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https://www.readbyqxmd.com/read/28710226/evaluating-the-predictive-strength-of-the-lace-index-in-identifying-patients-at-high-risk-of-hospital-readmission-following-an-inpatient-episode-a-retrospective-cohort-study
#1
Sarah Damery, Gill Combes
OBJECTIVE: To assess how well the LACE index and its constituent elements predict 30-day hospital readmission, and to determine whether other combinations of clinical or sociodemographic variables may enhance prognostic capability. DESIGN: Retrospective cohort study with split sample design for model validation. SETTING: One large hospital Trust in the West Midlands. PARTICIPANTS: All alive-discharge adult inpatient episodes between 1 January 2013 and 31 December 2014...
July 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28709684/hairpin-structures-with-conserved-sequence-motifs-determine-the-3-ends-of-non-polyadenylated-invertebrate-iridovirus-transcripts
#2
İkbal Agah İnce, Gorben P Piljman, Just M Vlak, Monique M van Oers
Previously, we observed that the transcripts of Invertebrate iridescent virus 6 (IIV6) are not polyadenylated, in line with the absence of canonical poly(A) motifs (AATAAA) downstream of the open reading frames (ORFs) in the genome. Here, we determined the 3' ends of the transcripts of fifty-four IIV6 virion protein genes in infected Drosophila Schneider 2 (S2) cells. By using ligation-based amplification of cDNA ends (LACE) it was shown that the IIV6 mRNAs often ended with a CAUUA motif. In silico analysis showed that the 3'-untranslated regions of IIV6 genes have the ability to form hairpin structures (22-56 nt in length) and that for about half of all IIV6 genes these 3' sequences contained complementary TAATG and CATTA motifs...
July 11, 2017: Virology
https://www.readbyqxmd.com/read/28708848/predicting-all-cause-risk-of-30-day-hospital-readmission-using-artificial-neural-networks
#3
Mehdi Jamei, Aleksandr Nisnevich, Everett Wetchler, Sylvia Sudat, Eric Liu
Avoidable hospital readmissions not only contribute to the high costs of healthcare in the US, but also have an impact on the quality of care for patients. Large scale adoption of Electronic Health Records (EHR) has created the opportunity to proactively identify patients with high risk of hospital readmission, and apply effective interventions to mitigate that risk. To that end, in the past, numerous machine-learning models have been employed to predict the risk of 30-day hospital readmission. However, the need for an accurate and real-time predictive model, suitable for hospital setting applications still exists...
2017: PloS One
https://www.readbyqxmd.com/read/28699940/association-of-stress-biomarkers-with-30-day-unplanned-readmission-and-death
#4
Carole Aubert, Antoine Folly, Mancinetti Marco, Daniel Hayoz, Jacques Donze
BACKGROUND: The theory that posthospitalization stress might increase the risk of postdischarge complications has never been investigated. OBJECTIVE: To assess whether serum levels of stress biomarkers at discharge are associated with readmission and death after an acute-care hospitalization. DESIGN: We prospectively included 346 patients aged ≥50 years admitted to the department of general internal medicine at a large community hospital between April 8, 2013 and September 23, 2013...
July 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28699480/adulteration-practices-of-psychoactive-illicit-drugs-an-updated-review
#5
Renata Solimini, Maria Concetta Rotolo, Manuela Pellegrini, Adele Minutillo, Roberta Pacifici, Francesco Paolo Busardò, Simona Zaami
BACKGROUND: It is well known that powdery drugs such as cocaine and heroin are frequently adulterated or diluted predominantly to obtain more doses and to increase the drug dealer's profits, but also to enhance, to modify or to oppose drug effects. METHODS: The aim of this report is to provide an overview of the recent scientific literature on medicines as well as on new psychoactive substances, used as cutting agents (i.e. pharmacologically active adulterants) and on the related adverse health effects on consumers, possibly due to the synergistic effect of the adulterants laced with substances of abuse, which represent a matter of great concern because of the frequent fatalities...
July 10, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28692616/development-of-a-falls-registry-a-pilot-study
#6
Gina M Berg, Tara Carlson, Joanne Fairchild, Courtney Edwards, Ryan Sorell
Each year approximately 1 in 4 healthy older adults aged 65+ years and 1 in 2 aged 80+ years living in the community will fall. Fall-related injuries are the leading cause of death and disability and cost the United States approximately $31 billion annually. Currently, no repository of scene data exists that informs prevention programs regarding circumstances that contribute to older adult falls. This was a multicenter (4 sites: Kansas, Maryland, Oregon, and Texas) pilot study consisting of interviews of older (55+ years) patients who had been admitted to a trauma center with fall-related injuries...
July 2017: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/28682665/can-life-begin-on-enceladus-a-perspective-from-hydrothermal-chemistry
#7
David Deamer, Bruce Damer
Enceladus is a target of future missions designed to search for existing life or its precursors. Recent flybys of Enceladus by the Cassini probe have confirmed the existence of a long-lived global ocean laced with organic compounds and biologically available nitrogen. This immediately suggests the possibility that life could have begun and may still exist on Enceladus. Here we will compare the properties of two proposed sites for the origin of life on Earth-hydrothermal vents on the ocean floor and hydrothermal volcanic fields at the surface-and ask whether similar conditions could have fostered the origin of life on Enceladus...
