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JOURNAL ARTICLE
Bruce van Dijk, Sabrina Oliveira, J Fred F Hooning van Duyvenbode, F Ruben H A Nurmohamed, Vida Mashayekhi, Irati Beltrán Hernández, Jos van Strijp, Lisanne de Vor, Piet C Aerts, H Charles Vogely, Harrie Weinans, Bart C H van der Wal
INTRODUCTION: Implant infections caused by Staphylococcus aureus are responsible for high mortality and morbidity worldwide. Treatment of these infections can be difficult especially when bacterial biofilms are involved. In this study we investigate the potential of infrared photoimmunotherapy to eradicate staphylococcal infection in a mouse model. METHODS: A monoclonal antibody that targets Wall Teichoic Acid surface components of both S. aureus and its biofilm (4497-IgG1) was conjugated to a photosensitizer (IRDye700DX) and used as photoimmunotherapy in vitro and in vivo in mice with a subcutaneous implant pre-colonized with biofilm of Staphylococcus aureus...
2024: PloS One
#2
JOURNAL ARTICLE
Mohit K Turagam, Petr Neuzil, Boris Schmidt, Tobias Reichlin, Kars Neven, Andreas Metzner, Jim Hansen, Yuri Blaauw, Philippe Maury, Thomas Arentz, Philipp Sommer, Ante Anic, Frederic Anselme, Serge Boveda, Tom Deneke, Stephan Willems, Pepijn van der Voort, Roland Tilz, Moritoshi Funasako, Daniel Scherr, Reza Wakili, Daniel Steven, Josef Kautzner, Johan Vijgen, Pierre Jais, Jan Petru, Julian Chun, Laurent Roten, Anna Füting, Marc D Lemoine, Martin Ruwald, Bart A Mulder, Anne Rollin, Heiko Lehrmann, Thomas Fink, Zrinka Jurisic, Corentin Chaumont, Raquel Adelino, Karin Nentwich, Melanie Gunawardene, Alexandre Ouss, Christian-Hendrik Heeger, Martin Manninger, Jan-Eric Bohnen, Arian Sultan, Petr Peichl, Pieter Koopman, Nicolas Derval, Thomas Kueffer, Nico Reinsch, Vivek Y Reddy
BACKGROUND: Pulmonary vein isolation (PVI) alone is insufficient to treat many patients with persistent atrial fibrillation (PersAF). Adjunctive left atrial posterior wall (LAPW) ablation with thermal technologies has revealed lack of efficacy, perhaps limited by the difficulty in achieving lesion durability amid concerns of esophageal injury. OBJECTIVES: This study aims to compare the safety and effectiveness of PVI + LAPW ablation vs PVI in patients with PersAF using pulsed-field ablation (PFA)...
January 31, 2024: JACC. Clinical Electrophysiology
#3
JOURNAL ARTICLE
Marco Guglielmo, Sophie Rier, Giulia De Zan, Axel J Krafft, Michaela Schmidt, Karl P Kunze, Rene M Botnar, Claudia Prieto, Jeroen van der Heijden, Vincent Van Driel, Hemanth Ramanna, Pim van der Harst, Ivo van der Bilt
BACKGROUND: Incomplete atrial lesions resulting in pulmonary vein-left atrium reconnection after pulmonary vein antrum isolation (PVAI), are related to atrial fibrillation (AF) recurrence. Unfortunately, during the PVAI procedure, fluoroscopy and electroanatomic mapping cannot accurately determine the location and size of the ablation lesions in the atrial wall and this can result in incomplete PVAI lesions (PVAI-L) after radiofrequency catheter ablation (RFCA). AIM: We seek to evaluate whether cardiac magnetic resonance (CMR), immediately after RFCA of AF, can identify PVAI-L by characterizing the left atrial tissue...
December 8, 2023: Journal of Cardiovascular Electrophysiology
#4
JOURNAL ARTICLE
Maartje J M Hereijgers, Rachel M J van der Velden, Nora El Moussaoui, Dominique V M Verhaert, Zarina Habibi, Justin Luermans, Dennis den Uijl, Sevasti-Maria Chaldoupi, Kevin Vernooy, Ulrich Schotten, Mathias Baumert, Hester A Gietema, Casper Mihl, Lukasz Koltowski, Frits M E Franssen, Sami O Simons, Dominik Linz
BACKGROUND: In atrial fibrillation (AF) patients, presence of expiratory airflow limitation may negatively impact treatment outcomes. AF patients are not routinely screened for expiratory airflow limitation, but existing examinations can help identify at-risk individuals. We aimed to assess the diagnostic value of repurposing existing assessments from the pre-ablation work-up to identify and understand the characteristics of affected patients. METHODS: We screened 110 consecutive AF patients scheduled for catheter ablation with handheld spirometry...
