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https://www.readbyqxmd.com/read/27916727/posttraumatic-administration-of-a-sub-anesthestic-dose-of-ketamine-exerts-neuroprotection-via-attenuating-inflammation-and-autophagy
#1
C-Q Wang, Y Ye, F Chen, W-C Han, J-M Sun, X Lu, R Guo, K Cao, M-J Zheng, L-C Liao
As a complex disease, traumatic brain injury (TBI) can result in long-term psychiatric changes and sensorimotor and cognitive impairments. The TBI-induced loss of memory and long-term cognitive dysfunction are related to mechanistic factors including an increased inflammatory response, autophagy, edema, and ischemia. Many published studies have offered evidence for the neuroprotective effects and anti-inflammatory properties of ketamine for TBI patients. Nonetheless, there is a limited understanding of the accurate mechanism that underlies the potential neuroprotective effects of ketamine...
December 1, 2016: Neuroscience
https://www.readbyqxmd.com/read/27829366/anesthestic-management-of-kassabach-meritt-phenomenon-in-an-adult-case-report
#2
Abdelghafour Elkoundi, Mehdi Samali, Noureddine Kartite, Mohammed Tbouda, Mustapha Bensghir, Charki Haimeur
BACKGROUND: Kasabach-Merritt phenomenon (KMP) is characterized by a vascular tumor with profound thrombocytopenia and consumptive coagulopathy that may presents significant challenges for anesthesiologist. CASE PRESENTATION: An 87-year-old man presented with kaposiform hemangioendothelioma involving the right leg in critical condition due to massive bleeding. Hematology investigations indicated the presence of KMP. Association of this type of tumor with KMP in adults has never been reported...
November 9, 2016: BMC Anesthesiology
https://www.readbyqxmd.com/read/27785093/local-anesthesia-for-pain-control-during-transrectal-ultrasound-guided-prostate-biopsy-a-systematic-review-and-meta-analysis
#3
Pu Yan, Xiao-Yan Wang, Wei Huang, Yong Zhang
BACKGROUND: A meta-analysis was performed to evaluate the efficacy and safety of intrarectal local anesthestic (IRLA), periprostatic nerve block (PPNB), and the combined modalities in alleviating the pain during transrectal ultrasound (TRUS)-guided prostate biopsy. MATERIALS AND METHODS: A literature review was performed to identify all published randomized controlled trials (RCTs) about IRLA vs no anesthesia or placebo gel; PPNB vs no injection, periprostatic placebo injection, or IRLA; combined PPNB and IRLA vs PPNB alone; and combined PPNB and intraprostatic nerve block (IPNB) vs PPNB alone before TRUS-guided biopsy...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27607405/a-case-report-of-the-anesthetic-management-for-liver-retransplantation-in-a-patient-with-a-bronchobiliary-fistula
#4
Adrienne Carr, Nelson Gonzalez, Roberto Hernandez-Alejandro, Ramiro Arellano
A 64-year-old woman with a previous liver transplant developed graft failure with biliary complications including a bronchobiliary fistula, which did not respond to preoperative conservative therapy. Liver retransplantation provided definitive therapy for the liver failure and bronchobiliary fistula. We present anesthestic considerations for the intraoperative management of a liver retransplant with one-lung ventilation.
September 7, 2016: A & A Case Reports
https://www.readbyqxmd.com/read/27535492/intraoperative-management-and-early-postoperative-outcomes-of-pediatric-renal-transplants
#5
Katherine Taylor, Wooheon Thomas Kim, Malak Maharramova, Victor Figueroa, Smruthi Ramesh, Armando Lorenzo
INTRODUCTION: Smaller children are presenting for renal transplantation as the treatment of choice for end-stage renal disease. Adult donor organs are more successful than pediatric deceased donor organs. An adult kidney may sequester ~75% of the circulating volume of a 5 year-old child and requires significantly increased cardiac output to maintain renal perfusion. Treatment includes volume, inotropic or vasopressor agents, or central neuroaxial blockade for sympatholysis. We describe the perioperative anesthestic management as a guide to clinical outcomes...
