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https://www.readbyqxmd.com/read/29228836/complete-mtdna-sequencing-reveals-mutations-m-9185t-c-and-m-13513g-a-in-three-patients-with-leigh-syndrome
#1
Dita Pelnena, Birute Burnyte, Eriks Jankevics, Baiba Lace, Evelina Dagyte, Kristina Grigalioniene, Algirdas Utkus, Zita Krumina, Jolanta Rozentale, Irina Adomaitiene, Janis Stavusis, Liana Pliss, Inna Inashkina
The most common mitochondrial disorder in children is Leigh syndrome, which is a progressive and genetically heterogeneous neurodegenerative disorder caused by mutations in nuclear genes or mitochondrial DNA (mtDNA). In the present study, a novel and robust method of complete mtDNA sequencing, which allows amplification of the whole mitochondrial genome, was tested. Complete mtDNA sequencing was performed in a cohort of patients with suspected mitochondrial mutations. Patients from Latvia and Lithuania (n = 92 and n = 57, respectively) referred by clinical geneticists were included...
December 12, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/29224235/long-term-cardiovascular-re-programming-by-short-term-perinatal-exposure-to-nicotine-s-main-metabolite-cotinine
#2
Stefano Bastianini, Viviana Lo Martire, Alessandro Silvani, Giovanna Zoccoli, Chiara Berteotti, Hugo Lagercrantz, Anders Arner, Gary Cohen
AIM: Gather "proof-of-concept" evidence of the adverse developmental potential of cotinine (a seemingly benign biomarker of recent nicotine / tobacco smoke exposure). METHODS: Pregnant C57 mice drank nicotine or cotinine-laced water for 6wks from conception (NPRE = 2% saccharin+100μg nicotine/ml; CPRE = 2% saccharin + 10μg cotinine/ml) or 3wks after birth (CPOST = 2% saccharin + 30μg cotinine/ml). Controls drank 2% saccharin (CTRL). At 17±1weeks (male pups; CTRL n=6; CPOST n=6; CPRE n=8; NPRE n=9) we assessed (i) cardiovascular control during sleep; (ii) arterial reactivity ex vivo; (iii) expression of genes involved in arterial constriction / dilation...
December 9, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29202948/queen-anne-s-lace-gooseneck-loosestrife-untitled-poppy-maidenhair-fern-blushing-deathcap-untitled-trillium-and-untitled-trillium-pear-blossom-salamander-by-victor-schrager
#3
Margaret R Wentz
Recognizing the contribution art has had in the Mayo Clinic environment since the original Mayo Clinic Building was finished in 1914, Mayo Clinic Proceedings features some of the numerous works of art displayed throughout the buildings and grounds on Mayo Clinic campuses as interpreted by the author.
December 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29148921/a-predictive-model-for-readmissions-among-medicare-patients-in-a-california-hospital
#4
Ian Duncan, Nhan Huynh
Predictive models for hospital readmission rates are in high demand because of the Centers for Medicare & Medicaid Services (CMS) Hospital Readmission Reduction Program (HRRP). The LACE index is one of the most popular predictive tools among hospitals in the United States. The LACE index is a simple tool with 4 parameters: Length of stay, Acuity of admission, Comorbidity, and Emergency visits in the previous 6 months. The authors applied logistic regression to develop a predictive model for a medium-sized not-for-profit community hospital in California using patient-level data with more specific patient information (including 13 explanatory variables)...
November 17, 2017: Population Health Management
https://www.readbyqxmd.com/read/29142587/factors-associated-with-the-high-prevalence-of-oesophageal-cancer-in-western-kenya-a-review
#5
REVIEW
Gabriel Kigen, Naftali Busakhala, Zipporah Kamuren, Hillary Rono, Wilfred Kimalat, Evangeline Njiru
Oesophageal carcinoma (OC) is highly prevalent in Western Kenya especially among the members of the Kalenjin community who reside in the Northern and Southern areas of the Rift Valley. Previous authors have suggested potential association of environmental and genetic risk factors with this high prevalence. The environmental factors that have been suggested include contamination of food by mycotoxins and/or pesticides, consumption of traditional alcohol (locally referred to "Busaa" and "Chan'gaa"), use of fermented milk ("Mursik"), poor diet, tobacco use and genetic predisposition...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29140645/likelihood-of-entanglement-when-materials-are-dropped-vertically-onto-a-rotating-pto-knuckle
#6
Charles V Schwab, Isaac J Rempe
Power take-off (PTO) is a common method of transferring power from a tractor to a towed piece of machinery. The PTO is also a well-documented cause of severe and often permanent disabling injuries to farm operators. The physical conditions that cause entanglements are not well established. Several studies have explored the parameters of PTO entanglements as materials have been drawn across a rotating PTO knuckle to test for entanglement probability. The objective of this study was to determine probability of entanglement when materials are dropped vertically onto a PTO knuckle spinning at 540 rpm...
November 20, 2017: Journal of Agricultural Safety and Health
https://www.readbyqxmd.com/read/29135549/a-dopeless-diamond-belied-koca-nola-s-cocaine-laced-content
#7
(no author information available yet)
No abstract text is available yet for this article.
