape of the exposure-outcome relationship: a fractional polynomial method and a piecewise linear method...
March 20, 2017: Genetic Epidemiology
https://www.readbyqxmd.com/read/28303812/global-eradication-of-measles-are-we-poised
#2
REVIEW
Raghavendra D Kulkarni, G S Ajantha, Aithal R Kiran, K R Pravinchandra
Measles, a highly infectious viral disease is the next target for eradication following poliovirus. Decades of experience with highly effective vaccination has invigorated us to take on this virus. The task is not only Titanic but is laced with intricate issues. Recently, an outbreak of fever with rash occurred on a tertiary care teaching hospital campus and was confirmed serologically as measles outbreak by IgMELISA. Therefore, we searched the literature related to outbreaks, transmission of the measles virus, age groups involved, vaccination strategies, vaccination failure and epidemiological features of the disease and reviewed the possible reasons for such outbreaks and problems in the global eradication of the virus...
January 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28274908/assessing-the-performance-of-a-modified-lace-index-lace-rt-to-predict-unplanned-readmission-after-discharge-in-a-community-teaching-hospital
#3
Christo El Morr, Liane Ginsburg, Seungree Nam, Susan Woollard
BACKGROUND: The LACE index was designed to predict early death or unplanned readmission after discharge from hospital to the community. However, implementing the LACE tool in real time in a teaching hospital required practical unavoidable modifications. OBJECTIVE: The purpose of this study was to validate the implementation of a modified LACE index (LACE-rt) and test its ability to predict readmission risk using data in a hospital setting. METHODS: Data from the Canadian Institute for Health Information's Discharge Abstract Database (DAD), the National Ambulatory Care Reporting System (NACRS), and the hospital electronic medical record for one large community hospital in Toronto, Canada, were used in this study...
March 8, 2017: Interactive Journal of Medical Research
https://www.readbyqxmd.com/read/28268113/fentanyl-laced-heroin-and-its-contribution-to-a-spike-in-heroin-overdose-in-miami-dade-county
#4
Alexander Diaz Bode, Mallika Singh, James Andrews, Girish D Kapur, Amado Alejandro Baez
No abstract text is available yet for this article.
February 28, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28257671/nonsurgical-management-of-midsubstance-achilles-tendinopathy
#5
REVIEW
Shane McClinton, Lace Luedke, Derek Clewley
Midsubstance Achilles tendinopathy is one of the most common lower leg conditions. Most patients can recover with nonsurgical treatment that focuses on tendon loading exercises and, when necessary, symptom modulating treatments such as topical, oral, or injected medication, ice, shoe inserts, manual therapy, stretching, taping, or low-level laser. If unresponsive to initial management, a small percentage of patients may consider shockwave or sclerosing treatment and possibly surgery.
April 2017: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/28235886/the-pearl-score-predicts-90-day-readmission-or-death-after-hospitalisation-for-acute-exacerbation-of-copd
#6
C Echevarria, J Steer, K Heslop-Marshall, S C Stenton, P M Hickey, R Hughes, M Wijesinghe, R N Harrison, N Steen, A J Simpson, G J Gibson, S C Bourke
BACKGROUND: One in three patients hospitalised due to acute exacerbation of COPD (AECOPD) is readmitted within 90 days. No tool has been developed specifically in this population to predict readmission or death. Clinicians are unable to identify patients at particular risk, yet resources to prevent readmission are allocated based on clinical judgement. METHODS: In participating hospitals, consecutive admissions of patients with AECOPD were identified by screening wards and reviewing coding records...
February 24, 2017: Thorax
https://www.readbyqxmd.com/read/28220975/thermodynamic-stability-of-heterodimetallic-lnln-complexes-synthesis-and-dft-studies
#7
Guillem Aromi, Joan González-Fabra, Nuno A G Bandeira, Veronica Velasco, Leoní A Barrios, David Aguilà, Simon J Teat, Olivier Roubeau, Carles Bo
The solid state and solution configuration of the heterodimetallic complexes, (Hpy)[CeEr(HL)3(NO3)(py)(H2O)] (1), (Hpy)[PrSm(HL)3(NO3)(py)(H2O)] (2) and (Hpy)2[LaYb(HL)3(NO3)(H2O)](NO3) (3), where H3L is 6-(3-oxo-3-(2-hydroxyphenyl)propionyl)pyridine-2-carboxylic acid, are analysed experimentally and through DFT calculations. Complexes 2 and 3 are described here for the first time, by means of single crystal X-ray diffraction and mass spectrometry. The theoretical study is also extended to the [LaCe], [LaLu] and [CeGd] analogues...