December 2023: IJC Heart & Vasculature
#5
JOURNAL ARTICLE
Boris Schmidt, Stefano Bordignon, Kars Neven, Tobias Reichlin, Yuri Blaauw, Jim Hansen, Raquel Adelino, Alexandre Ouss, Anna Füting, Laurent Roten, Bart A Mulder, Martin H Ruwald, Roberto Mené, Pepijn van der Voort, Nico Reinsch, Thomas Kueffer, Serge Boveda, Elizabeth M Albrecht, Christopher W Schneider, K R Julian Chun
BACKGROUND AND AIMS: Pulsed field ablation (PFA) is a new, non-thermal ablation modality for pulmonary vein isolation (PVI) in patients with atrial fibrillation (AF). The multi-center EU-PORIA (EUropean Real World Outcomes with Pulsed Field AblatiOn in Patients with Symptomatic AtRIAl Fibrillation) registry sought to determine the safety, efficacy, and learning curve characteristics for the pentaspline, multielectrode PFA catheter. METHODS: All-comer AF patients from seven high-volume centers were consecutively enrolled...
June 28, 2023: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#6
JOURNAL ARTICLE
Claudia A J van der Heijden, Vanessa Weberndörfer, Mindy Vroomen, Justin G Luermans, Sevasti-Maria Chaldoupi, Elham Bidar, Kevin Vernooy, Jos G Maessen, Laurent Pison, Sander M J van Kuijk, Mark La Meir, Harry J G M Crijns, Bart Maesen
BACKGROUND: Although catheter ablation (CA) is successful for the treatment of paroxysmal atrial fibrillation (AF), results are less satisfactory in persistent AF. Hybrid ablation (HA) results in better outcomes in patients with persistent atrial fibrillation (persAF), as it combines a thoracoscopic epicardial and transvenous endocardial approach in a single procedure. OBJECTIVES: The purpose of this study was to compare the effectiveness and safety of HA with CA in a prospective, superiority, unblinded, randomized controlled trial...
January 10, 2023: JACC. Clinical Electrophysiology
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JOURNAL ARTICLE
Claudia A J van der Heijden, Vanessa Weberndörfer, Justin G L M Luermans, Sander M J van Kuijk, Mindy Vroomen, Elham Bidar, Jos G Maessen, Laurent Pison, Mark La Meir, Bart Maesen
BACKGROUND: Hybrid ablation (HA) of atrial fibrillation (AF) combines minimally invasive thoracoscopic epicardial ablation with transvenous endocardial electrophysiologic validation and touch-up of incomplete epicardial lesions if needed. While studies have reported on a bilateral thoracoscopic HA approach, data on a unilateral left-sided approach are scarce. AIM: To evaluate the efficacy and safety of a unilateral left-sided thoracoscopic approach. METHODS: Retrospective analysis of a prospectively gathered cohort of all consecutive patients undergoing a unilateral left-sided HA for AF between 2015 and 2018 in the Maastricht University Medical Centre...
November 9, 2022: Journal of Cardiac Surgery
#8
JOURNAL ARTICLE
Lisanne de Vor, Bruce van Dijk, Kok van Kessel, Jeffrey S Kavanaugh, Carla de Haas, Piet C Aerts, Marco C Viveen, Edwin C Boel, Ad C Fluit, Jakub M Kwiecinski, Gerard C Krijger, Ruud M Ramakers, Freek J Beekman, Ekaterina Dadachova, Marnix Geh Lam, H Charles Vogely, Bart Ch van der Wal, Jos Ag van Strijp, Alexander R Horswill, Harrie Weinans, Suzan Hm Rooijakkers
Implant-associated Staphylococcus aureus infections are difficult to treat because of biofilm formation. Bacteria in a biofilm are often insensitive to antibiotics and host immunity. Monoclonal antibodies (mAbs) could provide an alternative approach to improve the diagnosis and potential treatment of biofilm-related infections. Here, we show that mAbs targeting common surface components of S. aureus can recognize clinically relevant biofilm types. The mAbs were also shown to bind a collection of clinical isolates derived from different biofilm-associated infections (endocarditis, prosthetic joint, catheter)...
January 6, 2022: ELife
#9
JOURNAL ARTICLE
Marion W E Frenken, Marion W C Vlemminx, Daisy A A van der Woude, Judith O E H van Laar, S Guid Oei
Electrohysterography monitors the electrical activity of the uterine muscle through electrodes on the maternal abdominal wall. It is a non-invasive method for uterine contraction monitoring and has a strong correlation with the invasive intra-uterine pressure catheter. A prospective validation study showed a significant higher sensitivity of electrohysterography compared to external tocodynamometry for uterine contraction detection (p-value < 0.001). Moreover, the sensitivity of electrohysterography appears to be less affected by maternal obesity compared to external tocodynamometry...
