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Coronary intervention

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https://www.readbyqxmd.com/read/29236216/long-term-outcomes-of-a%C3%A2-caucasian-cohort-presenting-with-acute-coronary-syndrome-and-or-out-of-hospital-cardiac-arrest-caused-by-coronary-spasm
#1
W Vlastra, M Piek, M A van Lavieren, M E J C Hassell, B E Claessen, G W Wijntjens, T P van de Hoef, K D Sjauw, M A Beijk, R Delewi, J J Piek
BACKGROUND: Coronary artery spasm may be the underlying mechanism in up to 10% of cases of acute coronary syndrome (ACS) and sudden cardiac death. Asian individuals exhibit a 3-times greater incidence of spasm than Caucasians; this is likely due to different types of mechanisms. Consequently, solid data is limited about the long-term prognosis in Caucasian patients presenting with ACS and/or out-of-hospital cardiac arrest (OHCA) caused by coronary spasm. METHODS: Between 2002 and 2015, thirty Caucasian patients with coronary artery spasm presenting with ACS (N = 29) and/or OHCA (N = 11) were enrolled in this prospective registry...
December 13, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/29236148/dual-antiplatelet-therapy-after-percutaneous-coronary-intervention-for-stable-cad-or-acs-redefining-the-optimal-duration-of%C3%A2-treatment
#2
B E Stähli, U Landmesser
The duration and combination of dual antiplatelet therapy after coronary stent implantation, consisting of aspirin and a P2Y12 inhibitor, is among the most intensely investigated therapeutic strategies in cardiovascular medicine. While initial studies have mainly focused on the efficacy and safety of individual antithrombotic agents, the increased need for a personalized, risk-based approach to define the optimal duration of antithrombotic treatment according to the estimated ischemic and bleeding risk was then recognized...
December 13, 2017: Herz
https://www.readbyqxmd.com/read/29236147/-platelet-inhibition-in-elderly-patients
#3
A Schäfer, J Bauersachs
Single antiplatelet therapy (SAPT) using predominantly acetylsalicylic acid (ASA) is the baseline anti-thrombotic therapy in primary as well as secondary prevention of atherosclerotic disease. Dual antiplatelet therapy (DAPT) is the cornerstone of maintenance medication following elective percutaneous coronary interventions or acute coronary syndromes (ST elevation myocardial infarction, non-ST elevation myocardial infarction and unstable angina pectoris). In the past the duration of DAPT in particular has been frequently discussed...
December 13, 2017: Herz
https://www.readbyqxmd.com/read/29234814/hormone-therapy-for-the-primary-prevention-of-chronic-conditions-in-postmenopausal-women-us-preventive-services-task-force-recommendation-statement
#4
David C Grossman, Susan J Curry, Douglas K Owens, Michael J Barry, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, Maureen G Phipps, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: Menopause occurs at a median age of 51.3 years, and the average US woman who reaches menopause is expected to live another 30 years. The prevalence and incidence of most chronic conditions, such as coronary heart disease, dementia, stroke, fractures, and breast cancer, increase with age; however, the excess risk for these conditions that can be attributed to menopause alone is uncertain. Since the publication of findings from the Women's Health Initiative that hormone therapy use is associated with serious adverse health effects in postmenopausal women, use of menopausal hormone therapy has declined...
December 12, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29234452/genetic-variations-of-cholesteryl-ester-transfer-protein-and-diet-interactions-in-relation-to-lipid-profiles-and-coronary-heart-disease-a-systematic-review
#5
REVIEW
Parvin Mirmiran, Zohre Esfandiar, Firoozeh Hosseini-Esfahani, Gelareh Koochakpoor, Maryam S Daneshpour, Bahar Sedaghati-Khayat, Fereidoun Azizi
Data on diet-genotype interactions in the prevention or treatment of dyslipidemia have increased remarkably. This systematic review aimed to assess nutrigenetic studies regarding the modulating effect of diet on cholesteryl ester transfer protein (CETP) polymorphisms in relation to metabolic traits. Data were collected through studies published between 2000 and SEP. 2016 using five electronic databases. The quality of eligible studies was assessed using a 12-item quality checklist, derived from the STrengthening the REporting of Genetic Association Studies (STREGA) statement...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29233364/epicardial-15-mhz-echocardiography-for-effective-repair-of-coronary-arteriovenous-fistula
#6
Masashi Komeda, Hirotomo Uchiyama, Sakurako Nakamura, Takashi Kusunose, Shoji Fujiwara, Toshimi Ujiie
In the era of catheter intervention, the surgical repair of coronary arteriovenous fistula needs to be free from residual shunt. Intraoperative epicardial 15-MHz echocardiography helps to find the residual shunt after ligation or obliteration of anomalous vessels. Here we report our method of the echo-assisted surgical repair of coronary arteriovenous fistula in 7 adult patients. The method made the operation for coronary arteriovenous fistula free from residual shunt, but care should be taken to the development of new vessels after the operation...