February 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28166873/effect-of-work-boot-type-on-work-footwear-habits-lower-limb-pain-and-perceptions-of-work-boot-fit-and-comfort-in-underground-coal-miners
#8
Jessica A Dobson, Diane L Riddiford-Harland, Alison F Bell, Julie R Steele
Lower limb injuries are highly prevalent in underground coal mining. Wearing gumboots with inadequate ankle support was thought to contribute to these injuries. Despite the uptake of leather lace-up boots, which provide more ankle support, no recent research could be found investigating the effect of this alternative work boot in underground coal mining. Consequently, this study aimed to determine whether boot type (gumboot, leather lace-up boot) influenced work footwear habits, foot problems, lower limb pain, lower back pain, or perceptions of work boot fit and comfort in underground coal miners...
April 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28158759/a-cluster-of-fentanyl-laced-heroin-deaths-in-2015-in-melbourne-australia
#9
Luke N Rodda, Jennifer L Pilgrim, Matthew Di Rago, Kerryn Crump, Dimitri Gerostamoulos, Olaf H Drummer
No abstract text is available yet for this article.
February 3, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28156510/predicting-hospital-readmissions-in-the-oncology-population
#10
Kristine A Donovan, Mary Turney, C Edward Emnett, Amber Lamoreaux, Diane G Portman
177 Background: The 30-day readmission rate is established as an important indicator of quality of care. The LACE index is commonly used in the general medical setting to predict readmission but its ability to predict readmission with sensitivity and specificity in the oncology population has not yet been examined. At our cancer center, palliative care (PC) consultation is associated with an increased risk for readmission but it is not an element in the LACE index. METHODS: We sought to characterize the operating characteristics of the LACE Index using receiver operating characteristics analyses to predict unplanned readmissions to our cancer center over a 6-week period beginning March 2016...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28113666/uncertainty-visualization-by-representative-sampling-from-prediction-ensembles
#11
Le Liu, Alexander Boone, Ian Ruginski, Lace Padilla, Mary Hegarty, Sarah H Creem-Regehr, William B Thompson, Cem Yuksel, Donald H House
Data ensembles are often used to infer statistics to be used for a summary display of an uncertain prediction. In a spatial context, these summary displays have the drawback that when uncertainty is encoded via a spatial spread, display glyph area increases in size with prediction uncertainty. This increase can be easily confounded with an increase in the size, strength or other attribute of the phenomenon being presented. We argue that by directly displaying a carefully chosen subset of a prediction ensemble, so that uncertainty is conveyed implicitly, such misinterpretations can be avoided...
September 8, 2016: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28068563/a-review-fentanyl-and-non-pharmaceutical-fentanyls
#12
REVIEW
Joji Suzuki, Saria El-Haddad
BACKGROUND: Fentanyl and non-pharmaceutical fentanyls (NPFs) have been responsible for numerous outbreaks of overdoses all over the United States since the 1970s. However, there has been a growing concern in recent years that NPFs are contributing to an alarming rise in the number of opioid-related overdoses. METHODS: The authors conducted a narrative review of the published and grey literature on fentanyl and NPFs in PubMed, Google Scholar, and Google using the following search terms: "fentanyl", "non-pharmaceutical fentanyl", "fentanyl analogs", "fentanyl laced heroin" and "fentanyl overdose"...
February 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28045940/applying-the-integrated-practice-unit-concept-to-a-modified-virtual-ward-model-of-care-for-patients-at-highest-risk-of-readmission-a-randomized-controlled-trial
#13
Lian Leng Low, Shu Yun Tan, Matthew Joo Ming Ng, Wei Yi Tay, Lee Beng Ng, Kanchana Balasubramaniam, Rachel Marie Towle, Kheng Hock Lee
BACKGROUND: Emerging evidence from the virtual ward care model showed that multidisciplinary case management are inadequate to reduce readmissions or death for high risk patients. There is consensus that interventions should encompass both pre-hospital discharge and post-discharge transitional care to be effective. Integrated practice units (IPU) had been proposed as an approach of restructuring the organization and work processes of multidisciplinary teams to achieve value in healthcare...
2017: PloS One
https://www.readbyqxmd.com/read/28045179/heck-functionalization-of-an-asymmetric-aza-bodipy-core-synthesis-of-far-red-infrared-probes-for-bioimaging-applications
#14
Stefano Parisotto, Beatrice Lace, Emma Artuso, Chiara Lombardi, Annamaria Deagostino, Roberto Scudu, Claudio Garino, Claudio Medana, Cristina Prandi
As part of our ongoing work on the synthesis of a new class of plant hormones named Strigolactones (SLs) and their analogues, we became interested in tracing bioactive molecules with red emitting BODIPY fluorophores in order to unravel signaling and distribution of SLs in plants. In this paper we report on an unprecedented Heck functionalization of azadipyrromethenes (aza-DIPY) which allows for the introduction of suitable functional groups to convert aza-BODIPY in bioconjugate complexes useful for untangling biological processes...