July 6, 2017: Astrobiology
https://www.readbyqxmd.com/read/28674666/who-are-the-important-predators-of-sea-turtle-nests-at-wreck-rock-beach
#8
Juan Lei, David T Booth
Excessive sea turtle nest predation is a problem for conservation management of sea turtle populations. This study assessed predation on nests of the endangered loggerhead sea turtle (Caretta caretta) at Wreck Rock beach adjacent to Deepwater National Park in Southeast Queensland, Australia after a control program for feral foxes was instigated. The presence of predators on the nesting dune was evaluated by tracking plots (2 × 1 m) every 100 m along the dune front. There were 21 (2014-2015) and 41 (2015-2016) plots established along the dune, and these were monitored for predator tracks daily over three consecutive months in both nesting seasons...
2017: PeerJ
https://www.readbyqxmd.com/read/28661204/user-survey-of-3-ankle-braces-in-soccer-volleyball-and-running-which-brace-fits-best
#9
Kasper Janssen, Anjulie Van Den Berg, Willem Van Mechelen, Evert Verhagen
CONTEXT:   Recurrence rates for ankle sprains are high. Therefore, preventive measures such as ankle bracing during sports are recommended. OBJECTIVE:   To systematically evaluate the perceived ease of use, quality, comfort, stability, and hindrance of and the overall satisfaction with 3 contemporary brace types in 3 types of sports. DESIGN:   Randomized comparative user survey. SETTING:   Recreational sports: soccer, volleyball, and running...
June 29, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28655333/deworming-of-stray-dogs-and-wild-canines-with-praziquantel-laced-baits-delivered-by-an-unmanned-aerial-vehicle-in-areas-highly-endemic-for-echinococcosis-in-china
#10
Qing Yu, Ning Xiao, Shi-Jie Yang, Shuai Han
BACKGROUND: Canines, the definitive hosts for the parasites causing alveolar (AE) and cystic echinococcosis (CE), are the main source of this infections playing the key role in the transmission. The ten-year mortality rate of AE is extremely high (94%) if the patients are not given sustained treatment. The aim of this field study is to explore the possibility of delivery of praziquantel-laced baits using unmanned aerial vehicles (UAVs) aimed at deworming wild canines in the endemic areas...
June 27, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28608639/abuse-of-rachel-carson-and-misuse-of-ddt-science-in-the-service-of-environmental-deregulation
#11
REVIEW
Jingxiang Yang, Michael D Ward, Bart Kahr
Fake news?? The contact insecticide DDT has been reappraised as a safe, life-saving compound by special interest groups committed to repealing environmental regulations. It is shown in this essay how some specific toxicological data has been misused by those aiming to disingenuously influence public policy. Graphic: Pestroy, a DDT-laced coating marketed in 1946 by Sherwin-Williams Research Laboratories.
June 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28593735/new-insights-into-the-clinical-signs-of-supraventricular-tachycardia-the-sign-of-lace-tying
#12
Dominique Blommaert, Fabien Dormal, Olivier Deceuninck, Olivier Xhaet, Elisabeth Ballant, Luc De Roy
BACKGROUND: Supraventricular tachycardias (SVT) are a common arrhythmia therefore an accurate diagnosis is of clinical importance. Although an ECG performed during tachycardia greatly aids diagnosis, patient history and predisposing factors also improve diagnostic accuracy. METHODS: This prospective study included 100 consecutive patients undergoing electrophysiological study for SVT with the aim to reassess their clinical characteristics and describe frequent predisposing factors, such as the "sign of lace-tying" that to our knowledge has not previously been reported...
June 8, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28589070/agranulocytosis-sequelae-of-chronic-cocaine-use-case-series-and-literature-review
#13
Roma Srivastava, Maira Rizwan, Muhammad Omer Jamil, Palaniandy Kogulan, Donna Salzman
Agranulocytosis is a rare condition with a reported incidence ranging from one to five cases per million population per year. Most commonly, agranulocytosis is secondary to chemotherapeutic agents, however, other medications have also been associated with it. An immune mediated destruction of circulating granulocytes and/or granulocyte precursors secondary to drug-dependent or drug-induced antibodies is the postulated mechanism. Agranulocytosis has also been reported secondary to recreational drug use...
May 3, 2017: Curēus
https://www.readbyqxmd.com/read/28577812/re-envisioning-a-dnp-program-for-quality-and-sustainability
#14
Marcia Killien, Hilaire Thompson, Gail Kieckhefer, Betty Bekemeier, Yoriko Kozuki, Cynthia K Perry
When the University of Washington, School of Nursing determined that its post-BSN-DNP degree program, with multiple specialty tracks and programs of study, was not sustainable, the curriculum was re-envisioned. The revised program is consistent with the American Association of Colleges of Nursing (AACN) Essentials of Doctoral Education for Advanced Nursing Practice and the national Licensure Accreditation, Certification, and Education (LACE) model. The re-envisioned program was conceptualized as a single degree in which students preparing for any specialty would have the same number of required credits with the majority of courses (DNP core) required for all students...
