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https://www.readbyqxmd.com/read/28429937/total-synthesis-of-two-glycosylated-stilbenes-oxyresveratrol-2-o-%C3%AE-d-glucopyranoside-and-2-3-5-4-tetrahydroxystilbene-2-o-%C3%AE-d-glucopyranoside
#1
Sunil Kumar, Hsueh-Yun Lee, Jing-Ping Liou
Glycosylated stilbenes are biologically active secondary metabolites of plants and have the potential to alleviate a broad range of human diseases. However, some of these compounds are not naturally abundant, and thus the synthesis of such molecules is desirable. This paper reports the first synthesis of oxyresveratrol 2-O-β-d-glucopyranoside (1) and 2,3,5,4'-tetrahydroxystilbene 2-O-β-d-glucopyranoside (1'), which are stilbene glycosides obtained from the rhizomes of Schoenocaulon officinale and Polygonum multiflorum, respectively...
April 21, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28428689/experimental-validation-of-antidiabetic-potential-of-cayratia-trifolia-l-domin-an-indigenous-medicinal-plant
#2
Shahid Iqbal Mohammed, Narendra Subhash Salunkhe, Kishor Sukhlal Vishwakarma, Vijay Laxminarayan Maheshwari
The present study was undertaken to evaluate antidiabetic and antioxidant activities of Cayratia trifolia root extract against streptozotocin induced diabetes in experimental rats to scientifically validate its use against diabetes in some parts of India. Ethanolic extract, showing the highest activity in in vitro experiments, was prepared in saline and administered orally to streptozotocin induced albino Wistar diabetic rats for 21 days. Biochemical parameters liver and muscles glycogen and in vivo antioxidant activity in normal, diabetic control, standard (metformin) and treated animals were determined and compared...
June 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28428141/temporal-impact-of-the-vascular-wilt-pathogen-verticillium-dahliae-on-tomato-root-proteome
#3
Katja Witzel, Anja Buhtz, Rita Grosch
The soil-borne fungus Verticillium dahliae is the causal agent of wilting disease and affects a wide range of plant species worldwide. Here, we report on the time-resolved analysis of the tomato root proteome in response to fungal colonization. Tomato (Solanum lycopersicum cv. Hildares) was inoculated with V. dahliae at the two-leaf stage and roots were harvested at 7, 14 and 21 days post inoculation (dpi). In order to identify proteins related to the fungal spread at the different time points, a subsequent proteome analysis by two-dimensional differential gel electrophoresis (2D-DIGE) was conducted on samples from three independent experiments...
April 17, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28424966/transcriptomic-analysis-of-molecular-responses-in-malus-domestica-m26-roots-affected-by-apple-replant-disease
#4
Stefan Weiß, Melanie Bartsch, Traud Winkelmann
Gene expression studies in roots of apple replant disease affected plants suggested defense reactions towards biotic stress to occur which did not lead to adequate responses to the biotic stressors. Apple replant disease (ARD) leads to growth inhibition and fruit yield reduction in replanted populations and results in economic losses for tree nurseries and fruit producers. The etiology is not well understood on a molecular level and causal agents show a great diversity indicating that no definitive cause, which applies to the majority of cases, has been found out yet...
