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https://www.readbyqxmd.com/read/29652200/bursera-copallifera-extracts-have-cytotoxic-and-migration-inhibitory-effects-in-breast-cancer-cell-lines
#1
Fabiola Domínguez, Paola Maycotte, Adilene Acosta-Casique, Sofía Rodríguez-Rodríguez, Diego A Moreno, Federico Ferreres, Juan Carlos Flores-Alonso, María Guadalupe Delgado-López, Martín Pérez-Santos, Maricruz Anaya-Ruiz
Plants from the Bursera genus are widely distributed in the tropical dry forests of Mexico. In traditional medicine, extracts from different species of Bursera have been used for a wide range of biological activities, including the treatment of cancer-related symptoms. Compounds present in the Bursera genus include lignans, flavonoids, steroids, short-chain aliphatic alkanes, acetates, alcohols, ketones, and terpenoids. In some instances, secondary metabolites of these classes of compounds may induce cytotoxicity, and therefore we sought to investigate the effects of B...
April 1, 2018: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29650162/relation-between-hypericin-content-and-morphometric-leaf-parameters-in-hypericum-spp-a-case-of-cubic-degree-polynomial-function
#2
Katarína Kimáková, Linda Petijová, Katarína Bruňáková, Eva Čellárová
Higher plants often accumulate secondary metabolites in multicellular structures or in secretory reservoirs. Biotechnological production of such compounds by cell cultures lacking proper morphological structures is difficult, therefore possibilities for an efficient increase of their formation by organ cultures are being searched. The genus Hypericum comprises many species that store photoactive and phototoxic naphthodianthrones in the dark nodules on their above-ground parts. To date, the relation between the content of hypericins and their proto-forms accumulated in the nodules, and morphological characters of the plant parts containing these structures has not been sufficiently explained...
June 2018: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/29649297/diversity-of-cultivable-fungal-endophytes-in-paullinia-cupana-mart-ducke-and-bioactivity-of-their-secondary-metabolites
#3
Fábio de Azevedo Silva, Rhavena Graziela Liotti, Ana Paula de Araújo Boleti, Érica de Melo Reis, Marilene Borges Silva Passos, Edson Lucas Dos Santos, Olivia Moreira Sampaio, Ana Helena Januário, Carmen Lucia Bassi Branco, Gilvan Ferreira da Silva, Elisabeth Aparecida Furtado de Mendonça, Marcos Antônio Soares
Paullinia cupana is associated with a diverse community of pathogenic and endophytic microorganisms. We isolated and identified endophytic fungal communities from the roots and seeds of P. cupana genotypes susceptible and tolerant to anthracnose that grow in two sites of the Brazilian Amazonia forest. We assessed the antibacterial, antitumor and genotoxic activity in vitro of compounds isolated from the strains Trichoderma asperellum (1BDA) and Diaporthe phaseolorum (8S). In concert, we identified eight fungal species not previously reported as endophytes; some fungal species capable of inhibiting pathogen growth; and the production of antibiotics and compounds with bacteriostatic activity against Pseudomonas aeruginosa in both susceptible and multiresistant host strains...
2018: PloS One
https://www.readbyqxmd.com/read/29648449/knockout-of-rapc-improves-bacillomycin-d-yield-based-on-de-novo-genome-sequencing-of-bacillus-amyloliquefaciens-fmbj
#4
Jing Sun, Shiquan Qian, Jing Lu, Yanan Liu, Fengxia Lu, Xiaomei Bie, Zhaoxin Lu
Bacillus amyloliquefaciens, a gram-positive and soil-dwelling bacterium, could produce secondary metabolites that suppress plant pathogens. In this study, we provided the whole genome sequence results of B. amyloliquefaciens fmbJ which had one circular chromosome of 4,193,344 bp with 4,249 genes, 87 transfer RNA genes, and 27 rRNA genes. In addition, fmbJ was found to contain several gene clusters of antimicrobial lipopeptides (bacillomycin D, surfactin, and fengycin) and bacillomycin D homologues were further comprehensively identified...
