keyword
MENU ▼
Read by QxMD icon Read
search

xenobiotic

keyword
https://www.readbyqxmd.com/read/29031220/effects-of-glyphosate-based-herbicide-on-pintado-da-amaz%C3%A3-nia-hematology-histological-aspects-metabolic-parameters-and-genotoxic-potential
#1
Fernando Rafael de Moura, Ritane Rose da Silva Lima, Ana Paula Simões da Cunha, Patrícia da Costa Marisco, Danilo Henrique Aguiar, Marina Mariko Sugui, Adilson Paulo Sinhorin, Valéria Dornelles Gindri Sinhorin
Roundup Original(®) is an herbicide widely used in Mato Grosso's agriculture and it may contamine water bodies, being an unforeseen xenobiotic to aquatic organisms, particularly fish. This study investigated the effects on the hybrid fish jundiara (Leiarius marmoratus×Pseudoplatystoma reticulatum) of an environmentally relevant exposure to this herbicide. Glucose levels in liver, muscle and plasma decreased after exposure to 1.357mgL(-1) of Roundup Original(®) (glyphosate nominal concentration), while glycogen levels reduced in liver and muscle for different times...
September 29, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29027214/development-of-an-alternative-zebrafish-model-for-drug-induced-intestinal-toxicity
#2
Bokyeong Ryu, C-Yoon Kim, Hanseul Oh, Ukjin Kim, Jin Kim, Cho-Rok Jung, Byoung-Hee Lee, Seungki Lee, Seo-Na Chang, Ji Min Lee, Hyung-Min Chung, Jae-Hak Park
An evaluation of intestinal toxicity is important because the mucosal lining of the gastrointestinal tract is the first barrier for oral xenobiotics. Until now, a rat model has been recommended as the standard intestinal toxicity model and the Caco-2 cell line, originated from a human colon adenocarcinoma, has been used as an alternative to this model, but there are limitations regarding cost-effectiveness and the need for mimicry of the human system. In this study, we investigated whether zebrafish could be a valid alternative to rats and Caco-2 cells as an intestinal toxicity model...
October 13, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29025375/dopamine-induced-sult1a3-4-promotes-emt-and-cancer-stemness-in-hepatocellular-carcinoma
#3
Juan Zou, Hong Li, Qianling Huang, Xiaomin Liu, Xiaoxiao Qi, Ying Wang, Linlin Lu, Zhongqiu Liu
Hepatocellular carcinoma has the second highest incidence rate among malignant cancers in China. Hepatocellular carcinoma development is complex because of the metabolism disequilibrium involving SULT1A3/4, a predominant sulfotransferase that metabolizes sulfonic xenobiotics and endogenous catecholamines. However, the correlation between SULT1A3/4 and hepatocellular carcinoma progression is unclear. By utilizing immunofluorescence and immunohistochemical analysis, we found that in nine hepatocellular carcinoma clinical specimens, SULT1A3/4 was abundantly expressed in tumor tissues compared to that in the adjacent tissues...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29023973/ihigh-resolution-mass-spectrometry-of-skin-mucus-for-monitoring-physiological-impacts-and-contaminant-biotransformation-products-in-fathead-minnows-exposed-to-wastewater-effluent
#4
Jonathan D Mosley, Drew R Ekman, Jenna E Cavallin, Daniel L Villeneuve, Gerald T Ankley, Timothy W Collette
High-resolution mass spectrometry is advantageous for monitoring physiological impacts and contaminant biotransformation products in fish exposed to complex wastewater effluent. We evaluated this technique using skin mucus from male and female fathead minnows (Pimephales promelas) exposed to control water or treated wastewater effluent at 5%, 20%, and 100% levels for 21 d, using an onsite, flow-through system providing real-time exposure. Both sex-specific and non-sex-specific responses were observed in the mucus metabolome, the latter suggesting the induction of general compensatory pathways for xenobiotic exposures...