December 2017: Anesthesiology
https://www.readbyqxmd.com/read/29133703/cns-small-vessel-vasculitis-distinct-mri-features-and-histopathological-correlation
#8
Kamble J Harsha, Sujit A Jagtap, Tirur R Kapilamoorthy, Chandrasekharan Kesavadas, Bejoy Thomas, Neelima Radhakrishnan
BACKGROUND: Central nervous system (CNS) vasculitis is an uncommon disease, which is a diagnostic and therapeutic challenge for physicians. Large and medium vessel vasculitis is relatively easy to diagnose by angiogram compared to small vessel vasculitis, where angiograms are often normal; imaging features described till date are sensitive but not specific. PURPOSE: Here, we describe distinct magnetic resonance (MR) imaging features of CNS small vessel vasculitis...
November 2017: Neurology India
https://www.readbyqxmd.com/read/29131013/a-new-baltic-population-specific-human-genetic-marker-in-the-pmca4-gene
#9
Janis Stavusis, Inna Inashkina, Baiba Lace, Dita Pelnena, Svetlana Limborska, Andrey Khrunin, Vaidutis Kucinskas, Astrida Krumina, Linda Piekuse, Branko Zorn, Violeta Fodina, Margus Punab, Juris Erenpreiss
OBJECTIVES: The PMCA gene family consists of 4 genes and at least 21 splice variants; among these, the Ca2+ ATPase 4 (PMCA4) gene encodes a plasma membrane protein abundantly expressed in several tissues, including the kidney, heart, and sperm. Knockout of PMCA4 causes infertility due to immotile sperm in mouse models. We therefore investigated variants in this gene for potential association with infertility in groups of Estonian (n = 191) and Latvian (n = 92) men with reduced sperm motility...
2016: Human Heredity
https://www.readbyqxmd.com/read/29116538/environmentally-benign-nanometric-neem-laced-urea-emulsion-for-controlling-mosquito-population-in-environment
#10
Prabhakar Mishra, Merlyn Keziah Samuel, Ruchishya Reddy, Brij Kishore Tyagi, Amitava Mukherjee, Natarajan Chandrasekaran
The increasing risk of vector-borne diseases and the environmental pollution in the day-to-day life due to the usage of the conventional pesticides makes the role of nanotechnology to come into the action. The current study deals with one of the applications of nanotechnology through the formulation of neem urea nanoemulsion (NUNE). NUNE was formulated using neem oil, Tween 20, and urea using the microfluidization method. Prior to the development of nanoemulsion, the ratio of oil/surfactant/urea was optimized using the response surface modeling method...
November 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29093523/spring-warming-increases-the-abundance-of-an-invasive-specialist-insect-links-to-phenology-and-life-history
#11
Rui-Ting Ju, Lei Gao, Shu-Juan Wei, Bo Li
Under global warming, shifts in phenological synchrony between insects and host plants (i.e., changes in the relative timing of the interaction) may reduce resource availability to specialist insects. Some specialists, however, can flexibly track the shifts in host-plant phenology, allowing them to obtain sufficient resources and therefore to benefit from rising temperatures. Here, we investigated the effects of experimental warming on the life history of an invasive, specialist lace bug (Corythucha ciliata) and on the leaf expansion of its host plant (Platanus × acerifolia) in two spring seasons under field conditions in Shanghai, China...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29059661/-constipation-natural-methods-of-the-treatment-with-regard-to-physiotherapeutic-procedures
#12
Jarosław Pasek, Wojciech Latos, Grzegorz Cieślar, Leszek Jagodziński, Aleksander Sieroń
The constipations belong to the most frequent intestinal dyspepsia ailments in the industrialized populations. Alimentary canal answers for the correct admission and digesting foods, their absorption and dismissing. In case of disorders relating dismissing the names a constipation, discomfort in everyday life constrain ill's to modification style of life and nourishing, as well as the frequent contact with a doctor or the specialist medical care. The etiology of constipations stool is multifactorial, what requires multidirectional therapeutic conduction...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29056467/gold-laced-bio-macromolecules-for-theranostic-application
#13
REVIEW
Pranjali Yadav, Surya Prakash Singh, Aravind Kumar Rengan, Asifkhan Shanavas, Rohit Srivastava
Gold nanostructures are promising entities for various biomedical applications, due to their promising physical and optical properties. They can be tailored in different sizes and shapes to play vital roles for photothermal therapy, Biosensing, In vivo X-ray/CT contrast etc. Many biomacromolecules have been used for chemical reduction of ionic gold into zero-valent metallic nanoparticles of specific shape/size followed by stabilizing them for long term utilization. This review will sum up a range of biomacromolecules including Alginate, Agarose, Starch, Carragenan, Cellulose, Chitin, Chitosan, Collagen, Cyclodextrins, Chondrotin Sulfate, Dextran Sulfate, Fucoidan, Gelatin, Guar Gum and Hyaluronic Acid, whose functionalities have been explored in combination with gold nanoparticles for various biomedical applications...