April 12, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29642627/a-review-of-the-interactions-between-wheat-and-wheat-pathogens-zymoseptoria-tritici-fusarium-spp-and-parastagonospora-nodorum
#5
REVIEW
Adrian Duba, Klaudia Goriewa-Duba, Urszula Wachowska
Zymoseptoria tritici is a hemibiotrophic pathogen which causes Septoria leaf blotch in wheat. The pathogenesis of the disease consists of a biotrophic phase and a necrotrophic phase. The pathogen infects the host plant by suppressing its immune response in the first stage of infection. Hemibiotrophic pathogens of the genus Fusarium cause Fusarium head blight, and the necrotrophic Parastagonospora nodorum is responsible for Septoria nodorum blotch in wheat. Cell wall-degrading enzymes in plants promote infections by necrotrophic and hemibiotrophic pathogens, and trichothecenes, secondary fungal metabolites, facilitate infections caused by fungi of the genus Fusarium ...
April 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29629557/structural-basis-for-recognition-of-l-lysine-l-ornithine-and-l-2-4-diamino-butyric-acid-by-lysine-cyclodeaminase
#6
Kyungjin Min, Hye-Jin Yoon, Atsushi Matsuura, Yong Hwan Kim, Hyung Ho Lee
L-pipecolic acid is a non-protein amino acid commonly found in plants, animals, and microorganisms. It is a well-known precursor to numerous microbial secondary metabolites and pharmaceuticals, including anticancer agents, immunosuppressants, and several antibiotics. Lysine cyclodeaminase (LCD) catalyzes β-deamination of L-lysine into L-pipecolic acid using β-nicotinamide adenine dinucleotide as a cofactor. Expression of a human homolog of LCD, μ-crystallin, is elevated in prostate cancer patients. To understand the structural features and catalytic mechanisms of LCD, we determined the crystal structures of Streptomyces pristinaespiralis LCD (SpLCD) in (i) a binary complex with NAD+, (ii) a ternary complex with NAD+ and L-pipecolic acid, (iii) a ternary complex with NAD+ and L-proline, and (iv) a ternary complex with NAD+ and L-2,4-diamino butyric acid...
April 5, 2018: Molecules and Cells
https://www.readbyqxmd.com/read/29628819/exploring-the-potentiality-of-novel-rhizospheric-bacterial-strains-against-the-rice-blast-fungus-magnaporthe-oryzae
#7
Narayanappa Amruta, M K Prasanna Kumar, M E Puneeth, Gowdiperu Sarika, Hemanth Kumar Kandikattu, K Vishwanath, Sonnappa Narayanaswamy
Rice blast caused by Magnaporthe oryzae is a major disease. In the present study, we aimed to identify and evaluate the novel bacterial isolates from rice rhizosphere for biocontrol of M. oryzae pathogen. Sixty bacterial strains from the rice plant's rhizosphere were tested for their biocontrol activity against M. oryzae under in vitro and in vivo . Among them, B. amyloliquefaciens had significant high activity against the pathogen. The least disease severity and highest germination were recorded in seeds treated with B...
April 2018: Plant Pathology Journal
https://www.readbyqxmd.com/read/29626813/elevated-co-2-induces-a-global-metabolic-change-in-basil-ocimum-basilicum-l-and-peppermint-mentha-piperita-l-and-improves-their-biological-activity
#8
Soad Al Jaouni, Ahmed M Saleh, Mohammed A M Wadaan, Wael N Hozzein, Samy Selim, Hamada AbdElgawad
Many studies have discussed the influence of elevated carbon dioxide (eCO2 ) on modeling and crop plants. However, much less effort has been dedicated to herbal plants. In this study, a robust monitoring for the levels of 94 primary and secondary metabolites and minerals in two medicinal herbs, basil (Ocimum basilicum L.) and peppermint (Mentha piperita L.), grwon under both ambient (aCO2 , 360 ppm) and eCO2 (620 ppm) was performed. We also assessed how the changes in herbal tissue chemistry affected their biological activity...
March 29, 2018: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29626640/differential-responses-to-cd-stress-induced-by-exogenous-application-of-cu-zn-or-ca-in-the-medicinal-plant-catharanthus-roseus
#9
Qi Chen, Xueyan Lu, Xiaorui Guo, Yajie Pan, Bofan Yu, Zhonghua Tang, Qingxi Guo
Cd(II) is one of the most widespread and toxic heavy metals and seriously threatens plant growth, furthermore negatively affecting human health. For survival from this metal stress, plants always fight with Cd(II) toxicity by themselves or using other external factors. The effects of second metals copper (Cu(II)), zinc (Zn(II)) and calcium (Ca(II)) on the Cd(II)-affected root morphology, Cd(II) translocation and metabolic responses in Catharanthus roseus were investigated under hydroponic conditions. We found that the Cd-stressed plants displayed the browning and rot root symptom, excess H2 O2 content, lipid peroxidation and Cd(II) accumulation in plants...