January 3, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28012114/differential-effects-of-family-structure-on-religion-and-spirituality-of-emerging-adult-males-and-females
#15
Paul J Handal, John W Lace
This study examined measures of religion and spirituality in a sample of male and female emerging adult college students whose parents were either divorced or intact using the Personal Religious Inventory, the Duke University Religion Index, the Daily Spiritual Experiences Scale, the Spiritual Transcendence Scale, and the Spiritual Involvement and Beliefs Scale. Data were collected online, and 66% of participants received extra credit for participating. A main effect of sex was found, as females reported significantly higher scores than men on all but one measure of religion and spirituality, and the dataset was separated by sex...
December 23, 2016: Journal of Religion and Health
https://www.readbyqxmd.com/read/27987510/-comparison-of-two-shaping-methods-for-double-lumen-endotracheal-tube-intubation-by-shikani-optical-stylet-laryngoscope
#16
T Xu, M Li, M Xu, X Y Guo
OBJECTIVE: To compare the efficacy and safety of two different shaping methods for double-lumen endotracheal tube (DLT).DLT was shaped with the rod of a Shikani optical stylet (SOS) with the tracheal orifice aligned with the convex aspect of the distal curvature or the concave aspect of the distal curvature. METHODS: Patients scheduled for elective thoracic surgery and required intubation with a left-sided DLT were enrolled in this study. They were randomized into two groups...
December 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27981196/social-defeat-stress-induces-depression-like-behavior-and-alters-spine-morphology-in-the-hippocampus-of-adolescent-male-c57bl-6-mice
#17
Sergio D Iñiguez, Antonio Aubry, Lace M Riggs, Jason B Alipio, Roseanna M Zanca, Francisco J Flores-Ramirez, Mirella A Hernandez, Steven J Nieto, David Musheyev, Peter A Serrano
Social stress, including bullying during adolescence, is a risk factor for common psychopathologies such as depression. To investigate the neural mechanisms associated with juvenile social stress-induced mood-related endophenotypes, we examined the behavioral, morphological, and biochemical effects of the social defeat stress model of depression on hippocampal dendritic spines within the CA1 stratum radiatum. Adolescent (postnatal day 35) male C57BL/6 mice were subjected to defeat episodes for 10 consecutive days...
December 2016: Neurobiology of Stress
https://www.readbyqxmd.com/read/27936053/predicting-30-day-readmissions-in-an-asian-population-building-a-predictive-model-by-incorporating-markers-of-hospitalization-severity
#18
Lian Leng Low, Nan Liu, Sijia Wang, Julian Thumboo, Marcus Eng Hock Ong, Kheng Hock Lee
BACKGROUND: To reduce readmissions, it may be cost-effective to consider risk stratification, with targeting intervention programs to patients at high risk of readmissions. In this study, we aimed to derive and validate a prediction model including several novel markers of hospitalization severity, and compare the model with the LACE index (Length of stay, Acuity of admission, Charlson comorbidity index, Emergency department visits in past 6 months), an established risk stratification tool...
2016: PloS One
https://www.readbyqxmd.com/read/27920910/crystal-structure-of-tibi2
#19
Kei Watanabe, Hisanori Yamane
Black granular single crystals of monotitanium dibismuth, TiBi2, were synthesized by slow cooling of a mixture of Bi and Ti from 693 K. The title compound is isostructural with CuMg2 (ortho-rhom-bic Fddd symmetry). Ti atoms are located in square anti-prisms of Bi atoms. The network of one type of Bi atom spirals along the a-axis direction while honeycomb layers of the other type of Bi atom spreading in the ab plane inter-lace one another.
September 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/27917703/principles-of-the-kenzan-method-for-robotic-cell-spheroid-based-3d-bioprinting
#20
Nicanor I Moldovan, Narutoshi Hibino, Koichi Nakayama
Bioprinting is a technology with the prospect to change the way many diseases are treated, by replacing the damaged tissues with live, de novo created bio-similar constructs. However, after more than a decade of incubation and many proofs-of-concept, the field is still in its infancy. The current stagnation is the consequence of its early success: the first bioprinters, and most of those which followed, were modified versions of the 3D printers used in additive manufacturing, redesigned for layer-by-layer dispersion of biomaterials...
December 4, 2016: Tissue Engineering. Part B, Reviews
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