April 19, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28424705/contemporary-understanding-of-mirna-based-regulation-of-secondary-metabolites-biosynthesis-in-plants
#5
REVIEW
Om P Gupta, Suhas G Karkute, Sagar Banerjee, Nand L Meena, Anil Dahuja
Plant's secondary metabolites such as flavonoids, terpenoids, and alkaloids etc. are known for their role in the defense against various insects-pests of plants and for medicinal benefits in human. Due to the immense biological importance of these phytochemicals, understanding the regulation of their biosynthetic pathway is crucial. In the recent past, advancement in the molecular technologies has enabled us to better understand the proteins, enzymes, genes, etc. involved in the biosynthetic pathway of the secondary metabolites...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28424679/linking-diet-to-colorectal-cancer-the-emerging-role-of-microrna-in-the-communication-between-plant-and-animal-kingdoms
#6
REVIEW
Manuela Del Cornò, Gloria Donninelli, Lucia Conti, Sandra Gessani
Environmental and lifestyle factors, including diet and nutritional habits have been strongly linked to colorectal cancer (CRC). Of note, unhealthy dietary habits leading to adiposity represent a main risk factor for CRC and are associated with a chronic low-grade inflammatory status. Inflammation is a hallmark of almost every type of cancer and can be modulated by several food compounds exhibiting either protective or promoting effects. However, in spite of an extensive research, the underlying mechanisms by which dietary patterns or bioactive food components may influence tumor onset and outcome have not been fully clarified yet...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28422496/the-combined-use-of-proteomics-and-transcriptomics-reveals-a-complex-secondary-metabolite-network-in-peperomia-obtusifolia
#7
Andrea N L Batista, José Roberto A Dos Santos-Pinto, João M Batista, Tatiana M Souza-Moreira, Mariana M Santoni, Cleslei F Zanelli, Massuo J Kato, Silvia N López, Mario S Palma, Maysa Furlan
Peperomia obtusifolia, an ornamental plant from the Piperaceae family, accumulates a series of secondary metabolites with interesting biological properties. From a biosynthesis standpoint, this species produces several benzopyrans derived from orsellinic acid, which is a polyketide typically found in fungi. Additionally, the chiral benzopyrans were reported as racemic and/or as diastereomeric mixtures, which raises questions about the level of enzymatic control in the cyclization step for the formation of the 3,4-dihydro-2H-pyran moiety...
April 19, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28421329/characterization-of-two-tt2-type-myb-transcription-factors-regulating-proanthocyanidin-biosynthesis-in-tetraploid-cotton-gossypium-hirsutum
#8
Nan Lu, Marissa Roldan, Richard A Dixon
Two TT2-type MYB transcription factors identified from tetraploid cotton are involved in regulating proanthocyanidin biosynthesis, providing new strategies for engineering condensed tannins in crops. Proanthocyanidins (PAs), also known as condensed tannins, are important secondary metabolites involved in stress resistance in plants, and are health supplements that help to reduce cholesterol levels. As one of the most widely grown crops in the world, cotton provides the majority of natural fabrics and is a supplemental food for ruminant animals...
April 18, 2017: Planta
https://www.readbyqxmd.com/read/28414068/modulation-of-anthraquinones-and-phloroglucinols-biosynthesis-in-hypericum-spp-by-cryogenic-treatment
#9
Katarína Bruňáková, Eva Čellárová
Beside the high post-cryogenic recovery rate, a reinstated scale of secondary metabolites in recovered plant tissues represents another inevitable aspect of an effective cryopreservation protocol for medicinal plants. The current study was aimed at evaluation of the elicitation potential of cryogenic treatment on secondary metabolism of some Hypericum species. In agreement with our assumption, the cold stimuli applied during the pre-cryogenic phase increased the tolerance to low temperatures (-196°C) in H...
April 13, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28413973/docking-related-survey-on-natural-product-based-new-monoamine-oxidase-inhibitors-and-their-therapeutic-potential
#10
Priyanka Dhiman, Neelam Malik, Anurag Khatkar
This is an exciting period for research on monoamine oxidase and its effects on central nervous system. As the current hitting-one-target therapeutic strategy has become quite inefficient for the treatment of various neurological disorders. The objective of this review is to identify and critically discuss the computational development of multi-target natural and related ligand-MAO protein docking approaches in the study of monoamine oxidase (MAO) enzymes. Computational development of the new compounds form natural and related synthetic origin, active as MAO inhibitors (MAOIs) were discussed in some detail...