October 2016: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/27479259/-emergence-delirium-in-children-prophylaxis-and-treatment
#6
Julius Z Wermelt, Richard K Ellerkmann
Emergence Delirium in children after general anesthesia is a common and self limitating event. Although it might be seen as being harmless it can cause other serious complications and might leave both parents and other caregivers with a negative impression behind. Although the cause may still not be clear, potential predictors can be named: preschool age, the use of fast acting volatile anesthestics, higher preoperative anxiety levels and postoperative pain.A child-focused approach to reduce preoperative anxiety focusing on distraction methods rather than pharmacological sedation may be the key as well as sufficient postoperative pain control and the use of total intravenous anesthesia...
July 2016: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/27468022/epinephrine-or-gv-26-electrical-stimulation-reduces-inhalant-anesthestic-recovery-time-in-common-snapping-turtles-chelydra-serpentina
#7
RANDOMIZED CONTROLLED TRIAL
Alexandra Goe, Justin Shmalberg, Bonnie Gatson, Pia Bartolini, Jeff Curtiss, James F X Wellehan
Prolonged anesthetic recovery times are a common clinical problem in reptiles following inhalant anesthesia. Diving reptiles have numerous adaptations that allow them to submerge and remain apneic for extended periods. An ability to shunt blood away from pulmonary circulation, possibly due to changes in adrenergic tone, may contribute to their unpredictable inhalant anesthetic recovery times. Therefore, the use of epinephrine could antagonize this response and reduce recovery time. GV-26, an acupuncture point with reported β-adrenergic and respiratory effects, has reduced anesthetic recovery times in other species...
June 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/27017765/-anesthetic-management-of-simultaneous-right-lobectomy-and-esophagectomy-with-a-double-lumen-tracheal-tube-and-bronchial-blocker
#8
Takanobu Fujisawa, Nobuyasu Komasawa, Yu Miyazaki, Yusuke Kusaka, Fumihiro Ohchi, Toshiaki Minami
Anesthestic management with prolonged one-lung ventilation is difficult, especially when the patient continues smoking habit. Here, we report a successful one-lung ventilation and protection with combined use of double-lumen endotracheal tube and bronchial blocker. A 68-year-old man (height 153 cm; weight, 45 kg) was scheduled for simultaneous surgery of right lobectomy and esophagectomy. He kept smoking to the operation day. To protect the ventilated lung, we guided the bronchial lumen of the DLT to the left bronchus under fiberoptic bronchoscope (FOB) guide and inflated the bronchial cuff...
February 2016: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/26736063/significant-effects-of-sex-strain-and-anesthesia-in-the-intrahippocampal-kainate-mouse-model-of-mesial-temporal-lobe-epilepsy
#9
Friederike Twele, Kathrin Töllner, Claudia Brandt, Wolfgang Löscher
The intrahippocampal kainate mouse model of mesial temporal lobe epilepsy is increasingly being used for studies on epileptogenesis and antiepileptogenesis. Almost all previous studies used male mice for this purpose, and no study is available in this or other models of acquired epilepsy that directly compared epileptogenesis in female and male rodents. Epidemiological studies suggest that gender may affect susceptibility to epilepsy and its prognosis; therefore, one goal of this study was to investigate whether sex has an influence on latent period and epileptogenesis in the intrahippocampal kainate model in mice...
February 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/26412993/impact-of-anesthetic-predictors-on-postpartum-hospital-length-of-stay-and-adverse-events-following-cesarean-delivery-a-retrospective-study-in-840-consecutive-parturients
#10
Ting Ting Oh, Colleen G Martel, Allison G Clark, Melissa B Russo, Bobby D Nossaman
BACKGROUND: Cesarean deliveries are increasing, and associated postoperative adverse events are extending hospitalizations. The aims of the present study were to analyze the role of anesthestic predictors during cesarean delivery on the incidences of extended postpartum hospital length of stay (>4 postoperative days) and adverse events. METHODS: The medical records of 840 consecutive patients who underwent cesarean delivery during a 1-year period were abstracted...