January 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29233197/takayasu-arteritis-in-paediatrics
#7
Marisa Di Santo, Erica V Stelmaszewski, Alejandra Villa
Takayasu arteritis is an idiopathic chronic granulomatous panarteritis predominantly affecting the aorta and its main branches. Although idiopathic, genetic contribution to disease susceptibility is being increasingly recognised. Rare in children, Takayasu arteritis is a worldwide disease with significant morbidity and mortality. Its diagnosis is a challenge and requires awareness of the condition as clinical features at presentation are non-specific and assessing disease activity is difficult. In the inflammatory stage, treatment is essential to prevent the insidious course and vascular damage: stenotic, occlusive lesions, aneurysms, and aortic regurgitation...
December 13, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/29233155/a-meta-model-for-computer-executable-dynamic-clinical-safety-checklists
#8
Shan Nan, Pieter Van Gorp, Xudong Lu, Uzay Kaymak, Hendrikus Korsten, Richard Vdovjak, Huilong Duan
BACKGROUND: Safety checklist is a type of cognitive tool enforcing short term memory of medical workers with the purpose of reducing medical errors caused by overlook and ignorance. To facilitate the daily use of safety checklists, computerized systems embedded in the clinical workflow and adapted to patient-context are increasingly developed. However, the current hard-coded approach of implementing checklists in these systems increase the cognitive efforts of clinical experts and coding efforts for informaticists...
December 12, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29233087/stroke-prevention-rehabilitation-intervention-trial-of-exercise-sprite-a-randomised-feasibility-study
#9
Neil Heron, Frank Kee, Jonathan Mant, Philip M Reilly, Margaret Cupples, Mark Tully, Michael Donnelly
BACKGROUND: The value of cardiac rehabilitation (CR) after a transient ischaemic attack (TIA) or minor stroke is untested despite these conditions sharing similar pathology and risk factors to coronary heart disease. We aimed to evaluate the feasibility of conducting a trial of an adapted home-based CR programme, 'The Healthy Brain Rehabilitation Manual', for patients following a TIA/minor stroke, participants' views on the intervention and, to identify the behaviour change techniques (BCTs) used...
December 12, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29232970/primary-coronary-intervention-in-octogenarians-and-nonagenarians-with-st-segment-elevation-myocardial-infarction-a-canadian-single-center-perspective
#10
Rajat Sharma, Brett Hiebert, David Cheung, Davinder S Jassal, Kunal Minhas
The proportion of individuals >80 years of age constitute an increasing proportion of patients who present with ST-segment elevation myocardial infarction (STEMI). The objective of this study is to evaluate in-hospital outcomes and 1-year survival of very elderly patients who present with an STEMI and undergo primary percutaneous coronary intervention (pPCI). Between 2009 and 2015, individuals >80 years of age (very elderly patients) with an STEMI presenting at a single tertiary Canadian care center were included in the study...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/29231917/stable-coronary-artery-disease-medical-treatment
#11
REVIEW
Rafał Dąbrowski, Marcin Dobrowolski
The crucial issues in optimal medical therapy to improve prognosis and reduce angina symptoms are secondary prevention, effective control of concomitant diseases, risk factors and medical treatment. In spite of successful percutaneous coronary interventions (PCI) and medical treatment with beta-blockers, ACE-inhibitors or angiotensin receptor blockers, statins and antiplatelet drugs, some patients are still symptomatic. In the era of PCI not sufficient attention is paid to other drugs reducing the incidence of angina episodes: calcium antagonists, long-acting nitrates, metabolic agents and novel antianginal drugs...