April 14, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/28411511/elevated-co2-and-salinity-are-responsible-for-phenolics-enrichment-in-two-differently-pigmented-lettuces
#11
Cristina Sgherri, Usue Pérez-López, Francesco Micaelli, Jon Miranda-Apodaca, Amaia Mena-Petite, Alberto Muñoz-Rueda, Mike Frank Quartacci
Both salt stress and high CO2 level, besides influencing secondary metabolism, can affect oxidative status of plants mainly acting in an opposite way with salinity provoking oxidative stress and elevated CO2 alleviating it. The aim of the present work was to study the changes in the composition of phenolic acids and flavonoids as well as in the antioxidant activity in two differently pigmented lettuce cvs (green or red leaf) when submitted to salinity (200 mM NaCl) or elevated CO2 (700 ppm) or to their combination in order to evaluate how a future global change can affect lettuce quality...
April 7, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28409382/yeast-response-and-tolerance-to-benzoic-acid-involves-the-gcn4-and-stp1-regulated-multidrug-multixenobiotic-resistance-transporter-tpo1
#12
Cláudia P Godinho, Nuno P Mira, Tânia R Cabrito, Miguel C Teixeira, Kaur Alasoo, Joana F Guerreiro, Isabel Sá-Correia
The action of benzoic acid in the food and beverage industries is compromised by the ability of spoilage yeasts to cope with this food preservative. Benzoic acid occurs naturally in many plants and is an intermediate compound in the biosynthesis of many secondary metabolites. The understanding of the mechanisms underlying the response and resistance to benzoic acid stress in the eukaryotic model yeast is thus crucial to design more suitable strategies to deal with this toxic lipophilic weak acid. In this study, the Saccharomyces cerevisiae multidrug transporter Tpo1 was demonstrated to confer resistance to benzoic acid...
April 13, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28409321/an-integrative-overview-of-the-molecular-and-physiological-responses-of-sugarcane-under-drought-conditions
#13
Camilo Elber Vital, Andrea Giordano, Eduardo de Almeida Soares, Thomas Christopher Rhys Williams, Rosilene Oliveira Mesquita, Pedro Marcus Pereira Vidigal, Amanda de Santana Lopes, Túlio Gomes Pacheco, Marcelo Rogalski, Humberto Josué de Oliveira Ramos, Marcelo Ehlers Loureiro
Drought is the main abiotic stress constraining sugarcane production. However, our limited understanding of the molecular mechanisms involved in the drought stress responses of sugarcane impairs the development of new technologies to increase sugarcane drought tolerance. Here, an integrated approach was performed to reveal the molecular and physiological changes in two closely related sugarcane cultivars, including the most extensively planted cultivar in Brazil (cv. RB867515), in response to moderate (-0.5 MPa) and severe (-1 MPa) drought stress at the transcriptional, translational, and posttranslational levels...
April 13, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28409159/nutritional-composition-and-phytochemical-antioxidative-and-antifungal-activities-of-pergularia-tomentosa-l
#14
Imen Lahmar, Hafedh Belghith, Ferjani Ben Abdallah, Karima Belghith
Crude extracts from a medicinal Tunisian plant, Pergularia tomentosa L., were the investigated natural material. Butanolic extract of roots analyzed with IR spectra revealed the presence of hydroxyl, alcoholic, and carboxylic groups and sugars units. Analysis of some secondary metabolites, total phenolic, flavonoids, flavonols, and procyanidins, was performed using different solvents following the increased gradient of polarity. Fruits and leaves contained the highest amounts of all these compounds. Antioxidant properties were evaluated by the determination of free radical scavenging activity and the reducing power of methanolic extracts...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28406728/clinical-evaluation-of-a-polyherbal-nutritional-supplement-in-dyslipidemic-volunteers
#15
Subramanian Suganya, Subapriya Natarajan, Duraipandian Chamundeeswari, Anand Anbarasu, Kunissery A Balasubramanian, Lynn C Schneider, Balaji Nandagopal
Ten important plant parts routinely used in South Indian ethnic food preparation as spices and condiments were investigated for their potential antidyslipidemic properties. The aim of the study was to characterize the biochemical properties of the polyherbal formulation (nutritional supplement) and evaluate its use to control dyslipidemia in patients. Phytochemical evaluation, in vitro α-amylase inhibitory assay, and high performance thin layer chromatography (HPTLC) fingerprinting were carried out with alcoholic extracts of all 10 individual plants and with the nutritional supplement...