April 4, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29626317/mining-and-comparative-survey-of-est-ssr-markers-among-members-of-euphorbiaceae-family
#10
Surojit Sen, Budheswar Dehury, Jagajjit Sahu, Sunayana Rathi, Raj Narain Singh Yadav
Euphorbiaceae represents flowering plants family of tropical and sub-tropical region rich in secondary metabolites of economic importance. To understand and assess the genetic makeup among the members, this study was undertaken to characterize and compare SSR markers from publicly available ESTs and GSSs of nine selected species of the family. Mining of SSRs was performed by MISA, primer designing by Primer3, while functional annotation, gene ontology (GO) and enrichment analysis were performed by Blast2GO...
April 6, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/29625552/low-pyrrolizidine-alkaloid-levels-in-perennial-ryegrass-is-associated-with-the-absence-of-a-homospermidine-synthase-gene
#11
Geoffrey P Gill, Catherine J Bryant, Mikhail Fokin, Jan Huege, Karl Fraser, Chris Jones, Mingshu Cao, Marty J Faville
BACKGROUND: Pyrrolizidine alkaloids (PAs) are a class of secondary metabolites that function as feeding deterrents in a range of different plant species. In perennial ryegrass (Lolium perenne L.) the only PAs that have been identified are the thesinine-rhamnoside group, which displays significant genetic variation. Homospermidine synthase (HSS) has evolved from deoxyhypusine synthase (DHS) and catalyses the first step in the PA pathway, making it a key candidate for the investigation of genes influencing observed PA trait variation...
April 6, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29625111/insect-taste-receptors-relevant-to-host-identification-by-recognition-of-secondary-metabolite-patterns-of-non-host-plants
#12
Mayu Kasubuchi, Fumika Shii, Kana Tsuneto, Takayuki Yamagishi, Satomi Adegawa, Haruka Endo, Ryoichi Sato
The taste sensing system is crucial for food recognition in insects and other animals. It is commonly believed that insect gustatory receptors (Grs) expressed in gustatory organs are indispensable for host plant selection. Many behavioral studies have shown that mono- or oligo-phagous lepidopteran insects use the balance between feeding attractants and feeding deterrents in host plants and that these are sensed by taste organs for host plant recognition. However, the molecular mechanism underlying taste recognition, especially of feeding deterrents, remains to be elucidated...
April 7, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29623715/fatty-acid-composition-of-lipids-of-iris-sibirica
#13
Olga Mykhailenko, Vladimir Kovalyov, Sergey Kovalyov, Erika Toryanik, Tatyana Osolodchenko, Yurii Buidin
Different Iris species are a rich source of secondary metabolites and they are widely used due to their medicinal properties, i.e. such as antibacterial, cytotoxic, hepatoprotective, antiplasmodial, and immunomodulatory effects. Determination of the fatty acid composition is necessary to create complex phytopreparations on their basis, and also, it is important for understanding of the adaptive capabilities of the plant. In our study, a comparative analysis of fatty acids composition of total lipids of the leaves and rhizomes of Iris sibirica was carried out by the gas chromatography-mass spectrometry method...
2018: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/29623517/mini-review-on-photosensitization-by-plants-in-grazing-herbivores
#14
REVIEW
Syeda M Hussain, Valdo Rodrigues Herling, Paulo Henrique Mazza Rodrigues, Ishrat Naz, Hamayun Khan, Muhammad Tahir Khan
Photosensitization is severe dermatitis or oxidative/chemical changes in the epidermal tissues activated by the light-induced excitation of molecules within the tissue. It is a series of reactions mediated through light receptors and is more common when the plant-produced metabolites are heterocyclic/polyphenols in nature. The areas affected are exposed body parts and mostly non-pigmented areas with least ultraviolet protection. Similarly, cellular alteration also occurs in the affected animal's dermal tissues and body parts and grazing animals by the accumulation and activation of photodynamic molecules...
