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Francielly Mourão Gasparotto, Francislaine Aparecida Dos Reis Lívero, Rhanany Allan Caloi Palozi, Maria Leticia Ames, Bruna Nunes, Guilherme Donadel, Rita de Cassia Lima Ribeiro, Emerson Luiz Botelho Lourenço, Cândida Aparecida Leite Kassuya, Arquimedes Gasparotto Junior
Excess weight and dyslipidemia are among the most serious health problems in Western societies. These conditions enhance the risk of cardiac disease and have been linked with a higher prevalence of cardiac arrhythmias and sudden death. The present study investigated the cardioprotective effects of Echinodorus grandiflorus on ventricular remodeling in rabbits that were fed a 1% cholesterol-rich diet. We first obtained an ethanol-soluble fraction of E. grandiflorus and performed a detailed phytochemical study by liquid chromatography-DAD/ESI-MS...
June 21, 2018: Planta Medica
Rujiao Dong, Guibo Ma, Shunji Zhang, Yujuan Gao, Shuchuan Liu, Yanhua Su
: The introduction of new agents in multiple myeloma therapy has increased the overall response rate and improved clinical outcomes, but the increased risk of thrombotic complications impairs the quality of life of patient and the optimal thromboprophylaxis remains unknown. Increasing evidence has shown that statins can prevent venous thrombosis. Hence, we investigated the effects of simvastatin on multiple myeloma serum-related haemostatic imbalance in endothelial cells in vitro. The effects of simvastatin on procoagulant and anticoagulant protein expression were assessed on mixed multiple myeloma serum-treated human umbilical vein endothelial cells (HUVECs)...
June 18, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
Maryam Mohammadian, Hamid Reza Sadeghipour, Gila Pirzad Jahromi, Mahvash Jafari, Amir Kavian Nejad, Safoura Khamse, Mohammad Hossein Boskabady
INTRODUCTION: The effects of bone marrow-derived mesenchymal stem cells (BMSCs) and simvastatin combination therapy on serum total and specific IgE levels and lung IL-13 and TGF-β levels in sensitized mouse were examined. MATERIAL AND METHODS: Control (n = 5), Sensitized (S), (n = 5), S + BMSC (n = 6), S + simvastatin (n = 6) and S + BMSC + simvastatin (n = 4) groups of BALB/c mice were studied. Mice were sensitized by ovalbumin...
June 15, 2018: Cytokine
Martina T Ayad, Brandie D Taylor, Ramkumar Menon
PROBLEM: Oxidative stress (OS)-induced, p38 mitogen-activated protein kinase (p38MAPK)-mediated chorioamniotic senescence and inflammation (senescence-associated secretory phenotype [SASP]) are associated with parturition. In response to OS-inducing risk factors, premature senescence contributes to preterm premature rupture of the membranes (pPROM) and spontaneous preterm birth (PTB). We determined the effect of simvastatin, rosuvastatin, and progesterone in downregulating p38MAPK-mediated senescence and SASP...
June 17, 2018: American Journal of Reproductive Immunology: AJRI
Tracey G Simon, Kathleen E Corey, Christopher P Cannon, Michael Blazing, Jeong-Gun Park, Michelle L O'Donoghue, Raymond T Chung, Robert P Giugliano
OBJECTIVE: The nonalcoholic fatty liver disease fibrosis score (NFS) is comprised of unique metabolic risk indicators that may accurately predict residual cardiovascular (CV) risk in patients with established coronary disease and metabolic dysfunction. METHODS: We applied the NFS prospectively to 14,819 post-ACS patients randomized to ezetimibe/simvastatin (E/S) or placebo/simvastatin (P/S), in the IMPROVE-IT trial, using validated NFS cutoffs. The primary endpoint included CV death, myocardial infarction, unstable angina, revascularization or stroke...
May 26, 2018: International Journal of Cardiology
Jéssica Suzuki Yamanaka, Kaique Eduardo Carvalho Ribeiro, Gabriela Rezende Yanagihara, Antônio Carlos Shimano, Álvaro César de Oliveira Penoni
Objective: The aim of the present study was to evaluate the influence of simvastatin on mechanical properties of muscle and bone in hypercholesterolemic rats submitted to physical exercise. Methods: Ten male Wistar rats were submitted to a high-fat diet rich in cholesterol for 90 days. The animals were then divided into two groups: animals treated with physical exercise (EG) and animals treated with physical exercise and simvastatin (ESG). Protocols for physical exercise in water and simvastatin administration were performed for eight weeks...