October 11, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29022498/atp-binding-cassette-exporters-structure-and-mechanism-with-a-focus-on-p-glycoprotein-and-mrp1
#5
Maite Rocío Arana, Guillermo Altenberg
The majority of proteins that belong to the ATP-binding cassette (ABC) superfamily are transporters that mediate the efflux of substrates from cells. These exporters include multidrug resistance proteins of the ABCB and ABCC subfamilies, such as P-glycoprotein (Pgp) and MRP1, respectively. These proteins are not only involved in the resistance of cancer to cytotoxic agents, but also in the protection from endo and xenobiotics, and the determination of drug pharmacokinetics, as well as in the pathophysiology of a variety of disorders...
October 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29022000/data-on-efficacy-of-umbelliferone-on-glycoconjugates-and-immunological-marker-in-7-12-dimethylbenz-a-anthracene-induced-oral-carcinogenesis
#6
Annamalai Vijayalakshmi, Ganapathy Sindhu
Umbelliferone, a phenolic coumarin and dietary agent is believed to play a key role in pharmacological activities including anti-cancer and anti-oxidants effect in various in vitro and in vivo models. In present data on the pre-treatment of umbelliferone (30 mg/kg b.w.) for 16 weeks to 7,12-dimethylbenz(a)anthracene induced hamsters provides protection on cellular integrity by observing the status of cell surface glycoconjugates in the circulation and buccal mucosa and cytokeratin immunoexpression in the buccal mucosa of experimental animals...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29020119/human-adipose-derived-stem-cells-support-the-growth-of-limbal-stem-progenitor-cells
#7
Hua Mei, Sheyla González, Martin N Nakatsu, Elfren R Baclagon, Felix V Chen, Sophie X Deng
The most efficient method to expand limbal stem cells (LSCs) in vitro for clinical transplantation is to culture single LSCs directly on growth-arrested mouse fibroblast 3T3 cells. To reduce possible xenobiotic contamination from 3T3s, primary human adipose-derived stem cells (ASCs) were examined as feeder cells to support the expansion of LSCs in vitro. To optimize the ASC-supported culture, freshly isolated limbal epithelial cells in the form of single cells (SC-ASC) or cell clusters (CC-ASC) were cultured using three different methods: LSCs seeded directly on feeder cells, a 3-dimensional (3D) culture system and a 3D culture system with fibrin (fibrin 3D)...
2017: PloS One
https://www.readbyqxmd.com/read/28994638/dendrimers-carotenoids-and-monoclonal-antibodies
#8
Yuriy K Bashmakov, Ivan M Petyaev
Dendrimers are unimolecular architectural nano- or microparticle entities that can accommodate various nutraceuticals and pharmaceuticals between their branches (dendrons) and provide targeted delivery of biomimetics into different tissues upon addition of functionalized groups to the dendrimer's surface. Covalent binding, hydrogen bonds, and electrostatic interactions between dendrimer-composing molecules are known to form and stabilize dendrimer structure. Carotenoids have recently been shown to form dendrimer-like structures and promote targeted delivery of "cargo" molecules into organs characterized by high-carotenoid uptake (adrenal glands, prostate, liver, and brain)...
October 10, 2017: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/28992482/bisphenol-a-in-artificial-soil-effects-on-growth-reproduction-and-immunity-in-earthworms
#9
I Verdú, D Trigo, J L Martínez-Guitarte, M Novo
The application of biosolids in agricultural fields is increasing annually. They contain not only nutrients but also xenobiotics, such as Bisphenol A (BPA). These compounds are not regulated in the use of biosolids in agriculture, which highlights the need to assess their effects on soil life, of which earthworms are most abundant of the animal representatives. In this study the effect of BPA on life-history parameters, such as mortality, growth and reproduction, and on immunity, is evaluated for Dendrobaena veneta and Eisenia fetida...
September 27, 2017: Chemosphere
https://www.readbyqxmd.com/read/28992322/human-cytosolic-sulphotransferase-sult1c3-genomic-analysis-and-functional-characterization-of-splice-variant-sult1c3a-and-sult1c3d
#10
Katsuhisa Kurogi, Takehiko Shimohira, Haruna Kouriki-Nagatomo, Guisheng Zhang, Ethan R Miller, Yoichi Sakakibara, Masahito Suiko, Ming-Cheh Liu
The cytosolic sulphotransferase SULT1C3 remained the most poorly understood human SULT. The SULT1C3 gene has been shown to contain alternative exons 7 and 8, raising the question concerning their evolutionary origin and implying the generation of multiple SULT1C3 variants. Two SULT1C3 splice variants, SULT1C3a and SULT1C3d, were investigated to verify the impact of alternative C-terminal sequences on their sulphating activity. Sequence homology and gene location analyses were performed to verify the orthology of the SULT1C3 gene...