August 5, 2021: Nederlands Tijdschrift Voor Geneeskunde
#10
JOURNAL ARTICLE
Reza Pakdaman Zangabad, Johan G Bosch, Frits Mastik, Robert H S H Beurskens, Vincent A Henneken, Johannes W Weekamp, Antonius F W van der Steen, Gijs van Soest
Intravascular ultrasound (IVUS) is a well-established diagnostic method that provides images of the vessel wall and atherosclerotic plaques. We investigate the potential for phased-array IVUS utilizing Coded Excitation (CE) for improving the penetration depth and image signal-to-noise ratio (SNR). It is realized on a new experimental broadband Capacitive Micromachined Ultrasound Transducer (CMUT) array, operated in collapse mode, with 96 elements placed at the circumference of a catheter tip with 1.2mm diameter...
January 27, 2021: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
#11
JOURNAL ARTICLE
Ties L Janssen, Elmand Hosseinzoi, Dagmar I Vos, Eelco J Veen, Paul G H Mulder, Adrianus M van der Holst, Lijckle van der Laan
BACKGROUND: Rib fractures are common in ageing people after trauma and delirium is a complication often seen in acutely hospitalized elderly patients. For both conditions, elderly have an increased risk for institutionalization, morbidity, and mortality. This study is the first to investigate risk factors of delirium in elderly patients with rib fractures after trauma. METHODS: A retrospective chart review was performed on patients ≥65 years admitted with rib fractures after blunt chest wall trauma to the Amphia hospital Breda, the Netherlands, between July 2013 and June 2018...
June 13, 2019: BMC Emergency Medicine
#12
COMPARATIVE STUDY
Janneke van Grinsven, Sven M van Dijk, Marcel G Dijkgraaf, Marja A Boermeester, Thomas L Bollen, Marco J Bruno, Sandra van Brunschot, Cornelis H Dejong, Casper H van Eijck, Krijn P van Lienden, Djamila Boerma, Peter van Duijvendijk, Muhammed Hadithi, Jan Willem Haveman, René W van der Hulst, Jeroen M Jansen, Daan J Lips, Eric R Manusama, I Quintus Molenaar, Donald L van der Peet, Alexander C Poen, Rutger Quispel, Alexander F Schaapherder, Erik J Schoon, Matthijs P Schwartz, Tom C Seerden, B W Marcel Spanier, Jan Willem Straathof, Niels G Venneman, Wim van de Vrie, Ben J Witteman, Harry van Goor, Paul Fockens, Hjalmar C van Santvoort, Marc G Besselink
BACKGROUND: Infected necrosis complicates 10% of all acute pancreatitis episodes and is associated with 15-20% mortality. The current standard treatment for infected necrotizing pancreatitis is the step-up approach (catheter drainage, followed, if necessary, by minimally invasive necrosectomy). Catheter drainage is preferably postponed until the stage of walled-off necrosis, which usually takes 4 weeks. This delay stems from the time when open necrosectomy was the standard. It is unclear whether such delay is needed for catheter drainage or whether earlier intervention could actually be beneficial in the current step-up approach...
April 25, 2019: Trials
#13
JOURNAL ARTICLE
René van Es, Hans T van den Broek, Mira van der Naald, Leon de Jong, Eliane R Nieuwenhuis, Adriaan O Kraaijeveld, Pieter A Doevendans, Steven A J Chamuleau, Frebus J van Slochteren
Comparison of the targeting accuracy of a new software method for MRI-fluoroscopy guided endomyocardial interventions with a clinically available 3D endocardial electromechanical mapping system. The new CARTBox2 software enables therapy target selection based on infarction transmurality and local myocardial wall thickness deduced from preoperative MRI scans. The selected targets are stored in standard DICOM datasets. Fusion of these datasets with live fluoroscopy enables real-time visualization of MRI defined targets during fluoroscopy guided interventions without the need for external hardware...
January 28, 2019: International Journal of Cardiovascular Imaging
#14
REVIEW
Patricia Van der Niepen, Frank van Tussenbroek, Hannes Devos, Erik Debing, Silvia Di Monaco, Pierre Goffette, Parla Astarci, Alexandre Persu
Fibromuscular dysplasia (FMD) is an idiopathic, segmental, non-atherosclerotic and non-inflammatory disease of the musculature of arterial walls, leading to stenosis of small and medium-sized arteries, mostly involving renal and cervical arteries. As a result of better and more systematic screening, it appears that involvement of the splanchnic vascular bed is more frequent than originally assumed. We review epidemiology, pathogenesis, clinical picture as well as diagnosis and treatment of visceral artery (VA) FMD...
