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Mahdi Rezaei, Mohammad Reza Naghavi, Abdolhadi Hosseinzadeh, Alireza Abasi, Jaber Nasiri
Here, a comprehensive endeavor is made to simultaneously scrutinize spatiotemporal oscillations of three imperative morphinan alkaloids (i.e. thebaine, codeine, and morphine) alongside dynamic transcriptional patterns of TYDC, SalAT, COR, T6ODM, and CODM genes in different tissues of Papaver somniferum (i.e. root, bottom part of stem, upper part of stem, leaf, capsule wall, and capsule content) over five distinguished ontogenic stages (i.e. rosette, bud initiation, pendulous bud, flowering, and lancing). Apart from bottom stem and leaf, the maximum thebaine content occurred in lancing stage, while its minimum content did not follow a systematic rhythm, either among six tissues or five various sampling times...
June 2018: Journal of Biosciences
Poorani Anandakrishnan, Teik Beng Khoo
Cerebral demyelination and optic neuritis are often seen in children with acute disseminated encephalomyelitis following various infections and immunisations. An eight month old girl presented with a left axillary lymph node swelling and an erythematous lace-like rash over her cheeks and trunk. She then developed acute encephalopathy, bilateral nystagmus, right hemiparesis and left facial nerve palsy. Her electroencephalogram showed an encephalopathic process and visual evoked response study were grossly abnormal...
May 30, 2018: BMJ Case Reports
Leticia M Mesa, J Hörler, I Lindt, M F Gutiérrez, L Negro, G Mayora, L Montalto, M Ballent, A Lifschitz
Two anthelmintic macrocyclic lactones-ivermectin and moxidectin-have revolutionized parasite control in cattle. These drugs are only partly metabolized by livestock, and the main route of excretion is via feces. In seasonally inundated floodplains, cattle feces come into direct contact with surface water. Important differences in pharmacokinetics and pharmacodynamics between these drugs may bear on their ecotoxicology in aquatic ecosystems. Moxidectin strongly binds to organic matter and thereby may be consumed in aquatic food webs, but there is a scarcity of data on toxicity to freshwater invertebrates...
May 30, 2018: Archives of Environmental Contamination and Toxicology
Sandra Barrios-de Pedro, Francisco José Poyato-Ariza, José Joaquín Moratalla, Ángela D Buscalioni
Coprolites are some of the most abundant fossils at the Las Hoyas site, a well-known Early Cretaceous Konservat-Lagerstätte located in Cuenca, central Spain. The coprolite association is described, introducing taphonomic features and sedimentological properties. This study is based on a subsample of 433 fossils selected from some 2000 specimens collected. The taphonomic features of the coprolites show that their integrity, absence of desiccation marks, and volume are congruent with faeces produced and deposited in an aquatic ecosystem, which were immediately covered by microbial mats...
2018: PloS One
Fabien J Démares, Christian W W Pirk, Susan W Nicolson, Hannelie Human
For two decades, neonicotinoid insecticides have been extensively used worldwide. Targeting neuronal receptors, they have deleterious effects on the behaviour and physiology of many of many beneficial as well as harmful insects. Bees are exposed to these insecticides in pollen and nectar while providing pollination services to agricultural crops, and neonicotinoids have been shown to impair navigation by bees and to decrease their foraging activity. We have previously reported the effect of dietary thiamethoxam on sucrose responsiveness of young worker bees...
May 15, 2018: Journal of Insect Physiology
Ryan J H West, Laura Briggs, Maria Perona Fjeldstad, Richard R Ribchester, Sean T Sweeney
Sphingolipids are found in abundance at synapses and have been implicated in regulation of synapse structure, function and degeneration. Their precise role in these processes, however, remains obscure. Serine Palmitoyl-transferase (SPT) is the first enzymatic step for synthesis of sphingolipids. Analysis of the Drosophila larval neuromuscular junction revealed mutations in the SPT enzyme subunit, lace/SPTLC2 resulted in deficits in synaptic structure and function. Although neuromuscular junction (NMJ) length is normal in lace mutants, the number of boutons per NMJ is reduced to ∼50% of the wild type number...
May 15, 2018: Journal of Comparative Neurology
Camille Schwab, Alexis Le Moigne, Christine Fernandez, Pierre Durieux, Brigitte Sabatier, Virginie Korb-Savoldelli
AIM OF THE STUDY: A potentially avoidable readmission is an unplanned readmission occurring within 30 days of discharge. As 20% of hospitalised elderly patients are rehospitalised as an unplanned readmission, it is necessary to identify with a clinical score those patients who are at risk of readmission and need discharge interventions as a priority. The main objective of this study was to externally validate and compare the 80+ score with the three other scores predicting the risk of unplanned readmission...