June 29, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28990372/atp-binding-cassette-sub-family-member-2-abcg2-and-xenobiotic-exposure-during-early-mouse-embryonic-stem-cell-differentiation
#11
Mitchell B Rosen, Susan C Jeffay, Harriette P Nichols, Maria R Hoopes, E Sidney Hunter
BACKGROUND: ATP binding cassette sub-family member 2 (ABCG2) is a well-defined efflux transporter found in a variety of tissues. The role of ABCG2 during early embryonic development, however, is not established. Previous work which compared data from the ToxCast screening program with that from in-house studies suggested an association exists between exposure to xenobiotics that regulate Abcg2 transcription and differentiation of mouse embryonic stem cells (mESC), a relationship potentially related to redox homeostasis...
October 9, 2017: Birth defects research
https://www.readbyqxmd.com/read/28987406/ametryn-removal-by-metarhizium-brunneum-biodegradation-pathway-proposal-and-metabolic-background-revealed
#12
Rafał Szewczyk, Anna Kuśmierska, Przemysław Bernat
Ametryn is a representative of a class of s-triazine herbicides absorbed by plant roots and leaves and characterized as a photosynthesis inhibitor. It is still in use in some countries in the farming of pineapples, soybean, corn, cotton, sugar cane or bananas; however, due to the adverse effects of s-triazine herbicides on living organisms use of these pesticides in the European Union has been banned. In the current study, we characterized the biodegradation of ametryn (100 mg L(-1)) by entomopathogenic fungal cosmopolite Metarhizium brunneum...
October 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28987236/associations-of-cord-blood-metabolites-with-perinatal-characteristics-newborn-anthropometry-and-cord-blood-hormones-in-project-viva
#13
Wei Perng, Sheryl L Rifas-Shiman, Scott McCulloch, Leda Chatzi, Christos Mantzoros, Marie-France Hivert, Emily Oken
CONTEXT: Metabolomics has emerged as a powerful tool to characterize biomarkers and elucidate physiological processes underlying adverse health outcomes. Little is known of these relationships during gestation and infancy, which are critical period for development of metabolic disease risk. OBJECTIVES: To identify cord blood metabolite patterns associated with birth size; and to investigate relations of the birth size-associated metabolite patterns, and a branched chain amino acid (BCAA) metabolite pattern with a range of newborn and perinatal characteristics...
November 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28986473/mouse-red-blood-cell-mediated-rare-xenobiotic-phosphorylation-of-a-drug-molecule-not-intended-to-be-a-kinase-substrate
#14
Chungang Gu, Shenghua Wen, Peter Doig, Eric Gangl, Xiaolan Zheng, Yanjun Wang, Jeffrey W Johannes
Phosphorylation of xenobiotics is rare, probably due to a strong evolutionary pressure against it. This rarity may have attracted more attention recently, owing to intentionally designed kinase-substrate analogs which depend on kinase-catalyzed activation to form phosphorylated active drugs. We report a rare phosphorylated metabolite observed unexpectedly in mouse plasma samples after an oral dose of a Tankyrase inhibitor that was not intended to be a kinase substrate, i.e. (S)-2-(4-(6-(3,4-dimethylpiperazin-1-yl)-4-methylpyridin-3-yl)phenyl)-8-(hydroxymethyl)quinazolin-4(3H)-one (AZ2381)...
October 6, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28983453/remote-sensing-between-liver-and-intestine-importance-of-microbial-metabolites
#15
Zidong Donna Fu, Julia Yue Cui
Recent technological advancements including metagenomics sequencing and metabolomics have allowed the discovery of critical functions of gut microbiota in obesity, malnutrition, neurological disorders, asthma, and xenobiotic metabolism. Classification of the human gut microbiome into distinct "enterotypes" has been proposed to serve as a new paradigm for understanding the interplay between microbial variation and human disease phenotypes, as many organs are affected by gut microbiota modifications during the pathogenesis of diseases...