November 2018: European Journal of Clinical Investigation
#15
JOURNAL ARTICLE
Sophinese Iskander-Rizk, Pieter Kruizinga, Antonius F W van der Steen, Gijs van Soest
Catheter-based radiofrequency ablation for atrial fibrillation has long-term success in 60-70% of cases. A better assessment of lesion quality, depth, and continuity could improve the procedure's outcome. We investigate here photoacoustic contrast between ablated and healthy atrial-wall tissue in vitro in wavelengths spanning from 410 nm to 1000 nm. We studied single- and multi-wavelength imaging of ablation lesions and we demonstrate that a two-wavelength technique yields precise detection of lesions, achieving a diagnostic accuracy of 97%...
March 1, 2018: Biomedical Optics Express
#16
JOURNAL ARTICLE
Stephanie Phillips, Jasmina Dedic-Hagan, d'Arcy Ferris Baxter, H Van der Wall, G L Falk
BACKGROUND: Excellent analgesia following oesophagectomy facilitates patient comfort, early extubation, physiotherapy and mobilisation, reduces post-operative complications and should enhance recovery. Thoracic epidural analgesia (TEA), the gold standard analgesic regimen for this procedure, is often associated with systemic hypotension treated with inotropes or fluid. This may compromise enhanced recovery and be complicated by anastomotic ischaemia or tissue oedema. METHODS: We report a novel analgesic regimen to reduce post-operative inotrope usage...
June 2018: World Journal of Surgery
#17
JOURNAL ARTICLE
Diederik E van der Feen, Michel Weij, Annemieke Smit-van Oosten, Lysanne M Jorna, Quint A J Hagdorn, Beatrijs Bartelds, Rolf M F Berger
In this protocol, PAH is induced by combining a 60 mg/kg monocrotalin (MCT) injection with increased pulmonary blood flow through an aorto-caval shunt (MCT+Flow). The shunt is created by inserting an 18-G needle from the abdominal aorta into the adjacent caval vein. Increased pulmonary flow has been demonstrated as an essential trigger for a severe form of PAH with distinct phases of disease progression, characterized by early medial hypertrophy followed by neointimal lesions and the progressive occlusion of the small pulmonary vessels...
February 11, 2017: Journal of Visualized Experiments: JoVE
#18
JOURNAL ARTICLE
Bradley R Pieters, Elzbieta van der Steen-Banasik, Geert A Smits, Marisol De Brabandere, Alberto Bossi, Erik Van Limbergen
The standard treatment for muscle-invasive bladder cancer (MIBC) is a radical cystectomy with pelvic lymph node dissection with or without neoadjuvant chemotherapy. In selected cases a bladder sparing approach is possible, for example a limited surgical excision combined with external beam radiotherapy and brachytherapy. To perform brachytherapy flexible catheters have to be implanted in the bladder wall. The implantation is done either by the open retropubic approach or the endoscopic surgical approach. The largest experience for brachytherapy is with low-dose rate and pulsed-dose rate, although some short-term experience with high-dose rate is also reported...
March 2017: Radiotherapy and Oncology
#19
MULTICENTER STUDY
S J van der Wall, F A Klok, P L den Exter, D Barrios, R Morillo, S C Cannegieter, D Jimenez, M V Huisman
UNLABELLED: Essentials Low-molecular-weight heparin (LMWH) injections for venous thromboembolism (VTE) may be burdensome. Patients with active cancer and confirmed VTE were included to evaluate LMWH continuation. The cumulative incidence of discontinuation was 21% after a median period of 90 days. One out of five patients discontinued LMWH injections because of side effects. SUMMARY: Background Current guidelines recommend low-molecular-weight heparin (LMWH) monotherapy for 3-6 months as the first-line treatment for cancer-associated venous thromboembolism (VTE)...
January 2017: Journal of Thrombosis and Haemostasis: JTH
#20
JOURNAL ARTICLE
Vessel wall perforation mechanism of the excimer laser-assisted non-occlusive anastomosis technique.
Jochem Bremmer, Tristan P C van Doormaal, Bon H Verweij, Albert van der Zwan, Cornelius A F Tulleken, Rudolf Verdaasdonk
The excimer laser assisted non-occlusive anastomosis (ELANA) technique is used to make anastomoses on intracerebral arteries. This end-to-side anastomosis is created without temporary occlusion of the recipient artery using a 308-nm excimer laser with a ring-shaped multi-fiber catheter to punch an opening in the arterial wall. Over 500 patients have received an ELANA bypass. However, the vessel wall perforation mechanism of the laser catheter is not known exactly and not 100 % successful. In this study, we aimed to understand the mechanism of ELANA vessel perforation using specialized imaging techniques to ultimately improve its effectiveness...
August 2016: Lasers in Medical Science
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