May 14, 2018: Swiss Medical Weekly
Gonzalo N Bidart, Jesús Rodríguez-Díaz, Gaspar Pérez-Martínez, María J Yebra
The lactose operon (lacTEGF) from Lactobacillus casei strain BL23 has been previously studied. The lacT gene codes for a transcriptional antiterminator, lacE and lacF for the lactose-specific phosphoenolpyruvate: phosphotransferase system (PTSLac ) EIICB and EIIA domains, respectively, and lacG for the phospho-β-galactosidase. In this work, we have shown that L. casei is able to metabolize N-acetyllactosamine (LacNAc), a disaccharide present at human milk and intestinal mucosa. The mutant strains BL153 (lacE) and BL155 (lacF) were defective in LacNAc utilization, indicating that the EIICB and EIIA of the PTSLac are involved in the uptake of LacNAc in addition to lactose...
May 8, 2018: Scientific Reports
Katsuyuki Murai, Naomi Kakushima, Takashi Sugino, Masao Yoshida, Noboru Kawata, Masaki Tanaka, Kohei Takizawa, Koji Muramatu, Kimihide Kusafuka, Etsuro Bando, Hiroyuki Ono
Epstein-Barr virus-associated gastric cancer (EBV-GC) accounts for approximately 8% of gastric cancers. However, little is known regarding intramucosal EBV-GC. The present study aimed to evaluate endoscopic and clinicopathological characteristics of intramucosal EBV-GC. Pathological data of 172 patients with 173 intramucosal gastric cancers who received gastrectomy with lymph node dissection were obtained for review. EBV-encoded small RNA in situ hybridization (EBER-ISH) was performed using tissue microarray block...
May 5, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Meina Huang, Hua He, Tatyana Belenkaya, Xinhua Lin
Heparan sulfate proteoglycans (HSPGs) have been shown to regulate various developmental processes. However, the function of heparan sulfate (HS) in the development of mammalian stomach has not been characterized yet. Here we investigate the role of epithelial HS in embryonic stomach by examining glycosyltransferase gene Exostoses (multiple) 1 ( Ext1 )-deficient mice. We show that HS exhibits specific and dynamic expression pattern in mouse embryonic stomach. Depletion of the epithelial HS leads to stomach hypoplasia with phenotypic differences in the gastric mucosa between forestomach and hindstomach...
April 26, 2018: Journal of Cell Science
Fengqi Li, Ningning Fu, Du Li, Hetang Chang, Cheng Qu, Ran Wang, Yihua Xu, Chen Luo
The spread of the exotic insect pest sycamore lace bug Corythucha ciliata (Say) is increasing worldwide. The identification of behaviorally active compounds is crucial for reducing the current distribution of this pest. In this study, we identified and documented the expression profiles of genes encoding chemosensory proteins (CSPs) in the sycamore lace bug to identify CSPs that bind to the alarm pheromone geraniol. One CSP ( CcilCSP2 ) that was highly expressed in nymph antennae was found to bind geraniol with high affinity...
2018: Frontiers in Physiology
Han-Wen Cheng, Jie Wang, Yong-Jun Li, Jing Li, Shan Yan, Shiyao Shan, Lingyan Wang, Zakiya Skeete, Chuan-Jian Zhong
The ability to harness the optical or electrical properties of nanoscale particles depends on their assembly in terms of size and spatial characteristics which remains challenging due to lack of size focusing. Electrons provide a clean and focusing agent to initiate the assembly of nanoclusters or nanoparticles. Here an intriguing route is demonstrated to lace gold nanoclusters and nanoparticles in string assembly through electron-initiated nucleation and aggregative growth of Au(I)-thiolate motifs on a thin film substrate...
May 2018: Small
Roger I Vargas, Jaime C Piñero, Neil W Miller
Foraging behavior of wild female melon fly, Bactrocera (Zeugodacus) cucurbitae Coquillett, a worldwide pest of economically important cucurbit crops, was examined through mark and recapture studies in both wild (Kona: dominated by the invasive weed ivy gourd, Coccinea grandis [L.] Voigt [Cucurbitaceae]), and cultivated (Kapoho: dominated by papaya, Carica papaya L. [Caricaceae] orchards) habitats on Hawaii Island. In particular, the extent to which wild melon flies and color-marked F2 females responded to cucumber odor and Solulys yeast hydrolysate laced with ammonium acetate (1%, wt/vol) according to sexual maturity stage and degree of protein hunger was documented...