2015: Ochsner Journal
https://www.readbyqxmd.com/read/25885247/anesthestic-management-of-a-newborn-for-pedunculated-teratoma-of-oral-cavity
#11
Sandeep Kumar Mishra, J Kavitha, S Kumaravel, K Kumar Lalatendu
No abstract text is available yet for this article.
July 2010: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/25795441/repeated-ketamine-administration-redeems-the-time-lag-for-citalopram-s-antidepressant-like-effects
#12
G-F Zhang, W-X Liu, L-L Qiu, J Guo, X-M Wang, H-L Sun, J-J Yang, Z-Q Zhou
Current available antidepressants exhibit low remission rate with a long response lag time. Growing evidence has demonstrated acute sub-anesthetic dose of ketamine exerts rapid, robust, and lasting antidepressant effects. However, a long term use of ketamine tends to elicit its adverse reactions. The present study aimed to investigate the antidepressant-like effects of intermittent and consecutive administrations of ketamine on chronic unpredictable mild stress (CUMS) rats, and to determine whether ketamine can redeem the time lag for treatment response of classic antidepressants...
June 2015: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/25162644/xenon-impairs-reconsolidation-of-fear-memories-in-a-rat-model-of-post-traumatic-stress-disorder-ptsd
#13
Edward G Meloni, Timothy E Gillis, Jasmine Manoukian, Marc J Kaufman
Xenon (Xe) is a noble gas that has been developed for use in people as an inhalational anesthestic and a diagnostic imaging agent. Xe inhibits glutamatergic N-methyl-D-aspartate (NMDA) receptors involved in learning and memory and can affect synaptic plasticity in the amygdala and hippocampus, two brain areas known to play a role in fear conditioning models of post-traumatic stress disorder (PTSD). Because glutamate receptors also have been shown to play a role in fear memory reconsolidation--a state in which recalled memories become susceptible to modification--we examined whether Xe administered after fear memory reactivation could affect subsequent expression of fear-like behavior (freezing) in rats...
2014: PloS One
https://www.readbyqxmd.com/read/25050821/cocaine-self-administration-and-extinction-alter-medullary-noradrenergic-and-limbic-forebrain-cfos-responses-to-acute-noncontingent-cocaine-injections-in-adult-rats
#14
D M Buffalari, L Rinaman
Central noradrenergic (NA) signaling contributes critically to multiple behavioral effects of cocaine administration, particularly stress- and anxiety-related effects. The present study examined the ability of acute cocaine to induce the immediate early gene product, cFos, in NA neurons and stress-related neural circuits in rats that were cocaine-naïve, or had a history of cocaine self-administration with or without extinction. Rats implanted with jugular catheters were trained to self-administer cocaine (0...
December 5, 2014: Neuroscience
https://www.readbyqxmd.com/read/24434806/brainstem-mechanisms-controlling-cardiovascular-reflexes-in-channel-catfish
#15
J Turesson, M S Hedrick, L Sundin, M L Burleson
Microinjections of kynurenic acid and kainic acid into the general visceral nucleus (nGV), homologous to the mammalian nucleus tractus solitarius of the medulla, in anesthestized, spontaneously breathing catfish were used to identify central areas and mechanisms controlling resting normoxic heart rate and blood pressure and the cardiovascular responses to hypoxia. Kynurenic acid, an antagonist of ionotropic glutamate receptors, significantly reduced resting normoxic heart rate but did not block the bradycardia associated with aquatic hypoxia...
