Sylvia Ranjeva, Alexander Nagebretsky, Gabriel Odozynski, Ana Fernandez-Bustamante, Gyorgy Frendl, R Alok Gupta, Juraj Sprung, Bala Subramaniam, Ricardo Martinez Ruiz, Karsten Bartels, Jadelis Giquel, Jae-Woo Lee, Timothy Houle, Marcos Francisco Vidal Melo
Intraoperative cardiopulmonary variables are well-known predictors of postoperative pulmonary complications (PPC), traditionally quantified by median values over the duration of surgery. However, it is unknown whether cardiopulmonary instability, or wider intra-operative variability of the same metrics, is distinctly associated with PPC risk and severity. We leveraged a retrospective cohort of adults (n = 1202) undergoing major non-cardiothoracic surgery. We used multivariable logistic regression to evaluate the association of two outcomes (1)moderate-or-severe PPC and (2)any PPC with two sets of exposure variables- (a)variability of cardiopulmonary metrics (inter-quartile range, IQR) and (b)median intraoperative cardiopulmonary metrics...
March 15, 2024: Journal of Medical Systems