June 2017: Current Pharmacology Reports
https://www.readbyqxmd.com/read/28979245/overview-on-the-biochemical-potential-of-filamentous-fungi-to-degrade-pharmaceutical-compounds
#16
REVIEW
Darío R Olicón-Hernández, Jesús González-López, Elisabet Aranda
Pharmaceuticals represent an immense business with increased demand due to intensive livestock raising and an aging human population, which guarantee the quality of human life and well-being. However, the development of removal technologies for these compounds is not keeping pace with the swift increase in their use. Pharmaceuticals constitute a potential risk group of multiclass chemicals of increasing concern since they are extremely frequent in all environments and have started to exhibit negative effects on micro- and macro-fauna as well as on human health...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28978801/metabolic-alterations-in-multiple-sclerosis-and-the-impact-of-vitamin-d-supplementation
#17
Pavan Bhargava, Kathryn C Fitzgerald, Peter A Calabresi, Ellen M Mowry
BACKGROUND: Our goal was to identify changes in the metabolome in multiple sclerosis (MS) and how vitamin D supplementation alters metabolic profiles in MS patients and healthy controls. METHODS: We applied global untargeted metabolomics to plasma from a cross-sectional cohort of age- and sex-matched MS patients and controls and a second longitudinal cohort of MS patients and healthy controls who received 5,000 IU cholecalciferol daily for 90 days. We applied partial least squares discriminant analysis, weighted correlation network analysis (WGCNA), and pathway analysis to the metabolomics data...
October 5, 2017: JCI Insight
https://www.readbyqxmd.com/read/28976137/effect-of-lupeol-on-antioxidants-and-xenobiotic-enzymes-in-n-butyl-n-4-hydroxybutyl-nitrosamine-induced-bladder-carcinogenesis-in-experimental-rats
#18
Bhoopathy Prabhu, Annamalai Sivakumar, Doraisami Balakrishnan, Sivapatham Sundaresan
Urothelial carcinoma of the bladder is a common malignancy ranked 9(th) with an estimated 356,600 new cases diagnosed annually worldwide. The study showed the protective effects of Lupeol in N-Butyl-N-(4-hydroxybutyl) nitrosamine induced bladder carcinogenesis in in vivo experimental model. Forty male healthy wistar rats were selected randomly divided into four groups. Group I rats served as healthy control. Group II rats were treated with BBN (150 mg/gavage/twice a week) for 8 weeks. Group III rats were treated with BBN + Lupeol [ Lupeol (50 mg/kg bw/day) treatment was started 1 week prior to the BBN treatment, and it was orally administered for 8 weeks]...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28975360/beyond-detoxification-a-role-for-mouse-meh-in-the-hepatic-metabolism-of-endogenous-lipids
#19
Anne Marowsky, Imke Meyer, Kira Erismann-Ebner, Giovanni Pellegrini, Nandkishor Mule, Michael Arand
Microsomal and soluble epoxide hydrolase (mEH and sEH) fulfill apparently distinct roles: Whereas mEH detoxifies xenobiotics, sEH hydrolyzes fatty acid (FA) signaling molecules and is thus implicated in a variety of physiological functions. These epoxy FAs comprise epoxyeicosatrienoic acids (EETs) and epoxy-octadecenoic acids (EpOMEs), which are formed by CYP epoxygenases from arachidonic acid (AA) and linoleic acid, respectively, and then are hydrolyzed to their respective diols, the so-called DHETs and DiHOMEs...
October 3, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28974947/fungal-lactamases-their-occurrence-and-function
#20
REVIEW
Minglu Gao, Anthony E Glenn, Alex A Blacutt, Scott E Gold
Fungi are absorptive feeders and thus must colonize and ramify through their substrate to survive. In so doing they are in competition, particularly in the soil, with myriad microbes. These microbes use xenobiotic compounds as offensive weapons to compete for nutrition, and fungi must be sufficiently resistant to these xenobiotics. One prominent mechanism of xenobiotic resistance is through production of corresponding degrading enzymes. As typical examples, bacterial β-lactamases are well known for their ability to degrade and consequently confer resistance to β-lactam antibiotics, a serious emerging problem in health care...
2017: Frontiers in Microbiology
keyword
keyword
68550
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"