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Satoshi Abe, Basudev Maity, Takafumi Ueno
Self-assembled proteins have specific functions in biology. With inspiration provided by natural protein systems, several artificial protein assemblies have been constructed via site-specific mutations or metal coordination, which have important applications in catalysis, material and bio-supramolecular chemistry. Similar to natural protein assemblies, protein crystals have been recognized as protein assemblies formed of densely-packed monomeric proteins. Protein crystals can be functionalized with metal ions, metal complexes or nanoparticles via soaking, co-crystallization, creating new metal binding sites by site-specific mutations...
December 12, 2017: Current Opinion in Chemical Biology
Wenwei Zhan, Siruo Yu, Liang Gao, Feng Wang, Xue Fu, Gang Sui, Xiaoping Yang
Nowadays, physical absorption has become a feasible method offering an efficient and green route to remove organic pollutants from the industrial wastewater. Inspired by polydopamine (PDA) chemistry, one dimensional PDA functionalized multi-walled carbon nanotubes (MWCNT-PDA) were creatively introduced into graphene aerogel framework to synthesis a robust graphene/MWCNT-PDA composite aerogel (GCPCA). The whole forming process needed no additional reducing agents, significantly reducing the contamination emissions to the environment...
December 15, 2017: ACS Applied Materials & Interfaces
Paul William Bisso, Michelle Tai, Hari Katepalli, Nicolas Bertrand, Daniel Blankschtein, Robert Langer
Hydrophobic self-assembly pairs diverse chemical precursors and simple formulation processes to access a vast array of functional colloids. Exploration of this design space, however, is stymied by lack of broadly general, high-throughput colloid characterization tools. Here, we show that a narrow structural subset of fluorescent, zwitterionic molecular rotors - dialkylaminostilbazolium sulfonates [DASS] with intermediate-length alkyl tails - fills this major analytical void by quantitatively sensing hydrophobic interfaces in microplate format...
December 15, 2017: Nano Letters
Judith P Klinman, Adam R Offenbacher, Shenshen Hu
The physical basis for enzymatic rate accelerations is a subject of great fundamental interest and of direct relevance to areas that include the de novo design of green catalysts and the pursuit of new drug regimens. Extensive investigations of C-H activating systems have provided considerable insight into the relationship between an enzyme's overall structure and the catalytic chemistry at its active site. This Perspective highlights recent experimental data for two members of distinct, yet iconic C-H activation enzyme classes, lipoxygenases and prokaryotic alcohol dehydrogenases...
December 15, 2017: Journal of the American Chemical Society
Wei Liu, Mani Ulaganathan, Ibrahim Abdelwahab, Xin Luo, Zhongxin Chen, Sherman Jun Rong Tan, Xiaowei Wang, Yanpeng Liu, Dechao Geng, Yang Bao, Jianyi Chen, Kian Ping Loh
Two-dimensional (2-D) polymer has properties that are attractive for energy storage applications because of its combination of heteroatoms, porosities and layered structure, which provides redox chemistry and ion diffusion routes through the 2-D planes and 1-D channels. Here, conjugated aromatic polymers (CAPs) were synthesized in quantitative yield via solid-state polymerization of phenazine-based precursor crystals. By choosing flat molecules (2-TBTBP and 3-TBQP) with different positions of bromine substituents on a phenazine-derived scaffold, C-C cross coupling was induced following thermal debromination...
December 15, 2017: ACS Nano
Anton O Oliynyk, Arthur Mar
Intermetallic compounds are bestowed by diverse compositions, complex structures, and useful properties for many materials applications. How metallic elements react to form these compounds and what structures they adopt remain challenging questions that defy predictability. Traditional approaches offer some rational strategies to prepare specific classes of intermetallics, such as targeting members within a modular homologous series, manipulating building blocks to assemble new structures, and filling interstitial sites to create stuffed variants...
December 15, 2017: Accounts of Chemical Research
James Lara, Mahder Teka, Yury Khudyakov
BACKGROUND: Identification of acute or recent hepatitis C virus (HCV) infections is important for detecting outbreaks and devising timely public health interventions for interruption of transmission. Epidemiological investigations and chemistry-based laboratory tests are 2 main approaches that are available for identification of acute HCV infection. However, owing to complexity, both approaches are not efficient. Here, we describe a new sequence alignment-free method to discriminate between recent (R) and chronic (C) HCV infection using next-generation sequencing (NGS) data derived from the HCV hypervariable region 1 (HVR1)...