November 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29230597/presence-of-post-systolic-shortening-is-an-independent-predictor-of-heart-failure-in-patients-following-st-segment-elevation-myocardial-infarction
#12
Philip Brainin, Sune Haahr-Pedersen, Morten Sengeløv, Flemming Javier Olsen, Thomas Fritz-Hansen, Jan Skov Jensen, Tor Biering-Sørensen
Following an ischemic event post systolic shortening (PSS) may occur. We investigated the association between PSS in patients with ST-segment elevation myocardial infarction (STEMI) following primary percutaneous coronary intervention (pPCI) and occurrence of cardiovascular events at follow-up. A total of 373 patients admitted with STEMI and treated with pPCI were prospectively included in the study cohort. All patients were examined by echocardiography a median of 2 days after admission (interquartile range, 1-3 days)...
December 11, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29230180/immediate-early-vs-delayed-invasive-strategy-for-patients-with-non-st-segment-elevation-acute-coronary-syndromes-a-systematic-review-and-meta-analysis
#13
REVIEW
Yanda Li, Zhenpeng Zhang, Xingjiang Xiong, William C Cho, Dan Hu, Yonghong Gao, Hongcai Shang, Yanwei Xing
Invasive coronary revascularization has been shown to improve prognoses in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS), but the optimal timing of intervention remains unclear. This meta-analysis is to evaluate the outcomes in immediate (<2 h), early (<24 h), and delayed invasive group and find out which is the optimal timing of intervention in NSTE-ACS patients. Studies were identified through electronic literature search of Medline, PubMed Central, Embase, the Cochrane Library, and CNKI...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29229216/immediate-complete-revascularization-in-patients-with-st-segment-elevation-myocardial-infarction-and-multivessel-disease-treated-by-primary-percutaneous-coronary-intervention-insights-from-the-orbi-registry
#14
Anna Pimor, Vincent Auffret, Romain Didier, Régis Delaunay, Emmanuelle Filippi, Jean-Philippe Hacot, Djamel Saouli, Gilles Rouault, Philippe Druelles, Emilie Bot, Isabelle Coudert, Bertrand Boulanger, Marielle Le Guellec, Dominique Boulmier, Guillaume Leurent, Marc Bedossa, Martine Gilard, Hervé Le Breton
BACKGROUND: Recent studies demonstrated the superiority of complete revascularization (CR) in patients treated by primary percutaneous coronary intervention (pPCI) in ST-elevation myocardial infarction (STEMI). AIM: To evaluate whether immediate CR improves in-hospital outcomes in patients with STEMI with multivessel disease. METHODS: Data from a prospective multicentre registry including 9365 patients with STEMI were analysed. Patients with multivessel disease and treated with pPCI (n=3412) were included and separated into two groups according to whether immediate CR was performed during the index procedure...
December 8, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29228817/cangrelor-in-percutaneous-coronary-intervention-current-status-and-perspectives
#15
Dimitrios Alexopoulos, Christos Pappas, Danai Sfantou, John Lekakis
Cangrelor is an intravenously administered P2Y12 receptor antagonist with very fast, potent, and quickly reversible action. In the CHAMPION PHOENIX trial, cangrelor provided an improved anti-ischemic protection compared with clopidogrel, without increasing the risk of severe bleeding. Cangrelor is currently approved by drug regulating authorities for patients undergoing percutaneous coronary intervention (PCI) without prior treatment with a P2Y12 receptor antagonist and not receiving a glycoprotein IIb/IIIa inhibitor, while its use is endorsed with a class IIb recommendation by the European Society of Cardiology guidelines...
