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https://www.readbyqxmd.com/read/29031230/astatine-211-labeled-anti-her2-5f7-single-domain-antibody-fragment-conjugates-radiolabeling-and-preliminary-evaluation
#1
Jaeyeon Choi, Ganesan Vaidyanathan, Eftychia Koumarianou, Choong Mo Kang, Michael R Zalutsky
INTRODUCTION: Derived from heavy chain only camelid antibodies, ~15-kDa single-domain antibody fragments (sdAbs) are an attractive platform for developing molecularly specific imaging probes and targeted radiotherapeutics. The rapid tumor accumulation and normal tissue clearance of sdAbs might be ideal for use with (211)At, a 7.2-h half-life α-emitter, if appropriate labeling chemistry can be devised to trap (211)At in cancer cells after sdAb binding. This study evaluated two reagents, [(211)At]SAGMB and iso-[(211)At]SAGMB, for this purpose...
September 19, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29031153/facile-displacement-of-citrate-residues-from-gold-nanoparticle-surfaces
#2
Ganganath S Perera, Sumudu A Athukorale, Felio Perez, Charles U Pittman, Dongmao Zhang
The stability of citrate-residues on gold nanoparticles (AuNPs) against ligand displacement has been controversial. Using AuNPs synthesized with deuterated citrate in combination with in-situ surface-enhanced Raman spectroscopic (SERS) analysis, we report that both citrate-residues and solution impurities can be simultaneously adsorbed onto citrate-reduced AuNPs in solution. The citrate-residues can be readily displaced from AuNPs by organosulfur such as organothiols (RS-H), organodisuflide (R-S-S-R), and non-specific ligands including halides and adenine...
October 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29031128/electrochemically-mediated-in-situ-growth-of-electroactive-polymers-for-highly-sensitive-detection-of-double-stranded-dna-without-sequence-preference
#3
Qiong Hu, Qiangwei Wang, Jinming Kong, Lianzhi Li, Xueji Zhang
The ability to directly detect double-stranded DNA (dsDNA) without sequence-preference continues to be a major challenge. Herein, we report an electrochemical method for the direct, highly sensitive detection of dsDNA based on the strand replacement of dsDNA by peptide nucleic acid (PNA) and the in situ growth of electroactive polymers through the surface-initiated electrochemically mediated atom transfer radical polymerization (SI-eATRP). Thiolated PNA molecules are firstly self-assembled onto gold electrode surface for the specific recognition of target dsDNA (dsDNA-T), which in turn leads to the formation of a high density of PNA/DNA heteroduplexes on the electrode surface for the subsequent attachment of ATRP initiators via the phosphate-Zr(4+)-carboxylate chemistry...
September 28, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29031060/an-insight-into-the-biological-activities-of-heterocyclic-fatty-acid-hybrid-molecules
#4
REVIEW
Vijayendar Venepally, Ram Chandra Reddy Jala
Heterocyclic compounds are the interesting core structures for the development of new bioactive compounds. Fatty acids are derived from renewable raw materials and exhibit various biological activities. Several researchers are amalgamating these two bioactive components to yield bioactive hybrid molecules with some desirable features. Heterocyclic-fatty acid hybrid derivatives are a new class of heterocyclic compounds with a broad range of biological activities and significance in the field of medicinal chemistry...
October 3, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29031018/strategies-to-define-performance-specifications-in-laboratory-medicine-3-years-on-from-the-milan-strategic-conference
#5
Mauro Panteghini, Ferruccio Ceriotti, Graham Jones, Wytze Oosterhuis, Mario Plebani, Sverre Sandberg
Measurements in clinical laboratories produce results needed in the diagnosis and monitoring of patients. These results are always characterized by some uncertainty. What quality is needed and what measurement errors can be tolerated without jeopardizing patient safety should therefore be defined and specified for each analyte having clinical use. When these specifications are defined, the total examination process will be "fit for purpose" and the laboratory professionals should then set up rules to control the measuring systems to ensure they perform within specifications...