December 6, 2017: BMC Genomics
Tappey H Jones, Dylan M Guthrie, Conor T Hogan, Donovan J Robinson, Robert Mesibov, William A Shear, Thomas F Spande, Ralph A Saporito
Millipedes (Diplopoda) are well known for their toxic or repellent defensive secretions. As part of a larger investigation, we describe the chemical constituents of 14 species of Tasmanian millipedes in seven genera. Six species in the genus Gasterogramma were found to produce acyclic ketones, including the pungent unsaturated ketones 1, 2, and 6, and the novel (rel-3R,5S,7S)-3,5,7-trimethyl-2,8-decanedione (7b), for which the stereoconfiguration was established by stereoselective syntheses of pairs of isomers...
December 15, 2017: Journal of Natural Products
Guojia Wan, Feihu Guo, Hui Li, Yuliang Cao, Xinping Ai, Jiangfeng Qian, Yangxing Li, Hanxi Yang
The growth and proliferation of Li dendrites during repeated Li cycling has long been a crucial issue that hinders the development of secondary Li metal batteries. Building a stable and robust solid state electrolyte interphases (SEI) on Li anode surface is regarded as a promising strategy to overcome the dendrites issues. In this work, we report a simple strategy to engineer the interface chemistry of Li metal anode by using tiny amount of dimethyl sulfate (DMS, C2H6SO4) as SEI-formation additive. With the preferential reduction of DMS, a SEI layer composed of Li2S/Li2O forms on the Li surface...
December 15, 2017: ACS Applied Materials & Interfaces
Mariane Le Fur, Enikő Molnár, Maryline Beyler, Ferenc K Kálmán, Olivier Fougère, David Esteban-Gómez, Olivier Rousseaux, Raphaël Tripier, Gyula Tircsó, C Platas-Iglesias
The geometric features of two pyclen-based ligands possessing identical donor atoms but different site organization have a profound impact in their complexation properties toward lanthanide ions. The ligand containing two acetate groups and a picolinate arm arranged in a symmetrical fashion (L1) forms a Gd3+ complex being two orders of magnitude less stable than its dissymmetric analogue GdL2. Besides, GdL1 experiences a much faster dissociation following the acid-catalyzed mechanism than GdL2. On the contrary, GdL1 exhibits a lower exchange rate of the coordinated water molecule compared to GdL2...
December 15, 2017: Chemistry: a European Journal
Minh V Duong, Hieu T Nguyen, Tam V-T Mai, Lam K Huynh
Master equation/Rice-Ramsperger-Kassel-Marcus (ME/RRKM) has shown to be a powerful framework for modeling kinetic and dynamic behaviors of a complex gas-phase chemical system on a complicated multiple-species and multiple-channel potential energy surface (PES) for a wide range of temperatures and pressures. Derived from the ME time-resolved species profiles, the macroscopic or phenomenological rate coefficients are essential for many reaction engineering applications including those in combustion and atmospheric chemistry...
December 15, 2017: Physical Chemistry Chemical Physics: PCCP
Hima Gopinath, Kaliaperumal Karthikeyan
Turmeric (Curcuma longa L.) is an integral part of Asian culture and cuisine. It has been used in traditional medicine since centuries. A myriad of health benefits have been attributed to it. Curcumin, the most biologically active curcuminoid in turmeric, is being investigated in pre-clinical and clinical trials for its role in disease prevention and cure. It has antioxidant, anti-inflammatory, antineoplastic, anti-proliferative and antimicrobial effects. We review the chemistry of this plant, its cultural relevance in Indian skin care, and its uses in dermatology...
December 14, 2017: Indian Journal of Dermatology, Venereology and Leprology
Giovanna Lucia Delogu, Maria Joao Matos
Degenerative diseases are becoming increasingly prevalent with the aging of the human population. The twentieth century witnessed a significant demographic change in the industrialized world that is currently followed by a similar shift of life expectancy to upper age ranges in Asia, Africa, and Middle and South America. A rising tide of chronic age-dependent diseases will soon present serious challenges for these countries. Age-related diseases are commonly seen in older patients. More than 40% of adults 60 and older have a combination of risk factors known as metabolic syndrome, which increases the risk for developing degenerative disorders, and certain cancers...