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29228000/an-in-vivo-assessment-of-the-cholesterol-lowering-efficacy-of-lactobacillus-plantarum-ecgc-13110402-in-normal-to-mildly-hypercholesterolaemic-adults
#16
Adele Costabile, Ivan Buttarazzi, Sofia Kolida, Sara Quercia, Jessica Baldini, Jonathan R Swann, Patrizia Brigidi, Glenn R Gibson
Coronary heart disease (CHD) is one of the major causes of death and disability in industrialised countries, with elevated blood cholesterol an established risk factor. Total plasma cholesterol reduction in populations suffering from primary hypercholesterolemia may lower CHD incidence. This study investigated the cholesterol reducing capacity of Lactobacillus plantarum ECGC 13110402, a strain selected for its high bile salt hydrolase activity, in 49 normal to mildly hypercholesterolaemic adults. Primary efficacy outcomes included effect on blood lipids (total cholesterol (TC), low density lipoproteins (LDL-C), high density lipoproteins (HDL-C) and triacylgycerides (TAG), inflammatory biomarkers and occurrence/severity of gastrointestinal side effects to establish safety and tolerance of the intervention...
2017: PloS One
https://www.readbyqxmd.com/read/29227975/high-phosphate-induced-calcification-of-vascular-smooth-muscle-cells-is-associated-with-the-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway
#17
Daohai Zhang, Xianjin Bi, Yong Liu, Yinghui Huang, Jiachuan Xiong, Xinli Xu, Tangli Xiao, Yanlin Yu, Wei Jiang, Yunjian Huang, Jingbo Zhang, Bo Zhang, Jinghong Zhao
BACKGROUND/AIMS: Hyperphosphatemia is one of the most notable features of chronic kidney disease (CKD). Numerous epidemiological and clinical studies have found that high serum phosphate concentrations are associated with calcification in the coronary arteries. However, the mechanisms underlying the vascular calcification induced by high phosphate have not been understood fully. METHODS: Vascular smooth muscle cells (VSMCs) were cultured in high-phosphate media to induce vascular calcification, which was detected by Alizarin red S staining...
December 8, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29226895/a-late-complication-of-coronary-artery-perforation-during-primary-percutaneous-coronary-intervention-coronary-arteriovenous-fistula
#18
Kayıhan Karaman, Metin Karayakalı, Arif Arısoy, İlker Akar, Ataç Çelik
Coronary artery perforation (CAP) is a rare, but potentially mortal possible complication of percutaneous coronary intervention. There are several treatment options for this complication, including prolonged balloon dilatation, use of a coronary stent graft, and bypass surgery. In this case report, a 65-year-old female patient who was admitted to the catheter laboratory with a diagnosis of acute coronary syndrome, was presented. Coronary angiography revealed total occlusion in the mid segment of the right coronary artery and a drug-eluting stent was implanted under 12 atm of pressure following pre-dilatation with a perfusion balloon...
December 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29226890/relationship-between-the-extent-of-coronary-artery-disease-and-in-stent-restenosis-in-patients-with-acute-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#19
Erkan Yıldırım, Murat Çelik, Uygar Çağdaş Yüksel, Barış Buğan, Yalçın Gökoğlan, Suat Görmel, Salim Yaşar, Mustafa Koklu, Atila İyisoy, Cem Barçın
OBJECTIVE: The pathophysiological mechanism of in-stent restenosis (ISR) is different from atherosclerosis of native coronary arteries. The aim of this study was to evaluate the relationship between ISR and the extent of coronary artery disease (CAD), and to identify other risk factors associated with ISR in ST-segment elevation myocardial infarction (STEMI) patients. METHODS: A total of 372 consecutive patients presenting with first acute STEMI who were successfully treated with primary percutaneous coronary intervention within 12 hours from the onset of symptoms and who had an angiographic follow-up at 3 months were included in the study...
December 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29226578/ischemia-reperfusion-injury-and-ischemic-post-conditioning-in-acute-myocardial-infarction-lost-in-translation
#20
EDITORIAL
Gennaro Giustino, George D Dangas
Ischemic post-conditioning (IPoC) has been proposed as a strategy to mitigate the risk of ischemia-reperfusion injury during primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI). In this comprehensive and updated meta-analysis of randomized controlled trials, IPoC during primary PCI for STEMI had no significant effect on all-cause mortality, re-infarction, or new-onset heart failure compared with no post-conditioning. Further strategies need to be prospectively evaluated to improve outcomes in patients with STEMI undergoing primary PCI...
December 1, 2017: Catheterization and Cardiovascular Interventions
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