October 14, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29029351/development-and-application-of-a-dual-rat-and-human-ahr-activation-assay
#6
Martin R Brown, Helen Garside, Emma Thompson, Saseela Atwal, Chloe Bean, Tony Goodall, Michael Sullivan, Mark J Graham
Significant prolonged AHR activation, classically exhibited following exposure to TCDD (dioxin), can cause a variety of undesirable toxicological effects. Novel pharmaceutical chemistries also have the potential to cause activation of AHR and consequent toxicities in pre-clinical species and man. Previous methods either employed relatively expensive and low throughput primary hepatocyte dosing with PCR endpoint, or low resolution overexpressing reporter gene assays. We have developed, validated and applied an in vitro microtitre plate imaging-based medium throughput screening assay for the assessment of endogenous species-specific AHR activation potential via detection of induction of the surrogate transcriptional target Cytochrome P450 CYP1A1...
September 18, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29029316/the-need-for-and-the-role-of-the-toxicological-chemist-in-the-design-of-safer-chemicals
#7
Stephen C DeVito
During the past several decades there has been an ever increasing emphasis for designers of new commercial (non-pharmaceutical) chemicals to include considerations of the potential impacts a planned chemical may have on human health and the environment as part of the design of the chemical, and to design chemicals such that they possess the desired use efficacy while minimizing threats to human health and the environment. Achievement of this goal would be facilitated by the availability of individuals specifically and formally trained to design such chemicals...
September 18, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29029060/metagenomics-novel-enzymes-from-nonculturable-microbes
#8
Francesca Berini, Carmine Casciello, Giorgia Letizia Marcone, Flavia Marinelli
In the transition to the post-petroleum economy, there is a growing demand for novel enzymes with high process performances to replace traditional chemistry with a more 'green' approach. To date, microorganisms encompass the richest source of industrial biocatalysts, but the Earth-living microbiota remains largely untapped by using traditional isolation and cultivation methods. Metagenomics, which is culture-independent, represents a powerful tool for discovering novel enzymes from unculturable microorganisms...
October 4, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29028543/a-pulse-programmable-parahydrogen-polarizer-using-a-tunable-electromagnet-and-dual-channel-nmr-spectrometer
#9
Aaron M Coffey, Roman V Shchepin, Bibo Feng, Raul D Colon, Ken Wilkens, Kevin W Waddell, Eduard Y Chekmenev
Applications of parahydrogen induced polarization (PHIP) often warrant conversion of the chemically-synthesized singlet-state spin order into net heteronuclear magnetization. In order to obtain optimal yields from the overall hyperpolarization process, catalytic hydrogenation must be tightly synchronized to subsequent radiofrequency (RF) transformations of spin order. Commercial NMR consoles are designed to synchronize applied waves on multiple channels and consequently are well-suited as controllers for these types of hyperpolarization experiments that require tight coordination of RF and non-RF events...
September 30, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29028355/ion-transport-and-competition-effects-on-nati2-po4-3-and-na4mn9o18-selective-insertion-electrode-performance
#10
Sneha Shanbhag, Yousuf Bootwala, Jay F Whitacre, Meagan S Mauter
We evaluate the efficiency and capacity of electrochemically reversible insertion electrodes for use in targeted ion removal applications in aqueous solutions. The relative attributes of insertion material chemistry are evaluated by comparing the performance of two different sodium insertion materials NaTi2(PO4)3 and Na4Mn9O18 in different electrolyte environments. We performed experiments over a range of solution chemistries compositions containing both sodium and other non-inserting ions, and we then developed mechanistic insight into the effects of solution concentration and composition on overpotential losses and round trip coulombic efficiency...
October 13, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29028320/tunneling-control-of-chemical-reactions-the-third-reactivity-paradigm
#11
Peter R Schreiner
This Perspective describes the emergence of tunneling control as a new reactivity paradigm in chemistry. This term denotes a tunneling reaction that passes through a high but narrow potential energy barrier, leading to formation of a product that would be disfavored if the reaction proceeded by passage over kinetic barriers, rather than through them. This reactivity paradigm should be considered along with thermodynamic and kinetic control as a factor that can determine which of two or more possible products is likely to be the one obtained...