May 28, 2018: Journal of Economic Entomology
Ranjetta Poobathy, Rahmad Zakaria, Vikneswaran Murugaiyah, Sreeramanan Subramaniam
Anoectochilus sp. and Ludisia discolor are known as Jewel orchids. Both species are terrestrial wild orchids that grow in shaded areas of forests. The Jewel orchids are renowned for the beauty of their leaves, which are dark-green laced with silvery or golden veins. The orchids are used as a cure in various parts of Asia. Overharvesting and anthropogenic disturbances threaten the existence of the Jewel orchids in the wild, necessitating human intervention in their survival. An understanding of the structure and adaptations of a plant may assist in its survival when propagated outside of its habitat...
2018: PloS One
Beatriz Puisac, Iñigo Marcos-Alcalde, María Hernández-Marcos, Pilar Tobajas Morlana, Alina Levtova, Bernd C Schwahn, Corinne DeLaet, Baiba Lace, Paulino Gómez-Puertas, Juan Pié
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency (mitochondrial HMG-CoA synthase deficiency or mHS deficiency, OMIM #605911) is an inborn error of metabolism that affects ketone body synthesis. Acute episodes include vomiting, lethargy, hepatomegaly, hypoglycemia and dicarboxylic aciduria. The diagnosis is difficult due to the relatively unspecific clinical and biochemical presentation, and fewer than 30 patients have been described. This work describes three new patients with mHS deficiency and two missense mutations c...
March 28, 2018: International Journal of Molecular Sciences
Qi Sun, Briana Aguila, Lyndsey D Earl, Carter W Abney, Lukasz Wojtas, Praveen K Thallapally, Shengqian Ma
The potential consequences of nuclear events and the complexity of nuclear waste management motivate the development of selective solid-phase sorbents to provide enhanced protection. Herein, it is shown that 2D covalent organic frameworks (COFs) with unique structures possess all the traits to be well suited as a platform for the deployment of highly efficient sorbents such that they exhibit remarkable performance, as demonstrated by uranium capture. The chelating groups laced on the open 1D channels exhibit exceptional accessibility, allowing significantly higher utilization efficiency...
May 2018: Advanced Materials
John W Lace, Kristen A Haeberlein, Paul J Handal
This study examined differences between male and female emerging adults on low, moderate, and high levels of religious integration in relation to psychological distress. Participants were recruited from undergraduate courses at a religiously affiliated, Midwestern university and completed the integration scale of the Personal Religious Inventory and the Langner Symptom Survey. Due to significantly higher reports of religious integration in female participants, the sample was separated by sex. A significant, negative correlation between religious integration and psychological distress was found only for females...
March 21, 2018: Journal of Religion and Health
Elena Sanchez, Emma Artuso, Chiara Lombardi, Ivan Visentin, Beatrice Lace, Wajeeha Saeed, Marco L Lolli, Piermichele Kobauri, Zahid Ali, Francesca Spyrakis, Pilar Cubas, Francesca Cardinale, Cristina Prandi
Strigolactones (SLs) are plant hormones with various functions in development, responses to stress, and interactions with (micro)organisms in the rhizosphere, including with seeds of parasitic plants. Their perception for hormonal functions requires an α,β-hydrolase belonging to the D14 clade in higher plants; perception of host-produced SLs by parasitic seeds relies on similar but phylogenetically distinct proteins (D14-like). D14 and D14-like proteins are peculiar receptors, because they cleave SLs before undergoing a conformational change that elicits downstream events...
April 23, 2018: Journal of Experimental Botany
Louis Ehwerhemuepha, Donald Bendig, Caroline Steele, Cyril Rakovski, William Feaster
BACKGROUND: Malnutrition is known to be associated with higher morbidity and a risk factor of readmissions in the adult population. In this study, we explore the effect of malnutrition in pediatrics because it may differ from the adult population. METHODS: Data for all inpatient encounters at a tertiary children's hospital within a 2-year period corresponding to 19 702 visits were obtained. The data included demographics, socioeconomic status, registered dietitian diagnosis of malnutrition, and variables of the LACE readmission model...
April 2018: Hospital Pediatrics
Jeffrey R Sachs, Michael E Zapadka, Allen D Elster
BACKGROUND AND PURPOSE: The aim of the study was to describe the prevalence and characteristics of orbital interstitial fluid seen on magnetic resonance (MR) images of infants and young children. MATERIALS AND METHODS: Fat-suppressed axial T2-weighted MR images of 100 consecutive infants and young children (<6 years) without orbital pathology were retrospectively reviewed by 2 neuroradiologists. The presence, location, and extent of high-signal orbital interstitial fluid were characterized and tabulated as a function of age...
February 27, 2018: Journal of Computer Assisted Tomography
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