April 6, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29623232/advances-in-the-preclinical-study-of-some-flavonoids-as-potential-antidepressant-agents
#15
REVIEW
León Jesús German-Ponciano, Gilberto Uriel Rosas-Sánchez, Eduardo Rivadeneyra-Domínguez, Juan Francisco Rodríguez-Landa
Flavonoids are phenolic compounds found commonly in plants that protect them against the negative effects of environmental insults. These secondary metabolites have been widely studied in preclinical research because of their biological effects, particularly as antioxidant agents. Diverse flavonoids have been studied to explore their potential therapeutic effects in the treatment of disorders of the central nervous system, including anxiety and depression. The present review discusses advances in the study of some flavonoids as potential antidepressant agents...
2018: Scientifica
https://www.readbyqxmd.com/read/29623182/metabolic-responses-to-drought-stress-in-the-tissues-of-drought-tolerant-and-drought-sensitive-wheat-genotype-seedlings
#16
Rui Guo, LianXuan Shi, Yang Jiao, MingXia Li, XiuLi Zhong, FengXue Gu, Qi Liu, Xu Xia, HaoRu Li
An in-depth understanding of the effects of drought stress on plant metabolism is necessary to improve the drought tolerance of wheat and to utilize genetic resources for the development of drought stress-tolerant wheat varieties. In this study, the profiles of 58 key metabolites produced by wheat seedlings in response to drought stress were investigated to determine various physiological processes related to drought tolerance between drought-tolerant and drought-sensitive wheat genotypes. Results showed that the wheat metabolome was dominated by sugars, organic acids and amino acids; the wheat metabolome played important roles to enhance the drought tolerance of shoots...
April 2018: AoB Plants
https://www.readbyqxmd.com/read/29621655/methodological-aspects-of-biologically-active-compounds-quantification-in-the-genus-hypericum
#17
Sławomir Dresler, Jozef Kováčik, Maciej Strzemski, Ireneusz Sowa, Magdalena Wójciak-Kosior
Accumulation of selected secondary metabolites in two Hypericum species (H. perforatum and H. annulatum) was compared in their vegetative parts (stems and leaves) and in terms of the extraction solvent (80% aq. methanol or 60% aq. ethanol). The presence of chlorogenic acid and quercitrin was not detected in stem of both species. Almost all metabolites were more accumulated in the leaves than in the stems (rutin, hyperoside, quercetin and hypericin) but epicatechin showed the opposite in both species and hyperforin in H...
March 28, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29621148/fungal-metabolite-antagonists-of-plant-pests-and-human-pathogens-structure-activity-relationship-studies
#18
REVIEW
Marco Masi, Paola Nocera, Pierluigi Reveglia, Alessio Cimmino, Antonio Evidente
Fungi are able to produce many bioactive secondary metabolites that belong to different classes of natural compounds. Some of these compounds have been selected for their antagonism against pests and human pathogens and structure-activity relationship (SAR) studies have been performed to better understand which structural features are essential for the biological activity. In some cases, these studies allowed for the obtaining of hemisynthetic derivatives with increased selectivity and stability in respect to the natural products as well as reduced toxicity in view of their potential practical applications...
April 5, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29619432/antibacterial-activity-of-dracontomelon-dao-extracts-on-methicillin-resistant-s-aureus-mrsa-and-e-coli-multiple-drug-resistance-mdr
#19
Yuniati Yuniati, Nurul Hasanah, Sjarif Ismail, Silvia Anitasari, Swandari Paramita
Background: Staphylococcus aureus , methicillin-resistant and Escherichia coli , multidrug-resistant included in the list of antibiotic-resistant priority pathogens from WHO. As multidrug-resistant bacteria problem is increasing, it is necessary to probe new sources for identifying antimicrobial compounds. Medicinal plants represent a rich source of antimicrobial agents. One of the potential plants for further examined as antibacterial is Dracontomelon dao (Blanco) Merr. & Rolfe. The present study designed to find the antibacterial activity of D...
2018: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29617312/metabolomic-profiling-of-the-white-violet-and-red-flowers-of-rhododendron-schlippenbachii-maxim
#20
Chang Ha Park, Hyeon Ji Yeo, Nam Su Kim, Ye Eun Park, Soo-Yun Park, Jae Kwang Kim, Sang Un Park
Rhododendron schlippenbachii Maxim. is a garden plant that is also used for natural medicines as a consequence of the biological activities of its diverse metabolites. We accordingly profiled two anthocyanins and 40 primary and secondary metabolites in the three different colored flowers. The major anthocyanins found in the flowers were cyanidins. The red flowers exhibited the highest accumulation of anthocyanins (1.02 ± 0.02 mg/g dry weight). Principal component analysis was applied to the GC‒TOFMS data...
April 4, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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