May 2018: Revista Brasileira de Ortopedia
Fatemeh Namazi, Tahoora Shomali, Pouya Taghikhani, Saied Nazifi
Objective: Finding compounds that could be used for prevention of atherosclerosis (AS) is highly desired. The present study evaluated the protective effects of Urtica dioica (UD, commonly known as stinging nettle) leaf ethanolic extract against high-fat diet-induced AS in rats. Materials and Methods: In this study, 40 male adult Sprauge-Dawley rats were randomly allocated to 4 equal groups and treated as follows for 9 consecutive weeks: (1) Normal control (NC; normal rats that were fed with a basic diet); (2) Atherosclerotic rats (AT; which received no particular treatment); (3) Atherosclerotic rats that received 100 mg/kg/day ethanolic extract of UD orally and (4) Atherosclerotic rats that received simvastatin 4 mg/kg/day orally...
May 2018: Avicenna Journal of Phytomedicine
Susana Barros, Rosa Montes, José Benito Quintana, Rosario Rodil, Ana André, Ana Capitão, Joana Soares, Miguel M Santos, Teresa Neuparth
Simvastatin (SIM), a hypocholesterolaemic compound, is among the most prescribed pharmaceuticals for cardiovascular disease prevention worldwide. Several studies have shown that acute exposure to SIM causes multiple adverse effects in aquatic organisms. However, uncertainties still remain regarding the chronic effects of SIM in aquatic ecosystems. Therefore, the present study aimed to investigate the effects of SIM in the model freshwater teleost zebrafish (Danio rerio) following a chronic exposure (90 days) to environmentally relevant concentrations ranging from 8 ng/L to 1000 ng/L...
May 25, 2018: Aquatic Toxicology
Huichun Tong, Xiuping Zhang, Xingjun Meng, Lingli Lu, Dongmei Mai, Shaogang Qu
Evidence suggests that oxidative stress is involved in the pathogenesis of Parkinson disease (PD). Simvastatin has been suggested to protect against oxidative stress in several diseases. However, the molecular mechanisms by which simvastatin protects against neuropathology and oxidative damage in PD are poorly elucidated. In this study, we aimed to investigate the potential neuroprotective effects of simvastatin owing to its anti-oxidative properties in 6-hydroxydopamine (6-OHDA)-treated SH-SY5Y cells and mice...
2018: Frontiers in Molecular Neuroscience
D I Tomilova, Y A Karpov, V V Lopukhova
PURPOSE: To study adherence to therapy with statins and its relation to development of cardio-vascular complications (CVC) in patients with stable angina after elective percutaneous coronary intervention (PCI) at five-year observation. MATERIALS AND METHODS: This study comprised 574 patients with stable angina (81 % men, mean age 60.3 years) hospitalized for elective PCI. All patients were prescribed therapy in accordance with recommendations on management of stable angina including statins...
May 2018: Kardiologiia
Emma P Deloughery, Vinay Prasad
No abstract text is available yet for this article.
June 4, 2018: Journal of General Internal Medicine
Fu-Chen Huang, Shun-Chen Huang
Alternative therapies are needed to reduce the use of antibiotics and incidence of drug-resistant Salmonellosis . Previous studies have revealed important roles of statins in regulating innate immunity. Therefore, we investigated the effects of statins on innate immunity in Salmonella -infected intestinal epithelial cells (IECs), which are involved in mucosal innate immunity. SW480 cells and Akt siRNA- or vitamin D receptor (VDR) siRNA-transfected SW480 cells were infected by wild-type S. Typhimurium strain SL1344 in the presence or absence of statins...
June 2, 2018: International Journal of Molecular Sciences
Wan-Yun Gao, Pei-Yi Chen, Shih-Fen Chen, Ming-Jiuan Wu, Heng-Yuan Chang, Jui-Hung Yen
Pinostrobin, a flavonoid phytochemical found in variety of plants, has been demonstrated to possess numerous bioactivities such as anti-oxidant, anti-inflammatory, anti-cancer and neuroprotective properties. The aim of this study was to investigate the hypocholesterolemic effect of pinostrobin on the regulation of the gene expression of PCSK9 and its underlying mechanisms in hepatic cells. We found that pinostrobin (20 and 40 μM) significantly inhibited the PCSK9 promoter activity from 1.00 ± 0.16 (fold) to 0...
June 4, 2018: Journal of Agricultural and Food Chemistry
Nawal M Al-Rasheed, Nouf M Al-Rasheed, Yieldez A Bassiouni, Iman H Hasan, Maha A Al-Amin, Hanaa N Al-Ajmi, Ayman M Mahmoud
Statins are HMG-CoA reductase inhibitors with lipid-lowering effect and commonly used to reduce cardiovascular risk in diabetic patients. The present study investigates the ameliorative effect of simvastatin (SIM) on diabetic nephropathy in rats, pointing to its anti-apoptotic and anti-oxidative stress efficacies. Diabetes was induced by a single intraperitoneal injection of 55 mg/kg body weight streptozotocin (STZ) and both control and diabetic rats received 10 mg/kg SIM for 90 days. Treatment with SIM diminished the body weight loss, blood glucose and, serum creatinine, urea and uric acid in diabetic rats...