October 19, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29051918/effects-of-ensemble-and-summary-displays-on-interpretations-of-geospatial-uncertainty-data
#14
Lace M Padilla, Ian T Ruginski, Sarah H Creem-Regehr
Ensemble and summary displays are two widely used methods to represent visual-spatial uncertainty; however, there is disagreement about which is the most effective technique to communicate uncertainty to the general public. Visualization scientists create ensemble displays by plotting multiple data points on the same Cartesian coordinate plane. Despite their use in scientific practice, it is more common in public presentations to use visualizations of summary displays, which scientists create by plotting statistical parameters of the ensemble members...
2017: Cognitive Research: Principles and Implications
https://www.readbyqxmd.com/read/29051872/synovial-hemangioma-of-the-knee-management-and-excellent-outcome-2-years-after-arthroscopic-synovectomy-in-a-25-year-old-male-with-a-20-year-history
#15
Akshdeep Singh Bawa, Rajnish Garg, Kaneeka Bhatnagar, Shekhar Singal
INTRODUCTION: Synovial hemangioma is a rare condition with <200 published case reports in world literature and is frequently misdiagnosed, leading to diagnostic delay of many years. This delay is even more significant if the patient comes from a rural background with a dearth of medical facilities in the area. This case had a lag of nearly 20 years from the time of onset of symptoms and the required management which is the maximum reported for any synovial hemangioma since most of them have been found and treated in adolescents...
May 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29030959/ipsc-derived-vascular-cell-spheroids-as-building-blocks-for-scaffold-free-biofabrication
#16
Leni Moldovan, April Barnard, Chang-Hyun Gil, Yang Lin, Maria B Grant, Mervin C Yoder, Nutan Prasain, Nicanor I Moldovan
Recently a protocol is established to obtain large quantities of human induced pluripotent stem cells (iPSC)-derived endothelial progenitors, called endothelial colony forming cells (ECFC), and of candidate smooth-muscle forming cells (SMFC). Here, the suitability for assembling in spheroids, and in larger 3D cell constructs is tested. iPSC-derived ECFC and SMFC are labeled with tdTomato and eGFP, respectively. Spheroids are formed in ultra-low adhesive wells, and their dynamic proprieties are studied by time-lapse microscopy, or by confocal microscopy...
October 14, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29024216/acrochordons-on-the-neck-a-remarkable-clinical-feature-of-tuberous-sclerosis-showing-different-patterns
#17
C Baykal
Sachs and Lipsker(1) recently published a few patients diagnosed with tuberous sclerosis (TS) presenting with multiple loosely arranged acrochordons (molluscum pendulum) located on the posterior neck showing a lace-like distribution and they proposed the term "molluscum pendulum necklace sign" for these typically located lesions. They detected acrochordons in five cases (17%) in a retrospectively analysed consecutive series of 29 TS patients, of whom four (three adults and one child) remarkably showed this typical pattern...
October 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29021583/polydopamine-laced-biomimetic-material-stimulation-of-bone-marrow-derived-mesenchymal-stem-cells-to-promote-osteogenic-effects
#18
Dong Joon Lee, Yan-Ting Lee, Rui Zou, Renie Daniel, Ching-Chang Ko
A hydroxyapatite-collagen (HC) composite material can mimic composition and ultra-structures of natural bone and provide adequate bioactive material-tissue interactions. Incorporation of dopamine (DA) is one of keys in increasing the mechanical strength of the HC material to approaching that of cortical bone. In this study, the in vitro osteogenic effects of polydopamine-laced hydroxyapatite collagen calcium silicate (HCCS-PDA) were examined by culturing rat mesenchymal stem cells (rMSCs) on HCCS-PDA and HCCS coated plates...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28970815/the-evolutionary-psychology-of-envy-and-jealousy
#19
Vilayanur S Ramachandran, Baland Jalal
The old dogma has always been that the most complex aspects of human emotions are driven by culture; Germans and English are thought to be straight-laced whereas Italians and Indians are effusive. Yet in the last two decades there has been a growing realization that even though culture plays a major role in the final expression of human nature, there must be a basic scaffolding specified by genes. While this is recognized to be true for simple emotions like anger, fear, and joy, the relevance of evolutionary arguments for more complex nuances of emotion have been inadequately explored...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28888327/vicarious-social-defeat-stress-induces-depression-related-outcomes-in-female-mice
#20
Sergio D Iñiguez, Francisco J Flores-Ramirez, Lace M Riggs, Jason B Alipio, Israel Garcia-Carachure, Mirella A Hernandez, David O Sanchez, Mary Kay Lobo, Peter A Serrano, Stephen H Braren, Samuel A Castillo
BACKGROUND: Stress is a prevailing risk factor for mood-related illnesses, wherein women represent the majority of those affected by major depression. Despite the growing literature suggesting that affective disorders can arise after a traumatic event is vicariously experienced, this relationship remains understudied in female subjects at the preclinical level. Thus, the objective of the current investigation was to examine whether exposure to emotional and/or psychological stress (ES) mediates depression-related outcomes in female mice...
July 29, 2017: Biological Psychiatry
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