October 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29028313/anomalous-corrosion-of-bulk-transition-metal-diselenides-leading-to-stable-monolayers
#12
Yu-Ting Huang, Akhil Dodda, Daniel S Schulman, Amritanand Sebastian, Fu Zhang, Drew Buzzell, Mauricio Terrones, Shien-Ping Feng, Saptarshi Das
In this paper we provide insight into an anomalous corrosion process, referred to as electro-ablation (EA), which converts multi-layer flakes of transition metal diselenides like MoSe2 into their corresponding monolayers when micromechanically exfoliated on a conductive electrode and subsequently subjected to a high anodic potential inside a conventional electrochemical cell. Photoluminescence intensity map and scanning transmission electron microscopy (STEM) images confirmed the single crystalline nature and 2H-hexagonal lattice structure of the remnant monolayer MoSe2 flakes, indicating the superior corrosion stability of the monolayers compared to the bulk counterpart...
October 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29028298/ultrathin-nanocrystalline-diamond-films-with-silicon-vacancy-color-centers-via-seeding-by-2-nm-detonation-nanodiamonds
#13
Stepan Stehlik, Marian Varga, Pavla Štenclová, Lukáš Ondič, Martin Ledinsky, Jiří Pangrác, Ondrej Vanek, Jan Lipov, Alexander Kromka, Bohuslav Rezek
Color centers in diamond have shown excellent potential for applications in quantum information processing, photonics, and biology. Here we report chemical vapor deposition (CVD) growth of as thin as 5-6 nm nanocrystalline diamond (NCD) films with photoluminescence (PL) from silicon-vacancy (SiV) centers at 739 nm. Instead of conventional 4-6 nm detonation nanodiamonds (DNDs) we prepared and employed hydrogenated 2 nm DNDs (zeta potential +36 mV) to form extremely dense (~ 1.3 × 1013 cm-2), thin (2 ± 1 nm) and smooth (RMS roughness < 0...
October 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29028156/genetic-background-effects-in-neuroligin-3-mutant-mice-minimal-behavioral-abnormalities-on-c57-background
#14
Thomas C Jaramillo, Christine Ochoa Escamilla, Shunan Liu, Lauren Peca, Shari G Birnbaum, Craig M Powell
Neuroligin-3 (NLGN3) is a postsynaptic cell adhesion protein that interacts with presynaptic ligands including neurexin-1 (NRXN1) [Ichtchenko et al., Journal of Biological Chemistry, 271, 2676-2682, 1996]. Mice harboring a mutation in the NLGN3 gene (NL3R451C) mimicking a mutation found in two brothers with autism spectrum disorder (ASD) were previously generated and behaviorally phenotyped for autism-related behaviors. In these NL3R451C mice generated and tested on a hybrid C57BL6J/129S2/SvPasCrl background, we observed enhanced spatial memory and reduced social interaction [Tabuchi et al...
October 13, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29027977/participation-of-the-halogens-in-photochemical-reactions-in-natural-and-treated-waters
#15
REVIEW
Yi Yang, Joseph J Pignatello
Halide ions are ubiquitous in natural waters and wastewaters. Halogens play an important and complex role in environmental photochemical processes and in reactions taking place during photochemical water treatment. While inert to solar wavelengths, halides can be converted into radical and non-radical reactive halogen species (RHS) by sensitized photolysis and by reactions with secondary reactive oxygen species (ROS) produced through sunlight-initiated reactions in water and atmospheric aerosols, such as hydroxyl radical, ozone, and nitrate radical...