April 13, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28403543/responses-of-plant-phenology-growth-defense-and-reproduction-to-interactive-effects-of-warming-and-insect-herbivory
#16
Nathan P Lemoine, Dejeanne Doublet, Juha-Pekka Salminen, Deron E Burkepile, John D Parker
Climate warming can modify plant reproductive fitness through direct and indirect pathways. Direct effects include temperature-driven impacts on growth, reproduction, and secondary metabolites. Indirect effects may manifest through altered species interactions, including herbivory, although studies comparing the interactive effects of warming and herbivory are few. We used experimental warming combined with herbivore exclusion cages to assess the interactive effects of climate warming and herbivory by Popillia japonica, the Japanese beetle, on flowering phenology, growth, defense, and lifetime reproduction of a biennial herb, Oenothera biennis...
April 12, 2017: Ecology
https://www.readbyqxmd.com/read/28403500/nir-spectroscopy-of-actaea-racemosa-l-%C3%A2-rhizome-en-route-to-fast-and-low-cost-quality-assessment
#17
Marian Bittner, Andrea Krähmer, Regina Schenk, Andreas Springer, Gennadi Gudi, Matthias F Melzig
Rhizomes of Actaea racemosa L. (formerly Cimicifuga racemosa) gained increasing interest as a plant-derived drug due to its hormone-like activity and the absence of estrogenic activity. According to the Current Good Manufacturing Practices guidelines and pharmacopeial standards, quality assessment of herbal starting materials includes tests on identity and substitution, as well as quantification of secondary metabolites, usually by HPTLC and LC methods. To reduce the laboratory effort, we investigated near-infrared spectroscopy for rapid species authentication and quantification of metabolites of interest...
April 12, 2017: Planta Medica
https://www.readbyqxmd.com/read/28401460/enhanced-production-of-berberine-in-in-vitro-regenerated-cell-of-tinospora-cordifolia-and-its-analysis-through-lcms-qtof
#18
Jitendra Mittal, Madan Mohan Sharma
Tinospora cordifolia is a prioritized medicinal plant and having an immense medicinal importance especially in Indian medicinal system. But this plant needs a regeneration protocol for its rapid propagation. An efficient regeneration protocol was developed for T. cordifolia using nodal explants. High frequency of multiple shoot formation was induced when the nodal segments were cultured on MS medium supplemented with BAP (1.0 mg L(-1)) and 2-iP (0.5 mg L(-1)). The highest mean number of shoots per nodal explant (7...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28401459/optimizing-culture-conditions-for-establishment-of-hairy-root-culture-of-semecarpus-anacardium-l
#19
Bhuban Mohan Panda, Urmil J Mehta, Sulekha Hazra
Semecarpus anacardium L. is a tree species which produces secondary metabolites of medicinal importance. Roots of the plant have been traditionally used in folk medicines. Different strains of Agrobacterium rhizogenes (A4, ATCC15834 and LBA 9402) were used for induction of hairy roots in in vitro grown tissues of the plant. Hairy root initiation was observed after 25-30 days of infection. Optimum transformation frequency of 61% was achieved on leaf explants with ATCC15834 strain. Infection time of 30 min resulted in greater transformation frequency compared to 10 and 20 min, respectively...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28400780/overexpression-of-a-new-osmotin-like-protein-gene-sindolp-confers-tolerance-against-biotic-and-abiotic-stresses-in-sesame
#20
Supriyo Chowdhury, Arpita Basu, Surekha Kundu
Osmotin-like proteins (OLPs), of PR-5 family, mediate defense against abiotic, and biotic stresses in plants. Overexpression in sesame of an OLP gene (SindOLP), enhanced tolerance against drought, salinity, oxidative stress, and the charcoal rot pathogen. SindOLP was expressed in all parts and localized to the cytosol. The transgenic plants recovered after prolonged drought and salinity stress, showing less electrolyte leakage, more water content, longer roots, and smaller stomatal aperture compared to control plants...
2017: Frontiers in Plant Science
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