May 31, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Annette Wegner, Dragan Pavlovic, Sebastian Haußmann-Vopel, Christian Lehmann
It has been observed, that patients who were treated medically for dyslipoproteinemia had a potentially lower risk of complications during infection and sepsis, regarding both morbidity and mortality. Aim of this study in experimental sepsis was to elucidate the impact of lipid metabolism modulation by simvastatin, HDL, or bezafibrate, respectively, on the intestinal microcirculation which plays a crucial role in the development of multiple organ failure in sepsis. Experimental sepsis was induced in Lewis rats by intravenous lipopolysaccharide (LPS) administration...
May 31, 2018: Microvascular Research
Saikrishna Degala, Nikita A Bathija
PURPOSE: Simvastatin has been reported to promote osteoblastic activity, inhibit osteoclastic activity, and support osteoblast differentiation induced by bone morphogenetic protein. This split-mouth randomized clinical trial evaluated the effect of local application of simvastatin (10 mg) on bone regeneration after surgical removal of bilaterally impacted mandibular third molars. MATERIALS AND METHODS: A randomized, split-mouth, single-blinded, single-center trial was performed in 30 patients 18 to 40 years old requiring surgical extraction of bilaterally impacted mandibular third molars...
May 30, 2018: Journal of Oral and Maxillofacial Surgery
Nattaphol Uransilp, Pannawat Chaiyawatthanananthn, Sombat Muengtaweepongsa
Backgrounds: Stroke is the leading cause of death and long-term disability. Oxidative stress is elevated during occurrence of acute ischemic stroke (AIS). Soluble LOX-1 (sLOX-1) and NO are used as biomarkers for vascular oxidative stress that can reflect stabilization of atherosclerotic plaque. Previous study showed that simvastatin can reduce oxidative stress and LOX-1 expression. Objectives: To evaluate neurological outcomes and serum sLOX-1 and NO levels in patients with AIS treatment with low dose 10 mg/day and high dose 40 mg/day of simvastatin...
2018: Neurology Research International
Sumie Kato, María Francisca Liberona, Javier Cerda-Infante, Marianela Sanchez, Jenny F Henriquez, Carolina Bizama, Maria Loreto Bravo, Pamela Gonzalez, Roger Gejman, Jorge Branes, Karen García, Carolina Ibañez, Gareth Ivor Owen, Juan Carlos Roa, Viviana Montecinos, Mauricio Arturo Cuello
Cell plasticity of 'stem-like' cancer-initiating cells (CICs) is a hallmark of cancer, allowing metastasis and cancer progression. Here, we studied whether simvastatin, a lipophilic statin, could impair the metastatic potential of CICs in high-grade serous ovarian cancer (HGS-ovC), the most lethal among the gynecologic malignancies. qPCR, immunoblotting, and immunohistochemistry were used to assess simvastatin effects on proteins involved in stemness and epithelial-mesenchymal cell plasticity (EMT). Its effects on tumor growth and metastasis were evaluated using different models (e...
May 30, 2018: Endocrine-related Cancer
Aaron Eskinazi-Budge, Dharani Manickavasagam, Tori Czech, Kimberly Novak, James Kunzler, Moses O Oyewumi
Simvastatin (Sim) is a widely known drug in the treatment of hyperlipidemia that has attracted so much attention in bone regeneration based on its potential osteoanabolic effect. However, repurposing of Sim in bone regeneration will require suitable delivery systems that can negate undesirable off-target/side effects. In this study, we have investigated a new lipid nanoparticle (NP) platform that was fabricated using a binary blend of emulsifying wax (Ewax) and glyceryl monooleate (GMO). Using the binary matrix materials, NPs loaded with Sim (0-500 µg/mL) were prepared and showed an average particle size of about 150 nm...
May 30, 2018: Drug Development and Industrial Pharmacy
Hyunjin Lee, Hyuna Lee, Chae-Bin Na, Jun-Beom Park
PURPOSE: This study evaluates the effects of simvastatin on the morphology, viability, secretion of vascular endothelial growth factor (VEGF) and expression of stemness markers and messenger RNA of cell spheroids cultured in growth media. MATERIALS AND METHODS: Three-dimensional cell spheroids with stem cells and osteoblast-like cells were fabricated using concave, silicon, elastomer-based microwells in the presence of simvastatin at concentrations of 1 and 10 μM...
May 24, 2018: Implant Dentistry
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