October 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29027923/plasmonic-nanomaterial-based-optical-biosensing-platforms-for-virus-detection
#16
REVIEW
Jaewook Lee, Kenshin Takemura, Enoch Y Park
Plasmonic nanomaterials (P-NM) are receiving attention due to their excellent properties, which include surface-enhanced Raman scattering (SERS), localized surface plasmon resonance (LSPR) effects, plasmonic resonance energy transfer (PRET), and magneto optical (MO) effects. To obtain such plasmonic properties, many nanomaterials have been developed, including metal nanoparticles (MNP), bimetallic nanoparticles (bMNP), MNP-decorated carbon nanotubes, (MNP-CNT), and MNP-modified graphene (MNP-GRP). These P-NMs may eventually be applied to optical biosensing systems due to their unique properties...
October 13, 2017: Sensors
https://www.readbyqxmd.com/read/29027722/the-coordination-and-supramolecular-chemistry-of-gold-metalloligands
#17
Juan Gil-Rubio, José Vicente
This review article deals with the use of gold metalloligands as building blocks for the assembly of heterometallic complexes. Several families of gold complexes decorated with crown-ether, amide, pyridine, bipyridine, terpyridine, carboxylato, aminoacid or pi-alkyne binding sites have been reported. Adducts of these metalloligands with alkaline or transition metal cations, or transition metal or lanthanide complexes, have been isolated and structurally characterized. The reported heterometallic species range from simple dinuclear complexes to self-assembled supramolecules, coordination polymers or solids...
October 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29027593/detecting-the-effects-of-coal-mining-acid-rain-and-natural-gas-extraction-in-appalachian-basin-streams-in-pennsylvania-usa-through-analysis-of-barium-and-sulfate-concentrations
#18
Xianzeng Niu, Anna Wendt, Zhenhui Li, Amal Agarwal, Lingzhou Xue, Matthew Gonzales, Susan L Brantley
To understand how extraction of different energy sources impacts water resources requires assessment of how water chemistry has changed in comparison with the background values of pristine streams. With such understanding, we can develop better water quality standards and ecological interpretations. However, determination of pristine background chemistry is difficult in areas with heavy human impact. To learn to do this, we compiled a master dataset of sulfate and barium concentrations ([SO4], [Ba]) in Pennsylvania (PA, USA) streams from publically available sources...
October 13, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/29027398/nutritional-status-cachexia-and-anorexia-in-women-with-peritoneal-metastasis-and-intraperitoneal-chemotherapy-a-longitudinal-analysis
#19
Ziad Hilal, Günther A Rezniczek, Robert Klenke, Askin Dogan, Clemens B Tempfer
OBJECTIVE: To describe the nutritional status of women with peritoneal metastasis (PM) from recurrent ovarian, fallopian, or peritoneal cancer and to assess longitudinal variations of the cachexia-anorexia syndrome (CAS) during palliative pressurized intraperitoneal aerosol chemotherapy (PIPAC). METHODS: Nutritional assessment included body mass index (BMI), bioelectrical impedance analysis (BIA), and blood chemistry. CAS presence/absence was recorded before and during repeated cycles (1-11) of PIPAC...
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29027275/multifaceted-supramolecular-interactions-from-c-methylresorcin-4-arene-lead-to-an-enhancement-in-in-vitro-antibacterial-activity-of-gatifloxacin
#20
Arnab Dawn, Harish Chandra, Chandra Ade-Browne, Jagjit Yadav, Harshita Kumari
Mimicking the antibacterial activity of polyphenols in synthetic systems is an attractive approach for the development of novel active pharmaceutical ingredients. Resorcinarenes represent a class of polyphenols which have been exploited for decades for their attractive chemical scaffold suitable for forming host-guest complexes with hydrophobic guest molecules. However, the polyphenolic character of resorcinarenes, which could be a potential asset to the pharmaceutical industry, have been least exploited. The present work represents an unprecedented interplay of chemical nature of resorcinarene conferring an antimicrobial activity together with its ability to interact with an antibacterial drug gatifloxacin, improving the overall antibacterial activity...
October 12, 2017: Chemistry: a European Journal
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