December 14, 2017: Current Topics in Medicinal Chemistry
Xin-Liang Hu, Chuan Gao, Zhi Xu, Ming-Liang Liu, Lian-Shun Feng, Guang-De Zhang
Malaria still remains one of the leading deadliest diseases throughout the world, leading to around 1 million deaths annually. The emergence and spread of growing resistance to the first-line antimalarials, alarming the serious problem in malaria control and demanding the need for new drugs more potent than earlier with improved absorption, distribution, metabolism, and excretion (ADME) profiles. Coumarins, which exhibited various biological properties, also displayed potential in vitro antiplasmodial and in vivo antimalarial activities...
December 14, 2017: Current Topics in Medicinal Chemistry
Yasuhiro Meguro, Masato Noguchi, Gefei Li, Shin-Ichiro Shoda
S-Glycosyl thiosulfates have been discovered as a new class of synthetic intermediates in sugar chemistry, named "glycosyl Bunte salts" after 19th-century German chemist, Hans Bunte. The synthesis was achieved by direct condensation of unprotected sugars and sodium thiosulfate using a formamidine-type dehydrating agent in water-acetonitrile mixed solvent. The application of glycosyl Bunte salts is demonstrated with transformation reactions into other glycosyl compounds such as a 1-thio sugar, a glycosyl disulfide, a 1,6-anhydro sugar, and an O-glycoside...
December 15, 2017: Organic Letters
Zhongju Ye, Lin Wei, Xuyao Zeng, Rui Weng, Xingbo Shi, Naidong Wang, Langxing Chen, Lehui Xiao
Exploring the diffusion dynamics of viral capsid proteins (VCP) functionalized nanocarrier on living cell membrane could provide plenty of kinetic information for the better understanding of their biological functionality. Gold nanoparticles are excellent core material of nanocarrier because of the good bio-compatibility as well as versatile surface chemistry. However, due to the strong scattering background from subcellular organelles, it is a grand challenge to selectively image individual nanocarrier on living cell membrane...
December 15, 2017: Analytical Chemistry
Yugen Zhang, Xiukai Li, Jogie Ko
Maleic anhydride (MAnh) and its acids are critical intermediates in chemical industry. The synthesis of maleic anhydride from renewable furfural is one of the most sought after processes in the field of sustainable chemistry. We report a plate vanadium phosphorous oxide (VPO) catalyst synthesized by a hydrothermal method with glucose as a green reducing agent for furfural oxidation to MAnh in gas phase. The plate VPOHT catalyst has a preferentially exposed 200 crystal plane and exhibited dramatically enhanced activity, selectivity and stability as compared to conventional VPO catalysts and other state-of-the-art catalytic systems...
December 15, 2017: ChemSusChem
Zhiwei Zhao, Jun Huang, Zhangquan Peng
Lithium-air battery (LAB) is envisaged as an ultimate energy storage device because of its highest theoretical specific energy among all known battery chemistries. However, parasitic reactions bring about vexing issues on the efficiency and longevity of LAB, among which the formation and decomposition of lithium carbonate, Li_2 CO_3, is of paramount importance. The discovery of Li_2 CO_3 as the main discharge product in carbonate-based electrolytes once brought researchers to 'the end of the idyll' in the early 2010s...
December 15, 2017: Angewandte Chemie
Susumu Kitagawa
"New frontiers in chemistry must be built on a solid foundation because innovation is rooted in a firm understanding of traditional fields. However, researchers must ambitiously navigate unchartered areas. An open-minded attitude to learn traditional research fields will lead to new developments in these fields." The new Editorial Board Chairman Susumu Kitagawa shares his vision for the future of Chemistry-An Asian Journal.
December 15, 2017: Chemistry, An Asian Journal
Ftoon Alsaadi, Peter V Hodson, Valerie S Langlois
Canada has experienced a significant increase in the transport of diluted bitumen (dilbit), a predominant oil sands product that combines bitumen with diluents derived from oil-gas condensates and other proprietary compounds. The proportion of diluent and the chemical composition of dilbit vary to meet seasonal transport requirements. While the toxic effects of a variety of crude and refined oils are well-studied, the toxicity of dilbit to aquatic species is less well known. This focused review summarizes dilbit production, chemistry, and the few data on toxicity to aquatic species...
December 14, 2017: Bulletin of Environmental Contamination and Toxicology
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