May 2017: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
https://www.readbyqxmd.com/read/28577410/human-health-implications-risk-assessment-and-remediation-of-as-contaminated-water-a-critical-review
#15
REVIEW
Muhammad Bilal Shakoor, Rab Nawaz, Fida Hussain, Maimoona Raza, Shafaqat Ali, Muhammad Rizwan, Sang-Eun Oh, Sajjad Ahmad
Arsenic (As) is a naturally occurring metalloid and Class-A human carcinogen. Exposure to As via direct intake of As-contaminated water or ingestion of As-contaminated edible crops is considered a life threatening problem around the globe. Arsenic-laced drinking water has affected the lives of over 200 million people in 105 countries worldwide. Limited data are available on various health risk assessment models/frameworks used to predict carcinogenic and non-carcinogenic health effects caused by As-contaminated water...
May 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28576941/reduced-slc6a15-in-nucleus-accumbens-d2-neurons-underlies-stress-susceptibility
#16
Ramesh Chandra, T Chase Francis, Hyungwoo Nam, Lace M Riggs, Michel Engeln, Sarah Rudzinskas, Prasad Konkalmatt, Scott J Russo, Gustavo Turecki, Sergio Iniguez, Mary Kay Lobo
Previous research demonstrates that Slc6a15, a neutral amino acid transporter, is associated with depression susceptibility. However, no study examined Slc6a15 in the ventral striatum (nucleus accumbens, NAc) in depression. Given our previous characterization of Slc6a15 as a striatal dopamine-receptor-2 (D2)-neuron enriched gene, we examined the role of Slc6a15 in NAc D2-neurons in mediating susceptibility to stress in male mice. First, we showed that Slc6a15 mRNA was reduced in NAc of mice susceptible to chronic social defeat stress (CSDS), a paradigm that produces behavioral and molecular adaptations that resemble clinical depression...
June 2, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28572631/understanding-the-mechanisms-of-dormancy-in-an-invasive-alien-sycamore-lace-bug-corythucha-ciliata-through-transcript-and-metabolite-profiling
#17
Feng-Qi Li, Ning-Ning Fu, Cheng Qu, Ran Wang, Yi-Hua Xu, Chen Luo
The sycamore lace bug, Corythucha ciliata, is a pest of sycamore trees. In China, it is found in the most northern border where it has been known to become dormant during harsh winters. But the molecular and metabolic basis for dormancy in this insect is still unknown. In this study, we analyzed the transcript and metabolite profiles of this bug to identify key genes and metabolites that are significantly regulated during dormancy in adult females and males. In total, 149 differentially expressed genes (DEGs) were significantly up-regulated and 337 DEGs were significantly down-regulated in dormant adults (both females and males)...
June 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28557532/an-experimental-model-to-study-the-impact-of-lipid-oxidation-on-contact-lens-deposition-in-vitro
#18
Burkhardt S Schuett, Thomas J Millar
PURPOSE: This study was to establish a controlled in vitro test system to study the effect of lipid oxidation on lipid deposition on contact lenses. METHODS: Fatty acids with varying degree of unsaturation were oxidized using the Fenton reaction. The degree of lipid oxidation and the lipid moieties formed during the oxidation were identified and estimated by various lipid staining techniques following separation with thin-layer chromatography, and by measuring thiobarbituric acid reactive substances or peroxides in solution...
May 30, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28543415/the-anatomy-of-research-scandals
#19
Carl Elliott
For the past two years, I have taught a seminar on medical research scandals. The syllabus looks like a highlight reel of exploitation and abuse: children fed plutonium-laced breakfast cereal, prisoners dosed with the active ingredient in Agent Orange, mental patients given psychedelic drugs and massive electroconvulsive therapy before being sent into curare-induced paralysis and a coma. I designed the seminar to crush the idealism of future physicians by illuminating the dark patterns that research scandals typically follow...
May 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28517237/development-of-an-alginate-hydrogel-to-deliver-aqueous-bait-for-pest-ant-management
#20
Jia-Wei Tay, Mark S Hoddle, Ashok Mulchandani, Dong-Hwan Choe
BACKGROUND: Insecticide sprays used for ant control cause environmental contamination. Liquid bait is a safe and effective alternative, but it requires bait stations to dispense the toxicant. We developed a biodegradable hydrogel to deliver liquid bait obviating the need for bait stations. RESULTS: Alginate hydrogel beads with preferred rigidity and maximum hydration in 25% sucrose solution were engineered by optimizing a crosslinking process. The moisture content of the substrate on which the beads were placed and the relative atmospheric humidity significantly influenced water loss dynamics of the hydrated hydrogel beads...
May 18, 2017: Pest Management Science
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