April 2014: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/24415399/how-electroencephalography-serves-the-anesthesiologist
#16
REVIEW
Nicolas Marchant, Robert Sanders, Jamie Sleigh, Audrey Vanhaudenhuyse, Marie-Aurélie Bruno, Jean François Brichant, Steven Laureys, Vincent Bonhomme
Major clinical endpoints of general anesthesia, such as the alteration of consciousness, are achieved through effects of anesthetic agents on the central nervous system, and, more precisely, on the brain. Historically, clinicians and researchers have always been interested in quantifying and characterizing those effects through recordings of surface brain electrical activity, namely electroencephalography (EEG). Over decades of research, the complex signal has been dissected to extract its core substance, with significant advances in the interpretation of the information it may contain...
January 2014: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/24321530/somatostatin-enhances-tooth-pulp-evoked-cervical-dorsal-horn-neuronal-activity-in-the-rat-via-inhibition-of-gabaergic-interneurons
#17
Masayuki Takahashi, Mamoru Takeda, Shigeji Matsumoto
A recent in vitro electrophysiological analysis combined with anatomical approach suggests that a potential disinhibitory mechanism involving somatostatin (SST), which is released by interneurons in the superficial dorsal horn, contributes to nociceptive transmission (Yasaka et al., 2010); however, whether this mechanism occurs in vivo remains to be determined. The aim of the present study was to investigate whether iontophoretic application of SST facilitates the excitability of nociceptive upper cervical spinal dorsal horn (C1) neurons through GABAergic disinhibiton, using extracellular electrophysiological recording with multibarrel electrodes and immunohistochemical techniques...
January 2014: Brain Research Bulletin
https://www.readbyqxmd.com/read/24320612/video-assisted-unilateral-cricoarytenoid-laryngoplasty-in-14-dogs-with-bilateral-idiopathic-laryngeal-paralysis
#18
Laura C Cuddy, J Brad Case, Gary W Ellison, Jennifer L Covey
BACKGROUND: Unilateral cricoarytenoid laryngoplasty is commonly performed for treatment of idiopathic laryngeal paralysis in dogs. Determination of the appropriate tension applied to the suture can be difficult, particularly for the novice surgeon. OBJECTIVE: To describe a technique for video-assisted unilateral cricoarytenoid laryngoplasty (VAUCAL) and to report short-term outcome in dogs undergoing VAUCAL. ANIMALS AND METHODS: Dogs (n = 14) with bilateral idiopathic laryngeal paralysis undergoing VAUCAL between August 2011 and May 2013 were evaluated...
December 2013: Veterinary Quarterly
https://www.readbyqxmd.com/read/23592610/the-protective-effects-of-volatile-anesthestics-against-the-bronchoconstriction-induced-by-an-allergic-reaction-in-sensitized-rabbit-pups
#19
Eniko Lele, Ferenc Petak, Stephanie Carnesecchi, Katalin Virag, Constance Barazzone Argiroffo, Walid Habre
BACKGROUND: Volatile inhaled anesthetics exert a differential protective effect against bronchospasm development after cholinergic stimulation. However, their ability to inhibit the adverse respiratory consequences of an anaphylactic reaction after exposure to an allergen has not been characterized. We therefore compared the abilities of isoflurane, sevoflurane, and desflurane to prevent the lung constriction induced by an allergic reaction in a pediatric model of an anaphylactic reaction...
June 2013: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/23195004/combination-of-epidural-anesthesia-and-general-anesthesia-attenuates-stress-response-to-renal-transplantation-surgery
#20
RANDOMIZED CONTROLLED TRIAL
N Hadimioglu, H Ulugol, H Akbas, N Coskunfirat, Z Ertug, A Dinckan
Choice of the anesthestic technique can reduce or even eliminate stress responses to surgery and decrease the incidence of complications. Our aim was to compare a combination of epidural anesthesia+general anesthesia with general anesthesia alone as regards perioperative insulin resistance and inflammatory activation among renal transplant recipients. Forty-six nondiabetic patients undergoing renal transplantation were prospectively randomized to the epidural anesthesia + general anesthesia group (n = 21), or general anesthesia alone group (n = 25)...
December 2012: Transplantation Proceedings
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